ACUTA CAPITAL PARTNERS, LLC Activity Q4 2014-Q3 2023

Q3 2023

			Value		Shares		↓ Weighting
TSHA	New	TAYSHA GENE THERAPIES INC	$12,096,246	–	3,827,926	–	8.11%	–
APLS	Sell	APELLIS PHARMACEUTICALS INC	$9,300,171	-65.7%	244,484	-17.8%	6.23%	-66.1%
PRAX	Buy	PRAXIS PRECISION MEDICINES I	$7,669,350	+56.9%	4,485,000	+5.5%	5.14%	+55.2%
	New	RAYZEBIO INC	$7,649,476	–	344,571	–	5.13%	–
SRPT	New	SAREPTA THERAPEUTICS INCcall	$7,580,650	–	550	–	5.08%	–
RCKT	Buy	ROCKET PHARMACEUTICALS INC	$7,417,380	+21.9%	362,000	+18.2%	4.97%	+20.6%
	Buy	VENTYX BIOSCIENCES INC	$7,132,743	+47.6%	205,377	+39.4%	4.78%	+46.0%
	Sell	DISC MEDICINE INC	$6,492,542	+4.8%	138,198	-0.9%	4.35%	+3.7%
KURA	Sell	KURA ONCOLOGY INC.	$6,403,088	-14.7%	702,093	-1.0%	4.29%	-15.6%
CBAY	Sell	CYMABAY THERAPEUTICS INC	$6,232,380	+32.4%	418,000	-2.8%	4.18%	+30.9%
PCVX	Sell	VAXCYTE INC	$6,169,702	+1.1%	121,022	-0.9%	4.14%	+0.0%
IMVT	Sell	IMMUNOVANT INC	$4,952,310	+84.2%	129,000	-9.0%	3.32%	+82.2%
SNDX	Sell	SYNDAX PHARMACEUTICALS INC	$4,312,948	-31.3%	297,035	-0.9%	2.89%	-32.0%
	Buy	HILLEVAX INC	$3,635,791	+235.3%	270,319	+328.5%	2.44%	+231.6%
ALKS	Buy	ALKERMES PLC	$3,543,265	+153.3%	126,500	+183.1%	2.38%	+150.5%
VRDN	Sell	VIRIDIAN THERAPEUTICS INC	$3,441,360	-35.6%	224,339	-0.2%	2.31%	-36.3%
CLDX	Sell	CELLDEX THERAPEUTICS INC	$3,366,824	-18.9%	122,341	-0.0%	2.26%	-19.8%
CRNX	New	CRINETICS PHARMACEUTICALS INC	$2,795,560	–	94,000	–	1.87%	–
TERN	Sell	TERNS PHARMACEUTICALS INC	$2,792,958	-67.1%	555,260	-42.8%	1.87%	-67.4%
REPL	New	REPLIMUNE GROUP INC	$2,566,500	–	150,000	–	1.72%	–
EYPT	Sell	EYEPOINT PHARMACEUTICALS INC	$2,398,023	-27.8%	300,128	-21.4%	1.61%	-28.6%
IKNA	Sell	IKENA ONCOLOGY INC	$2,385,873	-34.8%	551,010	-1.3%	1.60%	-35.5%
CNTA	New	CENTESSA PHARMACEUTICALS PLCsponsored ads	$2,092,068	–	323,349	–	1.40%	–
OLMA	Buy	OLEMA PHARMACEUTICALS INC	$1,889,636	+97.8%	153,007	+44.6%	1.27%	+95.7%
SRPT	New	SAREPTA THERAPEUTICS INC	$1,878,910	–	15,500	–	1.26%	–
	Sell	VERASTEM INC	$1,869,900	-16.2%	230,000	-23.3%	1.25%	-17.1%
REPL	New	REPLIMUNE GROUP INCcall	$1,766,000	–	1,000	–	1.18%	–
ETNB	New	89BIO INCcall	$1,523,000	–	1,000	–	1.02%	–
	Sell	ENLIVEN THERAPEUTICS INC	$1,415,176	-33.6%	103,600	-0.9%	0.95%	-34.4%
DYN	Buy	DYNE THERAPEUTICS INC	$1,312,640	+59.8%	146,500	+100.7%	0.88%	+58.3%
KRON	Buy	KRONOS BIO INC	$934,361	+72.5%	718,739	+128.2%	0.63%	+70.6%
BCLI	New	BRAINSTORM CELL THERAPEUTICSput	$825,000	–	2,500	–	0.55%	–
BMEA	Sell	BIOMEA FUSION INC	$549,506	-37.4%	39,935	-0.2%	0.37%	-38.2%
IONS	New	IONIS PHARMACEUTICALS INC	$512,568	–	11,300	–	0.34%	–
ETNB	New	89BIO INC	$506,432	–	32,800	–	0.34%	–
	New	LEAP THERAPEUTICS INC	$488,749	–	354,166	–	0.33%	–
RZLT	Sell	REZOLUTE INC	$409,200	-44.7%	310,000	-17.0%	0.27%	-45.3%
	New	CELLECTAR BIOSCIENCES INC.	$320,232	–	121,300	–	0.22%	–
	New	STRUCTURE THERAPEUTICS INCsponsored ads	$252,100	–	5,000	–	0.17%	–
	New	AN2 THERAPEUTICS INC	$213,864	–	13,300	–	0.14%	–
	New	MARINUS PHARMECEUTICALS INC	$156,975	–	19,500	–	0.10%	–
MRSN	New	MERSANA THERAPEUTICS INC	$126,501	–	99,607	–	0.08%	–
GLYC	New	GLYCOMIMETIC INC	$41,250	–	27,500	–	0.03%	–
SVRA	Exit	SAVARA INC	$0	–	-198,139	–	-0.43%	–
ARWR	Exit	ARROWHEAD PHARMACEUTICALS INC	$0	–	-27,500	–	-0.66%	–
MORF	Exit	MORPHIC HOLDING INC	$0	–	-17,500	–	-0.68%	–
	Exit	ROIVANT SCIENCES LTDshares	$0	–	-220,000	–	-1.50%	–
GHRS	Exit	GH RESEARCH PLCordinary shares	$0	–	-244,828	–	-1.97%	–
CLNN	Exit	CLENE INC	$0	–	-4,240,846	–	-2.53%	–
ARGX	Exit	ARGENX SEsponsored adr	$0	–	-12,568	–	-3.32%	–
ISEE	Exit	IVERIC BIO INC	$0	–	-131,454	–	-3.50%	–

Q2 2023

			Value		Shares		↓ Weighting
APLS	New	APELLIS PHARMACEUTICALS INC	$27,110,996	–	297,596	–	18.37%	–
	New	AADI BIOSCIENCES INC	$12,649,910	–	1,849,402	–	8.57%	–
TERN	New	TERNS PHARMACEUTICALS INC	$8,487,500	–	970,000	–	5.75%	–
KURA	New	KURA ONCOLOGY INC. COMMON STOCK	$7,502,468	–	709,118	–	5.08%	–
SNDX	New	SYNDAX PHARMACEUTICALS INC	$6,275,672	–	299,841	–	4.25%	–
	New	DISC MEDICINE INC	$6,193,800	–	139,500	–	4.20%	–
PCVX	New	VAXCYTE INC	$6,100,970	–	122,166	–	4.13%	–
RCKT	New	ROCKET PHARMACEUTICALS INC	$6,084,075	–	306,194	–	4.12%	–
VRDN	New	VIRIDIAN THERAPEUTICS INC	$5,345,780	–	224,707	–	3.62%	–
ISEE	New	IVERIC BIO INC	$5,171,400	–	131,454	–	3.50%	–
ARGX	New	ARGENX SEsponsored adr	$4,898,127	–	12,568	–	3.32%	–
PRAX	New	PRAXIS PRECISION MEDICINES I	$4,887,500	–	4,250,000	–	3.31%	–
	New	VENTYX BIOSCIENCES INC	$4,832,030	–	147,318	–	3.27%	–
CBAY	New	CYMABAY THERAPEUTICS INC. COMMON STOCK	$4,708,500	–	430,000	–	3.19%	–
CLDX	New	CELLDEX THERAPEUTICS INC	$4,151,098	–	122,343	–	2.81%	–
CLNN	New	CLENE INC	$3,731,520	–	4,240,846	–	2.53%	–
IKNA	New	IKENA ONCOLOGY INC	$3,660,480	–	558,000	–	2.48%	–
EYPT	New	EYEPOINT PHARMACEUTICALS INC	$3,323,400	–	382,000	–	2.25%	–
GHRS	New	GH RESEARCH PLCordinary shares	$2,904,884	–	244,828	–	1.97%	–
IMVT	New	IMMUNOVANT INC	$2,689,092	–	141,755	–	1.82%	–
	New	VERASTEM INC	$2,232,000	–	300,000	–	1.51%	–
	New	ROIVANT SCIENCES LTDshares	$2,217,600	–	220,000	–	1.50%	–
	New	ENLIVEN THERAPEUTICS INC	$2,132,845	–	104,500	–	1.44%	–
ALKS	New	ALKERMES PLC	$1,398,766	–	44,689	–	0.95%	–
ACRS	New	ACLARIS THERAPEUTICS	$1,261,946	–	121,692	–	0.86%	–
	New	HILLEVAX INC	$1,084,311	–	63,078	–	0.74%	–
MORF	New	MORPHIC HOLDING INC	$1,003,275	–	17,500	–	0.68%	–
ARWR	New	ARROWHEAD PHARMACEUTICALS INC	$980,650	–	27,500	–	0.66%	–
OLMA	New	OLEMA PHARMACEUTICALS INC	$955,500	–	105,814	–	0.65%	–
BMEA	New	BIOMEA FUSION INC	$878,000	–	40,000	–	0.60%	–
DYN	New	DYNE THERAPEUTICS INC	$821,250	–	73,000	–	0.56%	–
RZLT	New	REZOLUTE INC	$739,332	–	373,400	–	0.50%	–
SVRA	New	SAVARA INC	$633,054	–	198,139	–	0.43%	–
KRON	New	KRONOS BIO INC	$541,800	–	315,000	–	0.37%	–
NUVBWS	New	NUVATION BIO INC*w exp 07/07/2027	$15,023	–	90,832	–	0.01%	–

Q4 2022

			Value		Shares		↓ Weighting
BMEA	Exit	BIOMEA FUSION INC	$0	–	-1,000	–	-0.00%	–
NUVBWS	Exit	NUVATION BIO INC*w exp 07/07/2027	$0	–	-90,832	–	-0.01%	–
TRVI	Exit	TREVI THERAPEUTICS INC	$0	–	-36,302	–	-0.02%	–
KNTE	Exit	KINNATE BIOPHARMA INC	$0	–	-5,000	–	-0.03%	–
NGM	Exit	NGM BIOPHARMACEUTICALS INC	$0	–	-7,500	–	-0.04%	–
ZNTL	Exit	ZENTALIS PHARMACEUTICALS INC	$0	–	-5,000	–	-0.05%	–
	Exit	DICE THERAPEUTICS INC	$0	–	-6,700	–	-0.06%	–
SWTX	Exit	SPRINGWORKS THERAPEUTICS INC	$0	–	-5,000	–	-0.06%	–
IDYA	Exit	IDEAYA BIOSCIENCES INC	$0	–	-10,000	–	-0.06%	–
ESPR	Exit	ESPERION THERAPEUTIC	$0	–	-30,000	–	-0.09%	–
HZNP	Exit	HORIZON THERAPEUTICS PLC	$0	–	-4,000	–	-0.11%	–
IMGN	Exit	IMMUNOGEN INC	$0	–	-140,000	–	-0.29%	–
RZLT	Exit	REZOLUTE INC	$0	–	-419,145	–	-0.49%	–
ALLK	Exit	ALLAKOS INC	$0	–	-192,500	–	-0.51%	–
MRUS	Exit	MERUS BV	$0	–	-59,000	–	-0.51%	–
	Exit	PYXIS ONCOLOGY INC	$0	–	-669,158	–	-0.57%	–
IOVA	Exit	IOVANCE BIOTHERAPEUTICS INC	$0	–	-153,639	–	-0.63%	–
ALT	Exit	ALTIMMUNE INC	$0	–	-125,000	–	-0.69%	–
FULC	Exit	FULCRUM THERAPEUTICS INC	$0	–	-220,000	–	-0.77%	–
PMVP	Exit	PMV PHARMACEUTICALS INC	$0	–	-154,500	–	-0.79%	–
PCVX	Exit	VAXCYTE INC	$0	–	-85,000	–	-0.88%	–
TERN	Exit	TERNS PHARMACEUTICALS INC	$0	–	-350,702	–	-0.89%	–
EYPT	Exit	EYEPOINT PHARMACEUTICALS INC	$0	–	-303,396	–	-1.03%	–
ACRS	Exit	ACLARIS THERAPEU	$0	–	-160,835	–	-1.09%	–
GHRS	Exit	GH RESEARCH PLCordinary shares	$0	–	-243,250	–	-1.22%	–
ARWR	Exit	ARROWHEAD PHARMACEUTICALS INC	$0	–	-87,500	–	-1.24%	–
FOLD	Exit	AMICUS THERAPEUTICS INC	$0	–	-290,000	–	-1.30%	–
GOSS	Exit	GOSSAMER BIO INC	$0	–	-284,500	–	-1.47%	–
BCAB	Exit	BIOATLA INC	$0	–	-520,000	–	-1.72%	–
SRPT	Exit	SAREPTA TEHRAPEUTICS INC	$0	–	-41,500	–	-1.98%	–
MIST	Exit	MILESTONE PHARMACEUTICALS IN	$0	–	-597,026	–	-2.36%	–
JYAC	Exit	JIYA ACQUISITION CORP -CL A	$0	–	-562,500	–	-2.42%	–
UTHR	Exit	UNITED THERAPEUTICS CORP DEL	$0	–	-27,500	–	-2.48%	–
	Exit	VENTYX BIOSCIENCES INC	$0	–	-180,000	–	-2.71%	–
MRTX	Exit	MIRATI THERAPEUTICS	$0	–	-104,800	–	-3.15%	–
KURA	Exit	KURA ONCOLOGY INC. COMMON STOCK	$0	–	-536,500	–	-3.16%	–
RLMD	Exit	RELMADA THERAPEUTICS INCput	$0	–	-200,000	–	-3.19%	–
VRDN	Exit	VIRIDIAN THERAPEUTICS INC	$0	–	-362,735	–	-3.20%	–
CLDX	Exit	CELLDEX THERAPEUTICS INC	$0	–	-267,195	–	-3.23%	–
SNDX	Exit	SYNDAX PHARMACEUTICALS INC	$0	–	-324,614	–	-3.36%	–
BLSA	Exit	BCLS ACQUISITION CORP- CL A	$0	–	-843,122	–	-3.64%	–
XENE	Exit	XENON PHARMACEUTICALS INC	$0	–	-272,500	–	-4.24%	–
ISEE	Exit	IVERIC BIO INC	$0	–	-563,607	–	-4.35%	–
RLMD	Exit	RELMADA THERAPEUTICS INC	$0	–	-365,618	–	-5.83%	–
BLU	Exit	BELLUS HEALTH INC	$0	–	-1,438,500	–	-6.54%	–
	Exit	AADI BIOSCIENCES INC	$0	–	-1,849,402	–	-11.25%	–
APLS	Exit	APELLIS PHARMACEUTICALS INC	$0	–	-554,000	–	-16.29%	–

Q3 2022

			Value		Shares		↓ Weighting
	Buy	AADI BIOSCIENCES INC	$26,132,000	+38.7%	1,849,402	+20.9%	11.25%	+7.2%
BLU	Buy	BELLUS HEALTH INC	$15,191,000	+101.5%	1,438,500	+76.3%	6.54%	+55.7%
RLMD	Buy	RELMADA THERAPEUTICS INC	$13,535,000	+102.2%	365,618	+3.7%	5.83%	+56.3%
SNDX	Buy	SYNDAX PHARMACEUTICALS INC	$7,800,000	+97.8%	324,614	+58.3%	3.36%	+52.9%
VRDN	Buy	VIRIDIAN THERAPEUTICS INC	$7,440,000	+174.7%	362,735	+55.0%	3.20%	+112.3%
RLMD	New	RELMADA THERAPEUTICS INCput	$7,404,000	–	200,000	–	3.19%	–
MRTX	Buy	MIRATI THERAPEUTICS	$7,319,000	+15.4%	104,800	+10.9%	3.15%	-10.8%
	Buy	VENTYX BIOSCIENCES INC	$6,284,000	+321.2%	180,000	+47.5%	2.71%	+225.6%
UTHR	Buy	UNITED THERAPEUTICS CORP DEL	$5,758,000	+88.0%	27,500	+111.5%	2.48%	+45.4%
MIST	Buy	MILESTONE PHARMACEUTICALS IN	$5,487,000	+95.1%	597,026	+30.6%	2.36%	+50.8%
SRPT	New	SAREPTA TEHRAPEUTICS INC	$4,587,000	–	41,500	–	1.98%	–
BCAB	New	BIOATLA INC	$4,004,000	–	520,000	–	1.72%	–
GOSS	Buy	GOSSAMER BIO INC	$3,408,000	+1171.6%	284,500	+789.1%	1.47%	+885.2%
FOLD	New	AMICUS THERAPEUTICS INC	$3,028,000	–	290,000	–	1.30%	–
ARWR	Buy	ARROWHEAD PHARMACEUTICALS INC	$2,892,000	+32.7%	87,500	+41.3%	1.24%	+2.6%
ACRS	Sell	ACLARIS THERAPEU	$2,532,000	-5.9%	160,835	-16.6%	1.09%	-27.3%
TERN	New	TERNS PHARMACEUTICALS INC	$2,066,000	–	350,702	–	0.89%	–
PCVX	New	VAXCYTE INC	$2,040,000	–	85,000	–	0.88%	–
PMVP	Buy	PMV PHARMACEUTICALS INC	$1,839,000	-15.4%	154,500	+1.3%	0.79%	-34.6%
FULC	Buy	FULCRUM THERAPEUTICS INC	$1,780,000	+81.6%	220,000	+10.0%	0.77%	+40.5%
ALT	New	ALTIMMUNE INC	$1,596,000	–	125,000	–	0.69%	–
IOVA	Sell	IOVANCE BIOTHERAPEUTICS INC	$1,472,000	-13.6%	153,639	-0.5%	0.63%	-33.2%
	Buy	PYXIS ONCOLOGY INC	$1,318,000	-14.1%	669,158	+3.7%	0.57%	-33.6%
MRUS	Sell	MERUS BV	$1,182,000	-66.1%	59,000	-61.7%	0.51%	-73.8%
ALLK	New	ALLAKOS INC	$1,178,000	–	192,500	–	0.51%	–
RZLT	Sell	REZOLUTE INC	$1,148,000	-44.9%	419,145	-35.0%	0.49%	-57.5%
IMGN	New	IMMUNOGEN INC	$669,000	–	140,000	–	0.29%	–
HZNP	Sell	HORIZON THERAPEUTICS PLC	$248,000	-91.3%	4,000	-88.9%	0.11%	-93.3%
ESPR	New	ESPERION THERAPEUTIC	$201,000	–	30,000	–	0.09%	–
IDYA	New	IDEAYA BIOSCIENCES INC	$149,000	–	10,000	–	0.06%	–
	New	DICE THERAPEUTICS INC	$136,000	–	6,700	–	0.06%	–
ZNTL	New	ZENTALIS PHARMACEUTICALS INC	$108,000	–	5,000	–	0.05%	–
NGM	New	NGM BIOPHARMACEUTICALS INC	$98,000	–	7,500	–	0.04%	–
KNTE	New	KINNATE BIOPHARMA INC	$60,000	–	5,000	–	0.03%	–
TRVI	Buy	TREVI THERAPEUTICS INC	$56,000	-42.9%	36,302	+3.7%	0.02%	-56.4%
BMEA	New	BIOMEA FUSION INC	$10,000	–	1,000	–	0.00%	–
OCUL	Exit	OCULAR THERAPEUTIX INC	$0	–	-13,171	–	-0.03%	–
VSTM	Exit	VERASTEM INC	$0	–	-200,000	–	-0.13%	–
	Exit	ATHIRA PHARMA INCcall	$0	–	-100,000	–	-0.19%	–
	Exit	AC IMMUNE SAcall	$0	–	-100,000	–	-0.20%	–
ACAD	Exit	ACADIA PHARMACEUTICALS INC	$0	–	-71,500	–	-0.56%	–
ITOS	Exit	ITEOS THERAPEUTICS INC	$0	–	-62,000	–	-0.71%	–
ENTA	Exit	ENANTA PHARMACEUTICALS INC	$0	–	-27,500	–	-0.72%	–
DTIL	Exit	PRECISION BIOSCIENCES INC	$0	–	-2,050,359	–	-1.83%	–
HSAQ	Exit	HEALTH SCIENCES ACQUISITIONS	$0	–	-392,500	–	-2.18%	–
RCUS	Exit	ARCUS BIOSCIENCES INC	$0	–	-167,500	–	-2.36%	–
	Exit	ROCHE GS	$0	–	-16,000	–	-2.97%	–
VTGN	Exit	VISTAGEN THERAPEUTICS INC	$0	–	-11,361,451	–	-5.57%	–

