$270 Million is the total value of Sio Capital Management, LLC's 47 reported holdings in Q4 2022. The portfolio turnover from Q3 2022 to Q4 2022 was 67.3% .
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| RXDX | Buy | PROMETHEUS BIOSCIENCES INCput | $63,162,000 | +222.2% | 574,200 | +72.8% | 23.36% | +275.0% |
| MSAC | MEDICUS SCIENCES ACQUISITION | $23,392,610 | +1.7% | 2,323,000 | 0.0% | 8.65% | +18.4% | |
| BCYC | BICYCLE THERAPEUTICS PLCsponsored ads | $20,229,380 | +27.3% | 683,425 | 0.0% | 7.48% | +48.1% | |
| CI | CIGNA CORP | $17,432,129 | +19.4% | 52,611 | 0.0% | 6.45% | +39.0% | |
| OGN | Sell | ORGANON & CO | $16,418,259 | +11.6% | 587,836 | -6.5% | 6.07% | +29.9% |
| UTHR | Buy | UNITED THERAPEUTICS CORP | $15,283,548 | +62.3% | 54,959 | +22.2% | 5.65% | +89.0% |
| DGX | New | QUEST DIAGNOSTICS INCput | $14,392,480 | – | 92,000 | +100.0% | 5.32% | – |
| ABC | Sell | AMERISOURCEBERGEN CORP | $13,985,758 | -63.4% | 84,399 | -70.1% | 5.17% | -57.4% |
| MDT | New | MEDTRONIC PLC | $9,948,160 | – | 128,000 | +100.0% | 3.68% | – |
| STAA | New | STAAR SURGICAL CO | $7,627,042 | – | 157,129 | +100.0% | 2.82% | – |
| ICLR | New | ICON PLC | $6,601,198 | – | 33,983 | +100.0% | 2.44% | – |
| INGN | Sell | INOGEN INC | $5,650,699 | -55.4% | 286,692 | -45.0% | 2.09% | -48.0% |
| AVTR | New | AVANTOR INC | $5,272,500 | – | 250,000 | +100.0% | 1.95% | – |
| HSKA | New | HESKA CORP | $5,240,647 | – | 84,309 | +100.0% | 1.94% | – |
| PTGX | New | PROTAGONIST THERAPEUTICS INC | $4,741,868 | – | 434,635 | +100.0% | 1.75% | – |
| NVAX | New | NOVAVAX INC | $3,495,200 | – | 340,000 | +100.0% | 1.29% | – |
| CBAY | CYMABAY THERAPEUTICS INC | $3,483,675 | +79.1% | 555,610 | 0.0% | 1.29% | +108.4% | |
| PHVS | New | PHARVARIS NV | $3,206,250 | – | 285,000 | +100.0% | 1.19% | – |
| MACK | New | MERRIMACK PHARMACEUTICALS INC | $2,865,000 | – | 250,000 | +100.0% | 1.06% | – |
| RETA | New | REATA PHARMACEUTICALS INCput | $2,545,330 | – | 67,000 | +100.0% | 0.94% | – |
| HSAQ | HEALTH SCIENCES ACQUISITIONS CORP 2 | $2,495,000 | +0.8% | 250,000 | 0.0% | 0.92% | +17.4% | |
| EUCRU | EUCRATES BIOMEDICAL ACQUISITION CORP.unit 10/23/2027 | $2,481,767 | -0.4% | 248,674 | 0.0% | 0.92% | +15.9% | |
| CTIC | New | CTI BIOPHARMA CORP | $1,983,300 | – | 330,000 | +100.0% | 0.73% | – |
| ISEE | IVERIC BIO INCput | $1,849,824 | +19.3% | 86,400 | 0.0% | 0.68% | +38.7% | |
| XFOR | Buy | X4 PHARMACEUTICALS INC | $1,813,181 | -25.3% | 1,825,963 | +28.7% | 0.67% | -13.0% |
| Buy | MODULAR MEDICAL INC | $1,378,704 | -41.7% | 689,352 | +20.0% | 0.51% | -32.2% | |
| MRUS | MERUS NV | $1,360,633 | -22.8% | 87,953 | 0.0% | 0.50% | -10.2% | |
