Q3 2023
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| Sell | ENLIVEN THERAPEUTICS INC | $70,498,919 | -40.4% | 5,160,975 | -11.0% | 20.28% | -31.2% | |
| Sell | DISC MEDICINE INC | $20,598,005 | -5.0% | 438,442 | -10.2% | 5.93% | +9.7% | |
| New | DIANTHUS THERAPEUTICS INC | $20,125,849 | – | 1,472,264 | – | 5.79% | – | |
| Sell | MOONLAKE IMMUNOTHERAPEUTICSclass a ord | $17,852,970 | -2.1% | 313,210 | -12.4% | 5.14% | +13.1% | |
| CRNX | Sell | CRINETICS PHARMACEUTICALS IN | $13,748,386 | -11.5% | 462,286 | -46.4% | 3.96% | +2.2% |
| VRDN | Buy | VIRIDIAN THERAPEUTICS INC | $6,289,400 | -5.6% | 410,000 | +46.4% | 1.81% | +9.1% |
| New | TYRA BIOSCIENCES INC | $5,665,667 | – | 411,450 | – | 1.63% | – | |
| GHRS | Buy | GH RESEARCH PLCordinary shares | $4,064,260 | +125.3% | 404,404 | +166.0% | 1.17% | +160.4% |
Q2 2023
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| New | ENLIVEN THERAPEUTICS INC | $118,346,875 | – | 5,798,475 | – | 29.48% | – | |
| New | ENTRADA THERAPEUTICS INC | $66,742,858 | – | 4,408,379 | – | 16.63% | – | |
| New | DISC MEDICINE INC | $21,686,825 | – | 488,442 | – | 5.40% | – | |
| New | RALLYBIO CORP | $20,549,898 | – | 3,630,724 | – | 5.12% | – | |
| VOR | New | VOR BIOPHARMA INC | $19,657,724 | – | 6,361,723 | – | 4.90% | – |
| New | MOONLAKE IMMUNOTHERAPEUTICSclass a ord | $18,231,786 | – | 357,486 | – | 4.54% | – | |
| CRNX | New | CRINETICS PHARMACEUTICALS IN | $15,538,394 | – | 862,286 | – | 3.87% | – |
| ZNTL | New | ZENTALIS PHARMACEUTICALS INC | $13,822,900 | – | 490,000 | – | 3.44% | – |
| SCPH | New | SCPHARMACEUTICALS INC | $12,234,593 | – | 1,200,647 | – | 3.05% | – |
| CLDX | New | CELLDEX THERAPEUTICS INC NEW | $10,527,461 | – | 310,270 | – | 2.62% | – |
| VKTX | New | VIKING THERAPEUTICS INC | $9,482,850 | – | 585,000 | – | 2.36% | – |
| COGT | New | COGENT BIOSCIENCES INC | $9,358,810 | – | 790,440 | – | 2.33% | – |
| PHVS | New | PHARVARIS N V | $8,896,264 | – | 587,600 | – | 2.22% | – |
| ARVN | New | ARVINAS INC | $7,942,400 | – | 320,000 | – | 1.98% | – |
| RNA | New | AVIDITY BIOSCIENCES INC | $7,381,005 | – | 665,555 | – | 1.84% | – |
| ANAB | New | ANAPTYSBIO INC | $7,276,289 | – | 357,733 | – | 1.81% | – |
| MRTX | New | MIRATI THERAPEUTICS INC | $6,955,025 | – | 192,500 | – | 1.73% | – |
| VRDN | New | VIRIDIAN THERAPEUTICS INC | $6,661,200 | – | 280,000 | – | 1.66% | – |
| SPRB | New | SPRUCE BIOSCIENCES INC | $5,082,600 | – | 2,364,000 | – | 1.27% | – |
| MRSN | New | MERSANA THERAPEUTICS INC | $4,293,450 | – | 1,305,000 | – | 1.07% | – |
| FIXX | New | HOMOLOGY MEDICINES INC | $4,014,288 | – | 4,535,919 | – | 1.00% | – |
| IMPL | New | IMPEL PHARMACEUTICALS INC | $3,663,685 | – | 2,884,791 | – | 0.91% | – |
| GHRS | New | GH RESEARCH PLCordinary shares | $1,803,741 | – | 152,022 | – | 0.45% | – |
| CDTX | New | CIDARA THERAPEUTICS INC | $1,281,997 | – | 1,134,511 | – | 0.32% | – |
Q4 2022
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| CDTX | Exit | CIDARA THERAPEUTICS INC | $0 | – | -1,134,511 | – | -0.14% | – |
