Q3 2023
Value | Shares | ↓ Weighting | ||||||
---|---|---|---|---|---|---|---|---|
OLMA | Buy | Olema Pharmaceuticals, Inc. | $22,942,360 | +449.3% | 1,857,681 | +301.7% | 6.12% | +628.2% |
GERN | Buy | Geron Corporation | $22,710,460 | -23.0% | 10,712,481 | +16.6% | 6.06% | +2.1% |
Sell | Moonlake Immunotherapeutics | $16,768,830 | +11.4% | 294,190 | -0.3% | 4.48% | +47.7% | |
IOVA | Buy | Iovance Biotherapeutics Inc | $14,957,656 | -28.0% | 3,287,397 | +11.4% | 3.99% | -4.5% |
INSM | Sell | Insmed Incorporated | $13,318,315 | +19.2% | 527,458 | -0.4% | 3.56% | +57.9% |
New | STRUCTURE THERAPEUTICS INC | $11,634,970 | – | 230,761 | – | 3.11% | – | |
RLAY | Sell | Relay Therapeutics Inc. | $11,371,439 | -33.2% | 1,352,133 | -0.2% | 3.04% | -11.4% |
CBAY | New | CYMABAY THERAPEUTICS INC | $9,106,581 | – | 610,770 | – | 2.43% | – |
KRTX | Sell | Karuna Therapeutics Inc | $8,997,279 | -22.3% | 53,210 | -0.4% | 2.40% | +3.0% |
FOLD | Buy | Amicus Therapeutics Inc. | $8,708,250 | +34.3% | 716,139 | +38.7% | 2.32% | +78.2% |
Buy | Xeris Biopharma Holdings Inc | $7,417,619 | -28.8% | 3,987,967 | +0.3% | 1.98% | -5.6% | |
AVDL | Buy | Avadel Pharmaceuticals PLC | $6,841,507 | +7.8% | 664,224 | +72.5% | 1.83% | +42.9% |
MDGL | Buy | Madrigal Pharmaceuticals inc | $5,967,048 | -32.0% | 40,859 | +7.5% | 1.59% | -9.9% |
KALV | Sell | Kalvista Pharmaceuticals Inc | $5,565,736 | -18.8% | 577,958 | -24.1% | 1.49% | +7.7% |
MORF | New | MORPHIC HOLDING INC | $4,582,000 | – | 200,000 | – | 1.22% | – |
PHAT | Buy | Phathom Pharmaceuticals inc | $3,601,833 | -10.9% | 347,332 | +23.0% | 0.96% | +18.2% |
VKTX | New | VIKING THERAPEUTICS INC | $3,597,750 | – | 325,000 | – | 0.96% | – |
New | Harpoon Therapeutics, Inc. | $1,288,270 | – | 319,670 | – | 0.34% | – | |
ONCR | Exit | Oncorus, Inc. | $0 | – | -2,377,031 | – | -0.02% | – |
Exit | Ventyx Biosciences Inc | $0 | – | -31,747 | – | -0.21% | – | |
HARP | Exit | Harpoon Therapeutics, Inc. | $0 | – | -3,196,707 | – | -0.46% | – |
EWTX | Exit | Edgewise Therapeutics Inc | $0 | – | -712,798 | – | -1.11% | – |
RETA | Exit | Reata Pharmaceuticals, Inc. | $0 | – | -234,478 | – | -4.81% | – |
KDNY | Exit | Chinook Therapeutics, Inc. | $0 | – | -1,003,406 | – | -7.76% | – |
ISEE | Exit | Iveric Bio Inc | $0 | – | -1,214,662 | – | -9.62% | – |
Q2 2023
Value | Shares | ↓ Weighting | ||||||
---|---|---|---|---|---|---|---|---|
CGEM | New | Cullinan Oncology, Inc. | $82,295,364 | – | 7,648,268 | – | 16.57% | – |
ISEE | New | Iveric Bio Inc | $47,784,803 | – | 1,214,662 | – | 9.62% | – |
KDNY | New | Chinook Therapeutics, Inc. | $38,550,859 | – | 1,003,406 | – | 7.76% | – |
GERN | New | Geron Corporation | $29,504,041 | – | 9,191,290 | – | 5.94% | – |
RETA | New | Reata Pharmaceuticals, Inc. | $23,907,377 | – | 234,478 | – | 4.81% | – |
