$701 Million is the total value of SPHERA FUNDS MANAGEMENT LTD.'s 131 reported holdings in Q3 2017. The portfolio turnover from Q2 2017 to Q3 2017 was 97.2% .
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| XBI | New | SPDR SERIES TRUSTput | $121,198,000 | – | 1,400,000 | +100.0% | 17.29% | – |
| CELG | Buy | CELGENE CORP | $40,101,000 | +23.5% | 275,000 | +10.0% | 5.72% | +3.7% |
| BIIB | Buy | BIOGEN INC | $32,878,000 | +34.6% | 105,000 | +16.7% | 4.69% | +13.1% |
| MRK | Buy | MERCK & CO INC | $27,213,000 | +32.7% | 425,000 | +32.8% | 3.88% | +11.5% |
| SRPT | Buy | SAREPTA THERAPEUTICS INC | $17,463,000 | +35.2% | 384,997 | +0.5% | 2.49% | +13.6% |
| CELJF | New | CELLCOM ISRAEL LTD | $14,301,000 | – | 1,535,988 | +100.0% | 2.04% | – |
| SHPG | Buy | SHIRE PLCsponsored adr | $13,247,000 | +17.0% | 86,500 | +26.3% | 1.89% | -1.7% |
| CLVS | Buy | CLOVIS ONCOLOGY INC | $13,019,000 | +49.5% | 158,000 | +69.9% | 1.86% | +25.6% |
| AGN | New | ALLERGAN PLC | $12,297,000 | – | 60,000 | +100.0% | 1.75% | – |
| TSRO | Buy | TESARO INC | $10,328,000 | +34.3% | 80,000 | +45.5% | 1.47% | +12.8% |
| CLLS | Buy | CELLECTIS S Asponsored ads | $9,922,000 | +88.6% | 348,736 | +71.1% | 1.42% | +58.4% |
| NICE | Buy | NICE LTDsponsored adr | $8,876,000 | +32.6% | 109,159 | +28.3% | 1.27% | +11.3% |
| BMRN | Buy | BIOMARIN PHARMACEUTICAL INC | $7,911,000 | +16.1% | 85,000 | +13.3% | 1.13% | -2.4% |
| PTLA | Buy | PORTOLA PHARMACEUTICALS INC | $7,834,000 | +248.6% | 145,000 | +262.5% | 1.12% | +192.7% |
| ALDX | Buy | ALDEYRA THERAPEUTICS INC | $7,518,000 | +82.6% | 1,044,131 | +19.2% | 1.07% | +53.5% |
| TEVA | New | TEVA PHARMACEUTICAL INDS LTDsponsored adr | $7,040,000 | – | 400,000 | +100.0% | 1.00% | – |
| SRPT | New | SAREPTA THERAPEUTICS INCcall | $6,804,000 | – | 150,000 | +100.0% | 0.97% | – |
| RETA | New | REATA PHARMACEUTICALS INCcl a | $6,376,000 | – | 205,000 | +100.0% | 0.91% | – |
| FOLD | Buy | AMICUS THERAPEUTICS INC | $6,334,000 | +57.2% | 420,000 | +5.0% | 0.90% | +32.2% |
| EIGR | Buy | EIGER BIOPHARMACEUTICALS INC | $5,723,000 | +88.0% | 520,269 | +35.0% | 0.82% | +58.0% |
| RXDX | Buy | IGNYTA INC | $5,672,000 | +37.0% | 459,300 | +14.8% | 0.81% | +15.1% |
| GOOGL | Buy | ALPHABET INCcap stk cl a | $5,615,000 | +39.0% | 5,767 | +32.7% | 0.80% | +16.8% |
| NBIX | Buy | NEUROCRINE BIOSCIENCES INC | $5,331,000 | +86.9% | 87,000 | +40.3% | 0.76% | +56.9% |
| LJPC | Buy | LA JOLLA PHARMACEUTICAL CO | $5,217,000 | +40.2% | 150,000 | +20.0% | 0.74% | +17.7% |
| ZGNX | New | ZOGENIX INC | $5,082,000 | – | 145,000 | +100.0% | 0.72% | – |
| NERV | Buy | MINERVA NEUROSCIENCES INC | $4,750,000 | +13.3% | 625,000 | +31.9% | 0.68% | -4.8% |
| MYL | New | MYLAN N Vcall | $4,706,000 | – | 150,000 | +100.0% | 0.67% | – |
| SPNS | Buy | SAPIENS INTL CORP N V | $4,650,000 | +182.2% | 354,866 | +140.9% | 0.66% | +136.8% |
| INSM | New | INSMED INC | $4,213,000 | – | 135,000 | +100.0% | 0.60% | – |
