Cormorant Asset Management, LP Activity Q4 2013-Q3 2023

Q3 2023

			Value		Shares		↓ Weighting
BBIO	Buy	BRIDGEBIO PHARMA INC	$122,950,916	+71.5%	4,662,530	+11.8%	7.17%	+78.5%
AMAM	Buy	AMBRX BIOPHARMA INCsponsored ads	$114,122,424	-27.9%	9,923,689	+3.2%	6.66%	-24.9%
	Buy	ARCELLX INC	$77,142,000	+22.0%	2,150,000	+7.5%	4.50%	+27.0%
APLS	Buy	APELLIS PHARMACEUTICALS INC	$76,080,000	-36.2%	2,000,000	+52.7%	4.44%	-33.6%
CBAY	Buy	CYMABAY THERAPEUTICS INC	$57,403,500	+38.0%	3,850,000	+1.3%	3.35%	+43.6%
OLMA	Buy	OLEMA PHARMACEUTICALS INC	$55,633,835	+99.9%	4,504,764	+46.2%	3.24%	+108.1%
	Buy	STRUCTURE THERAPEUTICS INCsponsored ads	$53,262,327	+122.3%	1,056,373	+83.3%	3.11%	+131.5%
IMVT	Buy	IMMUNOVANT INC	$47,027,750	+350.7%	1,225,000	+122.7%	2.74%	+369.7%
TARS	Buy	TARSUS PHARMACEUTICALS INC	$46,582,669	+81.4%	2,621,422	+84.4%	2.72%	+88.8%
CABA	Buy	CABALETTA BIO INC	$43,824,833	+52.8%	2,879,424	+29.6%	2.56%	+59.1%
CRNX	New	CRINETICS PHARMACEUTICALS IN	$32,770,625	–	1,101,904	–	1.91%	–
PHVS	Buy	PHARVARIS N V	$28,413,670	+92.8%	1,361,460	+39.8%	1.66%	+100.6%
	New	RAYZEBIO INC	$26,246,239	–	1,182,263	–	1.53%	–
KRTX	Buy	KARUNA THERAPEUTICS INC	$23,672,600	+36.5%	140,000	+75.0%	1.38%	+42.1%
ALPN	New	ALPINE IMMUNE SCIENCES INC	$21,755,000	–	1,900,000	–	1.27%	–
	New	MARINUS PHARMACEUTICALS INC	$21,131,250	–	2,625,000	–	1.23%	–
RYTM	Buy	RHYTHM PHARMACEUTICALS INC	$19,486,250	+97.0%	850,000	+41.7%	1.14%	+105.2%
	Sell	ENLIVEN THERAPEUTICS INC	$16,620,286	-57.9%	1,216,712	-37.2%	0.97%	-56.2%
INSM	New	INSMED INC	$14,518,750	–	575,000	–	0.85%	–
ZNTL	Sell	ZENTALIS PHARMACEUTICALS INC	$14,042,000	-54.5%	700,000	-36.1%	0.82%	-52.7%
AXNX	Sell	AXONICS INC	$14,030,000	-13.7%	250,000	-22.4%	0.82%	-10.2%
RNA	Sell	AVIDITY BIOSCIENCES INC	$11,242,294	-61.2%	1,762,115	-32.5%	0.66%	-59.6%
RCKT	Sell	ROCKET PHARMACEUTICALS INC	$9,220,500	-46.6%	450,000	-48.2%	0.54%	-44.4%
	New	NEUMORA THERAPEUTICS INC.	$1,302,256	–	92,293	–	0.08%	–
	New	HARPOON THERAPEUTICS INC	$217,862	–	54,060	–	0.01%	–
BCEL	Exit	ATRECA INC	$0	–	-319,057	–	-0.02%	–
HARP	Exit	HARPOON THERAPEUTICS INC	$0	–	-540,600	–	-0.02%	–
GRPH	Exit	GRAPHITE BIO INC	$0	–	-199,547	–	-0.03%	–
GLTO	Exit	GALECTO INC	$0	–	-1,020,238	–	-0.14%	–
	Exit	GREENLIGHT BIOSCIENCS HLDS P	$0	–	-9,188,659	–	-0.15%	–
OCUL	Exit	OCULAR THERAPEUTIX INC	$0	–	-645,000	–	-0.19%	–
	Exit	LEAP THERAPEUTICS INC	$0	–	-1,073,046	–	-0.19%	–
APLS	Exit	APELLIS PHARMACEUTICALS INCcall	$0	–	-39,000	–	-0.20%	–
AKRO	Exit	AKERO THERAPEUTICS INC	$0	–	-115,000	–	-0.30%	–
AVIR	Exit	ATEA PHARMACEUTICALS INC	$0	–	-1,547,181	–	-0.32%	–
ARQT	Exit	ARCUTIS BIOTHERAPEUTICS INC	$0	–	-800,000	–	-0.43%	–
	Exit	ASTRIA THERAPEUTICS INC	$0	–	-1,000,000	–	-0.47%	–
MORF	Exit	MORPHIC HLDG INC	$0	–	-150,000	–	-0.48%	–
	Exit	LIANBIOsponsored ads	$0	–	-4,250,000	–	-0.54%	–
ISEE	Exit	IVERIC BIO INCcall	$0	–	-300,000	–	-0.66%	–
BBIO	Exit	BRIDGEBIO PHARMA INCput	$0	–	-810,800	–	-0.78%	–
SRPT	Exit	SAREPTA THERAPEUTICS INC	$0	–	-130,000	–	-0.83%	–
VRDN	Exit	VIRIDIAN THERAPEUTICS INC	$0	–	-850,000	–	-1.13%	–
AXSM	Exit	AXSOME THERAPEUTICS INC	$0	–	-340,000	–	-1.37%	–
ETNB	Exit	89BIO INC	$0	–	-1,350,000	–	-1.43%	–
DSGN	Exit	DESIGN THERAPEUTICS INC	$0	–	-5,150,000	–	-1.82%	–
PTGX	Exit	PROTAGONIST THERAPEUTICS INC	$0	–	-1,500,000	–	-2.32%	–

Q2 2023

			Value		Shares		↓ Weighting
	New	MOONLAKE IMMUNOTHERAPEUTICSclass a ord	$415,247,100	–	8,142,100	–	23.26%	–
AMAM	New	AMBRX BIOPHARMA INCsponsored ads	$158,281,911	–	9,616,155	–	8.87%	–
APLS	New	APELLIS PHARMACEUTICALS INC	$119,341,000	–	1,310,000	–	6.68%	–
BMEA	New	BIOMEA FUSION INC	$78,380,646	–	3,570,872	–	4.39%	–
BBIO	New	BRIDGEBIO PHARMA INC	$71,709,879	–	4,169,179	–	4.02%	–
	New	ARCELLX INC	$63,240,000	–	2,000,000	–	3.54%	–
	New	IMMUNEERING CORP	$42,632,251	–	4,204,364	–	2.39%	–
CBAY	New	CYMABAY THERAPEUTICS INC	$41,610,000	–	3,800,000	–	2.33%	–
PTGX	New	PROTAGONIST THERAPEUTICS INC	$41,430,000	–	1,500,000	–	2.32%	–
	New	ENLIVEN THERAPEUTICS INC	$39,516,475	–	1,936,133	–	2.21%	–
PCVX	New	VAXCYTE INC	$33,210,100	–	665,000	–	1.86%	–
DSGN	New	DESIGN THERAPEUTICS INC	$32,445,000	–	5,150,000	–	1.82%	–
ZNTL	New	ZENTALIS PHARMACEUTICALS INC	$30,889,950	–	1,095,000	–	1.73%	–
	New	ERASCA INC	$29,844,559	–	10,813,246	–	1.67%	–
RNA	New	AVIDITY BIOSCIENCES INC	$28,968,355	–	2,612,115	–	1.62%	–
CABA	New	CABALETTA BIO INC	$28,682,650	–	2,221,739	–	1.61%	–
EYPT	New	EYEPOINT PHARMACEUTICALS INC	$27,840,000	–	3,200,000	–	1.56%	–
OLMA	New	OLEMA PHARMACEUTICALS INC	$27,830,460	–	3,082,000	–	1.56%	–
AVTE	New	AEROVATE THERAPEUTICS INC	$26,783,086	–	1,561,696	–	1.50%	–
TARS	New	TARSUS PHARMACEUTICALS INC	$25,685,096	–	1,421,422	–	1.44%	–
ETNB	New	89BIO INC	$25,582,500	–	1,350,000	–	1.43%	–
AXSM	New	AXSOME THERAPEUTICS INC	$24,432,400	–	340,000	–	1.37%	–
	New	STRUCTURE THERAPEUTICS INCsponsored ads	$23,959,826	–	576,373	–	1.34%	–
EWTX	New	EDGEWISE THERAPEUTICS INC	$22,838,374	–	2,946,887	–	1.28%	–
VRDN	New	VIRIDIAN THERAPEUTICS INC	$20,221,500	–	850,000	–	1.13%	–
KRTX	New	KARUNA THERAPEUTICS INC	$17,348,000	–	80,000	–	0.97%	–
LBPH	New	LONGBOARD PHARMACEUTICALS IN	$17,272,055	–	2,353,141	–	0.97%	–
RCKT	New	ROCKET PHARMACEUTICALS INC	$17,258,089	–	868,550	–	0.97%	–
AXNX	New	AXONICS INC	$16,263,453	–	322,240	–	0.91%	–
SRPT	New	SAREPTA THERAPEUTICS INC	$14,887,600	–	130,000	–	0.83%	–
PHVS	New	PHARVARIS N V	$14,740,516	–	973,614	–	0.83%	–
IDYA	New	IDEAYA BIOSCIENCES INC	$14,100,000	–	600,000	–	0.79%	–
BBIO	New	BRIDGEBIO PHARMA INCput	$13,945,760	–	810,800	–	0.78%	–
COGT	New	COGENT BIOSCIENCES INC	$11,840,000	–	1,000,000	–	0.66%	–
ISEE	New	IVERIC BIO INCcall	$11,802,000	–	300,000	–	0.66%	–
STOK	New	STOKE THERAPEUTICS INC	$11,563,388	–	1,087,807	–	0.65%	–
PRAX	New	PRAXIS PRECISION MEDICINES I	$10,925,000	–	9,500,000	–	0.61%	–
IMVT	New	IMMUNOVANT INC	$10,433,500	–	550,000	–	0.58%	–
	New	DISC MEDICINE INC	$9,990,000	–	225,000	–	0.56%	–
RYTM	New	RHYTHM PHARMACEUTICALS INC	$9,894,000	–	600,000	–	0.55%	–
	New	LIANBIOsponsored ads	$9,690,000	–	4,250,000	–	0.54%	–
MORF	New	MORPHIC HLDG INC	$8,599,500	–	150,000	–	0.48%	–
	New	ASTRIA THERAPEUTICS INC	$8,330,000	–	1,000,000	–	0.47%	–
ARQT	New	ARCUTIS BIOTHERAPEUTICS INC	$7,624,000	–	800,000	–	0.43%	–
GHRS	New	GH RESEARCH PLCordinary shares	$7,036,455	–	593,043	–	0.39%	–
VERV	New	VERVE THERAPEUTICS INC	$6,562,500	–	350,000	–	0.37%	–
RAPT	New	RAPT THERAPEUTICS INC	$6,077,500	–	325,000	–	0.34%	–
	New	VIGIL NEUROSCIENCE INC	$5,797,788	–	616,786	–	0.32%	–
AVIR	New	ATEA PHARMACEUTICALS INC	$5,786,457	–	1,547,181	–	0.32%	–
AKRO	New	AKERO THERAPEUTICS INC	$5,369,350	–	115,000	–	0.30%	–
ALXO	New	ALX ONCOLOGY HLDGS INC	$4,596,713	–	612,079	–	0.26%	–
APLS	New	APELLIS PHARMACEUTICALS INCcall	$3,552,900	–	39,000	–	0.20%	–
BCAB	New	BIOATLA INC	$3,543,345	–	1,181,115	–	0.20%	–
CNTA	New	CENTESSA PHARMACEUTICALS PLCsponsored ads	$3,476,304	–	561,600	–	0.20%	–
	New	LEAP THERAPEUTICS INC	$3,358,634	–	1,073,046	–	0.19%	–
OCUL	New	OCULAR THERAPEUTIX INC	$3,328,200	–	645,000	–	0.19%	–
	New	GREENLIGHT BIOSCIENCS HLDS P	$2,739,139	–	9,188,659	–	0.15%	–
GLTO	New	GALECTO INC	$2,571,000	–	1,020,238	–	0.14%	–
	New	BIOHAVEN LTD	$1,960,555	–	81,963	–	0.11%	–
AUTL	New	AUTOLUS THERAPEUTICS PLCspon ads	$933,357	–	392,167	–	0.05%	–
GRPH	New	GRAPHITE BIO INC	$518,822	–	199,547	–	0.03%	–
HARP	New	HARPOON THERAPEUTICS INC	$383,826	–	540,600	–	0.02%	–
BCEL	New	ATRECA INC	$312,676	–	319,057	–	0.02%	–
	New	ORCHARD THERAPEUTICS PLCspon ads new	$133,709	–	25,664	–	0.01%	–

Q4 2022

			Value		Shares		↓ Weighting
IMV	Exit	IMV INC	$0	–	-234,374	–	-0.01%	–
ORTX	Exit	ORCHARD THERAPEUTICS PLCspon ads	$0	–	-256,649	–	-0.01%	–
BCEL	Exit	ATRECA INC	$0	–	-319,057	–	-0.04%	–
HARP	Exit	HARPOON THERAPEUTICS INC	$0	–	-540,600	–	-0.04%	–
GRPH	Exit	GRAPHITE BIO INC	$0	–	-199,547	–	-0.04%	–
	Exit	GELESIS HLDGS INC	$0	–	-626,107	–	-0.05%	–
CMMB	Exit	CHEMOMAB THERAPEUTICS LTDsponsored ads	$0	–	-288,169	–	-0.05%	–
CABA	Exit	CABALETTA BIO INC	$0	–	-1,154,424	–	-0.05%	–
AUTL	Exit	AUTOLUS THERAPEUTICS PLCspon ads	$0	–	-392,167	–	-0.06%	–
	Exit	PYXIS ONCOLOGY INC	$0	–	-668,855	–	-0.09%	–
XFOR	Exit	X4 PHARMACEUTICALS INC	$0	–	-830,654	–	-0.10%	–
GLTO	Exit	GALECTO INC	$0	–	-1,020,238	–	-0.14%	–
	Exit	ICOSAVAX INC	$0	–	-643,825	–	-0.14%	–
YMAB	Exit	Y-MABS THERAPEUTICS INC	$0	–	-150,000	–	-0.15%	–
ELEV	Exit	ELEVATION ONCOLOGY INC	$0	–	-1,952,032	–	-0.15%	–
TALS	Exit	TALARIS THERAPEUTICS INC	$0	–	-900,649	–	-0.17%	–
AMAM	Exit	AMBRX BIOPHARMA INCsponsored ads	$0	–	-2,336,389	–	-0.18%	–
AKUS	Exit	AKOUOS INC	$0	–	-394,500	–	-0.19%	–
ELDN	Exit	ELEDON PHARMACEUTICALS INC	$0	–	-1,223,500	–	-0.24%	–
KROS	Exit	KEROS THERAPEUTICS INC	$0	–	-100,000	–	-0.26%	–
ASND	Exit	ASCENDIS PHARMA A/Ssponsored adr	$0	–	-50,000	–	-0.36%	–
	Exit	VIGIL NEUROSCIENCE INC	$0	–	-616,786	–	-0.39%	–
OLMA	Exit	OLEMA PHARMACEUTICALS INC	$0	–	-2,082,000	–	-0.40%	–
IDYA	Exit	IDEAYA BIOSCIENCES INC	$0	–	-418,320	–	-0.44%	–
PSTX	Exit	POSEIDA THERAPEUTICS INC	$0	–	-1,850,000	–	-0.46%	–
	Exit	TYRA BIOSCIENCES INC	$0	–	-743,988	–	-0.46%	–
ALXO	Exit	ALX ONCOLOGY HLDGS INC	$0	–	-712,079	–	-0.48%	–
GHRS	Exit	GH RESEARCH PLCordinary shares	$0	–	-593,043	–	-0.48%	–
LBPH	Exit	LONGBOARD PHARMACEUTICALS IN	$0	–	-2,118,283	–	-0.55%	–
CNTA	Exit	CENTESSA PHARMACEUTICALS PLCsponsored ads	$0	–	-1,972,728	–	-0.55%	–
AVIR	Exit	ATEA PHARMACEUTICALS INC	$0	–	-1,547,181	–	-0.62%	–
ISEE	Exit	IVERIC BIO INCput	$0	–	-500,000	–	-0.63%	–
PHVS	Exit	PHARVARIS N V	$0	–	-1,207,500	–	-0.65%	–
LLY	Exit	LILLY ELI & CO	$0	–	-30,000	–	-0.68%	–
	Exit	ASTRIA THERAPEUTICS INC	$0	–	-1,200,000	–	-0.76%	–
RAIN	Exit	RAIN THERAPEUTICS INC	$0	–	-2,326,660	–	-0.79%	–
RCKT	Exit	ROCKET PHARMACEUTICALS INC	$0	–	-868,550	–	-0.97%	–
STOK	Exit	STOKE THERAPEUTICS INC	$0	–	-1,087,807	–	-0.98%	–
CYTK	Exit	CYTOKINETICS INC	$0	–	-296,000	–	-1.00%	–
BBIO	Exit	BRIDGEBIO PHARMA INC	$0	–	-1,469,179	–	-1.02%	–
	Exit	TANGO THERAPEUTICS INC	$0	–	-4,116,949	–	-1.04%	–
VECT	Exit	VECTIVBIO HLDG AG	$0	–	-2,536,617	–	-1.06%	–
PLRX	Exit	PLIANT THERAPEUTICS INC	$0	–	-782,788	–	-1.14%	–
BCAB	Exit	BIOATLA INC	$0	–	-2,181,115	–	-1.17%	–
	Exit	AMYLYX PHARMACEUTICALS INC	$0	–	-610,000	–	-1.20%	–
ARQT	Exit	ARCUTIS BIOTHERAPEUTICS INC	$0	–	-1,000,000	–	-1.34%	–
ACET	Exit	ADICET BIO INC	$0	–	-1,400,000	–	-1.39%	–
VERV	Exit	VERVE THERAPEUTICS INC	$0	–	-600,000	–	-1.44%	–
COGT	Exit	COGENT BIOSCIENCES INC	$0	–	-1,450,000	–	-1.51%	–
SRPT	Exit	SAREPTA THERAPEUTICS INC	$0	–	-200,000	–	-1.54%	–
AXNX	Exit	AXONICS INC	$0	–	-322,240	–	-1.59%	–
	Exit	GREENLIGHT BIOSCIENCS HLDS P	$0	–	-10,261,560	–	-1.66%	–
GLUE	Exit	MONTE ROSA THERAPEUTICS INC	$0	–	-2,993,717	–	-1.71%	–
VRDN	Exit	VIRIDIAN THERAPEUTICS INC	$0	–	-1,310,000	–	-1.88%	–
	Exit	VENTYX BIOSCIENCES INC	$0	–	-780,646	–	-1.90%	–
BHVN	Exit	BIOHAVEN PHARMACTL HLDG CO L	$0	–	-184,894	–	-1.95%	–
EWTX	Exit	EDGEWISE THERAPEUTICS INC	$0	–	-3,051,989	–	-2.10%	–
BMEA	Exit	BIOMEA FUSION INC	$0	–	-3,170,872	–	-2.17%	–
	Exit	IMMUNEERING CORP	$0	–	-2,286,181	–	-2.29%	–
RNA	Exit	AVIDITY BIOSCIENCES INC	$0	–	-2,012,115	–	-2.30%	–
KRTX	Exit	KARUNA THERAPEUTICS INC	$0	–	-150,000	–	-2.36%	–
TARS	Exit	TARSUS PHARMACEUTICALS INC	$0	–	-1,971,422	–	-2.36%	–
GOSS	Exit	GOSSAMER BIO INC	$0	–	-3,198,382	–	-2.68%	–
AVTE	Exit	AEROVATE THERAPEUTICS INC	$0	–	-2,330,691	–	-2.70%	–
RVMD	Exit	REVOLUTION MEDICINES INC	$0	–	-1,995,066	–	-2.75%	–
MRTX	Exit	MIRATI THERAPEUTICS INC	$0	–	-575,000	–	-2.81%	–
ALT	Exit	ALTIMMUNE INC	$0	–	-3,442,863	–	-3.07%	–
	Exit	MOONLAKE IMMUNOTHERAPEUTICSclass a ord	$0	–	-6,065,001	–	-3.29%	–
	Exit	ARCELLX INC	$0	–	-3,049,173	–	-4.00%	–
	Exit	ERASCA INC	$0	–	-10,505,554	–	-5.73%	–
DSGN	Exit	DESIGN THERAPEUTICS INC	$0	–	-5,000,000	–	-5.84%	–
APLS	Exit	APELLIS PHARMACEUTICALS INC	$0	–	-1,478,000	–	-7.06%	–
RXDX	Exit	PROMETHEUS BIOSCIENCES INC	$0	–	-1,979,158	–	-8.16%	–

Q3 2022

			Value		Shares		↓ Weighting
RXDX	Sell	PROMETHEUS BIOSCIENCES INC	$116,790,000	+103.9%	1,979,158	-2.5%	8.16%	+88.5%
APLS	Buy	APELLIS PHARMACEUTICALS INC	$100,947,000	+135.0%	1,478,000	+55.6%	7.06%	+117.2%
DSGN	Sell	DESIGN THERAPEUTICS INC	$83,600,000	+8.6%	5,000,000	-9.1%	5.84%	+0.4%
	Buy	ARCELLX INC	$57,233,000	+107.6%	3,049,173	+99.9%	4.00%	+91.8%
ALT	Buy	ALTIMMUNE INC	$43,965,000	+25.3%	3,442,863	+14.8%	3.07%	+15.8%
MRTX	Buy	MIRATI THERAPEUTICS INC	$40,158,000	+99.4%	575,000	+91.7%	2.81%	+84.3%
AVTE	Buy	AEROVATE THERAPEUTICS INC	$38,643,000	+42.9%	2,330,691	+34.7%	2.70%	+32.1%
GOSS	Buy	GOSSAMER BIO INC	$38,317,000	+2208.3%	3,198,382	+1512.2%	2.68%	+2025.4%
TARS	Buy	TARSUS PHARMACEUTICALS INC	$33,751,000	+23.3%	1,971,422	+5.1%	2.36%	+14.0%
KRTX	Buy	KARUNA THERAPEUTICS INC	$33,740,000	+113.4%	150,000	+20.0%	2.36%	+97.2%
EWTX	Sell	EDGEWISE THERAPEUTICS INC	$30,032,000	-2.0%	3,051,989	-20.7%	2.10%	-9.4%
	Buy	VENTYX BIOSCIENCES INC	$27,252,000	+185.5%	780,646	+0.0%	1.90%	+163.9%
VRDN	Buy	VIRIDIAN THERAPEUTICS INC	$26,868,000	+164.6%	1,310,000	+49.3%	1.88%	+144.5%
	Buy	GREENLIGHT BIOSCIENCS HLDS P	$23,807,000	+56.3%	10,261,560	+47.4%	1.66%	+44.4%
SRPT	New	SAREPTA THERAPEUTICS INC	$22,108,000	–	200,000	–	1.54%	–
COGT	Buy	COGENT BIOSCIENCES INC	$21,634,000	+219.8%	1,450,000	+93.3%	1.51%	+195.3%
VERV	Sell	VERVE THERAPEUTICS INC	$20,610,000	+92.5%	600,000	-14.4%	1.44%	+77.9%
ACET	Sell	ADICET BIO INC	$19,908,000	-24.2%	1,400,000	-22.2%	1.39%	-30.0%
ARQT	New	ARCUTIS BIOTHERAPEUTICS INC	$19,110,000	–	1,000,000	–	1.34%	–
	New	AMYLYX PHARMACEUTICALS INC	$17,172,000	–	610,000	–	1.20%	–
BCAB	Buy	BIOATLA INC	$16,795,000	+189.1%	2,181,115	+7.0%	1.17%	+167.4%
PLRX	Buy	PLIANT THERAPEUTICS INC	$16,352,000	+323.2%	782,788	+62.3%	1.14%	+291.4%
VECT	Sell	VECTIVBIO HLDG AG	$15,220,000	-0.8%	2,536,617	-10.7%	1.06%	-8.3%
	Sell	TANGO THERAPEUTICS INC	$14,903,000	-27.0%	4,116,949	-8.7%	1.04%	-32.5%
CYTK	Sell	CYTOKINETICS INC	$14,341,000	-8.7%	296,000	-26.0%	1.00%	-15.7%
	Buy	ASTRIA THERAPEUTICS INC	$10,848,000	+1105.3%	1,200,000	+300.0%	0.76%	+1014.7%
LLY	New	LILLY ELI & CO	$9,701,000	–	30,000	–	0.68%	–
PHVS	Buy	PHARVARIS N V	$9,262,000	-63.4%	1,207,500	+5.4%	0.65%	-66.2%
ISEE	New	IVERIC BIO INCput	$8,970,000	–	500,000	–	0.63%	–
CNTA	Sell	CENTESSA PHARMACEUTICALS PLCsponsored ads	$7,930,000	-44.4%	1,972,728	-32.6%	0.55%	-48.6%
LBPH	Sell	LONGBOARD PHARMACEUTICALS IN	$7,880,000	+12.2%	2,118,283	-6.8%	0.55%	+3.8%
GHRS	Sell	GH RESEARCH PLCordinary shares	$6,891,000	+13.5%	593,043	-2.5%	0.48%	+5.0%
PSTX	New	POSEIDA THERAPEUTICS INC	$6,531,000	–	1,850,000	–	0.46%	–
IDYA	New	IDEAYA BIOSCIENCES INC	$6,241,000	–	418,320	–	0.44%	–
ELDN	Sell	ELEDON PHARMACEUTICALS INC	$3,377,000	+6.1%	1,223,500	-6.3%	0.24%	-2.1%
AMAM	Sell	AMBRX BIOPHARMA INCsponsored ads	$2,523,000	-61.7%	2,336,389	-6.0%	0.18%	-64.7%
TALS	Sell	TALARIS THERAPEUTICS INC	$2,369,000	-55.3%	900,649	-23.3%	0.17%	-58.6%
ELEV	Sell	ELEVATION ONCOLOGY INC	$2,206,000	-20.5%	1,952,032	-1.6%	0.15%	-26.7%
	Sell	ICOSAVAX INC	$2,034,000	-45.5%	643,825	-1.2%	0.14%	-49.6%
XFOR	Buy	X4 PHARMACEUTICALS INC	$1,420,000	+1320.0%	830,654	+698.9%	0.10%	+1137.5%
	Buy	PYXIS ONCOLOGY INC	$1,318,000	-17.2%	668,855	+0.0%	0.09%	-23.3%
CMMB	Buy	CHEMOMAB THERAPEUTICS LTDsponsored ads	$718,000	-32.6%	288,169	+0.0%	0.05%	-38.3%
	Sell	GELESIS HLDGS INC	$676,000	-30.3%	626,107	-0.0%	0.05%	-35.6%
	Exit	RENOVACOR INC	$0	–	-500,000	–	-0.08%	–
ANAB	Exit	ANAPTYSBIO INC	$0	–	-50,000	–	-0.08%	–
MGTX	Exit	MEIRAGTX HLDGS PLC	$0	–	-150,000	–	-0.09%	–
AKRO	Exit	AKERO THERAPEUTICS INC	$0	–	-403,787	–	-0.29%	–
CLDX	Exit	CELLDEX THERAPEUTICS INC NEW	$0	–	-200,000	–	-0.41%	–
AXSM	Exit	AXSOME THERAPEUTICS INC	$0	–	-205,000	–	-0.59%	–
KZR	Exit	KEZAR LIFE SCIENCES INC	$0	–	-1,200,000	–	-0.75%	–
SWTX	Exit	SPRINGWORKS THERAPEUTICS INC	$0	–	-475,000	–	-0.88%	–
ITCI	Exit	INTRA-CELLULAR THERAPIES INC	$0	–	-275,000	–	-1.19%	–
HZNP	Exit	HORIZON THERAPEUTICS PUB L	$0	–	-267,500	–	-1.61%	–
FMTX	Exit	FORMA THERAPEUTICS HLDGS INC	$0	–	-3,172,204	–	-1.65%	–
XBI	Exit	SPDR SER TRcall	$0	–	-450,000	–	-2.53%	–
CCXI	Exit	CHEMOCENTRYX INC	$0	–	-1,425,000	–	-2.67%	–
TPTX	Exit	TURNING POINT THERAPEUTICS I	$0	–	-2,484,220	–	-14.14%	–