ITOS | New | iTeos Therapeutics, Inc. | $23,116,285 | – | 1,745,943 | – | 4.66% | – |
NTLA | New | Intellia Therapeutics, Inc. | $22,210,378 | – | 544,639 | – | 4.47% | – |
IOVA | New | Iovance Biotherapeutics Inc | $20,768,831 | – | 2,950,118 | – | 4.18% | – |
RPTX | New | Repare Therapeutics, Inc. | $17,349,602 | – | 1,639,849 | – | 3.49% | – |
RLAY | New | Relay Therapeutics Inc. | $17,010,862 | – | 1,354,368 | – | 3.42% | – |
VERV | New | Verve Therapeutics, Inc | $16,086,375 | – | 857,940 | – | 3.24% | – |
New | Moonlake Immunotherapeutics | $15,050,661 | – | 295,111 | – | 3.03% | – | |
RGNX | New | REGENXBIO Inc. | $13,127,793 | – | 656,718 | – | 2.64% | – |
KRTX | New | Karuna Therapeutics Inc | $11,579,573 | – | 53,399 | – | 2.33% | – |
INSM | New | Insmed Incorporated | $11,177,577 | – | 529,743 | – | 2.25% | – |
New | Xeris Biopharma Holdings Inc | $10,414,497 | – | 3,974,999 | – | 2.10% | – | |
MDGL | New | Madrigal Pharmaceuticals inc | $8,780,541 | – | 38,011 | – | 1.77% | – |
CRNX | New | Crinetics Pharmaceuticals Inc. | $8,632,535 | – | 479,053 | – | 1.74% | – |
TVTX | New | Travere Therapeutics Inc. | $8,491,715 | – | 552,846 | – | 1.71% | – |
RVMD | New | Revolution Medicines, Inc. | $7,313,664 | – | 273,408 | – | 1.47% | – |
HOWL | New | Werewolf Therapeutics, Inc. | $7,283,434 | – | 2,388,011 | – | 1.47% | – |
KALV | New | Kalvista Pharmaceuticals Inc | $6,853,842 | – | 761,538 | – | 1.38% | – |
AXSM | New | Axsome Therapeutics, Inc. | $6,725,090 | – | 93,586 | – | 1.35% | – |
FOLD | New | Amicus Therapeutics Inc. | $6,482,706 | – | 516,139 | – | 1.30% | – |
AVDL | New | Avadel Pharmaceuticals PLCsponsored adr | $6,344,635 | – | 384,990 | – | 1.28% | – |
VRDN | New | Viridian Therapeutics Inc | $6,074,134 | – | 255,323 | – | 1.22% | – |
EWTX | New | Edgewise Therapeutics Inc | $5,524,185 | – | 712,798 | – | 1.11% | – |
ADAP | New | Adaptimmune Therapeutics plc | $4,713,719 | – | 5,095,912 | – | 0.95% | – |
OLMA | New | Olema Pharmaceuticals, Inc. | $4,176,375 | – | 462,500 | – | 0.84% | – |
PHAT | New | Phathom Pharmaceuticals inc | $4,042,994 | – | 282,332 | – | 0.81% | – |
HARP | New | Harpoon Therapeutics, Inc. | $2,269,662 | – | 3,196,707 | – | 0.46% | – |
INZY | New | Inozyme Pharma Inc. | $1,820,950 | – | 326,921 | – | 0.37% | – |
New | Ventyx Biosciences Inc | $1,041,302 | – | 31,747 | – | 0.21% | – | |
ONCR | New | Oncorus, Inc. | $96,270 | – | 2,377,031 | – | 0.02% | – |
Q4 2022
Q3 2022
Value | Shares | ↓ Weighting | ||||||
---|---|---|---|---|---|---|---|---|
INBX | Buy | Inhibrx, Inc | $22,976,000 | +97.8% | 1,279,995 | +25.1% | 5.44% | +68.7% |
VERV | New | Verve Therapeutics, Inc | $21,839,000 | – | 635,792 | – | 5.17% | – |
NTLA | Buy | Intellia Therapeutics, Inc. | $20,952,000 | +35.2% | 374,409 | +25.0% | 4.96% | +15.3% |