Q2 2022

			Value		Shares		↓ Weighting
APLS	New	APELLIS PHARMACEUTICALS INC	$25,052,000	–	554,000	–	13.96%	–
	New	AADI BIOSCIENCES INC	$18,842,000	–	1,529,402	–	10.50%	–
VTGN	New	VISTAGEN THERAPEUTICS INC	$9,998,000	–	11,361,451	–	5.57%	–
KURA	New	KURA ONCOLOGY INC. COMMON STOCK	$9,834,000	–	536,500	–	5.48%	–
BLSA	New	BCLS ACQUISITION CORP- CL A	$8,347,000	–	843,122	–	4.65%	–
XENE	New	XENON PHARMACEUTICALS INC	$8,289,000	–	272,500	–	4.62%	–
BLU	New	BELLUS HEALTH INC	$7,540,000	–	816,000	–	4.20%	–
CLDX	New	CELLDEX THERAPEUTICS INC	$7,204,000	–	267,195	–	4.01%	–
RLMD	New	RELMADA THERAPEUTICS INC	$6,694,000	–	352,500	–	3.73%	–
MRTX	New	MIRATI THERAPEUTICS	$6,344,000	–	94,500	–	3.53%	–
JYAC	New	JIYA ACQUISITION CORP -CL A	$5,552,000	–	562,500	–	3.09%	–
ISEE	New	IVERIC BIO INC	$5,422,000	–	563,607	–	3.02%	–
	New	ROCHE GS	$5,338,000	–	16,000	–	2.97%	–
RCUS	New	ARCUS BIOSCIENCES INC	$4,244,000	–	167,500	–	2.36%	–
SNDX	New	SYNDAX PHARMACEUTICALS INC	$3,944,000	–	205,003	–	2.20%	–
HSAQ	New	HEALTH SCIENCES ACQUISITIONS	$3,909,000	–	392,500	–	2.18%	–
MRUS	New	MERUS BV	$3,487,000	–	154,000	–	1.94%	–
DTIL	New	PRECISION BIOSCIENCES INC	$3,281,000	–	2,050,359	–	1.83%	–
UTHR	New	UNITED THERAPEUTICS CORP DEL	$3,063,000	–	13,000	–	1.71%	–
HZNP	New	HORIZON THERAPEUTICS PLC	$2,862,000	–	35,888	–	1.59%	–
MIST	New	MILESTONE PHARMACEUTICALS IN	$2,812,000	–	457,200	–	1.57%	–
VRDN	New	VIRIDIAN THERAPEUTICS INC	$2,708,000	–	234,026	–	1.51%	–
ACRS	New	ACLARIS THERAPEU	$2,692,000	–	192,835	–	1.50%	–
GHRS	New	GH RESEARCH PLCordinary shares	$2,428,000	–	243,250	–	1.35%	–
EYPT	New	EYEPOINT PHARMACEUTICALS INC	$2,388,000	–	303,396	–	1.33%	–
ARWR	New	ARROWHEAD PHARMACEUTICALS INC	$2,180,000	–	61,926	–	1.21%	–
PMVP	New	PMV PHARMACEUTICALS INC	$2,173,000	–	152,500	–	1.21%	–
RZLT	New	REZOLUTE INC	$2,084,000	–	645,136	–	1.16%	–
IOVA	New	IOVANCE BIOTHERAPEUTICS INC	$1,704,000	–	154,356	–	0.95%	–
	New	PYXIS ONCOLOGY INC	$1,535,000	–	645,149	–	0.86%	–
	New	VENTYX BIOSCIENCES INC	$1,492,000	–	122,000	–	0.83%	–
ENTA	New	ENANTA PHARMACEUTICALS INC	$1,300,000	–	27,500	–	0.72%	–
ITOS	New	ITEOS THERAPEUTICS INC	$1,277,000	–	62,000	–	0.71%	–
ACAD	New	ACADIA PHARMACEUTICALS INC	$1,007,000	–	71,500	–	0.56%	–
FULC	New	FULCRUM THERAPEUTICS INC	$980,000	–	200,000	–	0.55%	–
	New	AC IMMUNE SAcall	$354,000	–	100,000	–	0.20%	–
	New	ATHIRA PHARMA INCcall	$340,000	–	100,000	–	0.19%	–
GOSS	New	GOSSAMER BIO INC	$268,000	–	32,000	–	0.15%	–
VSTM	New	VERASTEM INC	$232,000	–	200,000	–	0.13%	–
SWTX	New	SPRINGWORKS THERAPEUTICS INC	$123,000	–	5,000	–	0.07%	–
TRVI	New	TREVI THERAPEUTICS INC	$98,000	–	35,000	–	0.06%	–
OCUL	New	OCULAR THERAPEUTIX INC	$53,000	–	13,171	–	0.03%	–
NUVBWS	New	NUVATION BIO INC*w exp 07/07/202	$25,000	–	90,832	–	0.01%	–

Q4 2021

			Value		Shares		↓ Weighting
NUVBWS	Exit	NUVATION BIO INC*w exp 07/07/202	$0	–	-90,832	–	-0.08%	–
NVAX	Exit	NOVAVAX INC	$0	–	-2,315	–	-0.17%	–
UTHR	Exit	UNITED THERAPEUTICS DEL	$0	–	-3,000	–	-0.20%	–
ELAN	Exit	ELANCO ANIMAL HEALTH	$0	–	-29,000	–	-0.33%	–
CCCC	Exit	C4 THERAPEUTICS STK	$0	–	-21,000	–	-0.33%	–
CBAY	Exit	CYMABAY THERAPEUTICS INC	$0	–	-301,904	–	-0.39%	–
CMRX	Exit	CHIMERIX	$0	–	-210,000	–	-0.46%	–
	Exit	ASTRIA THERAPEUTICS	$0	–	-156,927	–	-0.49%	–
RNA	Exit	AVIDITY BIOSCIENCES INC	$0	–	-60,000	–	-0.52%	–
CBIO	Exit	CATALYST BIOSCIENCES INC	$0	–	-365,000	–	-0.53%	–
BCYC	Exit	BICYCLE THERAPEUTICS PLC SPONSORED ADSsponsored ads	$0	–	-38,184	–	-0.56%	–
ALT	Exit	ALTIMMUNE	$0	–	-150,000	–	-0.60%	–
RETA	Exit	REATA PHARMACEUTICALS INCcl a	$0	–	-17,500	–	-0.62%	–
ALLK	Exit	ALLAKOS	$0	–	-17,500	–	-0.65%	–
VRDN	Exit	VIRIDIAN THERAPEUTICS	$0	–	-135,807	–	-0.79%	–
AVDL	Exit	AVADEL PHARMACEUTICALS PLCcall	$0	–	-250,000	–	-0.86%	–
APLS	Exit	APELLIS PHARMACEUTICALS INC	$0	–	-75,500	–	-0.88%	–
ACRS	Exit	ACLARIS THERAPEUTICS INC	$0	–	-140,839	–	-0.89%	–
MRUS	Exit	MERUS N V	$0	–	-122,000	–	-0.95%	–
GOSS	Exit	GOSSAMER BIO	$0	–	-215,000	–	-0.95%	–
RAIN	Exit	RAIN THERAPEUTICS INC	$0	–	-182,500	–	-0.96%	–
ATHA	Exit	ATHIRA PHARMA INC	$0	–	-297,362	–	-0.98%	–
CABA	Exit	CABALETTA BIO	$0	–	-302,926	–	-1.30%	–
KRYS	Exit	KRYSTAL BIOTECH	$0	–	-72,551	–	-1.34%	–
EYPT	Exit	EYEPOINT PHARMACEUTICALS INC	$0	–	-369,863	–	-1.36%	–
HSAQ	Exit	HEALTH SCIENCES ACQ CORP 2	$0	–	-392,500	–	-1.37%	–
SNDX	Exit	SYNDAX PHARMACEUTICALS INC	$0	–	-206,126	–	-1.39%	–
OLMA	Exit	OLEMA PHARMACEUTICALS	$0	–	-150,500	–	-1.46%	–
VINC	Exit	VINCERX PHARMA INC	$0	–	-260,000	–	-1.48%	–
SELB	Exit	SELECTA BIOSCIENCES INC	$0	–	-1,024,668	–	-1.50%	–
KURA	Exit	KURA ONCOLOGY INC	$0	–	-291,884	–	-1.93%	–
JYAC	Exit	JIYA ACQUISITION CORP	$0	–	-562,500	–	-1.94%	–
VSTM	Exit	VERASTEM INC	$0	–	-2,018,433	–	-2.19%	–
XENE	Exit	XENON PHARMACEUTICALS INC	$0	–	-417,409	–	-2.25%	–
CYT	Exit	CYTEIR THERAPEUTICS INC	$0	–	-391,974	–	-2.43%	–
SEEL	Exit	SEELOS THERAPEUTICS INC	$0	–	-2,860,000	–	-2.43%	–
ARWR	Exit	ARROWHEAD PHARMACEUTICALS IN	$0	–	-121,500	–	-2.68%	–
CLSD	Exit	CLEARSIDE BIOMEDICAL INC	$0	–	-1,316,268	–	-2.79%	–
BLSA	Exit	BCLS ACQUISITION CORP	$0	–	-843,122	–	-2.96%	–
GHRS	Exit	GH RESEARCH PLCordinary shares	$0	–	-393,250	–	-3.06%	–
FULC	Exit	FULCRUM THERAPEUTICS INC	$0	–	-322,500	–	-3.21%	–
IOVA	Exit	IOVANCE BIOTHERAPEUTICS INC	$0	–	-374,495	–	-3.26%	–
BLU	Exit	BELLUS HEALTH	$0	–	-2,007,500	–	-4.35%	–
CLDX	Exit	CELLDEX THERAPEUTICS INC NEW	$0	–	-337,500	–	-6.43%	–
ISEE	Exit	IVERIC BIO INC	$0	–	-1,135,000	–	-6.50%	–
VTGN	Exit	VISTAGEN THERAPEUTICS INC	$0	–	-11,728,033	–	-11.34%	–
	Exit	AADI BIOSCIENCE	$0	–	-1,529,402	–	-15.85%	–

Q3 2021

			Value		Shares		↓ Weighting
	New	AADI BIOSCIENCE	$44,919,000	–	1,529,402	–	15.85%	–
ISEE	Sell	IVERIC BIO INC	$18,432,000	+133.7%	1,135,000	-9.2%	6.50%	+106.3%
CLDX	Sell	CELLDEX THERAPEUTICS INC NEW	$18,222,000	-44.8%	337,500	-65.8%	6.43%	-51.3%
BLU	New	BELLUS HEALTH	$12,326,000	–	2,007,500	–	4.35%	–
IOVA	Buy	IOVANCE BIOTHERAPEUTICS INC	$9,235,000	+137.4%	374,495	+150.5%	3.26%	+109.5%
FULC	Sell	FULCRUM THERAPEUTICS INC	$9,098,000	+43.7%	322,500	-46.6%	3.21%	+26.9%
GHRS	Buy	GH RESEARCH PLCordinary shares	$8,675,000	+166.1%	393,250	+162.2%	3.06%	+134.9%
ARWR	Buy	ARROWHEAD PHARMACEUTICALS IN	$7,585,000	-15.2%	121,500	+12.5%	2.68%	-25.1%
CYT	Buy	CYTEIR THERAPEUTICS INC	$6,879,000	+15.7%	391,974	+41.1%	2.43%	+2.2%
KURA	Sell	KURA ONCOLOGY INC	$5,467,000	-25.8%	291,884	-17.4%	1.93%	-34.5%
VINC	Sell	VINCERX PHARMA INC	$4,204,000	-32.3%	260,000	-45.7%	1.48%	-40.3%
OLMA	New	OLEMA PHARMACEUTICALS	$4,148,000	–	150,500	–	1.46%	–
KRYS	New	KRYSTAL BIOTECH	$3,788,000	–	72,551	–	1.34%	–
CABA	New	CABALETTA BIO	$3,684,000	–	302,926	–	1.30%	–
ATHA	Sell	ATHIRA PHARMA INC	$2,789,000	-36.2%	297,362	-30.4%	0.98%	-43.7%
RAIN	Buy	RAIN THERAPEUTICS INC	$2,730,000	+8.3%	182,500	+12.5%	0.96%	-4.4%
GOSS	New	GOSSAMER BIO	$2,703,000	–	215,000	–	0.95%	–
MRUS	New	MERUS N V	$2,684,000	–	122,000	–	0.95%	–
ACRS	Sell	ACLARIS THERAPEUTICS INC	$2,535,000	-17.5%	140,839	-19.5%	0.89%	-27.2%
APLS	Sell	APELLIS PHARMACEUTICALS INC	$2,488,000	-75.5%	75,500	-53.0%	0.88%	-78.3%
AVDL	New	AVADEL PHARMACEUTICALS PLCcall	$2,450,000	–	250,000	–	0.86%	–
VRDN	New	VIRIDIAN THERAPEUTICS	$2,234,000	–	135,807	–	0.79%	–
ALLK	New	ALLAKOS	$1,853,000	–	17,500	–	0.65%	–
RETA	Buy	REATA PHARMACEUTICALS INCcl a	$1,761,000	+24.5%	17,500	+75.0%	0.62%	+9.9%
ALT	New	ALTIMMUNE	$1,697,000	–	150,000	–	0.60%	–
BCYC	New	BICYCLE THERAPEUTICS PLC SPONSORED ADSsponsored ads	$1,588,000	–	38,184	–	0.56%	–
CBIO	Sell	CATALYST BIOSCIENCES INC	$1,500,000	-49.4%	365,000	-46.7%	0.53%	-55.4%
	New	ASTRIA THERAPEUTICS	$1,387,000	–	156,927	–	0.49%	–
CMRX	Sell	CHIMERIX	$1,300,000	-68.1%	210,000	-58.8%	0.46%	-71.8%
CCCC	New	C4 THERAPEUTICS STK	$938,000	–	21,000	–	0.33%	–
ELAN	New	ELANCO ANIMAL HEALTH	$925,000	–	29,000	–	0.33%	–
UTHR	New	UNITED THERAPEUTICS DEL	$554,000	–	3,000	–	0.20%	–
CPRX	Exit	CATALYST PHARMACEUTICALS INC	$0	–	-329,134	–	-0.76%	–
	Exit	CATABASIS PHARMACEUTICALS IN	$0	–	-1,173,674	–	-0.99%	–
SAGE	Exit	SAGE THERAPEUTICS INC	$0	–	-50,945	–	-1.16%	–
AVDL	Exit	AVADEL PHARMACEUTICALS PLCsponsored adr	$0	–	-561,011	–	-1.51%	–
ALGS	Exit	ALIGOS THERAPEUTICS INC	$0	–	-214,254	–	-1.75%	–
EPIX	Exit	ESSA PHARMA INC	$0	–	-232,896	–	-2.66%	–
CLDX	Exit	CELLDEX THERAPEUTICS INC NEWput	$0	–	-500,000	–	-6.68%	–