Q2 2022

			Value		Shares		↓ Weighting
TPTX	New	TURNING POINT THERAPEUTICS I	$186,938,000	–	2,484,220	–	14.14%	–
DSGN	New	DESIGN THERAPEUTICS INC	$77,000,000	–	5,500,000	–	5.82%	–
	New	ERASCA INC	$58,516,000	–	10,505,554	–	4.42%	–
RXDX	New	PROMETHEUS BIOSCIENCES INC	$57,283,000	–	2,029,158	–	4.33%	–
APLS	New	APELLIS PHARMACEUTICALS INC	$42,959,000	–	950,000	–	3.25%	–
RVMD	New	REVOLUTION MEDICINES INC	$38,884,000	–	1,995,066	–	2.94%	–
BMEA	New	BIOMEA FUSION INC	$37,987,000	–	3,170,872	–	2.87%	–
CCXI	New	CHEMOCENTRYX INC	$35,312,000	–	1,425,000	–	2.67%	–
ALT	New	ALTIMMUNE INC	$35,100,000	–	3,000,000	–	2.65%	–
XBI	New	SPDR SER TRcall	$33,422,000	–	450,000	–	2.53%	–
	New	MOONLAKE IMMUNOTHERAPEUTICSclass a ord	$30,886,000	–	6,065,001	–	2.34%	–
EWTX	New	EDGEWISE THERAPEUTICS INC	$30,646,000	–	3,850,000	–	2.32%	–
RNA	New	AVIDITY BIOSCIENCES INC	$29,236,000	–	2,012,115	–	2.21%	–
GLUE	New	MONTE ROSA THERAPEUTICS INC	$28,949,000	–	2,993,717	–	2.19%	–
	New	ARCELLX INC	$27,572,000	–	1,525,000	–	2.08%	–
TARS	New	TARSUS PHARMACEUTICALS INC	$27,375,000	–	1,875,000	–	2.07%	–
AVTE	New	AEROVATE THERAPEUTICS INC	$27,051,000	–	1,730,691	–	2.04%	–
BHVN	New	BIOHAVEN PHARMACTL HLDG CO L	$26,941,000	–	184,894	–	2.04%	–
ACET	New	ADICET BIO INC	$26,280,000	–	1,800,000	–	1.99%	–
PHVS	New	PHARVARIS N V	$25,326,000	–	1,145,953	–	1.92%	–
FMTX	New	FORMA THERAPEUTICS HLDGS INC	$21,856,000	–	3,172,204	–	1.65%	–
HZNP	New	HORIZON THERAPEUTICS PUB L	$21,336,000	–	267,500	–	1.61%	–
	New	TANGO THERAPEUTICS INC	$20,421,000	–	4,507,843	–	1.54%	–
MRTX	New	MIRATI THERAPEUTICS INC	$20,139,000	–	300,000	–	1.52%	–
AXNX	New	AXONICS INC	$18,261,000	–	322,240	–	1.38%	–
KRTX	New	KARUNA THERAPEUTICS INC	$15,814,000	–	125,000	–	1.20%	–
CYTK	New	CYTOKINETICS INC	$15,716,000	–	400,000	–	1.19%	–
ITCI	New	INTRA-CELLULAR THERAPIES INC	$15,697,000	–	275,000	–	1.19%	–
VECT	New	VECTIVBIO HLDG AG	$15,338,000	–	2,840,389	–	1.16%	–
	New	GREENLIGHT BIOSCIENCS HLDS P	$15,234,000	–	6,960,540	–	1.15%	–
STOK	New	STOKE THERAPEUTICS INC	$14,370,000	–	1,087,807	–	1.09%	–
CNTA	New	CENTESSA PHARMACEUTICALS PLCsponsored ads	$14,256,000	–	2,927,273	–	1.08%	–
BBIO	New	BRIDGEBIO PHARMA INC	$13,340,000	–	1,469,179	–	1.01%	–
RAIN	New	RAIN THERAPEUTICS INC	$12,936,000	–	2,326,660	–	0.98%	–
	New	IMMUNEERING CORP	$12,368,000	–	2,286,181	–	0.94%	–
RCKT	New	ROCKET PHARMACEUTICALS INC	$11,951,000	–	868,550	–	0.90%	–
SWTX	New	SPRINGWORKS THERAPEUTICS INC	$11,694,000	–	475,000	–	0.88%	–
AVIR	New	ATEA PHARMACEUTICALS INC	$10,985,000	–	1,547,181	–	0.83%	–
VERV	New	VERVE THERAPEUTICS INC	$10,707,000	–	700,710	–	0.81%	–
VRDN	New	VIRIDIAN THERAPEUTICS INC	$10,153,000	–	877,500	–	0.77%	–
KZR	New	KEZAR LIFE SCIENCES INC	$9,924,000	–	1,200,000	–	0.75%	–
	New	VENTYX BIOSCIENCES INC	$9,547,000	–	780,643	–	0.72%	–
OLMA	New	OLEMA PHARMACEUTICALS INC	$8,474,000	–	2,082,000	–	0.64%	–
AXSM	New	AXSOME THERAPEUTICS INC	$7,852,000	–	205,000	–	0.59%	–
LBPH	New	LONGBOARD PHARMACEUTICALS IN	$7,024,000	–	2,273,221	–	0.53%	–
COGT	New	COGENT BIOSCIENCES INC	$6,765,000	–	750,000	–	0.51%	–
AMAM	New	AMBRX BIOPHARMA INCsponsored ads	$6,589,000	–	2,486,386	–	0.50%	–
GHRS	New	GH RESEARCH PLCordinary shares	$6,069,000	–	608,123	–	0.46%	–
BCAB	New	BIOATLA INC	$5,809,000	–	2,038,215	–	0.44%	–
ALXO	New	ALX ONCOLOGY HLDGS INC	$5,761,000	–	712,079	–	0.44%	–
CLDX	New	CELLDEX THERAPEUTICS INC NEW	$5,392,000	–	200,000	–	0.41%	–
	New	TYRA BIOSCIENCES INC	$5,320,000	–	743,988	–	0.40%	–
TALS	New	TALARIS THERAPEUTICS INC	$5,298,000	–	1,174,723	–	0.40%	–
ASND	New	ASCENDIS PHARMA A/Ssponsored adr	$4,648,000	–	50,000	–	0.35%	–
PLRX	New	PLIANT THERAPEUTICS INC	$3,864,000	–	482,413	–	0.29%	–
AKRO	New	AKERO THERAPEUTICS INC	$3,816,000	–	403,787	–	0.29%	–
	New	ICOSAVAX INC	$3,732,000	–	651,393	–	0.28%	–
ELDN	New	ELEDON PHARMACEUTICALS INC	$3,184,000	–	1,305,095	–	0.24%	–
ELEV	New	ELEVATION ONCOLOGY INC	$2,776,000	–	1,983,168	–	0.21%	–
KROS	New	KEROS THERAPEUTICS INC	$2,763,000	–	100,000	–	0.21%	–
YMAB	New	Y-MABS THERAPEUTICS INC	$2,270,000	–	150,000	–	0.17%	–
AKUS	New	AKOUOS INC	$1,850,000	–	394,500	–	0.14%	–
GLTO	New	GALECTO INC	$1,765,000	–	1,020,238	–	0.13%	–
GOSS	New	GOSSAMER BIO INC	$1,660,000	–	198,382	–	0.13%	–
	New	PYXIS ONCOLOGY INC	$1,592,000	–	668,854	–	0.12%	–
	New	VIGIL NEUROSCIENCE INC	$1,591,000	–	616,786	–	0.12%	–
CABA	New	CABALETTA BIO INC	$1,224,000	–	1,154,424	–	0.09%	–
MGTX	New	MEIRAGTX HLDGS PLC	$1,136,000	–	150,000	–	0.09%	–
AUTL	New	AUTOLUS THERAPEUTICS PLCspon ads	$1,110,000	–	392,167	–	0.08%	–
CMMB	New	CHEMOMAB THERAPEUTICS LTDsponsored ads	$1,066,000	–	288,168	–	0.08%	–
HARP	New	HARPOON THERAPEUTICS INC	$1,033,000	–	540,600	–	0.08%	–
	New	RENOVACOR INC	$1,014,000	–	500,000	–	0.08%	–
ANAB	New	ANAPTYSBIO INC	$1,015,000	–	50,000	–	0.08%	–
	New	GELESIS HLDGS INC	$970,000	–	626,108	–	0.07%	–
	New	ASTRIA THERAPEUTICS INC	$900,000	–	300,000	–	0.07%	–
BCEL	New	ATRECA INC	$571,000	–	319,057	–	0.04%	–
GRPH	New	GRAPHITE BIO INC	$549,000	–	199,547	–	0.04%	–
IMV	New	IMV INC	$155,000	–	234,374	–	0.01%	–
ORTX	New	ORCHARD THERAPEUTICS PLCads	$150,000	–	256,649	–	0.01%	–
XFOR	New	X4 PHARMACEUTICALS INC	$100,000	–	103,980	–	0.01%	–

Q4 2021

			Value		Shares		↓ Weighting
OTLKW	Exit	OUTLOOK THERAPEUTICS INC*w exp 02/18/202	$0	–	-270,698	–	-0.00%	–
NERV	Exit	MINERVA NEUROSCIENCES INC	$0	–	-95,744	–	-0.01%	–
IMV	Exit	IMV INC	$0	–	-234,374	–	-0.02%	–
XFOR	Exit	X4 PHARMACEUTICALS INC	$0	–	-103,980	–	-0.02%	–
ORTX	Exit	ORCHARD THERAPEUTICS PLCads	$0	–	-256,649	–	-0.02%	–
BCEL	Exit	ATRECA INC	$0	–	-273,500	–	-0.07%	–
QTNT	Exit	QUOTIENT LTD	$0	–	-1,000,000	–	-0.10%	–
GOSS	Exit	GOSSAMER BIO INC	$0	–	-198,382	–	-0.10%	–
AUTL	Exit	AUTOLUS THERAPEUTICS PLCspon ads	$0	–	-392,167	–	-0.10%	–
SRNE	Exit	SORRENTO THERAPEUTICS INC	$0	–	-400,000	–	-0.12%	–
GRPH	Exit	GRAPHITE BIO INC	$0	–	-203,153	–	-0.13%	–
MGTA	Exit	MAGENTA THERAPEUTICS INC	$0	–	-478,200	–	-0.14%	–
DTIL	Exit	PRECISION BIOSCIENCES INC	$0	–	-346,524	–	-0.16%	–
TCRR	Exit	TCR2 THERAPEUTICS INC	$0	–	-479,506	–	-0.17%	–
GLTO	Exit	GALECTO INC	$0	–	-1,150,730	–	-0.17%	–
HARP	Exit	HARPOON THERAPEUTICS INC	$0	–	-540,600	–	-0.17%	–
HLXA	Exit	HELIX ACQUISITION CORP	$0	–	-430,000	–	-0.17%	–
	Exit	RENOVACOR INC	$0	–	-500,000	–	-0.18%	–
AKUS	Exit	AKOUOS INC	$0	–	-394,500	–	-0.19%	–
	Exit	ASTRIA THERAPEUTICS INC	$0	–	-552,903	–	-0.20%	–
DCPH	Exit	DECIPHERA PHARMACEUTICALS IN	$0	–	-144,439	–	-0.20%	–
MRUS	Exit	MERUS N V	$0	–	-250,000	–	-0.22%	–
VRDN	Exit	VIRIDIAN THERAPEUTICS INC	$0	–	-342,562	–	-0.23%	–
MORF	Exit	MORPHIC HLDG INC	$0	–	-100,000	–	-0.23%	–
	Exit	APTOSE BIOSCIENCES INC	$0	–	-3,000,000	–	-0.27%	–
MYOV	Exit	MYOVANT SCIENCES LTD	$0	–	-300,000	–	-0.27%	–
VERU	Exit	VERU INC	$0	–	-800,000	–	-0.28%	–
QURE	Exit	UNIQURE NV	$0	–	-239,548	–	-0.31%	–
ITOS	Exit	ITEOS THERAPEUTICS INC	$0	–	-288,330	–	-0.32%	–
ELDN	Exit	ELEDON PHARMACEUTICALS INC	$0	–	-1,305,095	–	-0.33%	–
PLRX	Exit	PLIANT THERAPEUTICS INC	$0	–	-482,413	–	-0.33%	–
TVTX	Exit	TRAVERE THERAPEUTICS INC	$0	–	-350,000	–	-0.34%	–
BEAM	Exit	BEAM THERAPEUTICS INC	$0	–	-100,000	–	-0.35%	–
	Exit	DERMTECH INC	$0	–	-300,000	–	-0.39%	–
RETA	Exit	REATA PHARMACEUTICALS INCcl a	$0	–	-100,000	–	-0.41%	–
ALGS	Exit	ALIGOS THERAPEUTICS INC	$0	–	-667,167	–	-0.42%	–
ANAB	Exit	ANAPTYSBIO INC	$0	–	-385,081	–	-0.42%	–
INSP	Exit	INSPIRE MED SYS INC	$0	–	-48,132	–	-0.46%	–
CNTB	Exit	CONNECT BIOPHARMA HLDGS LTDads	$0	–	-500,000	–	-0.49%	–
	Exit	ICOSAVAX INC	$0	–	-426,393	–	-0.50%	–
PHVS	Exit	PHARVARIS N V	$0	–	-689,731	–	-0.50%	–
OMER	Exit	OMEROS CORP	$0	–	-950,000	–	-0.53%	–
GHRS	Exit	GH RESEARCH PLCordinary shares	$0	–	-608,123	–	-0.53%	–
AKRO	Exit	AKERO THERAPEUTICS INC	$0	–	-600,000	–	-0.54%	–
YMAB	Exit	Y-MABS THERAPEUTICS INC	$0	–	-500,000	–	-0.58%	–
IMAB	Exit	I MABsponsored ads	$0	–	-200,000	–	-0.59%	–
ELEV	Exit	ELEVATION ONCOLOGY INC	$0	–	-1,983,165	–	-0.62%	–
BPMC	Exit	BLUEPRINT MEDICINES CORP	$0	–	-150,000	–	-0.63%	–
TALS	Exit	TALARIS THERAPEUTICS INC	$0	–	-1,215,847	–	-0.66%	–
VECT	Exit	VECTIVBIO HLDG AG	$0	–	-2,226,128	–	-0.70%	–
	Exit	TYRA BIOSCIENCES INC	$0	–	-1,069,932	–	-0.74%	–
PRAX	Exit	PRAXIS PRECISION MEDICINES I	$0	–	-1,024,161	–	-0.77%	–
CABA	Exit	CABALETTA BIO INC	$0	–	-1,611,623	–	-0.80%	–
LBPH	Exit	LONGBOARD PHARMACEUTICALS IN	$0	–	-2,273,221	–	-0.82%	–
AXNX	Exit	AXONICS INC	$0	–	-322,240	–	-0.85%	–
MRTX	Exit	MIRATI THERAPEUTICS INC	$0	–	-120,000	–	-0.86%	–
IGMS	Exit	IGM BIOSCIENCES INC	$0	–	-350,000	–	-0.94%	–
AGEN	Exit	AGENUS INC	$0	–	-4,807,557	–	-1.03%	–
ACRS	Exit	ACLARIS THERAPEUTICS INC	$0	–	-1,500,000	–	-1.10%	–
ASND	Exit	ASCENDIS PHARMA A/Ssponsored adr	$0	–	-170,000	–	-1.10%	–
ZYME	Exit	ZYMEWORKS INC	$0	–	-950,000	–	-1.12%	–
CNTA	Exit	CENTESSA PHARMACEUTICALS PLCsponsored ads	$0	–	-1,727,273	–	-1.17%	–
RCKT	Exit	ROCKET PHARMACEUTICALS INC	$0	–	-968,550	–	-1.18%	–
APLS	Exit	APELLIS PHARMACEUTICALS INC	$0	–	-925,000	–	-1.24%	–
TARS	Exit	TARSUS PHARMACEUTICALS INC	$0	–	-1,444,831	–	-1.26%	–
STOK	Exit	STOKE THERAPEUTICS INC	$0	–	-1,278,276	–	-1.32%	–
VERV	Exit	VERVE THERAPEUTICS INC	$0	–	-709,224	–	-1.33%	–
AMAM	Exit	AMBRX BIOPHARMA INCsponsored ads	$0	–	-2,486,386	–	-1.34%	–
RAIN	Exit	RAIN THERAPEUTICS INC	$0	–	-2,326,660	–	-1.41%	–
CYTK	Exit	CYTOKINETICS INC	$0	–	-1,000,000	–	-1.45%	–
BMEA	Exit	BIOMEA FUSION INC	$0	–	-3,170,872	–	-1.54%	–
AVTE	Exit	AEROVATE THERAPEUTICS INC	$0	–	-2,030,691	–	-1.70%	–
RXDX	Exit	PROMETHEUS BIOSCIENCES INC	$0	–	-1,848,024	–	-1.78%	–
	Exit	TANGO THERAPEUTICS INC	$0	–	-3,899,185	–	-1.98%	–
RNA	Exit	AVIDITY BIOSCIENCES INC	$0	–	-2,162,115	–	-2.16%	–
BCAB	Exit	BIOATLA INC	$0	–	-1,815,546	–	-2.17%	–
EWTX	Exit	EDGEWISE THERAPEUTICS INC	$0	–	-3,370,914	–	-2.27%	–
	Exit	IMMUNEERING CORP	$0	–	-2,252,626	–	-2.38%	–
GLUE	Exit	MONTE ROSA THERAPEUTICS INC	$0	–	-3,102,199	–	-2.76%	–
ALXO	Exit	ALX ONCOLOGY HLDGS INC	$0	–	-1,012,079	–	-3.04%	–
DSGN	Exit	DESIGN THERAPEUTICS INC	$0	–	-5,364,850	–	-3.20%	–
BBIO	Exit	BRIDGEBIO PHARMA INC	$0	–	-1,768,909	–	-3.37%	–
OLMA	Exit	OLEMA PHARMACEUTICALS INC	$0	–	-3,073,485	–	-3.44%	–
RVMD	Exit	REVOLUTION MEDICINES INC	$0	–	-3,144,700	–	-3.52%	–
FMTX	Exit	FORMA THERAPEUTICS HLDGS INC	$0	–	-4,720,495	–	-4.45%	–
AVIR	Exit	ATEA PHARMACEUTICALS INC	$0	–	-4,928,756	–	-7.02%	–
TPTX	Exit	TURNING POINT THERAPEUTICS I	$0	–	-2,842,297	–	-7.67%	–
	Exit	ERASCA INC	$0	–	-10,505,550	–	-8.81%	–

Q3 2021

			Value		Shares		↓ Weighting
	New	ERASCA INC	$216,845,000	–	10,505,550	–	8.81%	–
TPTX	Sell	TURNING POINT THERAPEUTICS I	$188,814,000	-20.3%	2,842,297	-6.4%	7.67%	-4.7%
AVIR	Sell	ATEA PHARMACEUTICALS INC	$172,802,000	+25.5%	4,928,756	-23.1%	7.02%	+50.1%
FMTX	Sell	FORMA THERAPEUTICS HLDGS INC	$109,468,000	-6.9%	4,720,495	-0.0%	4.45%	+11.4%
RVMD	Sell	REVOLUTION MEDICINES INC	$86,511,000	-18.3%	3,144,700	-5.8%	3.52%	-2.3%
BBIO	Sell	BRIDGEBIO PHARMA INC	$82,909,000	-27.7%	1,768,909	-6.0%	3.37%	-13.5%
DSGN	Sell	DESIGN THERAPEUTICS INC	$78,810,000	-25.6%	5,364,850	-0.9%	3.20%	-11.1%
ALXO	Buy	ALX ONCOLOGY HLDGS INC	$74,752,000	+53.7%	1,012,079	+13.8%	3.04%	+83.8%
GLUE	Sell	MONTE ROSA THERAPEUTICS INC	$67,957,000	-2.3%	3,102,199	-2.9%	2.76%	+16.8%
	New	IMMUNEERING CORP	$58,451,000	–	2,252,626	–	2.38%	–
EWTX	Buy	EDGEWISE THERAPEUTICS INC	$55,957,000	-15.9%	3,370,914	+7.3%	2.27%	+0.6%
BCAB	Sell	BIOATLA INC	$53,450,000	-35.4%	1,815,546	-7.0%	2.17%	-22.7%
RNA	Sell	AVIDITY BIOSCIENCES INC	$53,253,000	-3.3%	2,162,115	-3.0%	2.16%	+15.7%
	New	TANGO THERAPEUTICS INC	$48,814,000	–	3,899,185	–	1.98%	–
CYTK	New	CYTOKINETICS INC	$35,740,000	–	1,000,000	–	1.45%	–
RAIN	Sell	RAIN THERAPEUTICS INC	$34,807,000	-12.4%	2,326,660	-11.4%	1.41%	+4.7%
TARS	Sell	TARSUS PHARMACEUTICALS INC	$31,136,000	-29.0%	1,444,831	-4.6%	1.26%	-15.2%
APLS	Buy	APELLIS PHARMACEUTICALS INC	$30,488,000	-43.2%	925,000	+8.8%	1.24%	-32.1%
CNTA	Buy	CENTESSA PHARMACEUTICALS PLCsponsored ads	$28,724,000	-7.5%	1,727,273	+21.0%	1.17%	+10.6%
ZYME	Sell	ZYMEWORKS INC	$27,588,000	-39.8%	950,000	-28.1%	1.12%	-28.0%
ASND	Buy	ASCENDIS PHARMA A/Ssponsored adr	$27,096,000	+174.6%	170,000	+126.7%	1.10%	+228.7%
ACRS	Sell	ACLARIS THERAPEUTICS INC	$27,000,000	-23.1%	1,500,000	-25.0%	1.10%	-8.0%
IGMS	Buy	IGM BIOSCIENCES INC	$23,016,000	+10.7%	350,000	+40.0%	0.94%	+32.2%
MRTX	Sell	MIRATI THERAPEUTICS INC	$21,229,000	-24.9%	120,000	-31.4%	0.86%	-10.1%
LBPH	Sell	LONGBOARD PHARMACEUTICALS IN	$20,155,000	-3.4%	2,273,221	-2.1%	0.82%	+15.5%
PRAX	Buy	PRAXIS PRECISION MEDICINES I	$18,937,000	+1.2%	1,024,161	+0.0%	0.77%	+20.9%
	New	TYRA BIOSCIENCES INC	$18,154,000	–	1,069,932	–	0.74%	–
BPMC	Sell	BLUEPRINT MEDICINES CORP	$15,422,000	-26.2%	150,000	-36.9%	0.63%	-11.7%
IMAB	New	I MABsponsored ads	$14,498,000	–	200,000	–	0.59%	–
YMAB	Sell	Y-MABS THERAPEUTICS INC	$14,270,000	-47.2%	500,000	-37.5%	0.58%	-36.9%
OMER	Sell	OMEROS CORP	$13,100,000	-26.4%	950,000	-20.8%	0.53%	-12.1%
	New	ICOSAVAX INC	$12,238,000	–	426,393	–	0.50%	–
PHVS	Sell	PHARVARIS N V	$12,229,000	-10.3%	689,731	-7.4%	0.50%	+7.3%
CNTB	Sell	CONNECT BIOPHARMA HLDGS LTDads	$11,950,000	-5.9%	500,000	-23.1%	0.49%	+12.8%
ALGS	Sell	ALIGOS THERAPEUTICS INC	$10,348,000	-43.9%	667,167	-26.3%	0.42%	-33.0%
RETA	Sell	REATA PHARMACEUTICALS INCcl a	$10,061,000	-57.7%	100,000	-40.5%	0.41%	-49.4%
	Sell	DERMTECH INC	$9,633,000	-48.5%	300,000	-33.3%	0.39%	-38.4%
TVTX	New	TRAVERE THERAPEUTICS INC	$8,488,000	–	350,000	–	0.34%	–
ELDN	Sell	ELEDON PHARMACEUTICALS INC	$8,065,000	-28.0%	1,305,095	-7.8%	0.33%	-13.7%
MYOV	Sell	MYOVANT SCIENCES LTD	$6,732,000	-45.5%	300,000	-44.7%	0.27%	-34.8%
	Sell	APTOSE BIOSCIENCES INC	$6,540,000	-48.3%	3,000,000	-21.2%	0.27%	-38.0%
MORF	Sell	MORPHIC HLDG INC	$5,664,000	-48.0%	100,000	-47.3%	0.23%	-37.8%
VRDN	Sell	VIRIDIAN THERAPEUTICS INC	$5,635,000	-10.2%	342,562	-0.1%	0.23%	+7.5%
MRUS	Sell	MERUS N V	$5,500,000	-8.4%	250,000	-12.3%	0.22%	+9.3%
	New	ASTRIA THERAPEUTICS INC	$4,888,000	–	552,903	–	0.20%	–
	New	RENOVACOR INC	$4,525,000	–	500,000	–	0.18%	–
GLTO	Sell	GALECTO INC	$4,131,000	-53.4%	1,150,730	-34.4%	0.17%	-44.2%
SRNE	Sell	SORRENTO THERAPEUTICS INC	$3,052,000	-37.0%	400,000	-20.0%	0.12%	-24.8%
QTNT	Sell	QUOTIENT LTD	$2,340,000	-46.6%	1,000,000	-16.9%	0.10%	-36.2%
NERV	Sell	MINERVA NEUROSCIENCES INC	$167,000	-70.7%	95,744	-61.0%	0.01%	-63.2%
OTLKW	Sell	OUTLOOK THERAPEUTICS INC*w exp 02/18/202	$54,000	-58.5%	270,698	-35.0%	0.00%	-50.0%
NUVBWS	Exit	NUVATION BIO INC*w exp 07/07/202	$0	–	-83,332	–	-0.01%	–
CEREW	Exit	CEREVEL THERAPEUTICS HLDNG I*w exp 06/09/202	$0	–	-19,316	–	-0.01%	–
CRDF	Exit	CARDIFF ONCOLOGY INC	$0	–	-95,720	–	-0.02%	–
SWTX	Exit	SPRINGWORKS THERAPEUTICS INC	$0	–	-15,000	–	-0.04%	–
TCDA	Exit	TRICIDA INC	$0	–	-427,975	–	-0.06%	–
EIGR	Exit	EIGER BIOPHARMACEUTICALS INC	$0	–	-284,988	–	-0.08%	–
HSAQ	Exit	HEALTH SCIENCES ACQ CORP 2	$0	–	-240,000	–	-0.08%	–
GTH	Exit	GENETRON HLDGS LTDads	$0	–	-132,867	–	-0.09%	–
FVAM	Exit	5 01 ACQUISITION CORP	$0	–	-400,000	–	-0.14%	–
TBPH	Exit	THERAVANCE BIOPHARMA INC	$0	–	-300,000	–	-0.15%	–
AVEO	Exit	AVEO PHARMACEUTICALS INC	$0	–	-893,500	–	-0.20%	–
INSM	Exit	INSMED INC	$0	–	-250,000	–	-0.24%	–
SBTX	Exit	SILVERBACK THERAPEUTICS INC	$0	–	-239,099	–	-0.25%	–
	Exit	CATABASIS PHARMACEUTICALS IN	$0	–	-3,550,000	–	-0.25%	–
BCTG	Exit	BCTG ACQUISITION CORP	$0	–	-800,000	–	-0.31%	–
ZLAB	Exit	ZAI LAB LTDadr	$0	–	-53,455	–	-0.32%	–
HGEN	Exit	HUMANIGEN INC	$0	–	-600,000	–	-0.35%	–
RPTX	Exit	REPARE THERAPEUTICS INC	$0	–	-363,766	–	-0.38%	–
CCCC	Exit	C4 THERAPEUTICS INC	$0	–	-354,495	–	-0.46%	–
OMER	Exit	OMEROS CORPcall	$0	–	-1,000,000	–	-0.50%	–
MASS	Exit	908 DEVICES INC	$0	–	-545,320	–	-0.72%	–
XLRN	Exit	ACCELERON PHARMA INC	$0	–	-175,000	–	-0.75%	–
TWST	Exit	TWIST BIOSCIENCE CORP	$0	–	-185,000	–	-0.84%	–
ARKK	Exit	ARK ETF TRput	$0	–	-500,000	–	-2.22%	–
ARKG	Exit	ARK ETF TRput	$0	–	-750,000	–	-2.36%	–
IWM	Exit	ISHARES TRput	$0	–	-1,000,000	–	-7.79%	–

