Q4 2019
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| AXSM | Sell | Axsome Therapeutics Inc | $160,001,000 | +390.6% | 1,547,994 | -3.9% | 31.77% | +57.8% |
| CNST | Buy | Constellation Pharmaceuticals | $118,540,000 | +27403.5% | 2,516,242 | +3674.3% | 23.54% | +8748.5% |
| RLMD | New | Relmada Therapeutics Inc | $29,950,000 | – | 767,938 | – | 5.95% | – |
| ETNB | New | 89Bio Inc | $25,206,000 | – | 958,765 | – | 5.00% | – |
| FTSV | New | Forty Seven Inc | $20,330,000 | – | 516,381 | – | 4.04% | – |
| ITCI | New | Intra-Cellular Therapies Inc | $19,728,000 | – | 575,000 | – | 3.92% | – |
| ISEE | New | Iveric Bio Inc | $14,584,000 | – | 1,699,797 | – | 2.90% | – |
| KALV | Sell | Kalvista Pharmaceuticals | $11,041,000 | +49.2% | 619,905 | -2.8% | 2.19% | -52.0% |
| ADVM | New | Adverum Biotechnologies Inc | $10,901,000 | – | 946,234 | – | 2.16% | – |
| MRNS | Buy | Marinus Pharmaceuticals Inc | $10,835,000 | +179.6% | 5,016,164 | +99.4% | 2.15% | -10.1% |
| MRSN | New | Mersana Therapeutics Inc | $8,947,000 | – | 1,561,389 | – | 1.78% | – |
| MYOV | New | Myovant Sciences Ltd | $7,066,000 | – | 455,255 | – | 1.40% | – |
| NXTC | New | Nextcure Inc | $6,742,000 | – | 119,693 | – | 1.34% | – |
| OBSV | Sell | Obseva SA | $3,095,000 | -68.0% | 810,264 | -30.1% | 0.62% | -89.7% |
| PTGX | Sell | Protagonist Therapeutics Inc | $571,000 | -95.6% | 80,929 | -92.5% | 0.11% | -98.6% |
| BLPH | Sell | Bellerophon Therapeutics | $134,000 | -88.5% | 383,955 | -84.1% | 0.03% | -96.2% |
| PRVL | Exit | Prevail Therapeutics Inc | $0 | – | -4,408 | – | -0.03% | – |
| PTI | Exit | Proteostasis Therapeutics Inc | $0 | – | -221,267 | – | -0.12% | – |
| RDUS | Exit | Radius Health Inc | $0 | – | -23,131 | – | -0.37% | – |
| KNSA | Exit | Kiniksa Pharmaceuticals Ltd | $0 | – | -277,137 | – | -1.46% | – |
| TCDA | Exit | Tricida Inc | $0 | – | -80,348 | – | -1.53% | – |
| BCRX | Exit | BioCryst Pharmaceuticals Inc | $0 | – | -2,708,207 | – | -4.79% | – |
| LJPC | Exit | La Jolla Pharmaceuticals | $0 | – | -1,251,898 | – | -6.80% | – |
| RARX | Exit | Ra Pharmaceuticals | $0 | – | -670,350 | – | -9.79% | – |
Q3 2019
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| TXG | New | 10X Genomics Inc. | $15,120,000 | – | 300,000 | – | 9.33% | – |
| MRNS | Buy | Marinus Pharmaceuticals Inc | $3,875,000 | -25.8% | 2,516,164 | +99.9% | 2.39% | -2.0% |
| TCDA | Sell | Tricida Inc | $2,480,000 | -78.3% | 80,348 | -72.3% | 1.53% | -71.3% |
| KNSA | Sell | Kiniksa Pharmaceuticals Ltd | $2,358,000 | -44.2% | 277,137 | -11.3% | 1.46% | -26.3% |
| RDUS | New | Radius Health Inc | $596,000 | – | 23,131 | – | 0.37% | – |
| PRVL | New | Prevail Therapeutics Inc | $54,000 | – | 4,408 | – | 0.03% | – |
| GEMP | Exit | Gemphire Therapeutics | $0 | – | -798,066 | – | -0.30% | – |
| KDMN | Exit | Kadmon Holdings Inc. | $0 | – | -422,141 | – | -0.41% | – |
| ORTX | Exit | Orchard RX Ltd | $0 | – | -676,252 | – | -4.42% | – |
Q2 2019
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| MIST | New | Milestone Pharmaceuticals Inc | $56,106,000 | – | 2,066,529 | – | 26.20% | – |
| AXSM | New | Axsome Therapeutics Inc | $41,492,000 | – | 1,611,329 | – | 19.37% | – |
| RARX | New | Ra Pharmaceuticals | $20,157,000 | – | 670,350 | – | 9.41% | – |
| KALV | New | Kalvista Pharmaceuticals | $14,129,000 | – | 637,884 | – | 6.60% | – |
