$961 Million is the total value of SPHERA FUNDS MANAGEMENT LTD.'s 148 reported holdings in Q1 2015. The portfolio turnover from Q4 2014 to Q1 2015 was 59.3% .
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| Sell | TEVA PHARMACEUTICAL INDS LTDcall | $21,805,000 | +1110.7% | 3,500 | -99.2% | 2.27% | +639.4% | |
| ORA | Sell | ORMAT TECHNOLOGIES INC | $12,054,000 | +465.4% | 80,092 | -74.1% | 1.26% | +245.7% |
| NVS | Sell | NOVARTIS A Gsponsored adr | $9,861,000 | -75.9% | 100,000 | -77.3% | 1.03% | -85.2% |
| VRX | Sell | VALEANT PHARMACEUTICALS INTL | $9,087,000 | -35.6% | 45,750 | -53.6% | 0.95% | -60.6% |
| UTHR | Sell | UNITED THERAPEUTICS CORP DEL | $8,422,000 | -11.9% | 48,840 | -33.9% | 0.88% | -46.2% |
| VRNT | Sell | VERINT SYS INC | $7,574,000 | -11.1% | 122,304 | -16.3% | 0.79% | -45.6% |
| SHPG | Sell | SHIRE PLCsponsored adr | $7,229,000 | -54.5% | 134,751 | -40.0% | 0.75% | -72.2% |
| ARRY | Sell | ARRAY BIOPHARMA INC | $6,809,000 | +47.8% | 923,922 | -5.1% | 0.71% | -9.7% |
| BMY | Sell | BRISTOL MYERS SQUIBB CO | $6,450,000 | -27.2% | 100,000 | -33.3% | 0.67% | -55.5% |
| FWP | Sell | FORWARD PHARMA A/Ssponsored adr | $5,098,000 | +22.4% | 180,000 | -10.0% | 0.53% | -25.2% |
| TW | Sell | TOWERS WATSON & COcl a | $5,063,000 | +5.6% | 38,300 | -9.6% | 0.53% | -35.5% |
| FOLD | Sell | AMICUS THERAPEUTICS INC | $4,896,000 | +7.0% | 450,000 | -18.2% | 0.51% | -34.6% |
| MDVN | Sell | MEDIVATION INC | $4,661,000 | -11.9% | 36,115 | -32.0% | 0.48% | -46.2% |
| PTCT | Sell | PTC THERAPEUTICS INC | $4,260,000 | -25.2% | 70,000 | -36.4% | 0.44% | -54.2% |
| BIIB | Sell | BIOGEN INC | $4,222,000 | -68.9% | 10,000 | -75.0% | 0.44% | -81.0% |
| KITE | Sell | KITE PHARMA INC | $3,805,000 | -40.5% | 65,970 | -40.6% | 0.40% | -63.7% |
| TJX | Sell | TJX COS INC NEW | $3,315,000 | -28.5% | 47,330 | -30.0% | 0.34% | -56.3% |
| SAGE | Sell | SAGE THERAPEUTICS INC | $3,301,000 | +13.1% | 65,724 | -17.6% | 0.34% | -30.8% |
| PBYI | Sell | PUMA BIOTECHNOLOGY INC | $3,257,000 | -15.2% | 13,796 | -32.0% | 0.34% | -48.2% |
| ORBK | Sell | ORBOTECH LTDord | $3,152,000 | -24.2% | 196,622 | -30.0% | 0.33% | -53.7% |
| AEGR | Sell | AEGERION PHARMACEUTICALS INC | $3,140,000 | -6.3% | 120,000 | -25.0% | 0.33% | -42.7% |
| RCPT | Sell | RECEPTOS INC | $2,886,000 | -21.5% | 17,500 | -41.7% | 0.30% | -52.1% |
| TRVN | Sell | TREVENA INC | $2,555,000 | -22.3% | 391,811 | -28.7% | 0.27% | -52.5% |
| QURE | Sell | UNIQURE NV | $2,491,000 | -0.1% | 102,415 | -39.2% | 0.26% | -39.1% |