Q2 2021

			Value		Shares		↓ Weighting
TPTX	New	TURNING POINT THERAPEUTICS I	$236,950,000	–	3,037,042	–	8.05%	–
IWM	New	ISHARES TRput	$229,370,000	–	1,000,000	–	7.79%	–
AVIR	New	ATEA PHARMACEUTICALS INC	$137,716,000	–	6,411,355	–	4.68%	–
FMTX	New	FORMA THERAPEUTICS HLDGS INC	$117,520,000	–	4,721,589	–	3.99%	–
BBIO	New	BRIDGEBIO PHARMA INC	$114,665,000	–	1,880,980	–	3.90%	–
DSGN	New	DESIGN THERAPEUTICS INC	$105,965,000	–	5,414,850	–	3.60%	–
RVMD	New	REVOLUTION MEDICINES INC	$105,953,000	–	3,338,166	–	3.60%	–
OLMA	New	OLEMA PHARMACEUTICALS INC	$85,996,000	–	3,073,485	–	2.92%	–
BCAB	New	BIOATLA INC	$82,714,000	–	1,951,718	–	2.81%	–
GLUE	New	MONTE ROSA THERAPEUTICS INC	$69,550,000	–	3,193,973	–	2.36%	–
ARKG	New	ARK ETF TRput	$69,375,000	–	750,000	–	2.36%	–
EWTX	New	EDGEWISE THERAPEUTICS INC	$66,530,000	–	3,140,914	–	2.26%	–
ARKK	New	ARK ETF TRput	$65,390,000	–	500,000	–	2.22%	–
RNA	New	AVIDITY BIOSCIENCES INC	$55,070,000	–	2,228,667	–	1.87%	–
APLS	New	APELLIS PHARMACEUTICALS INC	$53,720,000	–	850,000	–	1.82%	–
ALXO	New	ALX ONCOLOGY HLDGS INC	$48,635,000	–	889,454	–	1.65%	–
BMEA	New	BIOMEA FUSION INC	$48,434,000	–	3,170,872	–	1.64%	–
AMAM	New	AMBRX BIOPHARMA INCsponsored ads	$47,032,000	–	2,486,386	–	1.60%	–
ZYME	New	ZYMEWORKS INC	$45,858,000	–	1,321,936	–	1.56%	–
AVTE	New	AEROVATE THERAPEUTICS INC	$44,613,000	–	2,030,691	–	1.52%	–
RXDX	New	PROMETHEUS BIOSCIENCES INC	$44,480,000	–	1,848,024	–	1.51%	–
TARS	New	TARSUS PHARMACEUTICALS INC	$43,884,000	–	1,514,269	–	1.49%	–
STOK	New	STOKE THERAPEUTICS INC	$43,027,000	–	1,278,276	–	1.46%	–
RCKT	New	ROCKET PHARMACEUTICALS INC	$42,897,000	–	968,550	–	1.46%	–
VERV	New	VERVE THERAPEUTICS INC	$40,594,000	–	709,224	–	1.38%	–
RAIN	New	RAIN THERAPEUTICS INC	$39,734,000	–	2,626,660	–	1.35%	–
ACRS	New	ACLARIS THERAPEUTICS INC	$35,120,000	–	2,000,000	–	1.19%	–
CNTA	New	CENTESSA PHARMACEUTICALS PLCsponsored ads	$31,054,000	–	1,427,273	–	1.06%	–
MRTX	New	MIRATI THERAPEUTICS INC	$28,268,000	–	175,000	–	0.96%	–
YMAB	New	Y-MABS THERAPEUTICS INC	$27,040,000	–	800,000	–	0.92%	–
AGEN	New	AGENUS INC	$26,393,000	–	4,807,557	–	0.90%	–
ELEV	New	ELEVATION ONCOLOGY INC	$25,566,000	–	1,983,165	–	0.87%	–
VECT	New	VECTIVBIO HLDG AG	$25,531,000	–	2,226,128	–	0.87%	–
TWST	New	TWIST BIOSCIENCE CORP	$24,651,000	–	185,000	–	0.84%	–
RETA	New	REATA PHARMACEUTICALS INCcl a	$23,798,000	–	168,150	–	0.81%	–
XLRN	New	ACCELERON PHARMA INC	$21,961,000	–	175,000	–	0.75%	–
MASS	New	908 DEVICES INC	$21,131,000	–	545,320	–	0.72%	–
BPMC	New	BLUEPRINT MEDICINES CORP	$20,895,000	–	237,546	–	0.71%	–
LBPH	New	LONGBOARD PHARMACEUTICALS IN	$20,869,000	–	2,321,403	–	0.71%	–
IGMS	New	IGM BIOSCIENCES INC	$20,800,000	–	250,000	–	0.71%	–
AXNX	New	AXONICS INC	$20,433,000	–	322,240	–	0.69%	–
PRAX	New	PRAXIS PRECISION MEDICINES I	$18,721,000	–	1,024,145	–	0.64%	–
	New	DERMTECH INC	$18,706,000	–	450,000	–	0.64%	–
ALGS	New	ALIGOS THERAPEUTICS INC	$18,458,000	–	905,467	–	0.63%	–
OMER	New	OMEROS CORP	$17,808,000	–	1,200,000	–	0.60%	–
TALS	New	TALARIS THERAPEUTICS INC	$17,264,000	–	1,215,847	–	0.59%	–
AKRO	New	AKERO THERAPEUTICS INC	$14,886,000	–	600,000	–	0.51%	–
OMER	New	OMEROS CORPcall	$14,840,000	–	1,000,000	–	0.50%	–
PLRX	New	PLIANT THERAPEUTICS INC	$14,048,000	–	482,413	–	0.48%	–
CABA	New	CABALETTA BIO INC	$13,860,000	–	1,611,623	–	0.47%	–
PHVS	New	PHARVARIS N V	$13,634,000	–	744,863	–	0.46%	–
CCCC	New	C4 THERAPEUTICS INC	$13,414,000	–	354,495	–	0.46%	–
BEAM	New	BEAM THERAPEUTICS INC	$12,871,000	–	100,000	–	0.44%	–
CNTB	New	CONNECT BIOPHARMA HLDGS LTDads	$12,694,000	–	650,000	–	0.43%	–
	New	APTOSE BIOSCIENCES INC	$12,640,000	–	3,807,200	–	0.43%	–
GHRS	New	GH RESEARCH PLCordinary shares	$12,554,000	–	608,123	–	0.43%	–
MYOV	New	MYOVANT SCIENCES LTD	$12,353,000	–	542,499	–	0.42%	–
RPTX	New	REPARE THERAPEUTICS INC	$11,342,000	–	363,766	–	0.38%	–
ELDN	New	ELEDON PHARMACEUTICALS INC	$11,197,000	–	1,415,500	–	0.38%	–
MORF	New	MORPHIC HLDG INC	$10,891,000	–	189,774	–	0.37%	–
HGEN	New	HUMANIGEN INC	$10,428,000	–	600,000	–	0.35%	–
ANAB	New	ANAPTYSBIO INC	$9,985,000	–	385,081	–	0.34%	–
ASND	New	ASCENDIS PHARMA A/Ssponsored adr	$9,866,000	–	75,000	–	0.34%	–
ZLAB	New	ZAI LAB LTDadr	$9,461,000	–	53,455	–	0.32%	–
INSP	New	INSPIRE MED SYS INC	$9,302,000	–	48,132	–	0.32%	–
BCTG	New	BCTG ACQUISITION CORP	$9,096,000	–	800,000	–	0.31%	–
GLTO	New	GALECTO INC	$8,874,000	–	1,753,839	–	0.30%	–
TCRR	New	TCR2 THERAPEUTICS INC	$7,869,000	–	479,506	–	0.27%	–
HARP	New	HARPOON THERAPEUTICS INC	$7,498,000	–	540,600	–	0.26%	–
	New	CATABASIS PHARMACEUTICALS IN	$7,490,000	–	3,550,000	–	0.25%	–
SBTX	New	SILVERBACK THERAPEUTICS INC	$7,386,000	–	239,099	–	0.25%	–
QURE	New	UNIQURE NV	$7,378,000	–	239,548	–	0.25%	–
ITOS	New	ITEOS THERAPEUTICS INC	$7,396,000	–	288,330	–	0.25%	–
INSM	New	INSMED INC	$7,115,000	–	250,000	–	0.24%	–
VERU	New	VERU INC	$6,456,000	–	800,000	–	0.22%	–
VRDN	New	VIRIDIAN THERAPEUTICS INC	$6,273,000	–	342,962	–	0.21%	–
MRUS	New	MERUS N V	$6,007,000	–	285,096	–	0.20%	–
GRPH	New	GRAPHITE BIO INC	$5,931,000	–	203,153	–	0.20%	–
AVEO	New	AVEO PHARMACEUTICALS INC	$5,888,000	–	893,500	–	0.20%	–
DCPH	New	DECIPHERA PHARMACEUTICALS IN	$5,288,000	–	144,439	–	0.18%	–
AKUS	New	AKOUOS INC	$4,951,000	–	394,500	–	0.17%	–
SRNE	New	SORRENTO THERAPEUTICS INC	$4,845,000	–	500,000	–	0.16%	–
MGTA	New	MAGENTA THERAPEUTICS INC	$4,677,000	–	478,200	–	0.16%	–
HLXA	New	HELIX ACQUISITION CORP	$4,450,000	–	430,000	–	0.15%	–
QTNT	New	QUOTIENT LTD	$4,380,000	–	1,203,328	–	0.15%	–
TBPH	New	THERAVANCE BIOPHARMA INC	$4,356,000	–	300,000	–	0.15%	–
DTIL	New	PRECISION BIOSCIENCES INC	$4,338,000	–	346,524	–	0.15%	–
FVAM	New	5 01 ACQUISITION CORP	$3,988,000	–	400,000	–	0.14%	–
GTH	New	GENETRON HLDGS LTDads	$2,676,000	–	132,867	–	0.09%	–
AUTL	New	AUTOLUS THERAPEUTICS PLCspon ads	$2,604,000	–	392,167	–	0.09%	–
HSAQ	New	HEALTH SCIENCES ACQ CORP 2	$2,448,000	–	240,000	–	0.08%	–
EIGR	New	EIGER BIOPHARMACEUTICALS INC	$2,428,000	–	284,988	–	0.08%	–
BCEL	New	ATRECA INC	$2,330,000	–	273,500	–	0.08%	–
TCDA	New	TRICIDA INC	$1,849,000	–	427,975	–	0.06%	–
GOSS	New	GOSSAMER BIO INC	$1,611,000	–	198,382	–	0.06%	–
SWTX	New	SPRINGWORKS THERAPEUTICS INC	$1,236,000	–	15,000	–	0.04%	–
ORTX	New	ORCHARD THERAPEUTICS PLCads	$1,127,000	–	256,649	–	0.04%	–
XFOR	New	X4 PHARMACEUTICALS INC	$676,000	–	103,980	–	0.02%	–
CRDF	New	CARDIFF ONCOLOGY INC	$637,000	–	95,720	–	0.02%	–
NERV	New	MINERVA NEUROSCIENCES INC	$570,000	–	245,744	–	0.02%	–
IMV	New	IMV INC	$507,000	–	234,374	–	0.02%	–
CEREW	New	CEREVEL THERAPEUTICS HLDNG I*w exp 06/09/202	$278,000	–	19,316	–	0.01%	–
NUVBWS	New	NUVATION BIO INC*w exp 07/07/202	$217,000	–	83,332	–	0.01%	–
OTLKW	New	OUTLOOK THERAPEUTICS INC*w exp 02/18/202	$130,000	–	416,666	–	0.00%	–

Q4 2020

			Value		Shares		↓ Weighting
OTLKW	Exit	OUTLOOK THERAPEUTICS INC*w exp 02/18/202	$0	–	-416,666	–	-0.00%	–
FATE	Exit	FATE THERAPEUTICS INC	$0	–	-15,000	–	-0.02%	–
NERV	Exit	MINERVA NEUROSCIENCES INC	$0	–	-238,817	–	-0.03%	–
NKTR	Exit	NEKTAR THERAPEUTICS	$0	–	-50,000	–	-0.03%	–
ORTX	Exit	ORCHARD THERAPEUTICS PLCads	$0	–	-256,649	–	-0.04%	–
AMRN	Exit	AMARIN CORP PLCspons adr new	$0	–	-300,000	–	-0.05%	–
DTIL	Exit	PRECISION BIOSCIENCES INC	$0	–	-346,524	–	-0.08%	–
ARNA	Exit	ARENA PHARMACEUTICALS INC	$0	–	-30,000	–	-0.09%	–
CRDF	Exit	CARDIFF ONCOLOGY INC	$0	–	-175,000	–	-0.10%	–
PANAU	Exit	PANACEA ACQUISITION CORPunit 99/99/9999	$0	–	-250,000	–	-0.12%	–
GOSS	Exit	GOSSAMER BIO INC	$0	–	-248,382	–	-0.12%	–
AVRO	Exit	AVROBIO INC	$0	–	-244,032	–	-0.12%	–
EIGR	Exit	EIGER BIOPHARMACEUTICALS INC	$0	–	-449,510	–	-0.14%	–
KDMN	Exit	KADMON HOLDINGS INC	$0	–	-1,000,000	–	-0.15%	–
BCEL	Exit	ATRECA INC	$0	–	-293,500	–	-0.16%	–
VSPRU	Exit	VESPER HEALTHCARE ACQSTN CORunit 99/99/9999	$0	–	-400,000	–	-0.16%	–
KZR	Exit	KEZAR LIFE SCIENCES INC	$0	–	-931,800	–	-0.17%	–
AUTL	Exit	AUTOLUS THERAPEUTICS PLCspon ads	$0	–	-422,167	–	-0.19%	–
FIXX	Exit	HOMOLOGY MEDICINES INC	$0	–	-470,897	–	-0.19%	–
MRUS	Exit	MERUS N V	$0	–	-429,284	–	-0.20%	–
SRNE	Exit	SORRENTO THERAPEUTICS INCcall	$0	–	-500,000	–	-0.21%	–
FSDC	Exit	FS DEV CORP	$0	–	-500,000	–	-0.22%	–
AVEO	Exit	AVEO PHARMACEUTICALS INC	$0	–	-1,000,000	–	-0.23%	–
GTH	Exit	GENETRON HLDGS LTDads	$0	–	-500,000	–	-0.23%	–
ALLK	Exit	ALLAKOS INC	$0	–	-75,000	–	-0.24%	–
TCDA	Exit	TRICIDA INC	$0	–	-727,975	–	-0.25%	–
MORF	Exit	MORPHIC HLDG INC	$0	–	-250,000	–	-0.26%	–
RACA	Exit	THERAPEUTICS ACQUISITION COR	$0	–	-500,000	–	-0.28%	–
TARA	Exit	PROTARA THERAPEUTIC INC	$0	–	-450,000	–	-0.29%	–
BCTG	Exit	BCTG ACQUISITION CORP	$0	–	-800,000	–	-0.32%	–
ITOS	Exit	ITEOS THERAPEUTICS INC	$0	–	-350,000	–	-0.33%	–
HSAQ	Exit	HEALTH SCIENCES ACQ CORP 2	$0	–	-800,000	–	-0.34%	–
ANAB	Exit	ANAPTYSBIO INC	$0	–	-650,000	–	-0.37%	–
TBPH	Exit	THERAVANCE BIOPHARMA INC	$0	–	-650,072	–	-0.37%	–
HARP	Exit	HARPOON THERAPEUTICS INC	$0	–	-570,600	–	-0.37%	–
OMER	Exit	OMEROS CORPcall	$0	–	-1,000,000	–	-0.39%	–
QTNT	Exit	QUOTIENT LTD	$0	–	-2,000,000	–	-0.40%	–
ARGX	Exit	ARGENX SEsponsored adr	$0	–	-40,000	–	-0.40%	–
RPTX	Exit	REPARE THERAPEUTICS INC	$0	–	-348,567	–	-0.41%	–
AKUS	Exit	AKOUOS INC	$0	–	-499,991	–	-0.43%	–
INSM	Exit	INSMED INC	$0	–	-350,000	–	-0.43%	–
SRPT	Exit	SAREPTA THERAPEUTICS INC(NSM)	$0	–	-85,000	–	-0.46%	–
QURE	Exit	UNIQURE NV	$0	–	-325,000	–	-0.46%	–
TCRR	Exit	TCR2 THERAPEUTICS INC	$0	–	-600,000	–	-0.47%	–
DCPH	Exit	DECIPHERA PHARMACEUTICALS IN	$0	–	-250,000	–	-0.49%	–
OTIC	Exit	OTONOMY INC	$0	–	-3,241,800	–	-0.50%	–
PLRX	Exit	PLIANT THERAPEUTICS, INC	$0	–	-611,409	–	-0.52%	–
CCXI	Exit	CHEMOCENTRYX INCcall	$0	–	-250,000	–	-0.53%	–
KURA	Exit	KURA ONCOLOGY INC	$0	–	-500,000	–	-0.59%	–
INSP	Exit	INSPIRE MED SYS INC	$0	–	-120,000	–	-0.60%	–
ZLAB	Exit	ZAI LAB LTDadr	$0	–	-189,092	–	-0.60%	–
IGMS	Exit	IGM BIOSCIENCES INC	$0	–	-225,000	–	-0.64%	–
AXSM	Exit	AXSOME THERAPEUTICS INC	$0	–	-250,000	–	-0.68%	–
GLPG	Exit	GALAPAGOS NVspon adr	$0	–	-130,000	–	-0.71%	–
ASND	Exit	ASCENDIS PHARMA A/Ssponsored adr	$0	–	-125,000	–	-0.74%	–
BEAM	Exit	BEAM THERAPEUTICS INC	$0	–	-796,428	–	-0.75%	–
BNTX	Exit	BIONTECH SEsponsored ads	$0	–	-325,000	–	-0.86%	–
CABA	Exit	CABALETTA BIO INC	$0	–	-2,067,302	–	-0.86%	–
ALBO	Exit	ALBIREO PHARMA INC	$0	–	-700,000	–	-0.90%	–
CRSP	Exit	CRISPR THERAPEUTICS AGnamen akt	$0	–	-300,000	–	-0.96%	–
BPMC	Exit	BLUEPRINT MEDICINES CORP	$0	–	-275,000	–	-0.98%	–
AKRO	Exit	AKERO THERAPEUTICS INC	$0	–	-859,550	–	-1.02%	–
MYOV	Exit	MYOVANT SCIENCES LTD	$0	–	-2,134,966	–	-1.15%	–
ARCT	Exit	ARCTURUS THERAPEUTICS HLDGS	$0	–	-700,000	–	-1.16%	–
RCKT	Exit	ROCKET PHARMACEUTICALS INC	$0	–	-1,368,550	–	-1.20%	–
BHVN	Exit	BIOHAVEN PHARMACTL HLDG CO L	$0	–	-500,000	–	-1.25%	–
AGEN	Exit	AGENUS INC	$0	–	-8,500,000	–	-1.31%	–
AXNX	Exit	AXONICS MODULATION TECHNOLOG	$0	–	-693,000	–	-1.36%	–
	Exit	TRILLIUM THERAPEUTICS INC	$0	–	-2,500,000	–	-1.37%	–
ALXO	Exit	ALX ONCOLOGY HLDGS INC	$0	–	-971,770	–	-1.38%	–
TWST	Exit	TWIST BIOSCIENCE CORP	$0	–	-500,000	–	-1.46%	–
RETA	Exit	REATA PHARMACEUTICALS INCcl a	$0	–	-450,000	–	-1.69%	–
VIE	Exit	VIELA BIO INC	$0	–	-1,585,000	–	-1.71%	–
MRTX	Exit	MIRATI THERAPEUTICS INC	$0	–	-275,000	–	-1.76%	–
EIDX	Exit	EIDOS THERAPEUTICS INC	$0	–	-993,185	–	-1.93%	–
OMER	Exit	OMEROS CORP	$0	–	-5,000,000	–	-1.94%	–
STOK	Exit	STOKE THERAPEUTICS INC	$0	–	-1,537,807	–	-1.98%	–
ZYME	Exit	ZYMEWORKS INC	$0	–	-1,150,000	–	-2.06%	–
YMAB	Exit	Y-MABS THERAPEUTICS INC	$0	–	-1,397,700	–	-2.06%	–
XBI	Exit	SPDR SER TRput	$0	–	-500,000	–	-2.14%	–
XLRN	Exit	ACCELERON PHARMA INC	$0	–	-500,000	–	-2.16%	–
APLS	Exit	APELLIS PHARMACEUTICALS INC	$0	–	-1,866,108	–	-2.16%	–
IMVT	Exit	IMMUNOVANT INC	$0	–	-1,637,951	–	-2.22%	–
MYOK	Exit	MYOKARDIA INC	$0	–	-450,000	–	-2.36%	–
SRNE	Exit	SORRENTO THERAPEUTICS INC	$0	–	-6,000,000	–	-2.57%	–
RNA	Exit	AVIDITY BIOSCIENCES INC	$0	–	-2,514,546	–	-2.67%	–
IWM	Exit	ISHARES TRput	$0	–	-500,000	–	-2.88%	–
CCXI	Exit	CHEMOCENTRYX INC	$0	–	-1,400,000	–	-2.95%	–
BBIO	Exit	BRIDGEBIO PHARMA INC	$0	–	-2,265,762	–	-3.27%	–
RVMD	Exit	REVOLUTION MEDICINES INC	$0	–	-2,640,177	–	-3.53%	–
FMTX	Exit	FORMA THERAPEUTICS HLDGS INC	$0	–	-3,379,373	–	-6.40%	–
SPY	Exit	SPDR S&P 500 ETF TRput	$0	–	-500,000	–	-6.44%	–
TPTX	Exit	TURNING POINT THERAPEUTICS I	$0	–	-2,442,297	–	-8.20%	–

Q3 2020

			Value		Shares		↓ Weighting
TPTX	Sell	TURNING POINT THERAPEUTICS I	$213,359,000	+20.7%	2,442,297	-10.8%	8.20%	+21.6%
RVMD	Buy	REVOLUTION MEDICINES INC	$91,878,000	+11.0%	2,640,177	+0.1%	3.53%	+11.9%
BBIO	Sell	BRIDGEBIO PHARMA INC	$85,011,000	+0.6%	2,265,762	-12.5%	3.27%	+1.4%
CCXI	Sell	CHEMOCENTRYX INC	$76,720,000	-21.6%	1,400,000	-17.6%	2.95%	-21.0%
RNA	Sell	AVIDITY BIOSCIENCES INC	$69,538,000	+2.6%	2,514,546	-0.0%	2.67%	+3.4%
SRNE	Sell	SORRENTO THERAPEUTICS INC	$66,900,000	+63.9%	6,000,000	-7.7%	2.57%	+65.1%
MYOK	Sell	MYOKARDIA INC	$61,349,000	+5.8%	450,000	-25.0%	2.36%	+6.6%
IMVT	New	IMMUNOVANT INC	$57,639,000	–	1,637,951	–	2.22%	–
APLS	Sell	APELLIS PHARMACEUTICALS INC	$56,300,000	-16.6%	1,866,108	-9.7%	2.16%	-15.9%
XLRN	Sell	ACCELERON PHARMA INC	$56,265,000	-1.6%	500,000	-16.7%	2.16%	-0.8%
YMAB	Sell	Y-MABS THERAPEUTICS INC	$53,658,000	-21.1%	1,397,700	-11.2%	2.06%	-20.5%
ZYME	Buy	ZYMEWORKS INC	$53,567,000	+170.0%	1,150,000	+109.1%	2.06%	+172.1%
STOK	Sell	STOKE THERAPEUTICS INC	$51,501,000	+27.0%	1,537,807	-9.6%	1.98%	+28.0%
OMER	Buy	OMEROS CORP	$50,525,000	+23.7%	5,000,000	+80.2%	1.94%	+24.6%
EIDX	Sell	EIDOS THERAPEUTICS INC	$50,186,000	-0.2%	993,185	-5.9%	1.93%	+0.6%
MRTX	Sell	MIRATI THERAPEUTICS INC	$45,664,000	-20.0%	275,000	-45.0%	1.76%	-19.4%
VIE	Buy	VIELA BIO INC	$44,507,000	-32.1%	1,585,000	+4.8%	1.71%	-31.6%
RETA	Buy	REATA PHARMACEUTICALS INCcl a	$43,839,000	-29.8%	450,000	+12.5%	1.69%	-29.2%
TWST	Sell	TWIST BIOSCIENCE CORP	$37,985,000	+51.7%	500,000	-9.6%	1.46%	+52.8%
ALXO	New	ALX ONCOLOGY HLDGS INC	$35,959,000	–	971,770	–	1.38%	–
	New	TRILLIUM THERAPEUTICS INC	$35,525,000	–	2,500,000	–	1.37%	–
AXNX	Sell	AXONICS MODULATION TECHNOLOG	$35,371,000	+39.8%	693,000	-3.8%	1.36%	+40.9%
AGEN	Sell	AGENUS INC	$34,000,000	-21.4%	8,500,000	-22.7%	1.31%	-20.7%
BHVN	Sell	BIOHAVEN PHARMACTL HLDG CO L	$32,505,000	-25.9%	500,000	-16.7%	1.25%	-25.3%
RCKT	Sell	ROCKET PHARMACEUTICALS INC	$31,285,000	+1.8%	1,368,550	-6.8%	1.20%	+2.6%
ARCT	Sell	ARCTURUS THERAPEUTICS HLDGS	$30,030,000	-19.7%	700,000	-12.5%	1.16%	-19.1%
MYOV	Sell	MYOVANT SCIENCES LTD	$29,996,000	-41.8%	2,134,966	-14.6%	1.15%	-41.4%
AKRO	Buy	AKERO THERAPEUTICS INC	$26,466,000	+79.2%	859,550	+45.1%	1.02%	+80.8%
BPMC	Sell	BLUEPRINT MEDICINES CORP	$25,493,000	-6.6%	275,000	-21.4%	0.98%	-6.0%
CRSP	Sell	CRISPR THERAPEUTICS AGnamen akt	$25,092,000	-14.6%	300,000	-25.0%	0.96%	-14.0%
ALBO	New	ALBIREO PHARMA INC	$23,359,000	–	700,000	–	0.90%	–
CABA	Sell	CABALETTA BIO INC	$22,410,000	-4.5%	2,067,302	-1.8%	0.86%	-3.7%
BNTX	Buy	BIONTECH SEsponsored ads	$22,410,000	+91.9%	325,000	+85.7%	0.86%	+93.3%
BEAM	Sell	BEAM THERAPEUTICS INC	$19,608,000	-11.0%	796,428	-0.0%	0.75%	-10.3%
ASND	Sell	ASCENDIS PHARMA A/Ssponsored adr	$19,290,000	-25.5%	125,000	-28.6%	0.74%	-24.9%
GLPG	Buy	GALAPAGOS NVspon adr	$18,471,000	-5.2%	130,000	+31.2%	0.71%	-4.4%
AXSM	Sell	AXSOME THERAPEUTICS INC	$17,813,000	-38.1%	250,000	-28.6%	0.68%	-37.7%
IGMS	Sell	IGM BIOSCIENCES INC	$16,607,000	-33.1%	225,000	-33.9%	0.64%	-32.5%
ZLAB	Sell	ZAI LAB LTDadr	$15,727,000	-23.4%	189,092	-24.4%	0.60%	-22.7%
INSP	Sell	INSPIRE MED SYS INC	$15,486,000	+20.3%	120,000	-18.9%	0.60%	+21.2%
KURA	Sell	KURA ONCOLOGY INC	$15,320,000	+34.3%	500,000	-28.6%	0.59%	+35.4%
CCXI	Sell	CHEMOCENTRYX INCcall	$13,700,000	-76.2%	250,000	-75.0%	0.53%	-76.0%
OTIC	New	OTONOMY INC	$13,129,000	–	3,241,800	–	0.50%	–
DCPH	Sell	DECIPHERA PHARMACEUTICALS IN	$12,825,000	-32.7%	250,000	-21.6%	0.49%	-32.2%
TCRR	New	TCR2 THERAPEUTICS INC	$12,192,000	–	600,000	–	0.47%	–
QURE	Sell	UNIQURE NV	$11,970,000	-40.2%	325,000	-26.8%	0.46%	-39.8%
SRPT	Sell	SAREPTA THERAPEUTICS INC(NSM)	$11,937,000	-32.3%	85,000	-22.7%	0.46%	-31.8%
INSM	Sell	INSMED INC	$11,249,000	-9.2%	350,000	-22.2%	0.43%	-8.5%
AKUS	Buy	AKOUOS INC	$11,206,000	+5.0%	499,991	+0.0%	0.43%	+5.9%
RPTX	Sell	REPARE THERAPEUTICS INC	$10,725,000	-2.0%	348,567	-1.2%	0.41%	-1.4%
ARGX	Sell	ARGENX SEsponsored adr	$10,501,000	-33.4%	40,000	-42.9%	0.40%	-32.9%
QTNT	Sell	QUOTIENT LTD	$10,280,000	-52.1%	2,000,000	-31.0%	0.40%	-51.8%
OMER	New	OMEROS CORPcall	$10,110,000	–	1,000,000	–	0.39%	–
HARP	Sell	HARPOON THERAPEUTICS INC	$9,694,000	-9.5%	570,600	-11.6%	0.37%	-8.8%
TBPH	Buy	THERAVANCE BIOPHARMA INC	$9,611,000	+357.9%	650,072	+550.1%	0.37%	+362.5%
ANAB	Sell	ANAPTYSBIO INC	$9,588,000	-51.6%	650,000	-26.6%	0.37%	-51.1%
HSAQ	New	HEALTH SCIENCES ACQ CORP 2	$8,800,000	–	800,000	–	0.34%	–
ITOS	New	ITEOS THERAPEUTICS INC	$8,635,000	–	350,000	–	0.33%	–
BCTG	New	BCTG ACQUISITION CORP	$8,365,000	–	800,000	–	0.32%	–
TARA	New	PROTARA THERAPEUTIC INC	$7,574,000	–	450,000	–	0.29%	–
RACA	New	THERAPEUTICS ACQUISITION COR	$7,190,000	–	500,000	–	0.28%	–
MORF	New	MORPHIC HLDG INC	$6,835,000	–	250,000	–	0.26%	–
TCDA	Sell	TRICIDA INC	$6,595,000	-72.5%	727,975	-16.5%	0.25%	-72.2%
ALLK	Sell	ALLAKOS INC	$6,109,000	-57.0%	75,000	-62.0%	0.24%	-56.6%
AVEO	Sell	AVEO PHARMACEUTICALS INC	$5,940,000	-14.6%	1,000,000	-25.9%	0.23%	-14.0%
FSDC	New	FS DEV CORP	$5,599,000	–	500,000	–	0.22%	–
SRNE	New	SORRENTO THERAPEUTICS INCcall	$5,575,000	–	500,000	–	0.21%	–
MRUS	Sell	MERUS N V	$5,151,000	-46.6%	429,284	-28.5%	0.20%	-46.2%
FIXX	Sell	HOMOLOGY MEDICINES INC	$5,039,000	-39.7%	470,897	-14.4%	0.19%	-39.2%
AUTL	Sell	AUTOLUS THERAPEUTICS PLCspon ads	$4,914,000	-36.1%	422,167	-12.0%	0.19%	-35.7%
KZR	Sell	KEZAR LIFE SCIENCES INC	$4,510,000	-33.0%	931,800	-28.3%	0.17%	-32.7%
VSPRU	New	VESPER HEALTHCARE ACQSTN CORunit 99/99/9999	$4,104,000	–	400,000	–	0.16%	–
BCEL	Sell	ATRECA INC	$4,100,000	-40.0%	293,500	-8.7%	0.16%	-39.5%
KDMN	Sell	KADMON HOLDINGS INC	$3,920,000	-57.5%	1,000,000	-44.4%	0.15%	-57.1%
EIGR	Sell	EIGER BIOPHARMACEUTICALS INC	$3,659,000	-45.6%	449,510	-35.8%	0.14%	-44.9%
AVRO	Sell	AVROBIO INC	$3,177,000	-42.7%	244,032	-23.2%	0.12%	-42.2%
GOSS	Sell	GOSSAMER BIO INC	$3,082,000	-32.1%	248,382	-28.9%	0.12%	-31.2%
PANAU	New	PANACEA ACQUISITION CORPunit 99/99/9999	$3,000,000	–	250,000	–	0.12%	–
CRDF	New	CARDIFF ONCOLOGY INC	$2,483,000	–	175,000	–	0.10%	–
ARNA	Sell	ARENA PHARMACEUTICALS INC	$2,244,000	-52.5%	30,000	-60.0%	0.09%	-52.2%
AMRN	Sell	AMARIN CORP PLCspons adr new	$1,263,000	-69.6%	300,000	-50.0%	0.05%	-69.0%
NKTR	Sell	NEKTAR THERAPEUTICS	$830,000	-71.3%	50,000	-60.0%	0.03%	-70.9%
NERV	Sell	MINERVA NEUROSCIENCES INC	$759,000	-59.0%	238,817	-53.4%	0.03%	-59.2%
FATE	Sell	FATE THERAPEUTICS INC	$600,000	-65.0%	15,000	-70.0%	0.02%	-64.6%
XFOR	Exit	X4 PHARMACEUTICALS INC -CW24	$0	–	-328,980	–	-0.07%	–
ARYBU	Exit	ARYA SCIENCES ACQUISITION COunit 06/09/2027	$0	–	-400,000	–	-0.18%	–
BNR	Exit	BURNING ROCK BIOTECH LTDsponsored ads	$0	–	-250,000	–	-0.26%	–
NXTC	Exit	NEXTCURE INC	$0	–	-693,971	–	-0.57%	–
STSA	Exit	SATSUMA PHARMACEUTICALS INC	$0	–	-798,905	–	-0.88%	–
PRNB	Exit	PRINCIPIA BIOPHARMA INC	$0	–	-1,590,493	–	-3.63%	–