Q2 2021

			Value		Shares		↓ Weighting
VTGN	New	VISTAGEN THERAPEUTICS INC	$36,943,000	–	11,728,033	–	14.76%	–
CLDX	New	CELLDEX THERAPEUTICS INC NEW	$33,019,000	–	987,406	–	13.20%	–
CLDX	New	CELLDEX THERAPEUTICS INC NEWput	$16,720,000	–	500,000	–	6.68%	–
APLS	New	APELLIS PHARMACEUTICALS INC	$10,144,000	–	160,500	–	4.05%	–
ARWR	New	ARROWHEAD PHARMACEUTICALS IN	$8,945,000	–	108,000	–	3.58%	–
BLSA	New	BCLS ACQUISITION CORP	$8,878,000	–	843,122	–	3.55%	–
VSTM	New	VERASTEM INC	$8,215,000	–	2,018,433	–	3.28%	–
ISEE	New	IVERIC BIO INC	$7,888,000	–	1,250,000	–	3.15%	–
XENE	New	XENON PHARMACEUTICALS INC	$7,772,000	–	417,409	–	3.11%	–
SEEL	New	SEELOS THERAPEUTICS INC	$7,550,000	–	2,860,000	–	3.02%	–
KURA	New	KURA ONCOLOGY INC	$7,368,000	–	353,398	–	2.94%	–
EPIX	New	ESSA PHARMA INC	$6,654,000	–	232,896	–	2.66%	–
CLSD	New	CLEARSIDE BIOMEDICAL INC	$6,410,000	–	1,316,268	–	2.56%	–
FULC	New	FULCRUM THERAPEUTICS INC	$6,331,000	–	604,074	–	2.53%	–
VINC	New	VINCERX PHARMA INC	$6,214,000	–	478,401	–	2.48%	–
CYT	New	CYTEIR THERAPEUTICS INC	$5,944,000	–	277,777	–	2.38%	–
JYAC	New	JIYA ACQUISITION CORP	$5,591,000	–	562,500	–	2.23%	–
ATHA	New	ATHIRA PHARMA INC	$4,373,000	–	427,060	–	1.75%	–
ALGS	New	ALIGOS THERAPEUTICS INC	$4,368,000	–	214,254	–	1.75%	–
SELB	New	SELECTA BIOSCIENCES INC	$4,283,000	–	1,024,668	–	1.71%	–
CMRX	New	CHIMERIX INC	$4,073,000	–	509,164	–	1.63%	–
HSAQ	New	HEALTH SCIENCES ACQ CORP 2	$4,004,000	–	392,500	–	1.60%	–
IOVA	New	IOVANCE BIOTHERAPEUTICS INC	$3,890,000	–	149,495	–	1.56%	–
AVDL	New	AVADEL PHARMACEUTICALS PLCsponsored adr	$3,776,000	–	561,011	–	1.51%	–
SNDX	New	SYNDAX PHARMACEUTICALS INC	$3,539,000	–	206,126	–	1.41%	–
EYPT	New	EYEPOINT PHARMACEUTICALS INC	$3,325,000	–	369,863	–	1.33%	–
GHRS	New	GH RESEARCH PLCordinary shares	$3,260,000	–	150,000	–	1.30%	–
ACRS	New	ACLARIS THERAPEUTICS INC	$3,073,000	–	175,000	–	1.23%	–
CBIO	New	CATALYST BIOSCIENCES INC	$2,966,000	–	685,000	–	1.18%	–
SAGE	New	SAGE THERAPEUTICS INC	$2,894,000	–	50,945	–	1.16%	–
RAIN	New	RAIN THERAPEUTICS INC	$2,521,000	–	162,245	–	1.01%	–
	New	CATABASIS PHARMACEUTICALS IN	$2,476,000	–	1,173,674	–	0.99%	–
CPRX	New	CATALYST PHARMACEUTICALS INC	$1,893,000	–	329,134	–	0.76%	–
RNA	New	AVIDITY BIOSCIENCES INC	$1,483,000	–	60,000	–	0.59%	–
RETA	New	REATA PHARMACEUTICALS INCcl a	$1,415,000	–	10,000	–	0.56%	–
CBAY	New	CYMABAY THERAPEUTICS INC	$1,316,000	–	301,904	–	0.53%	–
NVAX	New	NOVAVAX INC	$491,000	–	2,315	–	0.20%	–
NUVBWS	New	NUVATION BIO INC*w exp 07/07/202	$236,000	–	90,832	–	0.09%	–

Q4 2020

			Value		Shares		↓ Weighting
WVE	Exit	WAVE LIFE SCIENCES LTD	$0	–	-107,500	–	-0.25%	–
CLSD	Exit	CLEARSIDE BIOMEDICAL INC	$0	–	-615,000	–	-0.26%	–
UMRX	Exit	UNUM THERAPEUTICS INC	$0	–	-410,000	–	-0.26%	–
KRTX	Exit	KARUNA THERAPEUTICS INC	$0	–	-13,500	–	-0.28%	–
AXSM	Exit	AXSOME THERAPEUTICS INC	$0	–	-22,500	–	-0.44%	–
BCRX	Exit	BIOCRYST PHARMACEUTICALS	$0	–	-660,000	–	-0.62%	–
VSTM	Exit	VERASTEM INC	$0	–	-2,400,000	–	-0.79%	–
CNCE	Exit	CONCERT PHARMACEUTICALS INC	$0	–	-300,000	–	-0.80%	–
FULC	Exit	FULCRUM THERAPEUTICS INC	$0	–	-381,500	–	-0.82%	–
XENE	Exit	XENON PHARMACEUTICALS INC	$0	–	-300,000	–	-0.90%	–
ANNX	Exit	ANNEXON INC	$0	–	-110,000	–	-0.90%	–
PANAU	Exit	PANACEA ACQUISITION CORPunit 99/99/9999	$0	–	-280,000	–	-0.91%	–
AVDL	Exit	AVADEL PHARMACEUTICALS PLCsponsored adr	$0	–	-705,218	–	-0.96%	–
SNDX	Exit	SYNDAX PHARMACEUTICALS INC	$0	–	-240,744	–	-0.96%	–
HSAQ	Exit	HEALTH SCIENCES ACQ CORP 2	$0	–	-392,500	–	-1.17%	–
CRDF	Exit	CARDIFF ONCOLOGY INC	$0	–	-305,900	–	-1.18%	–
ARWR	Exit	ARROWHEAD PHARMACEUTICALS IN	$0	–	-101,500	–	-1.19%	–
ISEE	Exit	IVERIC BIO INC	$0	–	-802,500	–	-1.23%	–
APLS	Exit	APELLIS PHARMACEUTICALS INC	$0	–	-167,054	–	-1.37%	–
CBAY	Exit	CYMABAY THERAPEUTICS INC	$0	–	-765,000	–	-1.50%	–
SELB	Exit	SELECTA BIOSCIENCES INC	$0	–	-2,364,204	–	-1.59%	–
CBIO	Exit	CATALYST BIOSCIENCES INC	$0	–	-1,497,900	–	-1.75%	–
RNA	Exit	AVIDITY BIOSCIENCES INC	$0	–	-235,000	–	-1.80%	–
ATHA	Exit	ATHIRA PHARMA INC	$0	–	-362,500	–	-1.82%	–
SURF	Exit	SURFACE ONCOLOGY INC	$0	–	-1,088,000	–	-2.04%	–
LSACU	Exit	LIFESCI ACQUISITION CORPunit 03/31/2025	$0	–	-560,000	–	-2.07%	–
RAPT	Exit	RAPT THERAPEUTICS INC	$0	–	-240,000	–	-2.10%	–
CYTK	Exit	CYTOKINETICS INC	$0	–	-357,500	–	-2.10%	–
IMVT	Exit	IMMUNOVANT INC	$0	–	-250,000	–	-2.39%	–
ALT	Exit	ALTIMMUNE INC	$0	–	-688,000	–	-2.47%	–
IOVA	Exit	IOVANCE BIOTHERAPEUTICS INC	$0	–	-315,000	–	-2.82%	–
RLMD	Exit	RELMADA THERAPEUTICS INC	$0	–	-277,000	–	-2.83%	–
ETNB	Exit	89BIO INC	$0	–	-417,500	–	-2.91%	–
	Exit	TRILLIUM THERAPEUTICS INC	$0	–	-853,000	–	-3.29%	–
ALDX	Exit	ALDEYRA THERAPEUTICS INC	$0	–	-1,646,700	–	-3.31%	–
MRSN	Exit	MERSANA THERAPEUTICS INC	$0	–	-667,500	–	-3.38%	–
LRMR	Exit	LARIMAR THERAPEUTICS INC	$0	–	-830,000	–	-3.42%	–
CMPS	Exit	COMPASS PATHWAYS PLCsponsored ads	$0	–	-390,000	–	-3.70%	–
SAGE	Exit	SAGE THERAPEUTICS INC	$0	–	-225,000	–	-3.74%	–
CLDX	Exit	CELLDEX THERAPEUTICS INC NEW	$0	–	-1,545,000	–	-6.22%	–
XBI	Exit	SPDR SER TRput	$0	–	-250,000	–	-7.57%	–
KURA	Exit	KURA ONCOLOGY INC	$0	–	-973,000	–	-8.10%	–
IMMU	Exit	IMMUNOMEDICS INC	$0	–	-511,500	–	-11.81%	–

Q3 2020

			Value		Shares		↓ Weighting
IMMU	Sell	IMMUNOMEDICS INC	$43,493,000	+125.2%	511,500	-6.1%	11.81%	+111.6%
KURA	Buy	KURA ONCOLOGY INC	$29,813,000	+109.6%	973,000	+11.5%	8.10%	+97.0%
XBI	New	SPDR SER TRput	$27,858,000	–	250,000	–	7.57%	–
CLDX	Buy	CELLDEX THERAPEUTICS INC NEW	$22,912,000	+76.2%	1,545,000	+54.5%	6.22%	+65.7%
SAGE	New	SAGE THERAPEUTICS INC	$13,752,000	–	225,000	–	3.74%	–
CMPS	New	COMPASS PATHWAYS PLCsponsored ads	$13,611,000	–	390,000	–	3.70%	–
LRMR	Buy	LARIMAR THERAPEUTICS INC	$12,591,000	+22.6%	830,000	+0.8%	3.42%	+15.2%
MRSN	Buy	MERSANA THERAPEUTICS INC	$12,429,000	-16.0%	667,500	+5.5%	3.38%	-21.1%
ALDX	Buy	ALDEYRA THERAPEUTICS INC	$12,202,000	+228.8%	1,646,700	+85.0%	3.31%	+209.1%
	New	TRILLIUM THERAPEUTICS INC	$12,121,000	–	853,000	–	3.29%	–
ETNB	New	89BIO INC	$10,713,000	–	417,500	–	2.91%	–
RLMD	Buy	RELMADA THERAPEUTICS INC	$10,421,000	-0.7%	277,000	+18.1%	2.83%	-6.7%
IOVA	Sell	IOVANCE BIOTHERAPEUTICS INC	$10,370,000	-36.0%	315,000	-46.6%	2.82%	-39.8%
ALT	Buy	ALTIMMUNE INC	$9,082,000	+57.8%	688,000	+28.0%	2.47%	+48.3%
IMVT	Sell	IMMUNOVANT INC	$8,798,000	+3.2%	250,000	-28.6%	2.39%	-3.0%
CYTK	New	CYTOKINETICS INC	$7,740,000	–	357,500	–	2.10%	–
RAPT	New	RAPT THERAPEUTICS INC	$7,728,000	–	240,000	–	2.10%	–
SURF	Buy	SURFACE ONCOLOGY INC	$7,507,000	+408.6%	1,088,000	+383.6%	2.04%	+378.6%
ATHA	New	ATHIRA PHARMA INC	$6,692,000	–	362,500	–	1.82%	–
RNA	Buy	AVIDITY BIOSCIENCES INC	$6,615,000	+99.2%	235,000	+100.0%	1.80%	+87.1%
CBAY	New	CYMABAY THERAPEUTICS INC	$5,539,000	–	765,000	–	1.50%	–
APLS	Sell	APELLIS PHARMACEUTICALS INC	$5,040,000	-18.8%	167,054	-12.1%	1.37%	-23.6%
ISEE	Buy	IVERIC BIO INC	$4,526,000	+29.1%	802,500	+16.7%	1.23%	+21.3%
ARWR	Buy	ARROWHEAD PHARMACEUTICALS IN	$4,371,000	+68.7%	101,500	+69.2%	1.19%	+58.5%
CRDF	Sell	CARDIFF ONCOLOGY INC	$4,341,000	+112.6%	305,900	-24.9%	1.18%	+99.8%
HSAQ	New	HEALTH SCIENCES ACQ CORP 2	$4,318,000	–	392,500	–	1.17%	–
AVDL	Sell	AVADEL PHARMACEUTICALS PLCsponsored adr	$3,554,000	-74.9%	705,218	-59.8%	0.96%	-76.4%
PANAU	New	PANACEA ACQUISITION CORPunit 99/99/9999	$3,360,000	–	280,000	–	0.91%	–
ANNX	New	ANNEXON INC	$3,325,000	–	110,000	–	0.90%	–
XENE	Sell	XENON PHARMACEUTICALS INC	$3,321,000	-48.8%	300,000	-42.0%	0.90%	-51.9%
FULC	New	FULCRUM THERAPEUTICS INC	$3,025,000	–	381,500	–	0.82%	–
CNCE	New	CONCERT PHARMACEUTICALS INC	$2,946,000	–	300,000	–	0.80%	–
VSTM	Sell	VERASTEM INC	$2,904,000	-36.3%	2,400,000	-9.4%	0.79%	-40.1%
BCRX	Sell	BIOCRYST PHARMACEUTICALS	$2,267,000	-75.0%	660,000	-65.3%	0.62%	-76.5%
AXSM	Sell	AXSOME THERAPEUTICS INC	$1,603,000	-78.4%	22,500	-75.0%	0.44%	-79.7%
KRTX	Sell	KARUNA THERAPEUTICS INC	$1,044,000	-88.0%	13,500	-82.7%	0.28%	-88.7%
UMRX	New	UNUM THERAPEUTICS INC	$959,000	–	410,000	–	0.26%	–
CLSD	New	CLEARSIDE BIOMEDICAL INC	$947,000	–	615,000	–	0.26%	–
AKUS	Exit	AKOUOS INC	$0	–	-22,200	–	-0.14%	–
STSA	Exit	SATSUMA PHARMACEUTICALS INC	$0	–	-35,000	–	-0.29%	–
GBIO	Exit	GENERATION BIO CO	$0	–	-100,000	–	-0.61%	–
FUSN	Exit	FUSION PHARMACEUTICALS INC	$0	–	-135,000	–	-0.68%	–
RETA	Exit	REATA PHARMACEUTICALS INCcl a	$0	–	-15,300	–	-0.69%	–
QURE	Exit	UNIQURE NV	$0	–	-60,000	–	-0.78%	–
EIGR	Exit	EIGER BIOPHARMACEUTICALS INC	$0	–	-292,500	–	-0.81%	–
AGEN	Exit	AGENUS INC	$0	–	-932,500	–	-1.06%	–
ARVN	Exit	ARVINAS INC	$0	–	-123,000	–	-1.19%	–
DRNA	Exit	DICERNA PHARMACEUTICALS INC	$0	–	-170,000	–	-1.25%	–
VIR	Exit	VIR BIOTECHNOLOGY INC	$0	–	-127,000	–	-1.50%	–
KDMN	Exit	KADMON HLDGS INC	$0	–	-1,280,000	–	-1.89%	–
APLT	Exit	APPLIED THERAPEUTICS INC	$0	–	-182,000	–	-1.90%	–
MRUS	Exit	MERUS N V	$0	–	-460,000	–	-2.14%	–
BLU	Exit	BELLUS HEALTH INC NEW	$0	–	-765,000	–	-2.27%	–
ASND	Exit	ASCENDIS PHARMA A Ssponsored adr	$0	–	-55,500	–	-2.37%	–
ADAP	Exit	ADAPTIMMUNE THERAPEUTICS PLCsponds adr	$0	–	-1,165,000	–	-3.37%	–
BTAI	Exit	BIOXCEL THERAPEUTICS INC	$0	–	-340,500	–	-5.22%	–
ADVM	Exit	ADVERUM BIOTECHNOLOGIES INC	$0	–	-1,746,500	–	-10.54%	–

Q2 2020

			Value		Shares		↓ Weighting
ADVM	New	ADVERUM BIOTECHNOLOGIES INC	$36,467,000	–	1,746,500	–	10.54%	–
IMMU	New	IMMUNOMEDICS INC	$19,315,000	–	545,000	–	5.58%	–
BTAI	New	BIOXCEL THERAPEUTICS INC	$18,050,000	–	340,500	–	5.22%	–
IOVA	New	IOVANCE BIOTHERAPEUTICS INC	$16,196,000	–	590,000	–	4.68%	–
MRSN	New	MERSANA THERAPEUTICS INC	$14,801,000	–	632,500	–	4.28%	–
KURA	New	KURA ONCOLOGY INC	$14,222,000	–	872,500	–	4.11%	–
AVDL	New	AVADEL PHARMACEUTICALS PLCsponsored adr	$14,158,000	–	1,752,218	–	4.09%	–
CLDX	New	CELLDEX THERAPEUTICS INC NEW	$13,000,000	–	1,000,000	–	3.76%	–
ADAP	New	ADAPTIMMUNE THERAPEUTICS PLCsponds adr	$11,662,000	–	1,165,000	–	3.37%	–
RLMD	New	RELMADA THERAPEUTICS INC	$10,494,000	–	234,500	–	3.03%	–
LRMR	New	LARIMAR THERAPEUTICS INC	$10,272,000	–	823,169	–	2.97%	–
BCRX	New	BIOCRYST PHARMACEUTICALS	$9,054,000	–	1,900,000	–	2.62%	–
CBIO	New	CATALYST BIOSCIENCES INC	$8,793,000	–	1,497,900	–	2.54%	–
KRTX	New	KARUNA THERAPEUTICS INC	$8,694,000	–	78,000	–	2.51%	–
IMVT	New	IMMUNOVANT INC	$8,523,000	–	350,000	–	2.46%	–
ASND	New	ASCENDIS PHARMA A Ssponsored adr	$8,208,000	–	55,500	–	2.37%	–
BLU	New	BELLUS HEALTH INC NEW	$7,872,000	–	765,000	–	2.27%	–
AXSM	New	AXSOME THERAPEUTICS INC	$7,405,000	–	90,000	–	2.14%	–
MRUS	New	MERUS N V	$7,401,000	–	460,000	–	2.14%	–
SELB	New	SELECTA BIOSCIENCES INC	$6,714,000	–	2,364,204	–	1.94%	–
APLT	New	APPLIED THERAPEUTICS INC	$6,579,000	–	182,000	–	1.90%	–
KDMN	New	KADMON HLDGS INC	$6,554,000	–	1,280,000	–	1.89%	–
XENE	New	XENON PHARMACEUTICALS INC	$6,489,000	–	517,500	–	1.88%	–
APLS	New	APELLIS PHARMACEUTICALS INC	$6,205,000	–	190,000	–	1.79%	–
LSACU	New	LIFESCI ACQUISITION CORPunit 03/31/2025	$6,160,000	–	560,000	–	1.78%	–
ALT	New	ALTIMMUNE INC	$5,757,000	–	537,500	–	1.66%	–
VIR	New	VIR BIOTECHNOLOGY INC	$5,203,000	–	127,000	–	1.50%	–
VSTM	New	VERASTEM INC	$4,558,000	–	2,650,000	–	1.32%	–
DRNA	New	DICERNA PHARMACEUTICALS INC	$4,318,000	–	170,000	–	1.25%	–
ARVN	New	ARVINAS INC	$4,125,000	–	123,000	–	1.19%	–
ALDX	New	ALDEYRA THERAPEUTICS INC	$3,711,000	–	890,000	–	1.07%	–
AGEN	New	AGENUS INC	$3,665,000	–	932,500	–	1.06%	–
SNDX	New	SYNDAX PHARMACEUTICALS INC	$3,568,000	–	240,744	–	1.03%	–
ISEE	New	IVERIC BIO INC	$3,506,000	–	687,500	–	1.01%	–
RNA	New	AVIDITY BIOSCIENCES INC	$3,321,000	–	117,500	–	0.96%	–
EIGR	New	EIGER BIOPHARMACEUTICALS INC	$2,808,000	–	292,500	–	0.81%	–
QURE	New	UNIQURE NV	$2,704,000	–	60,000	–	0.78%	–
ARWR	New	ARROWHEAD PHARMACEUTICALS IN	$2,591,000	–	60,000	–	0.75%	–
RETA	New	REATA PHARMACEUTICALS INCcl a	$2,387,000	–	15,300	–	0.69%	–
FUSN	New	FUSION PHARMACEUTICALS INC	$2,358,000	–	135,000	–	0.68%	–
GBIO	New	GENERATION BIO CO	$2,100,000	–	100,000	–	0.61%	–
CRDF	New	CARDIFF ONCOLOGY INC	$2,042,000	–	407,500	–	0.59%	–
SURF	New	SURFACE ONCOLOGY INC	$1,476,000	–	225,000	–	0.43%	–
WVE	New	WAVE LIFE SCIENCES LTD	$1,119,000	–	107,500	–	0.32%	–
STSA	New	SATSUMA PHARMACEUTICALS INC	$1,007,000	–	35,000	–	0.29%	–
AKUS	New	AKOUOS INC	$500,000	–	22,200	–	0.14%	–

