Q4 2016
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| BCRX | Buy | BioCryst Pharmaceuticals Inc | $7,312,000 | +64.9% | 1,155,104 | +14.9% | 7.86% | +80.4% |
| RARX | New | Ra Pharmaceuticals | $3,532,000 | – | 232,500 | – | 3.80% | – |
| OCRX | Buy | Ocera Therapeutics | $1,915,000 | -15.3% | 912,050 | +6.5% | 2.06% | -7.4% |
| RGNX | Exit | REGENXBIO Inc | $0 | – | -24,089 | – | -0.33% | – |
| ACHN | Exit | Achillion Pharmaceuticals Inc | $0 | – | -180,000 | – | -1.43% | – |
| BGNE | Exit | BeiGene Ltd | $0 | – | -51,000 | – | -1.54% | – |
| ZFGN | Exit | Zafgen Inc | $0 | – | -602,114 | – | -1.96% | – |
Q3 2016
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| CHRS | Sell | Coherus Biosciences Inc | $8,181,000 | -20.7% | 305,505 | -50.0% | 8.04% | -24.8% |
| CLCD | New | CoLucid Pharmaceuticals | $2,601,000 | – | 68,190 | – | 2.56% | – |
| OCRX | Buy | Ocera Therapeutics | $2,261,000 | +49.4% | 856,550 | +7.5% | 2.22% | +41.8% |
| ADHD | Buy | Alcobra Ltd | $1,628,000 | -41.8% | 658,910 | +5.7% | 1.60% | -44.8% |
| ACHN | New | Achillion Pharmaceuticals Inc | $1,458,000 | – | 180,000 | – | 1.43% | – |
| RGNX | Sell | REGENXBIO Inc | $337,000 | -19.8% | 24,089 | -54.1% | 0.33% | -23.9% |
| BOLD | New | Audentes Therapeutics | $267,000 | – | 15,000 | – | 0.26% | – |
| GBT | Exit | Global Blood Therapeutics | $0 | – | -72,990 | – | -1.26% | – |
| Exit | Cynapsus Therapeutics Inc | $0 | – | -108,575 | – | -1.87% | – |
Q2 2016
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| New | DBV Technologies | $29,114,000 | – | 456,893 | – | 30.17% | – | |
| HRTX | New | Heron Therapeutics Inc | $19,778,000 | – | 1,095,734 | – | 20.50% | – |
| CHRS | New | Coherus Biosciences Inc | $10,320,000 | – | 611,010 | – | 10.70% | – |
| FLML | New | Flamel Technologies S.A. | $5,370,000 | – | 500,000 | – | 5.56% | – |
| ZFGN | New | Zafgen Inc | $3,607,000 | – | 602,114 | – | 3.74% | – |
| ADVM | New | Adverum Biotechnologies | $3,485,000 | – | 1,102,735 | – | 3.61% | – |
| BCRX | New | BioCryst Pharmaceuticals Inc | $2,854,000 | – | 1,005,104 | – | 2.96% | – |
| ADHD | New | Alcobra Ltd | $2,799,000 | – | 623,313 | – | 2.90% | – |
| LPCN | New | Lipocine Inc | $2,584,000 | – | 849,921 | – | 2.68% | – |
| AXGT | New | Axovant Sciences Ltd | $2,364,000 | – | 184,110 | – | 2.45% | – |
| AKTX | New | Akari Therapeutics Plc | $2,136,000 | – | 158,352 | – | 2.21% | – |
| New | Cynapsus Therapeutics Inc | $1,806,000 | – | 108,575 | – | 1.87% | – | |
| BGNE | New | BeiGene Ltd | $1,520,000 | – | 51,000 | – | 1.58% | – |
| OCRX | New | Ocera Therapeutics | $1,513,000 | – | 796,550 | – | 1.57% | – |
| EDGE | New | Edge Therapeutics Inc | $1,365,000 | – | 135,000 | – | 1.42% | – |
| ABIO | New | ARCA biopharma Inc | $1,341,000 | – | 462,399 | – | 1.39% | – |
| GBT | New | Global Blood Therapeutics | $1,211,000 | – | 72,990 | – | 1.26% | – |