Q2 2020

			Value		Shares		↓ Weighting
TPTX	New	TURNING POINT THERAPEUTICS I	$176,802,000	–	2,737,297	–	6.75%	–
SPY	New	SPDR S&P 500 ETF TRput	$154,180,000	–	500,000	–	5.88%	–
FMTX	New	FORMA THERAPEUTICS HLDGS INC	$152,547,000	–	3,379,373	–	5.82%	–
CCXI	New	CHEMOCENTRYX INC	$97,818,000	–	1,700,000	–	3.73%	–
PRNB	New	PRINCIPIA BIOPHARMA INC	$95,096,000	–	1,590,493	–	3.63%	–
BBIO	New	BRIDGEBIO PHARMA INC	$84,485,000	–	2,590,762	–	3.22%	–
RVMD	New	REVOLUTION MEDICINES INC	$82,737,000	–	2,636,661	–	3.16%	–
IWM	New	ISHARES TRput	$71,590,000	–	500,000	–	2.73%	–
YMAB	New	Y-MABS THERAPEUTICS INC	$68,026,000	–	1,574,683	–	2.60%	–
RNA	New	AVIDITY BIOSCIENCES INC	$67,804,000	–	2,514,547	–	2.59%	–
APLS	New	APELLIS PHARMACEUTICALS INC	$67,479,000	–	2,066,108	–	2.58%	–
VIE	New	VIELA BIO INC	$65,522,000	–	1,512,500	–	2.50%	–
RETA	New	REATA PHARMACEUTICALS INCcl a	$62,408,000	–	400,000	–	2.38%	–
MYOK	New	MYOKARDIA INC	$57,972,000	–	600,000	–	2.21%	–
CCXI	New	CHEMOCENTRYX INCcall	$57,540,000	–	1,000,000	–	2.20%	–
XLRN	New	ACCELERON PHARMA INC	$57,162,000	–	600,000	–	2.18%	–
MRTX	New	MIRATI THERAPEUTICS INC	$57,085,000	–	500,000	–	2.18%	–
XBI	New	SPDR SER TRput	$55,975,000	–	500,000	–	2.14%	–
MYOV	New	MYOVANT SCIENCES LTD	$51,550,000	–	2,500,000	–	1.97%	–
EIDX	New	EIDOS THERAPEUTICS INC	$50,306,000	–	1,055,302	–	1.92%	–
BHVN	New	BIOHAVEN PHARMACTL HLDG CO L	$43,866,000	–	600,000	–	1.67%	–
AGEN	New	AGENUS INC	$43,230,000	–	11,000,000	–	1.65%	–
OMER	New	OMEROS CORP	$40,848,000	–	2,775,000	–	1.56%	–
SRNE	New	SORRENTO THERAPEUTICS INC	$40,820,000	–	6,500,000	–	1.56%	–
STOK	New	STOKE THERAPEUTICS INC	$40,542,000	–	1,701,292	–	1.55%	–
ARCT	New	ARCTURUS THERAPEUTICS HLDG I	$37,392,000	–	800,000	–	1.43%	–
RCKT	New	ROCKET PHARMACEUTICALS INC	$30,737,000	–	1,468,550	–	1.17%	–
CRSP	New	CRISPR THERAPEUTICS AGnamen akt	$29,396,000	–	400,000	–	1.12%	–
AXSM	New	AXSOME THERAPEUTICS INC	$28,798,000	–	350,000	–	1.10%	–
BPMC	New	BLUEPRINT MEDICINES CORP	$27,300,000	–	350,000	–	1.04%	–
ASND	New	ASCENDIS PHARMA A Ssponsored adr	$25,883,000	–	175,000	–	0.99%	–
AXNX	New	AXONICS MODULATION TECHNOLOG	$25,293,000	–	720,397	–	0.96%	–
TWST	New	TWIST BIOSCIENCE CORP	$25,044,000	–	552,849	–	0.96%	–
IGMS	New	IGM BIOSCIENCES INC	$24,831,000	–	340,146	–	0.95%	–
TCDA	New	TRICIDA INC	$23,966,000	–	872,137	–	0.91%	–
CABA	New	CABALETTA BIO INC	$23,459,000	–	2,105,844	–	0.90%	–
STSA	New	SATSUMA PHARMACEUTICALS INC	$22,977,000	–	798,905	–	0.88%	–
BEAM	New	BEAM THERAPEUTICS INC	$22,036,000	–	796,429	–	0.84%	–
QTNT	New	QUOTIENT LTD	$21,463,000	–	2,900,399	–	0.82%	–
ZLAB	New	ZAI LAB LTDadr	$20,533,000	–	250,000	–	0.78%	–
QURE	New	UNIQURE NV	$20,014,000	–	444,157	–	0.76%	–
ZYME	New	ZYMEWORKS INC	$19,839,000	–	550,000	–	0.76%	–
ANAB	New	ANAPTYSBIO INC	$19,790,000	–	885,838	–	0.76%	–
GLPG	New	GALAPAGOS NVspon adr	$19,484,000	–	99,075	–	0.74%	–
DCPH	New	DECIPHERA PHARMACEUTICALS IN	$19,046,000	–	318,914	–	0.73%	–
PLRX	New	PLIANT THERAPEUTICS, INC	$18,812,000	–	611,409	–	0.72%	–
SRPT	New	SAREPTA THERAPEUTICS INC	$17,637,000	–	110,000	–	0.67%	–
ARGX	New	ARGENX SEsponsored adr	$15,766,000	–	70,000	–	0.60%	–
NXTC	New	NEXTCURE INC	$14,879,000	–	693,971	–	0.57%	–
AKRO	New	AKERO THERAPEUTICS INC	$14,766,000	–	592,539	–	0.56%	–
ALLK	New	ALLAKOS INC	$14,193,000	–	197,515	–	0.54%	–
INSP	New	INSPIRE MED SYS INC	$12,877,000	–	147,982	–	0.49%	–
INSM	New	INSMED INC	$12,393,000	–	450,000	–	0.47%	–
BNTX	New	BIONTECH SEsponsored ads	$11,680,000	–	175,000	–	0.45%	–
KURA	New	KURA ONCOLOGY INC	$11,410,000	–	700,000	–	0.44%	–
RPTX	New	REPARE THERAPEUTICS INC	$10,944,000	–	352,795	–	0.42%	–
HARP	New	HARPOON THERAPEUTICS INC	$10,711,000	–	645,257	–	0.41%	–
AKUS	New	AKOUOS INC	$10,670,000	–	499,990	–	0.41%	–
MRUS	New	MERUS N V	$9,654,000	–	600,000	–	0.37%	–
KDMN	New	KADMON HLDGS INC	$9,216,000	–	1,800,000	–	0.35%	–
FIXX	New	HOMOLOGY MEDICINES INC	$8,355,000	–	550,000	–	0.32%	–
AUTL	New	AUTOLUS THERAPEUTICS PLCspon ads	$7,694,000	–	479,988	–	0.29%	–
AVEO	New	AVEO PHARMACEUTICALS INC	$6,953,000	–	1,350,000	–	0.26%	–
BCEL	New	ATRECA INC	$6,838,000	–	321,322	–	0.26%	–
BNR	New	BURNING ROCK BIOTECH LTDsponsored ads	$6,753,000	–	250,000	–	0.26%	–
KZR	New	KEZAR LIFE SCIENCES INC	$6,734,000	–	1,300,000	–	0.26%	–
EIGR	New	EIGER BIOPHARMACEUTICALS INC	$6,720,000	–	700,000	–	0.26%	–
GTH	New	GENETRON HLDGS LTDads	$6,035,000	–	500,000	–	0.23%	–
AVRO	New	AVROBIO INC	$5,542,000	–	317,579	–	0.21%	–
ARNA	New	ARENA PHARMACEUTICALS INC	$4,721,000	–	75,000	–	0.18%	–
ARYBU	New	ARYA SCIENCES ACQUISITION COunit 06/09/2027	$4,640,000	–	400,000	–	0.18%	–
GOSS	New	GOSSAMER BIO INC	$4,541,000	–	349,325	–	0.17%	–
AMRN	New	AMARIN CORP PLCspons adr new	$4,152,000	–	600,000	–	0.16%	–
NKTR	New	NEKTAR THERAPEUTICS	$2,895,000	–	125,000	–	0.11%	–
DTIL	New	PRECISION BIOSCIENCES INC	$2,887,000	–	346,524	–	0.11%	–
TBPH	New	THERAVANCE BIOPHARMA INC	$2,099,000	–	100,000	–	0.08%	–
NERV	New	MINERVA NEUROSCIENCES INC	$1,849,000	–	512,159	–	0.07%	–
XFOR	New	X4 PHARMACEUTICALS INC -CW24	$1,757,000	–	328,980	–	0.07%	–
FATE	New	FATE THERAPEUTICS INC	$1,716,000	–	50,000	–	0.06%	–
ORTX	New	ORCHARD THERAPEUTICS PLCads	$1,540,000	–	256,649	–	0.06%	–
OTLKW	New	OUTLOOK THERAPEUTICS INC*w exp 02/18/202	$117,000	–	416,666	–	0.00%	–

Q4 2019

			Value		Shares		↓ Weighting
OTLK	Exit	OUTLOOK THERAPEUTICS INC	$0	–	-15,753	–	-0.00%	–
OTLKW	Exit	OUTLOOK THERAPEUTICS INC*w exp 02/18/202	$0	–	-416,666	–	-0.00%	–
ACRS	Exit	ACLARIS THERAPEUTICS INC	$0	–	-250,000	–	-0.02%	–
ABEO	Exit	ABEONA THERAPEUTICS INC	$0	–	-200,000	–	-0.03%	–
IFRX	Exit	INFLARX NV	$0	–	-300,000	–	-0.04%	–
XLRN	Exit	ACCELERON PHARMA INC	$0	–	-25,000	–	-0.06%	–
GTHX	Exit	G1 THERAPEUTICS INC	$0	–	-1,000	–	-0.06%	–
SRRK	Exit	SCHOLAR ROCK HLDG CORP	$0	–	-118,950	–	-0.06%	–
BOLD	Exit	AUDENTES THERAPEUTICS INC	$0	–	-50,000	–	-0.09%	–
ADVM	Exit	ADVERUM BIOTECHNOLOGIES INCcall	$0	–	-300,000	–	-0.10%	–
ITRM	Exit	ITERUM THERAPEUTICS PLC	$0	–	-396,385	–	-0.14%	–
IGMS	Exit	IGM BIOSCIENCES INC	$0	–	-156,400	–	-0.17%	–
KZR	Exit	KEZAR LIFE SCIENCES INC	$0	–	-927,869	–	-0.18%	–
PHAS	Exit	PHASEBIO PHARMACEUTICALS INC	$0	–	-816,448	–	-0.21%	–
NBIX	Exit	NEUROCRINE BIOSCIENCES INC	$0	–	-39,300	–	-0.22%	–
RUBY	Exit	RUBIUS THERAPEUTICS INC	$0	–	-491,700	–	-0.24%	–
DTIL	Exit	PRECISION BIOSCIENCES INC	$0	–	-467,518	–	-0.24%	–
ATRA	Exit	ATARA BIOTHERAPEUTICS INC	$0	–	-300,000	–	-0.26%	–
FIXX	Exit	HOMOLOGY MEDICINES INC	$0	–	-245,100	–	-0.27%	–
NERV	Exit	MINERVA NEUROSCIENCES INC	$0	–	-607,903	–	-0.29%	–
BCEL	Exit	ATRECA INC	$0	–	-406,142	–	-0.30%	–
GNFT	Exit	GENFIT S Aads	$0	–	-300,000	–	-0.32%	–
AUTL	Exit	AUTOLUS THERAPEUTICS PLCspon ads	$0	–	-479,988	–	-0.36%	–
RARX	Exit	RA PHARMACEUTICALS INC	$0	–	-295,600	–	-0.43%	–
CNST	Exit	CONSTELLATION PHARMACEUTICAL I	$0	–	-1,213,274	–	-0.48%	–
ARNA	Exit	ARENA PHARMACEUTICALS INC	$0	–	-172,300	–	-0.48%	–
AVRO	Exit	AVROBIO INC	$0	–	-568,294	–	-0.49%	–
ORTX	Exit	ORCHARD THERAPEUTICS PLCads	$0	–	-675,325	–	-0.49%	–
HARP	Exit	HARPOON THERAPEUTICS INC	$0	–	-649,994	–	-0.54%	–
ZLAB	Exit	ZAI LAB LTDadr	$0	–	-277,161	–	-0.55%	–
EIGR	Exit	EIGER BIOPHARMACEUTICALS INC	$0	–	-997,892	–	-0.62%	–
GOSS	Exit	GOSSAMER BIO INC	$0	–	-618,129	–	-0.63%	–
INSP	Exit	INSPIRE MED SYS INC	$0	–	-172,300	–	-0.64%	–
XFOR	Exit	X4 PHARMACEUTICALS INC	$0	–	-881,681	–	-0.68%	–
HSACU	Exit	HEALTH SCIENCES ACQUISITN CORPunit 04/01/2024	$0	–	-1,080,000	–	-0.70%	–
CCXI	Exit	CHEMOCENTRYX INC	$0	–	-1,820,000	–	-0.75%	–
SAGE	Exit	SAGE THERAPEUTICS INC	$0	–	-88,700	–	-0.76%	–
STSA	Exit	SATSUMA PHARMACEUTICALS INC	$0	–	-858,382	–	-0.78%	–
NKTR	Exit	NEKTAR THERAPEUTICS	$0	–	-788,800	–	-0.88%	–
ARGX	Exit	ARGENX SEsponsored adr	$0	–	-128,110	–	-0.89%	–
MRTX	Exit	MIRATI THERAPEUTICS INCcall	$0	–	-200,000	–	-0.95%	–
TWST	Exit	TWIST BIOSCIENCE CORP	$0	–	-687,149	–	-1.00%	–
SRPT	Exit	SAREPTA THERAPEUTICS INC	$0	–	-221,700	–	-1.02%	–
AKRO	Exit	AKERO THERAPEUTICS INC	$0	–	-740,621	–	-1.03%	–
KURA	Exit	KURA ONCOLOGY INC	$0	–	-1,231,500	–	-1.14%	–
EIDX	Exit	EIDOS THERAPEUTICS INC	$0	–	-540,686	–	-1.18%	–
AMRN	Exit	AMARIN CORP PLCspons adr new	$0	–	-1,332,000	–	-1.23%	–
ANAB	Exit	ANAPTYSBIO INC	$0	–	-591,200	–	-1.26%	–
GLPG	Exit	GALAPAGOS NVspon adr	$0	–	-150,000	–	-1.39%	–
YMAB	Exit	Y-MABS THERAPEUTICS INC	$0	–	-883,800	–	-1.40%	–
MYOK	Exit	MYOKARDIA INC	$0	–	-443,000	–	-1.41%	–
ASND	Exit	ASCENDIS PHARMA A Scall	$0	–	-250,000	–	-1.47%	–
RCKT	Exit	ROCKET PHARMACEUTICALS INC	$0	–	-2,123,760	–	-1.51%	–
BHVN	Exit	BIOHAVEN PHARMACTL HLDG CO Lcall	$0	–	-600,000	–	-1.52%	–
DCPH	Exit	DECIPHERA PHARMACEUTICALS IN	$0	–	-788,500	–	-1.63%	–
NXTC	Exit	NEXTCURE INC	$0	–	-884,600	–	-1.66%	–
QTNT	Exit	QUOTIENT LTD	$0	–	-3,642,000	–	-1.72%	–
XBI	Exit	SPDR SERIES TRUSTput	$0	–	-400,000	–	-1.86%	–
AXNX	Exit	AXONICS MODULATION TECH INC	$0	–	-1,222,671	–	-2.00%	–
TCDA	Exit	TRICIDA INC	$0	–	-1,082,880	–	-2.04%	–
ALLK	Exit	ALLAKOS INC	$0	–	-444,100	–	-2.13%	–
QURE	Exit	UNIQURE NV	$0	–	-900,000	–	-2.16%	–
BPMC	Exit	BLUEPRINT MEDICINES CORP	$0	–	-493,000	–	-2.20%	–
PRNB	Exit	PRINCIPIA BIOPHARMA INC	$0	–	-1,341,896	–	-2.31%	–
STOK	Exit	STOKE THERAPEUTICS INC	$0	–	-1,788,394	–	-2.34%	–
MRTX	Exit	MIRATI THERAPEUTICS INCput	$0	–	-550,000	–	-2.61%	–
CRSP	Exit	CRISPR THERAPEUTICS AGnamen akt	$0	–	-1,084,300	–	-2.70%	–
ASND	Exit	ASCENDIS PHARMA A Ssponsored adr	$0	–	-468,300	–	-2.75%	–
BHVN	Exit	BIOHAVEN PHARMACTL HLDG CO L	$0	–	-1,281,400	–	-3.25%	–
BBIO	Exit	BRIDGEBIO PHARMA INC	$0	–	-2,617,566	–	-3.42%	–
RETA	Exit	REATA PHARMACEUTICALS INCcl a	$0	–	-819,769	–	-4.01%	–
APLS	Exit	APELLIS PHARMACEUTICALS INC	$0	–	-2,976,000	–	-4.36%	–
SPY	Exit	SPDR S&P 500 ETF TRput	$0	–	-400,000	–	-7.23%	–
MRTX	Exit	MIRATI THERAPEUTICS INC	$0	–	-1,600,000	–	-7.59%	–
TPTX	Exit	TURNING POINT THERAPEUTICS I	$0	–	-3,541,367	–	-8.10%	–

Q3 2019

			Value		Shares		↓ Weighting
TPTX	Buy	TURNING POINT THERAPEUTICS I	$133,155,000	+4.8%	3,541,367	+13.4%	8.10%	+11.0%
MRTX	Buy	MIRATI THERAPEUTICS INC	$124,656,000	+10.0%	1,600,000	+45.5%	7.59%	+16.6%
SPY	New	SPDR S&P 500 ETF TRput	$118,708,000	–	400,000	–	7.23%	–
APLS	Buy	APELLIS PHARMACEUTICALS INC	$71,692,000	-4.6%	2,976,000	+0.3%	4.36%	+1.1%
RETA	Buy	REATA PHARMACEUTICALS INCcl a	$65,819,000	-13.5%	819,769	+1.7%	4.01%	-8.3%
BBIO	Sell	BRIDGEBIO PHARMA INC	$56,199,000	-25.1%	2,617,566	-5.9%	3.42%	-20.6%
BHVN	Sell	BIOHAVEN PHARMACTL HLDG CO L	$53,460,000	-21.2%	1,281,400	-17.3%	3.25%	-16.5%
ASND	Buy	ASCENDIS PHARMA A Ssponsored adr	$45,107,000	-2.1%	468,300	+17.1%	2.75%	+3.8%
CRSP	Buy	CRISPR THERAPEUTICS AGnamen akt	$44,445,000	+34.8%	1,084,300	+54.9%	2.70%	+42.8%
MRTX	New	MIRATI THERAPEUTICS INCput	$42,851,000	–	550,000	–	2.61%	–
STOK	Sell	STOKE THERAPEUTICS INC	$38,433,000	-29.5%	1,788,394	-4.3%	2.34%	-25.3%
PRNB	Sell	PRINCIPIA BIOPHARMA INC	$37,895,000	-16.2%	1,341,896	-1.5%	2.31%	-11.1%
BPMC	Buy	BLUEPRINT MEDICINES CORP	$36,221,000	+9.7%	493,000	+40.9%	2.20%	+16.3%
QURE	Buy	UNIQURE NV	$35,424,000	-24.5%	900,000	+50.0%	2.16%	-19.9%
ALLK	Sell	ALLAKOS INC	$34,920,000	+24.0%	444,100	-31.7%	2.13%	+31.4%
TCDA	Sell	TRICIDA INC	$33,429,000	-28.1%	1,082,880	-8.1%	2.04%	-23.8%
AXNX	Sell	AXONICS MODULATION TECH INC	$32,914,000	-35.9%	1,222,671	-2.4%	2.00%	-32.0%
XBI	Sell	SPDR SERIES TRUSTput	$30,500,000	-61.4%	400,000	-55.6%	1.86%	-59.0%
QTNT	Sell	QUOTIENT LTD	$28,298,000	-20.4%	3,642,000	-4.2%	1.72%	-15.6%
NXTC	Sell	NEXTCURE INC	$27,290,000	+82.2%	884,600	-11.5%	1.66%	+93.1%
DCPH	New	DECIPHERA PHARMACEUTICALS IN	$26,762,000	–	788,500	–	1.63%	–
BHVN	Buy	BIOHAVEN PHARMACTL HLDG CO Lcall	$25,032,000	+3.9%	600,000	+9.1%	1.52%	+10.2%
RCKT	Buy	ROCKET PHARMACEUTICALS INC	$24,742,000	-20.5%	2,123,760	+2.4%	1.51%	-15.7%
MYOK	Sell	MYOKARDIA INC	$23,102,000	-7.9%	443,000	-11.4%	1.41%	-2.4%
YMAB	Sell	Y-MABS THERAPEUTICS INC	$23,032,000	+0.7%	883,800	-11.6%	1.40%	+6.7%
GLPG	Sell	GALAPAGOS NVspon adr	$22,854,000	+1.2%	150,000	-14.3%	1.39%	+7.2%
ANAB	Sell	ANAPTYSBIO INC	$20,686,000	-47.6%	591,200	-15.5%	1.26%	-44.5%
AMRN	Buy	AMARIN CORP PLCspons adr new	$20,193,000	+108.3%	1,332,000	+166.4%	1.23%	+120.6%
EIDX	Sell	EIDOS THERAPEUTICS INC	$19,448,000	+13.4%	540,686	-2.0%	1.18%	+20.2%
KURA	Sell	KURA ONCOLOGY INC	$18,682,000	-32.2%	1,231,500	-12.0%	1.14%	-28.2%
AKRO	Sell	AKERO THERAPEUTICS INC	$16,849,000	+14.6%	740,621	-3.5%	1.03%	+21.4%
SRPT	Sell	SAREPTA THERAPEUTICS INC	$16,698,000	-51.2%	221,700	-1.5%	1.02%	-48.3%
TWST	Sell	TWIST BIOSCIENCE CORP	$16,409,000	-19.9%	687,149	-2.7%	1.00%	-15.1%
ARGX	Sell	ARGENX SEsponsored adr	$14,599,000	-31.3%	128,110	-14.6%	0.89%	-27.1%
NKTR	Buy	NEKTAR THERAPEUTICS	$14,368,000	+1.0%	788,800	+97.2%	0.88%	+7.1%
STSA	New	SATSUMA PHARMACEUTICALS INC	$12,884,000	–	858,382	–	0.78%	–
SAGE	Sell	SAGE THERAPEUTICS INC	$12,444,000	-32.0%	88,700	-11.3%	0.76%	-28.0%
CCXI	Sell	CHEMOCENTRYX INC	$12,340,000	-43.9%	1,820,000	-23.1%	0.75%	-40.5%
XFOR	Sell	X4 PHARMACEUTICALS INC	$11,206,000	-16.1%	881,681	-1.0%	0.68%	-11.1%
INSP	Sell	INSPIRE MED SYS INC	$10,514,000	-13.3%	172,300	-13.8%	0.64%	-8.2%
GOSS	Sell	GOSSAMER BIO INC	$10,378,000	-27.2%	618,129	-3.9%	0.63%	-22.8%
EIGR	Sell	EIGER BIOPHARMACEUTICALS INC	$10,228,000	-16.1%	997,892	-13.2%	0.62%	-11.0%
ZLAB	Sell	ZAI LAB LTDadr	$8,966,000	-14.3%	277,161	-7.6%	0.55%	-9.2%
ORTX	Sell	ORCHARD THERAPEUTICS PLCads	$8,023,000	-21.5%	675,325	-7.5%	0.49%	-16.9%
AVRO	Buy	AVROBIO INC	$8,024,000	+79.4%	568,294	+106.7%	0.49%	+89.9%
ARNA	Sell	ARENA PHARMACEUTICALS INC	$7,886,000	-32.7%	172,300	-13.8%	0.48%	-28.8%
CNST	Sell	CONSTELLATION PHARMACEUTICAL I	$7,838,000	-49.8%	1,213,274	-4.6%	0.48%	-46.8%
RARX	Sell	RA PHARMACEUTICALS INC	$6,991,000	-33.6%	295,600	-15.5%	0.43%	-29.6%
AUTL	Sell	AUTOLUS THERAPEUTICS PLCspon ads	$5,961,000	-47.1%	479,988	-31.4%	0.36%	-43.9%
GNFT	Sell	GENFIT S Aads	$5,223,000	-17.3%	300,000	-6.2%	0.32%	-12.4%
BCEL	Sell	ATRECA INC	$4,971,000	-40.7%	406,142	-8.7%	0.30%	-37.1%
FIXX	Sell	HOMOLOGY MEDICINES INC	$4,436,000	-24.4%	245,100	-18.3%	0.27%	-19.9%
ATRA	Sell	ATARA BIOTHERAPEUTICS INC	$4,236,000	-47.3%	300,000	-25.0%	0.26%	-44.2%
RUBY	Sell	RUBIUS THERAPEUTICS INC	$3,860,000	-59.1%	491,700	-18.0%	0.24%	-56.6%
NBIX	Sell	NEUROCRINE BIOSCIENCES INC	$3,541,000	-16.1%	39,300	-21.4%	0.22%	-11.1%
PHAS	Sell	PHASEBIO PHARMACEUTICALS INC	$3,405,000	-71.4%	816,448	-9.9%	0.21%	-69.7%
KZR	Sell	KEZAR LIFE SCIENCES INC	$3,043,000	-59.2%	927,869	-4.2%	0.18%	-56.9%
IGMS	New	IGM BIOSCIENCES INC	$2,776,000	–	156,400	–	0.17%	–
ADVM	New	ADVERUM BIOTECHNOLOGIES INCcall	$1,635,000	–	300,000	–	0.10%	–
BOLD	Sell	AUDENTES THERAPEUTICS INC	$1,405,000	-50.5%	50,000	-33.3%	0.09%	-47.2%
SRRK	Sell	SCHOLAR ROCK HLDG CORP	$1,065,000	-55.2%	118,950	-20.7%	0.06%	-52.6%
GTHX	New	G1 THERAPEUTICS INC	$1,025,000	–	1,000	–	0.06%	–
XLRN	Sell	ACCELERON PHARMA INC	$988,000	-39.9%	25,000	-37.5%	0.06%	-36.2%
IFRX	Sell	INFLARX NV	$741,000	-84.4%	300,000	-80.0%	0.04%	-83.5%
ABEO	Sell	ABEONA THERAPEUTICS INC	$452,000	-73.0%	200,000	-42.9%	0.03%	-70.8%
OTLK	Buy	OUTLOOK THERAPEUTICS INC	$23,000	-28.1%	15,753	+0.0%	0.00%	-50.0%
CLRBW	Exit	CELLECTAR BIOSCIENCES INC*w exp 08/20/201	$0	–	-52,999	–	0.00%	–
QURE	Exit	UNIQURE NVcall	$0	–	-100,000	–	-0.45%	–
VRTX	Exit	VERTEX PHARMACEUTICALS INC	$0	–	-85,000	–	-0.90%	–
ARRY	Exit	ARRAY BIOPHARMA INC	$0	–	-450,000	–	-1.20%	–