Q4 2019

			Value		Shares		↓ Weighting
CEMI	Exit	CHEMBIO DIAGNOSTICS INC	$0	–	-41,667	–	-0.18%	–
SNSS	Exit	SUNESIS PHARMACEUTICALS INC	$0	–	-400,000	–	-0.21%	–
KALV	Exit	KALVISTA PHARMACEUTICALS INC	$0	–	-25,000	–	-0.21%	–
APLT	Exit	APPLIED THERAPEUTICS INC	$0	–	-83,000	–	-0.66%	–
FOLD	Exit	AMICUS THERAPEUTICS INC	$0	–	-140,000	–	-0.81%	–
PTCT	Exit	PTC THERAPEUTICS INC	$0	–	-36,000	–	-0.88%	–
MRUS	Exit	MERUS N V	$0	–	-69,274	–	-0.89%	–
ASMB	Exit	ASSEMBLY BIOSCIENCES INC	$0	–	-131,500	–	-0.93%	–
RARX	Exit	RA PHARMACEUTICALS INC	$0	–	-55,000	–	-0.94%	–
ZYME	Exit	ZYMEWORKS INC	$0	–	-52,500	–	-0.94%	–
MRTX	Exit	MIRATI THERAPEUTICS INC	$0	–	-17,000	–	-0.96%	–
KURA	Exit	KURA ONCOLOGY INC	$0	–	-95,000	–	-1.04%	–
AMRN	Exit	AMARIN CORP PLCspons adr new	$0	–	-100,000	–	-1.09%	–
IRIX	Exit	IRIDEX CORP	$0	–	-1,171,300	–	-1.56%	–
KPTI	Exit	KARYOPHARM THERAPEUTICS INC	$0	–	-237,500	–	-1.65%	–
ARGX	Exit	ARGENX SEsponsored adr	$0	–	-22,500	–	-1.85%	–
VCYT	Exit	VERACYTE INC	$0	–	-112,500	–	-1.95%	–
RETA	Exit	REATA PHARMACEUTICALS INCcl a	$0	–	-45,000	–	-2.61%	–
INSM	Exit	INSMED INC	$0	–	-220,000	–	-2.80%	–
AUPH	Exit	AURINIA PHARMACEUTICALS INC	$0	–	-850,000	–	-3.28%	–
BLU	Exit	BELLUS HEALTH INC NEW	$0	–	-785,000	–	-3.62%	–
PTGX	Exit	PROTAGONIST THERAPEUTICS INC	$0	–	-418,500	–	-3.63%	–
CRSP	Exit	CRISPR THERAPEUTICS AGnamen akt	$0	–	-134,000	–	-3.96%	–
XENE	Exit	XENON PHARMACEUTICALS INC	$0	–	-702,500	–	-4.57%	–
MIST	Exit	MILESTONE PHARMACEUTICALS IN	$0	–	-369,500	–	-4.97%	–
AXSM	Exit	AXSOME THERAPEUTICS INC	$0	–	-522,500	–	-7.63%	–
ARWR	Exit	ARROWHEAD PHARMACEUTICALS IN	$0	–	-387,500	–	-7.88%	–
XBI	Exit	SPDR SERIES TRUSTput	$0	–	-150,000	–	-8.26%	–
ARVN	Exit	ARVINAS INC	$0	–	-566,500	–	-8.81%	–
IOVA	Exit	IOVANCE BIOTHERAPEUTICS INC	$0	–	-727,500	–	-9.56%	–
KDMN	Exit	KADMON HLDGS INC	$0	–	-6,412,500	–	-11.66%	–

Q3 2019

			Value		Shares		↓ Weighting
KDMN	Sell	KADMON HLDGS INC	$16,160,000	+3.0%	6,412,500	-15.8%	11.66%	+109.0%
IOVA	Sell	IOVANCE BIOTHERAPEUTICS INC	$13,241,000	-77.7%	727,500	-70.0%	9.56%	-54.8%
ARVN	Buy	ARVINAS INC	$12,208,000	+0.8%	566,500	+2.8%	8.81%	+104.5%
XBI	Sell	SPDR SERIES TRUSTput	$11,438,000	-34.8%	150,000	-25.0%	8.26%	+32.4%
ARWR	Sell	ARROWHEAD PHARMACEUTICALS IN	$10,920,000	-13.9%	387,500	-19.0%	7.88%	+74.8%
AXSM	Buy	AXSOME THERAPEUTICS INC	$10,575,000	-6.1%	522,500	+19.4%	7.63%	+90.5%
MIST	Buy	MILESTONE PHARMACEUTICALS IN	$6,891,000	-26.9%	369,500	+6.5%	4.97%	+48.5%
XENE	Buy	XENON PHARMACEUTICALS INC	$6,330,000	-8.5%	702,500	+0.1%	4.57%	+85.7%
CRSP	Buy	CRISPR THERAPEUTICS AGnamen akt	$5,493,000	+47.6%	134,000	+69.6%	3.96%	+199.7%
PTGX	Sell	PROTAGONIST THERAPEUTICS INC	$5,026,000	-38.2%	418,500	-37.7%	3.63%	+25.4%
BLU	New	BELLUS HEALTH INC NEW	$5,016,000	–	785,000	–	3.62%	–
AUPH	Sell	AURINIA PHARMACEUTICALS INC	$4,539,000	-26.2%	850,000	-9.1%	3.28%	+49.7%
INSM	Sell	INSMED INC	$3,881,000	-65.2%	220,000	-49.5%	2.80%	-29.3%
RETA	New	REATA PHARMACEUTICALS INCcl a	$3,613,000	–	45,000	–	2.61%	–
VCYT	Sell	VERACYTE INC	$2,700,000	-80.3%	112,500	-76.6%	1.95%	-60.1%
ARGX	Sell	ARGENX SEsponsored adr	$2,564,000	-77.6%	22,500	-72.2%	1.85%	-54.6%
KPTI	New	KARYOPHARM THERAPEUTICS INC	$2,285,000	–	237,500	–	1.65%	–
AMRN	New	AMARIN CORP PLCspons adr new	$1,516,000	–	100,000	–	1.09%	–
KURA	New	KURA ONCOLOGY INC	$1,441,000	–	95,000	–	1.04%	–
MRTX	Sell	MIRATI THERAPEUTICS INC	$1,324,000	-79.4%	17,000	-72.8%	0.96%	-58.2%
ZYME	New	ZYMEWORKS INC	$1,302,000	–	52,500	–	0.94%	–
RARX	New	RA PHARMACEUTICALS INC	$1,301,000	–	55,000	–	0.94%	–
ASMB	Sell	ASSEMBLY BIOSCIENCES INC	$1,293,000	-39.3%	131,500	-16.8%	0.93%	+23.1%
MRUS	New	MERUS N V	$1,234,000	–	69,274	–	0.89%	–
PTCT	New	PTC THERAPEUTICS INC	$1,218,000	–	36,000	–	0.88%	–
FOLD	Sell	AMICUS THERAPEUTICS INC	$1,123,000	-74.3%	140,000	-60.0%	0.81%	-47.8%
APLT	New	APPLIED THERAPEUTICS INC	$912,000	–	83,000	–	0.66%	–
KALV	Sell	KALVISTA PHARMACEUTICALS INC	$290,000	-93.9%	25,000	-88.3%	0.21%	-87.5%
SNSS	New	SUNESIS PHARMACEUTICALS INC	$288,000	–	400,000	–	0.21%	–
CMRX	Exit	CHIMERIX INC	$0	–	-280,000	–	-0.43%	–
DHR	Exit	DANAHER CORPORATION	$0	–	-11,500	–	-0.58%	–
BHVN	Exit	BIOHAVEN PHARMACTL HLDG CO Lput	$0	–	-50,000	–	-0.78%	–
BHVN	Exit	BIOHAVEN PHARMACTL HLDG CO Lcall	$0	–	-50,000	–	-0.78%	–
IMMU	Exit	IMMUNOMEDICS INC	$0	–	-225,000	–	-1.11%	–
DRNA	Exit	DICERNA PHARMACEUTICALS INC	$0	–	-384,500	–	-2.15%	–
VRAY	Exit	VIEWRAY INC	$0	–	-842,500	–	-2.64%	–
ATNX	Exit	ATHENEX INC	$0	–	-472,500	–	-3.33%	–
BHVN	Exit	BIOHAVEN PHARMACTL HLDG CO L	$0	–	-255,000	–	-3.97%	–
ADVM	Exit	ADVERUM BIOTECHNOLOGIES INC	$0	–	-1,190,000	–	-5.03%	–

Q2 2019

			Value		Shares		↓ Weighting
IOVA	New	IOVANCE BIOTHERAPEUTICS INC	$59,503,000	–	2,426,701	–	21.16%	–
XBI	New	SPDR SERIES TRUSTput	$17,542,000	–	200,000	–	6.24%	–
KDMN	New	KADMON HLDGS INC	$15,692,000	–	7,617,500	–	5.58%	–
ADVM	New	ADVERUM BIOTECHNOLOGIES INC	$14,149,000	–	1,190,000	–	5.03%	–
VCYT	New	VERACYTE INC	$13,728,000	–	481,500	–	4.88%	–
ARWR	New	ARROWHEAD PHARMACEUTICALS IN	$12,680,000	–	478,500	–	4.51%	–
ARVN	New	ARVINAS INC	$12,116,000	–	551,000	–	4.31%	–
ARGX	New	ARGENX SEsponsored adr	$11,468,000	–	81,000	–	4.08%	–
AXSM	New	AXSOME THERAPEUTICS INC	$11,266,000	–	437,500	–	4.01%	–
BHVN	New	BIOHAVEN PHARMACTL HLDG CO L	$11,166,000	–	255,000	–	3.97%	–
INSM	New	INSMED INC	$11,149,000	–	435,500	–	3.96%	–
MIST	New	MILESTONE PHARMACEUTICALS IN	$9,421,000	–	347,000	–	3.35%	–
ATNX	New	ATHENEX INC	$9,356,000	–	472,500	–	3.33%	–
PTGX	New	PROTAGONIST THERAPEUTICS INC	$8,132,000	–	671,500	–	2.89%	–
VRAY	New	VIEWRAY INC	$7,422,000	–	842,500	–	2.64%	–
XENE	New	XENON PHARMACEUTICALS INC	$6,917,000	–	701,500	–	2.46%	–
MRTX	New	MIRATI THERAPEUTICS INC	$6,438,000	–	62,500	–	2.29%	–
AUPH	New	AURINIA PHARMACEUTICALS INC	$6,152,000	–	935,000	–	2.19%	–
DRNA	New	DICERNA PHARMACEUTICALS INC	$6,056,000	–	384,500	–	2.15%	–
IRIX	New	IRIDEX CORP	$5,329,000	–	1,171,300	–	1.90%	–
KALV	New	KALVISTA PHARMACEUTICALS INC	$4,718,000	–	213,000	–	1.68%	–
FOLD	New	AMICUS THERAPEUTICS INC	$4,368,000	–	350,000	–	1.55%	–
CRSP	New	CRISPR THERAPEUTICS AGnamen akt	$3,721,000	–	79,000	–	1.32%	–
IMMU	New	IMMUNOMEDICS INC	$3,121,000	–	225,000	–	1.11%	–
BHVN	New	BIOHAVEN PHARMACTL HLDG CO Lcall	$2,190,000	–	50,000	–	0.78%	–
BHVN	New	BIOHAVEN PHARMACTL HLDG CO Lput	$2,190,000	–	50,000	–	0.78%	–
ASMB	New	ASSEMBLY BIOSCIENCES INC	$2,131,000	–	158,000	–	0.76%	–
DHR	New	DANAHER CORPORATION	$1,644,000	–	11,500	–	0.58%	–
CMRX	New	CHIMERIX INC	$1,210,000	–	280,000	–	0.43%	–
CEMI	New	CHEMBIO DIAGNOSTICS INC	$254,000	–	41,667	–	0.09%	–

Q4 2018

			Value		Shares		↓ Weighting
ONS	Exit	ONCOBIOLOGICS INC	$0	–	-29,082	–	-0.01%	–
GTXI	Exit	GTX INC DELput	$0	–	-100,000	–	-0.06%	–
ALIM	Exit	ALIMERA SCIENCES INC	$0	–	-267,500	–	-0.09%	–
AMAG	Exit	AMAG PHARMACEUTICALS INCput	$0	–	-40,000	–	-0.28%	–
CHRS	Exit	COHERUS BIOSCIENCES INCcall	$0	–	-50,000	–	-0.29%	–
AMRN	Exit	AMARIN CORP PLCspons adr new	$0	–	-71,000	–	-0.41%	–
ECYT	Exit	ENDOCYTE INC	$0	–	-92,000	–	-0.58%	–
BHVN	Exit	BIOHAVEN PHARMACTL HLDG CO Lcall	$0	–	-53,800	–	-0.72%	–
MGTA	Exit	MAGENTA THERAPEUTICS INC	$0	–	-170,000	–	-0.73%	–
KALV	Exit	KALVISTA PHARMACEUTICALS INC	$0	–	-128,844	–	-1.02%	–
VRAY	Exit	VIEWRAY INC	$0	–	-311,500	–	-1.04%	–
ACER	Exit	ACER THERAPEUTICS INC	$0	–	-109,270	–	-1.20%	–
ARWR	Exit	ARROWHEAD PHARMACEUTICALS INcall	$0	–	-200,000	–	-1.37%	–
BHVN	Exit	BIOHAVEN PHARMACTL HLDG CO L	$0	–	-132,500	–	-1.78%	–
ASND	Exit	ASCENDIS PHARMA A Ssponsored adr	$0	–	-71,500	–	-1.81%	–
ASMB	Exit	ASSEMBLY BIOSCIENCES INCcall	$0	–	-147,500	–	-1.95%	–
CHRS	Exit	COHERUS BIOSCIENCES INC	$0	–	-353,500	–	-2.08%	–
XENE	Exit	XENON PHARMACEUTICALS INC	$0	–	-482,500	–	-2.27%	–
MDGL	Exit	MADRIGAL PHARMACEUTICALS INC	$0	–	-33,000	–	-2.52%	–
ARGX	Exit	ARGENX SEsponsored adr	$0	–	-105,000	–	-2.84%	–
REGN	Exit	REGENERON PHARMACEUTICALSput	$0	–	-20,000	–	-2.88%	–
XBI	Exit	SPDR SERIES TRUSTput	$0	–	-100,000	–	-3.42%	–
VCYT	Exit	VERACYTE INC	$0	–	-1,092,500	–	-3.72%	–
CASM	Exit	CAS MED SYS INC	$0	–	-5,263,508	–	-4.28%	–
IRIX	Exit	IRIDEX CORP	$0	–	-1,947,500	–	-4.41%	–
ARWR	Exit	ARROWHEAD PHARMACEUTICALS IN	$0	–	-775,000	–	-5.30%	–
CEMI	Exit	CHEMBIO DIAGNOSTICS INC	$0	–	-2,030,533	–	-7.60%	–
KDMN	Exit	KADMON HLDGS INC	$0	–	-7,395,000	–	-8.81%	–
IOVA	Exit	IOVANCE BIOTHERAPEUTICS INC	$0	–	-2,222,701	–	-8.92%	–
ASMB	Exit	ASSEMBLY BIOSCIENCES INC	$0	–	-930,000	–	-12.32%	–
IMMU	Exit	IMMUNOMEDICS INC	$0	–	-2,055,500	–	-15.27%	–

Q3 2018

			Value		Shares		↓ Weighting
IMMU	Sell	IMMUNOMEDICS INC	$42,816,000	-61.9%	2,055,500	-56.7%	15.27%	-23.7%
ASMB	Sell	ASSEMBLY BIOSCIENCES INC	$34,540,000	-24.2%	930,000	-20.0%	12.32%	+51.9%
IOVA	Sell	IOVANCE BIOTHERAPEUTICS INC	$25,005,000	-51.5%	2,222,701	-44.8%	8.92%	-2.7%
KDMN	Sell	KADMON HLDGS INC	$24,699,000	-31.7%	7,395,000	-18.4%	8.81%	+36.9%
ARWR	Sell	ARROWHEAD PHARMACEUTICALS IN	$14,857,000	+6.0%	775,000	-24.8%	5.30%	+112.5%
IRIX	Sell	IRIDEX CORP	$12,367,000	-11.2%	1,947,500	-2.6%	4.41%	+78.0%
VCYT	Sell	VERACYTE INC	$10,433,000	-58.0%	1,092,500	-58.9%	3.72%	-15.9%
ARGX	Sell	ARGENX SEsponsored adr	$7,963,000	-78.8%	105,000	-76.8%	2.84%	-57.5%
MDGL	Sell	MADRIGAL PHARMACEUTICALS INC	$7,066,000	-27.4%	33,000	-5.2%	2.52%	+45.4%
XENE	Buy	XENON PHARMACEUTICALS INC	$6,369,000	+53.8%	482,500	+7.2%	2.27%	+208.3%
CHRS	Buy	COHERUS BIOSCIENCES INC	$5,833,000	+20.8%	353,500	+2.5%	2.08%	+142.0%
ASND	Sell	ASCENDIS PHARMA A Ssponsored adr	$5,066,000	-75.5%	71,500	-77.0%	1.81%	-51.0%
BHVN	Sell	BIOHAVEN PHARMACTL HLDG CO L	$4,975,000	-21.3%	132,500	-17.2%	1.78%	+57.6%
VRAY	Sell	VIEWRAY INC	$2,916,000	-71.8%	311,500	-79.2%	1.04%	-43.5%
KALV	New	KALVISTA PHARMACEUTICALS INC	$2,849,000	–	128,844	–	1.02%	–
ECYT	New	ENDOCYTE INC	$1,634,000	–	92,000	–	0.58%	–
AMRN	New	AMARIN CORP PLCspons adr new	$1,155,000	–	71,000	–	0.41%	–
AMAG	Sell	AMAG PHARMACEUTICALS INCput	$800,000	-17.9%	40,000	-20.0%	0.28%	+63.8%
ALIM	Sell	ALIMERA SCIENCES INC	$262,000	-72.5%	267,500	-72.5%	0.09%	-45.3%
GTXI	New	GTX INC DELput	$157,000	–	100,000	–	0.06%	–
TRXC	Exit	TRANSENTERIX INCput	$0	–	-25,000	–	-0.02%	–
RMTI	Exit	ROCKWELL MED INCput	$0	–	-25,000	–	-0.02%	–
MNKD	Exit	MANNKIND CORPput	$0	–	-107,500	–	-0.04%	–
ZYNE	Exit	ZYNERBA PHARMACEUTICALS INCput	$0	–	-50,000	–	-0.09%	–
PTE	Exit	POLARITYTE INCput	$0	–	-25,000	–	-0.10%	–
VIVE	Exit	VIVEVE MED INC	$0	–	-267,500	–	-0.13%	–
STAA	Exit	STAAR SURGICAL COput	$0	–	-25,000	–	-0.14%	–
OSUR	Exit	ORASURE TECHNOLOGIES INCput	$0	–	-50,000	–	-0.15%	–
ESPR	Exit	ESPERION THERAPEUTICS INC NEput	$0	–	-25,000	–	-0.17%	–
FTSV	Exit	FORTY SEVEN INC	$0	–	-73,000	–	-0.21%	–
DB	Exit	DEUTSCHE BANK AGput	$0	–	-150,000	–	-0.28%	–
KZR	Exit	KEZAR LIFE SCIENCES INC	$0	–	-100,000	–	-0.31%	–
EDIT	Exit	EDITAS MEDICINE INCcall	$0	–	-50,000	–	-0.32%	–
VCEL	Exit	VERICEL CORP	$0	–	-190,055	–	-0.33%	–
ZGNX	Exit	ZOGENIX INCput	$0	–	-45,000	–	-0.35%	–
TSRO	Exit	TESARO INC	$0	–	-50,000	–	-0.40%	–
IOVA	Exit	IOVANCE BIOTHERAPEUTICS INCcall	$0	–	-190,000	–	-0.43%	–
ZFGN	Exit	ZAFGEN INC	$0	–	-250,000	–	-0.46%	–
FENC	Exit	FENNEC PHARMACEUTICALS INC	$0	–	-250,000	–	-0.46%	–
	Exit	INOTEK PHARMACEUTICALS CORPnote 5.750% 8/0	$0	–	-3,000,000	–	-0.54%	–
MEIP	Exit	MEI PHARMA INC	$0	–	-880,087	–	-0.62%	–
ZGNX	Exit	ZOGENIX INCcall	$0	–	-82,500	–	-0.65%	–
APLS	Exit	APELLIS PHARMACEUTICALS INC	$0	–	-168,000	–	-0.66%	–
AERI	Exit	AERIE PHARMACEUTICALS INCput	$0	–	-61,000	–	-0.73%	–
CUTR	Exit	CUTERA INC	$0	–	-105,000	–	-0.75%	–
ZGNX	Exit	ZOGENIX INC	$0	–	-110,500	–	-0.87%	–
OBSV	Exit	OBSEVA SA	$0	–	-424,300	–	-1.14%	–
EEM	Exit	ISHARES TRput	$0	–	-150,000	–	-1.16%	–
VKTX	Exit	VIKING THERAPEUTICS INC	$0	–	-750,000	–	-1.27%	–
SRPT	Exit	SAREPTA THERAPEUTICS INC	$0	–	-60,000	–	-1.41%	–
CBIO	Exit	CATALYST BIOSCIENCES INC	$0	–	-830,000	–	-1.72%	–
	Exit	INTEC PHARMA LTD JERUSALEM	$0	–	-2,962,568	–	-2.32%	–