GERN | Sell | Geron Corporation | $19,709,000 | +50.7% | 8,422,582 | -0.1% | 4.67% | +28.5% |
ISEE | New | Iveric Bio Inc | $18,837,000 | – | 1,050,000 | – | 4.46% | – |
MRUS | Sell | Merus N.V. | $18,394,000 | -11.6% | 918,310 | -0.1% | 4.36% | -24.7% |
RGNX | New | REGENXBIO Inc. | $16,362,000 | – | 619,083 | – | 3.88% | – |
IOVA | Buy | Iovance Biotherapeutics Inc | $16,286,000 | +22.9% | 1,700,000 | +41.7% | 3.86% | +4.8% |
CYTK | Sell | Cytokinetics Inc. | $9,361,000 | +22.7% | 193,205 | -0.5% | 2.22% | +4.6% |
BCRX | Sell | Biocryst Pharmaceuticals Inc. | $7,631,000 | +12.9% | 605,663 | -5.2% | 1.81% | -3.8% |
CRNX | Sell | Crinetics Pharmaceuticals Inc. | $7,163,000 | +4.7% | 364,710 | -0.5% | 1.70% | -10.7% |
TVTX | Sell | Travere Therapeutics Inc. | $6,812,000 | +1.1% | 276,460 | -0.5% | 1.61% | -13.8% |
HRMY | Sell | Harmony Biosciences Hldgs Inc. | $6,058,000 | -9.7% | 136,780 | -0.5% | 1.44% | -23.0% |
ARQT | Sell | Arcutis Biotherapeutics inc | $4,915,000 | -10.8% | 257,185 | -0.5% | 1.16% | -23.9% |
RETA | Sell | Reata Pharmaceuticals Inc | $4,500,000 | -17.7% | 179,058 | -0.5% | 1.07% | -29.8% |
FOLD | Sell | Amicus Therapeutics Inc. | $4,102,000 | -22.9% | 392,946 | -20.7% | 0.97% | -34.3% |
PRVB | Buy | Provention Bio Inc | $3,332,000 | +40.6% | 740,344 | +25.0% | 0.79% | +19.9% |
EWTX | New | Edgewise Therapeutics, Inc. | $2,992,000 | – | 304,027 | – | 0.71% | – |
MDGL | Sell | Madrigal Pharmaceuticals Inc | $2,908,000 | -9.7% | 44,747 | -0.6% | 0.69% | -23.0% |
MIRM | Sell | Mirum Pharmaceuticals Inc. | $2,045,000 | -63.6% | 97,322 | -66.3% | 0.48% | -69.0% |
INZY | Sell | Inozyme Pharma Inc. | $1,772,000 | -44.1% | 661,144 | -0.6% | 0.42% | -52.3% |
EPIX | Sell | ESSA Pharma, Inc. | $738,000 | -64.6% | 405,700 | -38.6% | 0.18% | -69.7% |
NEO | Exit | Neogenomics Inc. | $0 | – | -135,573 | – | -0.31% | – |
KRTX | Exit | Karuna Therapeutics inc | $0 | – | -20,000 | – | -0.70% | – |
EPZM | Exit | Epizyme, Inc. | $0 | – | -3,425,202 | – | -1.40% | – |
Q2 2022
Value | Shares | ↓ Weighting | ||||||
---|---|---|---|---|---|---|---|---|
CGEM | New | Cullinan Oncology, Inc. | $98,051,000 | – | 7,648,268 | – | 27.24% | – |
ITOS | New | iTeos Therapeutics, Inc. | $35,966,000 | – | 1,745,943 | – | 9.99% | – |
RPTX | New | Repare Therapeutics, Inc. | $22,941,000 | – | 1,639,849 | – | 6.37% | – |
MRUS | New | Merus N.V. | $20,817,000 | – | 919,482 | – | 5.78% | – |
NTLA | New | Intellia Therapeutics, Inc. | $15,497,000 | – | 299,409 | – | 4.30% | – |
IOVA | New | Iovance Biotherapeutics Inc Com | $13,248,000 | – | 1,200,000 | – | 3.68% | – |
GERN | New | Geron Corporation | $13,074,000 | – | 8,434,991 | – | 3.63% | – |
INBX | New | Inhibrx, Inc. | $11,615,000 | – | 1,023,325 | – | 3.23% | – |
TCRR | New | TCR2 Therapeutics, Inc. | $9,776,000 | – | 3,370,982 | – | 2.72% | – |