Q2 2019

			Value		Shares		↓ Weighting
TPTX	New	TURNING POINT THERAPEUTICS I	$127,080,000	–	3,122,367	–	7.30%	–
MRTX	New	MIRATI THERAPEUTICS INC	$113,300,000	–	1,100,000	–	6.51%	–
XBI	New	SPDR SERIES TRUSTput	$78,939,000	–	900,000	–	4.53%	–
RETA	New	REATA PHARMACEUTICALS INCcl a	$76,060,000	–	806,150	–	4.37%	–
APLS	New	APELLIS PHARMACEUTICALS INC	$75,161,000	–	2,966,108	–	4.32%	–
BBIO	New	BRIDGEBIO PHARMA INC	$75,000,000	–	2,780,885	–	4.31%	–
BHVN	New	BIOHAVEN PHARMACTL HLDG CO L	$67,875,000	–	1,550,000	–	3.90%	–
STOK	New	STOKE THERAPEUTICS INC	$54,539,000	–	1,869,680	–	3.13%	–
AXNX	New	AXONICS MODULATION TECH INC	$51,315,000	–	1,252,495	–	2.95%	–
QURE	New	UNIQURE NV	$46,890,000	–	600,000	–	2.69%	–
TCDA	New	TRICIDA INC	$46,483,000	–	1,177,975	–	2.67%	–
ASND	New	ASCENDIS PHARMA A Ssponsored adr	$46,060,000	–	400,000	–	2.65%	–
PRNB	New	PRINCIPIA BIOPHARMA INC	$45,201,000	–	1,361,898	–	2.60%	–
ANAB	New	ANAPTYSBIO INC	$39,494,000	–	700,000	–	2.27%	–
QTNT	New	QUOTIENT LTD	$35,530,000	–	3,800,000	–	2.04%	–
SRPT	New	SAREPTA THERAPEUTICS INC	$34,189,000	–	225,000	–	1.96%	–
BPMC	New	BLUEPRINT MEDICINES CORP	$33,016,000	–	350,000	–	1.90%	–
CRSP	New	CRISPR THERAPEUTICS AGnamen akt	$32,970,000	–	700,000	–	1.89%	–
RCKT	New	ROCKET PHARMACEUTICALS INC	$31,119,000	–	2,074,595	–	1.79%	–
ASND	New	ASCENDIS PHARMA A Scall	$28,788,000	–	250,000	–	1.65%	–
ALLK	New	ALLAKOS INC	$28,165,000	–	650,000	–	1.62%	–
KURA	New	KURA ONCOLOGY INC	$27,566,000	–	1,400,000	–	1.58%	–
MYOK	New	MYOKARDIA INC	$25,070,000	–	500,000	–	1.44%	–
BHVN	New	BIOHAVEN PHARMACTL HLDG CO Lcall	$24,085,000	–	550,000	–	1.38%	–
YMAB	New	Y-MABS THERAPEUTICS INC	$22,870,000	–	1,000,000	–	1.31%	–
GLPG	New	GALAPAGOS NVspon adr	$22,576,000	–	175,000	–	1.30%	–
CCXI	New	CHEMOCENTRYX INC	$21,997,000	–	2,365,280	–	1.26%	–
ARGX	New	ARGENX SEsponsored adr	$21,237,000	–	150,000	–	1.22%	–
ARRY	New	ARRAY BIOPHARMA INC	$20,849,000	–	450,000	–	1.20%	–
MRTX	New	MIRATI THERAPEUTICS INCcall	$20,600,000	–	200,000	–	1.18%	–
TWST	New	TWIST BIOSCIENCE CORP	$20,483,000	–	706,064	–	1.18%	–
SAGE	New	SAGE THERAPEUTICS INC	$18,309,000	–	100,000	–	1.05%	–
EIDX	New	EIDOS THERAPEUTICS INC	$17,154,000	–	551,921	–	0.98%	–
CNST	New	CONSTELLATION PHARMCETICLS I	$15,616,000	–	1,271,685	–	0.90%	–
VRTX	New	VERTEX PHARMACEUTICALS INC	$15,587,000	–	85,000	–	0.90%	–
NXTC	New	NEXTCURE INC	$14,980,000	–	1,000,000	–	0.86%	–
AKRO	New	AKERO THERAPEUTICS INC	$14,704,000	–	767,842	–	0.84%	–
GOSS	New	GOSSAMER BIO INC	$14,265,000	–	643,129	–	0.82%	–
NKTR	New	NEKTAR THERAPEUTICS	$14,232,000	–	400,000	–	0.82%	–
XFOR	New	X4 PHARMACEUTICALS INC	$13,356,000	–	890,387	–	0.77%	–
EIGR	New	EIGER BIOPHARMACEUTICALS INC	$12,190,000	–	1,150,000	–	0.70%	–
INSP	New	INSPIRE MED SYS INC	$12,130,000	–	200,000	–	0.70%	–
PHAS	New	PHASEBIO PHARMACEUTICALS INC	$11,890,000	–	906,229	–	0.68%	–
ARNA	New	ARENA PHARMACEUTICALS INC	$11,726,000	–	200,000	–	0.67%	–
HSACU	New	HEALTH SCIENCES ACQUSTN CORPunit 04/01/2024	$11,450,000	–	1,080,000	–	0.66%	–
AUTL	New	AUTOLUS THERAPEUTICS PLCspon ads	$11,270,000	–	700,000	–	0.65%	–
RARX	New	RA PHARMACEUTICALS INC	$10,525,000	–	350,000	–	0.60%	–
ZLAB	New	ZAI LAB LTDadr	$10,461,000	–	300,000	–	0.60%	–
ORTX	New	ORCHARD THERAPEUTICS PLCads	$10,217,000	–	730,325	–	0.59%	–
AMRN	New	AMARIN CORP PLCspons adr new	$9,695,000	–	500,000	–	0.56%	–
RUBY	New	RUBIUS THERAPEUTICS INC	$9,438,000	–	600,000	–	0.54%	–
HARP	New	HARPOON THERAPEUTICS INC	$8,450,000	–	649,994	–	0.48%	–
BCEL	New	ATRECA INC	$8,383,000	–	444,942	–	0.48%	–
ATRA	New	ATARA BIOTHERAPEUTICS INC	$8,044,000	–	400,000	–	0.46%	–
QURE	New	UNIQURE NVcall	$7,815,000	–	100,000	–	0.45%	–
KZR	New	KEZAR LIFE SCIENCES INC	$7,466,000	–	968,294	–	0.43%	–
GNFT	New	GENFIT S Aads	$6,314,000	–	319,700	–	0.36%	–
DTIL	New	PRECISION BIOSCIENCES, INC - SERIES B PREFERRED	$6,195,000	–	467,518	–	0.36%	–
FIXX	New	HOMOLOGY MEDICINES INC	$5,871,000	–	300,000	–	0.34%	–
IFRX	New	INFLARX NV	$4,740,000	–	1,500,000	–	0.27%	–
AVRO	New	AVROBIO INC	$4,472,000	–	275,000	–	0.26%	–
NBIX	New	NEUROCRINE BIOSCIENCES INC	$4,222,000	–	50,000	–	0.24%	–
NERV	New	MINERVA NEUROSCIENCES INC	$3,422,000	–	607,903	–	0.20%	–
BOLD	New	AUDENTES THERAPEUTICS INC	$2,840,000	–	75,000	–	0.16%	–
ITRM	New	ITERUM THERAPEUTICS PLC	$2,727,000	–	396,385	–	0.16%	–
SRRK	New	SCHOLAR ROCK HLDG CORP	$2,379,000	–	150,000	–	0.14%	–
ABEO	New	ABEONA THERAPEUTICS INC	$1,673,000	–	350,000	–	0.10%	–
XLRN	New	ACCELERON PHARMA INC	$1,643,000	–	40,000	–	0.09%	–
ACRS	New	ACLARIS THERAPEUTICS INC	$548,000	–	250,000	–	0.03%	–
OTLKW	New	OUTLOOK THERAPEUTICS INC*w exp 02/18/202	$46,000	–	416,666	–	0.00%	–
OTLK	New	OUTLOOK THERAPEUTICS INC	$32,000	–	15,752	–	0.00%	–
CLRBW	New	CELLECTAR BIOSCIENCES INC*w exp 08/20/201	$3,000	–	52,999	–	0.00%	–

Q4 2018

			Value		Shares		↓ Weighting
CLRBW	Exit	CELLECTAR BIOSCIENCES-CW19*w exp 08/20/201	$0	–	-52,999	–	0.00%	–
ONSIW	Exit	ONCOBIOLOGICS INC - CW17 -A*w exp 02/18/201	$0	–	-416,666	–	-0.00%	–
QTRX	Exit	QUANTERIX CORP	$0	–	-54,945	–	-0.08%	–
ARQL	Exit	ARQULE INC	$0	–	-300,000	–	-0.11%	–
CLSD	Exit	CLEARSIDE BIOMEDICAL INC	$0	–	-400,000	–	-0.16%	–
XLRN	Exit	ACCELERON PHARMA INC	$0	–	-50,000	–	-0.19%	–
	Exit	TRILLIUM THERAPEUTICS INC	$0	–	-500,000	–	-0.19%	–
MRNS	Exit	MARINUS PHARMACEUTICALS INC	$0	–	-300,000	–	-0.20%	–
ITRM	Exit	ITERUM THERAPEUTICS PLC	$0	–	-476,968	–	-0.21%	–
MGTX	Exit	MEIRAGTX HOLDINGS PLC	$0	–	-238,579	–	-0.21%	–
SGMO	Exit	SANGAMO BIOSCIENCES INC	$0	–	-200,000	–	-0.22%	–
AKCA	Exit	AKCEA THERAPEUTICS INCput	$0	–	-100,000	–	-0.23%	–
COLL	Exit	COLLEGIUM PHARMACEUTICAL INC	$0	–	-250,000	–	-0.24%	–
EIDX	Exit	EIDOS THERAPEUTICS INC	$0	–	-385,846	–	-0.25%	–
TBIO	Exit	TRANSLATE BIO, INC	$0	–	-454,550	–	-0.30%	–
BOLD	Exit	AUDENTES THERAPEUTICS INC	$0	–	-125,000	–	-0.32%	–
YMAB	Exit	Y MABS THERAPEUTICS INC	$0	–	-200,000	–	-0.34%	–
HRTX	Exit	HERON THERAPEUTICS INC	$0	–	-170,000	–	-0.35%	–
SRRK	Exit	SCHOLAR ROCK HLDG CORP	$0	–	-210,078	–	-0.35%	–
CFRX	Exit	CONTRAFECT CORP	$0	–	-3,000,000	–	-0.40%	–
ABEO	Exit	ABEONA THERAPEUTICS INC	$0	–	-500,000	–	-0.42%	–
ACRS	Exit	ACLARIS THERAPEUTICS INC	$0	–	-500,000	–	-0.47%	–
REPL	Exit	REPLIMUNE GROUP INC	$0	–	-467,792	–	-0.49%	–
NERV	Exit	MINERVA NEUROSCIENCES INC	$0	–	-607,903	–	-0.50%	–
AMRN	Exit	AMARIN CORP PLCspons adr new	$0	–	-500,000	–	-0.53%	–
SPPI	Exit	SPECTRUM PHARMACEUTICALS INC	$0	–	-500,000	–	-0.55%	–
CNST	Exit	CONSTELLATION PHARMCETICLS I	$0	–	-1,271,687	–	-0.56%	–
RUBY	Exit	RUBIUS THERAPEUTICS INC	$0	–	-364,559	–	-0.57%	–
ARRY	Exit	ARRAY BIOPHARMA INC	$0	–	-600,000	–	-0.59%	–
BHVN	Exit	BIOHAVEN PHARMACTL HLDG CO L	$0	–	-260,000	–	-0.64%	–
ZGNX	Exit	ZOGENIX INCcall	$0	–	-250,000	–	-0.81%	–
INSP	Exit	INSPIRE MED SYS INC	$0	–	-300,000	–	-0.82%	–
ARGX	Exit	ARGEN SEsponsored adr	$0	–	-190,000	–	-0.94%	–
ZLAB	Exit	ZAI LAB LTDadr	$0	–	-808,166	–	-1.02%	–
INCY	Exit	INCYTE CORP	$0	–	-260,000	–	-1.17%	–
ARNA	Exit	ARENA PHARMACEUTICALS INC	$0	–	-410,000	–	-1.23%	–
TSRO	Exit	TESARO INCcall	$0	–	-500,000	–	-1.27%	–
KNSA	Exit	KINIKSA PHARMACEUTICALS LTD	$0	–	-831,000	–	-1.38%	–
NBIX	Exit	NEUROCRINE BIOSCIENCES INC	$0	–	-175,000	–	-1.40%	–
TCDA	Exit	TRICIDA INC	$0	–	-734,588	–	-1.46%	–
OMER	Exit	OMEROS CORP	$0	–	-1,000,000	–	-1.59%	–
ZGNX	Exit	ZOGENIX INC	$0	–	-500,000	–	-1.61%	–
ASND	Exit	ASCENDIS PHARMA A Ssponsored adr	$0	–	-350,000	–	-1.61%	–
SAGE	Exit	SAGE THERAPEUTICS INC	$0	–	-190,000	–	-1.74%	–
OMER	Exit	OMEROS CORPcall	$0	–	-1,136,900	–	-1.80%	–
BPMC	Exit	BLUEPRINT MEDICINES CORP	$0	–	-380,000	–	-1.93%	–
SLDB	Exit	SOLID BIOSCIENCES INC	$0	–	-670,513	–	-2.06%	–
KZR	Exit	KEZAR LIFE SCIENCES INC	$0	–	-1,552,911	–	-2.16%	–
GTHX	Exit	G1 THERAPEUTICS INC	$0	–	-640,481	–	-2.18%	–
TBPH	Exit	THERAVANCE BIOPHARMA INC	$0	–	-1,100,000	–	-2.34%	–
QTNT	Exit	QUOTIENT LTD	$0	–	-4,850,000	–	-2.38%	–
RCKT	Exit	ROCKET PHARMACEUTICALS INC	$0	–	-1,500,659	–	-2.40%	–
AUTL	Exit	AUTOLUS THERAPEUTICS PLCspon ads	$0	–	-1,326,136	–	-2.64%	–
PRNB	Exit	PRINCIPIA BIOPHARMA INC	$0	–	-1,486,898	–	-2.82%	–
MYOK	Exit	MYOKARDIA INC	$0	–	-700,000	–	-2.97%	–
IFRX	Exit	INFLARX NV	$0	–	-1,341,540	–	-2.99%	–
TSRO	Exit	TESARO INC	$0	–	-1,250,000	–	-3.17%	–
RETA	Exit	REATA PHARMACEUTICALS INCcl a	$0	–	-660,000	–	-3.51%	–
DRNA	Exit	DICERNA PHARMACEUTICALS INC	$0	–	-3,556,669	–	-3.53%	–
APLS	Exit	APELLIS PHARMACEUTICALS INC	$0	–	-4,172,498	–	-4.82%	–
AVRO	Exit	AVROBIO INC	$0	–	-1,492,784	–	-5.03%	–
NKTR	Exit	NEKTAR THERAPEUTICScall	$0	–	-1,328,400	–	-5.26%	–
NKTR	Exit	NEKTAR THERAPEUTICS	$0	–	-1,370,000	–	-5.43%	–
MRTX	Exit	MIRATI THERAPEUTICS INC	$0	–	-1,810,000	–	-5.54%	–
ANAB	Exit	ANAPTYSBIO INC	$0	–	-1,135,000	–	-7.36%	–

Q3 2018

			Value		Shares		↓ Weighting
ANAB	Sell	ANAPTYSBIO INC	$113,239,000	+29.2%	1,135,000	-8.0%	7.36%	+13.5%
MRTX	Sell	MIRATI THERAPEUTICS INC	$85,251,000	-9.9%	1,810,000	-5.6%	5.54%	-20.8%
NKTR	Sell	NEKTAR THERAPEUTICS	$83,515,000	+14.0%	1,370,000	-8.7%	5.43%	+0.1%
NKTR	Sell	NEKTAR THERAPEUTICScall	$80,979,000	-9.3%	1,328,400	-27.3%	5.26%	-20.3%
AVRO	Sell	AVROBIO INC	$77,431,000	+79.8%	1,492,784	-1.0%	5.03%	+57.9%
APLS	Sell	APELLIS PHARMACEUTICALS INC	$74,187,000	-21.8%	4,172,498	-3.2%	4.82%	-31.3%
DRNA	Sell	DICERNA PHARMACEUTICALS INC	$54,275,000	+23.0%	3,556,669	-1.2%	3.53%	+8.1%
RETA	Buy	REATA PHARMACEUTICALS INCcl a	$53,962,000	+242.9%	660,000	+46.7%	3.51%	+201.0%
TSRO	Buy	TESARO INC	$48,763,000	+99.4%	1,250,000	+127.3%	3.17%	+75.1%
IFRX	Sell	INFLARX NV	$46,042,000	-4.0%	1,341,540	-9.8%	2.99%	-15.7%
MYOK	Sell	MYOKARDIA INC	$45,640,000	+20.1%	700,000	-8.8%	2.97%	+5.4%
PRNB	New	PRINCIPIA BIOPHARMA INC	$43,447,000	–	1,486,898	–	2.82%	–
AUTL	Sell	AUTOLUS THERAPEUTICS PLCspon ads	$40,673,000	-0.5%	1,326,136	-13.1%	2.64%	-12.6%
RCKT	Sell	ROCKET PHARMACEUTICALS INC	$36,946,000	+23.8%	1,500,659	-1.3%	2.40%	+8.7%
QTNT	Buy	QUOTIENT LTD	$36,618,000	+6.3%	4,850,000	+13.0%	2.38%	-6.7%
TBPH	Sell	THERAVANCE BIOPHARMA INC	$35,937,000	+21.9%	1,100,000	-15.4%	2.34%	+7.1%
GTHX	Sell	G1 THERAPEUTICS INC	$33,491,000	+7.0%	640,481	-11.0%	2.18%	-6.0%
KZR	Sell	KEZAR LIFE SCIENCES INC	$33,248,000	+22.2%	1,552,911	-1.3%	2.16%	+7.3%
SLDB	Sell	SOLID BIOSCIENCES INC	$31,635,000	+29.4%	670,513	-2.3%	2.06%	+13.7%
BPMC	Sell	BLUEPRINT MEDICINES CORP	$29,663,000	-15.0%	380,000	-30.9%	1.93%	-25.4%
OMER	New	OMEROS CORPcall	$27,752,000	–	1,136,900	–	1.80%	–
SAGE	Sell	SAGE THERAPEUTICS INC	$26,838,000	-28.4%	190,000	-20.7%	1.74%	-37.2%
ASND	Sell	ASCENDIS PHARMA A Ssponsored adr	$24,801,000	+0.3%	350,000	-5.8%	1.61%	-11.9%
ZGNX	New	ZOGENIX INC	$24,800,000	–	500,000	–	1.61%	–
OMER	Sell	OMEROS CORP	$24,410,000	+2.4%	1,000,000	-23.9%	1.59%	-10.0%
TCDA	Sell	TRICIDA INC	$22,442,000	-19.7%	734,588	-21.4%	1.46%	-29.4%
NBIX	Sell	NEUROCRINE BIOSCIENCES INC	$21,516,000	+14.6%	175,000	-8.4%	1.40%	+0.6%
TSRO	New	TESARO INCcall	$19,505,000	–	500,000	–	1.27%	–
ARNA	Sell	ARENA PHARMACEUTICALS INC	$18,868,000	-3.8%	410,000	-8.9%	1.23%	-15.6%
INCY	Buy	INCYTE CORP	$17,961,000	+34.0%	260,000	+30.0%	1.17%	+17.6%
ZLAB	Buy	ZAI LAB LTDadr	$15,743,000	+103.2%	808,166	+142.6%	1.02%	+78.5%
ARGX	Sell	ARGEN SEsponsored adr	$14,410,000	-37.6%	190,000	-31.8%	0.94%	-45.1%
INSP	Sell	INSPIRE MED SYS INC	$12,624,000	+8.9%	300,000	-7.7%	0.82%	-4.3%
ZGNX	New	ZOGENIX INCcall	$12,400,000	–	250,000	–	0.81%	–
BHVN	Sell	BIOHAVEN PHARMACTL HLDG CO L	$9,763,000	-13.2%	260,000	-8.7%	0.64%	-23.8%
ARRY	Sell	ARRAY BIOPHARMA INC	$9,120,000	-18.7%	600,000	-10.3%	0.59%	-28.6%
RUBY	New	RUBIUS THERAPEUTICS INC	$8,749,000	–	364,559	–	0.57%	–
CNST	New	CONSTELLATION PHARMCETICLS I	$8,558,000	–	1,271,687	–	0.56%	–
SPPI	Sell	SPECTRUM PHARMACEUTICALS INC	$8,400,000	-66.6%	500,000	-58.3%	0.55%	-70.7%
AMRN	New	AMARIN CORP PLCspons adr new	$8,135,000	–	500,000	–	0.53%	–
REPL	New	REPLIMUNE GROUP INC	$7,531,000	–	467,792	–	0.49%	–
ACRS	Sell	ACLARIS THERAPEUTICS INC	$7,260,000	-30.8%	500,000	-4.9%	0.47%	-39.3%
ABEO	Sell	ABEONA THERAPEUTICS INC	$6,400,000	-27.2%	500,000	-9.0%	0.42%	-36.0%
CFRX	Sell	CONTRAFECT CORP	$6,210,000	-17.2%	3,000,000	-11.6%	0.40%	-27.2%
HRTX	Sell	HERON THERAPEUTICS INC	$5,381,000	-27.5%	170,000	-11.0%	0.35%	-36.2%
YMAB	New	Y MABS THERAPEUTICS INC	$5,312,000	–	200,000	–	0.34%	–
BOLD	Sell	AUDENTES THERAPEUTICS INC	$4,949,000	-59.9%	125,000	-61.3%	0.32%	-64.7%
COLL	Sell	COLLEGIUM PHARMACEUTICAL INC	$3,685,000	-46.1%	250,000	-12.8%	0.24%	-52.6%
AKCA	New	AKCEA THERAPEUTICS INCput	$3,502,000	–	100,000	–	0.23%	–
SGMO	Sell	SANGAMO BIOSCIENCES INC	$3,390,000	-37.5%	200,000	-47.7%	0.22%	-45.3%
MGTX	Sell	MEIRAGTX HOLDINGS PLC	$3,245,000	+18.7%	238,579	-0.0%	0.21%	+4.5%
ITRM	Sell	ITERUM THERAPEUTICS PLC	$3,196,000	-41.3%	476,968	-4.6%	0.21%	-48.4%
MRNS	Sell	MARINUS PHARMACEUTICALS INC	$3,000,000	-11.2%	300,000	-37.3%	0.20%	-22.0%
	Sell	TRILLIUM THERAPEUTICS INC	$2,900,000	-15.7%	500,000	-12.8%	0.19%	-26.0%
XLRN	Sell	ACCELERON PHARMA INC	$2,862,000	-17.7%	50,000	-30.2%	0.19%	-27.6%
CLSD	Sell	CLEARSIDE BIOMEDICAL INC	$2,460,000	-80.8%	400,000	-66.7%	0.16%	-83.1%
ARQL	New	ARQULE INC	$1,698,000	–	300,000	–	0.11%	–
QTRX	Sell	QUANTERIX CORP	$1,177,000	-90.3%	54,945	-93.5%	0.08%	-91.5%
PTGX	Exit	PROTAGONIST THERAPEUTICS INC	$0	–	-382,139	–	-0.19%	–
	Exit	INTEC PHARMA LTD JERUSALEM	$0	–	-773,816	–	-0.25%	–
GEMP	Exit	GEMPHIRE THERAPEUTICS INC	$0	–	-1,041,635	–	-0.78%	–
	Exit	OMEROS CORPcall	$0	–	-969,000	–	-1.30%	–
VNDA	Exit	VANDA PHARMACEUTICALS INC	$0	–	-957,821	–	-1.35%	–