| ASND | New | Ascendis Pharma A/S | $1,194,000 | – | 90,000 | – | 1.24% | – |
| STML | New | Stemline Therapeutics Inc | $917,000 | – | 135,420 | – | 0.95% | – |
| CTMX | New | CytomX Therapeutics Inc | $656,000 | – | 64,200 | – | 0.68% | – |
| RGNX | New | REGENXBIO Inc | $420,000 | – | 52,500 | – | 0.44% | – |
| DNAI | New | ProNAI Therapeutics Inc | $112,000 | – | 56,056 | – | 0.12% | – |
| AGLE | New | Aeglea BioTherapeutics | $29,000 | – | 6,000 | – | 0.03% | – |
Q4 2015
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| OCRX | Exit | Ocera Therapeutics | $0 | – | -703,730 | – | -0.57% | – |
| STML | Exit | Stemline Therapeutics Inc | $0 | – | -451,400 | – | -1.02% | – |
| DNAI | Exit | ProNAI Therapeutics Inc | $0 | – | -250,000 | – | -1.32% | – |
| Exit | Cynapsus Therapeutics Inc | $0 | – | -367,427 | – | -1.52% | – | |
| ABIO | Exit | ARCA biopharma Inc | $0 | – | -1,541,331 | – | -1.96% | – |
| FLML | Exit | Flamel Technologies S.A. | $0 | – | -500,000 | – | -2.09% | – |
| ADHD | Exit | Alcobra Ltd | $0 | – | -1,500,000 | – | -2.32% | – |
| AAVL | Exit | Avalanche Biotechnologies Inc | $0 | – | -1,382,735 | – | -2.92% | – |
| AKTX | Exit | Akari Therapeutics Plc | $0 | – | -527,842 | – | -3.25% | – |
| ASND | Exit | Ascendis Pharma A/S | $0 | – | -811,152 | – | -3.68% | – |
| LPCN | Exit | Lipocine Inc | $0 | – | -1,269,921 | – | -3.85% | – |
| ZFGN | Exit | Zafgen Inc | $0 | – | -541,480 | – | -4.44% | – |
| CHRS | Exit | Coherus Biosciences Inc | $0 | – | -870,269 | – | -4.47% | – |
| RGNX | Exit | REGENXBIO Inc | $0 | – | -1,083,454 | – | -5.17% | – |
| HRTX | Exit | Heron Therapeutics Inc | $0 | – | -1,095,734 | – | -6.85% | – |
| GWPH | Exit | GW Pharmaceuticals | $0 | – | -311,853 | – | -7.30% | – |
| Exit | DBV Technologies | $0 | – | -693,810 | – | -11.69% | – | |
| ANAC | Exit | Anacor Pharmaceuticals Inc | $0 | – | -1,178,474 | – | -35.56% | – |
Q3 2015
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| RGNX | New | REGENXBIO Inc | $20,178,000 | – | 1,083,454 | – | 5.17% | – |
| AKTX | New | Akari Therapeutics Plc | $12,666,000 | – | 527,842 | – | 3.25% | – |
| ABIO | Sell | ARCA biopharma Inc | $7,645,000 | -38.4% | 1,541,331 | -85.7% | 1.96% | -44.0% |
| DNAI | New | ProNAI Therapeutics Inc | $5,130,000 | – | 250,000 | – | 1.32% | – |
| JUNO | Exit | Juno Therapeutics Inc | $0 | – | -90,206 | – | -1.36% | – |
| ZSPH | Exit | ZS Pharma Inc | $0 | – | -100,000 | – | -1.48% | – |
| BCRX | Exit | BioCryst Pharmaceuticals Inc | $0 | – | -373,686 | – | -1.57% | – |
Q2 2015
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| ANAC | New | Anacor Pharmaceuticals Inc | $91,249,000 | – | 1,178,474 | – | 25.74% | – |
| GWPH | New | GW Pharmaceuticals | $38,308,000 | – | 311,853 | – | 10.81% | – |
| New | DBV Technologies | $37,149,000 | – | 693,810 | – | 10.48% | – | |
| HRTX | New | Heron Therapeutics Inc | $34,143,000 | – | 1,095,734 | – | 9.63% | – |