| GMTX | Exit | GEMINI THERAPEUTICS INC | $0 | – | -524,500 | – | -0.16% | – |
| FVAM | Exit | 5 01 ACQUISITION CORP | $0 | – | -365,126 | – | -0.70% | – |
| PHVS | Exit | PHARVARIS N V | $0 | – | -587,600 | – | -0.86% | – |
| JANX | Exit | JANUX THERAPEUTICS INC | $0 | – | -446,266 | – | -1.16% | – |
| RNA | Exit | AVIDITY BIOSCIENCES INC | $0 | – | -390,555 | – | -1.22% | – |
| FIXX | Exit | HOMOLOGY MEDICINES INC | $0 | – | -4,535,919 | – | -1.40% | – |
| ISEE | Exit | IVERIC BIO INC | $0 | – | -508,847 | – | -1.75% | – |
| VRDN | Exit | VIRIDIAN THERAPEUTICS INC | $0 | – | -484,891 | – | -1.90% | – |
| COGT | Exit | COGENT BIOSCIENCES INC | $0 | – | -790,440 | – | -2.26% | – |
| IMPL | Exit | IMPEL NEUROPHARMA INC | $0 | – | -2,884,791 | – | -2.69% | – |
| CRNX | Exit | CRINETICS PHARMACEUTICALS IN | $0 | – | -862,286 | – | -3.24% | – |
| ARVN | Exit | ARVINAS INC | $0 | – | -400,000 | – | -3.41% | – |
| IDYA | Exit | IDEAYA BIOSCIENCES INC | $0 | – | -1,196,298 | – | -3.42% | – |
| SCPH | Exit | SCPHARMACEUTICALS INC | $0 | – | -3,334,852 | – | -4.17% | – |
| VOR | Exit | VOR BIOPHARMA INC | $0 | – | -6,361,723 | – | -4.85% | – |
| AKUS | Exit | AKOUOS INC | $0 | – | -4,135,784 | – | -5.36% | – |
| Exit | PEAR THERAPEUTICS INC | $0 | – | -16,903,603 | – | -6.61% | – | |
| Exit | RALLYBIO CORP | $0 | – | -3,730,724 | – | -10.34% | – | |
| Exit | ENTRADA THERAPEUTICS INC | $0 | – | -4,408,379 | – | -13.31% | – | |
| Exit | CINCOR PHARMA INC | $0 | – | -4,937,646 | – | -31.05% | – |
Q3 2022
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| Buy | CINCOR PHARMA INC | $162,054,000 | +98.3% | 4,937,646 | +13.8% | 31.05% | +53.6% | |
| Sell | PEAR THERAPEUTICS INC | $34,483,000 | +20.2% | 16,903,603 | -9.3% | 6.61% | -6.9% | |
| SCPH | Sell | SCPHARMACEUTICALS INC | $21,743,000 | +26.7% | 3,334,852 | -6.4% | 4.17% | -1.9% |
| IDYA | Sell | IDEAYA BIOSCIENCES INC | $17,849,000 | -7.5% | 1,196,298 | -14.4% | 3.42% | -28.3% |
| COGT | Sell | COGENT BIOSCIENCES INC | $11,793,000 | +15.8% | 790,440 | -30.0% | 2.26% | -10.4% |
| VRDN | New | VIRIDIAN THERAPEUTICS INC | $9,945,000 | – | 484,891 | – | 1.90% | – |
| ISEE | Sell | IVERIC BIO INC | $9,129,000 | -7.7% | 508,847 | -50.5% | 1.75% | -28.5% |
| GMTX | New | GEMINI THERAPEUTICS INC | $860,000 | – | 524,500 | – | 0.16% | – |
| CABA | Exit | CABALETTA BIO INC | $0 | – | -2,064,263 | – | -0.54% | – |
| RXDX | Exit | PROMETHEUS BIOSCIENCES INC | $0 | – | -182,370 | – | -1.27% | – |
Q2 2022
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| New | CINCOR PHARMA INC | $81,721,000 | – | 4,337,646 | – | 20.22% | – | |
| New | ENTRADA THERAPEUTICS INC | $53,694,000 | – | 4,408,379 | – | 13.28% | – | |
| VOR | New | VOR BIOPHARMA INC | $31,618,000 | – | 6,361,723 | – | 7.82% | – |
| New | PEAR THERAPEUTICS INC | $28,693,000 | – | 18,631,771 | – | 7.10% | – | |
| New | RALLYBIO CORP | $28,167,000 | – | 3,730,724 | – | 6.97% | – | |