| OBSV | New | Obseva SA | $13,117,000 | – | 1,159,789 | – | 6.12% | – |
| PTGX | New | Protagonist Therapeutics Inc | $12,986,000 | – | 1,072,348 | – | 6.06% | – |
| LJPC | New | La Jolla Pharmaceuticals | $11,580,000 | – | 1,251,898 | – | 5.41% | – |
| TCDA | New | Tricida Inc | $11,433,000 | – | 289,746 | – | 5.34% | – |
| BCRX | New | BioCryst Pharmaceuticals Inc | $10,264,000 | – | 2,708,207 | – | 4.79% | – |
| ORTX | New | Orchard RX Ltd | $9,461,000 | – | 676,252 | – | 4.42% | – |
| MRNS | New | Marinus Pharmaceuticals Inc | $5,225,000 | – | 1,258,964 | – | 2.44% | – |
| KNSA | New | Kiniksa Pharmaceuticals Ltd | $4,229,000 | – | 312,320 | – | 1.98% | – |
| BLPH | New | Bellerophon Therapeutics | $1,450,000 | – | 2,417,227 | – | 0.68% | – |
| KDMN | New | Kadmon Holdings Inc. | $870,000 | – | 422,141 | – | 0.41% | – |
| CNST | New | Constellation Pharmaceuticals | $819,000 | – | 66,667 | – | 0.38% | – |
| GEMP | New | Gemphire Therapeutics | $646,000 | – | 798,066 | – | 0.30% | – |
| PTI | New | Proteostasis Therapeutics Inc | $216,000 | – | 221,267 | – | 0.10% | – |
Q4 2018
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| CNST | Exit | Constellation Pharmaceuticals | $0 | – | -66,667 | – | -0.34% | – |
| CCXI | Exit | ChemoCentryx Inc | $0 | – | -39,036 | – | -0.37% | – |
| APLS | Exit | Apellis Pharmaceuticals Inc | $0 | – | -50,290 | – | -0.68% | – |
| GEMP | Exit | Gemphire Therapeutics | $0 | – | -869,538 | – | -1.35% | – |
| BLPH | Exit | Bellerophon Therapeutics | $0 | – | -2,274,370 | – | -1.86% | – |
| MRNS | Exit | Marinus Pharmaceuticals Inc | $0 | – | -672,271 | – | -5.08% | – |
| KDMN | Exit | Kadmon Holdings Inc. | $0 | – | -2,388,572 | – | -6.03% | – |
| KNSA | Exit | Kiniksa Pharmaceuticals Ltd | $0 | – | -327,777 | – | -6.32% | – |
| ECYT | Exit | Endocyte Inc | $0 | – | -600,000 | – | -8.05% | – |
| TCDA | Exit | Tricida Inc | $0 | – | -650,585 | – | -15.02% | – |
| OBSV | Exit | Obseva SA | $0 | – | -1,159,789 | – | -15.80% | – |
| BCRX | Exit | BioCryst Pharmaceuticals Inc | $0 | – | -3,061,091 | – | -17.65% | – |
| KALV | Exit | Kalvista Pharmaceuticals | $0 | – | -1,284,931 | – | -21.47% | – |
Q3 2018
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| KALV | New | Kalvista Pharmaceuticals | $28,410,000 | – | 1,284,931 | – | 21.47% | – |
| BCRX | New | BioCryst Pharmaceuticals Inc | $23,356,000 | – | 3,061,091 | – | 17.65% | – |
| OBSV | New | Obseva SA | $20,911,000 | – | 1,159,789 | – | 15.80% | – |
| TCDA | New | Tricida Inc | $19,875,000 | – | 650,585 | – | 15.02% | – |
| ECYT | New | Endocyte Inc | $10,656,000 | – | 600,000 | – | 8.05% | – |
| KNSA | New | Kiniksa Pharmaceuticals Ltd | $8,358,000 | – | 327,777 | – | 6.32% | – |
| KDMN | New | Kadmon Holdings Inc. | $7,978,000 | – | 2,388,572 | – | 6.03% | – |
| MRNS | New | Marinus Pharmaceuticals Inc | $6,723,000 | – | 672,271 | – | 5.08% | – |
| BLPH | New | Bellerophon Therapeutics | $2,456,000 | – | 2,274,370 | – | 1.86% | – |
| GEMP | New | Gemphire Therapeutics | $1,791,000 | – | 869,538 | – | 1.35% | – |
| APLS | New | Apellis Pharmaceuticals Inc | $894,000 | – | 50,290 | – | 0.68% | – |
| CCXI | New | ChemoCentryx Inc | $493,000 | – | 39,036 | – | 0.37% | – |
| CNST | New | Constellation Pharmaceuticals | $449,000 | – | 66,667 | – | 0.34% | – |