DAFNA Capital Management LLC Activity Q4 2006-Q3 2023

Q3 2023

			Value		Shares		↓ Weighting
CYTK	Buy	CYTOKINETICS INC	$14,127,189	+30.2%	479,538	+44.1%	4.39%	+48.0%
IDYA	Buy	IDEAYA BIOSCIENCES INC	$13,485,144	+19.6%	499,820	+4.2%	4.20%	+36.1%
RVMD	Sell	REVOLUTION MEDICINES INC	$13,103,546	-4.4%	473,394	-7.6%	4.08%	+8.8%
ASND	Buy	ASCENDIS PHARMA A/Ssponsored adr	$12,754,892	+5.7%	136,212	+0.7%	3.97%	+20.2%
BPMC	Sell	BLUEPRINT MEDICINES CORP	$12,530,945	-21.2%	249,521	-0.8%	3.90%	-10.3%
MRUS	Buy	MERUS N V	$11,433,235	+12.8%	484,870	+26.0%	3.56%	+28.3%
KRTX	Buy	KARUNA THERAPEUTICS INC	$8,940,296	-2.2%	52,873	+25.4%	2.78%	+11.2%
NBIX	Sell	NEUROCRINE BIOSCIENCES INC	$8,281,688	+17.7%	73,615	-1.3%	2.58%	+33.9%
DAWN	Buy	DAY ONE BIOPHARMACEUTICALS I	$7,195,901	+18.8%	586,463	+15.7%	2.24%	+35.1%
SNDX	Buy	SYNDAX PHARMACEUTICALS INC	$6,655,576	-29.5%	458,373	+1.7%	2.07%	-19.8%
KALV	Sell	KALVISTA PHARMACEUTICALS INC	$5,831,273	+6.0%	605,532	-0.9%	1.81%	+20.6%
	Buy	2SEVENTY BIO INC	$5,674,063	+12.9%	1,447,465	+191.6%	1.76%	+28.5%
MORF	Buy	MORPHIC HOLDING INC	$5,309,347	-55.2%	231,748	+12.1%	1.65%	-49.1%
KURA	Buy	KURA ONCOLOGY INC	$5,023,150	+32.7%	550,784	+53.9%	1.56%	+50.9%
AXGN	Buy	AXOGEN INC	$4,679,470	+54.3%	935,894	+181.8%	1.46%	+75.6%
BCRX	Buy	BIOCRYST PHARMACEUTICALS INC	$4,616,160	+15.2%	652,000	+14.6%	1.44%	+31.1%
TNDM	Buy	TANDEM DIABETES CARE INC	$4,584,105	+69.8%	220,708	+100.6%	1.43%	+93.2%
ALEC	Sell	ALECTOR INC	$4,075,518	+6.1%	628,938	-1.6%	1.27%	+20.8%
MRTX	Sell	MIRATI THERAPEUTICS INC	$4,046,158	+18.3%	92,887	-1.9%	1.26%	+34.5%
RCUS	Sell	ARCUS BIOSCIENCES INC	$3,997,770	-12.8%	222,717	-1.3%	1.24%	-0.7%
VKTX	Buy	VIKING THERAPEUTICS INC	$3,538,581	-25.7%	319,655	+8.9%	1.10%	-15.4%
	New	AMYLYX PHARMACEUTICALS INC	$2,243,836	–	122,547	–	0.70%	–
	Buy	PROCEPT BIOROBOTICS CORP	$2,208,113	+680.8%	67,300	+741.2%	0.69%	+792.2%
	Buy	ASTRIA THERAPEUTICS INC	$2,204,378	+107.3%	295,493	+131.5%	0.69%	+135.7%
AUTL	Sell	AUTOLUS THERAPEUTICS PLCspon ads	$2,162,829	-2.3%	928,253	-0.2%	0.67%	+11.2%
KROS	Buy	KEROS THERAPEUTICS INC	$2,102,837	+9.8%	65,961	+38.4%	0.65%	+24.8%
GLPG	Buy	GALAPAGOS NVspon adr	$2,079,046	-2.9%	60,175	+14.2%	0.65%	+10.4%
	New	THIRD HARMONIC BIO INC	$1,917,000	–	300,000	–	0.60%	–
BWAY	Sell	BRAINSWAY LTDsponsored ads	$1,746,011	+51.7%	432,181	-14.4%	0.54%	+72.4%
CMPS	New	COMPASS PATHWAYS PLCsponsored ads	$1,428,200	–	193,000	–	0.44%	–
CERE	New	CEREVEL THERAPEUTICS HOLDINGS INC	$1,357,826	–	62,200	–	0.42%	–
IMGN	New	IMMUNOGEN INC	$1,317,210	–	83,000	–	0.41%	–
LRMR	Sell	LARIMAR THERAPEUTICS INC	$1,293,123	+17.9%	327,373	-6.6%	0.40%	+34.0%
SPRB	Buy	SPRUCE BIOSCIENCES INC	$1,288,494	+92.1%	570,130	+82.7%	0.40%	+119.1%
MREO	Sell	MEREO BIOPHARMA GROUP PLCspon ads	$1,241,642	-6.8%	962,513	-4.6%	0.39%	+6.0%
GOSS	New	GOSSAMER BIO INC	$1,229,256	–	1,476,052	–	0.38%	–
MGNX	New	MACROGENICS INC	$1,204,591	–	258,496	–	0.38%	–
CGEM	New	CULLINAN ONCOLOGY INC	$1,151,920	–	127,284	–	0.36%	–
STRO	Buy	SUTRO BIOPHARMA INC	$982,284	-13.0%	283,079	+16.6%	0.31%	-1.0%
MRSN	Sell	MERSANA THERAPEUTICS INC	$932,228	-65.1%	734,038	-9.5%	0.29%	-60.2%
	Buy	BIOHAVEN LTD	$910,350	+80.3%	35,000	+65.8%	0.28%	+105.1%
IMVT	New	IMMUNOVANT INC	$863,775	–	22,500	–	0.27%	–
NXTC	Sell	NEXTCURE INC	$214,379	-36.5%	166,185	-11.5%	0.07%	-27.2%
KNTE	Buy	KINNATE BIOPHARMA INC	$147,251	-39.4%	105,179	+31.2%	0.05%	-30.3%
	New	ACELYRIN INC	$74,241	–	7,300	–	0.02%	–
LCTX	Exit	LINEAGE CELL THERAPEUTICS IN	$0	–	-140,000	–	-0.05%	–
MDNA	Exit	MEDICENNA THERAPEUTICS CORP	$0	–	-660,000	–	-0.09%	–
	Exit	PARDES BIOSCIENCES INC	$0	–	-430,291	–	-0.21%	–
SURF	Exit	SURFACE ONCOLOGY INC	$0	–	-1,100,000	–	-0.26%	–
LYRA	Exit	LYRA THERAPEUTICS INC	$0	–	-361,084	–	-0.41%	–
	Exit	DICE THERAPEUTICS INC	$0	–	-127,585	–	-1.62%	–
SAGE	Exit	SAGE THERAPEUTICS INC	$0	–	-180,306	–	-2.32%	–
ISEE	Exit	IVERIC BIO INC	$0	–	-612,975	–	-6.59%	–

Q2 2023

			Value		Shares		↓ Weighting
XBI	New	SPDR S&P BIOTECH ETFetf	$47,008,000	–	565,000	–	12.85%	–
ISEE	New	IVERIC BIO INC	$24,114,437	–	612,975	–	6.59%	–
STXS	New	STEREOTAXIS INC	$20,931,248	–	13,680,554	–	5.72%	–
BPMC	New	BLUEPRINT MEDICINES CORP	$15,896,127	–	251,521	–	4.35%	–
RVMD	New	REVOLUTION MEDICINES INC	$13,703,624	–	512,285	–	3.75%	–
IBB	New	ISHARES NASDAQ BIOTECH INDXetf	$13,013,400	–	102,500	–	3.56%	–
ASND	New	ASCENDIS PHARMA A/Ssponsored adr	$12,067,671	–	135,212	–	3.30%	–
MORF	New	MORPHIC HOLDING INC	$11,852,863	–	206,748	–	3.24%	–
IDYA	New	IDEAYA BIOSCIENCES INC	$11,275,770	–	479,820	–	3.08%	–
CYTK	New	CYTOKINETICS INC	$10,853,783	–	332,734	–	2.97%	–
XENE	New	XENON PHARMACEUTICALS INC	$10,800,713	–	280,538	–	2.95%	–
MRUS	New	MERUS N V	$10,133,627	–	384,870	–	2.77%	–
SNDX	New	SYNDAX PHARMACEUTICALS INC	$9,436,772	–	450,873	–	2.58%	–
KRTX	New	KARUNA THERAPEUTICS INC	$9,145,215	–	42,173	–	2.50%	–
DXCM	New	DEXCOM INC	$8,681,108	–	67,552	–	2.37%	–
SAGE	New	SAGE THERAPEUTICS INC	$8,477,988	–	180,306	–	2.32%	–
NBIX	New	NEUROCRINE BIOSCIENCES INC	$7,036,195	–	74,615	–	1.92%	–
ATRC	New	ATRICURE INC	$6,196,111	–	125,529	–	1.69%	–
DAWN	New	DAY ONE BIOPHARMACEUTICALS I	$6,054,774	–	507,100	–	1.66%	–
	New	DICE THERAPEUTICS INC	$5,927,599	–	127,585	–	1.62%	–
NRIX	New	NURIX THERAPEUTICS INC	$5,561,383	–	556,695	–	1.52%	–
KALV	New	KALVISTA PHARMACEUTICALS INC	$5,499,288	–	611,032	–	1.50%	–
	New	2SEVENTY BIO INC	$5,023,730	–	496,416	–	1.37%	–
VKTX	New	VIKING THERAPEUTICS INC	$4,760,148	–	293,655	–	1.30%	–
ARAY	New	ACCURAY INC	$4,730,525	–	1,222,358	–	1.29%	–
RCUS	New	ARCUS BIOSCIENCES INC	$4,584,312	–	225,717	–	1.25%	–
IPSC	New	CENTURY THERAPEUTICS INC	$4,131,406	–	1,307,407	–	1.13%	–
EWTX	New	EDGEWISE THERAPEUTICS INC	$4,025,226	–	519,384	–	1.10%	–
BCRX	New	BIOCRYST PHARMACEUTICALS INC	$4,005,760	–	569,000	–	1.10%	–
ALEC	New	ALECTOR INC	$3,840,017	–	638,938	–	1.05%	–
KURA	New	KURA ONCOLOGY INC	$3,785,355	–	357,784	–	1.04%	–
	New	ASCENDIS PHARMA A/Snote 2.250% 4/0	$3,627,500	–	4,000,000	–	0.99%	–
MRTX	New	MIRATI THERAPEUTICS INC	$3,421,511	–	94,700	–	0.94%	–
BCYC	New	BICYCLE THERAPEUTICS PLCsponsored ads	$3,118,544	–	122,200	–	0.85%	–
AXGN	New	AXOGEN INC	$3,032,100	–	332,103	–	0.83%	–
	New	MEDIWOUND LTD	$2,746,581	–	257,653	–	0.75%	–
TNDM	New	TANDEM DIABETES CARE INC	$2,699,400	–	110,000	–	0.74%	–
MRSN	New	MERSANA THERAPEUTICS INC	$2,667,680	–	810,845	–	0.73%	–
AUTL	New	AUTOLUS THERAPEUTICS PLCspon ads	$2,214,338	–	930,394	–	0.60%	–
GLPG	New	GALAPAGOS NVspon adr	$2,141,766	–	52,675	–	0.59%	–
ACET	New	ADICET BIO INC	$1,936,841	–	797,054	–	0.53%	–
KROS	New	KEROS THERAPEUTICS INC	$1,915,019	–	47,661	–	0.52%	–
	New	REGULUS THERAPEUTICS INC	$1,633,242	–	1,111,049	–	0.45%	–
	New	VIGIL NEUROSCIENCE INC	$1,619,695	–	172,308	–	0.44%	–
PRQR	New	PROQR THERAPEUTICS N V	$1,523,743	–	940,582	–	0.42%	–
LYRA	New	LYRA THERAPEUTICS INC	$1,484,055	–	361,084	–	0.41%	–
MREO	New	MEREO BIOPHARMA GROUP PLCspon ads	$1,331,897	–	1,009,013	–	0.36%	–
ITOS	New	ITEOS THERAPEUTICS INC	$1,304,934	–	98,560	–	0.36%	–
BWAY	New	BRAINSWAY LTDsponsored ads	$1,150,673	–	504,681	–	0.32%	–
STRO	New	SUTRO BIOPHARMA INC	$1,128,922	–	242,779	–	0.31%	–
LRMR	New	LARIMAR THERAPEUTICS INC	$1,096,667	–	350,373	–	0.30%	–
	New	ASTRIA THERAPEUTICS INC	$1,063,349	–	127,653	–	0.29%	–
	New	ACRIVON THERAPEUTICS INC	$996,002	–	76,852	–	0.27%	–
SURF	New	SURFACE ONCOLOGY INC	$956,560	–	1,100,000	–	0.26%	–
	New	SYROS PHARMACEUTICALS INC	$837,516	–	265,878	–	0.23%	–
	New	PARDES BIOSCIENCES INC	$778,827	–	430,291	–	0.21%	–
NVRO	New	NEVRO CORP	$711,760	–	28,000	–	0.20%	–
ELEV	New	ELEVATION ONCOLOGY INC	$684,000	–	450,000	–	0.19%	–
STIM	New	NEURONETICS INC	$674,492	–	313,717	–	0.18%	–
SPRB	New	SPRUCE BIOSCIENCES INC	$670,800	–	312,000	–	0.18%	–
	New	BIOHAVEN LTD	$505,023	–	21,113	–	0.14%	–
MASI	New	MASIMO CORP	$493,650	–	3,000	–	0.14%	–
CMPX	New	COMPASS THERAPEUTICS INC	$371,685	–	116,882	–	0.10%	–
KPTI	New	KARYOPHARM THERAPEUTICS INC	$344,894	–	192,678	–	0.09%	–
NXTC	New	NEXTCURE INC	$337,853	–	187,696	–	0.09%	–
ADAP	New	ADAPTIMMUNE THERAPEUTICS PLCsponds adr	$324,734	–	351,064	–	0.09%	–
MDNA	New	MEDICENNA THERAPEUTICS CORP	$317,922	–	660,000	–	0.09%	–
	New	PROCEPT BIOROBOTICS CORP	$282,800	–	8,000	–	0.08%	–
KNTE	New	KINNATE BIOPHARMA INC	$242,942	–	80,179	–	0.07%	–
CGEN	New	COMPUGEN LTDord	$233,930	–	205,202	–	0.06%	–
LCTX	New	LINEAGE CELL THERAPEUTICS IN	$197,400	–	140,000	–	0.05%	–
SPRO	New	SPERO THERAPEUTICS INC	$181,250	–	125,000	–	0.05%	–
INGN	New	INOGEN INC	$173,250	–	15,000	–	0.05%	–