Q2 2018

			Value		Shares		↓ Weighting
APLS	New	APELLIS PHARMACEUTICALS INC	$94,875,000	–	4,312,498	–	7.02%	–
MRTX	New	MIRATI THERAPEUTICS INC	$94,575,000	–	1,918,350	–	7.00%	–
NKTR	New	NEKTAR THERAPEUTICScall	$89,281,000	–	1,828,400	–	6.61%	–
ANAB	New	ANAPTYSBIO INC	$87,622,000	–	1,233,422	–	6.48%	–
NKTR	New	NEKTAR THERAPEUTICS	$73,245,000	–	1,500,000	–	5.42%	–
IFRX	New	INFLARX NV	$47,964,000	–	1,487,265	–	3.55%	–
DRNA	New	DICERNA PHARMACEUTICALS INC	$44,112,000	–	3,600,954	–	3.26%	–
AVRO	New	AVROBIO INC	$43,062,000	–	1,507,783	–	3.19%	–
AUTL	New	AUTOLUS THERAPEUTICS PLCspon ads	$40,870,000	–	1,525,587	–	3.02%	–
MYOK	New	MYOKARDIA INC	$38,010,000	–	767,363	–	2.81%	–
SAGE	New	SAGE THERAPEUTICS INC	$37,508,000	–	239,619	–	2.78%	–
BPMC	New	BLUEPRINT MEDICINES CORP	$34,914,000	–	550,000	–	2.58%	–
QTNT	New	QUOTIENT LTD	$34,456,000	–	4,290,852	–	2.55%	–
GTHX	New	G1 THERAPEUTICS INC	$31,291,000	–	719,985	–	2.32%	–
RCKT	New	ROCKET PHARMACEUTICALS, INC	$29,835,000	–	1,519,890	–	2.21%	–
TBPH	New	THERAVANCE BIOPHARMA INC	$29,484,000	–	1,300,000	–	2.18%	–
TCDA	New	TRICIDA INC	$27,944,000	–	934,588	–	2.07%	–
KZR	New	KEZAR LIFE SCIENCES INC	$27,211,000	–	1,572,910	–	2.01%	–
SPPI	New	SPECTRUM PHARMACEUTICALS INC	$25,152,000	–	1,200,000	–	1.86%	–
ASND	New	ASCENDIS PHARMA A Ssponsored adr	$24,728,000	–	371,739	–	1.83%	–
TSRO	New	TESARO INC	$24,459,000	–	550,000	–	1.81%	–
SLDB	New	SOLID BIOSCIENCES INC	$24,441,000	–	685,956	–	1.81%	–
OMER	New	OMEROS CORP	$23,838,000	–	1,314,118	–	1.76%	–
ARGX	New	ARGENX SEsponsored adr	$23,079,000	–	278,536	–	1.71%	–
ARNA	New	ARENA PHARMACEUTICALS INC	$19,620,000	–	450,000	–	1.45%	–
NBIX	New	NEUROCRINE BIOSCIENCES INC	$18,775,000	–	191,112	–	1.39%	–
VNDA	New	VANDA PHARMACEUTICALS INC	$18,246,000	–	957,821	–	1.35%	–
	New	OMEROS CORPcall	$17,578,000	–	969,000	–	1.30%	–
RETA	New	REATA PHARMACEUTICALS INCcl a	$15,737,000	–	450,000	–	1.16%	–
KNSA	New	KINIKSA PHARMACEUTICALS LTD	$13,842,000	–	831,000	–	1.02%	–
INCY	New	INCYTE CORP	$13,400,000	–	200,000	–	0.99%	–
CLSD	New	CLEARSIDE BIOMEDICAL INC	$12,828,000	–	1,200,000	–	0.95%	–
BOLD	New	AUDENTES THERAPEUTICS INC	$12,340,000	–	322,945	–	0.91%	–
QTRX	New	QUANTERIX CORP	$12,174,000	–	847,788	–	0.90%	–
INSP	New	INSPIRE MED SYS INC	$11,590,000	–	325,000	–	0.86%	–
BHVN	New	BIOHAVEN PHARMACTL HLDG CO L	$11,253,000	–	284,735	–	0.83%	–
ARRY	New	ARRAY BIOPHARMA INC	$11,222,000	–	668,743	–	0.83%	–
GEMP	New	GEMPHIRE THERAPEUTICS INC	$10,614,000	–	1,041,635	–	0.78%	–
ACRS	New	ACLARIS THERAPEUTICS INC	$10,495,000	–	525,538	–	0.78%	–
ABEO	New	ABEONA THERAPEUTICS INC	$8,790,000	–	549,404	–	0.65%	–
ZLAB	New	ZAI LAB LTDadr	$7,746,000	–	333,166	–	0.57%	–
CFRX	New	CONTRAFECT CORP	$7,497,000	–	3,392,234	–	0.56%	–
EIDX	New	EIDOS THERAPEUTICS INC	$7,455,000	–	385,846	–	0.55%	–
HRTX	New	HERON THERAPEUTICS INC	$7,425,000	–	191,108	–	0.55%	–
COLL	New	COLLEGIUM PHARMACEUTICAL INC	$6,837,000	–	286,668	–	0.51%	–
TBIO	New	TRANSLATE BIO INC	$5,750,000	–	454,550	–	0.42%	–
ITRM	New	ITERUM THERAPEUTICS PLC	$5,445,000	–	500,000	–	0.40%	–
SGMO	New	SANGAMO THERAPEUTICS INC	$5,427,000	–	382,192	–	0.40%	–
NERV	New	MINERVA NEUROSCIENCES INC	$5,015,000	–	607,903	–	0.37%	–
XLRN	New	ACCELERON PHARMA INC	$3,477,000	–	71,667	–	0.26%	–
	New	TRILLIUM THERAPEUTICS INC	$3,439,000	–	573,208	–	0.25%	–
	New	INTEC PHARMA LTD JERUSALEM	$3,405,000	–	773,816	–	0.25%	–
MRNS	New	MARINUS PHARMACEUTICALS INC	$3,380,000	–	478,111	–	0.25%	–
SRRK	New	SCHOLAR ROCK HOLDING CORP	$3,277,000	–	210,078	–	0.24%	–
MGTX	New	MEIRAGTX HOLDINGS PLC	$2,734,000	–	238,580	–	0.20%	–
PTGX	New	PROTAGONIST THERAPEUTICS INC	$2,568,000	–	382,139	–	0.19%	–
ONSIW	New	ONCOBIOLOGICS INC*w exp 02/18/201	$20,000	–	416,666	–	0.00%	–
CLRBW	New	CELLECTAR BIOSCIENCES INC*w exp 08/20/201	$10,000	–	52,999	–	0.00%	–

Q4 2017

			Value		Shares		↓ Weighting
CLRBW	Exit	CELLECTAR BIOSCIENCES INC*w exp 08/20/201	$0	–	-52,999	–	-0.00%	–
ONSIZ	Exit	ONCOBIOLOGICS INC*w exp 05/18/201	$0	–	-416,666	–	-0.00%	–
ONSIW	Exit	ONCOBIOLOGICS INC*w exp 02/18/201	$0	–	-416,666	–	-0.01%	–
ONS	Exit	ONCOBIOLOGICS INC	$0	–	-593,883	–	-0.14%	–
CRIS	Exit	CURIS INC	$0	–	-1,150,000	–	-0.30%	–
CTMX	Exit	CYTOMX THERAPEUTICS INC	$0	–	-100,000	–	-0.32%	–
OVID	Exit	OVID THERAPEUTICS INC.	$0	–	-223,972	–	-0.34%	–
XLRN	Exit	ACCELERON PHARMA INC	$0	–	-75,000	–	-0.49%	–
IMDZ	Exit	IMMUNE DESIGN CORP	$0	–	-280,500	–	-0.51%	–
	Exit	TRILLIUM THERAPEUTICS INC	$0	–	-600,000	–	-0.55%	–
COLL	Exit	COLLEGIUM PHARMACEUTICAL INC	$0	–	-300,000	–	-0.56%	–
ARDX	Exit	ARDELYX INC	$0	–	-572,738	–	-0.57%	–
CFRX	Exit	CONTRAFECT CORP	$0	–	-3,550,000	–	-0.70%	–
CBAY	Exit	CYMABAY THERAPEUTICS INC	$0	–	-500,000	–	-0.71%	–
SYRS	Exit	SYROS PHARMACEUTICALS INC	$0	–	-296,296	–	-0.77%	–
WVE	Exit	WAVE LIFE SCIENCES LTD	$0	–	-202,079	–	-0.78%	–
NERV	Exit	MINERVA NEUROSCIENCES INC	$0	–	-607,903	–	-0.82%	–
AAAP	Exit	ADVANCED ACCELERATOR APPLICsponsored ads	$0	–	-75,000	–	-0.90%	–
MRSN	Exit	MERSANA THERAPEUTICS	$0	–	-295,549	–	-0.90%	–
BPMC	Exit	BLUEPRINT MEDICINES CORP	$0	–	-75,000	–	-0.92%	–
AGRX	Exit	AGILE THERAPEUTICS INC	$0	–	-1,250,000	–	-0.98%	–
JNCE	Exit	JOUNCE THERAPEUTICS INC	$0	–	-359,738	–	-0.99%	–
SGMO	Exit	SANGAMO THERAPEUTICS INC	$0	–	-400,000	–	-1.06%	–
ABEO	Exit	ABEONA THERAPEUTICS INC	$0	–	-400,000	–	-1.20%	–
	Exit	INTEC PHARMA LTD JERUSALEM	$0	–	-809,804	–	-1.28%	–
GEMP	Exit	GEMPHIRE THERAPEUTICS INC	$0	–	-800,000	–	-1.33%	–
PTI	Exit	PROTEOSTASIS THERAPEUTICS IN	$0	–	-3,804,027	–	-1.41%	–
PTGX	Exit	PROTAGONIST THERAPEUTICS INC	$0	–	-500,000	–	-1.56%	–
ZLAB	Exit	ZAI LABS LTDadr	$0	–	-333,166	–	-1.59%	–
BOLD	Exit	AUDENTES THERAPEUTICS INC	$0	–	-323,545	–	-1.60%	–
NVRO	Exit	NEVRO CORP	$0	–	-100,000	–	-1.60%	–
HRTX	Exit	HERON THERAPEUTICS INC	$0	–	-570,000	–	-1.62%	–
ALDR	Exit	ALDER BIOPHARMACEUTICALS INC	$0	–	-900,000	–	-1.95%	–
ARRY	Exit	ARRAY BIOPHARMA INC	$0	–	-900,000	–	-1.96%	–
MRTX	Exit	MIRATI THERAPEUTICS INC	$0	–	-1,000,000	–	-2.07%	–
EGRX	Exit	EAGLE PHARMACEUTICALS INC	$0	–	-200,000	–	-2.11%	–
RETA	Exit	REATA PHARMACEUTICALS INCcl a	$0	–	-388,574	–	-2.13%	–
ACRS	Exit	ACLARIS THERAPEUTICS INC	$0	–	-550,000	–	-2.51%	–
NBIX	Exit	NEUROCRINE BIOSCIENCES INC	$0	–	-250,000	–	-2.70%	–
	Exit	OMEROS CORP	$0	–	-750,000	–	-2.86%	–
JUNO	Exit	JUNO THERAPEUTICS INC	$0	–	-375,000	–	-2.97%	–
CLSD	Exit	CLEARSIDE BIOMEDICAL INC	$0	–	-1,940,880	–	-3.00%	–
QTNT	Exit	QUOTIENT LTD	$0	–	-3,485,921	–	-3.03%	–
BLUE	Exit	BLUEBIRD BIO INC	$0	–	-137,500	–	-3.34%	–
GTHX	Exit	G1 THERAPEUTICS, INC.	$0	–	-897,505	–	-3.94%	–
PTLA	Exit	PORTOLA PHARMACEUTICALS INC	$0	–	-500,000	–	-4.77%	–
TBPH	Exit	THERAVANCE BIOPHARMA INC	$0	–	-950,000	–	-5.74%	–
ANAB	Exit	ANAPTYSBIO INC	$0	–	-1,000,000	–	-6.17%	–
OMER	Exit	OMEROS CORP	$0	–	-1,700,000	–	-6.49%	–
RXDX	Exit	IGNYTA INC	$0	–	-3,500,000	–	-7.63%	–
MYOK	Exit	MYOKARDIA INC	$0	–	-1,071,889	–	-8.11%	–

Q3 2017

			Value		Shares		↓ Weighting
MYOK	Buy	MYOKARDIA INC	$45,930,000	+250.6%	1,071,889	+7.2%	8.11%	+273.6%
RXDX	Buy	IGNYTA INC	$43,225,000	+178.4%	3,500,000	+133.3%	7.63%	+196.6%
OMER	Buy	OMEROS CORP	$36,754,000	+42.0%	1,700,000	+30.8%	6.49%	+51.3%
ANAB	Buy	ANAPTYSBIO INC	$34,950,000	+82.7%	1,000,000	+25.1%	6.17%	+94.6%
PTLA	Sell	PORTOLA PHARMACEUTICALS INC	$27,015,000	-46.6%	500,000	-44.4%	4.77%	-43.1%
GTHX	Buy	G1 THERAPEUTICS, INC.	$22,339,000	+166.9%	897,505	+87.0%	3.94%	+184.1%
BLUE	Sell	BLUEBIRD BIO INC	$18,886,000	-34.6%	137,500	-50.0%	3.34%	-30.4%
QTNT	Sell	QUOTIENT LTD	$17,186,000	-34.2%	3,485,921	-1.8%	3.03%	-29.9%
JUNO	Sell	JUNO THERAPEUTICS INC	$16,823,000	-25.0%	375,000	-50.0%	2.97%	-20.1%
	New	OMEROS CORP	$16,215,000	–	750,000	–	2.86%	–
ACRS	Sell	ACLARIS THERAPEUTICS INC	$14,196,000	-27.3%	550,000	-23.6%	2.51%	-22.6%
RETA	New	REATA PHARMACEUTICALS INCcl a	$12,085,000	–	388,574	–	2.13%	–
MRTX	New	MIRATI THERAPEUTICS INC	$11,700,000	–	1,000,000	–	2.07%	–
NVRO	Sell	NEVRO CORP	$9,088,000	-54.8%	100,000	-63.0%	1.60%	-51.8%
ZLAB	New	ZAI LABS LTDadr	$8,995,000	–	333,166	–	1.59%	–
GEMP	Sell	GEMPHIRE THERAPEUTICS INC	$7,552,000	-38.5%	800,000	-16.0%	1.33%	-34.5%
BPMC	Sell	BLUEPRINT MEDICINES CORP	$5,225,000	-72.0%	75,000	-79.6%	0.92%	-70.1%
MRSN	Buy	MERSANA THERAPEUTICS	$5,110,000	+358.3%	295,549	+270.4%	0.90%	+387.6%
NERV	Sell	MINERVA NEUROSCIENCES INC	$4,620,000	-73.9%	607,903	-69.6%	0.82%	-72.2%
CBAY	New	CYMABAY THERAPEUTICS INC	$4,030,000	–	500,000	–	0.71%	–
ARDX	Sell	ARDELYX INC	$3,207,000	-55.8%	572,738	-59.7%	0.57%	-53.0%
IMDZ	Sell	IMMUNE DESIGN CORP	$2,903,000	-11.7%	280,500	-16.8%	0.51%	-5.9%
CTMX	Sell	CYTOMX THERAPEUTICS INC	$1,817,000	-49.0%	100,000	-56.5%	0.32%	-45.7%
CRIS	Sell	CURIS INC	$1,714,000	-54.7%	1,150,000	-42.5%	0.30%	-51.7%
ONS	Sell	ONCOBIOLOGICS INC	$814,000	-19.6%	593,883	-40.8%	0.14%	-14.3%
CLRB	Exit	CELLECTAR BIOSCIENCES INC	$0	–	-53,649	–	-0.01%	–
THLD	Exit	THRESHOLD PHARMACEUTICAL INC	$0	–	-900,000	–	-0.06%	–
NEOS	Exit	NEOS THERAPEUTICS INC	$0	–	-50,613	–	-0.06%	–
HTGM	Exit	HTG MOLECULAR DIAGNOSTICS IN	$0	–	-203,464	–	-0.09%	–
	Exit	ABBVIE INC	$0	–	-6,100	–	-0.16%	–
	Exit	PORTOLA PHARMACEUTICALS INC	$0	–	-1,000	–	-0.19%	–
MYOV	Exit	MYOVANT SCIENCES LTD	$0	–	-100,000	–	-0.19%	–
	Exit	APTOSE BIOSCIENCES INC	$0	–	-990,579	–	-0.20%	–
XNCR	Exit	XENCOR INC	$0	–	-75,000	–	-0.26%	–
ZYME	Exit	ZYMEWORKS INC	$0	–	-232,008	–	-0.32%	–
PFNX	Exit	PFENEX INC	$0	–	-574,966	–	-0.38%	–
REPH	Exit	RECRO PHARMA INC	$0	–	-333,200	–	-0.39%	–
RGNX	Exit	REGENXBIO INC	$0	–	-120,000	–	-0.39%	–
LPCN	Exit	LIPOCINE INC NEW	$0	–	-741,496	–	-0.49%	–
SRNE	Exit	SORRENTO THERAPEUTICS INC	$0	–	-1,690,800	–	-0.56%	–
RIGL	Exit	RIGEL PHARMACEUTICALS INC	$0	–	-1,539,750	–	-0.70%	–
AGEN	Exit	AGENUS INC	$0	–	-1,200,000	–	-0.78%	–
FLGT	Exit	FULGENT GENETICS INC	$0	–	-750,000	–	-0.79%	–
DERM	Exit	DERMIRA INC	$0	–	-170,000	–	-0.82%	–
IVTY	Exit	INVUITY INC	$0	–	-700,000	–	-0.84%	–
DXCM	Exit	DEXCOM INC	$0	–	-70,000	–	-0.85%	–
SGYPQ	Exit	SYNERGY PHARMACEUTICALS INC	$0	–	-1,200,000	–	-0.88%	–
CHRS	Exit	COHERUS BIOSCIENCES INC	$0	–	-620,300	–	-1.48%	–
ALNY	Exit	ALNYLAM PHARMACEUTICALS INC	$0	–	-125,000	–	-1.65%	–
GLPG	Exit	GALAPAGOS NVspon adr	$0	–	-300,000	–	-3.80%	–

Q2 2017

			Value		Shares		↓ Weighting
PTLA	New	PORTOLA PHARMACEUTICALS INC	$50,553,000	–	900,000	–	8.38%	–
TBPH	New	THERAVANCE BIOPHARMA INC	$37,848,000	–	950,000	–	6.27%	–
BLUE	New	BLUEBIRD BIO INC	$28,889,000	–	275,000	–	4.79%	–
QTNT	New	QUOTIENT LTD	$26,121,000	–	3,549,000	–	4.33%	–
OMER	New	OMEROS CORP	$25,877,000	–	1,300,000	–	4.29%	–
GLPG	New	GALAPAGOS NVspon adr	$22,918,000	–	300,000	–	3.80%	–
JUNO	New	JUNO THERAPEUTICS INC	$22,418,000	–	750,000	–	3.72%	–
NVRO	New	NEVRO CORP	$20,096,000	–	270,000	–	3.33%	–
ACRS	New	ACLARIS THERAPEUTICS INC	$19,526,000	–	720,000	–	3.24%	–
ANAB	New	ANAPTYSBIO	$19,131,000	–	799,469	–	3.17%	–
BPMC	New	BLUEPRINT MEDICINES CORP	$18,641,000	–	367,900	–	3.09%	–
PTI	New	PROTEOSTASIS THERAPEUTICS IN	$17,803,000	–	3,804,027	–	2.95%	–
CLSD	New	CLEARSIDE BIOMEDICAL INC	$17,681,000	–	1,940,880	–	2.93%	–
NERV	New	MINERVA NEUROSCIENCES INC	$17,677,000	–	1,997,412	–	2.93%	–
EGRX	New	EAGLE PHARMACEUTICALS INC	$15,778,000	–	200,000	–	2.62%	–
RXDX	New	IGNYTA INC	$15,525,000	–	1,500,000	–	2.57%	–
MYOK	New	MYOKARDIA INC	$13,100,000	–	1,000,000	–	2.17%	–
GEMP	New	GEMPHIRE THERAPEUTICS INC	$12,282,000	–	952,798	–	2.04%	–
NBIX	New	NEUROCRINE BIOSCIENCES INC	$11,500,000	–	250,000	–	1.91%	–
ALDR	New	ALDER BIOPHARMACEUTICALS INC	$10,305,000	–	900,000	–	1.71%	–
ALNY	New	ALNYLAM PHARMACEUTICALS INC	$9,970,000	–	125,000	–	1.65%	–
CHRS	New	COHERUS BIOSCIENCES INC	$8,901,000	–	620,300	–	1.48%	–
GTHX	New	G1 THERAPEUTICS INC	$8,371,000	–	479,986	–	1.39%	–
HRTX	New	HERON THERAPEUTICS INC	$7,894,000	–	570,000	–	1.31%	–
ARRY	New	ARRAY BIOPHARMA INC	$7,533,000	–	900,000	–	1.25%	–
ARDX	New	ARDELYX INC	$7,256,000	–	1,422,738	–	1.20%	–
BOLD	New	AUDENTES THERAPEUTICS, INC	$6,189,000	–	323,545	–	1.03%	–
PTGX	New	PROTAGONIST THERAPEUTICS INC	$5,655,000	–	500,000	–	0.94%	–
SGYPQ	New	SYNERGY PHARMACEUTICALS INC	$5,340,000	–	1,200,000	–	0.88%	–
CFRX	New	CONTRAFECT CORP	$5,148,000	–	3,550,000	–	0.85%	–
DXCM	New	DEXCOM INC	$5,121,000	–	70,000	–	0.85%	–
IVTY	New	INVUITY INC	$5,075,000	–	700,000	–	0.84%	–
JNCE	New	JOUNCE THERAPEUTICS INC	$5,047,000	–	359,738	–	0.84%	–
DERM	New	DERMIRA INC	$4,954,000	–	170,000	–	0.82%	–
FLGT	New	FULGENT GENETICS INC	$4,793,000	–	750,000	–	0.79%	–
SYRS	New	SYROS PHARMACEUTICALS INC	$4,767,000	–	296,296	–	0.79%	–
AGEN	New	AGENUS INC	$4,692,000	–	1,200,000	–	0.78%	–
AGRX	New	AGILE THERAPEUTICS INC	$4,688,000	–	1,250,000	–	0.78%	–
	New	INTEC PHARMA LTD JERUSALEM	$4,616,000	–	809,804	–	0.76%	–
RIGL	New	RIGEL PHARMACEUTICALS INC	$4,204,000	–	1,539,750	–	0.70%	–
CRIS	New	CURIS INC	$3,780,000	–	2,000,000	–	0.63%	–
WVE	New	WAVE LIFE SCIENCES LTD	$3,759,000	–	202,079	–	0.62%	–
COLL	New	COLLEGIUM PHARMACEUTICAL INC	$3,753,000	–	300,000	–	0.62%	–
CTMX	New	CYTOMX THERAPEUTICS INC	$3,565,000	–	230,000	–	0.59%	–
SGMO	New	SANGAMO THERAPEUTICS INC	$3,520,000	–	400,000	–	0.58%	–
SRNE	New	SORRENTO THERAPEUTICS INC	$3,382,000	–	1,690,800	–	0.56%	–
IMDZ	New	IMMUNE DESIGN CORP	$3,286,000	–	337,000	–	0.54%	–
LPCN	New	LIPOCINE INC NEW	$2,981,000	–	741,496	–	0.49%	–
AAAP	New	ADVANCED ACCELERATOR APPLICsponsored ads	$2,928,000	–	75,000	–	0.48%	–
	New	TRILLIUM THERAPEUTICS INC	$2,640,000	–	600,000	–	0.44%	–
ABEO	New	ABEONA THERAPEUTICS INC	$2,560,000	–	400,000	–	0.42%	–
RGNX	New	REGENXBIO INC	$2,370,000	–	120,000	–	0.39%	–
OVID	New	OVID THERAPEUTICS INC.	$2,349,000	–	223,972	–	0.39%	–
REPH	New	RECRO PHARMA INC	$2,343,000	–	333,200	–	0.39%	–
PFNX	New	PFENEX INC	$2,306,000	–	574,966	–	0.38%	–
XLRN	New	ACCELERON PHARMA INC	$2,279,000	–	75,000	–	0.38%	–
ZYME	New	ZYMEWORKS INC	$1,937,000	–	232,008	–	0.32%	–
XNCR	New	XENCOR INC	$1,583,000	–	75,000	–	0.26%	–
	New	APTOSE BIOSCIENCES INC	$1,218,000	–	990,579	–	0.20%	–
MYOV	New	MYOVANT SCIENCES LTD	$1,170,000	–	100,000	–	0.19%	–
	New	PORTOLA PHARMACEUTICALS INC	$1,160,000	–	1,000	–	0.19%	–
MRSN	New	MERSANA THERAPEUTICS INC	$1,115,000	–	79,798	–	0.18%	–
ONS	New	ONCOBIOLOGICS INC	$1,013,000	–	1,002,516	–	0.17%	–
	New	ABBVIE INC	$939,000	–	6,100	–	0.16%	–
HTGM	New	HTG MOLECULAR DIAGNOSTICS IN	$541,000	–	203,464	–	0.09%	–
NEOS	New	NEOS THERAPEUTICS INC	$369,000	–	50,613	–	0.06%	–
THLD	New	THRESHOLD PHARMACEUTICAL INC	$354,000	–	900,000	–	0.06%	–
CLRB	New	CELLECTAR BIOSCIENCES INC	$87,000	–	53,649	–	0.01%	–
ONSIW	New	ONCOBIOLOGICS INC*w exp 02/18/201	$72,000	–	416,666	–	0.01%	–
ONSIZ	New	ONCOBIOLOGICS INC*w exp 05/18/201	$39,000	–	416,666	–	0.01%	–
CLRBW	New	CELLECTAR BIOSCIENCES INC*w exp 08/20/201	$12,000	–	52,999	–	0.00%	–

Q4 2016

			Value		Shares		↓ Weighting
CLRBW	Exit	CELLECTAR BIOSCIENCES INC*w exp 08/20/201	$0	–	-52,999	–	-0.00%	–
PVCTW	Exit	PROVECTUS BIOPHARMACEUTICALS*w exp 06/19/202	$0	–	-2,200,000	–	-0.01%	–
CLRB	Exit	CELLECTAR BIOSCIENCES INC	$0	–	-53,649	–	-0.02%	–
AGTC	Exit	APPLIED GENETIC TECHNOL CORP	$0	–	-17,321	–	-0.02%	–
ADAP	Exit	ADAPTIMMUNE THERAPEUTICS PLCsponds adr	$0	–	-25,307	–	-0.02%	–
ONSIW	Exit	ONCOBIOLOGICS INC*w exp 02/18/201	$0	–	-416,666	–	-0.02%	–
PVCT	Exit	PROVECTUS BIOPHARMACEUTICALS	$0	–	-2,226,961	–	-0.02%	–
NEOS	Exit	NEOS THERAPEUTICS INC	$0	–	-50,613	–	-0.04%	–
GNVC	Exit	GENVEC INC	$0	–	-1,015,685	–	-0.05%	–
HTGM	Exit	HTG MOLECULAR DIAGNOSTICS IN	$0	–	-203,464	–	-0.05%	–
ONSIZ	Exit	ONCOBIOLOGICS INC*w exp 05/18/201	$0	–	-416,666	–	-0.06%	–
THLD	Exit	THRESHOLD PHARMACEUTICAL INC	$0	–	-1,012,255	–	-0.08%	–
NSTG	Exit	NANOSTRING TECHNOLOGIES INC	$0	–	-40,490	–	-0.09%	–
AVEO	Exit	AVEO PHARMACEUTICALS INC	$0	–	-1,087,715	–	-0.11%	–
FOLD	Exit	AMICUS THERAPEUTICS INC	$0	–	-151,838	–	-0.12%	–
ASND	Exit	ASCENDIS PHARMA A Ssponsored adr	$0	–	-62,254	–	-0.14%	–
EPZM	Exit	EPIZYME INC	$0	–	-159,513	–	-0.17%	–
CYAD	Exit	CELYAD SAadr	$0	–	-75,920	–	-0.20%	–
AQXP	Exit	AQUINOX PHARMACEUTICALS INC	$0	–	-151,838	–	-0.22%	–
GLYC	Exit	GLYCOMIMETICS INC	$0	–	-287,031	–	-0.23%	–
RGNX	Exit	REGENXBIO INC	$0	–	-156,741	–	-0.24%	–
	Exit	APTOSE BIOSCIENCES INC	$0	–	-990,579	–	-0.25%	–
IMDZ	Exit	IMMUNE DESIGN CORP	$0	–	-432,990	–	-0.36%	–
LPCN	Exit	LIPOCINE INC NEW	$0	–	-751,296	–	-0.37%	–
CRVS	Exit	CORVUS PHARMACEUTICALS INC	$0	–	-214,132	–	-0.39%	–
SNDX	Exit	SYNDAX PHARMACEUTICALS INC	$0	–	-240,403	–	-0.40%	–
AGRX	Exit	AGILE THERAPEUTICS INC	$0	–	-563,880	–	-0.43%	–
ATRA	Exit	ATARA BIOTHERAPEUTICS INC	$0	–	-186,460	–	-0.44%	–
LBIO	Exit	LION BIOTECHNOLOGIES INC	$0	–	-505,941	–	-0.46%	–
RIGL	Exit	RIGEL PHARMACEUTICALS INC	$0	–	-1,155,600	–	-0.47%	–
ONS	Exit	ONCOBIOLOGICS INC	$0	–	-1,027,216	–	-0.48%	–
XLRN	Exit	ACCELERON PHARMA INC	$0	–	-127,451	–	-0.51%	–
	Exit	INTEC PHARMA LTD JERUSALEM	$0	–	-809,804	–	-0.52%	–
CATB	Exit	CATABASIS PHARMACEUTICALS IN	$0	–	-800,000	–	-0.54%	–
AVXS	Exit	AVEXIS INC	$0	–	-131,858	–	-0.60%	–
PFNX	Exit	PFENEX INC	$0	–	-632,559	–	-0.62%	–
DERM	Exit	DERMIRA INC	$0	–	-172,083	–	-0.64%	–
CTMX	Exit	CYTOMX THERAPEUTICS INC	$0	–	-371,636	–	-0.64%	–
REPH	Exit	RECRO PHARMA INC	$0	–	-669,239	–	-0.65%	–
ZYNE	Exit	ZYNERBA PHARMACEUTICALS INC	$0	–	-480,501	–	-0.69%	–
CRIS	Exit	CURIS INC	$0	–	-2,410,900	–	-0.69%	–
SGMO	Exit	SANGAMO BIOSCIENCES INC	$0	–	-1,402,331	–	-0.72%	–
FWP	Exit	FORWARD PHARMA A/Ssponsored adr	$0	–	-339,175	–	-0.78%	–
FLGT	Exit	FULGENT GENETICS INC	$0	–	-800,000	–	-0.81%	–
ARRY	Exit	ARRAY BIOPHARMA INC	$0	–	-1,150,000	–	-0.86%	–
RARE	Exit	ULTRAGENYX PHARMACEUTICAL IN	$0	–	-110,842	–	-0.87%	–
EBS	Exit	EMERGENT BIOSOLUTIONS INC	$0	–	-250,000	–	-0.87%	–
BOLD	Exit	AUDENTES THERAPEUTICS INC	$0	–	-449,660	–	-0.88%	–
ACHN	Exit	ACHILLION PHARMACEUTICALS	$0	–	-1,006,128	–	-0.90%	–
ALNY	Exit	ALNYLAM PHARMACEUTICALS INC	$0	–	-126,120	–	-0.94%	–
COLL	Exit	COLLEGIUM PHARMACEUTICAL INC	$0	–	-455,515	–	-0.97%	–
DXCM	Exit	DEXCOM INC	$0	–	-100,000	–	-0.97%	–
BPMC	Exit	BLUEPRINT MEDICINES CORP	$0	–	-298,870	–	-0.98%	–
INCR	Exit	INC RESH HLDGS INCcl a	$0	–	-200,000	–	-0.98%	–
CFRX	Exit	CONTRAFECT CORP	$0	–	-3,840,966	–	-1.05%	–
GEMP	Exit	GEMPHIRE THERAPEUTICS INC	$0	–	-900,000	–	-1.08%	–
ADXS	Exit	ADVAXIS INC	$0	–	-920,915	–	-1.09%	–
IVTY	Exit	INVUITY INC	$0	–	-767,466	–	-1.16%	–
AGEN	Exit	AGENUS INC	$0	–	-1,578,106	–	-1.25%	–
CLLS	Exit	CELLECTIS S Asponsored ads	$0	–	-498,117	–	-1.32%	–
PTLA	Exit	PORTOLA PHARMACEUTICALS INC	$0	–	-596,000	–	-1.49%	–
CRBP	Exit	CORBUS PHARMACEUTICALS HLDGS	$0	–	-2,000,000	–	-1.50%	–
CBPO	Exit	CHINA BIOLOGIC PRODS INC	$0	–	-112,867	–	-1.55%	–
CHRS	Exit	COHERUS BIOSCIENCES INC	$0	–	-576,106	–	-1.70%	–
SRNE	Exit	SORRENTO THERAPEUTICS INC	$0	–	-2,121,013	–	-1.81%	–
WVE	Exit	WAVE LIFE SCIENCES LTD	$0	–	-507,907	–	-1.82%	–
PTGX	Exit	PROTAGONIST THERAPEUTICS INC	$0	–	-800,000	–	-1.86%	–
OMER	Exit	OMEROS CORP	$0	–	-1,695,000	–	-2.09%	–
NBIX	Exit	NEUROCRINE BIOSCIENCES INC	$0	–	-398,301	–	-2.22%	–
MGNX	Exit	MACROGENICS INC	$0	–	-707,978	–	-2.34%	–
GLPG	Exit	GALAPAGOS NVspon adr	$0	–	-334,044	–	-2.36%	–
QTNT	Exit	QUOTIENT LTD	$0	–	-2,787,717	–	-2.40%	–
ACRS	Exit	ACLARIS THERAPEUTICS INC	$0	–	-901,286	–	-2.54%	–
CLVS	Exit	CLOVIS ONCOLOGY INC	$0	–	-650,000	–	-2.58%	–
MYOK	Exit	MYOKARDIA INC	$0	–	-1,605,790	–	-2.89%	–
ARDX	Exit	ARDELYX INC	$0	–	-2,071,964	–	-2.96%	–
HRTX	Exit	HERON THERAPEUTICS INC	$0	–	-1,771,263	–	-3.36%	–
EGRX	Exit	EAGLE PHARMACEUTICALS INC	$0	–	-455,995	–	-3.52%	–
CLSD	Exit	CLEARSIDE BIOMEDICAL INC	$0	–	-1,988,208	–	-3.80%	–
PTI	Exit	PROTEOSTASIS THERAPEUTICS IN	$0	–	-2,350,000	–	-4.04%	–
NERV	Exit	MINERVA NEUROSCIENCES INC	$0	–	-2,800,000	–	-4.36%	–
TBPH	Exit	THERAVANCE BIOPHARMA INC	$0	–	-1,118,372	–	-4.47%	–
NVRO	Exit	NEVRO CORP	$0	–	-491,044	–	-5.65%	–
ALDR	Exit	ALDER BIOPHARMACEUTICALS INC	$0	–	-1,689,071	–	-6.10%	–