Q2 2018

			Value		Shares		↓ Weighting
IMMU	New	IMMUNOMEDICS INC	$112,433,000	–	4,750,000	–	20.02%	–
IOVA	New	IOVANCE BIOTHERAPEUTICS INC	$51,520,000	–	4,025,000	–	9.17%	–
ASMB	New	ASSEMBLY BIOSCIENCES INC	$45,562,000	–	1,162,000	–	8.11%	–
ARGX	New	ARGENX SEsponsored adr	$37,555,000	–	453,233	–	6.68%	–
KDMN	New	KADMON HLDGS INC	$36,149,000	–	9,060,014	–	6.44%	–
VCYT	New	VERACYTE INC	$24,846,000	–	2,660,210	–	4.42%	–
CEMI	New	CHEMBIO DIAGNOSTICS INC	$22,539,000	–	2,030,533	–	4.01%	–
ASND	New	ASCENDIS PHARMA A Ssponsored adr	$20,695,000	–	311,111	–	3.68%	–
ARWR	New	ARROWHEAD PHARMACEUTICALS IN	$14,012,000	–	1,030,330	–	2.49%	–
IRIX	New	IRIDEX CORP	$13,920,000	–	2,000,000	–	2.48%	–
	New	INTEC PHARMA LTD JERUSALEM	$13,035,000	–	2,962,568	–	2.32%	–
VRAY	New	VIEWRAY INC	$10,345,000	–	1,495,000	–	1.84%	–
CASM	New	CAS MED SYS INC	$10,264,000	–	5,263,508	–	1.83%	–
MDGL	New	MADRIGAL PHARMACEUTICALS INC	$9,734,000	–	34,803	–	1.73%	–
CBIO	New	CATALYST BIOSCIENCES INC	$9,686,000	–	830,000	–	1.72%	–
XBI	New	SPDR SERIES TRUSTput	$9,519,000	–	100,000	–	1.70%	–
SRPT	New	SAREPTA THERAPEUTICS INC	$7,931,000	–	60,000	–	1.41%	–
VKTX	New	VIKING THERAPEUTICS INC	$7,118,000	–	750,000	–	1.27%	–
REGN	New	REGENERON PHARMACEUTICALSput	$6,900,000	–	20,000	–	1.23%	–
EEM	New	ISHARES TRput	$6,500,000	–	150,000	–	1.16%	–
OBSV	New	OBSEVA SA	$6,424,000	–	424,300	–	1.14%	–
BHVN	New	BIOHAVEN PHARMACTL HLDG CO L	$6,323,000	–	160,000	–	1.13%	–
ASMB	New	ASSEMBLY BIOSCIENCES INCcall	$5,783,000	–	147,500	–	1.03%	–
ZGNX	New	ZOGENIX INC	$4,884,000	–	110,500	–	0.87%	–
CHRS	New	COHERUS BIOSCIENCES INC	$4,830,000	–	345,000	–	0.86%	–
CUTR	New	CUTERA INC	$4,232,000	–	105,000	–	0.75%	–
XENE	New	XENON PHARMACEUTICALS INC	$4,140,000	–	450,000	–	0.74%	–
AERI	New	AERIE PHARMACEUTICALS INCput	$4,122,000	–	61,000	–	0.73%	–
APLS	New	APELLIS PHARMACEUTICALS INC	$3,696,000	–	168,000	–	0.66%	–
ZGNX	New	ZOGENIX INCcall	$3,647,000	–	82,500	–	0.65%	–
MEIP	New	MEI PHARMA INC	$3,468,000	–	880,087	–	0.62%	–
	New	INOTEK PHARMACEUTICALS CORPnote 5.750% 8/0	$3,022,000	–	3,000,000	–	0.54%	–
ARWR	New	ARROWHEAD PHARMACEUTICALS INcall	$2,720,000	–	200,000	–	0.48%	–
FENC	New	FENNEC PHARMACEUTICALS INC	$2,610,000	–	250,000	–	0.46%	–
ZFGN	New	ZAFGEN INC	$2,558,000	–	250,000	–	0.46%	–
IOVA	New	IOVANCE BIOTHERAPEUTICS INCcall	$2,432,000	–	190,000	–	0.43%	–
ACER	New	ACER THERAPEUTICS INC	$2,360,000	–	109,270	–	0.42%	–
MGTA	New	MAGENTA THERAPEUTICS INC	$2,295,000	–	170,000	–	0.41%	–
TSRO	New	TESARO INC	$2,224,000	–	50,000	–	0.40%	–
BHVN	New	BIOHAVEN PHARMACTL HLDG CO Lcall	$2,126,000	–	53,800	–	0.38%	–
ZGNX	New	ZOGENIX INCput	$1,989,000	–	45,000	–	0.35%	–
VCEL	New	VERICEL CORP	$1,844,000	–	190,055	–	0.33%	–
EDIT	New	EDITAS MEDICINE INCcall	$1,792,000	–	50,000	–	0.32%	–
KZR	New	KEZAR LIFE SCIENCES INC	$1,730,000	–	100,000	–	0.31%	–
DB	New	DEUTSCHE BANK AGput	$1,593,000	–	150,000	–	0.28%	–
FTSV	New	FORTY SEVEN INC	$1,168,000	–	73,000	–	0.21%	–
ESPR	New	ESPERION THERAPEUTICS INC NEput	$980,000	–	25,000	–	0.17%	–
AMAG	New	AMAG PHARMACEUTICALS INCput	$975,000	–	50,000	–	0.17%	–
ALIM	New	ALIMERA SCIENCES INC	$953,000	–	974,318	–	0.17%	–
OSUR	New	ORASURE TECHNOLOGIES INCput	$824,000	–	50,000	–	0.15%	–
STAA	New	STAAR SURGICAL COput	$775,000	–	25,000	–	0.14%	–
VIVE	New	VIVEVE MED INC	$728,000	–	267,500	–	0.13%	–
CHRS	New	COHERUS BIOSCIENCES INCcall	$700,000	–	50,000	–	0.12%	–
PTE	New	POLARITYTE INCput	$589,000	–	25,000	–	0.10%	–
ZYNE	New	ZYNERBA PHARMACEUTICALS INCput	$487,000	–	50,000	–	0.09%	–
MNKD	New	MANNKIND CORPput	$204,000	–	107,500	–	0.04%	–
RMTI	New	ROCKWELL MED INCput	$123,000	–	25,000	–	0.02%	–
TRXC	New	TRANSENTERIX INCput	$109,000	–	25,000	–	0.02%	–
ONS	New	ONCOBIOLOGICS INC	$25,000	–	29,082	–	0.00%	–

Q4 2017

			Value		Shares		↓ Weighting
ONSIZ	Exit	ONCOBIOLOGICS INC*w exp 05/18/201	$0	–	-96,833	–	-0.00%	–
ONSIW	Exit	ONCOBIOLOGICS INC*w exp 02/18/201	$0	–	-96,833	–	-0.00%	–
ONS	Exit	ONCOBIOLOGICS INC	$0	–	-29,082	–	-0.01%	–
OTIC	Exit	OTONOMY INCcall	$0	–	-17,500	–	-0.01%	–
AXGT	Exit	AXOVANT SCIENCES LTDcall	$0	–	-20,300	–	-0.02%	–
DBVT	Exit	DBV TECHNOLOGIES S Acall	$0	–	-9,000	–	-0.07%	–
LXRX	Exit	LEXICON PHARMACEUTICALS INCput	$0	–	-40,000	–	-0.09%	–
MNKD	Exit	MANNKIND CORPput	$0	–	-350,000	–	-0.14%	–
MDXG	Exit	MIMEDX GROUP INCput	$0	–	-70,000	–	-0.15%	–
CBMX	Exit	COMBIMATRIX CORPORATION	$0	–	-111,912	–	-0.15%	–
AMAG	Exit	AMAG PHARMACEUTICALS INCput	$0	–	-50,000	–	-0.16%	–
GKOS	Exit	GLAUKOS CORPput	$0	–	-30,000	–	-0.18%	–
TDOC	Exit	TELADOC INCput	$0	–	-30,000	–	-0.18%	–
RARX	Exit	RA PHARMACEUTICALS INC	$0	–	-71,500	–	-0.19%	–
PTLA	Exit	PORTOLA PHARMACEUTICALS INCput	$0	–	-20,000	–	-0.19%	–
EVTC	Exit	EVERTEC INCput	$0	–	-68,800	–	-0.20%	–
ALIM	Exit	ALIMERA SCIENCES INC	$0	–	-974,318	–	-0.24%	–
AXDX	Exit	ACCELERATE DIAGNOSTICS INCput	$0	–	-60,000	–	-0.24%	–
CBMXW	Exit	COMBIMATRIX CORPORATION*w exp 03/18/202	$0	–	-564,200	–	-0.25%	–
AIMT	Exit	AIMMUNE THERAPEUTICS INC	$0	–	-58,525	–	-0.26%	–
EVH	Exit	EVOLENT HEALTH INCcall	$0	–	-83,000	–	-0.26%	–
GOGO	Exit	GOGO INCput	$0	–	-135,000	–	-0.29%	–
NITE	Exit	NIGHTSTAR THERAPEUTICS PLCadr	$0	–	-100,000	–	-0.34%	–
CNC	Exit	CENTENE CORP DELput	$0	–	-20,000	–	-0.35%	–
ALXN	Exit	ALEXION PHARMACEUTICALS INC	$0	–	-15,000	–	-0.38%	–
RMTI	Exit	ROCKWELL MED INCput	$0	–	-250,000	–	-0.38%	–
SGEN	Exit	SEATTLE GENETICS INCcall	$0	–	-40,000	–	-0.39%	–
FOLD	Exit	AMICUS THERAPEUTICS INCcall	$0	–	-151,000	–	-0.41%	–
LCI	Exit	LANNET INCput	$0	–	-127,500	–	-0.42%	–
ACAD	Exit	ACADIA PHARMACEUTICALS INCcall	$0	–	-70,000	–	-0.47%	–
FENC	Exit	FENNEC PHARMACEUTICALS INC	$0	–	-250,000	–	-0.50%	–
QTNT	Exit	QUOTIENT LTD	$0	–	-569,145	–	-0.50%	–
TOCA	Exit	TOCAGEN INC	$0	–	-251,112	–	-0.56%	–
	Exit	NABRIVA THERAPEUTICS PLC	$0	–	-400,000	–	-0.59%	–
SGEN	Exit	SEATTLE GENETICS INCput	$0	–	-70,000	–	-0.68%	–
VIVE	Exit	VIVEVE MED INC	$0	–	-827,340	–	-0.78%	–
FXI	Exit	ISHARES TRput	$0	–	-100,000	–	-0.79%	–
FOLD	Exit	AMICUS THERAPEUTICS INC	$0	–	-300,000	–	-0.81%	–
CASM	Exit	CAS MED SYS INC	$0	–	-5,093,276	–	-0.84%	–
ARGX	Exit	ARGENX SEsponsored adr	$0	–	-216,255	–	-0.88%	–
NVTA	Exit	INVITAE CORP	$0	–	-528,000	–	-0.89%	–
BCRX	Exit	BIOCRYST PHARMACEUTICALS	$0	–	-996,300	–	-0.94%	–
ZGNX	Exit	ZOGENIX INCput	$0	–	-160,000	–	-1.00%	–
JNJ	Exit	JOHNSON & JOHNSONput	$0	–	-45,000	–	-1.05%	–
ACAD	Exit	ACADIA PHARMACEUTICALS INC	$0	–	-170,000	–	-1.15%	–
CLVS	Exit	CLOVIS ONCOLOGY INCcall	$0	–	-80,000	–	-1.18%	–
VRAY	Exit	VIEWRAY INC	$0	–	-1,331,983	–	-1.38%	–
EVH	Exit	EVOLENT HEALTH INCcl a	$0	–	-450,000	–	-1.44%	–
DBVT	Exit	DBV TECHNOLOGIES S Asponsored adr	$0	–	-192,000	–	-1.46%	–
DBVT	Exit	DBV TECHNOLOGIES S Aput	$0	–	-200,000	–	-1.52%	–
ZGNX	Exit	ZOGENIX INC	$0	–	-250,000	–	-1.57%	–
IMMU	Exit	IMMUNOMEDICS INCcall	$0	–	-667,500	–	-1.67%	–
CEMI	Exit	CHEMBIO DIAGNOSTICS INC	$0	–	-1,721,299	–	-1.91%	–
KDMN	Exit	KADMON HLDGS INC	$0	–	-3,333,333	–	-2.00%	–
EDGE	Exit	EDGE THERAPEUTICS INC	$0	–	-1,253,394	–	-2.41%	–
ASND	Exit	ASCENDIS PHARMA A Ssponsored adr	$0	–	-500,000	–	-3.25%	–
IRIX	Exit	IRIDEX CORP	$0	–	-2,000,000	–	-3.36%	–
	Exit	INTEC PHARMA LTD JERUSALEM	$0	–	-2,724,283	–	-4.37%	–
IOVA	Exit	IOVANCE BIOTHERAPEUTICS INC	$0	–	-3,431,809	–	-4.77%	–
VCYT	Exit	VERACYTE INC	$0	–	-3,295,111	–	-5.18%	–
ASMB	Exit	ASSEMBLY BIOSCIENCES INC	$0	–	-1,000,000	–	-6.26%	–
XBI	Exit	SPDR SERIES TRUSTput	$0	–	-560,000	–	-8.69%	–
IWM	Exit	ISHARES TRput	$0	–	-465,000	–	-12.35%	–
IMMU	Exit	IMMUNOMEDICS INC	$0	–	-6,737,706	–	-16.88%	–