Q4 2022

			Value		Shares		↓ Weighting
PHAS	Exit	PHASEBIO PHARMACEUTICALS INC	$0	–	-321,856	–	-0.02%	–
CGEN	Exit	COMPUGEN LTDord	$0	–	-205,202	–	-0.04%	–
	Exit	REUNION NEUROSCIENCE INC	$0	–	-96,585	–	-0.04%	–
LCTX	Exit	LINEAGE CELL THERAPEUTICS IN	$0	–	-140,000	–	-0.04%	–
SPRO	Exit	SPERO THERAPEUTICS INC	$0	–	-125,000	–	-0.07%	–
BMEA	Exit	BIOMEA FUSION INC	$0	–	-34,625	–	-0.09%	–
MGNX	Exit	MACROGENICS INC	$0	–	-100,000	–	-0.09%	–
INGN	Exit	INOGEN INC	$0	–	-15,000	–	-0.10%	–
ADAP	Exit	ADAPTIMMUNE THERAPEUTICS PLCsponds adr	$0	–	-351,064	–	-0.10%	–
MASI	Exit	MASIMO CORP	$0	–	-3,000	–	-0.11%	–
CMPX	Exit	COMPASS THERAPEUTICS INC	$0	–	-188,094	–	-0.12%	–
VERO	Exit	VENUS CONCEPT INC	$0	–	-968,187	–	-0.12%	–
IKNA	Exit	IKENA ONCOLOGY INC	$0	–	-122,517	–	-0.12%	–
OTIC	Exit	OTONOMY INC	$0	–	-1,470,199	–	-0.12%	–
STRO	Exit	SUTRO BIOPHARMA INC	$0	–	-81,200	–	-0.12%	–
	Exit	THESEUS PHARMACEUTICALS INC	$0	–	-81,899	–	-0.13%	–
PRQR	Exit	PROQR THERAPEUTICS NV	$0	–	-649,383	–	-0.13%	–
CMPS	Exit	COMPASS PATHWAYS PLCsponsored ads	$0	–	-47,390	–	-0.14%	–
NXTC	Exit	NEXTCURE INC	$0	–	-187,696	–	-0.14%	–
BDTX	Exit	BLACK DIAMOND THERAPEUTICS I	$0	–	-313,600	–	-0.14%	–
MDNA	Exit	MEDICENNA THERAPEUTICS CORP	$0	–	-660,000	–	-0.15%	–
GHRS	Exit	GH RESEARCH PLCordinary shares	$0	–	-52,631	–	-0.16%	–
MEIP	Exit	MEI PHARMA INC	$0	–	-1,767,146	–	-0.18%	–
GNFT	Exit	GENFIT S Aads	$0	–	-187,940	–	-0.18%	–
BWAY	Exit	BRAINSWAY LTDsponsored ads	$0	–	-220,000	–	-0.21%	–
	Exit	PARDES BIOSCIENCES INC	$0	–	-479,386	–	-0.24%	–
KNTE	Exit	KINNATE BIOPHARMA INC	$0	–	-78,074	–	-0.25%	–
MREO	Exit	MEREO BIOPHARMA GROUP PLCspon ads	$0	–	-1,096,513	–	-0.25%	–
	Exit	REGULUS THERAPEUTICS INC	$0	–	-555,555	–	-0.25%	–
SCYX	Exit	SCYNEXIS INC	$0	–	-399,064	–	-0.26%	–
	Exit	BIOHAVEN LTD	$0	–	-153,564	–	-0.26%	–
GMDA	Exit	GAMIDA CELL LTD	$0	–	-614,896	–	-0.26%	–
NGM	Exit	NGM BIOPHARMACEUTICALS INC	$0	–	-74,953	–	-0.26%	–
STIM	Exit	NEURONETICS INC	$0	–	-313,717	–	-0.27%	–
AUTL	Exit	AUTOLUS THERAPEUTICS PLCspon ads	$0	–	-496,150	–	-0.29%	–
SURF	Exit	SURFACE ONCOLOGY INC	$0	–	-1,100,000	–	-0.31%	–
ORIC	Exit	ORIC PHARMACEUTICALS INC	$0	–	-413,526	–	-0.36%	–
AFMD	Exit	AFFIMED N V	$0	–	-686,282	–	-0.38%	–
KROS	Exit	KEROS THERAPEUTICS INC	$0	–	-39,000	–	-0.40%	–
	Exit	AERIE PHARMACEUTICALS INCnote 1.500%10/0	$0	–	-1,500,000	–	-0.40%	–
VKTX	Exit	VIKING THERAPEUTICS INC	$0	–	-552,400	–	-0.40%	–
	Exit	DICE THERAPEUTICS INC	$0	–	-78,500	–	-0.43%	–
	Exit	SYROS PHARMACEUTICALS INC	$0	–	-265,878	–	-0.46%	–
GLPG	Exit	GALAPAGOS NVspon adr	$0	–	-42,675	–	-0.49%	–
LRMR	Exit	LARIMAR THERAPEUTICS INC	$0	–	-574,996	–	-0.50%	–
ITOS	Exit	ITEOS THERAPEUTICS INC	$0	–	-97,560	–	-0.50%	–
ARAY	Exit	ACCURAY INC	$0	–	-941,800	–	-0.53%	–
	Exit	VIGIL NEUROSCIENCE INC	$0	–	-216,395	–	-0.53%	–
MDWD	Exit	MEDIWOUND LTD	$0	–	-1,428,571	–	-0.53%	–
MRSN	Exit	MERSANA THERAPEUTICS INC	$0	–	-377,763	–	-0.69%	–
ATRC	Exit	ATRICURE INC	$0	–	-72,029	–	-0.76%	–
KURA	Exit	KURA ONCOLOGY INC	$0	–	-206,329	–	-0.76%	–
BCYC	Exit	BICYCLE THERAPEUTICS PLCsponsored ads	$0	–	-122,200	–	-0.76%	–
FSTX	Exit	F-STAR THERAPEUTICS INC	$0	–	-576,881	–	-0.80%	–
KALV	Exit	KALVISTA PHARMACEUTICALS INC	$0	–	-255,313	–	-1.00%	–
ETNB	Exit	89BIO INC	$0	–	-654,862	–	-1.02%	–
AXGN	Exit	AXOGEN INC	$0	–	-332,103	–	-1.06%	–
CSII	Exit	CARDIOVASCULAR SYS INC	$0	–	-286,988	–	-1.07%	–
APLS	Exit	APELLIS PHARMACEUTICALS INC	$0	–	-65,946	–	-1.21%	–
AERI	Exit	AERIE PHARMACEUTICALS INC	$0	–	-307,232	–	-1.25%	–
RCUS	Exit	ARCUS BIOSCIENCES INC	$0	–	-178,717	–	-1.26%	–
IPSC	Exit	CENTURY THERAPEUTICS INC	$0	–	-475,367	–	-1.26%	–
MRTX	Exit	MIRATI THERAPEUTICS INC	$0	–	-71,600	–	-1.34%	–
ALEC	Exit	ALECTOR INC	$0	–	-532,438	–	-1.36%	–
MORF	Exit	MORPHIC HLDG INC	$0	–	-195,467	–	-1.49%	–
MRUS	Exit	MERUS N V	$0	–	-276,893	–	-1.49%	–
DXCM	Exit	DEXCOM INC	$0	–	-72,552	–	-1.57%	–
CBAY	Exit	CYMABAY THERAPEUTICS INC	$0	–	-1,703,235	–	-1.60%	–
KRTX	Exit	KARUNA THERAPEUTICS INC	$0	–	-28,886	–	-1.75%	–
SAGE	Exit	SAGE THERAPEUTICS INC	$0	–	-180,306	–	-1.90%	–
ISEE	Exit	IVERIC BIO INC	$0	–	-401,476	–	-1.94%	–
NRIX	Exit	NURIX THERAPEUTICS INC	$0	–	-566,695	–	-1.99%	–
EWTX	Exit	EDGEWISE THERAPEUTICS INC	$0	–	-781,112	–	-2.07%	–
IDYA	Exit	IDEAYA BIOSCIENCES INC	$0	–	-538,561	–	-2.16%	–
NBIX	Exit	NEUROCRINE BIOSCIENCES INC	$0	–	-80,155	–	-2.29%	–
SNDX	Exit	SYNDAX PHARMACEUTICALS INC	$0	–	-355,487	–	-2.30%	–
CYTK	Exit	CYTOKINETICS INC	$0	–	-183,995	–	-2.40%	–
RVMD	Exit	REVOLUTION MEDICINES INC	$0	–	-479,785	–	-2.54%	–
IBB	Exit	ISHARES TR NASDAQ BIOTECH INDXetf	$0	–	-102,500	–	-3.22%	–
FATE	Exit	FATE THERAPEUTICS INC	$0	–	-539,940	–	-3.25%	–
ACET	Exit	ADICET BIO INC	$0	–	-935,766	–	-3.58%	–
XENE	Exit	XENON PHARMACEUTICALS INC	$0	–	-375,223	–	-3.64%	–
ASND	Exit	ASCENDIS PHARMA A/Ssponsored adr	$0	–	-135,712	–	-3.77%	–
BHVN	Exit	BIOHAVEN PHARMACTL HLDG CO L	$0	–	-110,100	–	-4.48%	–
BPMC	Exit	BLUEPRINT MEDICINES CORP	$0	–	-261,235	–	-4.63%	–
STXS	Exit	STEREOTAXIS INC	$0	–	-13,680,554	–	-6.62%	–
XBI	Exit	SPDR SP BIOTECH ETFetf	$0	–	-566,000	–	-12.08%	–

Q3 2022

			Value		Shares		↓ Weighting
XBI	Sell	SPDR SP BIOTECH ETFetf	$44,895,000	-1.4%	566,000	-7.7%	12.08%	-2.7%
BPMC	Sell	BLUEPRINT MEDICINES CORP	$17,213,000	+30.4%	261,235	-0.0%	4.63%	+28.7%
ASND	Sell	ASCENDIS PHARMA A/Ssponsored adr	$14,014,000	+8.3%	135,712	-2.5%	3.77%	+6.9%
XENE	Sell	XENON PHARMACEUTICALS INC	$13,546,000	+1.5%	375,223	-14.5%	3.64%	+0.2%
FATE	Sell	FATE THERAPEUTICS INC	$12,100,000	-11.4%	539,940	-2.0%	3.25%	-12.6%
RVMD	Buy	REVOLUTION MEDICINES INC	$9,461,000	+61.9%	479,785	+60.0%	2.54%	+59.8%
CYTK	Sell	CYTOKINETICS INC	$8,915,000	+7.3%	183,995	-13.0%	2.40%	+5.9%
SNDX	Sell	SYNDAX PHARMACEUTICALS INC	$8,542,000	+19.7%	355,487	-4.2%	2.30%	+18.1%
NBIX	Sell	NEUROCRINE BIOSCIENCES INC	$8,513,000	+5.7%	80,155	-3.0%	2.29%	+4.3%
IDYA	Sell	IDEAYA BIOSCIENCES INC	$8,035,000	+6.1%	538,561	-1.8%	2.16%	+4.8%
EWTX	Buy	EDGEWISE THERAPEUTICS INC	$7,686,000	+38.7%	781,112	+12.2%	2.07%	+36.9%
ISEE	Sell	IVERIC BIO INC	$7,202,000	+86.0%	401,476	-0.2%	1.94%	+83.6%
KRTX	Sell	KARUNA THERAPEUTICS INC	$6,497,000	-17.2%	28,886	-53.4%	1.75%	-18.4%
CBAY	Sell	CYMABAY THERAPEUTICS INC	$5,961,000	+13.0%	1,703,235	-4.7%	1.60%	+11.6%
MRUS	Buy	MERUS N V	$5,546,000	-6.8%	276,893	+5.3%	1.49%	-8.0%
ALEC	Sell	ALECTOR INC	$5,037,000	-10.3%	532,438	-3.6%	1.36%	-11.4%
MRTX	Sell	MIRATI THERAPEUTICS INC	$5,001,000	-6.4%	71,600	-10.1%	1.34%	-7.7%
RCUS	Sell	ARCUS BIOSCIENCES INC	$4,675,000	-1.7%	178,717	-4.8%	1.26%	-3.1%
AERI	Buy	AERIE PHARMACEUTICALS INC	$4,648,000	+114.4%	307,232	+6.3%	1.25%	+111.5%
APLS	Sell	APELLIS PHARMACEUTICALS INC	$4,504,000	+2.8%	65,946	-32.0%	1.21%	+1.3%
ETNB	Sell	89BIO INC	$3,792,000	+53.6%	654,862	-14.6%	1.02%	+51.6%
KALV	Sell	KALVISTA PHARMACEUTICALS INC	$3,705,000	+41.7%	255,313	-3.9%	1.00%	+39.9%
BCYC	Sell	BICYCLE THERAPEUTICS PLCsponsored ads	$2,842,000	+29.1%	122,200	-6.9%	0.76%	+27.3%
KURA	Buy	KURA ONCOLOGY INC	$2,818,000	+30.5%	206,329	+75.1%	0.76%	+28.7%
MRSN	Sell	MERSANA THERAPEUTICS INC	$2,554,000	+35.9%	377,763	-7.1%	0.69%	+34.2%
MDWD	New	MEDIWOUND LTD	$1,986,000	–	1,428,571	–	0.53%	–
	Buy	VIGIL NEUROSCIENCE INC	$1,969,000	+666.1%	216,395	+116.9%	0.53%	+657.1%
ITOS	Sell	ITEOS THERAPEUTICS INC	$1,859,000	-14.3%	97,560	-7.3%	0.50%	-15.4%
LRMR	Buy	LARIMAR THERAPEUTICS INC	$1,840,000	+1777.6%	574,996	+1050.1%	0.50%	+1733.3%
	New	SYROS PHARMACEUTICALS INC	$1,712,000	–	265,878	–	0.46%	–
	Sell	DICE THERAPEUTICS INC	$1,592,000	-34.6%	78,500	-50.0%	0.43%	-35.5%
VKTX	Buy	VIKING THERAPEUTICS INC	$1,503,000	+12.5%	552,400	+19.5%	0.40%	+11.0%
ORIC	Sell	ORIC PHARMACEUTICALS INC	$1,323,000	-29.0%	413,526	-0.6%	0.36%	-29.9%
NGM	Sell	NGM BIOPHARMACEUTICALS INC	$980,000	-29.0%	74,953	-30.4%	0.26%	-29.8%
GMDA	New	GAMIDA CELL LTD	$978,000	–	614,896	–	0.26%	–
	New	BIOHAVEN LTD	$967,000	–	153,564	–	0.26%	–
SCYX	Sell	SCYNEXIS INC	$958,000	+13.4%	399,064	-12.2%	0.26%	+12.2%
KNTE	Sell	KINNATE BIOPHARMA INC	$933,000	-67.0%	78,074	-65.2%	0.25%	-67.4%
	Buy	PARDES BIOSCIENCES INC	$887,000	-36.0%	479,386	+6.3%	0.24%	-36.6%
BWAY	Buy	BRAINSWAY LTDsponsored ads	$794,000	-17.8%	220,000	+10.0%	0.21%	-18.6%
GHRS	Sell	GH RESEARCH PLCordinary shares	$612,000	+11.5%	52,631	-4.3%	0.16%	+10.0%
MDNA	New	MEDICENNA THERAPEUTICS CORP	$548,000	–	660,000	–	0.15%	–
CMPS	Sell	COMPASS PATHWAYS PLCsponsored ads	$508,000	-37.3%	47,390	-36.7%	0.14%	-38.0%
PRQR	New	PROQR THERAPEUTICS NV	$483,000	–	649,383	–	0.13%	–
STRO	Sell	SUTRO BIOPHARMA INC	$451,000	+2.3%	81,200	-4.1%	0.12%	+0.8%
IKNA	New	IKENA ONCOLOGY INC	$435,000	–	122,517	–	0.12%	–
CMPX	Sell	COMPASS THERAPEUTICS INC	$429,000	-18.3%	188,094	-5.0%	0.12%	-19.6%
MGNX	Sell	MACROGENICS INC	$346,000	-38.9%	100,000	-47.9%	0.09%	-39.6%
BMEA	Sell	BIOMEA FUSION INC	$339,000	-79.3%	34,625	-74.7%	0.09%	-79.6%
SPRO	New	SPERO THERAPEUTICS INC	$250,000	–	125,000	–	0.07%	–
	New	REUNION NEUROSCIENCE INC	$138,000	–	96,585	–	0.04%	–
PHAS	Sell	PHASEBIO PHARMACEUTICALS INC	$57,000	-74.9%	321,856	-15.0%	0.02%	-75.8%
ANNX	Exit	ANNEXON INC	$0	–	-40,796	–	-0.04%	–
ASLN	Exit	ASLAN PHARMACEUTICALS LTDads	$0	–	-343,720	–	-0.05%	–
CNTB	Exit	CONNECT BIOPHARMA HLDGS LTDads	$0	–	-250,000	–	-0.06%	–
MDGL	Exit	MADRIGAL PHARMACEUTICALS INC	$0	–	-3,100	–	-0.06%	–
LVTX	Exit	LAVA THERAPEUTICS NV	$0	–	-128,335	–	-0.10%	–
RIGL	Exit	RIGEL PHARMACEUTICALS INC	$0	–	-390,066	–	-0.12%	–
RDUS	Exit	RADIUS HEALTH INC	$0	–	-91,935	–	-0.26%	–
WVE	Exit	WAVE LIFE SCIENCES LTD	$0	–	-372,361	–	-0.33%	–
	Exit	FIELD TRIP HEALTH LTD	$0	–	-1,904,141	–	-0.44%	–
TPTX	Exit	TURNING POINT THERAPEUTICS I	$0	–	-48,452	–	-0.99%	–
	Exit	RADIUS HEALTH INCnote 3.000% 9/0	$0	–	-4,000,000	–	-1.07%	–
NTUS	Exit	NATUS MEDICAL INC	$0	–	-143,600	–	-1.28%	–