| SNA | Sell | SNAP ON INC | $2,256,000 | -22.0% | 15,340 | -27.4% | 0.24% | -52.3% |
| SGMO | Sell | SANGAMO BIOSCIENCES INC | $2,195,000 | -27.8% | 140,000 | -30.0% | 0.23% | -55.8% |
| MRNS | Sell | MARINUS PHARMACEUTICALS INC | $1,920,000 | -37.9% | 213,533 | -27.3% | 0.20% | -62.0% |
| UNP | Sell | UNION PAC CORP | $1,894,000 | -38.1% | 17,489 | -31.9% | 0.20% | -62.2% |
| MGNX | Sell | MACROGENICS INC | $1,882,000 | -36.3% | 60,000 | -28.7% | 0.20% | -61.0% |
| TKAI | Sell | TOKAI PHARMACEUTICALS INC | $1,654,000 | -27.1% | 146,341 | -4.9% | 0.17% | -55.4% |
| Sell | MANNKIND CORPput | $1,560,000 | +35.1% | 3,000 | -99.0% | 0.16% | -17.8% | |
| GNVC | Sell | GENVEC INC | $1,559,000 | +30.5% | 528,325 | -5.4% | 0.16% | -20.6% |
| OCRX | Sell | OCERA THERAPEUTICS INC | $1,513,000 | -43.6% | 321,254 | -23.7% | 0.16% | -65.4% |
| MDGN | Sell | MEDGENICS INC | $1,411,000 | +23.9% | 175,000 | -22.2% | 0.15% | -24.2% |
| CBAY | Sell | CYMABAY THERAPEUTICS INC | $1,088,000 | -71.6% | 157,179 | -59.7% | 0.11% | -82.7% |
| ACHN | Sell | ACHILLION PHARMACEUTICALS IN | $646,000 | -58.0% | 65,538 | -47.8% | 0.07% | -74.4% |
| ADHD | Sell | ALCOBRA LTD | $1,000 | -99.3% | 200 | -99.5% | 0.00% | -100.0% |
| Exit | GlaxoSmithKline PLCcall | $0 | – | -291,300 | -100.0% | -0.00% | – | |
| NVAX | Exit | Novavax Inc | $0 | – | -1,543 | -100.0% | -0.00% | – |
| Exit | Energy Select Sector SPDR Fundput | $0 | – | -50,000 | -100.0% | -0.02% | – | |
| ICL | Exit | Israel Chemicals Ltd | $0 | – | -40,116 | -100.0% | -0.05% | – |
| MLNX | Exit | Mellanox Technologies Ltd | $0 | – | -12,517 | -100.0% | -0.09% | – |
| KBIO | Exit | KaloBios Pharmaceuticals Inc | $0 | – | -349,560 | -100.0% | -0.10% | – |
| Exit | Ardelyx Inc | $0 | – | -32,700 | -100.0% | -0.10% | – | |
| ACRX | Exit | AcelRx Pharmaceuticals Inc | $0 | – | -100,000 | -100.0% | -0.12% | – |
| ONTY | Exit | Oncothyreon Inc | $0 | – | -428,000 | -100.0% | -0.14% | – |
| ZSPH | Exit | ZS Pharma Inc | $0 | – | -20,682 | -100.0% | -0.15% | – |
| RPRX | Exit | Repros Therapeutics Inc | $0 | – | -100,000 | -100.0% | -0.17% | – |
| RXDX | Exit | Ignyta Inc | $0 | – | -179,055 | -100.0% | -0.21% | – |
| WIX | Exit | Wix.com Ltd | $0 | – | -59,108 | -100.0% | -0.21% | – |
| Exit | Amgen Inc | $0 | – | -8,550 | -100.0% | -0.23% | – | |
| Exit | Valeant Pharmaceuticals Interncall | $0 | – | -97,200 | -100.0% | -0.24% | – | |
| CKP | Exit | Check Point Software Technolog | $0 | – | -19,688 | -100.0% | -0.26% | – |
| CTIC | Exit | Cell Therapeutics Inc | $0 | – | -750,000 | -100.0% | -0.30% | – |