| CHRS | New | Coherus Biosciences Inc | $25,151,000 | – | 870,269 | – | 7.10% | – |
| AAVL | New | Avalanche Biotechnologies Inc | $22,455,000 | – | 1,382,735 | – | 6.33% | – |
| ZFGN | New | Zafgen Inc | $18,751,000 | – | 541,480 | – | 5.29% | – |
| ASND | New | Ascendis Pharma A/S | $14,070,000 | – | 811,152 | – | 3.97% | – |
| ABIO | New | ARCA biopharma Inc | $12,407,000 | – | 10,789,324 | – | 3.50% | – |
| LPCN | New | Lipocine Inc | $10,896,000 | – | 1,269,921 | – | 3.07% | – |
| FLML | New | Flamel Technologies S.A. | $10,595,000 | – | 500,000 | – | 2.99% | – |
| ADHD | New | Alcobra Ltd | $9,810,000 | – | 1,500,000 | – | 2.77% | – |
| New | Cynapsus Therapeutics Inc | $5,892,000 | – | 367,427 | – | 1.66% | – | |
| BCRX | New | BioCryst Pharmaceuticals Inc | $5,579,000 | – | 373,686 | – | 1.57% | – |
| STML | New | Stemline Therapeutics Inc | $5,313,000 | – | 451,400 | – | 1.50% | – |
| ZSPH | New | ZS Pharma Inc | $5,239,000 | – | 100,000 | – | 1.48% | – |
| JUNO | New | Juno Therapeutics Inc | $4,811,000 | – | 90,206 | – | 1.36% | – |
| OCRX | New | Ocera Therapeutics | $2,674,000 | – | 703,730 | – | 0.75% | – |
Q4 2014
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| ALXA | Exit | Alexza Pharmaceuticals Inc | $0 | – | -71,212 | – | -0.08% | – |
| STML | Exit | Stemline Therapeutics Inc | $0 | – | -71,000 | – | -0.40% | – |
| OCRX | Exit | Ocera Therapeutics | $0 | – | -703,730 | – | -1.55% | – |
| OHRP | Exit | OHR Pharmaceutical | $0 | – | -477,000 | – | -1.55% | – |
| ZSPH | Exit | ZS Pharma Inc | $0 | – | -100,000 | – | -1.76% | – |
| TXMD | Exit | TherapeuticsMD Inc | $0 | – | -846,500 | – | -1.76% | – |
| LPCN | Exit | Lipocine Inc | $0 | – | -669,921 | – | -1.84% | – |
| NBIX | Exit | Neurocrine Biosciences Inc | $0 | – | -303,503 | – | -2.14% | – |
| FLML | Exit | Flamel Technologies S.A. | $0 | – | -500,000 | – | -3.22% | – |
| HRTX | Exit | Heron Therapeutics Inc | $0 | – | -1,095,734 | – | -4.10% | – |
| ZFGN | Exit | Zafgen Inc | $0 | – | -541,480 | – | -4.50% | – |
| Exit | Radius Health Inc | $0 | – | -525,000 | – | -4.96% | – | |
| BCRX | Exit | BioCryst Pharmaceuticals Inc | $0 | – | -1,744,356 | – | -7.67% | – |
| DYAX | Exit | Dyax Corp | $0 | – | -2,000,859 | – | -9.10% | – |
| GWPH | Exit | GW Pharmaceuticals | $0 | – | -311,853 | – | -11.33% | – |
| Exit | DBV Technologies | $0 | – | -565,000 | – | -11.84% | – | |
| ANAC | Exit | Anacor Pharmaceuticals Inc | $0 | – | -1,178,474 | – | -12.96% | – |
| AAVL | Exit | Avalanche Biotechnologies Inc | $0 | – | -1,382,735 | – | -19.25% | – |
Q3 2014
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| AAVL | New | Avalanche Biotechnologies Inc | $42,833,000 | – | 1,382,735 | – | 19.25% | – |
| ANAC | Sell | Anacor Pharmaceuticals Inc | $28,837,000 | +5.2% | 1,178,474 | -23.8% | 12.96% | -11.5% |