Q2 2022

			Value		Shares		↓ Weighting
XBI	New	SPDR SP BIOTECH ETFetf	$45,528,000	–	613,000	–	12.41%	–
STXS	New	STEREOTAXIS INC	$25,172,000	–	13,680,554	–	6.86%	–
BHVN	New	BIOHAVEN PHARMACTL HLDG CO L	$16,043,000	–	110,100	–	4.37%	–
ACET	New	ADICET BIO INC	$13,662,000	–	935,766	–	3.72%	–
FATE	New	FATE THERAPEUTICS INC	$13,652,000	–	550,940	–	3.72%	–
XENE	New	XENON PHARMACEUTICALS INC	$13,343,000	–	438,623	–	3.64%	–
BPMC	New	BLUEPRINT MEDICINES CORP	$13,197,000	–	261,280	–	3.60%	–
ASND	New	ASCENDIS PHARMA A/Ssponsored adr	$12,941,000	–	139,212	–	3.53%	–
IBB	New	ISHARES TR NASDAQ BIOTECH INDXetf	$12,057,000	–	102,500	–	3.29%	–
CYTK	New	CYTOKINETICS INC	$8,310,000	–	211,495	–	2.26%	–
NBIX	New	NEUROCRINE BIOSCIENCES INC	$8,057,000	–	82,655	–	2.20%	–
KRTX	New	KARUNA THERAPEUTICS INC	$7,850,000	–	62,053	–	2.14%	–
IDYA	New	IDEAYA BIOSCIENCES INC	$7,570,000	–	548,561	–	2.06%	–
NRIX	New	NURIX THERAPEUTICS INC	$7,180,000	–	566,695	–	1.96%	–
SNDX	New	SYNDAX PHARMACEUTICALS INC	$7,138,000	–	370,987	–	1.94%	–
MRUS	New	MERUS N V	$5,952,000	–	262,891	–	1.62%	–
RVMD	New	REVOLUTION MEDICINES INC	$5,843,000	–	299,785	–	1.59%	–
SAGE	New	SAGE THERAPEUTICS INC	$5,824,000	–	180,306	–	1.59%	–
ALEC	New	ALECTOR INC	$5,613,000	–	552,438	–	1.53%	–
EWTX	New	EDGEWISE THERAPEUTICS INC	$5,540,000	–	695,959	–	1.51%	–
DXCM	New	DEXCOM INC	$5,407,000	–	72,552	–	1.47%	–
MRTX	New	MIRATI THERAPEUTICS INC	$5,344,000	–	79,600	–	1.46%	–
CBAY	New	CYMABAY THERAPEUTICS INC	$5,273,000	–	1,787,569	–	1.44%	–
RCUS	New	ARCUS BIOSCIENCES INC	$4,757,000	–	187,717	–	1.30%	–
NTUS	New	NATUS MEDICAL INC	$4,706,000	–	143,600	–	1.28%	–
APLS	New	APELLIS PHARMACEUTICALS INC	$4,383,000	–	96,935	–	1.20%	–
MORF	New	MORPHIC HLDG INC	$4,242,000	–	195,467	–	1.16%	–
CSII	New	CARDIOVASCULAR SYS INC	$4,121,000	–	286,988	–	1.12%	–
IPSC	New	CENTURY THERAPEUTICS INC	$3,993,000	–	475,367	–	1.09%	–
	New	RADIUS HEALTH INCnote 3.000% 9/0	$3,916,000	–	4,000,000	–	1.07%	–
ISEE	New	IVERIC BIO INC	$3,872,000	–	402,476	–	1.06%	–
TPTX	New	TURNING POINT THERAPEUTICS I	$3,646,000	–	48,452	–	0.99%	–
FSTX	New	F-STAR THERAPEUTICS INC	$3,611,000	–	576,881	–	0.98%	–
OTIC	New	OTONOMY INC	$3,058,000	–	1,470,199	–	0.83%	–
ATRC	New	ATRICURE INC	$2,943,000	–	72,029	–	0.80%	–
KNTE	New	KINNATE BIOPHARMA INC	$2,830,000	–	224,451	–	0.77%	–
AXGN	New	AXOGEN INC	$2,720,000	–	332,103	–	0.74%	–
KALV	New	KALVISTA PHARMACEUTICALS INC	$2,614,000	–	265,663	–	0.71%	–
ETNB	New	89BIO INC	$2,469,000	–	766,774	–	0.67%	–
	New	DICE THERAPEUTICS INC	$2,435,000	–	156,904	–	0.66%	–
GLPG	New	GALAPAGOS NVspon adr	$2,381,000	–	42,675	–	0.65%	–
BCYC	New	BICYCLE THERAPEUTICS PLCsponsored ads	$2,202,000	–	131,200	–	0.60%	–
AERI	New	AERIE PHARMACEUTICALS INC	$2,168,000	–	289,040	–	0.59%	–
ITOS	New	ITEOS THERAPEUTICS INC	$2,169,000	–	105,298	–	0.59%	–
KURA	New	KURA ONCOLOGY INC	$2,160,000	–	117,829	–	0.59%	–
AFMD	New	AFFIMED N V	$1,901,000	–	686,282	–	0.52%	–
MRSN	New	MERSANA THERAPEUTICS INC	$1,879,000	–	406,763	–	0.51%	–
ORIC	New	ORIC PHARMACEUTICALS INC	$1,863,000	–	415,926	–	0.51%	–
ARAY	New	ACCURAY INC	$1,846,000	–	941,800	–	0.50%	–
SURF	New	SURFACE ONCOLOGY INC	$1,804,000	–	1,100,000	–	0.49%	–
BMEA	New	BIOMEA FUSION INC	$1,640,000	–	136,935	–	0.45%	–
	New	FIELD TRIP HEALTH LTD	$1,600,000	–	1,904,141	–	0.44%	–
AUTL	New	AUTOLUS THERAPEUTICS PLCspon ads	$1,404,000	–	496,150	–	0.38%	–
	New	PARDES BIOSCIENCES INC	$1,385,000	–	451,105	–	0.38%	–
NGM	New	NGM BIOPHARMACEUTICALS INC	$1,380,000	–	107,653	–	0.38%	–
VKTX	New	VIKING THERAPEUTICS INC	$1,336,000	–	462,400	–	0.36%	–
	New	AERIE PHARMACEUTICALS INCnote 1.500%10/0	$1,292,000	–	1,500,000	–	0.35%	–
MREO	New	MEREO BIOPHARMA GROUP PLCads	$1,228,000	–	1,096,513	–	0.34%	–
WVE	New	WAVE LIFE SCIENCES LTD	$1,210,000	–	372,361	–	0.33%	–
	New	REGULUS THERAPEUTICS INC	$1,150,000	–	555,555	–	0.31%	–
KROS	New	KEROS THERAPEUTICS INC	$1,078,000	–	39,000	–	0.29%	–
MEIP	New	MEI PHARMA INC	$1,069,000	–	1,767,146	–	0.29%	–
STIM	New	NEURONETICS INC	$1,007,000	–	313,717	–	0.27%	–
BWAY	New	BRAINSWAY LTDsponsored ads	$966,000	–	200,000	–	0.26%	–
RDUS	New	RADIUS HEALTH INC	$953,000	–	91,935	–	0.26%	–
NXTC	New	NEXTCURE INC	$882,000	–	187,696	–	0.24%	–
SCYX	New	SCYNEXIS INC	$845,000	–	454,492	–	0.23%	–
CMPS	New	COMPASS PATHWAYS PLCsponsored ads	$810,000	–	74,890	–	0.22%	–
BDTX	New	BLACK DIAMOND THERAPEUTICS I	$771,000	–	313,600	–	0.21%	–
GNFT	New	GENFIT S Aads	$605,000	–	187,940	–	0.16%	–
ADAP	New	ADAPTIMMUNE THERAPEUTICS PLCsponds adr	$597,000	–	351,064	–	0.16%	–
MGNX	New	MACROGENICS INC	$566,000	–	192,000	–	0.15%	–
GHRS	New	GH RESEARCH PLCordinary shares	$549,000	–	55,000	–	0.15%	–
CMPX	New	COMPASS THERAPEUTICS INC	$525,000	–	198,094	–	0.14%	–
	New	THESEUS PHARMACEUTICALS INC	$453,000	–	81,899	–	0.12%	–
VERO	New	VENUS CONCEPT INC	$449,000	–	968,187	–	0.12%	–
RIGL	New	RIGEL PHARMACEUTICALS INC	$441,000	–	390,066	–	0.12%	–
STRO	New	SUTRO BIOPHARMA INC	$441,000	–	84,700	–	0.12%	–
MASI	New	MASIMO CORP	$392,000	–	3,000	–	0.11%	–
CGEN	New	COMPUGEN LTDord	$380,000	–	205,202	–	0.10%	–
LVTX	New	LAVA THERAPEUTICS NV	$379,000	–	128,335	–	0.10%	–
INGN	New	INOGEN INC	$363,000	–	15,000	–	0.10%	–
	New	VIGIL NEUROSCIENCE INC	$257,000	–	99,754	–	0.07%	–
PHAS	New	PHASEBIO PHARMACEUTICALS INC	$227,000	–	378,611	–	0.06%	–
MDGL	New	MADRIGAL PHARMACEUTICALS INC	$222,000	–	3,100	–	0.06%	–
LCTX	New	LINEAGE CELL THERAPEUTICS IN	$221,000	–	140,000	–	0.06%	–
CNTB	New	CONNECT BIOPHARMA HLDGS LTDads	$218,000	–	250,000	–	0.06%	–
ASLN	New	ASLAN PHARMACEUTICALS LTDads	$170,000	–	343,720	–	0.05%	–
ANNX	New	ANNEXON INC	$154,000	–	40,796	–	0.04%	–
LRMR	New	LARIMAR THERAPEUTICS INC	$98,000	–	49,996	–	0.03%	–

Q4 2021

			Value		Shares		↓ Weighting
VBLT	Exit	VASCULAR BIOGENICS LTD	$0	–	-55,000	–	-0.03%	–
RDUS	Exit	RADIUS HEALTH INC	$0	–	-14,500	–	-0.05%	–
ANNX	Exit	ANNEXON INC	$0	–	-23,296	–	-0.12%	–
MDGL	Exit	MADRIGAL PHARMACEUTICALS INC	$0	–	-5,600	–	-0.12%	–
PHVS	Exit	PHARVARIS N V	$0	–	-35,074	–	-0.16%	–
SRGA	Exit	SURGALIGN HOLDINGS INC	$0	–	-579,710	–	-0.17%	–
INGN	Exit	INOGEN INC	$0	–	-15,000	–	-0.17%	–
GNFT	Exit	GENFIT S Aads	$0	–	-188,549	–	-0.18%	–
LRMR	Exit	LARIMAR THERAPEUTICS INC	$0	–	-64,487	–	-0.20%	–
INFI	Exit	INFINITY PHARMACEUTICALS INC	$0	–	-236,160	–	-0.21%	–
MASI	Exit	MASIMO CORP	$0	–	-3,000	–	-0.22%	–
LVTX	Exit	LAVA THERAPEUTICS NV	$0	–	-139,332	–	-0.22%	–
HARP	Exit	HARPOON THERAPEUTICS INC	$0	–	-105,163	–	-0.22%	–
ALPN	Exit	ALPINE IMMUNE SCIENCES INC	$0	–	-111,501	–	-0.32%	–
CGEN	Exit	COMPUGEN LTDord	$0	–	-201,502	–	-0.32%	–
NXTC	Exit	NEXTCURE INC	$0	–	-183,491	–	-0.33%	–
BOLT	Exit	BOLT BIOTHERAPEUTICS INC	$0	–	-100,000	–	-0.34%	–
ASLN	Exit	ASLAN PHARMACEUTICALS LTDads	$0	–	-732,500	–	-0.35%	–
MRSN	Exit	MERSANA THERAPEUTICS INC	$0	–	-140,263	–	-0.35%	–
NGM	Exit	NGM BIOPHARMACEUTICALS INC	$0	–	-65,485	–	-0.36%	–
	Exit	AERIE PHARMACEUTICALS INCnote 1.500%10/0	$0	–	-1,500,000	–	-0.36%	–
ATHA	Exit	ATHIRA PHARMA INC	$0	–	-160,983	–	-0.40%	–
SNDX	Exit	SYNDAX PHARMACEUTICALS INC	$0	–	-80,702	–	-0.41%	–
IFRX	Exit	INFLARX NV	$0	–	-600,000	–	-0.41%	–
	Exit	FIELD TRIP HEALTH LTD	$0	–	-340,900	–	-0.42%	–
STRO	Exit	SUTRO BIOPHARMA INC	$0	–	-85,000	–	-0.43%	–
BWAY	Exit	BRAINWAY LTDsponsored ads	$0	–	-200,000	–	-0.43%	–
MEIP	Exit	MEI PHARMA INC	$0	–	-641,000	–	-0.47%	–
PHAS	Exit	PHASEBIO PHARMACEUTICALS INC	$0	–	-603,042	–	-0.50%	–
COGT	Exit	COGENT BIOSCIENCES INC	$0	–	-223,554	–	-0.50%	–
MGNX	Exit	MACROGENICS INC	$0	–	-90,000	–	-0.50%	–
KURA	Exit	KURA ONCOLOGY INC	$0	–	-100,829	–	-0.50%	–
HOOK	Exit	HOOKIPA PHARMA INC	$0	–	-322,124	–	-0.50%	–
CBAY	Exit	CYMABAY THERAPEUTICS INC	$0	–	-524,286	–	-0.51%	–
IPSC	Exit	CENTURY THERAPEUTICS INC	$0	–	-80,000	–	-0.53%	–
STIM	Exit	NEURONETICS INC	$0	–	-313,717	–	-0.55%	–
ITOS	Exit	ITEOS THERAPEUTICS INC	$0	–	-83,061	–	-0.60%	–
NTUS	Exit	NATUS MED INC	$0	–	-95,653	–	-0.64%	–
ALEC	Exit	ALECTOR INC	$0	–	-107,412	–	-0.65%	–
KNTE	Exit	KINNATE BIOPHARMA INC	$0	–	-106,453	–	-0.65%	–
PRQR	Exit	PROQR THERAPEUTICS N V	$0	–	-296,383	–	-0.66%	–
ETNB	Exit	89BIO INC	$0	–	-126,652	–	-0.66%	–
MREO	Exit	MEREO BIOPHARMA GROUP PLCads	$0	–	-1,126,613	–	-0.72%	–
KDMN	Exit	KADMON HLDGS INC	$0	–	-314,561	–	-0.73%	–
TPTX	Exit	TURNING POINT THERAPEUTICS I	$0	–	-41,952	–	-0.74%	–
VERO	Exit	VENUS CONCEPT INC	$0	–	-1,113,228	–	-0.74%	–
VKTX	Exit	VIKING THERAPEUTICS INC	$0	–	-447,400	–	-0.75%	–
MRUS	Exit	MERUS N V	$0	–	-131,949	–	-0.77%	–
RIGL	Exit	RIGEL PHARMACEUTICALS INC	$0	–	-809,000	–	-0.78%	–
ACET	Exit	ADICET BIO INC	$0	–	-376,281	–	-0.78%	–
FSII	Exit	FS DEVELOPMENT CORP II	$0	–	-299,950	–	-0.79%	–
AERI	Exit	AERIE PHARMACEUTICALS INC	$0	–	-289,040	–	-0.87%	–
KALV	Exit	KALVISTA PHARMACEUTICALS INC	$0	–	-189,163	–	-0.88%	–
ISEE	Exit	IVERIC BIO INC	$0	–	-216,351	–	-0.93%	–
	Exit	RADIUS HEALTH INCnote 3.000% 9/0	$0	–	-4,000,000	–	-0.96%	–
ARAY	Exit	ACCURAY INC	$0	–	-941,800	–	-0.99%	–
GLPG	Exit	GALAPAGOS NVspon adr	$0	–	-77,675	–	-1.08%	–
RCUS	Exit	ARCUS BIOSCIENCES INC	$0	–	-123,700	–	-1.14%	–
OTIC	Exit	OTONOMY INC	$0	–	-2,379,392	–	-1.21%	–
ATRC	Exit	ATRICURE INC	$0	–	-72,029	–	-1.33%	–
FSTX	Exit	F-STAR THERAPEUTICS INC	$0	–	-693,785	–	-1.35%	–
RVMD	Exit	REVOLUTION MEDICINES INC	$0	–	-209,731	–	-1.53%	–
AFMD	Exit	AFFIMED N V	$0	–	-964,857	–	-1.58%	–
XENE	Exit	XENON PHARMACEUTICALS INC	$0	–	-406,535	–	-1.65%	–
CYTK	Exit	CYTOKINETICS INC	$0	–	-175,000	–	-1.66%	–
CSII	Exit	CARDIOVASCULAR SYS INC	$0	–	-193,741	–	-1.69%	–
IBB	Exit	ISHARES TR NASDAQ BIOTECHetf	$0	–	-40,900	–	-1.75%	–
ARNA	Exit	ARENA PHARMACEUTICALS INC	$0	–	-119,615	–	-1.89%	–
SAGE	Exit	SAGE THERAPEUTICS INC	$0	–	-180,306	–	-2.12%	–
NBIX	Exit	NEUROCRINE BIOSCIENCES INC	$0	–	-84,655	–	-2.15%	–
KRTX	Exit	KARUNA THERAPEUTICS INC	$0	–	-74,585	–	-2.42%	–
NRIX	Exit	NURIX THERAPEUTICS INC	$0	–	-306,320	–	-2.44%	–
MORF	Exit	MORPHIC HLDG INC	$0	–	-181,467	–	-2.73%	–
DXCM	Exit	DEXCOM INC	$0	–	-21,138	–	-3.07%	–
IDYA	Exit	IDEAYA BIOSCIENCES INC	$0	–	-460,061	–	-3.11%	–
DRNA	Exit	DICERNA PHARMACEUTICALS INC	$0	–	-587,456	–	-3.14%	–
BHVN	Exit	BIOHAVEN PHARMACTL HLDG CO L	$0	–	-88,100	–	-3.25%	–
FATE	Exit	FATE THERAPEUTICS INC	$0	–	-344,360	–	-5.42%	–
BPMC	Exit	BLUEPRINT MEDICINES CORP	$0	–	-206,911	–	-5.64%	–
STXS	Exit	STEREOTAXIS INC	$0	–	-13,680,554	–	-19.53%	–