| LJPC | Exit | La Jolla Pharmaceutical Co | $0 | – | -100,230 | -100.0% | -0.32% | – |
| NICE | Exit | NICE Systems Ltdsponsored adr | $0 | – | -39,652 | -100.0% | -0.34% | – |
| ENTA | Exit | Enanta Pharmaceuticals Inc | $0 | – | -40,000 | -100.0% | -0.35% | – |
| VTL | Exit | Vital Therapies Inc | $0 | – | -81,900 | -100.0% | -0.35% | – |
| CSX | Exit | CSX Corp | $0 | – | -59,648 | -100.0% | -0.37% | – |
| ZFGN | Exit | Zafgen Inc | $0 | – | -72,100 | -100.0% | -0.38% | – |
| CEMP | Exit | Cempra Inc | $0 | – | -100,000 | -100.0% | -0.40% | – |
| BCOMF | Exit | B Communications Ltd | $0 | – | -134,174 | -100.0% | -0.41% | – |
| SRPT | Exit | Sarepta Therapeutics Inc | $0 | – | -175,000 | -100.0% | -0.43% | – |
| PRQR | Exit | ProQR Therapeutics BV | $0 | – | -130,000 | -100.0% | -0.48% | – |
| P103PS | Exit | NPS Pharmaceuticals Inc | $0 | – | -80,000 | -100.0% | -0.49% | – |
| ESRX | Exit | Express Scripts Holding Co | $0 | – | -33,966 | -100.0% | -0.49% | – |
| DRNA | Exit | Dicerna Pharmaceuticals Inc | $0 | – | -176,802 | -100.0% | -0.50% | – |
| Exit | Alder Biopharmaceuticals Inc | $0 | – | -100,000 | -100.0% | -0.50% | – | |
| CLDN | Exit | Celladon Corp | $0 | – | -150,656 | -100.0% | -0.50% | – |
| Exit | Arrowhead Research Corp | $0 | – | -400,000 | -100.0% | -0.50% | – | |
| ACOR | Exit | Acorda Therapeutics Inc | $0 | – | -79,105 | -100.0% | -0.55% | – |
| VRTX | Exit | Vertex Pharmaceuticals Inc | $0 | – | -30,000 | -100.0% | -0.61% | – |
| ITRN | Exit | Ituran Location and Control Lt | $0 | – | -168,203 | -100.0% | -0.63% | – |
| CYTK | Exit | Cytokinetics Inc | $0 | – | -493,212 | -100.0% | -0.67% | – |
| Exit | Gilead Sciences Inccall | $0 | – | -394,200 | -100.0% | -0.67% | – | |
| GSK | Exit | GlaxoSmithKline PLCsponsored adr | $0 | – | -98,200 | -100.0% | -0.72% | – |
| XLF | Exit | Financial Select Sector SPDR Fsbi int-finl | $0 | – | -210,000 | -100.0% | -0.88% | – |
| Exit | Amgen Inccall | $0 | – | -120,200 | -100.0% | -0.93% | – | |
| MYL | Exit | Mylan Inc/PA | $0 | – | -97,100 | -100.0% | -0.93% | – |
| Exit | Apple Inc | $0 | – | -52,803 | -100.0% | -0.99% | – | |
| PCYC | Exit | Pharmacyclics Inc | $0 | – | -48,840 | -100.0% | -1.02% | – |
| LLY | Exit | Eli Lilly & Co | $0 | – | -87,100 | -100.0% | -1.02% | – |
| Exit | AstraZeneca PLCsponsored adr | $0 | – | -86,637 | -100.0% | -1.04% | – | |
| GCVRZ | Exit | Sanofiright 12/31/2020 | $0 | – | -67,960 | -100.0% | -1.06% | – |
| Exit | Bellicum Pharmaceuticals | $0 | – | -331,514 | -100.0% | -1.18% | – | |