| IMPL | New | IMPEL NEUROPHARMA INC | $26,886,000 | – | 2,884,791 | – | 6.65% | – |
| AKUS | New | AKOUOS INC | $19,397,000 | – | 4,135,784 | – | 4.80% | – |
| IDYA | New | IDEAYA BIOSCIENCES INC | $19,293,000 | – | 1,398,066 | – | 4.77% | – |
| SCPH | New | SCPHARMACEUTICALS INC | $17,166,000 | – | 3,561,474 | – | 4.25% | – |
| ARVN | New | ARVINAS INC | $16,836,000 | – | 400,000 | – | 4.17% | – |
| CRNX | New | CRINETICS PHARMACEUTICALS IN | $16,082,000 | – | 862,286 | – | 3.98% | – |
| PHVS | New | PHARVARIS N V | $12,986,000 | – | 587,600 | – | 3.21% | – |
| COGT | New | COGENT BIOSCIENCES INC | $10,185,000 | – | 1,129,200 | – | 2.52% | – |
| ISEE | New | IVERIC BIO INC | $9,888,000 | – | 1,027,874 | – | 2.45% | – |
| FIXX | New | HOMOLOGY MEDICINES INC | $8,936,000 | – | 4,535,919 | – | 2.21% | – |
| RNA | New | AVIDITY BIOSCIENCES INC | $5,675,000 | – | 390,555 | – | 1.40% | – |
| JANX | New | JANUX THERAPEUTICS INC | $5,449,000 | – | 446,266 | – | 1.35% | – |
| RXDX | New | PROMETHEUS BIOSCIENCES INC | $5,148,000 | – | 182,370 | – | 1.27% | – |
| FVAM | New | 5 01 ACQUISITION CORP | $3,615,000 | – | 365,126 | – | 0.89% | – |
| CABA | New | CABALETTA BIO INC | $2,188,000 | – | 2,064,263 | – | 0.54% | – |
| CDTX | New | CIDARA THERAPEUTICS INC | $554,000 | – | 1,134,511 | – | 0.14% | – |
Q4 2021
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| SBTX | Exit | SILVERBACK THERAPEUTICS INC | $0 | – | -169,748 | – | -0.34% | – |
| CDTX | Exit | CIDARA THERAPEUTICS INC | $0 | – | -1,134,511 | – | -0.52% | – |
| FVAM | Exit | 5 01 ACQUISITION CORP | $0 | – | -365,126 | – | -0.73% | – |
| JANX | Exit | JANUX THERAPEUTICS INC | $0 | – | -446,266 | – | -1.96% | – |
| ISEE | Exit | IVERIC BIO INC | $0 | – | -770,000 | – | -2.54% | – |
| RNA | Exit | AVIDITY BIOSCIENCES INC | $0 | – | -555,555 | – | -2.78% | – |
| SCPH | Exit | SCPHARMACEUTICALS INC | $0 | – | -3,831,474 | – | -5.17% | – |
| CRNX | Exit | CRINETICS PHARMACEUTICALS IN | $0 | – | -1,362,286 | – | -5.82% | – |
| CABA | Exit | CABALETTA BIO INC | $0 | – | -2,359,263 | – | -5.82% | – |
| ARVN | Exit | ARVINAS INC | $0 | – | -400,000 | – | -6.68% | – |
| IMPL | Exit | IMPEL NEUROPHARMA INC | $0 | – | -2,884,791 | – | -7.14% | – |
| IDYA | Exit | IDEAYA BIOSCIENCES INC | $0 | – | -1,398,066 | – | -7.24% | – |
| FIXX | Exit | HOMOLOGY MEDICINES INC | $0 | – | -4,535,919 | – | -7.25% | – |
| AKUS | Exit | AKOUOS INC | $0 | – | -4,135,784 | – | -9.75% | – |
| Exit | RALLYBIO CORP | $0 | – | -4,190,724 | – | -14.96% | – | |
| VOR | Exit | VOR BIOPHARMA INC | $0 | – | -6,692,429 | – | -21.31% | – |
Q3 2021
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| New | RALLYBIO CORP | $73,673,000 | – | 4,190,724 | – | 14.96% | – | |
| IDYA | Sell | IDEAYA BIOSCIENCES INC | $35,637,000 | -5.6% | 1,398,066 | -22.2% | 7.24% | -23.8% |
| CABA | Sell | CABALETTA BIO INC | $28,689,000 | +11.8% | 2,359,263 | -20.9% | 5.82% | -9.8% |