Q3 2021

			Value		Shares		↓ Weighting
BPMC	Sell	BLUEPRINT MEDICINES CORP	$21,273,000	+16.3%	206,911	-0.5%	5.64%	+47.6%
FATE	Buy	FATE THERAPEUTICS INC	$20,410,000	-25.2%	344,360	+9.5%	5.42%	-5.1%
BHVN	Sell	BIOHAVEN PHARMACTL HLDG CO L	$12,238,000	+34.0%	88,100	-6.4%	3.25%	+70.0%
DRNA	Buy	DICERNA PHARMACEUTICALS INC	$11,843,000	-37.9%	587,456	+15.0%	3.14%	-21.2%
IDYA	Buy	IDEAYA BIOSCIENCES INC	$11,727,000	+68.4%	460,061	+38.7%	3.11%	+113.7%
KRTX	Buy	KARUNA THERAPEUTICS INC	$9,124,000	+51.0%	74,585	+40.7%	2.42%	+91.7%
NBIX	Buy	NEUROCRINE BIOSCIENCES INC	$8,119,000	+13.3%	84,655	+14.9%	2.15%	+43.7%
SAGE	Buy	SAGE THERAPEUTICS INC	$7,989,000	-17.4%	180,306	+5.9%	2.12%	+4.8%
CSII	Buy	CARDIOVASCULAR SYS INC	$6,361,000	-0.4%	193,741	+29.4%	1.69%	+26.4%
CYTK	New	CYTOKINETICS INC	$6,255,000	–	175,000	–	1.66%	–
FSTX	Sell	F-STAR THERAPEUTICS INC	$5,079,000	-17.2%	693,785	-2.9%	1.35%	+5.0%
ATRC	Sell	ATRICURE INC	$5,010,000	-31.0%	72,029	-21.3%	1.33%	-12.5%
RCUS	Buy	ARCUS BIOSCIENCES INC	$4,313,000	+31.2%	123,700	+3.3%	1.14%	+66.5%
ISEE	Buy	IVERIC BIO INC	$3,514,000	+209.6%	216,351	+20.2%	0.93%	+293.2%
KALV	Buy	KALVISTA PHARMACEUTICALS INC	$3,301,000	+127.3%	189,163	+212.2%	0.88%	+188.2%
FSII	Sell	FS DEVELOPMENT CORP II	$2,985,000	-0.3%	299,950	-0.0%	0.79%	+26.5%
RIGL	Buy	RIGEL PHARMACEUTICALS INC	$2,937,000	+177.3%	809,000	+231.6%	0.78%	+252.5%
MRUS	Sell	MERUS N V	$2,903,000	-12.7%	131,949	-16.4%	0.77%	+10.6%
VERO	Sell	VENUS CONCEPT INC	$2,794,000	-24.2%	1,113,228	-6.1%	0.74%	-3.9%
TPTX	Sell	TURNING POINT THERAPEUTICS I	$2,787,000	-25.3%	41,952	-12.3%	0.74%	-5.4%
KDMN	Sell	KADMON HLDGS INC	$2,740,000	+79.4%	314,561	-20.3%	0.73%	+127.9%
PRQR	Sell	PROQR THERAPEUTICS N V	$2,481,000	-64.3%	296,383	-71.3%	0.66%	-54.8%
ETNB	Buy	89BIO INC	$2,481,000	+13.9%	126,652	+8.8%	0.66%	+44.3%
ALEC	New	ALECTOR INC	$2,451,000	–	107,412	–	0.65%	–
KNTE	Buy	KINNATE BIOPHARMA INC	$2,451,000	+93.4%	106,453	+95.6%	0.65%	+145.3%
ITOS	New	ITEOS THERAPEUTICS INC	$2,243,000	–	83,061	–	0.60%	–
STIM	Buy	NEURONETICS INC	$2,058,000	-49.4%	313,717	+23.6%	0.55%	-35.8%
CBAY	Buy	CYMABAY THERAPEUTICS INC	$1,914,000	-14.0%	524,286	+2.7%	0.51%	+9.2%
KURA	Buy	KURA ONCOLOGY INC	$1,889,000	+8.4%	100,829	+20.7%	0.50%	+37.6%
MGNX	New	MACROGENICS INC	$1,885,000	–	90,000	–	0.50%	–
	New	FIELD TRIP HEALTH LTD	$1,565,000	–	340,900	–	0.42%	–
SNDX	Sell	SYNDAX PHARMACEUTICALS INC	$1,542,000	-39.2%	80,702	-45.4%	0.41%	-22.8%
NGM	Buy	NGM BIOPHARMACEUTICALS INC	$1,376,000	+129.0%	65,485	+114.7%	0.36%	+189.7%
MRSN	Buy	MERSANA THERAPEUTICS INC	$1,323,000	-24.1%	140,263	+9.4%	0.35%	-3.6%
ASLN	Buy	ASLAN PHARMACEUTICALS LTDads	$1,304,000	-41.7%	732,500	+8.1%	0.35%	-26.1%
ALPN	Sell	ALPINE IMMUNE SCIENCES INC	$1,190,000	+16.7%	111,501	-1.6%	0.32%	+48.4%
LVTX	Buy	LAVA THERAPEUTICS NV	$825,000	-44.1%	139,332	+2.7%	0.22%	-29.1%
INFI	Sell	INFINITY PHARMACEUTICALS INC	$808,000	-41.2%	236,160	-48.6%	0.21%	-25.4%
LRMR	Sell	LARIMAR THERAPEUTICS INC	$744,000	-1.6%	64,487	-16.2%	0.20%	+24.7%
PHVS	New	PHARVARIS N V	$622,000	–	35,074	–	0.16%	–
ANNX	New	ANNEXON INC	$434,000	–	23,296	–	0.12%	–
VBLT	Sell	VASCULAR BIOGENICS LTD	$113,000	-84.6%	55,000	-82.1%	0.03%	-80.5%
CNTB	Exit	CONNECT BIOPHARMA HLDGS LTDads	$0	–	-8,000	–	-0.03%	–
SCPH	Exit	SCPHARMACEUTICALS INC	$0	–	-38,891	–	-0.05%	–
APLS	Exit	APELLIS PHARMACEUTICALS INC	$0	–	-12,703	–	-0.17%	–
ASND	Exit	ASCENDIS PHARMA A Ssponsored adr	$0	–	-7,137	–	-0.20%	–
CFMS	Exit	CONFORMIS INC	$0	–	-1,300,000	–	-0.31%	–
ACRS	Exit	ACLARIS THERAPEUTICS INC	$0	–	-100,000	–	-0.37%	–
RDHL	Exit	REDHILL BIOPHARMA LTDsponsored ads	$0	–	-455,933	–	-0.66%	–
CARA	Exit	CARA THERAPEUTICS INC	$0	–	-315,000	–	-0.94%	–
LMNX	Exit	LUMINEX CORP	$0	–	-139,091	–	-1.07%	–
TBIO	Exit	TRANSLATE BIO INC	$0	–	-376,993	–	-2.17%	–
TBPH	Exit	THERAVANCE BIOPHARMA INC	$0	–	-732,345	–	-2.22%	–

Q2 2021

			Value		Shares		↓ Weighting
STXS	New	STEREOTAXIS INC	$131,881,000	–	13,680,554	–	27.58%	–
FATE	New	FATE THERAPEUTICS INC	$27,283,000	–	314,360	–	5.71%	–
DRNA	New	DICERNA PHARMACEUTICALS INC	$19,061,000	–	510,756	–	3.99%	–
BPMC	New	BLUEPRINT MEDICINES CORP	$18,288,000	–	207,911	–	3.82%	–
TBPH	New	THERAVANCE BIOPHARMA INC	$10,634,000	–	732,345	–	2.22%	–
MORF	New	MORPHIC HOLDING INC	$10,414,000	–	181,467	–	2.18%	–
TBIO	New	TRANSLATE BIO INC	$10,382,000	–	376,993	–	2.17%	–
SAGE	New	SAGE THERAPEUTICS INC	$9,675,000	–	170,306	–	2.02%	–
BHVN	New	BIOHAVEN PHARMACEUTICALS HOLD	$9,135,000	–	94,100	–	1.91%	–
DXCM	New	DEXCOM INC	$9,026,000	–	21,138	–	1.89%	–
AFMD	New	AFFIMED N V	$8,201,000	–	964,857	–	1.72%	–
ARNA	New	ARENA PHARMACEUTICALS INC	$8,158,000	–	119,615	–	1.71%	–
NRIX	New	NURIX THERAPEUTICS INC	$8,127,000	–	306,320	–	1.70%	–
XENE	New	XENON PHARMACEUTICALS INC	$7,570,000	–	406,535	–	1.58%	–
ATRC	New	ATRICURE INC	$7,261,000	–	91,529	–	1.52%	–
NBIX	New	NEUROCRINE BIOSCIENCES INC	$7,168,000	–	73,655	–	1.50%	–
IDYA	New	IDEAYA BIOSCIENCES INC	$6,962,000	–	331,661	–	1.46%	–
PRQR	New	PROQR THERAPEUTICS N V	$6,955,000	–	1,031,880	–	1.46%	–
IBB	New	ISHARES TR NASDAQ BIOTECHetf	$6,693,000	–	40,900	–	1.40%	–
RVMD	New	REVOLUTION MEDICINES INC	$6,657,000	–	209,731	–	1.39%	–
CSII	New	CARDIOVASCULAR SYSTEMS INC	$6,385,000	–	149,700	–	1.34%	–
FSTX	New	F-STAR THERAPEUTICS INC	$6,136,000	–	714,285	–	1.28%	–
KRTX	New	KARUNA THERAPEUTICS INC	$6,041,000	–	53,000	–	1.26%	–
GLPG	New	GALAPAGOS NVspon adr	$5,351,000	–	77,675	–	1.12%	–
OTIC	New	OTONOMY INC	$5,306,000	–	2,379,392	–	1.11%	–
LMNX	New	LUMINEX CORP	$5,119,000	–	139,091	–	1.07%	–
AERI	New	AERIE PHARMACEUTICALS INC	$4,628,000	–	289,040	–	0.97%	–
CARA	New	CARA THERAPEUTICS INC	$4,495,000	–	315,000	–	0.94%	–
ARAY	New	ACCURAY INC	$4,257,000	–	941,800	–	0.89%	–
STIM	New	NEURONETICS INC	$4,065,000	–	253,717	–	0.85%	–
ACET	New	ADICET BIO INC	$3,872,000	–	376,281	–	0.81%	–
TPTX	New	TURNING POINT THERAPEUTICS I	$3,733,000	–	47,852	–	0.78%	–
	New	RADIUS HEALTH INCnote 3.000% 9/0	$3,711,000	–	4,000,000	–	0.78%	–
VERO	New	VENUS CONCEPT INC	$3,686,000	–	1,185,100	–	0.77%	–
MREO	New	MEREO BIOPHARMA GROUP PLCads	$3,571,000	–	1,126,613	–	0.75%	–
MRUS	New	MERUS N V	$3,326,000	–	157,841	–	0.70%	–
RCUS	New	ARCUS BIOSCIENCES INC	$3,287,000	–	119,700	–	0.69%	–
RDHL	New	REDHILL BIOPHARMA LTDsponsored ads	$3,137,000	–	455,933	–	0.66%	–
FSII	New	FS DEVELOPMENT CORP II	$2,994,000	–	300,000	–	0.63%	–
HOOK	New	HOOKIPA PHARMA INC	$2,951,000	–	322,124	–	0.62%	–
VKTX	New	VIKING THERAPEUTICS INC	$2,680,000	–	447,400	–	0.56%	–
SNDX	New	SYNDAX PHARMACEUTICALS INC	$2,536,000	–	147,702	–	0.53%	–
NTUS	New	NATUS MEDICAL INC	$2,485,000	–	95,653	–	0.52%	–
IPSC	New	CENTURY THERAPEUTICS INC	$2,347,000	–	80,000	–	0.49%	–
PHAS	New	PHASEBIO PHARMACEUTICALS INC	$2,243,000	–	603,042	–	0.47%	–
ASLN	New	ASLAN PHARMACEUTICALS LTDads	$2,236,000	–	677,500	–	0.47%	–
CBAY	New	CYMABAY THERAPEUTICS INC	$2,225,000	–	510,386	–	0.46%	–
ETNB	New	89BIO INC	$2,178,000	–	116,452	–	0.46%	–
BWAY	New	BRAINWAY LTDsponsored ads	$2,040,000	–	200,000	–	0.43%	–
MEIP	New	MEI PHARMA INC	$1,827,000	–	641,000	–	0.38%	–
COGT	New	COGENT BIOSCIENCES INC	$1,813,000	–	223,554	–	0.38%	–
IFRX	New	INFLARX NV	$1,782,000	–	600,000	–	0.37%	–
ACRS	New	ACLARIS THERAPEUTICS INC	$1,756,000	–	100,000	–	0.37%	–
KURA	New	KURA ONCOLOGY INC	$1,742,000	–	83,529	–	0.36%	–
MRSN	New	MERSANA THERAPEUTICS INC	$1,742,000	–	128,263	–	0.36%	–
CGEN	New	COMPUGEN LTDord	$1,668,000	–	201,502	–	0.35%	–
ATHA	New	ATHIRA PHARMA INC	$1,648,000	–	160,983	–	0.34%	–
STRO	New	SUTRO BIOPHARMA INC	$1,580,000	–	85,000	–	0.33%	–
BOLT	New	BOLT BIOTHERAPEUTICS INC	$1,546,000	–	100,000	–	0.32%	–
KDMN	New	KADMON HOLDINGS INC	$1,527,000	–	394,561	–	0.32%	–
CFMS	New	CONFORMIS INC	$1,495,000	–	1,300,000	–	0.31%	–
	New	AERIE PHARMACEUTICALS INCnote 1.500%10/0	$1,497,000	–	1,500,000	–	0.31%	–
LVTX	New	LAVA THERAPEUTICS BV	$1,476,000	–	135,632	–	0.31%	–
NXTC	New	NEXTCURE INC	$1,473,000	–	183,491	–	0.31%	–
HARP	New	HARPOON THERAPEUTICS INC	$1,459,000	–	105,163	–	0.30%	–
KALV	New	KALVISTA PHARMACEUTICALS INC	$1,452,000	–	60,600	–	0.30%	–
INFI	New	INFINITY PHARMACEUTICALS INC	$1,373,000	–	459,260	–	0.29%	–
KNTE	New	KINNATE BIOPHARMA INC	$1,267,000	–	54,415	–	0.26%	–
ISEE	New	IVERIC BIO INC	$1,135,000	–	179,951	–	0.24%	–
RIGL	New	RIGEL PHARMACEUTICALS INC	$1,059,000	–	244,000	–	0.22%	–
ALPN	New	ALPINE IMMUNE SCIENCES INC	$1,020,000	–	113,302	–	0.21%	–
INGN	New	INOGEN INC	$978,000	–	15,000	–	0.20%	–
ASND	New	ASCENDIS PHARMA A Ssponsored adr	$939,000	–	7,137	–	0.20%	–
SRGA	New	SURGALIGN HOLDINGS INC	$806,000	–	579,710	–	0.17%	–
APLS	New	APELLIS PHARMACEUTICALS INC	$803,000	–	12,703	–	0.17%	–
LRMR	New	LARIMAR THERAPEUTICS INC	$756,000	–	76,987	–	0.16%	–
VBLT	New	VASCULAR BIOGENICS LTD	$734,000	–	306,980	–	0.15%	–
MASI	New	MASIMO CORPORATION	$727,000	–	3,000	–	0.15%	–
GNFT	New	GENFIT S Aads	$716,000	–	188,549	–	0.15%	–
NGM	New	NGM BIOPHARMACEUTICALS INC	$601,000	–	30,502	–	0.13%	–
MDGL	New	MADRIGAL PHARMACEUTICALS INC	$545,000	–	5,600	–	0.11%	–
RDUS	New	RADIUS HEALTH INC	$264,000	–	14,500	–	0.06%	–
SCPH	New	SCPHARMACEUTICALS INC	$238,000	–	38,891	–	0.05%	–
CNTB	New	CONNECT BIOPHARMA HLDGS LTDads	$156,000	–	8,000	–	0.03%	–

Q4 2020

			Value		Shares		↓ Weighting
CRDF	Exit	CARDIFF ONCOLOGY INC	$0	–	-5,000	–	-0.02%	–
LCTX	Exit	LINEAGE CELL THERAPEUTICS INC	$0	–	-95,000	–	-0.03%	–
ASLN	Exit	ASLAN PHARMACEUTICALS LTDads	$0	–	-86,082	–	-0.05%	–
HOOK	Exit	HOOKIPA PHARMA INC	$0	–	-22,061	–	-0.07%	–
RDUS	Exit	RADIUS HEALTH INC	$0	–	-22,000	–	-0.08%	–
INGN	Exit	INOGEN INC	$0	–	-15,000	–	-0.14%	–
ZYME	Exit	ZYMEWORKS INC	$0	–	-9,950	–	-0.15%	–
MREO	Exit	MEREO BIOPHARMA GROUP PLCads	$0	–	-199,425	–	-0.17%	–
GMDA	Exit	GAMIDA CELL LTD	$0	–	-140,000	–	-0.19%	–
ASMB	Exit	ASSEMBLY BIOSCIENCES INC	$0	–	-35,573	–	-0.19%	–
CHMA	Exit	CHIASMA INC	$0	–	-153,208	–	-0.21%	–
DMAC	Exit	DIAMEDICA THERAPEUTICS INC	$0	–	-156,529	–	-0.22%	–
SCPH	Exit	SCPHARMACEUTICALS INC	$0	–	-90,900	–	-0.22%	–
MASI	Exit	MASIMO CORPORATION	$0	–	-3,000	–	-0.23%	–
KRTX	Exit	KARUNA THERAPEUTICS INC	$0	–	-9,231	–	-0.23%	–
NTUS	Exit	NATUS MEDICAL INC	$0	–	-42,900	–	-0.24%	–
NXTC	Exit	NEXTCURE INC	$0	–	-85,000	–	-0.24%	–
ARDX	Exit	ARDELYX INC	$0	–	-144,650	–	-0.25%	–
PRVL	Exit	PREVAIL THERAPEUTICS INC	$0	–	-75,000	–	-0.25%	–
MDGL	Exit	MADRIGAL PHARMACEUTICALS INC	$0	–	-6,600	–	-0.26%	–
AXGT	Exit	AXOVANT SCIENCES LTD	$0	–	-171,083	–	-0.26%	–
ACET	Exit	ADICET BIO INC	$0	–	-67,577	–	-0.26%	–
AKBA	Exit	AKEBIA THERAPEUTICS INC	$0	–	-341,779	–	-0.28%	–
APLS	Exit	APELLIS PHARMACEUTICALS INC	$0	–	-30,054	–	-0.30%	–
VRNA	Exit	VERONA PHARMA PLCsponsored ads	$0	–	-161,507	–	-0.33%	–
SPRO	Exit	SPERO THERAPEUTICS INC	$0	–	-100,000	–	-0.36%	–
PHAS	Exit	PHASEBIO PHARMACEUTICALS INC	$0	–	-320,542	–	-0.37%	–
STRO	Exit	SUTRO BIOPHARMA INC	$0	–	-118,940	–	-0.39%	–
KURA	Exit	KURA ONCOLOGY INC	$0	–	-39,019	–	-0.39%	–
LRMR	Exit	LARIMAR THERAPEUTICS INC	$0	–	-79,155	–	-0.39%	–
	Exit	AERIE PHARMACEUTICALS INCnote 1.500%10/0	$0	–	-1,500,000	–	-0.39%	–
RCUS	Exit	ARCUS BIOSCIENCES INC	$0	–	-72,100	–	-0.40%	–
ALPN	Exit	ALPINE IMMUNE SCIENCES INC	$0	–	-148,260	–	-0.42%	–
JNJ	Exit	JOHNSON AND JOHNSON	$0	–	-9,400	–	-0.46%	–
HARP	Exit	HARPOON THERAPEUTICS INC	$0	–	-85,119	–	-0.47%	–
ALEC	Exit	ALECTOR INC	$0	–	-140,000	–	-0.48%	–
SNDX	Exit	SYNDAX PHARMACEUTICALS INC	$0	–	-102,713	–	-0.49%	–
BLUE	Exit	BLUEBIRD BIO INC	$0	–	-30,273	–	-0.53%	–
ISEE	Exit	IVERIC BIO INC	$0	–	-322,500	–	-0.59%	–
CGEN	Exit	COMPUGEN LTDord	$0	–	-115,202	–	-0.61%	–
MEIP	Exit	MEI PHARMA INC	$0	–	-666,000	–	-0.68%	–
SPPI	Exit	SPECTRUM PHARMACEUTICALS INC	$0	–	-514,891	–	-0.68%	–
KDMN	Exit	KADMON HOLDINGS INC	$0	–	-563,564	–	-0.72%	–
STIM	Exit	NEURONETICS INC	$0	–	-495,772	–	-0.78%	–
BCRX	Exit	BIOCRYST PHARMACEUTICALS INC	$0	–	-749,051	–	-0.84%	–
ARAY	Exit	ACCURAY INC	$0	–	-1,074,300	–	-0.84%	–
TBIO	Exit	TRANSLATE BIO INC	$0	–	-190,930	–	-0.84%	–
KALV	Exit	KALVISTA PHARMACEUTICALS INC	$0	–	-208,054	–	-0.85%	–
VKTX	Exit	VIKING THERAPEUTICS INC	$0	–	-450,900	–	-0.85%	–
BEAT	Exit	BIOTELEMETRY INC	$0	–	-60,500	–	-0.90%	–
OTIC	Exit	OTONOMY INC	$0	–	-689,100	–	-0.91%	–
LQDA	Exit	LIQUIDIA TECHNOLOGIES INC	$0	–	-575,000	–	-0.92%	–
ETNB	Exit	89BIO INC	$0	–	-110,478	–	-0.92%	–
MRSN	Exit	MERSANA THERAPEUTICS INC	$0	–	-152,763	–	-0.92%	–
AFMD	Exit	AFFIMED NV	$0	–	-924,278	–	-1.02%	–
CARA	Exit	CARA THERAPEUTICS INC	$0	–	-247,377	–	-1.02%	–
	Exit	RADIUS HEALTH INCnote 3.000% 9/0	$0	–	-4,000,000	–	-1.08%	–
AERI	Exit	AERIE PHARMACEUTICALS INC	$0	–	-284,440	–	-1.09%	–
CNST	Exit	CONSTELLATION PHARMACEUTICAL	$0	–	-180,942	–	-1.19%	–
XENE	Exit	XENON PHARMACEUTICALS INC	$0	–	-346,535	–	-1.25%	–
LMNX	Exit	LUMINEX CORP	$0	–	-154,091	–	-1.32%	–
IDYA	Exit	IDEAYA BIOSCIENCES INC	$0	–	-331,661	–	-1.35%	–
ASND	Exit	ASCENDIS PHARMA A Ssponsored adr	$0	–	-29,237	–	-1.47%	–
ATRC	Exit	ATRICURE INC	$0	–	-133,229	–	-1.73%	–
AGTC	Exit	APPLIED GENETIC TECHNOL CORP	$0	–	-1,095,139	–	-1.73%	–
BHVN	Exit	BIOHAVEN PHARMACEUTICALS HOLD	$0	–	-84,600	–	-1.79%	–
ARNA	Exit	ARENA PHARMACEUTICALS INC	$0	–	-75,815	–	-1.84%	–
PRQR	Exit	PROQR THERAPEUTICS N V	$0	–	-1,237,400	–	-1.93%	–
CSII	Exit	CARDIOVASCULAR SYSTEMS INC	$0	–	-151,200	–	-1.93%	–
GLPG	Exit	GALAPAGOS NVspon adr	$0	–	-44,375	–	-2.05%	–
IBB	Exit	ISHARES TR NASDAQ BIOTECHetf	$0	–	-55,900	–	-2.46%	–
DRNA	Exit	DICERNA PHARMACEUTICALS INC	$0	–	-454,236	–	-2.66%	–
NBIX	Exit	NEUROCRINE BIOSCIENCES INC	$0	–	-90,208	–	-2.82%	–
DXCM	Exit	DEXCOM INC	$0	–	-21,138	–	-2.83%	–
SAGE	Exit	SAGE THERAPEUTICS INC	$0	–	-158,306	–	-3.14%	–
ARCT	Exit	ARCTURUS THERAPEUTICS HLDG I	$0	–	-229,652	–	-3.20%	–
FATE	Exit	FATE THERAPEUTICS INC	$0	–	-438,460	–	-5.70%	–
BPMC	Exit	BLUEPRINT MEDICINES CORP	$0	–	-233,089	–	-7.02%	–
IMMU	Exit	IMMUNOMEDICS INC	$0	–	-260,905	–	-7.21%	–
STXS	Exit	STEREOTAXIS INC	$0	–	-13,680,554	–	-15.92%	–