HOWL | New | Werewolf Therapeutics, Inc. | $9,767,000 | – | 2,388,011 | – | 2.71% | – |
CYTK | New | Cytokinetics Inc. | $7,632,000 | – | 194,246 | – | 2.12% | – |
CRNX | New | Crinetics Pharmaceuticals Inc. | $6,839,000 | – | 366,676 | – | 1.90% | – |
BCRX | New | Biocryst Pharmaceuticals Inc. | $6,762,000 | – | 639,089 | – | 1.88% | – |
TVTX | New | Travere Therapeutics Inc. | $6,735,000 | – | 277,950 | – | 1.87% | – |
YMAB | New | YmAbs Therapeutics, Inc. | $6,713,000 | – | 443,702 | – | 1.86% | – |
HRMY | New | Harmony Biosciences Hldgs Inc. | $6,707,000 | – | 137,517 | – | 1.86% | – |
HARP | New | Harpoon Therapeutics, Inc. | $6,106,000 | – | 3,196,707 | – | 1.70% | – |
MIRM | New | Mirum Pharmaceuticals Inc. | $5,615,000 | – | 288,531 | – | 1.56% | – |
ARQT | New | Arcutis Biotherapeutics inc | $5,509,000 | – | 258,500 | – | 1.53% | – |
RETA | New | Reata Pharmaceuticals inc-a | $5,470,000 | – | 180,000 | – | 1.52% | – |
FOLD | New | Amicus Therapeutics Inc. | $5,323,000 | – | 495,603 | – | 1.48% | – |
EPZM | New | Epizyme, Inc. | $5,035,000 | – | 3,425,202 | – | 1.40% | – |
GTHX | New | G1 Therapeutics, Inc. | $4,233,000 | – | 856,798 | – | 1.18% | – |
VSTM | New | Verastem, Inc. | $3,764,000 | – | 3,244,650 | – | 1.05% | – |
MDGL | New | Madrigal Pharmaceuticals inc | $3,221,000 | – | 45,000 | – | 0.90% | – |
INZY | New | Inozyme Pharma Inc. | $3,172,000 | – | 664,980 | – | 0.88% | – |
ONCR | New | Oncorus, Inc. | $2,995,000 | – | 2,377,031 | – | 0.83% | – |
RVMD | New | Revolution Medicines, Inc. | $2,846,000 | – | 146,041 | – | 0.79% | – |
ADCT | New | ADC Therapeutics, Inc. | $2,658,000 | – | 334,384 | – | 0.74% | – |
KRTX | New | Karuna Therapeutics inc | $2,530,000 | – | 20,000 | – | 0.70% | – |
PRVB | New | Provention Bio Inc | $2,370,000 | – | 592,435 | – | 0.66% | – |
EPIX | New | ESSA Pharma, Inc. | $2,082,000 | – | 660,892 | – | 0.58% | – |
PHAT | New | Phathom Pharmaceuticals inc | $1,632,000 | – | 193,326 | – | 0.45% | – |
NEO | New | Neogenomics Inc. | $1,105,000 | – | 135,573 | – | 0.31% | – |
AVDL | New | Avadel Pharmaceuticals Plcadr | $1,006,000 | – | 412,363 | – | 0.28% | – |
AVRO | New | AVROBIO, Inc. | $596,000 | – | 647,918 | – | 0.17% | – |
BDTX | New | Black Diamond Therapeutics, Inc. | $590,000 | – | 239,888 | – | 0.16% | – |
Q4 2021
Q3 2021
Value | Shares | ↓ Weighting | ||||||
---|---|---|---|---|---|---|---|---|
CGEM | Sell | Cullinan Oncology, Inc. | $172,621,000 | -15.3% | 7,648,268 | -3.4% | 26.78% | -20.0% |
ITOS | Sell | iTeos Therapeutics, Inc. | $56,891,000 | -5.2% | 2,107,092 | -9.9% | 8.82% | -10.4% |
RPTX | Sell | Repare Therapeutics, Inc. | $43,030,000 | -17.7% | 1,639,849 | -2.2% | 6.68% | -22.2% |
Buy | MEI Pharma, Inc. | $34,484,000 | +19.4% | 12,494,118 | +23.2% | 5.35% | +12.7% | |