Q3 2016

			Value		Shares		↓ Weighting
PTI	Buy	PROTEOSTASIS THERAPEUTICS IN	$36,636,000	+123.0%	2,350,000	+73.5%	4.04%	+73.4%
EGRX	Sell	EAGLE PHARMACEUTICALS INC	$31,920,000	+62.6%	455,995	-9.9%	3.52%	+26.5%
ARDX	Buy	ARDELYX INC	$26,811,000	+104.9%	2,071,964	+38.2%	2.96%	+59.3%
MYOK	Buy	MYOKARDIA INC	$26,239,000	+179.0%	1,605,790	+111.8%	2.89%	+117.0%
CLVS	New	CLOVIS ONCOLOGY INC	$23,433,000	–	650,000	–	2.58%	–
QTNT	Buy	QUOTIENT LTD	$21,800,000	+82.9%	2,787,717	+81.3%	2.40%	+42.2%
OMER	Sell	OMEROS CORP	$18,916,000	+5.2%	1,695,000	-0.9%	2.09%	-18.2%
PTGX	New	PROTAGONIST THERAPEUTICS INC	$16,904,000	–	800,000	–	1.86%	–
WVE	Buy	WAVE LIFE SCIENCES LTD	$16,492,000	+102.1%	507,907	+28.8%	1.82%	+57.2%
PTLA	Buy	PORTOLA PHARMACEUTICALS INC	$13,535,000	+44.8%	596,000	+50.5%	1.49%	+12.7%
IVTY	Buy	INVUITY INC	$10,530,000	+3130.1%	767,466	+2144.1%	1.16%	+2423.9%
ADXS	Buy	ADVAXIS INC	$9,845,000	+50.3%	920,915	+13.7%	1.09%	+16.9%
GEMP	New	GEMPHIRE THERAPEUTICS INC	$9,828,000	–	900,000	–	1.08%	–
CFRX	Buy	CONTRAFECT CORP	$9,526,000	+292.0%	3,840,966	+356.7%	1.05%	+204.3%
BPMC	Buy	BLUEPRINT MEDICINES CORP	$8,876,000	+333.0%	298,870	+195.3%	0.98%	+236.4%
ALNY	Sell	ALNYLAM PHARMACEUTICALS INC	$8,548,000	-23.1%	126,120	-37.1%	0.94%	-40.2%
BOLD	New	AUDENTES THERAPEUTICS INC	$8,008,000	–	449,660	–	0.88%	–
EBS	New	EMERGENT BIOSOLUTIONS INC	$7,883,000	–	250,000	–	0.87%	–
ARRY	New	ARRAY BIOPHARMA INC	$7,763,000	–	1,150,000	–	0.86%	–
FLGT	New	FULGENT GENETICS INC	$7,376,000	–	800,000	–	0.81%	–
CRIS	Buy	CURIS INC	$6,292,000	+242.7%	2,410,900	+104.9%	0.69%	+166.9%
REPH	Sell	RECRO PHARMA INC	$5,916,000	-4.4%	669,239	-14.0%	0.65%	-25.7%
AVXS	New	AVEXIS INC	$5,434,000	–	131,858	–	0.60%	–
CATB	New	CATABASIS PHARMACEUTICALS IN	$4,928,000	–	800,000	–	0.54%	–
RIGL	New	RIGEL PHARMACEUTICALS INC	$4,241,000	–	1,155,600	–	0.47%	–
SNDX	Buy	SYNDAX PHARMACEUTICALS INC	$3,645,000	+72.6%	240,403	+12.1%	0.40%	+34.4%
GNVC	Sell	GENVEC INC	$468,000	-31.4%	1,015,685	-14.7%	0.05%	-46.4%
	Exit	TETRALOGIC PHARMACEUTICALS Cnote 8.000% 6/1	$0	–	-5,000,000	–	-0.12%	–
AGIO	Exit	AGIOS PHARMACEUTICALS INC	$0	–	-50,000	–	-0.30%	–
MCRB	Exit	SERES THERAPEUTICS INC	$0	–	-253,064	–	-1.04%	–
RLYP	Exit	RELYPSA INC	$0	–	-450,000	–	-1.18%	–
DVAX	Exit	DYNAVAX TECHNOLOGIES CORP	$0	–	-635,000	–	-1.31%	–
NVAX	Exit	NOVAVAX INC	$0	–	-1,619,608	–	-1.67%	–
VTAE	Exit	VITAE PHARMACEUTICALS INC	$0	–	-1,754,795	–	-2.68%	–
SAGE	Exit	SAGE THERAPEUTICS INC	$0	–	-730,000	–	-3.12%	–
NKTR	Exit	NEKTAR THERAPEUTICS	$0	–	-2,022,879	–	-4.08%	–
TSRO	Exit	TESARO INC	$0	–	-362,875	–	-4.32%	–

Q2 2016

			Value		Shares		↓ Weighting
ALDR	New	ALDER BIOPHARMACEUTICALS INC	$42,176,000	–	1,689,071	–	5.98%	–
NVRO	New	NEVRO CORP	$36,219,000	–	491,044	–	5.14%	–
HRTX	New	HERON THERAPEUTICS INC	$31,971,000	–	1,771,263	–	4.53%	–
TSRO	New	TESARO INC	$30,500,000	–	362,875	–	4.32%	–
NKTR	New	NEKTAR THERAPEUTICS	$28,786,000	–	2,022,879	–	4.08%	–
NERV	New	MINERVA NEUROSCIENCES INC	$28,588,000	–	2,800,000	–	4.05%	–
TBPH	New	THERAVANCE BIOPHARMA INC	$25,376,000	–	1,118,372	–	3.60%	–
SAGE	New	SAGE THERAPEUTICS INC	$21,995,000	–	730,000	–	3.12%	–
EGRX	New	EAGLE PHARMACEUTICALS INC	$19,628,000	–	505,995	–	2.78%	–
MGNX	New	MACROGENICS INC	$19,108,000	–	707,978	–	2.71%	–
VTAE	New	VITAE PHARMACEUTICALS INC	$18,934,000	–	1,754,795	–	2.68%	–
GLPG	New	GALAPAGOS NVspon adr	$18,347,000	–	334,044	–	2.60%	–
NBIX	New	NEUROCRINE BIOSCIENCES INC	$18,103,000	–	398,301	–	2.57%	–
OMER	New	OMEROS CORP	$17,989,000	–	1,710,000	–	2.55%	–
ACRS	New	ACLARIS THERAPEUTICS INC	$16,647,000	–	901,286	–	2.36%	–
PTI	New	PROTEOSTASIS THERAPEUTICS IN	$16,428,000	–	1,354,339	–	2.33%	–
CLSD	New	CLEARSIDE BIOMEDICAL INC	$13,937,000	–	1,988,208	–	1.98%	–
CLLS	New	CELLECTIS S Asponsored ads	$13,245,000	–	498,117	–	1.88%	–
ARDX	New	ARDELYX INC	$13,088,000	–	1,499,226	–	1.86%	–
CBPO	New	CHINA BIOLOGIC PRODS INC	$12,000,000	–	112,867	–	1.70%	–
QTNT	New	QUOTIENT LTD	$11,917,000	–	1,537,717	–	1.69%	–
SRNE	New	SORRENTO THERAPEUTICS INC	$11,878,000	–	2,121,013	–	1.68%	–
NVAX	New	NOVAVAX INC	$11,775,000	–	1,619,608	–	1.67%	–
ALNY	New	ALNYLAM PHARMACEUTICALS INC	$11,118,000	–	200,355	–	1.58%	–
CHRS	New	COHERUS BIOSCIENCES INC	$9,730,000	–	576,106	–	1.38%	–
MYOK	New	MYOKARDIA INC	$9,403,000	–	758,290	–	1.33%	–
PTLA	New	PORTOLA PHARMACEUTICALS INC	$9,346,000	–	396,000	–	1.32%	–
DVAX	New	DYNAVAX TECHNOLOGIES CORP	$9,258,000	–	635,000	–	1.31%	–
RLYP	New	RELYPSA INC	$8,325,000	–	450,000	–	1.18%	–
WVE	New	WAVE LIFE SCIENCES LTD	$8,160,000	–	394,407	–	1.16%	–
SGMO	New	SANGAMO BIOSCIENCES INC	$8,119,000	–	1,402,331	–	1.15%	–
DXCM	New	DEXCOM INC	$7,933,000	–	100,000	–	1.12%	–
ACHN	New	ACHILLION PHARMACEUTICALS IN	$7,848,000	–	1,006,128	–	1.11%	–
INCR	New	INC RESH HLDS INC CL Acl a	$7,626,000	–	200,000	–	1.08%	–
MCRB	New	SERES THERAPEUTICS INC	$7,352,000	–	253,064	–	1.04%	–
ADXS	New	ADVAXIS INC	$6,551,000	–	809,804	–	0.93%	–
AGEN	New	AGENUS INC	$6,391,000	–	1,578,106	–	0.91%	–
REPH	New	RECRO PHARMA INC	$6,187,000	–	778,288	–	0.88%	–
FWP	New	FORWARD PHARMA A/Ssponsored adr	$6,163,000	–	339,175	–	0.87%	–
CRBP	New	CORBUS PHARMACEUTICALS HLDGS	$5,980,000	–	2,000,000	–	0.85%	–
RARE	New	ULTRAGENYX PHARMACEUTICAL INC	$5,421,000	–	110,842	–	0.77%	–
COLL	New	COLLEGIUM PHARMACEUTICAL INC	$5,398,000	–	455,515	–	0.76%	–
PFNX	New	PFENEX INC	$5,295,000	–	632,559	–	0.75%	–
DERM	New	DERMIRA INC	$5,033,000	–	172,083	–	0.71%	–
XLRN	New	ACCELERON PHARMA INC	$4,331,000	–	127,451	–	0.61%	–
AGRX	New	AGILE THERAPEUTICS INC	$4,291,000	–	563,880	–	0.61%	–
ATRA	New	ATARA BIOTHERAPEUTICS INC	$4,197,000	–	186,460	–	0.60%	–
LBIO	New	LION BIOTECHNOLOGIES INC	$4,098,000	–	505,941	–	0.58%	–
CTMX	New	CYTOMX THERAPEUTICS	$3,796,000	–	371,636	–	0.54%	–
	New	INTEC PHARMA LTD JERUSALEM	$3,724,000	–	809,804	–	0.53%	–
IMDZ	New	IMMUNE DESIGN CORP	$3,533,000	–	432,990	–	0.50%	–
ONS	New	ONCOBIOLOGICS INC	$3,493,000	–	1,027,216	–	0.50%	–
ZYNE	New	ZYNERBA PHARMACEUTICALS INC	$3,291,000	–	480,501	–	0.47%	–
CRVS	New	CORVUS PHARMACEUTICALS INC	$3,054,000	–	214,132	–	0.43%	–
CFRX	New	CONTRAFECT CORP	$2,430,000	–	840,966	–	0.34%	–
	New	APTOSE BIOSCIENCES INC	$2,417,000	–	990,579	–	0.34%	–
LPCN	New	LIPOCINE INC NEW	$2,284,000	–	751,296	–	0.32%	–
SNDX	New	SYNDAX PHARMACEUTICALS INC	$2,112,000	–	214,419	–	0.30%	–
AGIO	New	AGIOS PHARMACEUTICALS INC	$2,095,000	–	50,000	–	0.30%	–
GLYC	New	GLYCOMIMETICS INC	$2,087,000	–	287,031	–	0.30%	–
BPMC	New	BLUEPRINT MEDICINES CORP	$2,050,000	–	101,226	–	0.29%	–
CYAD	New	CELYAD SAadr	$1,896,000	–	75,920	–	0.27%	–
CRIS	New	CURIS INC	$1,836,000	–	1,176,645	–	0.26%	–
EPZM	New	EPIZYME INC	$1,633,000	–	159,513	–	0.23%	–
RGNX	New	REGENXBIO INC	$1,254,000	–	156,741	–	0.18%	–
AVEO	New	AVEO PHARMACEUTICALS INC	$1,045,000	–	1,087,715	–	0.15%	–
AQXP	New	AQUINOX PHARMACEUTICALS INC	$1,005,000	–	151,838	–	0.14%	–
	New	TETRALOGIC PHARMACEUTICALS Cnote 8.000% 6/1	$856,000	–	5,000,000	–	0.12%	–
FOLD	New	AMICUS THERAPEUTICS INC	$829,000	–	151,838	–	0.12%	–
ASND	New	ASCENDIS PHARMA A Ssponsored adr	$826,000	–	62,254	–	0.12%	–
PVCT	New	PROVECTUS BIOPHARMACEUTICALS	$824,000	–	2,226,961	–	0.12%	–
GNVC	New	GENVEC INC	$682,000	–	1,190,650	–	0.10%	–
THLD	New	THRESHOLD PHARMACEUTICALS INC	$643,000	–	1,012,255	–	0.09%	–
HTGM	New	HTG MOLECULAR DIAGNOSTICS IN	$529,000	–	203,464	–	0.08%	–
NSTG	New	NANOSTRING TECHNOLOGIES INC	$510,000	–	40,490	–	0.07%	–
NEOS	New	NEOS THERAPEUTICS INC	$470,000	–	50,613	–	0.07%	–
PVCTW	New	PROVECTUS BIOPHARMACEUTICALS*w exp 06/19/202	$414,000	–	2,200,000	–	0.06%	–
IVTY	New	INVUITY INC	$326,000	–	34,200	–	0.05%	–
AGTC	New	APPLIED GENETIC TECHNOL CORP	$245,000	–	17,321	–	0.04%	–
ADAP	New	ADAPTIMMUNE THERAPEUTICS PLCsponds adr	$206,000	–	25,307	–	0.03%	–
ONSIW	New	ONCOBIOLOGICS INC*w exp 02/18/201	$192,000	–	416,666	–	0.03%	–
ONSIZ	New	ONCOBIOLOGICS INC*w exp 05/18/201	$187,000	–	416,666	–	0.03%	–
CLRB	New	CELLECTAR BIOSCIENCES INC	$185,000	–	53,649	–	0.03%	–
CLRBW	New	CELLECTAR BIOSCIENCES INC*w exp 08/20/201	$29,000	–	52,999	–	0.00%	–

Q4 2015

			Value		Shares		↓ Weighting
	Exit	HERON THERAPEUTICS INC	$0	–	-5,000	–	-0.02%	–
AGTC	Exit	APPLIED GENETIC TECHNOL CORP	$0	–	-17,110	–	-0.04%	–
ADAP	Exit	ADAPTIMMUNE THERAPEUTICS PLCsponds adr	$0	–	-25,000	–	-0.05%	–
CLLS	Exit	CELLECTIS S Asponsored ads	$0	–	-11,300	–	-0.05%	–
CLRBW	Exit	CELLECTAR BIOSCIENCES INC*w exp 08/19/201	$0	–	-530,000	–	-0.07%	–
NSTG	Exit	NANOSTRING TECHNOLOGIES INC	$0	–	-40,000	–	-0.10%	–
VCYT	Exit	VERACYTE INC	$0	–	-137,990	–	-0.10%	–
BITI	Exit	BIOTIE THERAPIES OYJsponsored adr	$0	–	-50,000	–	-0.10%	–
GALT	Exit	GALECTIN THERAPEUTICS INC	$0	–	-286,200	–	-0.11%	–
PVCTW	Exit	PROVECTUS BIOPHARMACEUTICALS*w exp 06/24/202	$0	–	-2,200,000	–	-0.11%	–
AKTX	Exit	AKARI THERAPEUTICS PLCsponsored adr	$0	–	-28,650	–	-0.11%	–
SCYX	Exit	SCYNEXIS INC	$0	–	-99,366	–	-0.12%	–
AKBA	Exit	AKEBIA THERAPEUTICS INC	$0	–	-100,300	–	-0.16%	–
CLRB	Exit	CELLECTAR BIOSCIENCES INC	$0	–	-530,000	–	-0.17%	–
CFRX	Exit	CONTRAFECT CORP	$0	–	-234,406	–	-0.17%	–
NEOS	Exit	NEOS THERAPEUTICS INC	$0	–	-50,000	–	-0.17%	–
ASND	Exit	ASCENDIS PHARMA A Ssponsored adr	$0	–	-61,500	–	-0.17%	–
DNAI	Exit	PRONAI THERAPEUTICS INC	$0	–	-53,153	–	-0.17%	–
AGRX	Exit	AGILE THERAPEUTICS INC	$0	–	-182,053	–	-0.20%	–
PVCT	Exit	PROVECTUS BIOPHARMACEUTICALS	$0	–	-2,200,000	–	-0.20%	–
HTGM	Exit	HTG MOLECULAR DIAGNOSTICS IN	$0	–	-201,000	–	-0.24%	–
QTNTW	Exit	QUOTIENT LTD*w exp 10/30/201	$0	–	-500,000	–	-0.26%	–
KIN	Exit	KINDRED BIOSCIENCES INC	$0	–	-328,497	–	-0.27%	–
AVEO	Exit	AVEO PHARMACEUTICALS INC	$0	–	-1,587,715	–	-0.31%	–
VSAR	Exit	VERSARTIS INC	$0	–	-170,000	–	-0.31%	–
DRNA	Exit	DICERNA PHARMACEUTICALS INC	$0	–	-245,000	–	-0.32%	–
CERU	Exit	CERULEAN PHARMA INC	$0	–	-551,354	–	-0.32%	–
SGMO	Exit	SANGAMO BIOSCIENCES INC	$0	–	-361,000	–	-0.32%	–
FOLD	Exit	AMICUS THERAPEUTICS INC	$0	–	-150,000	–	-0.34%	–
AQXP	Exit	AQUINOX PHARMACEUTICALS INC	$0	–	-150,000	–	-0.34%	–
BPMC	Exit	BLUEPRINT MEDICINES CORP	$0	–	-100,000	–	-0.34%	–
OVAS	Exit	OVASCIENCE INC	$0	–	-252,180	–	-0.34%	–
IMDZ	Exit	IMMUNE DESIGN CORP	$0	–	-189,000	–	-0.37%	–
GLYC	Exit	GLYCOMIMETICS INC	$0	–	-458,955	–	-0.41%	–
ACRX	Exit	ACELRX PHARMACEUTICALS INC	$0	–	-850,000	–	-0.41%	–
	Exit	TETRALOGIC PHARMACEUTICALS Cnote 8.000% 6/1	$0	–	-5,000,000	–	-0.42%	–
GNVC	Exit	GENVEC INC	$0	–	-1,176,235	–	-0.43%	–
LBIO	Exit	LION BIOTECHNOLOGIES INC	$0	–	-499,815	–	-0.46%	–
CYAD	Exit	CELYAD SAadr	$0	–	-75,000	–	-0.50%	–
KPTI	Exit	KARYOPHARM THERAPEUTICS INC	$0	–	-300,987	–	-0.51%	–
EPZM	Exit	EPIZYME INC	$0	–	-266,250	–	-0.55%	–
RGNX	Exit	REGENXBIO INC	$0	–	-156,741	–	-0.55%	–
KITE	Exit	KITE PHARMA INC	$0	–	-68,800	–	-0.61%	–
ARRY	Exit	ARRAY BIOPHARMA INC	$0	–	-850,000	–	-0.62%	–
EPRSQ	Exit	EPIRUS BIOPHARMACEUTICALS INC	$0	–	-896,600	–	-0.63%	–
DERM	Exit	DERMIRA INC	$0	–	-170,000	–	-0.63%	–
NKTR	Exit	NEKTAR THERAPEUTICS	$0	–	-397,500	–	-0.70%	–
	Exit	INTEC PHARMA LTD JERUSALEM	$0	–	-800,000	–	-0.72%	–
	Exit	APTOSE BIOSCIENCES INC	$0	–	-1,081,867	–	-0.75%	–
ATRA	Exit	ATARA BIOTHERAPEUTICS INC	$0	–	-150,000	–	-0.75%	–
XLRN	Exit	ACCELERON PHARMA INC	$0	–	-200,000	–	-0.80%	–
ZYNE	Exit	ZYNERBA PHARMACEUTICALS INC	$0	–	-356,600	–	-0.82%	–
CRIS	Exit	CURIS INC	$0	–	-2,632,000	–	-0.85%	–
RGLS	Exit	REGULUS THERAPEUTICS INC	$0	–	-896,522	–	-0.94%	–
NERV	Exit	MINERVA NEUROSCIENCES INC	$0	–	-1,145,043	–	-0.96%	–
AGEN	Exit	AGENUS INC	$0	–	-1,559,000	–	-1.14%	–
MCRB	Exit	SERES THERAPEUTICS INC	$0	–	-250,000	–	-1.18%	–
LPCN	Exit	LIPOCINE INC NEW	$0	–	-666,666	–	-1.26%	–
FWP	Exit	FORWARD PHARMA A/Ssponsored adr	$0	–	-335,068	–	-1.26%	–
ADXS	Exit	ADVAXIS INC	$0	–	-800,000	–	-1.31%	–
RMTI	Exit	ROCKWELL MED INC	$0	–	-1,105,000	–	-1.36%	–
MRTX	Exit	MIRATI THERAPEUTICS INC	$0	–	-255,000	–	-1.40%	–
PFNX	Exit	PFENEX INC	$0	–	-624,900	–	-1.50%	–
REPH	Exit	RECRO PHARMA INC	$0	–	-780,000	–	-1.50%	–
COLL	Exit	COLLEGIUM PHARMACEUTICAL INC	$0	–	-450,000	–	-1.59%	–
CBPO	Exit	CHINA BIOLOGIC PRODS INC	$0	–	-111,500	–	-1.60%	–
SAGE	Exit	SAGE THERAPEUTICS INC	$0	–	-240,000	–	-1.62%	–
RARE	Exit	ULTRAGENYX PHARMACEUTICAL IN	$0	–	-109,500	–	-1.68%	–
ALNY	Exit	ALNYLAM PHARMACEUTICALS INC	$0	–	-140,000	–	-1.80%	–
NVAX	Exit	NOVAVAX INC	$0	–	-1,600,000	–	-1.81%	–
CHRS	Exit	COHERUS BIOSCIENCES INC	$0	–	-569,130	–	-1.82%	–
TSRO	Exit	TESARO INC	$0	–	-291,250	–	-1.86%	–
BCRX	Exit	BIOCRYST PHARMACEUTICALS	$0	–	-1,080,000	–	-1.97%	–
NVRO	Exit	NEVRO CORP	$0	–	-265,386	–	-1.97%	–
DXCM	Exit	DEXCOM INC	$0	–	-153,000	–	-2.10%	–
DVAX	Exit	DYNAVAX TECHNOLOGIES CORP	$0	–	-575,000	–	-2.25%	–
QTNT	Exit	QUOTIENT LTD	$0	–	-1,119,100	–	-2.32%	–
SRNE	Exit	SORRENTO THERAPEUTICS INC	$0	–	-2,095,334	–	-2.81%	–
PTLA	Exit	PORTOLA PHARMACEUTICALS INC	$0	–	-500,000	–	-3.40%	–
OMER	Exit	OMEROS CORP	$0	–	-1,960,000	–	-3.43%	–
EGRX	Exit	EAGLE PHARMACEUTICALS INC	$0	–	-300,000	–	-3.55%	–
ALDR	Exit	ALDER BIOPHARMACEUTICALS INC	$0	–	-757,475	–	-3.96%	–
ARDX	Exit	ARDELYX INC	$0	–	-1,481,075	–	-4.09%	–
DYAX	Exit	DYAX CORP	$0	–	-1,400,000	–	-4.27%	–
NBIX	Exit	NEUROCRINE BIOSCIENCES INC	$0	–	-718,900	–	-4.57%	–
ALKS	Exit	ALKERMES PLC	$0	–	-700,000	–	-6.56%	–
HRTX	Exit	HERON THERAPEUTICS INC	$0	–	-1,685,719	–	-6.57%	–