Q3 2020

			Value		Shares		↓ Weighting
IMMU	Buy	IMMUNOMEDICS INC	$22,185,000	+149.5%	260,905	+4.0%	7.21%	+181.1%
BPMC	Buy	BLUEPRINT MEDICINES CORP	$21,607,000	+21.4%	233,089	+2.2%	7.02%	+36.8%
FATE	Sell	FATE THERAPEUTICS INC	$17,525,000	+4.1%	438,460	-10.7%	5.70%	+17.2%
ARCT	Buy	ARCTURUS THERAPEUTICS HLDG I	$9,852,000	+41.5%	229,652	+54.1%	3.20%	+59.4%
SAGE	Sell	SAGE THERAPEUTICS INC	$9,676,000	+40.8%	158,306	-4.2%	3.14%	+58.6%
NBIX	Buy	NEUROCRINE BIOSCIENCES INC	$8,674,000	-2.9%	90,208	+23.2%	2.82%	+9.4%
IBB	Buy	ISHARES TR NASDAQ BIOTECHetf	$7,569,000	+0.9%	55,900	+1.8%	2.46%	+13.6%
ARNA	Sell	ARENA PHARMACEUTICALS INC	$5,670,000	-63.3%	75,815	-69.1%	1.84%	-58.6%
BHVN	Sell	BIOHAVEN PHARMACEUTICALS HOLD	$5,500,000	-14.1%	84,600	-3.4%	1.79%	-3.2%
AGTC	Sell	APPLIED GENETIC TECHNOL CORP	$5,322,000	-17.2%	1,095,139	-5.7%	1.73%	-6.8%
ASND	Buy	ASCENDIS PHARMA A Ssponsored adr	$4,512,000	+114.2%	29,237	+105.4%	1.47%	+141.3%
IDYA	New	IDEAYA BIOSCIENCES INC	$4,166,000	–	331,661	–	1.35%	–
CNST	Buy	CONSTELLATION PHARMACEUTICAL	$3,666,000	-28.6%	180,942	+5.8%	1.19%	-19.6%
AERI	Buy	AERIE PHARMACEUTICALS INC	$3,348,000	-18.8%	284,440	+1.8%	1.09%	-8.6%
CARA	Sell	CARA THERAPEUTICS INC	$3,148,000	-50.4%	247,377	-33.3%	1.02%	-44.1%
AFMD	Buy	AFFIMED NV	$3,133,000	-19.7%	924,278	+9.4%	1.02%	-9.6%
MRSN	Sell	MERSANA THERAPEUTICS INC	$2,844,000	-55.0%	152,763	-43.5%	0.92%	-49.3%
ETNB	Buy	89BIO INC	$2,835,000	+594.9%	110,478	+439.5%	0.92%	+681.4%
LQDA	Buy	LIQUIDIA TECHNOLOGIES INC	$2,829,000	-38.9%	575,000	+4.5%	0.92%	-31.1%
OTIC	Buy	OTONOMY INC	$2,791,000	+64.4%	689,100	+46.9%	0.91%	+85.1%
KALV	Sell	KALVISTA PHARMACEUTICALS INC	$2,619,000	-2.7%	208,054	-6.5%	0.85%	+9.5%
TBIO	New	TRANSLATE BIO INC	$2,599,000	–	190,930	–	0.84%	–
ARAY	Buy	ACCURAY INC	$2,578,000	+88.3%	1,074,300	+59.3%	0.84%	+112.2%
BCRX	Buy	BIOCRYST PHARMACEUTICALS INC	$2,573,000	-27.4%	749,051	+0.7%	0.84%	-18.3%
KDMN	Buy	KADMON HOLDINGS INC	$2,209,000	-22.1%	563,564	+1.8%	0.72%	-12.2%
SPPI	New	SPECTRUM PHARMACEUTICALS INC	$2,101,000	–	514,891	–	0.68%	–
MEIP	Buy	MEI PHARMA INC	$2,078,000	+815.4%	666,000	+1110.9%	0.68%	+922.7%
CGEN	Sell	COMPUGEN LTDord	$1,872,000	-63.7%	115,202	-66.4%	0.61%	-59.0%
ISEE	Sell	IVERIC BIO INC	$1,819,000	-0.2%	322,500	-9.8%	0.59%	+12.4%
SNDX	Sell	SYNDAX PHARMACEUTICALS INC	$1,516,000	-71.6%	102,713	-71.5%	0.49%	-68.0%
ALPN	New	ALPINE IMMUNE SCIENCES INC	$1,303,000	–	148,260	–	0.42%	–
	New	AERIE PHARMACEUTICALS INCnote 1.500%10/0	$1,206,000	–	1,500,000	–	0.39%	–
LRMR	Sell	LARIMAR THERAPEUTICS INC	$1,201,000	-26.0%	79,155	-37.3%	0.39%	-16.7%
KURA	Sell	KURA ONCOLOGY INC	$1,196,000	-75.1%	39,019	-86.7%	0.39%	-71.9%
STRO	Buy	SUTRO BIOPHARMA INC	$1,195,000	+44.7%	118,940	+11.7%	0.39%	+63.0%
SPRO	New	SPERO THERAPEUTICS INC	$1,116,000	–	100,000	–	0.36%	–
VRNA	New	VERONA PHARMA PLCsponsored ads	$1,008,000	–	161,507	–	0.33%	–
APLS	Sell	APELLIS PHARMACEUTICALS INC	$907,000	-17.2%	30,054	-10.4%	0.30%	-6.6%
AKBA	Sell	AKEBIA THERAPEUTICS INC	$858,000	-91.7%	341,779	-55.2%	0.28%	-90.7%
ACET	New	ADICET BIO INC	$803,000	–	67,577	–	0.26%	–
AXGT	Sell	AXOVANT SCIENCES LTD	$790,000	-72.1%	171,083	-83.0%	0.26%	-68.6%
ARDX	Sell	ARDELYX INC	$759,000	-40.7%	144,650	-21.7%	0.25%	-33.1%
NXTC	Buy	NEXTCURE INC	$748,000	+74.4%	85,000	+325.0%	0.24%	+96.0%
SCPH	Sell	SCPHARMACEUTICALS INC	$677,000	-8.0%	90,900	-9.1%	0.22%	+3.8%
DMAC	New	DIAMEDICA THERAPEUTICS INC	$664,000	–	156,529	–	0.22%	–
CHMA	New	CHIASMA INC	$659,000	–	153,208	–	0.21%	–
MREO	Buy	MEREO BIOPHARMA GROUP PLCads	$522,000	+122.1%	199,425	+159.7%	0.17%	+150.0%
ZYME	Sell	ZYMEWORKS INC	$463,000	-28.9%	9,950	-44.8%	0.15%	-19.7%
HOOK	Sell	HOOKIPA PHARMA INC	$209,000	-77.6%	22,061	-72.5%	0.07%	-74.7%
CRDF	New	CARDIFF ONCOLOGY INC	$71,000	–	5,000	–	0.02%	–
CTMX	Exit	CYTOMX THERAPEUTICS INC	$0	–	-6,100	–	-0.02%	–
RIGL	Exit	RIGEL PHARMACEUTICALS INC	$0	–	-157,700	–	-0.08%	–
GRTS	Exit	GRITSTONE ONCOLOGY INC	$0	–	-50,000	–	-0.10%	–
PRVB	Exit	PROVENTION BIO INC	$0	–	-25,000	–	-0.10%	–
ALRN	Exit	AILERON THERAPEUTICS INC	$0	–	-450,000	–	-0.15%	–
LPTX	Exit	LEAP THERAPEUTICS INC	$0	–	-275,000	–	-0.17%	–
CBAY	Exit	CYMABAY THERAPEUTICS INC	$0	–	-165,600	–	-0.17%	–
TCRR	Exit	TCR2 THERAPEUTICS INC	$0	–	-46,183	–	-0.20%	–
MORF	Exit	MORPHIC HOLDING INC	$0	–	-30,000	–	-0.23%	–
SYBX	Exit	SYNLOGIC INC	$0	–	-403,597	–	-0.24%	–
CERC	Exit	CERECOR INC	$0	–	-318,000	–	-0.24%	–
SLNO	Exit	SOLENO THERAPEUTICS INC	$0	–	-372,500	–	-0.24%	–
CRBP	Exit	CORBUS PHARMACEUTICALS HLDGS	$0	–	-108,061	–	-0.26%	–
AUTL	Exit	AUTOLUS THERAPEUTICS PLCspon ads	$0	–	-64,235	–	-0.30%	–
GNCA	Exit	GENOCEA BIOSCIENCES INC	$0	–	-524,664	–	-0.35%	–
ZGNX	Exit	ZOGENIX INC	$0	–	-50,749	–	-0.40%	–
TPTX	Exit	TURNING POINT THERAPEUTICS I	$0	–	-23,210	–	-0.43%	–
MRTX	Exit	MIRATI THERAPEUTICS INC	$0	–	-21,893	–	-0.72%	–

Q2 2020

			Value		Shares		↓ Weighting
STXS	New	STEREOTAXIS INC	$61,015,000	–	13,680,554	–	17.61%	–
BPMC	New	BLUEPRINT MEDICINES CORP	$17,791,000	–	228,089	–	5.13%	–
FATE	New	FATE THERAPEUTICS INC	$16,841,000	–	490,861	–	4.86%	–
ARNA	New	ARENA PHARMACEUTICALS INC	$15,432,000	–	245,142	–	4.45%	–
DRNA	New	DICERNA PHARMACEUTICALS INC	$11,538,000	–	454,236	–	3.33%	–
AKBA	New	AKEBIA THERAPEUTICS INC	$10,357,000	–	762,666	–	2.99%	–
NBIX	New	NEUROCRINE BIOSCIENCES INC	$8,931,000	–	73,208	–	2.58%	–
IMMU	New	IMMUNOMEDICS INC	$8,892,000	–	250,905	–	2.57%	–
GLPG	New	GALAPAGOS NVspon adr	$8,755,000	–	44,375	–	2.53%	–
DXCM	New	DEXCOM INC	$8,569,000	–	21,138	–	2.47%	–
PRQR	New	PROQR THERAPEUTICS N V	$7,523,000	–	1,237,400	–	2.17%	–
IBB	New	ISHARES TR NASDAQ BIOTECHetf	$7,504,000	–	54,900	–	2.17%	–
ARCT	New	ARCTURUS THERAPEUTICS HLDG I	$6,965,000	–	149,017	–	2.01%	–
SAGE	New	SAGE THERAPEUTICS INC	$6,873,000	–	165,306	–	1.98%	–
AGTC	New	APPLIED GENETIC TECHNOL CORP	$6,431,000	–	1,160,878	–	1.86%	–
BHVN	New	BIOHAVEN PHARMACEUTICALS HOLD	$6,404,000	–	87,600	–	1.85%	–
CARA	New	CARA THERAPEUTICS INC	$6,345,000	–	371,033	–	1.83%	–
MRSN	New	MERSANA THERAPEUTICS INC	$6,322,000	–	270,163	–	1.82%	–
ATRC	New	ATRICURE INC	$5,989,000	–	133,229	–	1.73%	–
SNDX	New	SYNDAX PHARMACEUTICALS INC	$5,335,000	–	360,000	–	1.54%	–
CGEN	New	COMPUGEN LTDord	$5,153,000	–	343,046	–	1.49%	–
CNST	New	CONSTELLATION PHARMACEUTICAL	$5,137,000	–	170,942	–	1.48%	–
LMNX	New	LUMINEX CORP	$5,013,000	–	154,091	–	1.45%	–
KURA	New	KURA ONCOLOGY INC	$4,796,000	–	294,260	–	1.38%	–
CSII	New	CARDIOVASCULAR SYSTEMS INC	$4,770,000	–	151,200	–	1.38%	–
LQDA	New	LIQUIDIA TECHNOLOGIES INC	$4,631,000	–	550,000	–	1.34%	–
XENE	New	XENON PHARMACEUTICALS INC	$4,346,000	–	346,535	–	1.25%	–
AERI	New	AERIE PHARMACEUTICALS INC	$4,125,000	–	279,440	–	1.19%	–
AFMD	New	AFFIMED NV	$3,900,000	–	845,000	–	1.13%	–
BCRX	New	BIOCRYST PHARMACEUTICALS INC	$3,545,000	–	744,051	–	1.02%	–
ALEC	New	ALECTOR INC	$3,422,000	–	140,000	–	0.99%	–
VKTX	New	VIKING THERAPEUTICS INC	$3,251,000	–	450,900	–	0.94%	–
	New	RADIUS HEALTH INCnote 3.000% 9/0	$2,990,000	–	4,000,000	–	0.86%	–
KDMN	New	KADMON HOLDINGS INC	$2,834,000	–	553,564	–	0.82%	–
AXGT	New	AXOVANT GENE THERAPIES LTD	$2,835,000	–	1,005,391	–	0.82%	–
BEAT	New	BIOTELEMETRY INC	$2,734,000	–	60,500	–	0.79%	–
KALV	New	KALVISTA PHARMACEUTICALS INC	$2,692,000	–	222,452	–	0.78%	–
MRTX	New	MIRATI THERAPEUTICS INC	$2,500,000	–	21,893	–	0.72%	–
ASND	New	ASCENDIS PHARMA A Ssponsored adr	$2,106,000	–	14,237	–	0.61%	–
BLUE	New	BLUEBIRD BIO INC	$1,848,000	–	30,273	–	0.53%	–
ISEE	New	IVERIC BIO INC	$1,823,000	–	357,500	–	0.53%	–
RCUS	New	ARCUS BIOSCIENCES INC	$1,784,000	–	72,100	–	0.52%	–
OTIC	New	OTONOMY INC	$1,698,000	–	469,135	–	0.49%	–
LRMR	New	LARIMAR THERAPEUTICS INC	$1,622,000	–	126,261	–	0.47%	–
TPTX	New	TURNING POINT THERAPEUTICS I	$1,499,000	–	23,210	–	0.43%	–
PHAS	New	PHASEBIO PHARMACEUTICALS INC	$1,474,000	–	320,542	–	0.42%	–
HARP	New	HARPOON THERAPEUTICS INC	$1,413,000	–	85,119	–	0.41%	–
ZGNX	New	ZOGENIX INC	$1,371,000	–	50,749	–	0.40%	–
ARAY	New	ACCURAY INC	$1,369,000	–	674,300	–	0.40%	–
JNJ	New	JOHNSON AND JOHNSON	$1,322,000	–	9,400	–	0.38%	–
ARDX	New	ARDELYX INC	$1,279,000	–	184,850	–	0.37%	–
GNCA	New	GENOCEA BIOSCIENCES INC	$1,207,000	–	524,664	–	0.35%	–
PRVL	New	PREVAIL THERAPEUTICS INC	$1,118,000	–	75,000	–	0.32%	–
APLS	New	APELLIS PHARMACEUTICALS INC	$1,096,000	–	33,554	–	0.32%	–
KRTX	New	KARUNA THERAPEUTICS INC	$1,029,000	–	9,231	–	0.30%	–
AUTL	New	AUTOLUS THERAPEUTICS PLCspon ads	$1,030,000	–	64,235	–	0.30%	–
STIM	New	NEURONETICS INC	$957,000	–	495,772	–	0.28%	–
NTUS	New	NATUS MEDICAL INC	$936,000	–	42,900	–	0.27%	–
HOOK	New	HOOKIPA PHARMA INC	$931,000	–	80,118	–	0.27%	–
CRBP	New	CORBUS PHARMACEUTICALS HLDGS	$907,000	–	108,061	–	0.26%	–
ASMB	New	ASSEMBLY BIOSCIENCES INC	$830,000	–	35,573	–	0.24%	–
CERC	New	CERECOR INC	$827,000	–	318,000	–	0.24%	–
SLNO	New	SOLENO THERAPEUTICS INC	$827,000	–	372,500	–	0.24%	–
STRO	New	SUTRO BIOPHARMA INC	$826,000	–	106,444	–	0.24%	–
SYBX	New	SYNLOGIC INC	$819,000	–	403,597	–	0.24%	–
MORF	New	MORPHIC HOLDING INC	$812,000	–	30,000	–	0.23%	–
MDGL	New	MADRIGAL PHARMACEUTICALS INC	$747,000	–	6,600	–	0.22%	–
SCPH	New	SCPHARMACEUTICALS INC	$736,000	–	100,000	–	0.21%	–
TCRR	New	TCR2 THERAPEUTICS INC	$709,000	–	46,183	–	0.20%	–
MASI	New	MASIMO CORPORATION	$684,000	–	3,000	–	0.20%	–
ZYME	New	ZYMEWORKS INC	$651,000	–	18,039	–	0.19%	–
GMDA	New	GAMIDA CELL LTD	$640,000	–	140,000	–	0.18%	–
CBAY	New	CYMABAY THERAPEUTICS INC	$578,000	–	165,600	–	0.17%	–
LPTX	New	LEAP THERAPEUTICS INC	$575,000	–	275,000	–	0.17%	–
INGN	New	INOGEN INC	$533,000	–	15,000	–	0.15%	–
ALRN	New	AILERON THERAPEUTICS INC	$531,000	–	450,000	–	0.15%	–
NXTC	New	NEXTCURE INC	$429,000	–	20,000	–	0.12%	–
ETNB	New	89BIO INC	$408,000	–	20,478	–	0.12%	–
PRVB	New	PROVENTION BIO INC	$353,000	–	25,000	–	0.10%	–
GRTS	New	GRITSTONE ONCOLOGY INC	$332,000	–	50,000	–	0.10%	–
RDUS	New	RADIUS HEALTH INC	$300,000	–	22,000	–	0.09%	–
RIGL	New	RIGEL PHARMACEUTICALS INC	$289,000	–	157,700	–	0.08%	–
MREO	New	MEREO BIOPHARMA GROUP PLCads	$235,000	–	76,800	–	0.07%	–
MEIP	New	MEI PHARMA INC	$227,000	–	55,000	–	0.07%	–
ASLN	New	ASLAN PHARMACEUTICALS LTDads	$172,000	–	86,082	–	0.05%	–
LCTX	New	LINEAGE CELL THERAPEUTICS IN	$83,000	–	95,000	–	0.02%	–
CTMX	New	CYTOMX THERAPEUTICS INC	$51,000	–	6,100	–	0.02%	–