NTLA | New | Intellia Therapeutics, Inc. | $21,815,000 | – | 162,620 | – | 3.38% | – |
MRUS | Buy | Merus N.V. | $20,723,000 | +40.3% | 941,948 | +34.4% | 3.21% | +32.5% |
EPZM | Buy | Epizyme, Inc. | $20,341,000 | +5.0% | 3,972,830 | +70.4% | 3.16% | -0.9% |
TPTX | Buy | Turning Point Therapeutics, Inc. | $18,026,000 | -14.2% | 271,350 | +0.8% | 2.80% | -19.0% |
YMAB | Buy | YmAbs Therapeutics, Inc. | $12,928,000 | +13.4% | 452,970 | +34.3% | 2.00% | +7.0% |
GTHX | Buy | G1 Therapeutics, Inc. | $11,548,000 | -35.2% | 860,502 | +5.9% | 1.79% | -38.9% |
BCRX | New | Biocryst Pharmaceuticals Inc. | $10,128,000 | – | 704,767 | – | 1.57% | – |
ADCT | Buy | ADC Therapeutics, Inc. | $9,357,000 | +76.2% | 344,519 | +58.0% | 1.45% | +66.4% |
CYTK | New | Cytokinetics Inc. | $8,838,000 | – | 247,291 | – | 1.37% | – |
VSTM | New | Verastem, Inc. | $8,701,000 | – | 2,824,857 | – | 1.35% | – |
GERN | New | Geron Corporation | $7,854,000 | – | 5,732,770 | – | 1.22% | – |
TVTX | New | Travere Therapeutics Inc. | $7,433,000 | – | 306,515 | – | 1.15% | – |
NEO | New | Neogenomics Inc. | $7,212,000 | – | 149,504 | – | 1.12% | – |
CRNX | New | Crinetics Pharmaceuticals Inc. | $6,281,000 | – | 298,392 | – | 0.97% | – |
MIRM | New | Mirum Pharmaceuticals Inc. | $6,146,000 | – | 308,532 | – | 0.95% | – |
HRMY | New | Harmony Biosciences Hldgs Inc. | $5,813,000 | – | 151,650 | – | 0.90% | – |
EPIX | New | ESSA Pharma, Inc. | $5,466,000 | – | 683,287 | – | 0.85% | – |
FOLD | New | Amicus Therapeutics Inc. | $5,220,000 | – | 546,558 | – | 0.81% | – |
AVRO | New | AVROBIO, Inc. | $4,809,000 | – | 861,858 | – | 0.75% | – |
LHDX | New | Lucira Health Inc. | $4,394,000 | – | 578,114 | – | 0.68% | – |
RVMD | New | Revolution Medicines, Inc. | $4,127,000 | – | 150,000 | – | 0.64% | – |
AVDL | New | Avadel Pharmaceuticals Plc | $3,920,000 | – | 400,000 | – | 0.61% | – |
INZY | New | Inozyme Pharma Inc. | $3,717,000 | – | 320,724 | – | 0.58% | – |
AXSM | New | Axsome Therapeutics Inc. | $3,631,000 | – | 110,155 | – | 0.56% | – |
BDTX | New | Black Diamond Therapeutics, Inc. | $2,102,000 | – | 248,506 | – | 0.33% | – |
Q2 2021
Value | Shares | ↓ Weighting | ||||||
---|---|---|---|---|---|---|---|---|
CGEM | New | Cullinan Management, Inc. | $203,783,000 | – | 7,913,887 | – | 33.48% | – |
ITOS | New | iTeos Therapeutics, Inc. | $59,985,000 | – | 2,338,581 | – | 9.85% | – |
TCRR | New | TCR2 Therapeutics, Inc. | $55,318,000 | – | 3,370,982 | – | 9.09% | – |
RPTX | New | Repare Therapeutics, Inc. | $52,260,000 | – | 1,676,087 | – | 8.58% | – |
HARP | New | Harpoon Therapeutics, Inc. | $44,338,000 | – | 3,196,707 | – | 7.28% | – |
HOWL | New | Werewolf Therapeutics, Inc. | $41,647,000 | – | 2,388,011 | – | 6.84% | – |
ONCR | New | Oncorus, Inc. | $32,803,000 | – | 2,377,031 | – | 5.39% | – |