| Buy | DBV Technologies | $26,334,000 | +111.5% | 565,000 | +17.7% | 11.84% | +77.8% | |
| LPCN | Buy | Lipocine Inc | $4,093,000 | +372.1% | 669,921 | +371.4% | 1.84% | +297.2% |
| STML | New | Stemline Therapeutics Inc | $884,000 | – | 71,000 | – | 0.40% | – |
| ALXA | Sell | Alexza Pharmaceuticals Inc | $166,000 | -85.3% | 71,212 | -71.3% | 0.08% | -87.6% |
| KERX | Exit | Keryx Biopharmaceuticals Inc | $0 | – | -700,273 | – | -5.76% | – |
Q2 2014
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| GWPH | New | GW Pharmaceuticals | $33,459,000 | – | 311,853 | – | 17.88% | – |
| ANAC | New | Anacor Pharmaceuticals Inc | $27,411,000 | – | 1,545,999 | – | 14.65% | – |
| BCRX | New | BioCryst Pharmaceuticals Inc | $22,241,000 | – | 1,744,356 | – | 11.89% | – |
| DYAX | New | Dyax Corp | $19,208,000 | – | 2,000,859 | – | 10.27% | – |
| HRTX | New | Heron Therapeutics Inc | $13,499,000 | – | 1,095,734 | – | 7.22% | – |
| New | DBV Technologies | $12,451,000 | – | 480,000 | – | 6.66% | – | |
| KERX | New | Keryx Biopharmaceuticals Inc | $10,770,000 | – | 700,273 | – | 5.76% | – |
| ZFGN | New | Zafgen Inc | $10,710,000 | – | 541,480 | – | 5.72% | – |
| FLML | New | Flamel Technologies S.A. | $7,500,000 | – | 500,000 | – | 4.01% | – |
| New | Radius Health Inc | $6,825,000 | – | 525,000 | – | 3.65% | – | |
| OCRX | New | Ocera Therapeutics | $5,376,000 | – | 703,730 | – | 2.87% | – |
| OHRP | New | OHR Pharmaceutical | $4,536,000 | – | 477,000 | – | 2.42% | – |
| NBIX | New | Neurocrine Biosciences Inc | $4,502,000 | – | 303,503 | – | 2.41% | – |
| TXMD | New | TherapeuticsMD Inc | $3,742,000 | – | 846,500 | – | 2.00% | – |
| ZSPH | New | ZS Pharma Inc | $2,875,000 | – | 100,000 | – | 1.54% | – |
| ALXA | New | Alexza Pharmaceuticals Inc | $1,133,000 | – | 247,812 | – | 0.61% | – |
| LPCN | New | Lipocine Inc | $867,000 | – | 142,100 | – | 0.46% | – |
Q4 2013
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| GTXI | Exit | GTx Inc | $0 | – | -500,000 | – | -0.56% | – |
| OPHT | Exit | Ophthotech Corporation | $0 | – | -52,500 | – | -0.86% | – |
| ALXA | Exit | Alexza Pharmaceuticals Inc | $0 | – | -399,999 | – | -1.13% | – |
| APPA | Exit | A P Pharma Inc | $0 | – | -9,067,700 | – | -1.68% | – |
| THLD | Exit | Threshold Pharmaceuticals Inc | $0 | – | -684,000 | – | -1.76% | – |
| BIOD | Exit | Biodel Inc | $0 | – | -1,281,592 | – | -2.23% | – |
| Exit | DBV Technologies | $0 | – | -480,000 | – | -2.81% | – | |
| VNDA | Exit | Vanda Pharmaceuticals Inc | $0 | – | -491,075 | – | -2.97% | – |
| HPTX | Exit | Hyperion Therapeutics Inc | $0 | – | -217,571 | – | -3.14% | – |
| CHTP | Exit | Chelsea Therapeutics International Ltd | $0 | – | -2,516,870 | – | -4.16% | – |
| TSRO | Exit | TESARO Inc | $0 | – | -261,130 | – | -5.59% | – |
| NBIX | Exit | Neurocrine Biosciences Inc | $0 | – | -1,271,303 | – | -7.95% | – |
| GWPH | Exit | GW Pharmaceuticals | $0 | – | -837,800 | – | -8.02% | – |