Q4 2019

			Value		Shares		↓ Weighting
ORMP	Exit	ORAMED PHARMACEUTICALS INC	$0	–	-16,000	–	-0.02%	–
ALRN	Exit	AILERON THERAPEUTICS INC	$0	–	-99,502	–	-0.02%	–
ADXS	Exit	ADVAXIS INC	$0	–	-350,000	–	-0.04%	–
LCTX	Exit	LINEAGE CELL THERAPEUTICS IN	$0	–	-95,000	–	-0.04%	–
EVLO	Exit	EVELO BIOSCIENCES INC	$0	–	-20,000	–	-0.05%	–
KRTX	Exit	KARUNA THERAPEUTICS INC	$0	–	-11,192	–	-0.07%	–
CDTX	Exit	CIDARA THERAPEUTICS INC	$0	–	-99,993	–	-0.08%	–
BLCM	Exit	BELLICUM PHARMACEUTICALS INC	$0	–	-200,000	–	-0.08%	–
ZFGN	Exit	ZAFGEN INC	$0	–	-305,500	–	-0.08%	–
ALDX	Exit	ALDEYRA THERAPEUTICS INC	$0	–	-50,000	–	-0.10%	–
KALV	Exit	KALVISTA PHARMACEUTICALS INC	$0	–	-24,725	–	-0.11%	–
RIGL	Exit	RIGEL PHARMACEUTICALS INC	$0	–	-157,700	–	-0.11%	–
URGN	Exit	UROGEN PHARMA LTD	$0	–	-15,000	–	-0.13%	–
STRO	Exit	SUTRO BIOPHARMA INC	$0	–	-40,000	–	-0.14%	–
	Exit	DEXCOM INCnote 0.750% 5/1	$0	–	-250,000	–	-0.15%	–
SPRO	Exit	SPERO THERAPEUTICS INC	$0	–	-39,395	–	-0.16%	–
GRTS	Exit	GRITSTONE ONCOLOGY INC	$0	–	-50,000	–	-0.16%	–
MASI	Exit	MASIMO CORPORATION	$0	–	-3,000	–	-0.17%	–
ASMB	Exit	ASSEMBLY BIOSCIENCES INC	$0	–	-50,573	–	-0.19%	–
INSM	Exit	INSMED INC	$0	–	-30,000	–	-0.20%	–
OBSV	Exit	OBSEVA SA	$0	–	-64,231	–	-0.20%	–
RDUS	Exit	RADIUS HEALTH INC	$0	–	-22,000	–	-0.21%	–
MDGL	Exit	MADRIGAL PHARMACEUTICALS INC	$0	–	-6,600	–	-0.21%	–
SNSS	Exit	SUNESIS PHARMACEUTICALS INC	$0	–	-920,995	–	-0.25%	–
DERM	Exit	DERMIRA INC	$0	–	-104,000	–	-0.25%	–
CTMX	Exit	CYTOMX THERAPEUTICS INC	$0	–	-100,000	–	-0.28%	–
MRSN	Exit	MERSANA THERAPEUTICS INC	$0	–	-501,736	–	-0.30%	–
STIM	Exit	NEURONETICS INC	$0	–	-106,247	–	-0.33%	–
BTAI	Exit	BIOXCEL THERAPEUTICS INC	$0	–	-127,500	–	-0.34%	–
PRVL	Exit	PREVAIL THERAPEUTICS INC	$0	–	-75,000	–	-0.35%	–
FOMX	Exit	FOAMIX PHARMACEUTICALS LTD	$0	–	-305,500	–	-0.35%	–
SYBX	Exit	SYNLOGIC INC	$0	–	-432,830	–	-0.37%	–
INGN	Exit	INOGEN INC	$0	–	-23,000	–	-0.41%	–
GMDA	Exit	GAMIDA CELL LTD	$0	–	-272,909	–	-0.44%	–
JNJ	Exit	JOHNSON AND JOHNSON	$0	–	-9,400	–	-0.46%	–
AUTL	Exit	AUTOLUS THERAPEUTICS PLCspon ads	$0	–	-100,000	–	-0.47%	–
EPZM	Exit	EPIZYME INC	$0	–	-121,986	–	-0.47%	–
SCYX	Exit	SCYNEXIS INC	$0	–	-1,272,927	–	-0.51%	–
NTUS	Exit	NATUS MEDICAL INC	$0	–	-42,900	–	-0.51%	–
BCRX	Exit	BIOCRYST PHARMACEUTICALS INC	$0	–	-483,388	–	-0.52%	–
VKTX	Exit	VIKING THERAPEUTICS INC	$0	–	-209,200	–	-0.54%	–
CRBP	Exit	CORBUS PHARMACEUTICALS HLDGS	$0	–	-297,300	–	-0.54%	–
AGTC	Exit	APPLIED GENETIC TECHNOL CORP	$0	–	-359,190	–	-0.56%	–
PHAS	Exit	PHASEBIO PHARMACEUTICALS INC	$0	–	-360,542	–	-0.56%	–
PRQR	Exit	PROQR THERAPEUTICS N V	$0	–	-261,521	–	-0.57%	–
KURA	Exit	KURA ONCOLOGY INC	$0	–	-103,658	–	-0.59%	–
GNCA	Exit	GENOCEA BIOSCIENCES INC	$0	–	-542,564	–	-0.59%	–
ACHN	Exit	ACHILLION PHARMACEUTICALS	$0	–	-438,884	–	-0.59%	–
ELOX	Exit	ELOXX PHARMACEUTICALS INC	$0	–	-375,000	–	-0.64%	–
DRNA	Exit	DICERNA PHARMACEUTICALS INC	$0	–	-118,314	–	-0.64%	–
TPTX	Exit	TURNING POINT THERAPEUTICS I	$0	–	-47,308	–	-0.67%	–
ARCT	Exit	ARCTURUS THERAPEUTICS HLDG I	$0	–	-173,914	–	-0.67%	–
CBAY	Exit	CYMABAY THERAPEUTICS INC	$0	–	-349,996	–	-0.67%	–
NVRO	Exit	NEVRO CORP	$0	–	-21,210	–	-0.69%	–
BEAT	Exit	BIOTELEMETRY INC	$0	–	-45,300	–	-0.69%	–
ARAY	Exit	ACCURAY INC	$0	–	-674,300	–	-0.70%	–
ALEC	Exit	ALECTOR INC	$0	–	-145,000	–	-0.79%	–
CSII	Exit	CARDIOVASCULAR SYSTEMS INC	$0	–	-46,200	–	-0.83%	–
KDMN	Exit	KADMON HOLDINGS INC	$0	–	-886,177	–	-0.84%	–
BLUE	Exit	BLUEBIRD BIO INC	$0	–	-25,500	–	-0.88%	–
ARGX	Exit	ARGENX SEsponsored adr	$0	–	-21,969	–	-0.94%	–
MGNX	Exit	MACROGENICS INC	$0	–	-200,000	–	-0.96%	–
ARDX	Exit	ARDELYX INC	$0	–	-580,524	–	-1.03%	–
XENE	Exit	XENON PHARMACEUTICALS INC	$0	–	-330,667	–	-1.12%	–
AKBA	Exit	AKEBIA THERAPEUTICS INC	$0	–	-828,038	–	-1.22%	–
TBIO	Exit	TRANSLATE BIO INC	$0	–	-364,229	–	-1.36%	–
	Exit	RADIUS HEALTH INCnote 3.000% 9/0	$0	–	-4,000,000	–	-1.38%	–
ARQL	Exit	ARQULE INC	$0	–	-530,262	–	-1.43%	–
MNLO	Exit	MENLO THERAPEUTICS INC	$0	–	-856,936	–	-1.44%	–
BHVN	Exit	BIOHAVEN PHARMACEUTICALS HOLD	$0	–	-95,000	–	-1.49%	–
WVE	Exit	WAVE LIFE SCIENCES LTD	$0	–	-197,554	–	-1.52%	–
APLS	Exit	APELLIS PHARMACEUTICALS INC	$0	–	-169,800	–	-1.54%	–
LMNX	Exit	LUMINEX CORP	$0	–	-204,091	–	-1.58%	–
ARNA	Exit	ARENA PHARMACEUTICALS INC	$0	–	-93,942	–	-1.62%	–
CYTK	Exit	CYTOKINETICS INC	$0	–	-418,727	–	-1.79%	–
DXCM	Exit	DEXCOM INC	$0	–	-36,338	–	-2.04%	–
AERI	Exit	AERIE PHARMACEUTICALS INC	$0	–	-287,748	–	-2.08%	–
ZGNX	Exit	ZOGENIX INC	$0	–	-142,764	–	-2.15%	–
NBIX	Exit	NEUROCRINE BIOSCIENCES INC	$0	–	-64,508	–	-2.19%	–
ASND	Exit	ASCENDIS PHARMA A Ssponsored adr	$0	–	-60,480	–	-2.19%	–
IBB	Exit	ISHARES TR NASDAQ BIOTECHetf	$0	–	-64,900	–	-2.43%	–
CARA	Exit	CARA THERAPEUTICS INC	$0	–	-378,924	–	-2.60%	–
FATE	Exit	FATE THERAPEUTICS INC	$0	–	-470,000	–	-2.74%	–
ATRC	Exit	ATRICURE INC	$0	–	-318,729	–	-2.99%	–
GLPG	Exit	GALAPAGOS NVspon adr	$0	–	-52,509	–	-3.02%	–
BPMC	Exit	BLUEPRINT MEDICINES CORP	$0	–	-123,218	–	-3.40%	–
ALDR	Exit	ALDER BIOPHARMACEUTICALS INC	$0	–	-636,013	–	-4.51%	–
SAGE	Exit	SAGE THERAPEUTICS INC	$0	–	-124,806	–	-6.58%	–
STXS	Exit	STEREOTAXIS INC	$0	–	-13,680,554	–	-18.06%	–

Q3 2019

			Value		Shares		↓ Weighting
SAGE	Buy	SAGE THERAPEUTICS INC	$17,509,000	-22.8%	124,806	+0.8%	6.58%	-22.7%
FATE	Buy	FATE THERAPEUTICS INC	$7,299,000	+498.8%	470,000	+682.9%	2.74%	+499.3%
CARA	Buy	CARA THERAPEUTICS INC	$6,927,000	+57.1%	378,924	+84.8%	2.60%	+57.2%
IBB	Buy	ISHARES TR NASDAQ BIOTECHetf	$6,458,000	-3.6%	64,900	+5.7%	2.43%	-3.5%
ASND	Buy	ASCENDIS PHARMA A Ssponsored adr	$5,825,000	-14.8%	60,480	+1.9%	2.19%	-14.7%
NBIX	Sell	NEUROCRINE BIOSCIENCES INC	$5,813,000	+6.6%	64,508	-0.2%	2.19%	+6.6%
ZGNX	Buy	ZOGENIX INC	$5,716,000	-15.0%	142,764	+1.4%	2.15%	-15.0%
AERI	Buy	AERIE PHARMACEUTICALS INC	$5,531,000	-8.9%	287,748	+40.1%	2.08%	-8.9%
CYTK	Sell	CYTOKINETICS INC	$4,765,000	-11.2%	418,727	-12.3%	1.79%	-11.2%
LMNX	Buy	LUMINEX CORP	$4,214,000	+5.2%	204,091	+5.2%	1.58%	+5.2%
APLS	New	APELLIS PHARMACEUTICALS INC	$4,090,000	–	169,800	–	1.54%	–
WVE	Sell	WAVE LIFE SCIENCES LTD	$4,056,000	-28.5%	197,554	-9.2%	1.52%	-28.5%
MNLO	Buy	MENLO THERAPEUTICS INC	$3,839,000	+6.8%	856,936	+42.8%	1.44%	+6.9%
ARQL	Buy	ARQULE INC	$3,802,000	-30.6%	530,262	+6.5%	1.43%	-30.6%
TBIO	Buy	TRANSLATE BIO INC	$3,610,000	+60.3%	364,229	+104.3%	1.36%	+60.3%
AKBA	Sell	AKEBIA THERAPEUTICS INC	$3,246,000	-19.3%	828,038	-0.3%	1.22%	-19.2%
ARDX	Sell	ARDELYX INC	$2,728,000	+48.7%	580,524	-14.8%	1.03%	+48.9%
MGNX	Buy	MACROGENICS INC	$2,552,000	+200.6%	200,000	+300.0%	0.96%	+200.9%
ARGX	Sell	ARGENX SEsponsored adr	$2,504,000	-44.3%	21,969	-30.8%	0.94%	-44.3%
CSII	Sell	CARDIOVASCULAR SYSTEMS INC	$2,195,000	-0.1%	46,200	-9.8%	0.83%	0.0%
ALEC	Buy	ALECTOR INC	$2,091,000	+375.2%	145,000	+525.9%	0.79%	+376.4%
ARAY	Buy	ACCURAY INC	$1,868,000	-7.9%	674,300	+28.6%	0.70%	-7.9%
NVRO	Sell	NEVRO CORP	$1,823,000	+7.3%	21,210	-19.1%	0.69%	+7.4%
ARCT	Buy	ARCTURUS THERAPEUTICS HLDG I	$1,786,000	+7665.2%	173,914	+7146.4%	0.67%	+7366.7%
TPTX	New	TURNING POINT THERAPEUTICS I	$1,779,000	–	47,308	–	0.67%	–
ACHN	Sell	ACHILLION PHARMACEUTICALS	$1,580,000	-2.5%	438,884	-27.4%	0.59%	-2.5%
GNCA	Sell	GENOCEA BIOSCIENCES INC	$1,573,000	-45.4%	542,564	-26.1%	0.59%	-45.3%
KURA	Buy	KURA ONCOLOGY INC	$1,572,000	+69.0%	103,658	+119.4%	0.59%	+68.9%
PHAS	Buy	PHASEBIO PHARMACEUTICALS INC	$1,503,000	-42.7%	360,542	+80.3%	0.56%	-42.7%
BCRX	Buy	BIOCRYST PHARMACEUTICALS INC	$1,385,000	-11.0%	483,388	+17.6%	0.52%	-10.9%
EPZM	Sell	EPIZYME INC	$1,258,000	-42.2%	121,986	-29.7%	0.47%	-42.2%
GMDA	Sell	GAMIDA CELL LTD	$1,182,000	-15.4%	272,909	-0.8%	0.44%	-15.2%
SYBX	New	SYNLOGIC INC	$991,000	–	432,830	–	0.37%	–
FOMX	Sell	FOAMIX PHARMACEUTICALS LTD	$929,000	-51.7%	305,500	-62.2%	0.35%	-51.7%
BTAI	New	BIOXCEL THERAPEUTICS INC	$898,000	–	127,500	–	0.34%	–
STIM	New	NEURONETICS INC	$883,000	–	106,247	–	0.33%	–
MRSN	Buy	MERSANA THERAPEUTICS INC	$793,000	-28.9%	501,736	+82.3%	0.30%	-28.9%
CTMX	New	CYTOMX THERAPEUTICS INC	$738,000	–	100,000	–	0.28%	–
SNSS	New	SUNESIS PHARMACEUTICALS INC	$663,000	–	920,995	–	0.25%	–
OBSV	Buy	OBSEVA SA	$535,000	-5.1%	64,231	+28.9%	0.20%	-5.2%
SPRO	Sell	SPERO THERAPEUTICS INC	$418,000	-48.1%	39,395	-43.7%	0.16%	-48.2%
STRO	Buy	SUTRO BIOPHARMA INC	$364,000	+1.7%	40,000	+27.0%	0.14%	+1.5%
RIGL	Buy	RIGEL PHARMACEUTICALS INC	$295,000	-17.8%	157,700	+14.6%	0.11%	-17.8%
ZFGN	Buy	ZAFGEN INC	$226,000	-33.5%	305,500	+7.0%	0.08%	-33.6%
BLCM	Buy	BELLICUM PHARMACEUTICALS INC	$210,000	+311.8%	200,000	+566.7%	0.08%	+315.8%
CDTX	Sell	CIDARA THERAPEUTICS INC	$199,000	-44.3%	99,993	-53.0%	0.08%	-44.0%
KRTX	Buy	KARUNA THERAPEUTICS INC	$183,000	-8.5%	11,192	+11.9%	0.07%	-8.0%
EVLO	New	EVELO BIOSCIENCES INC	$122,000	–	20,000	–	0.05%	–
LCTX	New	LINEAGE CELL THERAPEUTICS IN	$93,000	–	95,000	–	0.04%	–
ADXS	New	ADVAXIS INC	$93,000	–	350,000	–	0.04%	–
NGM	Exit	NGM BIOPHARMACEUTICALS INC	$0	–	-6,265	–	-0.04%	–
BTX	Exit	BIOTIME INC	$0	–	-95,000	–	-0.04%	–
	Exit	ALDER BIOPHARMACEUTICALS INCnote 2.500% 2/0	$0	–	-250,000	–	-0.09%	–
SLGL	Exit	SOL GEL TECHNOLOGIES LTD	$0	–	-35,000	–	-0.12%	–
MORF	Exit	MORPHIC HOLDING INC	$0	–	-60,000	–	-0.45%	–
NXTC	Exit	NEXTCURE INC	$0	–	-96,100	–	-0.54%	–
	Exit	INTEC PHARMA LTD JERUSALEM	$0	–	-415,989	–	-0.68%	–
CRTX	Exit	CORTEXYME INC	$0	–	-65,400	–	-1.04%	–