New | MEI Pharma, Inc. | $28,893,000 | – | 10,137,859 | – | 4.75% | – | |
TPTX | New | Turning Point Therapeutics, Inc. | $21,002,000 | – | 269,186 | – | 3.45% | – |
EPZM | New | Epizyme, Inc. | $19,375,000 | – | 2,331,534 | – | 3.18% | – |
GTHX | New | G1 Therapeutics, Inc. | $17,833,000 | – | 812,794 | – | 2.93% | – |
MRUS | New | Merus N.V. | $14,768,000 | – | 700,879 | – | 2.43% | – |
YMAB | New | YmAbs Therapeutics, Inc. | $11,400,000 | – | 337,291 | – | 1.87% | – |
ADCT | New | ADC Therapeutics, Inc. | $5,309,000 | – | 218,027 | – | 0.87% | – |
Q4 2020
Value | Shares | ↓ Weighting | ||||||
---|---|---|---|---|---|---|---|---|
AUTL | Exit | Autolus Therapeutics Limited | $0 | – | -39,740 | – | -0.11% | – |
MRUS | Exit | Merus N.V. | $0 | – | -700,879 | – | -2.03% | – |
YMAB | Exit | YmAbs Therapeutics, Inc. | $0 | – | -337,291 | – | -3.12% | – |
GTHX | Exit | G1 Therapeutics, Inc. | $0 | – | -1,423,794 | – | -3.96% | – |
ADCT | Exit | ADC Therapeutics, Inc. | $0 | – | -539,648 | – | -4.29% | – |
TPTX | Exit | Turning Point Therapeutics, Inc. | $0 | – | -308,686 | – | -6.50% | – |
Exit | MEI Pharma, Inc. | $0 | – | -10,137,859 | – | -7.62% | – | |
EPZM | Exit | Epizyme, Inc. | $0 | – | -2,854,737 | – | -8.20% | – |
ITOS | Exit | iTeos Therapeutics, Inc. | $0 | – | -2,355,557 | – | -14.00% | – |
HARP | Exit | Harpoon Therapeutics, Inc. | $0 | – | -3,898,422 | – | -15.96% | – |
TCRR | Exit | TCR2 Therapeutics, Inc. | $0 | – | -3,370,982 | – | -16.50% | – |
RPTX | Exit | Repare Therapeutics, Inc. | $0 | – | -2,388,337 | – | -17.71% | – |
Q3 2020
Value | Shares | ↓ Weighting | ||||||
---|---|---|---|---|---|---|---|---|
ITOS | New | iTeos Therapeutics, Inc. | $58,112,000 | – | 2,355,557 | – | 14.00% | – |
EPZM | Buy | Epizyme, Inc. | $34,057,000 | -9.0% | 2,854,737 | +22.4% | 8.20% | -17.6% |
Q2 2020
Value | Shares | ↓ Weighting | ||||||
---|---|---|---|---|---|---|---|---|
RPTX | New | Repare Therapeutics, Inc. | $74,086,000 | – | 2,388,337 | – | 19.70% | – |
HARP | New | Harpoon Therapeutics, Inc. | $64,714,000 | – | 3,898,422 | – | 17.21% | – |
TCRR | New | TCR2 Therapeutics, Inc. | $51,778,000 | – | 3,370,982 | – | 13.77% | – |
New | MEI Pharma, Inc. | $41,869,000 | – | 10,137,859 | – | 11.13% | – | |
EPZM | New | Epizyme, Inc. | $37,444,000 | – | 2,331,534 | – | 9.96% | – |
GTHX | New | G1 Therapeutics, Inc. | $34,541,000 | – | 1,423,794 | – | 9.18% | – |
ADCT | New | ADC Therapeutics, Inc. | $25,261,000 | – | 539,648 | – | 6.72% | – |
TPTX | New | Turning Point Therapeutics, Inc. | $19,938,000 | – | 308,686 | – | 5.30% | – |
YMAB | New | YmAbs Therapeutics, Inc. | $14,571,000 | – | 337,291 | – | 3.87% | – |
MRUS | New | Merus N.V. | $11,277,000 | – | 700,879 | – | 3.00% | – |
AUTL | New | Autolus Therapeutics Limited | $637,000 | – | 39,740 | – | 0.17% | – |