Q3 2017

			Value		Shares		↓ Weighting
IMMU	Buy	IMMUNOMEDICS INC	$94,193,000	+566.7%	6,737,706	+321.1%	16.88%	+326.9%
IWM	Buy	ISHARES TRput	$68,904,000	+34.0%	465,000	+27.4%	12.35%	-14.2%
XBI	Buy	SPDR SERIES TRUSTput	$48,479,000	+64.3%	560,000	+46.5%	8.69%	+5.2%
ASMB	Sell	ASSEMBLY BIOSCIENCES INC	$34,920,000	+64.2%	1,000,000	-2.9%	6.26%	+5.1%
VCYT	Buy	VERACYTE INC	$28,898,000	+12.6%	3,295,111	+7.0%	5.18%	-27.9%
IOVA	Buy	IOVANCE BIOTHERAPEUTICS INC	$26,597,000	+6.0%	3,431,809	+0.5%	4.77%	-32.2%
	Buy	INTEC PHARMA LTD JERUSALEM	$24,382,000	+969.4%	2,724,283	+581.1%	4.37%	+584.8%
IRIX	Buy	IRIDEX CORP	$18,740,000	+9.1%	2,000,000	+15.1%	3.36%	-30.2%
ASND	Sell	ASCENDIS PHARMA A Ssponsored adr	$18,125,000	-29.4%	500,000	-45.9%	3.25%	-54.8%
EDGE	Sell	EDGE THERAPEUTICS INC	$13,449,000	-12.9%	1,253,394	-16.7%	2.41%	-44.2%
KDMN	New	KADMON HLDGS INC	$11,167,000	–	3,333,333	–	2.00%	–
CEMI	Buy	CHEMBIO DIAGNOSTICS INC	$10,672,000	+29.9%	1,721,299	+26.7%	1.91%	-16.8%
IMMU	New	IMMUNOMEDICS INCcall	$9,332,000	–	667,500	–	1.67%	–
ZGNX	Sell	ZOGENIX INC	$8,763,000	+100.3%	250,000	-17.1%	1.57%	+28.3%
DBVT	New	DBV TECHNOLOGIES S Aput	$8,488,000	–	200,000	–	1.52%	–
DBVT	Buy	DBV TECHNOLOGIES S Asponsored adr	$8,148,000	+111.7%	192,000	+78.2%	1.46%	+35.6%
EVH	Buy	EVOLENT HEALTH INCcl a	$8,010,000	+12.6%	450,000	+60.4%	1.44%	-27.9%
VRAY	Buy	VIEWRAY INC	$7,672,000	+72.8%	1,331,983	+94.1%	1.38%	+10.6%
CLVS	New	CLOVIS ONCOLOGY INCcall	$6,592,000	–	80,000	–	1.18%	–
ACAD	Sell	ACADIA PHARMACEUTICALS INC	$6,404,000	-8.2%	170,000	-32.0%	1.15%	-41.2%
JNJ	Buy	JOHNSON & JOHNSONput	$5,850,000	+10.5%	45,000	+12.5%	1.05%	-29.2%
ZGNX	Buy	ZOGENIX INCput	$5,608,000	+286.8%	160,000	+60.0%	1.00%	+147.5%
BCRX	Buy	BIOCRYST PHARMACEUTICALS	$5,221,000	+456.6%	996,300	+490.6%	0.94%	+255.9%
NVTA	Buy	INVITAE CORP	$4,947,000	+415.8%	528,000	+426.5%	0.89%	+231.0%
ARGX	Buy	ARGENX SEsponsored adr	$4,890,000	+50.8%	216,255	+41.5%	0.88%	-3.4%
CASM	Buy	CAS MED SYS INC	$4,686,000	-15.1%	5,093,276	+7.0%	0.84%	-45.6%
FOLD	New	AMICUS THERAPEUTICS INC	$4,524,000	–	300,000	–	0.81%	–
FXI	New	ISHARES TRput	$4,404,000	–	100,000	–	0.79%	–
VIVE	Buy	VIVEVE MED INC	$4,335,000	-15.0%	827,340	+16.5%	0.78%	-45.6%
SGEN	New	SEATTLE GENETICS INCput	$3,809,000	–	70,000	–	0.68%	–
	Sell	NABRIVA THERAPEUTICS PLC	$3,276,000	-66.9%	400,000	-57.7%	0.59%	-78.8%
TOCA	New	TOCAGEN INC	$3,129,000	–	251,112	–	0.56%	–
QTNT	Buy	QUOTIENT LTD	$2,806,000	-30.8%	569,145	+3.3%	0.50%	-55.7%
FENC	New	FENNEC PHARMACEUTICALS INC	$2,773,000	–	250,000	–	0.50%	–
ACAD	New	ACADIA PHARMACEUTICALS INCcall	$2,637,000	–	70,000	–	0.47%	–
LCI	Buy	LANNET INCput	$2,352,000	+28.7%	127,500	+42.3%	0.42%	-17.8%
FOLD	New	AMICUS THERAPEUTICS INCcall	$2,277,000	–	151,000	–	0.41%	–
SGEN	New	SEATTLE GENETICS INCcall	$2,176,000	–	40,000	–	0.39%	–
RMTI	New	ROCKWELL MED INCput	$2,140,000	–	250,000	–	0.38%	–
ALXN	New	ALEXION PHARMACEUTICALS INC	$2,104,000	–	15,000	–	0.38%	–
CNC	New	CENTENE CORP DELput	$1,935,000	–	20,000	–	0.35%	–
NITE	New	NIGHTSTAR THERAPEUTICS PLCadr	$1,920,000	–	100,000	–	0.34%	–
GOGO	Buy	GOGO INCput	$1,594,000	+176.3%	135,000	+170.0%	0.29%	+77.6%
EVH	New	EVOLENT HEALTH INCcall	$1,477,000	–	83,000	–	0.26%	–
AIMT	New	AIMMUNE THERAPEUTICS INC	$1,451,000	–	58,525	–	0.26%	–
CBMXW	New	COMBIMATRIX CORPORATION*w exp 03/18/202	$1,411,000	–	564,200	–	0.25%	–
AXDX	New	ACCELERATE DIAGNOSTICS INCput	$1,347,000	–	60,000	–	0.24%	–
EVTC	New	EVERTEC INCput	$1,090,000	–	68,800	–	0.20%	–
PTLA	New	PORTOLA PHARMACEUTICALS INCput	$1,081,000	–	20,000	–	0.19%	–
RARX	Sell	RA PHARMACEUTICALS INC	$1,044,000	-85.1%	71,500	-80.9%	0.19%	-90.5%
TDOC	New	TELADOC INCput	$995,000	–	30,000	–	0.18%	–
GKOS	Buy	GLAUKOS CORPput	$990,000	-0.9%	30,000	+24.5%	0.18%	-36.8%
AMAG	New	AMAG PHARMACEUTICALS INCput	$923,000	–	50,000	–	0.16%	–
CBMX	New	COMBIMATRIX CORPORATION	$839,000	–	111,912	–	0.15%	–
MDXG	New	MIMEDX GROUP INCput	$832,000	–	70,000	–	0.15%	–
MNKD	Buy	MANNKIND CORPput	$760,000	+1552.2%	350,000	+983.6%	0.14%	+946.2%
LXRX	New	LEXICON PHARMACEUTICALS INCput	$492,000	–	40,000	–	0.09%	–
DBVT	New	DBV TECHNOLOGIES S Acall	$382,000	–	9,000	–	0.07%	–
AXGT	New	AXOVANT SCIENCES LTDcall	$140,000	–	20,300	–	0.02%	–
OTIC	New	OTONOMY INCcall	$57,000	–	17,500	–	0.01%	–
	Exit	ESSA PHARMA INC	$0	–	-442,000	–	-0.07%	–
SGMO	Exit	SANGAMO THERAPEUTICS INCput	$0	–	-30,000	–	-0.07%	–
	Exit	NEURODERM LTDput	$0	–	-10,000	–	-0.08%	–
IMGN	Exit	IMMUNOGEN INCcall	$0	–	-50,000	–	-0.10%	–
CYTK	Exit	CYTOKINETICS INCput	$0	–	-40,000	–	-0.14%	–
MYGN	Exit	MYRIAD GENETICS INCput	$0	–	-19,400	–	-0.14%	–
ACOR	Exit	ACORDA THERAPEUTICS INCput	$0	–	-30,000	–	-0.16%	–
OMER	Exit	OMEROS CORPput	$0	–	-40,000	–	-0.22%	–
VSAR	Exit	VERSARTIS INCput	$0	–	-49,100	–	-0.24%	–
INSM	Exit	INSMED INCput	$0	–	-50,000	–	-0.24%	–
ZIOP	Exit	ZIOPHARM ONCOLOGY INCput	$0	–	-150,000	–	-0.26%	–
VCYT	Exit	VERACYTE INCcall	$0	–	-160,000	–	-0.37%	–
REPH	Exit	RECRO PHARMA INC	$0	–	-200,500	–	-0.40%	–
SPNC	Exit	SPECTRANETICS CORPput	$0	–	-40,000	–	-0.43%	–
EXEL	Exit	EXELIXIS INCput	$0	–	-70,000	–	-0.48%	–
CLVS	Exit	CLOVIS ONCOLOGY INC	$0	–	-20,000	–	-0.52%	–
WBMD	Exit	WEBMD HEALTH CORP	$0	–	-33,000	–	-0.54%	–
AERI	Exit	AERIE PHARMACEUTICALS INCput	$0	–	-40,000	–	-0.59%	–
	Exit	NEURODERM LTD	$0	–	-72,866	–	-0.61%	–
IOVA	Exit	IOVANCE BIOTHERAPEUTICS INCcall	$0	–	-324,000	–	-0.67%	–
JUNO	Exit	JUNO THERAPEUTICS INCput	$0	–	-80,000	–	-0.67%	–
ACRS	Exit	ACLARIS THERAPEUTICS INC	$0	–	-90,000	–	-0.68%	–
TSRO	Exit	TESARO INC	$0	–	-23,700	–	-0.93%	–
ASMB	Exit	ASSEMBLY BIOSCIENCES INCcall	$0	–	-185,000	–	-1.07%	–
ANAB	Exit	ANAPTYSBIO INC	$0	–	-165,690	–	-1.11%	–
KITE	Exit	KITE PHARMA INC	$0	–	-75,000	–	-2.18%	–

Q2 2017

			Value		Shares		↓ Weighting
IWM	New	ISHARES TRput	$51,436,000	–	365,000	–	14.40%	–
XBI	New	SPDR SERIES TRUSTput	$29,506,000	–	382,300	–	8.26%	–
ASND	New	ASCENDIS PHARMA A Ssponsored adr	$25,664,000	–	924,483	–	7.18%	–
VCYT	New	VERACYTE INC	$25,658,000	–	3,080,145	–	7.18%	–
IOVA	New	IOVANCE BIOTHERAPEUTICS INC	$25,101,000	–	3,415,044	–	7.02%	–
ASMB	New	ASSEMBLY BIOSCIENCES INC	$21,271,000	–	1,030,072	–	5.95%	–
IRIX	New	IRIDEX CORP	$17,184,000	–	1,737,540	–	4.81%	–
EDGE	New	EDGE THERAPEUTICS INC	$15,437,000	–	1,504,612	–	4.32%	–
IMMU	New	IMMUNOMEDICS INC	$14,128,000	–	1,600,000	–	3.95%	–
	New	NABRIVA THERAPEUTICS PLC	$9,911,000	–	945,737	–	2.77%	–
CEMI	New	CHEMBIO DIAGNOSTICS INC	$8,218,000	–	1,358,351	–	2.30%	–
KITE	New	KITE PHARMA INC	$7,775,000	–	75,000	–	2.18%	–
EVH	New	EVOLENT HEALTH INCcl a	$7,113,000	–	280,600	–	1.99%	–
RARX	New	RA PHARMACEUTICALS INC	$7,000,000	–	373,507	–	1.96%	–
ACAD	New	ACADIA PHARMACEUTICALS INC	$6,973,000	–	250,000	–	1.95%	–
CASM	New	CAS MED SYS INC	$5,522,000	–	4,760,151	–	1.54%	–
JNJ	New	JOHNSON & JOHNSONput	$5,292,000	–	40,000	–	1.48%	–
VIVE	New	VIVEVE MED INC	$5,098,000	–	710,000	–	1.43%	–
VRAY	New	VIEWRAY INC	$4,441,000	–	686,387	–	1.24%	–
ZGNX	New	ZOGENIX INC	$4,375,000	–	301,700	–	1.22%	–
QTNT	New	QUOTIENT LTD	$4,057,000	–	551,196	–	1.14%	–
ANAB	New	ANAPTYSBIO INC	$3,965,000	–	165,690	–	1.11%	–
DBVT	New	DBV TECHNOLOGIES S Asponsored adr	$3,848,000	–	107,765	–	1.08%	–
ASMB	New	ASSEMBLY BIOSCIENCES INCcall	$3,820,000	–	185,000	–	1.07%	–
TSRO	New	TESARO INC	$3,315,000	–	23,700	–	0.93%	–
ARGX	New	ARGENX SEsponsored adr	$3,242,000	–	152,837	–	0.91%	–
ACRS	New	ACLARIS THERAPEUTICS INC	$2,441,000	–	90,000	–	0.68%	–
JUNO	New	JUNO THERAPEUTICS INCput	$2,391,000	–	80,000	–	0.67%	–
IOVA	New	IOVANCE BIOTHERAPEUTICS INCcall	$2,381,000	–	324,000	–	0.67%	–
	New	INTEC PHARMA LTD JERUSALEM	$2,280,000	–	400,000	–	0.64%	–
	New	NEURODERM LTD	$2,179,000	–	72,866	–	0.61%	–
AERI	New	AERIE PHARMACEUTICALS INCput	$2,102,000	–	40,000	–	0.59%	–
WBMD	New	WEBMD HEALTH CORP	$1,935,000	–	33,000	–	0.54%	–
CLVS	New	CLOVIS ONCOLOGY INC	$1,873,000	–	20,000	–	0.52%	–
LCI	New	LANNET INCput	$1,828,000	–	89,600	–	0.51%	–
EXEL	New	EXELIXIS INCput	$1,724,000	–	70,000	–	0.48%	–
SPNC	New	SPECTRANETICS CORPput	$1,536,000	–	40,000	–	0.43%	–
ZGNX	New	ZOGENIX INCput	$1,450,000	–	100,000	–	0.41%	–
REPH	New	RECRO PHARMA INC	$1,410,000	–	200,500	–	0.40%	–
ALIM	New	ALIMERA SCIENCES INC	$1,354,000	–	974,318	–	0.38%	–
VCYT	New	VERACYTE INCcall	$1,333,000	–	160,000	–	0.37%	–
GKOS	New	GLAUKOS CORPput	$999,000	–	24,100	–	0.28%	–
NVTA	New	INVITAE CORP	$959,000	–	100,292	–	0.27%	–
BCRX	New	BIOCRYST PHARMACEUTICALS	$938,000	–	168,685	–	0.26%	–
ZIOP	New	ZIOPHARM ONCOLOGY INCput	$933,000	–	150,000	–	0.26%	–
VSAR	New	VERSARTIS INCput	$857,000	–	49,100	–	0.24%	–
INSM	New	INSMED INCput	$858,000	–	50,000	–	0.24%	–
OMER	New	OMEROS CORPput	$796,000	–	40,000	–	0.22%	–
ACOR	New	ACORDA THERAPEUTICS INCput	$591,000	–	30,000	–	0.16%	–
GOGO	New	GOGO INCput	$577,000	–	50,000	–	0.16%	–
MYGN	New	MYRIAD GENETICS INCput	$501,000	–	19,400	–	0.14%	–
CYTK	New	CYTOKINETICS INCput	$484,000	–	40,000	–	0.14%	–
IMGN	New	IMMUNOGEN INCcall	$356,000	–	50,000	–	0.10%	–
	New	NEURODERM LTDput	$299,000	–	10,000	–	0.08%	–
SGMO	New	SANGAMO THERAPEUTICS INCput	$264,000	–	30,000	–	0.07%	–
	New	ESSA PHARMA INC	$242,000	–	442,000	–	0.07%	–
MNKD	New	MANNKIND CORPput	$46,000	–	32,300	–	0.01%	–
ONS	New	ONCOBIOLOGICS INC	$29,000	–	29,082	–	0.01%	–
ONSIW	New	ONCOBIOLOGICS INC*w exp 02/18/201	$17,000	–	96,833	–	0.01%	–
ONSIZ	New	ONCOBIOLOGICS INC*w exp 05/18/201	$9,000	–	96,833	–	0.00%	–

Q4 2016

			Value		Shares		↓ Weighting
PTX	Exit	PERNIX THERAPEUTICS HLDGS INput	$0	–	-73,500	–	-0.02%	–
RIGL	Exit	RIGEL PHARMACEUTICALS INCput	$0	–	-11,900	–	-0.02%	–
ONSIW	Exit	ONCOBIOLOGICS INC*w exp 02/18/201	$0	–	-96,833	–	-0.02%	–
MNKD	Exit	MANNKIND CORPput	$0	–	-90,000	–	-0.02%	–
ONSIZ	Exit	ONCOBIOLOGICS INC*w exp 05/18/201	$0	–	-96,833	–	-0.04%	–
AGTC	Exit	APPLIED GENETIC TECHNOL CORP	$0	–	-10,193	–	-0.04%	–
CBMX	Exit	COMBIMATRIX CORPORATION	$0	–	-47,431	–	-0.05%	–
IMMU	Exit	IMMUNOMEDICS INCcall	$0	–	-58,600	–	-0.07%	–
AKTX	Exit	AKARI THERAPEUTICS PLCsponsored adr	$0	–	-23,169	–	-0.07%	–
BCRX	Exit	BIOCRYST PHARMACEUTICALSput	$0	–	-50,600	–	-0.08%	–
DXTRQ	Exit	DEXTERA SURGICAL INC	$0	–	-128,958	–	-0.09%	–
PGNX	Exit	PROGENICS PHARMACEUTICALS INcall	$0	–	-40,000	–	-0.10%	–
ARDX	Exit	ARDELYX INC	$0	–	-26,076	–	-0.13%	–
TROV	Exit	TROVAGENE INCput	$0	–	-80,000	–	-0.14%	–
RIGL	Exit	RIGEL PHARMACEUTICALS INCcall	$0	–	-100,000	–	-0.14%	–
BCRX	Exit	BIOCRYST PHARMACEUTICALScall	$0	–	-107,200	–	-0.18%	–
CRBP	Exit	CORBUS PHARMACEUTICALS HLDGS	$0	–	-81,302	–	-0.21%	–
EHIC	Exit	EHI CAR SVCS LTDspon ads cl a	$0	–	-58,827	–	-0.23%	–
THC	Exit	TENET HEALTHCARE CORP	$0	–	-32,809	–	-0.28%	–
AGEN	Exit	AGENUS INC	$0	–	-104,178	–	-0.28%	–
MRTX	Exit	MIRATI THERAPEUTICS INC	$0	–	-125,000	–	-0.31%	–
AZN	Exit	ASTRAZENECA PLCsponsored adr	$0	–	-30,000	–	-0.37%	–
ONS	Exit	ONCOBIOLOGICS INC	$0	–	-245,391	–	-0.39%	–
ATRC	Exit	ATRICURE INC	$0	–	-66,186	–	-0.39%	–
SVA	Exit	SINOVAC BIOTECH LTD	$0	–	-204,358	–	-0.45%	–
ACAD	Exit	ACADIA PHARMACEUTICALS INCcall	$0	–	-40,000	–	-0.48%	–
AGIO	Exit	AGIOS PHARMACEUTICALS INC	$0	–	-25,000	–	-0.50%	–
ALIM	Exit	ALIMERA SCIENCES INC	$0	–	-974,318	–	-0.54%	–
	Exit	ESSA PHARMA INC	$0	–	-586,700	–	-0.63%	–
ALR	Exit	ALERE INC	$0	–	-45,000	–	-0.73%	–
DBVT	Exit	DBV TECHNOLOGIES S Asponsored adr	$0	–	-56,260	–	-0.77%	–
GHDX	Exit	GENOMIC HEALTH INC	$0	–	-72,100	–	-0.78%	–
RDUS	Exit	RADIUS HEALTH INC	$0	–	-40,000	–	-0.81%	–
AERI	Exit	AERIE PHARMACEUTICALS INCcall	$0	–	-59,600	–	-0.84%	–
ASMB	Exit	ASSEMBLY BIOSCIENCES INC	$0	–	-314,211	–	-0.85%	–
TSRO	Exit	TESARO INC	$0	–	-22,700	–	-0.85%	–
SRPT	Exit	SAREPTA THERAPEUTICS INCcall	$0	–	-39,700	–	-0.92%	–
BCRX	Exit	BIOCRYST PHARMACEUTICALS	$0	–	-554,448	–	-0.92%	–
PGNX	Exit	PROGENICS PHARMACEUTICALS IN	$0	–	-432,370	–	-1.03%	–
BMRN	Exit	BIOMARIN PHARMACEUTICAL INC	$0	–	-30,000	–	-1.04%	–
SRPT	Exit	SAREPTA THERAPEUTICS INC	$0	–	-50,000	–	-1.15%	–
DERM	Exit	DERMIRA INC	$0	–	-107,000	–	-1.36%	–
INNL	Exit	INNOCOLL HLDGS PLC	$0	–	-671,517	–	-1.46%	–
VNDA	Exit	VANDA PHARMACEUTICALS INC	$0	–	-245,995	–	-1.54%	–
NBRV	Exit	NABRIVA THERAPEUTICS AGsponsored adr	$0	–	-583,521	–	-1.54%	–
WBMD	Exit	WEBMD HEALTH CORP	$0	–	-95,000	–	-1.77%	–
FOLD	Exit	AMICUS THERAPEUTICS INC	$0	–	-670,000	–	-1.86%	–
IWM	Exit	ISHARES TRput	$0	–	-40,000	–	-1.86%	–
CEMP	Exit	CEMPRA INC	$0	–	-210,000	–	-1.91%	–
OXFD	Exit	OXFORD IMMUNOTEC GLOBAL PLC	$0	–	-407,815	–	-1.92%	–
GWPH	Exit	GW PHARMACEUTICALS PLCads	$0	–	-41,487	–	-2.07%	–
CEMI	Exit	CHEMBIO DIAGNOSTICS INC	$0	–	-771,676	–	-2.14%	–
	Exit	IMMUNOMEDICS INCnote 4.750% 2/1	$0	–	-7,500,000	–	-2.38%	–
AKBA	Exit	AKEBIA THERAPEUTICS INC	$0	–	-700,000	–	-2.38%	–
CASM	Exit	CAS MED SYS INC	$0	–	-3,845,365	–	-2.50%	–
MRVL	Exit	MARVELL TECHNOLOGY GROUP LTDord	$0	–	-510,000	–	-2.54%	–
ACAD	Exit	ACADIA PHARMACEUTICALS INC	$0	–	-220,000	–	-2.63%	–
ASND	Exit	ASCENDIS PHARMA A Ssponsored adr	$0	–	-363,000	–	-2.74%	–
EDGE	Exit	EDGE THERAPEUTICS INC	$0	–	-703,000	–	-2.75%	–
	Exit	NEURODERM LTD	$0	–	-462,956	–	-3.21%	–
XBI	Exit	SPDR SERIES TRUSTput	$0	–	-150,000	–	-3.73%	–
AERI	Exit	AERIE PHARMACEUTICALS INC	$0	–	-280,000	–	-3.97%	–
EVDY	Exit	EVERYDAY HEALTH INC	$0	–	-1,550,000	–	-4.48%	–
IMMU	Exit	IMMUNOMEDICS INC	$0	–	-3,850,000	–	-4.70%	–
IRIX	Exit	IRIDEX CORP	$0	–	-1,220,611	–	-6.64%	–
VCYT	Exit	VERACYTE INC	$0	–	-3,144,649	–	-8.98%	–
LBIO	Exit	LION BIOTECHNOLOGIES INC	$0	–	-3,229,916	–	-9.98%	–