Q2 2019

			Value		Shares		↓ Weighting
STXS	New	STEREOTAXIS INC	$39,673,000	–	13,680,554	–	14.91%	–
SAGE	New	SAGE THERAPEUTICS INC	$22,668,000	–	123,806	–	8.52%	–
BPMC	New	BLUEPRINT MEDICINES CORP	$11,623,000	–	123,218	–	4.37%	–
ATRC	New	ATRICURE INC	$9,511,000	–	318,729	–	3.58%	–
ALDR	New	ALDER BIOPHARMACEUTICALS INC	$7,486,000	–	636,013	–	2.81%	–
ASND	New	ASCENDIS PHARMA A Ssponsored adr	$6,838,000	–	59,380	–	2.57%	–
GLPG	New	GALAPAGOS NVspon adr	$6,770,000	–	52,509	–	2.54%	–
ZGNX	New	ZOGENIX INC	$6,726,000	–	140,764	–	2.53%	–
IBB	New	ISHARES TR NASDAQ BIOTECHetf	$6,699,000	–	61,400	–	2.52%	–
AERI	New	AERIE PHARMACEUTICALS INC	$6,071,000	–	205,440	–	2.28%	–
WVE	New	WAVE LIFE SCIENCES LTD	$5,676,000	–	217,554	–	2.13%	–
ARNA	New	ARENA PHARMACEUTICALS INC	$5,508,000	–	93,942	–	2.07%	–
ARQL	New	ARQULE INC	$5,480,000	–	497,762	–	2.06%	–
NBIX	New	NEUROCRINE BIOSCIENCES INC	$5,455,000	–	64,608	–	2.05%	–
DXCM	New	DEXCOM INC	$5,445,000	–	36,338	–	2.05%	–
CYTK	New	CYTOKINETICS INC	$5,368,000	–	477,196	–	2.02%	–
ARGX	New	ARGENX SEsponsored adr	$4,495,000	–	31,750	–	1.69%	–
CARA	New	CARA THERAPEUTICS INC	$4,408,000	–	205,011	–	1.66%	–
BHVN	New	BIOHAVEN PHARMACEUTICALS HOLD	$4,160,000	–	95,000	–	1.56%	–
AKBA	New	AKEBIA THERAPEUTICS INC	$4,020,000	–	830,538	–	1.51%	–
LMNX	New	LUMINEX CORP	$4,006,000	–	194,091	–	1.51%	–
ELOX	New	ELOXX PHARMACEUTICALS INC	$3,739,000	–	375,000	–	1.40%	–
	New	RADIUS HEALTH INCnote 3.000% 9/0	$3,624,000	–	4,000,000	–	1.36%	–
MNLO	New	MENLO THERAPEUTICS INC	$3,594,000	–	600,030	–	1.35%	–
XENE	New	XENON PHARMACEUTICALS INC	$3,260,000	–	330,667	–	1.22%	–
BLUE	New	BLUEBIRD BIO INC	$3,244,000	–	25,500	–	1.22%	–
GNCA	New	GENOCEA BIOSCIENCES INC	$2,879,000	–	734,422	–	1.08%	–
CRTX	New	CORTEXYME INC	$2,780,000	–	65,400	–	1.04%	–
PHAS	New	PHASEBIO PHARMACEUTICALS INC	$2,624,000	–	200,013	–	0.99%	–
CBAY	New	CYMABAY THERAPEUTICS INC	$2,506,000	–	349,996	–	0.94%	–
PRQR	New	PROQR THERAPEUTICS N V	$2,380,000	–	261,521	–	0.90%	–
TBIO	New	TRANSLATE BIO INC	$2,252,000	–	178,306	–	0.85%	–
CSII	New	CARDIOVASCULAR SYSTEMS INC	$2,198,000	–	51,200	–	0.83%	–
BEAT	New	BIOTELEMETRY INC	$2,181,000	–	45,300	–	0.82%	–
EPZM	New	EPIZYME INC	$2,178,000	–	173,536	–	0.82%	–
CRBP	New	CORBUS PHARMACEUTICALS HLDGS	$2,060,000	–	297,300	–	0.77%	–
ARAY	New	ACCURAY INC	$2,029,000	–	524,300	–	0.76%	–
FOMX	New	FOAMIX PHARMACEUTICALS LTD	$1,923,000	–	808,000	–	0.72%	–
DRNA	New	DICERNA PHARMACEUTICALS INC	$1,863,000	–	118,314	–	0.70%	–
ARDX	New	ARDELYX INC	$1,834,000	–	681,759	–	0.69%	–
KDMN	New	KADMON HOLDINGS INC	$1,826,000	–	886,177	–	0.69%	–
	New	INTEC PHARMA LTD JERUSALEM	$1,805,000	–	415,989	–	0.68%	–
VKTX	New	VIKING THERAPEUTICS INC	$1,736,000	–	209,200	–	0.65%	–
NVRO	New	NEVRO CORP	$1,699,000	–	26,210	–	0.64%	–
SCYX	New	SCYNEXIS INC	$1,668,000	–	1,272,927	–	0.63%	–
ACHN	New	ACHILLION PHARMACEUTICALS	$1,621,000	–	604,884	–	0.61%	–
AUTL	New	AUTOLUS THERAPEUTICS PLCspon ads	$1,610,000	–	100,000	–	0.60%	–
BCRX	New	BIOCRYST PHARMACEUTICALS INC	$1,557,000	–	410,888	–	0.58%	–
INGN	New	INOGEN INC	$1,535,000	–	23,000	–	0.58%	–
NXTC	New	NEXTCURE INC	$1,440,000	–	96,100	–	0.54%	–
GMDA	New	GAMIDA CELL LTD	$1,397,000	–	275,000	–	0.52%	–
AGTC	New	APPLIED GENETIC TECHNOL CORP	$1,361,000	–	359,190	–	0.51%	–
JNJ	New	JOHNSON AND JOHNSON	$1,309,000	–	9,400	–	0.49%	–
FATE	New	FATE THERAPEUTICS INC	$1,219,000	–	60,031	–	0.46%	–
MORF	New	MORPHIC HOLDING INC	$1,189,000	–	60,000	–	0.45%	–
MRSN	New	MERSANA THERAPEUTICS INC	$1,115,000	–	275,236	–	0.42%	–
NTUS	New	NATUS MEDICAL INC	$1,102,000	–	42,900	–	0.41%	–
DERM	New	DERMIRA INC	$994,000	–	104,000	–	0.37%	–
PRVL	New	PREVAIL THERAPEUTICS INC	$990,000	–	75,000	–	0.37%	–
KURA	New	KURA ONCOLOGY INC	$930,000	–	47,242	–	0.35%	–
MGNX	New	MACROGENICS INC	$849,000	–	50,000	–	0.32%	–
SPRO	New	SPERO THERAPEUTICS INC	$806,000	–	70,000	–	0.30%	–
INSM	New	INSMED INC	$768,000	–	30,000	–	0.29%	–
MDGL	New	MADRIGAL PHARMACEUTICALS INC	$692,000	–	6,600	–	0.26%	–
ASMB	New	ASSEMBLY BIOSCIENCES INC	$682,000	–	50,573	–	0.26%	–
OBSV	New	OBSEVA SA	$564,000	–	49,848	–	0.21%	–
GRTS	New	GRITSTONE ONCOLOGY INC	$557,000	–	50,000	–	0.21%	–
KALV	New	KALVISTA PHARMACEUTICALS INC	$548,000	–	24,725	–	0.21%	–
URGN	New	UROGEN PHARMA LTD	$539,000	–	15,000	–	0.20%	–
RDUS	New	RADIUS HEALTH INC	$536,000	–	22,000	–	0.20%	–
MASI	New	MASIMO CORPORATION	$446,000	–	3,000	–	0.17%	–
ALEC	New	ALECTOR INC	$440,000	–	23,166	–	0.16%	–
	New	DEXCOM INCnote 0.750% 5/1	$399,000	–	250,000	–	0.15%	–
RIGL	New	RIGEL PHARMACEUTICALS INC	$359,000	–	137,600	–	0.14%	–
STRO	New	SUTRO BIOPHARMA INC	$358,000	–	31,494	–	0.14%	–
CDTX	New	CIDARA THERAPEUTICS INC	$357,000	–	212,766	–	0.13%	–
ZFGN	New	ZAFGEN INC	$340,000	–	285,500	–	0.13%	–
SLGL	New	SOL GEL TECHNOLOGIES LTD	$319,000	–	35,000	–	0.12%	–
ALDX	New	ALDEYRA THERAPEUTICS INC	$300,000	–	50,000	–	0.11%	–
	New	ALDER BIOPHARMACEUTICALS INCnote 2.500% 2/0	$232,000	–	250,000	–	0.09%	–
KRTX	New	KARUNA THERAPEUTICS INC	$200,000	–	10,000	–	0.08%	–
BTX	New	BIOTIME INC	$105,000	–	95,000	–	0.04%	–
NGM	New	NGM BIOPHARMACEUTICALS INC	$92,000	–	6,265	–	0.04%	–
ALRN	New	AILERON THERAPEUTICS INC	$72,000	–	99,502	–	0.03%	–
ORMP	New	ORAMED PHARMACEUTICALS INC	$57,000	–	16,000	–	0.02%	–
BLCM	New	BELLICUM PHARMACEUTICALS INC	$51,000	–	30,000	–	0.02%	–
ARCT	New	ARCTURUS THERAPEUTICS HLDG I	$23,000	–	2,400	–	0.01%	–

Q4 2018

			Value		Shares		↓ Weighting
DERM	Exit	DERMIRA INC	$0	–	-5,000	–	-0.02%	–
NEOS	Exit	NEOS THERAPEUTICS INC	$0	–	-27,500	–	-0.06%	–
BLCM	Exit	BELLICUM PHARMACEUTICALS INC	$0	–	-30,000	–	-0.08%	–
KDMN	Exit	KADMON HOLDINGS INC	$0	–	-63,000	–	-0.09%	–
BTX	Exit	BIOTIME INC	$0	–	-100,000	–	-0.10%	–
SLGL	Exit	SOL GEL TECHNOLOGIES LTD	$0	–	-35,000	–	-0.11%	–
	Exit	ALDER BIOPHARMACEUTICALS INCnote 2.500% 2/0	$0	–	-250,000	–	-0.11%	–
NERV	Exit	MINERVA NEUROSCIENCES INC	$0	–	-26,907	–	-0.14%	–
RDUS	Exit	RADIUS HEALTH INC	$0	–	-20,500	–	-0.15%	–
MASI	Exit	MASIMO CORPORATION	$0	–	-3,000	–	-0.15%	–
	Exit	DEXCOM INCnote 0.750% 5/1	$0	–	-250,000	–	-0.16%	–
KALV	Exit	KALVISTA PHARMACEUTICALS INC	$0	–	-17,725	–	-0.16%	–
ASMB	Exit	ASSEMBLY BIOSCIENCES INC	$0	–	-10,673	–	-0.16%	–
STRO	Exit	SUTRO BIOPHARMA INC	$0	–	-27,494	–	-0.17%	–
APTX	Exit	APTINYX INC	$0	–	-14,500	–	-0.17%	–
NTGN	Exit	NEON THERAPEUICS INC	$0	–	-50,000	–	-0.18%	–
RIGL	Exit	RIGEL PHARMACEUTICALS INC	$0	–	-137,600	–	-0.18%	–
CYTK	Exit	CYTOKINETICS INC	$0	–	-62,690	–	-0.25%	–
URGN	Exit	UROGEN PHARMA LTD	$0	–	-15,000	–	-0.29%	–
SPRO	Exit	SPERO THERAPEUTICS INC	$0	–	-70,000	–	-0.30%	–
SNSS	Exit	SUNESIS PHARMACEUTICALS INC	$0	–	-373,702	–	-0.31%	–
OBSV	Exit	OBSEVA SA	$0	–	-43,338	–	-0.32%	–
CDTX	Exit	CIDARA THERAPEUTICS INC	$0	–	-212,766	–	-0.38%	–
ZFGN	Exit	ZAFGEN INC	$0	–	-85,842	–	-0.41%	–
LPTX	Exit	LEAP THERPEUTICS INC	$0	–	-140,643	–	-0.45%	–
BHVN	Exit	BIOHAVEN PHARMACEUTICALS HOLD	$0	–	-30,000	–	-0.46%	–
IMDZ	Exit	IMMUNE DESIGN CORP	$0	–	-328,500	–	-0.46%	–
JNJ	Exit	JOHNSON AND JOHNSON	$0	–	-9,400	–	-0.53%	–
NVAX	Exit	NOVAVAX INC	$0	–	-700,000	–	-0.54%	–
NTUS	Exit	NATUS MEDICAL INC	$0	–	-37,900	–	-0.56%	–
INCY	Exit	INCYTE CORP	$0	–	-21,500	–	-0.61%	–
TBIO	Exit	TRANSLATE BIO INC	$0	–	-151,739	–	-0.62%	–
SCYX	Exit	SCYNEXIS INC	$0	–	-1,272,927	–	-0.63%	–
ADXS	Exit	ADVAXIS INC	$0	–	-1,666,666	–	-0.64%	–
MGNX	Exit	MACROGENICS INC	$0	–	-78,305	–	-0.69%	–
DRNA	Exit	DICERNA PHARMACEUTICALS INC	$0	–	-118,500	–	-0.74%	–
	Exit	INSULET CORPnote 1.375%	$0	–	-1,500,000	–	-0.78%	–
ARDX	Exit	ARDELYX INC	$0	–	-472,859	–	-0.84%	–
CSII	Exit	CARDIOVASCULAR SYSTEMS INC	$0	–	-56,200	–	-0.90%	–
VBIV	Exit	VBI VACCINES INC	$0	–	-934,691	–	-0.93%	–
WVE	Exit	WAVE LIFE SCIENCES LTD	$0	–	-47,900	–	-0.98%	–
ARQL	Exit	ARQULE INC	$0	–	-447,664	–	-1.04%	–
AGTC	Exit	APPLIED GENETIC TECHNOL CORP	$0	–	-359,860	–	-1.08%	–
CARA	Exit	CARA THERAPEUTICS INC	$0	–	-112,811	–	-1.11%	–
BLUE	Exit	BLUEBIRD BIO INC	$0	–	-20,500	–	-1.23%	–
BEAT	Exit	BIOTELEMETRY INC	$0	–	-46,800	–	-1.24%	–
	Exit	INTEC PHARMA LTD JERUSALEM	$0	–	-537,000	–	-1.25%	–
MNLO	Exit	MENLO THERAPEUTICS INC	$0	–	-312,000	–	-1.26%	–
	Exit	RADIUS HEALTH INCnote 3.000% 9/0	$0	–	-4,000,000	–	-1.26%	–
ACHN	Exit	ACHILLION PHARMACEUTICALS	$0	–	-847,636	–	-1.28%	–
XENE	Exit	XENON PHARMACEUTICALS INC	$0	–	-237,683	–	-1.29%	–
IBB	Exit	ISHARES TR NASDAQ BIOTECHetf	$0	–	-26,100	–	-1.31%	–
CBAY	Exit	CYMABAY THERAPEUTICS INC	$0	–	-294,511	–	-1.34%	–
IMMU	Exit	IMMUNOMEDICS INC	$0	–	-178,000	–	-1.52%	–
LMNX	Exit	LUMINEX CORP	$0	–	-138,391	–	-1.72%	–
KURA	Exit	KURA ONCOLOGY INC	$0	–	-240,500	–	-1.73%	–
GLPG	Exit	GALAPAGOS NVspon adr	$0	–	-39,609	–	-1.83%	–
ARNA	Exit	ARENA PHARMACEUTICALS INC	$0	–	-98,547	–	-1.86%	–
FOMX	Exit	FOAMIX PHARMACEUTICALS LTD	$0	–	-808,000	–	-1.90%	–
ARGX	Exit	ARGENX SEsponsored adr	$0	–	-64,300	–	-2.00%	–
BCRX	Exit	BIOCRYST PHARMACEUTICALS INC	$0	–	-652,086	–	-2.04%	–
PRQR	Exit	PROQR THERAPEUTICS N V	$0	–	-260,336	–	-2.07%	–
NBIX	Exit	NEUROCRINE BIOSCIENCES INC	$0	–	-41,008	–	-2.07%	–
DXCM	Exit	DEXCOM INC	$0	–	-37,000	–	-2.17%	–
ASND	Exit	ASCENDIS PHARMA A Ssponsored adr	$0	–	-77,242	–	-2.25%	–
AKBA	Exit	AKEBIA THERAPEUTICS INC	$0	–	-625,738	–	-2.27%	–
ALDR	Exit	ALDER BIOPHARMACEUTICALS INC	$0	–	-396,013	–	-2.71%	–
ZGNX	Exit	ZOGENIX INC	$0	–	-138,264	–	-2.82%	–
BPMC	Exit	BLUEPRINT MEDICINES CORP	$0	–	-92,691	–	-2.97%	–
AERI	Exit	AERIE PHARMACEUTICALS INC	$0	–	-132,770	–	-3.36%	–
NXTM	Exit	NXSTAGE MEDICAL INC	$0	–	-306,119	–	-3.51%	–
ATRC	Exit	ATRICURE INC	$0	–	-293,729	–	-4.22%	–
SAGE	Exit	SAGE THERAPEUTICS INC	$0	–	-99,306	–	-5.76%	–
STXS	Exit	STEREOTAXIS INC	$0	–	-13,680,554	–	-6.80%	–
LOXO	Exit	LOXO ONCOLOGY INC	$0	–	-169,675	–	-11.90%	–