| GLD | New | SPDR GOLD TRUST | $4,035,000 | – | 33,190 | +100.0% | 0.58% | – |
| PRTA | Buy | PROTHENA CORP PLC | $3,886,000 | +79.5% | 60,000 | +50.0% | 0.55% | +50.5% |
| MGNX | Buy | MACROGENICS INC | $3,857,000 | +171.2% | 208,700 | +157.0% | 0.55% | +127.3% |
| CTMX | Buy | CYTOMX THERAPEUTICS INC | $3,816,000 | +23.1% | 210,000 | +5.0% | 0.54% | +3.2% |
| KDMN | New | KADMON HLDGS INC | $3,685,000 | – | 1,100,000 | +100.0% | 0.53% | – |
| EDGE | Buy | EDGE THERAPEUTICS INC | $3,581,000 | +132.7% | 333,737 | +122.5% | 0.51% | +95.8% |
| CYTK | Buy | CYTOKINETICS INC | $3,306,000 | +25.3% | 227,990 | +4.6% | 0.47% | +5.4% |
| VRTX | New | VERTEX PHARMACEUTICALS INC | $3,166,000 | – | 20,823 | +100.0% | 0.45% | – |
| PANW | New | PALO ALTO NETWORKS INC | $2,998,000 | – | 20,805 | +100.0% | 0.43% | – |
| ANAB | New | ANAPTYSBIO INC | $2,796,000 | – | 80,000 | +100.0% | 0.40% | – |
| CMTA | New | CLEMENTIA PHARMACEUTICALS IN | $2,753,000 | – | 163,000 | +100.0% | 0.39% | – |
| CTIC | New | CTI BIOPHARMA CORP | $2,659,000 | – | 833,633 | +100.0% | 0.38% | – |
| SMMT | Buy | SUMMIT THERAPEUTICS PLCspons ads | $2,654,000 | +70.0% | 212,018 | +49.3% | 0.38% | +43.0% |
| PRQR | Buy | PROQR THRAPEUTICS N V | $2,571,000 | +49.8% | 530,000 | +60.6% | 0.37% | +25.7% |
| CMCSA | New | COMCAST CORP NEWcl a | $2,554,000 | – | 66,360 | +100.0% | 0.36% | – |
| FLKS | New | FLEX PHARMA INC | $2,341,000 | – | 141,300 | +100.0% | 0.33% | – |
| ALBO | Buy | ALBIREO PHARMA INC | $2,274,000 | +6.6% | 108,526 | +4.8% | 0.32% | -10.5% |
| CTSH | New | COGNIZANT TECHNOLOGY SOLUTIOcl a | $2,239,000 | – | 30,866 | +100.0% | 0.32% | – |
| ORLY | New | O REILLY AUTOMOTIVE INC NEWcall | $2,154,000 | – | 10,000 | +100.0% | 0.31% | – |
| OBSV | Buy | OBSEVA SA | $2,118,000 | +7.0% | 260,197 | +12.4% | 0.30% | -10.1% |
| AAP | New | ADVANCE AUTO PARTS INCcall | $2,083,000 | – | 21,000 | +100.0% | 0.30% | – |
| AXGT | New | AXOVANT SCIENCES LTDput | $2,064,000 | – | 300,000 | +100.0% | 0.29% | – |
| EVOK | Buy | EVOKE PHARMA INC | $1,907,000 | +49.0% | 571,022 | +14.2% | 0.27% | +25.3% |
| NITE | New | NIGHTSTAR THERAPEUTICS PLCadr | $1,728,000 | – | 90,000 | +100.0% | 0.25% | – |
| VTGN | Buy | VISTAGEN THERAPEUTICS INC | $1,693,000 | +66.5% | 1,058,386 | +94.5% | 0.24% | +39.9% |
| FPRX | New | FIVE PRIME THERAPEUTICS INC | $1,636,000 | – | 40,000 | +100.0% | 0.23% | – |
| CYTK | New | CYTOKINETICS INCcall | $1,450,000 | – | 100,000 | +100.0% | 0.21% | – |
| DCPH | New | DECIPHERA PHARMACEUTICALS IN | $1,424,000 | – | 75,000 | +100.0% | 0.20% | – |
| ACHN | New | ACHILLION PHARMACEUTICALS IN | $1,347,000 | – | 300,000 | +100.0% | 0.19% | – |
| TEVA | New | TEVA PHARMACEUTICAL INDS LTDput | $1,267,000 | – | 72,000 | +100.0% | 0.18% | – |
| AXGT | New | AXOVANT SCIENCES LTDcall | $1,238,000 | – | 180,000 | +100.0% | 0.18% | – |
| AQXP | Buy | AQUINOX PHARMACEUTICALS INC | $1,072,000 | +22.7% | 75,535 | +21.7% | 0.15% | +3.4% |