| BCRX | Exit | BioCryst Pharmaceuticals Inc | $0 | – | -2,180,656 | – | -8.77% | – |
| ANAC | Exit | Anacor Pharmaceuticals Inc | $0 | – | -1,610,856 | – | -9.45% | – |
| KERX | Exit | Keryx Biopharmaceuticals Inc | $0 | – | -2,048,773 | – | -11.42% | – |
| IRWD | Exit | Ironwood Pharmaceuticals Inc | $0 | – | -1,800,000 | – | -11.77% | – |
| DYAX | Exit | Dyax Corp | $0 | – | -4,156,508 | – | -15.75% | – |
Q3 2013
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| BCRX | Buy | BioCryst Pharmaceuticals Inc | $15,875,000 | +910.5% | 2,180,656 | +115.2% | 8.77% | +651.2% |
| NBIX | Sell | Neurocrine Biosciences Inc | $14,391,000 | -45.3% | 1,271,303 | -35.3% | 7.95% | -59.3% |
| HPTX | Sell | Hyperion Therapeutics Inc | $5,685,000 | +1.3% | 217,571 | -14.7% | 3.14% | -24.6% |
| VNDA | Sell | Vanda Pharmaceuticals Inc | $5,377,000 | -15.5% | 491,075 | -37.6% | 2.97% | -37.1% |
| New | DBV Technologies | $5,094,000 | – | 480,000 | – | 2.81% | – | |
| BIOD | Sell | Biodel Inc | $4,037,000 | -33.2% | 1,281,592 | -11.4% | 2.23% | -50.4% |
| APPA | New | A P Pharma Inc | $3,038,000 | – | 9,067,700 | – | 1.68% | – |
| OPHT | New | Ophthotech Corporation | $1,560,000 | – | 52,500 | – | 0.86% | – |
| ANTH | Exit | Anthera Pharmaceuticals Inc | $0 | – | -1,437,623 | – | -0.50% | – |
| STML | Exit | Stemline Therapeutics Inc | $0 | – | -50,000 | – | -0.88% | – |
Q2 2013
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| NBIX | New | Neurocrine Biosciences Inc | $26,287,000 | – | 1,964,673 | – | 19.52% | – |
| IRWD | New | Ironwood Pharmaceuticals Inc | $17,874,000 | – | 1,800,000 | – | 13.27% | – |
| KERX | New | Keryx Biopharmaceuticals Inc | $15,304,000 | – | 2,048,773 | – | 11.37% | – |
| DYAX | New | Dyax Corp | $14,382,000 | – | 4,156,508 | – | 10.68% | – |
| ANAC | New | Anacor Pharmaceuticals Inc | $9,005,000 | – | 1,610,856 | – | 6.69% | – |
| TSRO | New | TESARO Inc | $8,549,000 | – | 261,130 | – | 6.35% | – |
| GWPH | New | GW Pharmaceuticals | $7,381,000 | – | 837,800 | – | 5.48% | – |
| VNDA | New | Vanda Pharmaceuticals Inc | $6,363,000 | – | 787,459 | – | 4.72% | – |
| BIOD | New | Biodel Inc | $6,046,000 | – | 1,446,413 | – | 4.49% | – |
| CHTP | New | Chelsea Therapeutics International Ltd | $5,789,000 | – | 2,516,870 | – | 4.30% | – |
| HPTX | New | Hyperion Therapeutics Inc | $5,610,000 | – | 255,000 | – | 4.17% | – |
| THLD | New | Threshold Pharmaceuticals Inc | $3,598,000 | – | 684,000 | – | 2.67% | – |
| GTXI | New | GTx Inc | $3,300,000 | – | 500,000 | – | 2.45% | – |
| ALXA | New | Alexza Pharmaceuticals Inc | $1,736,000 | – | 399,999 | – | 1.29% | – |
| BCRX | New | BioCryst Pharmaceuticals Inc | $1,571,000 | – | 1,013,442 | – | 1.17% | – |
| STML | New | Stemline Therapeutics Inc | $1,192,000 | – | 50,000 | – | 0.88% | – |
| ANTH | New | Anthera Pharmaceuticals Inc | $666,000 | – | 1,437,623 | – | 0.50% | – |