| RNA | New | AVIDITY BIOSCIENCES INC | $13,683,000 | – | 555,555 | – | 2.78% | – |
| ISEE | New | IVERIC BIO INC | $12,505,000 | – | 770,000 | – | 2.54% | – |
| CDTX | Sell | CIDARA THERAPEUTICS INC | $2,541,000 | -37.3% | 1,134,511 | -43.5% | 0.52% | -49.4% |
| SBTX | New | SILVERBACK THERAPEUTICS INC | $1,694,000 | – | 169,748 | – | 0.34% | – |
Q2 2021
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| VOR | New | VOR BIOPHARMA INC | $124,814,000 | – | 6,692,429 | – | 31.41% | – |
| AKUS | New | AKOUOS INC | $51,904,000 | – | 4,135,784 | – | 13.06% | – |
| IDYA | New | IDEAYA BIOSCIENCES INC | $37,741,000 | – | 1,798,066 | – | 9.50% | – |
| FIXX | New | HOMOLOGY MEDICINES INC | $32,976,000 | – | 4,535,919 | – | 8.30% | – |
| ARVN | New | ARVINAS INC | $30,800,000 | – | 400,000 | – | 7.75% | – |
| CRNX | New | CRINETICS PHARMACEUTICALS IN | $25,679,000 | – | 1,362,286 | – | 6.46% | – |
| CABA | New | CABALETTA BIO INC | $25,665,000 | – | 2,984,263 | – | 6.46% | – |
| IMPL | New | IMPEL NEUROPHARMA INC | $25,530,000 | – | 2,884,791 | – | 6.42% | – |
| SCPH | New | SCPHARMACEUTICALS INC | $23,410,000 | – | 3,831,474 | – | 5.89% | – |
| JANX | New | JANUX THERAPEUTICS INC | $11,134,000 | – | 446,266 | – | 2.80% | – |
| CDTX | New | CIDARA THERAPEUTICS INC | $4,053,000 | – | 2,006,511 | – | 1.02% | – |
| FVAM | New | 5 01 ACQUISITION CORP | $3,640,000 | – | 365,126 | – | 0.92% | – |
Q4 2020
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| CDTX | Exit | Cidara Therapeutics, Inc. | $0 | – | -2,006,511 | – | -1.50% | – |
| CRNX | Exit | Crinetics Pharmaceuticals, Inc. | $0 | – | -1,362,286 | – | -5.61% | – |
| ARVN | Exit | Arvinas, Inc. | $0 | – | -1,000,000 | – | -6.21% | – |
| SCPH | Exit | scPharmaceuticals Inc. | $0 | – | -3,831,474 | – | -7.51% | – |
| CABA | Exit | Cabaletta Bio, Inc. | $0 | – | -3,669,263 | – | -10.46% | – |
| IDYA | Exit | IDEAYA Biosciences, Inc. | $0 | – | -3,463,066 | – | -11.44% | – |
| APRE | Exit | Aprea Therapeutics, Inc. | $0 | – | -2,212,654 | – | -14.00% | – |
| FIXX | Exit | Homology Medicines, Inc. | $0 | – | -5,535,919 | – | -15.58% | – |
| AKUS | Exit | Akouos Inc. | $0 | – | -4,605,784 | – | -27.70% | – |
Q2 2020
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| AKUS | New | Akouos Inc. | $103,630,000 | – | 4,605,784 | – | 22.70% | – |
| APRE | New | Aprea Therapeutics, Inc. | $85,807,000 | – | 2,212,654 | – | 18.79% | – |
| FIXX | New | Homology Medicines, Inc. | $84,091,000 | – | 5,535,919 | – | 18.42% | – |
| IDYA | New | IDEAYA Biosciences, Inc. | $49,210,000 | – | 3,463,066 | – | 10.78% | – |
| CABA | New | Cabaletta Bio, Inc. | $40,876,000 | – | 3,669,263 | – | 8.95% | – |
| ARVN | New | Arvinas, Inc. | $33,540,000 | – | 1,000,000 | – | 7.34% | – |
| SCPH | New | scPharmaceuticals Inc. | $28,200,000 | – | 3,831,474 | – | 6.18% | – |
| CRNX | New | Crinetics Pharmaceuticals, Inc. | $23,867,000 | – | 1,362,286 | – | 5.23% | – |
| CDTX | New | Cidara Therapeutics, Inc. | $7,404,000 | – | 2,006,511 | – | 1.62% | – |