| KRNT | Buy | KORNIT DIGITAL LTD | $1,025,000 | -7.6% | 67,006 | +16.9% | 0.15% | -22.3% |
| NCNA | New | NUCANA PLCsponsored adr | $919,000 | – | 50,000 | +100.0% | 0.13% | – |
| VKTX | New | VIKING THERAPEUTICS INC | $554,000 | – | 290,000 | +100.0% | 0.08% | – |
| SAGE | Buy | SAGE THERAPEUTICS INC | $381,000 | -4.3% | 6,118 | +22.4% | 0.05% | -20.6% |
| SERV | Buy | SERVICEMASTER GLOBAL HLDGS I | $374,000 | +90.8% | 8,000 | +60.0% | 0.05% | +60.6% |
| ORLY | New | O REILLY AUTOMOTIVE INC NEW | $366,000 | – | 1,700 | +100.0% | 0.05% | – |
| AAP | New | ADVANCE AUTO PARTS INC | $266,000 | – | 2,686 | +100.0% | 0.04% | – |
| ECL | Buy | ECOLAB INC | $257,000 | +93.2% | 2,000 | +100.0% | 0.04% | +60.9% |
| SAGE | New | SAGE THERAPEUTICS INCput | $150,000 | – | 2,400 | +100.0% | 0.02% | – |
| ATHX | New | ATHERSYS INC | $2,000 | – | 773 | +100.0% | 0.00% | – |
Other managers
Other managers that, in addition to the filing manager(s), that filed the EDGAR filing(s):
Original filings
The following EDGAR filing(s) were analyzed to create this report:
- View 13F-HR/A filed 2017-11-27
Top long-term holdings
| Name | Quarters owned | Latest quarter owned | Max weighting |
|---|---|---|---|
| TEVA PHARMACEUTICAL-SP ADR | 36 | Q3 2023 | 8.4% |
| MERCK & CO INC NEW | 35 | Q3 2023 | 8.4% |
| NICE Systems Ltd | 27 | Q3 2023 | 4.4% |
| BIOGEN INC | 26 | Q3 2023 | 6.7% |
| AMICUS THERAPEUTICS INC | 26 | Q2 2022 | 4.3% |
| PFIZER INC | 25 | Q3 2023 | 9.2% |
| SAREPTA THERAPEUTICS INC | 25 | Q3 2023 | 3.2% |
| JOHNSON & JOHNSON | 24 | Q3 2023 | 8.0% |
| UNIQURE NV | 23 | Q3 2023 | 1.2% |
| SYNDAX PHARMACEUTICALS INC | 22 | Q3 2023 | 3.9% |
View SPHERA FUNDS MANAGEMENT LTD.'s complete holdings history.
Latest significant ownerships (13-D/G)
| Filed | Shares | Percentage | |
|---|---|---|---|
| Cyclacel Pharmaceuticals, Inc. | February 06, 2023 | 250,000 | 2.0% |
| Altimmune, Inc. | February 14, 2022 | 1,244,241 | 3.1% |
| Allot Ltd. | February 16, 2021 | 1,129,054 | 3.2% |
| Larimar Therapeutics, Inc. | February 16, 2021 | ? | ? |
| Neos Therapeutics, Inc. | February 16, 2021 | ? | ? |
| Orgenesis Inc. | February 16, 2021 | 525,216 | 0.0% |
| Sio Gene Therapies Inc. | February 16, 2021 | ? | ? |
| X4 Pharmaceuticals, Inc | February 16, 2021 | 250,000 | 0.0% |
| Axovant Gene Therapies Ltd. | February 25, 2020 | 2,931,017 | 8.0% |
| Axovant Gene Therapies Ltd. | February 11, 2020 | 398,540 | 1.8% |
View SPHERA FUNDS MANAGEMENT LTD.'s complete significant-ownership history.
Latest filings
| Type | Filed |
|---|---|
| 13F-HR | 2024-05-15 |
| 13F-HR/A | 2024-02-15 |
| 13F-HR | 2024-02-14 |
| SC 13G | 2024-02-08 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| 13F-HR | 2023-11-14 |
| SC 13G | 2023-10-10 |
View SPHERA FUNDS MANAGEMENT LTD.'s complete filings history.
All filings
- Holdings (13F-HR)
- Significant ownership (13-D/G)
- Insider transactions (4, 5, 6)
- Events (8-K)
- Shareholder votes (proxy)
View complete filings history.