Q3 2016

			Value		Shares		↓ Weighting
LBIO	Sell	LION BIOTECHNOLOGIES INC	$26,582,000	+1.5%	3,229,916	-0.1%	9.98%	-20.7%
VCYT	Sell	VERACYTE INC	$23,931,000	+49.3%	3,144,649	-1.3%	8.98%	+16.6%
IRIX	Buy	IRIDEX CORP	$17,687,000	+18.2%	1,220,611	+20.6%	6.64%	-7.7%
IMMU	Sell	IMMUNOMEDICS INC	$12,513,000	+28.4%	3,850,000	-8.3%	4.70%	+0.3%
EVDY	Buy	EVERYDAY HEALTH INC	$11,920,000	+60.1%	1,550,000	+64.0%	4.48%	+25.1%
AERI	New	AERIE PHARMACEUTICALS INC	$10,567,000	–	280,000	–	3.97%	–
XBI	New	SPDR SERIES TRUSTput	$9,944,000	–	150,000	–	3.73%	–
	Sell	NEURODERM LTD	$8,560,000	-16.9%	462,956	-27.0%	3.21%	-35.1%
EDGE	Buy	EDGE THERAPEUTICS INC	$7,318,000	+36.6%	703,000	+32.6%	2.75%	+6.7%
ASND	Sell	ASCENDIS PHARMA A Ssponsored adr	$7,296,000	+16.3%	363,000	-23.2%	2.74%	-9.2%
ACAD	Buy	ACADIA PHARMACEUTICALS INC	$6,998,000	+150.6%	220,000	+155.8%	2.63%	+95.8%
MRVL	Buy	MARVELL TECHNOLOGY GROUP LTDord	$6,768,000	+196.5%	510,000	+112.9%	2.54%	+131.6%
CASM	Buy	CAS MED SYS INC	$6,647,000	+3.2%	3,845,365	+9.8%	2.50%	-19.4%
AKBA	Buy	AKEBIA THERAPEUTICS INC	$6,335,000	+41.2%	700,000	+16.7%	2.38%	+10.3%
	Buy	IMMUNOMEDICS INCnote 4.750% 2/1	$6,333,000	+69.6%	7,500,000	+36.4%	2.38%	+32.6%
CEMI	Buy	CHEMBIO DIAGNOSTICS INC	$5,710,000	+5610.0%	771,676	+6235.6%	2.14%	+4366.7%
GWPH	New	GW PHARMACEUTICALS PLCads	$5,507,000	–	41,487	–	2.07%	–
OXFD	Sell	OXFORD IMMUNOTEC GLOBAL PLC	$5,122,000	+36.4%	407,815	-2.3%	1.92%	+6.5%
IWM	Sell	ISHARES TRput	$4,968,000	-13.6%	40,000	-20.0%	1.86%	-32.5%
FOLD	Sell	AMICUS THERAPEUTICS INC	$4,958,000	-21.8%	670,000	-42.3%	1.86%	-38.9%
WBMD	Buy	WEBMD HEALTH CORP	$4,722,000	+225.0%	95,000	+280.0%	1.77%	+154.0%
NBRV	Buy	NABRIVA THERAPEUTICS AGsponsored adr	$4,114,000	-1.8%	583,521	+4.4%	1.54%	-23.3%
VNDA	New	VANDA PHARMACEUTICALS INC	$4,093,000	–	245,995	–	1.54%	–
INNL	Buy	INNOCOLL HLDGS PLC	$3,902,000	+24.7%	671,517	+18.2%	1.46%	-2.6%
DERM	Sell	DERMIRA INC	$3,619,000	-27.2%	107,000	-37.1%	1.36%	-43.1%
SRPT	Sell	SAREPTA THERAPEUTICS INC	$3,071,000	+23.9%	50,000	-61.5%	1.15%	-3.2%
BMRN	Sell	BIOMARIN PHARMACEUTICAL INC	$2,776,000	-44.2%	30,000	-53.1%	1.04%	-56.5%
PGNX	Sell	PROGENICS PHARMACEUTICALS IN	$2,737,000	+44.5%	432,370	-3.7%	1.03%	+13.0%
BCRX	New	BIOCRYST PHARMACEUTICALS	$2,445,000	–	554,448	–	0.92%	–
SRPT	Sell	SAREPTA THERAPEUTICS INCcall	$2,438,000	+59.8%	39,700	-50.4%	0.92%	+24.8%
TSRO	Sell	TESARO INC	$2,275,000	-9.8%	22,700	-24.3%	0.85%	-29.5%
ASMB	Buy	ASSEMBLY BIOSCIENCES INC	$2,265,000	+81.1%	314,211	+39.4%	0.85%	+41.4%
AERI	New	AERIE PHARMACEUTICALS INCcall	$2,249,000	–	59,600	–	0.84%	–
RDUS	New	RADIUS HEALTH INC	$2,164,000	–	40,000	–	0.81%	–
GHDX	Buy	GENOMIC HEALTH INC	$2,085,000	+65.0%	72,100	+47.7%	0.78%	+29.0%
DBVT	New	DBV TECHNOLOGIES S Asponsored adr	$2,044,000	–	56,260	–	0.77%	–
ALR	New	ALERE INC	$1,946,000	–	45,000	–	0.73%	–
	Buy	ESSA PHARMA INC	$1,678,000	-4.3%	586,700	+2.9%	0.63%	-25.3%
AGIO	New	AGIOS PHARMACEUTICALS INC	$1,321,000	–	25,000	–	0.50%	–
ACAD	New	ACADIA PHARMACEUTICALS INCcall	$1,272,000	–	40,000	–	0.48%	–
SVA	Buy	SINOVAC BIOTECH LTD	$1,206,000	+53.4%	204,358	+54.2%	0.45%	+19.8%
ATRC	Sell	ATRICURE INC	$1,047,000	-34.4%	66,186	-41.4%	0.39%	-48.8%
ONS	Buy	ONCOBIOLOGICS INC	$1,043,000	+26.0%	245,391	+0.8%	0.39%	-1.5%
AZN	New	ASTRAZENECA PLCsponsored adr	$986,000	–	30,000	–	0.37%	–
AGEN	New	AGENUS INC	$748,000	–	104,178	–	0.28%	–
THC	New	TENET HEALTHCARE CORP	$743,000	–	32,809	–	0.28%	–
EHIC	New	EHI CAR SVCS LTDspon ads cl a	$603,000	–	58,827	–	0.23%	–
CRBP	New	CORBUS PHARMACEUTICALS HLDGS	$552,000	–	81,302	–	0.21%	–
BCRX	New	BIOCRYST PHARMACEUTICALScall	$473,000	–	107,200	–	0.18%	–
RIGL	New	RIGEL PHARMACEUTICALS INCcall	$367,000	–	100,000	–	0.14%	–
TROV	Buy	TROVAGENE INCput	$359,000	+52.1%	80,000	+53.8%	0.14%	+19.5%
ARDX	New	ARDELYX INC	$337,000	–	26,076	–	0.13%	–
PGNX	New	PROGENICS PHARMACEUTICALS INcall	$253,000	–	40,000	–	0.10%	–
BCRX	New	BIOCRYST PHARMACEUTICALSput	$223,000	–	50,600	–	0.08%	–
AKTX	Sell	AKARI THERAPEUTICS PLCsponsored adr	$197,000	-55.8%	23,169	-30.0%	0.07%	-65.4%
AGTC	New	APPLIED GENETIC TECHNOL CORP	$100,000	–	10,193	–	0.04%	–
RIGL	New	RIGEL PHARMACEUTICALS INCput	$44,000	–	11,900	–	0.02%	–
PTX	Buy	PERNIX THERAPEUTICS HLDGS INput	$46,000	+64.3%	73,500	+17.0%	0.02%	+30.8%
RLYP	Exit	RELYPSA INCcall	$0	–	-10,000	–	-0.09%	–
AUDC	Exit	AUDIOCODES LTDord	$0	–	-45,035	–	-0.09%	–
CYTR	Exit	CYTRX CORPput	$0	–	-100,000	–	-0.11%	–
CDNA	Exit	CAREDX INC	$0	–	-64,627	–	-0.13%	–
BEAT	Exit	BIOTELEMETRY INC	$0	–	-34,630	–	-0.27%	–
IRWD	Exit	IRONWOOD PHARMACEUTICALS INC	$0	–	-50,000	–	-0.31%	–
RPTP	Exit	RAPTOR PHARMACEUTICAL CORP	$0	–	-174,708	–	-0.45%	–
OLED	Exit	UNIVERSAL DISPLAY CORP	$0	–	-15,000	–	-0.49%	–
RXDX	Exit	IGNYTA INC	$0	–	-229,748	–	-0.60%	–
SGY	Exit	STONE ENERGY CORPput	$0	–	-108,100	–	-0.63%	–
CYTK	Exit	CYTOKINETICS INC	$0	–	-140,969	–	-0.64%	–
RIGL	Exit	RIGEL PHARMACEUTICALS INC	$0	–	-747,748	–	-0.80%	–
RTRX	Exit	RETROPHIN INC	$0	–	-98,788	–	-0.84%	–
NBIX	Exit	NEUROCRINE BIOSCIENCES INC	$0	–	-42,000	–	-0.92%	–
CYNA	Exit	CYNAPSUS THERAPEUTICS INC	$0	–	-115,400	–	-0.93%	–
AGN	Exit	ALLERGAN PLC	$0	–	-8,500	–	-0.94%	–
PACB	Exit	PACIFIC BIOSCIENCES CALIF IN	$0	–	-300,000	–	-1.01%	–
INSM	Exit	INSMED INC	$0	–	-220,000	–	-1.04%	–
PODD	Exit	INSULET CORP	$0	–	-75,000	–	-1.09%	–
MDVN	Exit	MEDIVATION INC	$0	–	-50,000	–	-1.45%	–
RRM	Exit	RR MEDIA LTD	$0	–	-611,818	–	-3.84%	–

Q2 2016

			Value		Shares		↓ Weighting
LBIO	New	LION BIOTECHNOLOGIES INC	$26,183,000	–	3,232,416	–	12.58%	–
VCYT	New	VERACYTE INC	$16,034,000	–	3,187,607	–	7.70%	–
IRIX	New	IRIDEX CORP	$14,966,000	–	1,011,871	–	7.19%	–
	New	NEURODERM LTD	$10,303,000	–	634,000	–	4.95%	–
IMMU	New	IMMUNOMEDICS INC	$9,744,000	–	4,200,000	–	4.68%	–
RRM	New	RR MEDIA LTD	$7,996,000	–	611,818	–	3.84%	–
EVDY	New	EVERYDAY HEALTH INC	$7,447,000	–	945,000	–	3.58%	–
CASM	New	CAS MED SYS INC	$6,441,000	–	3,500,602	–	3.10%	–
FOLD	New	AMICUS THERAPEUTICS INC	$6,342,000	–	1,161,545	–	3.05%	–
ASND	New	ASCENDIS PHARMA A Ssponsored adr	$6,274,000	–	472,800	–	3.02%	–
IWM	New	ISHARES TRput	$5,749,000	–	50,000	–	2.76%	–
EDGE	New	EDGE THERAPEUTICS INC	$5,358,000	–	530,000	–	2.58%	–
BMRN	New	BIOMARIN PHARMACEUTICAL INC	$4,979,000	–	64,000	–	2.39%	–
DERM	New	DERMIRA INC	$4,973,000	–	170,000	–	2.39%	–
AKBA	New	AKEBIA THERAPEUTICS INC	$4,488,000	–	600,000	–	2.16%	–
NBRV	New	NABRIVA THERAPEUTICS AGsponsored adr	$4,191,000	–	558,771	–	2.01%	–
OXFD	New	OXFORD IMMUNOTEC GLOBAL PLC	$3,756,000	–	417,278	–	1.80%	–
	New	IMMUNOMEDICS INCnote 4.750% 2/1	$3,733,000	–	5,500,000	–	1.79%	–
CEMP	New	CEMPRA INC	$3,463,000	–	210,000	–	1.66%	–
INNL	New	INNOCOLL HLDGS PLC	$3,130,000	–	568,137	–	1.50%	–
MDVN	New	MEDIVATION INC	$3,015,000	–	50,000	–	1.45%	–
ACAD	New	ACADIA PHARMACEUTICALS INC	$2,792,000	–	85,999	–	1.34%	–
TSRO	New	TESARO INC	$2,522,000	–	30,000	–	1.21%	–
SRPT	New	SAREPTA THERAPEUTICS INC	$2,479,000	–	130,000	–	1.19%	–
MRVL	New	MARVELL TECHNOLOGY GROUP LTDord	$2,283,000	–	239,588	–	1.10%	–
PODD	New	INSULET CORP	$2,268,000	–	75,000	–	1.09%	–
INSM	New	INSMED INC	$2,169,000	–	220,000	–	1.04%	–
PACB	New	PACIFIC BIOSCIENCES CALIF IN	$2,111,000	–	300,000	–	1.01%	–
AGN	New	ALLERGAN PLC	$1,964,000	–	8,500	–	0.94%	–
CYNA	New	CYNAPSUS THERAPEUTICS INC	$1,933,000	–	115,400	–	0.93%	–
NBIX	New	NEUROCRINE BIOSCIENCES INC	$1,909,000	–	42,000	–	0.92%	–
PGNX	New	PROGENICS PHARMACEUTICALS IN	$1,894,000	–	448,885	–	0.91%	–
RTRX	New	RETROPHIN INC	$1,759,000	–	98,788	–	0.84%	–
	New	ESSA PHARMA INC	$1,754,000	–	570,232	–	0.84%	–
RIGL	New	RIGEL PHARMACEUTICALS INC	$1,667,000	–	747,748	–	0.80%	–
ATRC	New	ATRICURE INC	$1,596,000	–	112,923	–	0.77%	–
SRPT	New	SAREPTA THERAPEUTICS INCcall	$1,526,000	–	80,000	–	0.73%	–
WBMD	New	WEBMD HEALTH CORP	$1,453,000	–	25,000	–	0.70%	–
CYTK	New	CYTOKINETICS INC	$1,338,000	–	140,969	–	0.64%	–
SGY	New	STONE ENERGY CORPput	$1,304,000	–	108,100	–	0.63%	–
GHDX	New	GENOMIC HEALTH INC	$1,264,000	–	48,800	–	0.61%	–
ASMB	New	ASSEMBLY BIOSCIENCES INC	$1,251,000	–	225,444	–	0.60%	–
RXDX	New	IGNYTA INC	$1,245,000	–	229,748	–	0.60%	–
ALIM	New	ALIMERA SCIENCES INC	$1,198,000	–	974,318	–	0.58%	–
OLED	New	UNIVERSAL DISPLAY CORP	$1,017,000	–	15,000	–	0.49%	–
RPTP	New	RAPTOR PHARMACEUTICAL CORP	$938,000	–	174,708	–	0.45%	–
ONS	New	ONCOBIOLOGICS INC	$828,000	–	243,391	–	0.40%	–
SVA	New	SINOVAC BIOTECH LTD	$786,000	–	132,503	–	0.38%	–
MRTX	New	MIRATI THERAPEUTICS INC	$683,000	–	125,000	–	0.33%	–
IRWD	New	IRONWOOD PHARMACEUTICALS INC	$654,000	–	50,000	–	0.31%	–
BEAT	New	BIOTELEMETRY INC	$564,000	–	34,630	–	0.27%	–
AKTX	New	AKARI THERAPEUTICS PLCsponsored adr	$446,000	–	33,077	–	0.21%	–
CDNA	New	CAREDX INC	$279,000	–	64,627	–	0.13%	–
TROV	New	TROVAGENE INCput	$236,000	–	52,000	–	0.11%	–
DXTRQ	New	DEXTERA SURGICAL INC	$232,000	–	128,958	–	0.11%	–
CYTR	New	CYTRX CORPput	$223,000	–	100,000	–	0.11%	–
AUDC	New	AUDIOCODES LTDord	$189,000	–	45,035	–	0.09%	–
RLYP	New	RELYPSA INCcall	$185,000	–	10,000	–	0.09%	–
CBMX	New	COMBIMATRIX CORPORATION	$136,000	–	47,431	–	0.06%	–
IMMU	New	IMMUNOMEDICS INCcall	$136,000	–	58,600	–	0.06%	–
MNKD	New	MANNKIND CORPput	$104,000	–	90,000	–	0.05%	–
CEMI	New	CHEMBIO DIAGNOSTICS INC	$100,000	–	12,180	–	0.05%	–
ONSIW	New	ONCOBIOLOGICS INC*w exp 02/18/201	$45,000	–	96,833	–	0.02%	–
ONSIZ	New	ONCOBIOLOGICS INC*w exp 05/18/201	$44,000	–	96,833	–	0.02%	–
PTX	New	PERNIX THERAPEUTICS HLDGS INput	$28,000	–	62,800	–	0.01%	–