| AGLE | Sell | AEGLEA BIO THERAPEUTICS INC | $1,351,931 | -45.0% | 3,004,959 | -35.6% | 0.50% | -35.9% |
| SVRA | Buy | SAVARA INC | $1,342,994 | +1.2% | 866,448 | +1.2% | 0.50% | +17.8% |
| IDYA | IDEAYA BIOSCIENCES INC | $1,271,900 | +21.8% | 70,000 | 0.0% | 0.47% | +41.6% | |
| TYRA BIOSCIENCES INC | $1,156,408 | -13.5% | 152,159 | 0.0% | 0.43% | +0.7% | ||
| MBRX | MOLECULIN BIOTECH INC | $1,099,064 | +0.0% | 1,036,853 | 0.0% | 0.41% | +16.3% | |
| VNDA | Sell | VANDA PHARMACEUTICALS INC | $1,007,442 | -79.1% | 136,325 | -72.1% | 0.37% | -75.7% |
| RLMD | New | RELMADA THERAPEUTICS INC | $821,895 | – | 235,500 | +100.0% | 0.30% | – |
| RLMD | Sell | RELMADA THERAPEUTICS INCput | $822,244 | -96.3% | 235,600 | -61.1% | 0.30% | -95.7% |
| FUSN | FUSION PHARMACEUTICALS INC | $820,411 | +4.6% | 260,448 | 0.0% | 0.30% | +21.7% | |
| CNTB | CONNECT BIOPHARMA HOLDINGS LTDads | $518,665 | -32.7% | 597,678 | 0.0% | 0.19% | -21.6% | |
| SIEN | New | SIENTRA INC | $517,395 | – | 2,550,000 | +100.0% | 0.19% | – |
| ASLN | ASLAN PHARMACEUTICALS LTDads | $457,473 | -39.9% | 1,270,758 | 0.0% | 0.17% | -30.2% | |
| ELEV | ELEVATION ONCOLOGY INC | $341,744 | -15.8% | 359,731 | 0.0% | 0.13% | -2.3% | |
| NXTC | NEXTCURE INC | $183,300 | -48.8% | 130,000 | 0.0% | 0.07% | -40.4% | |
| CMAX | Buy | CAREMAX INC*w exp 06/08/202 | $118,897 | -45.5% | 43,549 | +41.7% | 0.04% | -36.2% |
| VINC | VINCERX PHARMA INC | $104,090 | -26.2% | 102,049 | 0.0% | 0.04% | -15.6% | |
| NYXOAH SA | $80,389 | -20.4% | 16,110 | 0.0% | 0.03% | -6.2% | ||
| New | HUMACYTE INC*w exp 08/27/202 | $20,314 | – | 49,998 | +100.0% | 0.01% | – | |
| NLTX | NEOLEUKIN THERAPEUTICS INC | $19,501 | -22.0% | 38,312 | 0.0% | 0.01% | -12.5% | |
| CMAXW | Exit | CAREMAX INC*w exp 06/08/202 | $0 | – | -12,808 | -100.0% | -0.01% | – |
| Exit | RENOVACOR INC*w exp 99/99/999 | $0 | – | -400,000 | -100.0% | -0.01% | – | |
| Exit | HUMACYTE INC*w exp 09/21/202 | $0 | – | -49,998 | -100.0% | -0.02% | – | |
| CLNN | Exit | CLENE INC.put | $0 | – | -22,700 | -100.0% | -0.02% | – |
| NBSE | Exit | NEUBASE THERAPEUTICS INC | $0 | – | -259,441 | -100.0% | -0.03% | – |
| ANIP | Exit | ANI PHARMACEUTICALS INC | $0 | – | -40,000 | -100.0% | -0.41% | – |
| AFMD | Exit | AFFIMED NV | $0 | – | -821,065 | -100.0% | -0.54% | – |
| Exit | RENOVACOR INC | $0 | – | -735,908 | -100.0% | -0.59% | – | |
| BHC | Exit | BAUSCH HEALTH COMPANIES INCput | $0 | – | -281,200 | -100.0% | -0.62% | – |
| UHS | Exit | UNIVERSAL HEALTH SERVICES INCcl b | $0 | – | -40,725 | -100.0% | -1.14% | – |
| NARI | Exit | INARI MEDICAL INC | $0 | – | -57,466 | -100.0% | -1.33% | – |