Q3 2015

			Value		Shares		↓ Weighting
HRTX	Buy	HERON THERAPEUTICS INC	$41,132,000	-8.3%	1,685,719	+17.1%	6.57%	+10.1%
OMER	Buy	OMEROS CORP	$21,482,000	+207.4%	1,960,000	+404.5%	3.43%	+269.3%
SRNE	Buy	SORRENTO THERAPEUTICS INC	$17,580,000	-48.7%	2,095,334	+7.7%	2.81%	-38.4%
DVAX	Buy	DYNAVAX TECHNOLOGIES CORP	$14,111,000	+20.5%	575,000	+15.0%	2.25%	+44.8%
NVRO	Buy	NEVRO CORP	$12,311,000	+9.9%	265,386	+27.3%	1.97%	+31.9%
BCRX	Buy	BIOCRYST PHARMACEUTICALS	$12,312,000	+21.3%	1,080,000	+58.8%	1.97%	+45.6%
RARE	Buy	ULTRAGENYX PHARMACEUTICAL IN	$10,546,000	+1.0%	109,500	+7.4%	1.68%	+21.2%
SAGE	New	SAGE THERAPEUTICS INC	$10,157,000	–	240,000	–	1.62%	–
MRTX	New	MIRATI THERAPEUTICS INC	$8,777,000	–	255,000	–	1.40%	–
RMTI	Buy	ROCKWELL MED INC	$8,520,000	+55.4%	1,105,000	+225.0%	1.36%	+86.7%
FWP	Buy	FORWARD PHARMA A/Ssponsored adr	$7,894,000	-18.6%	335,068	+31.4%	1.26%	-2.2%
MCRB	Buy	SERES THERAPEUTICS INC	$7,410,000	+257.1%	250,000	+400.0%	1.18%	+329.0%
NERV	Sell	MINERVA NEUROSCIENCES INC	$6,011,000	-9.5%	1,145,043	-0.0%	0.96%	+8.7%
ZYNE	New	ZYNERBA PHARMACEUTICALS INC	$5,103,000	–	356,600	–	0.82%	–
ATRA	Buy	ATARA BIOTHERAPEUTICS INC	$4,716,000	+78.8%	150,000	+200.0%	0.75%	+114.5%
	New	INTEC PHARMA LTD JERUSALEM	$4,480,000	–	800,000	–	0.72%	–
RGNX	New	REGENXBIO INC	$3,453,000	–	156,741	–	0.55%	–
AQXP	Sell	AQUINOX PHARMACEUTICALS INC	$2,111,000	+8.6%	150,000	-46.4%	0.34%	+30.6%
FOLD	Sell	AMICUS THERAPEUTICS INC	$2,099,000	-25.8%	150,000	-25.0%	0.34%	-10.9%
QTNTW	New	QUOTIENT LTD*w exp 10/30/201	$1,630,000	–	500,000	–	0.26%	–
DNAI	New	PRONAI THERAPEUTICS INC	$1,091,000	–	53,153	–	0.17%	–
NEOS	New	NEOS THERAPEUTICS INC	$1,051,000	–	50,000	–	0.17%	–
AKTX	New	AKARI THERAPEUTICS PLCsponsored adr	$687,000	–	28,650	–	0.11%	–
NSTG	Sell	NANOSTRING TECHNOLOGIES INC	$640,000	-48.1%	40,000	-50.0%	0.10%	-37.8%
	New	HERON THERAPEUTICS INC	$100,000	–	5,000	–	0.02%	–
CLTX	Exit	CELSUS THERAPEUTICS PLCsponsored adr ne	$0	–	-286,508	–	-0.02%	–
KERX	Exit	KERYX BIOPHARMACEUTICALS INC	$0	–	-826,000	–	-1.10%	–
RCPT	Exit	RECEPTOS INC	$0	–	-220,000	–	-5.56%	–

Q2 2015

			Value		Shares		↓ Weighting
ALKS	New	ALKERMES PLC	$45,038,000	–	700,000	–	5.99%	–
HRTX	New	HERON THERAPEUTICS INC	$44,870,000	–	1,440,000	–	5.97%	–
RCPT	New	RECEPTOS INC	$41,811,000	–	220,000	–	5.56%	–
ALDR	New	ALDER BIOPHARMACEUTICALS INC	$40,123,000	–	757,475	–	5.33%	–
DYAX	New	DYAX CORP	$37,100,000	–	1,400,000	–	4.93%	–
NBIX	New	NEUROCRINE BIOSCIENCES INC	$34,335,000	–	718,900	–	4.56%	–
SRNE	New	SORRENTO THERAPEUTICS INC	$34,277,000	–	1,945,334	–	4.56%	–
EGRX	New	EAGLE PHARMACEUTICALS INC	$24,258,000	–	300,000	–	3.22%	–
ARDX	New	ARDELYX INC	$23,653,000	–	1,481,075	–	3.14%	–
PTLA	New	PORTOLA PHARMACEUTICALS INC	$22,775,000	–	500,000	–	3.03%	–
NVAX	New	NOVAVAX INC	$17,824,000	–	1,600,000	–	2.37%	–
TSRO	New	TESARO INC	$17,123,000	–	291,250	–	2.28%	–
ALNY	New	ALNYLAM PHARMACEUTICALS INC	$16,782,000	–	140,000	–	2.23%	–
QTNT	New	QUOTIENT LTD	$16,551,000	–	1,119,100	–	2.20%	–
CHRS	New	COHERUS BIOSCIENCES INC	$16,448,000	–	569,130	–	2.19%	–
ADXS	New	ADVAXIS INC	$16,264,000	–	800,000	–	2.16%	–
AGEN	New	AGENUS INC	$13,454,000	–	1,559,000	–	1.79%	–
CBPO	New	CHINA BIOLOGIC PRODS INC	$12,840,000	–	111,500	–	1.71%	–
DXCM	New	DEXCOM INC	$12,237,000	–	153,000	–	1.63%	–
PFNX	New	PFENEX INC	$12,123,000	–	624,900	–	1.61%	–
DVAX	New	DYNAVAX TECHNOLOGIES CORP	$11,713,000	–	500,000	–	1.56%	–
NVRO	New	NEVRO CORP	$11,207,000	–	208,500	–	1.49%	–
RARE	New	ULTRAGENYX PHARMACEUTICAL IN	$10,444,000	–	102,000	–	1.39%	–
BCRX	New	BIOCRYST PHARMACEUTICALS	$10,152,000	–	680,000	–	1.35%	–
REPH	New	RECRO PHARMA INC	$10,078,000	–	780,000	–	1.34%	–
RGLS	New	REGULUS THERAPEUTICS INC	$9,826,000	–	896,522	–	1.31%	–
FWP	New	FORWARD PHARMA A/Ssponsored adr	$9,703,000	–	255,000	–	1.29%	–
CRIS	New	CURIS INC	$8,712,000	–	2,632,000	–	1.16%	–
KERX	New	KERYX BIOPHARMACEUTICALS INC	$8,243,000	–	826,000	–	1.10%	–
KPTI	New	KARYOPHARM THERAPEUTICS INC	$8,190,000	–	300,987	–	1.09%	–
COLL	New	COLLEGIUM PHARMACEUTICAL INC	$8,028,000	–	450,000	–	1.07%	–
OVAS	New	OVASCIENCE INC	$7,296,000	–	252,180	–	0.97%	–
OMER	New	OMEROS CORP	$6,989,000	–	388,500	–	0.93%	–
NERV	New	MINERVA NEUROSCIENCES INC	$6,641,000	–	1,145,053	–	0.88%	–
EPZM	New	EPIZYME INC	$6,390,000	–	266,250	–	0.85%	–
XLRN	New	ACCELERON PHARMA INC	$6,328,000	–	200,000	–	0.84%	–
ARRY	New	ARRAY BIOPHARMA INC	$6,129,000	–	850,000	–	0.82%	–
LPCN	New	LIPOCINE INC NEW	$5,720,000	–	666,666	–	0.76%	–
	New	APTOSE BIOSCIENCES INC	$5,542,000	–	1,081,867	–	0.74%	–
RMTI	New	ROCKWELL MEDICAL INC	$5,481,000	–	340,000	–	0.73%	–
EPRSQ	New	EPIRUS BIOPHARMACEUTICALS IN	$5,120,000	–	896,600	–	0.68%	–
NKTR	New	NEKTAR THERAPEUTICS	$4,973,000	–	397,500	–	0.66%	–
LBIO	New	LION BIOTECHNOLOGIES INC	$4,583,000	–	499,815	–	0.61%	–
KITE	New	KITE PHARMA INC	$4,195,000	–	68,800	–	0.56%	–
SGMO	New	SANGAMO BIOSCIENCES INC	$4,003,000	–	361,000	–	0.53%	–
IMDZ	New	IMMUNE DESIGN CORP	$3,903,000	–	189,000	–	0.52%	–
CYAD	New	CELYAD SAadr	$3,902,000	–	75,000	–	0.52%	–
GLYC	New	GLYCOMIMETICS INC	$3,649,000	–	458,955	–	0.48%	–
ACRX	New	ACELRX PHARMACEUTICALS INC	$3,604,000	–	850,000	–	0.48%	–
DRNA	New	DICERNA PHARMACEUTICALS INC	$3,418,000	–	245,000	–	0.45%	–
DERM	New	DERMIRA INC	$2,984,000	–	170,000	–	0.40%	–
	New	TETRALOGIC PHARMACEUTICAL Cnote 8.000% 6/1	$2,978,000	–	5,000,000	–	0.40%	–
FOLD	New	AMICUS THERAPEUTICS INC	$2,830,000	–	200,000	–	0.38%	–
AVEO	New	AVEO PHARMACEUTICALS INC	$2,763,000	–	1,587,715	–	0.37%	–
BPMC	New	BLUEPRINT MEDICINES CORP	$2,649,000	–	100,000	–	0.35%	–
ATRA	New	ATARA BIOTHERAPEUTICS INC	$2,638,000	–	50,000	–	0.35%	–
VSAR	New	VERSARTIS INC	$2,587,000	–	170,000	–	0.34%	–
CERU	New	CERULEAN PHARMA INC	$2,536,000	–	551,354	–	0.34%	–
GNVC	New	GENVEC INC	$2,400,000	–	1,176,235	–	0.32%	–
KIN	New	KINDRED BIOSCIENCES INC	$2,240,000	–	328,497	–	0.30%	–
HTGM	New	HTG MOLECULAR DIAGNOSTICS IN	$2,241,000	–	201,000	–	0.30%	–
MCRB	New	SERES THERAPEUTICS INC	$2,075,000	–	50,000	–	0.28%	–
AQXP	New	AQUINOX PHARMACEUTICALS INC	$1,943,000	–	279,900	–	0.26%	–
AGRX	New	AGILE THERAPEUTICS INC	$1,564,000	–	182,053	–	0.21%	–
VCYT	New	VERACYTE INC	$1,537,000	–	137,990	–	0.20%	–
CLRB	New	CELLECTAR BIOSCIENCES INC	$1,526,000	–	530,000	–	0.20%	–
NSTG	New	NANOSTRING TECHNOLOGIES INC	$1,234,000	–	80,000	–	0.16%	–
CFRX	New	CONTRAFECT CORP	$1,231,000	–	234,406	–	0.16%	–
PVCT	New	PROVECTUS BIOPHARMACEUTICALS	$1,188,000	–	2,200,000	–	0.16%	–
ASND	New	ASCENDIS PHARMA A Sspnsored adr	$1,087,000	–	61,500	–	0.14%	–
AKBA	New	AKEBIA THERAPEUTICS INC	$1,032,000	–	100,300	–	0.14%	–
BITI	New	BIOTIE THERAPIES OYJsponsored adr	$999,000	–	50,000	–	0.13%	–
SCYX	New	SCYNEXIS INC	$873,000	–	99,366	–	0.12%	–
GALT	New	GALECTIN THERAPEUTICS INC	$781,000	–	286,200	–	0.10%	–
PVCTW	New	PROVECTUS BIOPHARMACEUTICALS*w exp 06/24/202	$480,000	–	2,200,000	–	0.06%	–
ADAP	New	ADAPTIMMUNE THERAPEUTICS PLCsponds adr	$458,000	–	25,000	–	0.06%	–
CLRBW	New	CELLECTAR BIOSCIENCES INC*w exp 08/19/201	$413,000	–	530,000	–	0.06%	–
CLLS	New	CELLECTIS S Asponsored ads	$408,000	–	11,300	–	0.05%	–
AGTC	New	APPLIED GENETIC TECHNOL CORP	$262,000	–	17,110	–	0.04%	–
CLTX	New	CELSUS THERAPEUTICS PLCsponsored adr ne	$166,000	–	286,508	–	0.02%	–

Q4 2014

			Value		Shares		↓ Weighting
CLRBW	Exit	CELLECTAR BIOSCIENCES INC*w exp 08/19/201	$0	–	-530,000	–	-0.06%	–
SAGE	Exit	SAGE THERAPEUTICS INC	$0	–	-10,000	–	-0.06%	–
SCYX	Exit	SCYNEXIS INC	$0	–	-100,000	–	-0.15%	–
CRIS	Exit	CURIS INC	$0	–	-600,000	–	-0.17%	–
	Exit	BRISTOL MYERS SQUIBB CO	$0	–	-5,000	–	-0.20%	–
NERV	Exit	MINERVA NEUROSCIENCES INC	$0	–	-175,000	–	-0.22%	–
AGRX	Exit	AGILE THERAPEUTICS INC	$0	–	-150,000	–	-0.22%	–
AGTC	Exit	APPLIED GENETIC TECHNOL CORP	$0	–	-60,600	–	-0.23%	–
CLRB	Exit	CELLECTAR BIOSCIENCES INC	$0	–	-530,000	–	-0.24%	–
ADXS	Exit	ADVAXIS INC	$0	–	-350,000	–	-0.24%	–
RGLS	Exit	REGULUS THERAPEUTICS INC	$0	–	-200,000	–	-0.28%	–
CLTX	Exit	CELSUS THERAPEUTICS PLCsponsored adr ne	$0	–	-244,500	–	-0.31%	–
ALDR	Exit	ALDER BIOPHARMACEUTICALS INC	$0	–	-150,000	–	-0.39%	–
CERU	Exit	CERULEAN PHARMA INC	$0	–	-450,000	–	-0.39%	–
ZSPH	Exit	ZS PHARMA INC	$0	–	-50,000	–	-0.40%	–
AQXP	Exit	AQUINOX PHARMACEUTICALS INC	$0	–	-300,000	–	-0.41%	–
AGEN	Exit	AGENUS INC	$0	–	-650,000	–	-0.42%	–
REPH	Exit	RECRO PHARMA INC	$0	–	-700,000	–	-0.43%	–
AAVL	Exit	AVALANCHE BIOTECHNOLOGIES IN	$0	–	-65,000	–	-0.46%	–
GALT	Exit	GALECTIN THERAPEUTICS INC	$0	–	-450,400	–	-0.47%	–
ASPX	Exit	AUSPEX PHARMACEUTICALS INC	$0	–	-100,000	–	-0.53%	–
GNVC	Exit	GENVEC INC	$0	–	-1,329,300	–	-0.57%	–
KITE	Exit	KITE PHARMA INC	$0	–	-100,000	–	-0.59%	–
CLVS	Exit	CLOVIS ONCOLOGY INC	$0	–	-70,000	–	-0.65%	–
KIN	Exit	KINDRED BIOSCIENCES INC	$0	–	-350,000	–	-0.67%	–
GLYC	Exit	GLYCOMIMETICS INC	$0	–	-472,300	–	-0.67%	–
NSTG	Exit	NANOSTRING TECHNOLOGIES INC	$0	–	-300,000	–	-0.68%	–
IMDZ	Exit	IMMUNE DESIGN CORP	$0	–	-200,000	–	-0.73%	–
ARRY	Exit	ARRAY BIOPHARMA INC	$0	–	-1,000,000	–	-0.73%	–
RMTI	Exit	ROCKWELL MED INC	$0	–	-400,000	–	-0.75%	–
VSAR	Exit	VERSARTIS INC	$0	–	-200,000	–	-0.78%	–
ALNY	Exit	ALNYLAM PHARMACEUTICALS INC	$0	–	-50,000	–	-0.80%	–
ALKS	Exit	ALKERMES PLC	$0	–	-100,000	–	-0.88%	–
SRNE	Exit	SORRENTO THERAPEUTICS INC	$0	–	-1,000,000	–	-0.93%	–
QTNT	Exit	QUOTIENT LTD	$0	–	-500,000	–	-0.97%	–
PTLA	Exit	PORTOLA PHARMACEUTICALS INC	$0	–	-200,000	–	-1.04%	–
EGRX	Exit	EAGLE PHARMACEUTICALS INC	$0	–	-400,000	–	-1.04%	–
CBPO	Exit	CHINA BIOLOGIC PRODS INC	$0	–	-95,000	–	-1.05%	–
SGMO	Exit	SANGAMO BIOSCIENCES INC	$0	–	-500,000	–	-1.11%	–
NKTR	Exit	NEKTAR THERAPEUTICS	$0	–	-450,000	–	-1.12%	–
ACRX	Exit	ACELRX PHARMACEUTICALS INC	$0	–	-1,000,000	–	-1.13%	–
PTCT	Exit	PTC THERAPEUTICS INC	$0	–	-125,000	–	-1.13%	–
ARDX	Exit	ARDELYX INC	$0	–	-388,700	–	-1.14%	–
HRTX	Exit	HERON THERAPEUTICS INC	$0	–	-700,000	–	-1.20%	–
AGIO	Exit	AGIOS PHARMACEUTICALS INC	$0	–	-100,000	–	-1.26%	–
NVAX	Exit	NOVAVAX INC	$0	–	-1,500,000	–	-1.29%	–
RARE	Exit	ULTRAGENYX PHARMACEUTICAL INC	$0	–	-120,000	–	-1.40%	–
GEVA	Exit	SYNAGEVA BIOPHARMA CORP	$0	–	-100,000	–	-1.42%	–
CMRX	Exit	CHIMERIX INC	$0	–	-250,000	–	-1.42%	–
OMER	Exit	OMEROS CORP	$0	–	-547,900	–	-1.43%	–
BMY	Exit	BRISTOL MYERS SQUIBB CO	$0	–	-150,000	–	-1.58%	–
DXCM	Exit	DEXCOM INC	$0	–	-200,000	–	-1.64%	–
TSRO	Exit	TESARO INC	$0	–	-300,000	–	-1.66%	–
OVAS	Exit	OVASCIENCE INC	$0	–	-516,200	–	-1.76%	–
AKBA	Exit	AKEBIA THERAPEUTICS INC	$0	–	-400,000	–	-1.82%	–
BCRX	Exit	BIOCRYST PHARMACEUTICALS INC	$0	–	-1,100,000	–	-2.21%	–
XLRN	Exit	ACCELERON PHARMA INC	$0	–	-400,000	–	-2.49%	–
ARWR	Exit	ARROWHEAD RESH CORP	$0	–	-900,000	–	-2.73%	–
NBIX	Exit	NEUROCRINE BIOSCIENCES INC	$0	–	-850,000	–	-2.74%	–
KPTI	Exit	KARYOPHARM THERAPEUTICS INC	$0	–	-385,000	–	-2.77%	–
KERX	Exit	KERYX BIOPHARMACEUTICALS	$0	–	-1,000,000	–	-2.83%	–
DYAX	Exit	DYAX CORP	$0	–	-1,500,000	–	-3.12%	–
JAZZ	Exit	JAZZ PHARMACEUTICALS PLC	$0	–	-100,000	–	-3.30%	–
RCPT	Exit	RECEPTOS INC	$0	–	-748,700	–	-9.56%	–
PBYI	Exit	PUMA BIOTECHNOLOGY INC	$0	–	-507,500	–	-24.90%	–

Q3 2014

			Value		Shares		↓ Weighting
PBYI	Buy	PUMA BIOTECHNOLOGY INC	$121,074,000	+784.1%	507,500	+144.6%	24.90%	+586.2%
RCPT	Buy	RECEPTOS INC	$46,502,000	+128.0%	748,700	+56.4%	9.56%	+77.0%
DYAX	Sell	DYAX CORP	$15,180,000	-12.2%	1,500,000	-16.7%	3.12%	-31.8%
KERX	New	KERYX BIOPHARMACEUTICALS	$13,750,000	–	1,000,000	–	2.83%	–
NBIX	Buy	NEUROCRINE BIOSCIENCES INC	$13,320,000	+199.3%	850,000	+183.3%	2.74%	+132.4%
XLRN	Buy	ACCELERON PHARMA INC	$12,096,000	+78.0%	400,000	+100.0%	2.49%	+38.2%
BCRX	Sell	BIOCRYST PHARMACEUTICALS INC	$10,758,000	-27.8%	1,100,000	-5.8%	2.21%	-43.9%
OVAS	New	OVASCIENCE INC	$8,569,000	–	516,200	–	1.76%	–
BMY	New	BRISTOL MYERS SQUIBB CO	$7,677,000	–	150,000	–	1.58%	–
OMER	Sell	OMEROS CORP	$6,969,000	-64.3%	547,900	-51.2%	1.43%	-72.3%
CMRX	Sell	CHIMERIX INC	$6,905,000	+4.9%	250,000	-16.7%	1.42%	-18.6%
GEVA	New	SYNAGEVA BIOPHARMA CORP	$6,878,000	–	100,000	–	1.42%	–
AGIO	New	AGIOS PHARMACEUTICALS INC	$6,135,000	–	100,000	–	1.26%	–
ARDX	New	ARDELYX INC	$5,523,000	–	388,700	–	1.14%	–
PTCT	Sell	PTC THERAPEUTICS INC	$5,501,000	+40.3%	125,000	-16.7%	1.13%	+8.9%
ACRX	Buy	ACELRX PHARMACEUTICALS INC	$5,490,000	-23.5%	1,000,000	+42.9%	1.13%	-40.6%
NKTR	New	NEKTAR THERAPEUTICS	$5,432,000	–	450,000	–	1.12%	–
CBPO	Sell	CHINA BIOLOGIC PRODS INC	$5,126,000	+15.3%	95,000	-5.0%	1.05%	-10.5%
IMDZ	New	IMMUNE DESIGN CORP	$3,532,000	–	200,000	–	0.73%	–
KIN	Buy	KINDRED BIOSCIENCES INC	$3,238,000	+73.7%	350,000	+250.0%	0.67%	+34.8%
KITE	New	KITE PHARMA INC	$2,850,000	–	100,000	–	0.59%	–
GALT	Sell	GALECTIN THERAPEUTICS INC	$2,266,000	-79.5%	450,400	-43.7%	0.47%	-84.1%
AAVL	New	AVALANCHE BIOTECHNOLOGIES IN	$2,222,000	–	65,000	–	0.46%	–
REPH	Buy	RECRO PHARMA INC	$2,072,000	-48.3%	700,000	+40.0%	0.43%	-59.8%
AGEN	Sell	AGENUS INC	$2,022,000	-30.2%	650,000	-27.8%	0.42%	-45.8%
ZSPH	New	ZS PHARMA INC	$1,962,000	–	50,000	–	0.40%	–
CLTX	Buy	CELSUS THERAPEUTICS PLCsponsored adr ne	$1,491,000	+133.3%	244,500	+137.4%	0.31%	+81.7%
CLRB	New	CELLECTAR BIOSCIENCES INC	$1,177,000	–	530,000	–	0.24%	–
ADXS	New	ADVAXIS INC	$1,176,000	–	350,000	–	0.24%	–
AGTC	Sell	APPLIED GENETIC TECHNOL CORP	$1,128,000	-77.7%	60,600	-72.3%	0.23%	-82.7%
NERV	New	MINERVA NEUROSCIENCES INC	$1,059,000	–	175,000	–	0.22%	–
	New	BRISTOL MYERS SQUIBB CO	$985,000	–	5,000	–	0.20%	–
CLRBW	New	CELLECTAR BIOSCIENCES INC*w exp 08/19/201	$318,000	–	530,000	–	0.06%	–
SAGE	New	SAGE THERAPEUTICS INC	$315,000	–	10,000	–	0.06%	–
ACAD	Exit	ACADIA PHARMACEUTICALS INC	$0	–	-50,000	–	-0.30%	–
	Exit	PUMA BIOTECHNOLOGY INC	$0	–	-5,000	–	-1.19%	–
MRK	Exit	MERCK & CO INC NEW	$0	–	-100,000	–	-1.53%	–
MNKKQ	Exit	MALLINCKRODT PUB LTD CO	$0	–	-90,000	–	-1.91%	–
CELG	Exit	CELGENE CORP	$0	–	-200,000	–	-4.55%	–
QCOR	Exit	QUESTCOR PHARMACEUTICALS INC	$0	–	-200,000	–	-4.90%	–

Q2 2014

			Value		Shares		↓ Weighting
RCPT	New	RECEPTOS INC	$20,397,000	–	478,800	–	5.40%	–
OMER	New	OMEROS CORP	$19,540,000	–	1,123,000	–	5.18%	–
QCOR	New	QUESTCOR PHARMACEUTICALS INC	$18,498,000	–	200,000	–	4.90%	–
KPTI	New	KARYOPHARM THERAPEUTICS INC	$17,922,000	–	385,000	–	4.75%	–
DYAX	New	DYAX CORP	$17,280,000	–	1,800,000	–	4.58%	–
CELG	New	CELGENE CORP	$17,176,000	–	200,000	–	4.55%	–
BCRX	New	BIOCRYST PHARMACEUTICALS	$14,892,000	–	1,168,000	–	3.95%	–
JAZZ	New	JAZZ PHARMACEUTICALS PLC	$14,701,000	–	100,000	–	3.90%	–
PBYI	New	PUMA BIOTECHNOLOGY INC	$13,695,000	–	207,500	–	3.63%	–
ARWR	New	ARROWHEAD RESH CORP	$12,879,000	–	900,000	–	3.41%	–
AKBA	New	AKEBIA THERAPEUTICS INC	$11,116,000	–	400,000	–	2.95%	–
GALT	New	GALECTIN THERAPEUTICS INC	$11,048,000	–	800,000	–	2.93%	–
TSRO	New	TESARO INC	$9,333,000	–	300,000	–	2.47%	–
HRTX	New	HERON THERAPEUTICS INC	$8,624,000	–	700,000	–	2.28%	–
DXCM	New	DEXCOM INC	$7,932,000	–	200,000	–	2.10%	–
SGMO	New	SANGAMO BIOSCIENCES INC	$7,635,000	–	500,000	–	2.02%	–
MNKKQ	New	MALLINCKRODT PUB LTD CO	$7,202,000	–	90,000	–	1.91%	–
ACRX	New	ACELRX PHARMACEUTICALS INC	$7,175,000	–	700,000	–	1.90%	–
NVAX	New	NOVAVAX INC	$6,930,000	–	1,500,000	–	1.84%	–
XLRN	New	ACCELERON PHARMA INC	$6,794,000	–	200,000	–	1.80%	–
SRNE	New	SORRENTO THERAPEUTICS INC	$6,750,000	–	1,000,000	–	1.79%	–
CMRX	New	CHIMERIX INC	$6,582,000	–	300,000	–	1.74%	–
PTLA	New	PORTOLA PHARMACEUTICALS INC	$5,836,000	–	200,000	–	1.55%	–
MRK	New	MERCK & CO INC NEW	$5,785,000	–	100,000	–	1.53%	–
EGRX	New	EAGLE PHARMACEUTICALS INC	$5,732,000	–	400,000	–	1.52%	–
VSAR	New	VERSARTIS INC	$5,608,000	–	200,000	–	1.49%	–
RARE	New	ULTRAGENYX PHARMACEUTICAL INC	$5,387,000	–	120,000	–	1.43%	–
AGTC	New	APPLIED GENETIC TECHNOLOGIES	$5,050,000	–	218,600	–	1.34%	–
ALKS	New	ALKERMES PLC	$5,033,000	–	100,000	–	1.33%	–
RMTI	New	ROCKWELL MED INC	$4,796,000	–	400,000	–	1.27%	–
ARRY	New	ARRAY BIOPHARMA INC	$4,560,000	–	1,000,000	–	1.21%	–
	New	PUMA BIOTECHNOLOGY INC	$4,500,000	–	5,000	–	1.19%	–
NSTG	New	NANOSTRING TECHNOLOGIES INC	$4,485,000	–	300,000	–	1.19%	–
NBIX	New	NEUROCRINE BIOSCIENCES INC	$4,451,000	–	300,000	–	1.18%	–
CBPO	New	CHINA BIOLOGIC PRODS INC	$4,447,000	–	100,000	–	1.18%	–
QTNT	New	QUOTIENT LTD	$4,180,000	–	500,000	–	1.11%	–
REPH	New	RECRO PHARMA INC	$4,005,000	–	500,000	–	1.06%	–
GLYC	New	GLYCOMIMETICS INC	$3,981,000	–	472,300	–	1.06%	–
PTCT	New	PTC THERAPEUTICS INC	$3,921,000	–	150,000	–	1.04%	–
GNVC	New	GENVEC INC	$3,416,000	–	1,329,300	–	0.90%	–
ALNY	New	ALNYLAM PHARMACEUTICALS INC	$3,159,000	–	50,000	–	0.84%	–
ALDR	New	ALDER BIOPHARMACEUTICALS INC	$3,011,000	–	150,000	–	0.80%	–
CLVS	New	CLOVIS ONCOLOGY INC	$2,899,000	–	70,000	–	0.77%	–
AGEN	New	AGENUS INC	$2,898,000	–	900,000	–	0.77%	–
AQXP	New	AQUINOX PHARMACEUTICALS INC	$2,829,000	–	300,000	–	0.75%	–
CERU	New	CERULEAN PHARMA INC	$2,610,000	–	450,000	–	0.69%	–
ASPX	New	AUSPEX PHARMACEUTICALS INC	$2,227,000	–	100,000	–	0.59%	–
KIN	New	KINDRED BIOSCIENCES INC	$1,864,000	–	100,000	–	0.49%	–
RGLS	New	REGULUS THERAPEUTICS INC	$1,608,000	–	200,000	–	0.43%	–
AGRX	New	AGILE THERAPEUTICS INC	$1,308,000	–	150,000	–	0.35%	–
ACAD	New	ACADIA PHARMACEUTICALS INC	$1,130,000	–	50,000	–	0.30%	–
CRIS	New	CURIS INC	$1,116,000	–	600,000	–	0.30%	–
SCYX	New	SCYNEXIS INC	$802,000	–	100,000	–	0.21%	–
CLTX	New	CELSUS THERAPEUTICS PLCsponsored adr ne	$639,000	–	103,000	–	0.17%	–

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