Q4 2015

			Value		Shares		↓ Weighting
AXDX	Exit	ACCELERATE DIAGNOSTICS INCput	$0	–	-15,000	–	-0.14%	–
KIN	Exit	KINDRED BIOSCIENCES	$0	–	-50,000	–	-0.15%	–
ARWR	Exit	ARROWHEAD RESH CORPput	$0	–	-50,000	–	-0.17%	–
ZSAN	Exit	ZOSANO PHARMA	$0	–	-73,826	–	-0.17%	–
ONVO	Exit	ORGANOVO HLDGS INCput	$0	–	-120,000	–	-0.19%	–
CEMP	Exit	CEMPRA	$0	–	-15,000	–	-0.24%	–
ABEO	Exit	ABEONA THERAPEUTICS	$0	–	-111,342	–	-0.26%	–
HSGX	Exit	HISTOGENICS	$0	–	-123,249	–	-0.28%	–
RIGL	Exit	RIGEL PHARMACEUTICALS	$0	–	-200,000	–	-0.29%	–
CRDC	Exit	CARDICA	$0	–	-1,849,436	–	-0.29%	–
CDTX	Exit	CIDARA THERAPEUTICS	$0	–	-59,127	–	-0.44%	–
CRME	Exit	CARDIOME PHARMA	$0	–	-92,397	–	-0.45%	–
CLDN	Exit	CELLADON	$0	–	-819,710	–	-0.50%	–
EWA	Exit	ISHARESput	$0	–	-50,000	–	-0.52%	–
AGRX	Exit	AGILE THERAPEUTICS	$0	–	-141,309	–	-0.55%	–
CBMX	Exit	COMBIMATRIX CORPORATION	$0	–	-893,644	–	-0.58%	–
SRPT	Exit	SAREPTA THERAPEUTICS	$0	–	-31,744	–	-0.59%	–
FLKS	Exit	FLEX PHARMA	$0	–	-88,716	–	-0.62%	–
AUPH	Exit	AURINIA PHARMACEUTICALS	$0	–	-377,427	–	-0.62%	–
BIOD	Exit	BIODEL	$0	–	-2,548,830	–	-0.65%	–
BDSI	Exit	BIODELIVERY SCIENCES INTL	$0	–	-212,100	–	-0.68%	–
CLVS	Exit	CLOVIS ONCOLOGY INCcall	$0	–	-15,000	–	-0.80%	–
CUTR	Exit	CUTERA	$0	–	-116,921	–	-0.88%	–
TAST	Exit	CARROLS RESTAURANT GROUP	$0	–	-128,643	–	-0.89%	–
ZFGN	Exit	ZAFGEN	$0	–	-51,519	–	-0.95%	–
	Exit	ESSA PHARMA INC	$0	–	-288,400	–	-1.04%	–
EPZM	Exit	EPIZYME	$0	–	-140,000	–	-1.04%	–
AXGT	Exit	AXOVANT SCIENCES	$0	–	-140,000	–	-1.05%	–
ALIM	Exit	ALIMERA SCIENCES	$0	–	-974,318	–	-1.25%	–
ARRY	Exit	ARRAY BIOPHARMA	$0	–	-480,020	–	-1.27%	–
AGEN	Exit	AGENUS	$0	–	-510,000	–	-1.36%	–
OXFD	Exit	OXFORD IMMUNOTEC GLOBAL PLC	$0	–	-184,746	–	-1.44%	–
SRNE	Exit	SORRENTO THERAPEUTICS	$0	–	-300,000	–	-1.46%	–
SGNT	Exit	SAGENT PHARMACEUTICALS	$0	–	-182,618	–	-1.62%	–
BBW	Exit	BUILD A BEAR WORKSHOP	$0	–	-152,876	–	-1.67%	–
AGTC	Exit	APPLIED GENETIC TECHNOL	$0	–	-221,138	–	-1.68%	–
IMMU	Exit	IMMUNOMEDICS	$0	–	-1,711,067	–	-1.70%	–
	Exit	SPECTRANETICS CORPmtnf 2.625% 6/0	$0	–	-4,000,000	–	-1.75%	–
IRIX	Exit	IRIDEX	$0	–	-397,196	–	-1.75%	–
SPNC	Exit	SPECTRANETICS CORP	$0	–	-260,000	–	-1.77%	–
BCRX	Exit	BIOCRYST PHARMACEUTICALS	$0	–	-271,399	–	-1.79%	–
WBMD	Exit	WEBMD HEALTH	$0	–	-79,702	–	-1.84%	–
CASM	Exit	CAS MED SYS INC	$0	–	-2,547,299	–	-1.84%	–
NBRV	Exit	NABRIVA THERAPEUTICS AGspons adr	$0	–	-351,261	–	-1.93%	–
LJPC	Exit	LA JOLLA PHARMACEUTICAL CO	$0	–	-122,222	–	-1.97%	–
INNL	Exit	INNOCOLL AGspons adr	$0	–	-273,981	–	-1.99%	–
PTX	Exit	PERNIX THERAPEUTICS HLDGS	$0	–	-1,108,719	–	-2.03%	–
RRM	Exit	RR MEDIA LTD	$0	–	-469,350	–	-2.23%	–
VCYT	Exit	VERACYTE	$0	–	-905,000	–	-2.46%	–
LXRX	Exit	LEXICON PHARMACEUTICALS	$0	–	-400,000	–	-2.49%	–
XBI	Exit	SPDR SERIES TRUSTput	$0	–	-70,000	–	-2.52%	–
CYNA	Exit	CYNAPSUS THERAPEUTICS INC	$0	–	-313,524	–	-2.94%	–
BEAT	Exit	BIOTELEMETRY	$0	–	-450,000	–	-3.19%	–
LBIO	Exit	LION BIOTECHNOLOGIES	$0	–	-1,314,959	–	-4.38%	–
IWM	Exit	ISHARES TRput	$0	–	-70,000	–	-4.43%	–
ASND	Exit	ASCENDIS PHARMA A Sspons adr	$0	–	-469,893	–	-4.82%	–
	Exit	NEURODERM LTD	$0	–	-496,630	–	-5.94%	–
EXEL	Exit	EXELIXIS	$0	–	-1,880,004	–	-6.11%	–
FOLD	Exit	AMICUS THERAPEUTICS	$0	–	-1,404,667	–	-11.38%	–

Q3 2015

			Value		Shares		↓ Weighting
FOLD	Sell	AMICUS THERAPEUTICS	$19,651,000	-21.8%	1,404,667	-20.9%	11.38%	-26.7%
EXEL	New	EXELIXIS	$10,547,000	–	1,880,004	–	6.11%	–
	Buy	NEURODERM LTD	$10,265,000	+122.9%	496,630	+65.5%	5.94%	+108.7%
ASND	Buy	ASCENDIS PHARMA A Sspons adr	$8,317,000	+11.5%	469,893	+11.4%	4.82%	+4.4%
LBIO	Buy	LION BIOTECHNOLOGIES	$7,574,000	-6.8%	1,314,959	+48.4%	4.38%	-12.7%
BEAT	Sell	BIOTELEMETRY	$5,508,000	-11.5%	450,000	-31.8%	3.19%	-17.1%
CYNA	Buy	CYNAPSUS THERAPEUTICS INC	$5,070,000	+83.5%	313,524	+84.8%	2.94%	+71.8%
XBI	New	SPDR SERIES TRUSTput	$4,357,000	–	70,000	–	2.52%	–
LXRX	New	LEXICON PHARMACEUTICALS	$4,296,000	–	400,000	–	2.49%	–
VCYT	Buy	VERACYTE	$4,244,000	-52.3%	905,000	+13.4%	2.46%	-55.3%
RRM	Buy	RR MEDIA LTD	$3,849,000	+24.8%	469,350	+14.5%	2.23%	+16.9%
PTX	New	PERNIX THERAPEUTICS HLDGS	$3,504,000	–	1,108,719	–	2.03%	–
INNL	Buy	INNOCOLL AGspons adr	$3,430,000	-1.2%	273,981	+15.5%	1.99%	-7.5%
LJPC	New	LA JOLLA PHARMACEUTICAL CO	$3,397,000	–	122,222	–	1.97%	–
NBRV	New	NABRIVA THERAPEUTICS AGspons adr	$3,337,000	–	351,261	–	1.93%	–
CASM	Buy	CAS MED SYS INC	$3,184,000	+5.6%	2,547,299	+8.1%	1.84%	-1.1%
WBMD	New	WEBMD HEALTH	$3,175,000	–	79,702	–	1.84%	–
BCRX	New	BIOCRYST PHARMACEUTICALS	$3,094,000	–	271,399	–	1.79%	–
SPNC	Buy	SPECTRANETICS CORP	$3,065,000	-46.7%	260,000	+4.0%	1.77%	-50.1%
IRIX	Buy	IRIDEX	$3,023,000	+17.3%	397,196	+27.1%	1.75%	+9.8%
	New	SPECTRANETICS CORPmtnf 2.625% 6/0	$3,020,000	–	4,000,000	–	1.75%	–
IMMU	New	IMMUNOMEDICS	$2,943,000	–	1,711,067	–	1.70%	–
AGTC	Sell	APPLIED GENETIC TECHNOL	$2,906,000	-74.7%	221,138	-70.4%	1.68%	-76.3%
BBW	Sell	BUILD A BEAR WORKSHOP	$2,888,000	-9.7%	152,876	-23.6%	1.67%	-15.4%
SGNT	Buy	SAGENT PHARMACEUTICALS	$2,800,000	+311.2%	182,618	+552.2%	1.62%	+285.0%
SRNE	Buy	SORRENTO THERAPEUTICS	$2,517,000	-32.8%	300,000	+41.2%	1.46%	-37.0%
OXFD	Sell	OXFORD IMMUNOTEC GLOBAL PLC	$2,494,000	-8.9%	184,746	-6.5%	1.44%	-14.7%
AGEN	Buy	AGENUS	$2,346,000	-38.8%	510,000	+14.9%	1.36%	-42.7%
ARRY	New	ARRAY BIOPHARMA	$2,189,000	–	480,020	–	1.27%	–
AXGT	Sell	AXOVANT SCIENCES	$1,809,000	-47.8%	140,000	-17.6%	1.05%	-51.1%
EPZM	New	EPIZYME	$1,800,000	–	140,000	–	1.04%	–
	New	ESSA PHARMA INC	$1,797,000	–	288,400	–	1.04%	–
ZFGN	Sell	ZAFGEN	$1,646,000	-10.2%	51,519	-2.6%	0.95%	-15.9%
TAST	New	CARROLS RESTAURANT GROUP	$1,531,000	–	128,643	–	0.89%	–
CUTR	Buy	CUTERA	$1,529,000	+31.7%	116,921	+55.9%	0.88%	+23.3%
CLVS	New	CLOVIS ONCOLOGY INCcall	$1,379,000	–	15,000	–	0.80%	–
BDSI	New	BIODELIVERY SCIENCES INTL	$1,179,000	–	212,100	–	0.68%	–
BIOD	Sell	BIODEL	$1,121,000	-62.3%	2,548,830	-11.7%	0.65%	-64.7%
AUPH	Sell	AURINIA PHARMACEUTICALS	$1,072,000	-32.4%	377,427	-28.1%	0.62%	-36.6%
SRPT	New	SAREPTA THERAPEUTICS	$1,019,000	–	31,744	–	0.59%	–
CBMX	Buy	COMBIMATRIX CORPORATION	$1,001,000	-29.4%	893,644	+1.5%	0.58%	-33.8%
AGRX	Buy	AGILE THERAPEUTICS	$952,000	-13.8%	141,309	+9.9%	0.55%	-19.3%
EWA	New	ISHARESput	$896,000	–	50,000	–	0.52%	–
CLDN	New	CELLADON	$861,000	–	819,710	–	0.50%	–
CRME	New	CARDIOME PHARMA	$780,000	–	92,397	–	0.45%	–
CDTX	Sell	CIDARA THERAPEUTICS	$752,000	-58.7%	59,127	-54.5%	0.44%	-61.4%
RIGL	New	RIGEL PHARMACEUTICALS	$494,000	–	200,000	–	0.29%	–
ABEO	New	ABEONA THERAPEUTICS	$451,000	–	111,342	–	0.26%	–
ONVO	New	ORGANOVO HLDGS INCput	$322,000	–	120,000	–	0.19%	–
ZSAN	Sell	ZOSANO PHARMA	$292,000	-53.8%	73,826	-15.3%	0.17%	-56.8%
ARWR	New	ARROWHEAD RESH CORPput	$288,000	–	50,000	–	0.17%	–
AXDX	New	ACCELERATE DIAGNOSTICS INCput	$243,000	–	15,000	–	0.14%	–
SSH	Exit	SUNSHINE HEART INCput	$0	–	-60,000	–	-0.13%	–
MOLGY	Exit	MOL GLOBAL SPONSORED ADRspons adr	$0	–	-147,912	–	-0.14%	–
SMLR	Exit	SEMLER SCIENTIFIC	$0	–	-80,935	–	-0.16%	–
FOMX	Exit	FOAMIX PHARMACEUTICALS SHS	$0	–	-30,000	–	-0.19%	–
	Exit	ALCOBRA SHS	$0	–	-70,039	–	-0.28%	–
ADAP	Exit	ADAPTIMMUNE THERAPEUTICS PLCspons adr	$0	–	-30,000	–	-0.34%	–
CEMI	Exit	CHEMBIO DIAGNOSTICS	$0	–	-130,000	–	-0.39%	–
VSAR	Exit	VERSARTIS	$0	–	-50,000	–	-0.47%	–
AWAY	Exit	HOMEAWAY	$0	–	-25,000	–	-0.48%	–
HUM	Exit	HUMANA	$0	–	-6,000	–	-0.71%	–
OTIC	Exit	OTONOMY	$0	–	-53,400	–	-0.76%	–
EGOV	Exit	NIC	$0	–	-70,000	–	-0.79%	–
COLL	Exit	COLLEGIUM PHARMACEUTICAL	$0	–	-130,000	–	-1.43%	–
ONTY	Exit	ONCOTHYREON	$0	–	-670,000	–	-1.55%	–
IG	Exit	IGI LABS	$0	–	-462,944	–	-1.80%	–
LMAT	Exit	LEMAITRE VASCULAR	$0	–	-250,000	–	-1.86%	–
AVID	Exit	AVID TECHNOLOGY	$0	–	-230,000	–	-1.90%	–

Q2 2015

			Value		Shares		↓ Weighting
FOLD	New	AMICUS THERAPEUTICS	$25,116,000	–	1,775,000	–	15.53%	–
AGTC	New	APPLIED GENETIC TECHNOL	$11,474,000	–	748,000	–	7.09%	–
VCYT	New	VERACYTE	$8,891,000	–	798,100	–	5.50%	–
IWM	New	ISHARES TRput	$8,739,000	–	70,000	–	5.40%	–
LBIO	New	LION BIOTECHNOLOGIES	$8,125,000	–	886,000	–	5.02%	–
ASND	New	ASCENDIS PHARMA A Sspons adr	$7,458,000	–	421,851	–	4.61%	–
BEAT	New	BIOTELEMETRY	$6,224,000	–	660,000	–	3.85%	–
SPNC	New	SPECTRANETICS	$5,753,000	–	250,000	–	3.56%	–
	New	NEURODERM ORD SHS	$4,605,000	–	300,000	–	2.85%	–
ALIM	New	ALIMERA SCIENCES	$4,492,000	–	974,318	–	2.78%	–
AGEN	New	AGENUS	$3,831,000	–	443,868	–	2.37%	–
SRNE	New	SORRENTO THERAPEUTICS	$3,743,000	–	212,402	–	2.31%	–
INNL	New	INNOCOLL AG SPONSORED ADRspons adr	$3,472,000	–	237,287	–	2.15%	–
AXGT	New	AXOVANT SCIENCES	$3,465,000	–	170,000	–	2.14%	–
BBW	New	BUILD A BEAR WORKSHOP	$3,198,000	–	200,000	–	1.98%	–
RRM	New	RR MEDIA SHS	$3,083,000	–	410,000	–	1.91%	–
AVID	New	AVID TECHNOLOGY	$3,068,000	–	230,000	–	1.90%	–
CASM	New	CAS MED SYS PAR $0.004	$3,015,000	–	2,355,355	–	1.86%	–
LMAT	New	LEMAITRE VASCULAR	$3,015,000	–	250,000	–	1.86%	–
BIOD	New	BIODEL	$2,973,000	–	2,886,731	–	1.84%	–
IG	New	IGI LABS	$2,917,000	–	462,944	–	1.80%	–
CYNA	New	CYNAPSUS THERAPEUTICS INC	$2,763,000	–	169,616	–	1.71%	–
OXFD	New	OXFORD IMMUNOTEC GLOBAL PLC	$2,738,000	–	197,680	–	1.69%	–
IRIX	New	IRIDEX	$2,578,000	–	312,450	–	1.59%	–
ONTY	New	ONCOTHYREON	$2,506,000	–	670,000	–	1.55%	–
COLL	New	COLLEGIUM PHARMACEUTICAL	$2,319,000	–	130,000	–	1.43%	–
ZFGN	New	ZAFGEN	$1,832,000	–	52,900	–	1.13%	–
CDTX	New	CIDARA THERAPEUTICS	$1,823,000	–	130,000	–	1.13%	–
AUPH	New	AURINIA PHARMACEUTICALS	$1,585,000	–	524,751	–	0.98%	–
FLKS	New	FLEX PHARMA	$1,526,000	–	88,716	–	0.94%	–
CBMX	New	COMBIMATRIX CORPORATION	$1,417,000	–	880,244	–	0.88%	–
EGOV	New	NIC	$1,280,000	–	70,000	–	0.79%	–
OTIC	New	OTONOMY	$1,228,000	–	53,400	–	0.76%	–
CUTR	New	CUTERA	$1,161,000	–	75,000	–	0.72%	–
HUM	New	HUMANA	$1,148,000	–	6,000	–	0.71%	–
AGRX	New	AGILE THERAPEUTICS	$1,104,000	–	128,566	–	0.68%	–
CRDC	New	CARDICA	$923,000	–	1,849,436	–	0.57%	–
HSGX	New	HISTOGENICS	$796,000	–	123,249	–	0.49%	–
AWAY	New	HOMEAWAY	$778,000	–	25,000	–	0.48%	–
VSAR	New	VERSARTIS	$761,000	–	50,000	–	0.47%	–
SGNT	New	SAGENT PHARMACEUTICALS	$681,000	–	28,000	–	0.42%	–
CEMI	New	CHEMBIO DIAGNOSTICS	$638,000	–	130,000	–	0.39%	–
ZSAN	New	ZOSANO PHARMA	$632,000	–	87,189	–	0.39%	–
ADAP	New	ADAPTIMMUNE THERAPEUTICS PLCspons adr	$550,000	–	30,000	–	0.34%	–
CEMP	New	CEMPRA	$515,000	–	15,000	–	0.32%	–
	New	ALCOBRA SHS	$458,000	–	70,039	–	0.28%	–
KIN	New	KINDRED BIOSCIENCES	$341,000	–	50,000	–	0.21%	–
FOMX	New	FOAMIX PHARMACEUTICALS SHS	$308,000	–	30,000	–	0.19%	–
SMLR	New	SEMLER SCIENTIFIC	$267,000	–	80,935	–	0.16%	–
MOLGY	New	MOL GLOBAL SPONSORED ADRspons adr	$226,000	–	147,912	–	0.14%	–
SSH	New	SUNSHINE HEART INCput	$207,000	–	60,000	–	0.13%	–

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