| Exit | Allergan Inc/United Statescall | $0 | – | -250,000 | -100.0% | -1.40% | – | |
| ESLT | Exit | Elbit Systems Ltdord | $0 | – | -144,759 | -100.0% | -1.51% | – |
| MNKKQ | Exit | Mallinckrodt PLC | $0 | – | -90,940 | -100.0% | -1.53% | – |
| Exit | Merck & Co Inc | $0 | – | -167,530 | -100.0% | -1.62% | – | |
| ISRL | Exit | Isramco Negev 2 LP | $0 | – | -64,958,387 | -100.0% | -1.90% | – |
| SLXP | Exit | SALIX PHARMACEUTICALS LT | $0 | – | -158,500 | -100.0% | -3.10% | – |
Other managers
Other managers that, in addition to the filing manager(s), that filed the EDGAR filing(s):
Original filings
The following EDGAR filing(s) were analyzed to create this report:
- View 13F-HR filed 2015-05-11
Top long-term holdings
| Name | Quarters owned | Latest quarter owned | Max weighting |
|---|---|---|---|
| TEVA PHARMACEUTICAL-SP ADR | 36 | Q3 2023 | 8.4% |
| MERCK & CO INC NEW | 35 | Q3 2023 | 8.4% |
| NICE Systems Ltd | 27 | Q3 2023 | 4.4% |
| BIOGEN INC | 26 | Q3 2023 | 6.7% |
| AMICUS THERAPEUTICS INC | 26 | Q2 2022 | 4.3% |
| PFIZER INC | 25 | Q3 2023 | 9.2% |
| SAREPTA THERAPEUTICS INC | 25 | Q3 2023 | 3.2% |
| JOHNSON & JOHNSON | 24 | Q3 2023 | 8.0% |
| UNIQURE NV | 23 | Q3 2023 | 1.2% |
| SYNDAX PHARMACEUTICALS INC | 22 | Q3 2023 | 3.9% |
View SPHERA FUNDS MANAGEMENT LTD.'s complete holdings history.
Latest significant ownerships (13-D/G)
| Filed | Shares | Percentage | |
|---|---|---|---|
| Cyclacel Pharmaceuticals, Inc. | February 06, 2023 | 250,000 | 2.0% |
| Altimmune, Inc. | February 14, 2022 | 1,244,241 | 3.1% |
| Allot Ltd. | February 16, 2021 | 1,129,054 | 3.2% |
| Larimar Therapeutics, Inc. | February 16, 2021 | ? | ? |
| Neos Therapeutics, Inc. | February 16, 2021 | ? | ? |
| Orgenesis Inc. | February 16, 2021 | 525,216 | 0.0% |
| Sio Gene Therapies Inc. | February 16, 2021 | ? | ? |
| X4 Pharmaceuticals, Inc | February 16, 2021 | 250,000 | 0.0% |
| Axovant Gene Therapies Ltd. | February 25, 2020 | 2,931,017 | 8.0% |
| Axovant Gene Therapies Ltd. | February 11, 2020 | 398,540 | 1.8% |
View SPHERA FUNDS MANAGEMENT LTD.'s complete significant-ownership history.
Latest filings
| Type | Filed |
|---|---|
| 13F-HR | 2024-05-15 |
| 13F-HR/A | 2024-02-15 |
| 13F-HR | 2024-02-14 |
| SC 13G | 2024-02-08 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| 13F-HR | 2023-11-14 |
| SC 13G | 2023-10-10 |
View SPHERA FUNDS MANAGEMENT LTD.'s complete filings history.
All filings
- Holdings (13F-HR)
- Significant ownership (13-D/G)
- Insider transactions (4, 5, 6)
- Events (8-K)
- Shareholder votes (proxy)
View complete filings history.