| PNT | Exit | POINT BIOPHARMA GLOBAL INC | $0 | – | -544,545 | -100.0% | -1.34% | – |
| SNN | Exit | SMITH & NEPHEW PLCspdn adr new | $0 | – | -228,390 | -100.0% | -1.68% | – |
| SKIN | Exit | THE BEAUTY HEALTH CO | $0 | – | -658,964 | -100.0% | -2.47% | – |
| CNC | Exit | CENTENE CORP DEL | $0 | – | -127,011 | -100.0% | -3.14% | – |
| SNY | Exit | SANOFI SAsponsored adr | $0 | – | -356,888 | -100.0% | -4.31% | – |
| Exit | GSK PLCsponsored ads | $0 | – | -790,600 | -100.0% | -7.39% | – | |
| APLS | Exit | APELLIS PHARMACEUTICALS INCput | $0 | – | -507,700 | -100.0% | -11.02% | – |
Original filings
The following EDGAR filing(s) were analyzed to create this report:
- View 13F-HR filed 2023-02-13
Top long-term holdings
| Name | Quarters owned | Latest quarter owned | Max weighting |
|---|---|---|---|
| VIKING THERAPEUTICS INC | 24 | Q3 2023 | 3.4% |
| UNITED THERAPEUTICS ORD | 23 | Q3 2023 | 8.3% |
| CARDINAL HEALTH ORD | 20 | Q2 2022 | 7.2% |
| SANOFI SA | 19 | Q3 2022 | 9.8% |
| MEDTRONIC PLC | 18 | Q3 2023 | 5.2% |
| CATALYST BIOSCIENCES INC | 18 | Q3 2021 | 17.8% |
| PFENEX ORD | 18 | Q4 2019 | 5.9% |
| AEGLEA BIOTHERAPEUTICS INC | 18 | Q1 2023 | 1.1% |
| HCA HEALTHCARE INC | 17 | Q2 2022 | 5.5% |
| MCKESSON ORD | 17 | Q1 2022 | 6.0% |
View Sio Capital Management, LLC's complete holdings history.
Latest significant ownerships (13-D/G)
| Filed | Shares | Percentage | |
|---|---|---|---|
| Modular Medical, Inc. | February 13, 2023 | 1,091,479 | 10.0% |
| Cellectar Biosciences, Inc. | February 10, 2022 | ? | ? |
| CURIS INC | February 10, 2022 | 3,866,645 | 4.2% |
| Salarius Pharmaceuticals, Inc. | February 10, 2022 | 1,354,291 | 3.0% |
| Larimar Therapeutics, Inc. | February 16, 2021 | 188,661 | 1.2% |
| ACHIEVE LIFE SCIENCES, INC. | February 14, 2020 | ? | ? |
| Bionano Genomics, Inc | February 14, 2020 | 1,210,821 | 4.6% |
| Brickell Biotech, Inc. | February 14, 2020 | ? | ? |
| Trillium Therapeutics Inc. | February 14, 2020 | 2,751,186 | 9.8% |
| ZAFGEN, INC. | February 14, 2020 | 2,283,164 | 6.1% |
View Sio Capital Management, LLC's complete significant-ownership history.
Latest filings
| Type | Filed |
|---|---|
| SC 13G/A | 2024-02-14 |
| SC 13G | 2024-02-14 |
| SC 13G | 2024-02-14 |
| 13F-HR | 2024-02-13 |
| 13F-HR | 2023-11-14 |
| 13F-HR | 2023-08-14 |
| 13F-HR | 2023-05-12 |
| 13F-HR | 2023-02-13 |
| SC 13G | 2023-02-13 |
| 13F-HR | 2022-11-14 |
View Sio Capital Management, LLC's complete filings history.
All filings
- Holdings (13F-HR)
- Significant ownership (13-D/G)
- Insider transactions (4, 5, 6)
- Events (8-K)
- Shareholder votes (proxy)
View complete filings history.