Q3 2018

			Value		Shares		↓ Weighting
LOXO	Buy	LOXO ONCOLOGY INC	$28,986,000	+5.3%	169,675	+6.9%	11.90%	-7.6%
SAGE	Buy	SAGE THERAPEUTICS INC	$14,027,000	-6.7%	99,306	+3.4%	5.76%	-18.1%
ATRC	Sell	ATRICURE INC	$10,289,000	+20.6%	293,729	-6.9%	4.22%	+5.8%
AERI	Buy	AERIE PHARMACEUTICALS INC	$8,172,000	-8.2%	132,770	+0.8%	3.36%	-19.5%
ZGNX	Buy	ZOGENIX INC	$6,858,000	+58.7%	138,264	+41.4%	2.82%	+39.2%
AKBA	Buy	AKEBIA THERAPEUTICS INC	$5,525,000	-9.4%	625,738	+2.5%	2.27%	-20.5%
ASND	Buy	ASCENDIS PHARMA A Ssponsored adr	$5,473,000	+11.6%	77,242	+4.7%	2.25%	-2.2%
DXCM	Sell	DEXCOM INC	$5,292,000	+1.3%	37,000	-32.7%	2.17%	-11.2%
NBIX	Sell	NEUROCRINE BIOSCIENCES INC	$5,042,000	+12.8%	41,008	-9.9%	2.07%	-1.1%
PRQR	Buy	PROQR THERAPEUTICS N V	$5,038,000	+302.7%	260,336	+51.9%	2.07%	+253.1%
BCRX	Buy	BIOCRYST PHARMACEUTICALS INC	$4,975,000	+43.6%	652,086	+7.8%	2.04%	+26.0%
ARGX	Buy	ARGENX SEsponsored adr	$4,877,000	+126.8%	64,300	+147.8%	2.00%	+98.9%
FOMX	Buy	FOAMIX PHARMACEUTICALS LTD	$4,630,000	+173.5%	808,000	+139.1%	1.90%	+139.7%
ARNA	Buy	ARENA PHARMACEUTICALS INC	$4,535,000	+9.2%	98,547	+3.5%	1.86%	-4.2%
GLPG	Sell	GALAPAGOS NVspon adr	$4,453,000	+19.0%	39,609	-2.5%	1.83%	+4.3%
KURA	Buy	KURA ONCOLOGY INC	$4,209,000	-3.4%	240,500	+0.4%	1.73%	-15.3%
LMNX	Sell	LUMINEX CORP	$4,195,000	-16.4%	138,391	-18.5%	1.72%	-26.6%
IMMU	Sell	IMMUNOMEDICS INC	$3,708,000	-14.4%	178,000	-2.7%	1.52%	-24.9%
XENE	Sell	XENON PHARMACEUTICALS INC	$3,137,000	+15.8%	237,683	-19.3%	1.29%	+1.6%
ACHN	Sell	ACHILLION PHARMACEUTICALS	$3,119,000	+16.3%	847,636	-10.6%	1.28%	+2.0%
	Sell	INTEC PHARMA LTD JERUSALEM	$3,034,000	+21.3%	537,000	-5.6%	1.25%	+6.4%
BEAT	Sell	BIOTELEMETRY INC	$3,016,000	+23.0%	46,800	-14.1%	1.24%	+7.7%
BLUE	Buy	BLUEBIRD BIO INC	$2,993,000	+376.6%	20,500	+412.5%	1.23%	+318.0%
CARA	Buy	CARA THERAPEUTICS INC	$2,702,000	+124.6%	112,811	+79.6%	1.11%	+97.2%
AGTC	Sell	APPLIED GENETIC TECHNOL CORP	$2,627,000	+68.6%	359,860	-14.5%	1.08%	+48.0%
ARQL	Buy	ARQULE INC	$2,534,000	+143.0%	447,664	+137.3%	1.04%	+113.3%
CSII	Sell	CARDIOVASCULAR SYSTEMS INC	$2,200,000	+14.9%	56,200	-5.1%	0.90%	+0.7%
DRNA	Buy	DICERNA PHARMACEUTICALS INC	$1,808,000	+34.1%	118,500	+7.7%	0.74%	+17.6%
ADXS	Buy	ADVAXIS INC	$1,567,000	+55.0%	1,666,666	+139.1%	0.64%	+35.9%
SCYX	Sell	SCYNEXIS INC	$1,528,000	-27.0%	1,272,927	-0.2%	0.63%	-36.0%
TBIO	Buy	TRANSLATE BIO INC	$1,517,000	+499.6%	151,739	+658.7%	0.62%	+428.0%
NVAX	Sell	NOVAVAX INC	$1,316,000	+30.9%	700,000	-6.7%	0.54%	+14.6%
BHVN	Buy	BIOHAVEN PHARMACEUTICALS HOLD	$1,127,000	+21.3%	30,000	+27.7%	0.46%	+6.4%
LPTX	Sell	LEAP THERPEUTICS INC	$1,096,000	-19.7%	140,643	-7.3%	0.45%	-29.6%
ZFGN	Sell	ZAFGEN INC	$1,003,000	-40.0%	85,842	-47.5%	0.41%	-47.3%
OBSV	Sell	OBSEVA SA	$781,000	-20.6%	43,338	-33.3%	0.32%	-30.4%
SPRO	New	SPERO THERAPEUTICS INC	$736,000	–	70,000	–	0.30%	–
URGN	Buy	UROGEN PHARMA LTD	$708,000	+42.2%	15,000	+50.0%	0.29%	+24.9%
CYTK	Sell	CYTOKINETICS INC	$617,000	+7.1%	62,690	-9.7%	0.25%	-6.3%
APTX	Sell	APTINYX INC	$420,000	-30.5%	14,500	-42.0%	0.17%	-39.2%
STRO	New	SUTRO BIOPHARMA INC	$412,000	–	27,494	–	0.17%	–
ASMB	New	ASSEMBLY BIOSCIENCES INC	$396,000	–	10,673	–	0.16%	–
KALV	New	KALVISTA PHARMACEUTICALS INC	$392,000	–	17,725	–	0.16%	–
MASI	Sell	MASIMO CORPORATION	$374,000	-23.4%	3,000	-40.0%	0.15%	-32.5%
RDUS	Buy	RADIUS HEALTH INC	$365,000	+23.7%	20,500	+105.0%	0.15%	+8.7%
NERV	Sell	MINERVA NEUROSCIENCES INC	$338,000	-68.7%	26,907	-79.4%	0.14%	-72.5%
BTX	Sell	BIOTIME INC	$235,000	-37.2%	100,000	-44.9%	0.10%	-44.6%
KDMN	Sell	KADMON HOLDINGS INC	$210,000	-19.5%	63,000	-3.8%	0.09%	-29.5%
DERM	Sell	DERMIRA INC	$55,000	-74.1%	5,000	-78.3%	0.02%	-76.8%
FTSV	Exit	FORTY SEVEN INC	$0	–	-10,000	–	-0.08%	–
BGNE	Exit	BEIGENE LTDsponsored adr	$0	–	-2,000	–	-0.14%	–
GLMD	Exit	GALMED PHARMACEUTICALS LTD	$0	–	-50,000	–	-0.28%	–
	Exit	PROTALIX BIOTHERAPEUTICS INCnote 4.500% 9/1	$0	–	-2,500,000	–	-1.11%	–

Q2 2018

			Value		Shares		↓ Weighting
LOXO	New	LOXO ONCOLOGY INC	$27,527,000	–	158,675	–	12.89%	–
SAGE	New	SAGE THERAPEUTICS INC	$15,027,000	–	96,000	–	7.04%	–
STXS	New	STEREOTAXIS INC	$10,534,000	–	13,680,554	–	4.93%	–
AERI	New	AERIE PHARMACEUTICALS INC	$8,901,000	–	131,770	–	4.17%	–
NXTM	New	NXSTAGE MEDICAL INC	$8,541,000	–	306,119	–	4.00%	–
ATRC	New	ATRICURE INC	$8,530,000	–	315,345	–	3.99%	–
ALDR	New	ALDER BIOPHARMACEUTICALS INC	$6,257,000	–	396,013	–	2.93%	–
AKBA	New	AKEBIA THERAPEUTICS INC	$6,095,000	–	610,738	–	2.85%	–
BPMC	New	BLUEPRINT MEDICINES CORP	$5,884,000	–	92,691	–	2.76%	–
DXCM	New	DEXCOM INC	$5,224,000	–	55,000	–	2.45%	–
LMNX	New	LUMINEX CORP	$5,017,000	–	169,891	–	2.35%	–
ASND	New	ASCENDIS PHARMA A Ssponsored adr	$4,906,000	–	73,745	–	2.30%	–
NBIX	New	NEUROCRINE BIOSCIENCES INC	$4,471,000	–	45,508	–	2.09%	–
KURA	New	KURA ONCOLOGY INC	$4,359,000	–	239,500	–	2.04%	–
IMMU	New	IMMUNOMEDICS INC	$4,332,000	–	183,000	–	2.03%	–
ZGNX	New	ZOGENIX INC	$4,321,000	–	97,764	–	2.02%	–
ARNA	New	ARENA PHARMACEUTICALS INC	$4,153,000	–	95,242	–	1.94%	–
CBAY	New	CYMABAY THERAPEUTICS INC	$3,952,000	–	294,511	–	1.85%	–
GLPG	New	GALAPAGOS NVspon adr	$3,743,000	–	40,609	–	1.75%	–
	New	RADIUS HEALTH INCnote 3.000% 9/0	$3,725,000	–	4,000,000	–	1.74%	–
BCRX	New	BIOCRYST PHARMACEUTICALS INC	$3,465,000	–	604,652	–	1.62%	–
IBB	New	ISHARES TR NASDAQ BIOTECHetf	$2,866,000	–	26,100	–	1.34%	–
XENE	New	XENON PHARMACEUTICALS INC	$2,708,000	–	294,362	–	1.27%	–
ACHN	New	ACHILLION PHARMACEUTICALS	$2,682,000	–	947,636	–	1.26%	–
VBIV	New	VBI VACCINES INC	$2,570,000	–	934,691	–	1.20%	–
MNLO	New	MENLO THERAPEUTICS INC	$2,533,000	–	312,000	–	1.19%	–
	New	INTEC PHARMA LTD JERUSALEM	$2,502,000	–	568,600	–	1.17%	–
BEAT	New	BIOTELEMETRY INC	$2,453,000	–	54,500	–	1.15%	–
	New	PROTALIX BIOTHERAPEUTICS INCnote 4.500% 9/1	$2,375,000	–	2,500,000	–	1.11%	–
ARGX	New	ARGENX SEsponsored adr	$2,150,000	–	25,949	–	1.01%	–
SCYX	New	SCYNEXIS INC	$2,092,000	–	1,275,527	–	0.98%	–
CSII	New	CARDIOVASCULAR SYSTEMS INC	$1,915,000	–	59,200	–	0.90%	–
WVE	New	WAVE LIFE SCIENCES LTD	$1,832,000	–	47,900	–	0.86%	–
ARDX	New	ARDELYX INC	$1,750,000	–	472,859	–	0.82%	–
FOMX	New	FOAMIX PHARMACEUTICALS LTD	$1,693,000	–	338,000	–	0.79%	–
ZFGN	New	ZAFGEN INC	$1,671,000	–	163,377	–	0.78%	–
	New	INSULET CORPnote 1.375%	$1,664,000	–	1,500,000	–	0.78%	–
MGNX	New	MACROGENICS INC	$1,617,000	–	78,305	–	0.76%	–
AGTC	New	APPLIED GENETIC TECHNOL CORP	$1,558,000	–	421,000	–	0.73%	–
IMDZ	New	IMMUNE DESIGN CORP	$1,495,000	–	328,500	–	0.70%	–
INCY	New	INCYTE CORP	$1,441,000	–	21,500	–	0.68%	–
LPTX	New	LEAP THERPEUTICS INC	$1,365,000	–	151,643	–	0.64%	–
DRNA	New	DICERNA PHARMACEUTICALS INC	$1,348,000	–	110,000	–	0.63%	–
NTUS	New	NATUS MEDICAL INC	$1,308,000	–	37,900	–	0.61%	–
PRQR	New	PROQR THERAPEUTICS N V	$1,251,000	–	171,351	–	0.59%	–
CARA	New	CARA THERAPEUTICS INC	$1,203,000	–	62,811	–	0.56%	–
JNJ	New	JOHNSON AND JOHNSON	$1,141,000	–	9,400	–	0.53%	–
CDTX	New	CIDARA THERAPEUTICS INC	$1,106,000	–	212,766	–	0.52%	–
NERV	New	MINERVA NEUROSCIENCES INC	$1,080,000	–	130,872	–	0.51%	–
ARQL	New	ARQULE INC	$1,043,000	–	188,664	–	0.49%	–
ADXS	New	ADVAXIS INC	$1,011,000	–	697,000	–	0.47%	–
NVAX	New	NOVAVAX INC	$1,005,000	–	750,000	–	0.47%	–
OBSV	New	OBSEVA SA	$984,000	–	64,977	–	0.46%	–
BHVN	New	BIOHAVEN PHARMACEUTICALS HOLD	$929,000	–	23,500	–	0.44%	–
SNSS	New	SUNESIS PHARMACEUTICALS INC	$792,000	–	373,702	–	0.37%	–
NTGN	New	NEON THERAPEUICS INC	$630,000	–	50,000	–	0.30%	–
BLUE	New	BLUEBIRD BIO INC	$628,000	–	4,000	–	0.29%	–
APTX	New	APTINYX INC	$604,000	–	25,000	–	0.28%	–
GLMD	New	GALMED PHARMACEUTICALS LTD	$595,000	–	50,000	–	0.28%	–
CYTK	New	CYTOKINETICS INC	$576,000	–	69,437	–	0.27%	–
URGN	New	UROGEN PHARMA LTD	$498,000	–	10,000	–	0.23%	–
MASI	New	MASIMO CORPORATION	$488,000	–	5,000	–	0.23%	–
RIGL	New	RIGEL PHARMACEUTICALS INC	$389,000	–	137,600	–	0.18%	–
BTX	New	BIOTIME INC	$374,000	–	181,600	–	0.18%	–
BGNE	New	BEIGENE LTDsponsored adr	$307,000	–	2,000	–	0.14%	–
RDUS	New	RADIUS HEALTH INC	$295,000	–	10,000	–	0.14%	–
	New	DEXCOM INCdbcv 0.750% 5/1	$288,000	–	250,000	–	0.14%	–
SLGL	New	SOL GEL TECHNOLOGIES LTD	$270,000	–	35,000	–	0.13%	–
KDMN	New	KADMON HOLDINGS INC	$261,000	–	65,500	–	0.12%	–
	New	ALDER BIOPHARMACEUTICALS INCnote 2.500% 2/0	$261,000	–	250,000	–	0.12%	–
TBIO	New	TRANSLATE BIO INC	$253,000	–	20,000	–	0.12%	–
BLCM	New	BELLICUM PHARMACEUTICALS INC	$221,000	–	30,000	–	0.10%	–
DERM	New	DERMIRA INC	$212,000	–	23,000	–	0.10%	–
NEOS	New	NEOS THERAPEUTICS INC	$172,000	–	27,500	–	0.08%	–
FTSV	New	FORTY SEVEN INC	$160,000	–	10,000	–	0.08%	–

Q4 2017

			Value		Shares		↓ Weighting
GALE	Exit	GALENA BIOPHARMA INC	$0	–	-46,145	–	-0.01%	–
SRRA	Exit	SIERRA ONCOLOGY INC	$0	–	-44,000	–	-0.04%	–
CTMX	Exit	CYTOMX THERAPEUTICS INC	$0	–	-5,900	–	-0.07%	–
SBPH	Exit	SPRING BANK PHARMACEUTICALS	$0	–	-6,507	–	-0.07%	–
	Exit	INTEC PHARMA LTD JERUSALEM	$0	–	-14,100	–	-0.08%	–
ADMP	Exit	ADAMIS PHARMACEUTICALS CORP	$0	–	-24,401	–	-0.08%	–
OPHT	Exit	OPHTHOTECH CORP	$0	–	-50,000	–	-0.09%	–
ATNM	Exit	ACTINIUM PHARMACEUTICALS INC	$0	–	-333,000	–	-0.12%	–
EDGE	Exit	EDGE THERAPEUTICS INC	$0	–	-19,400	–	-0.13%	–
	Exit	DEXCOM INCdbcv 0.750% 5/1	$0	–	-250,000	–	-0.14%	–
BLCM	Exit	BELLICUM PHARMACEUTICALS INC	$0	–	-20,000	–	-0.14%	–
NEOS	Exit	NEOS THERAPEUTICS INC	$0	–	-27,500	–	-0.16%	–
NTUS	Exit	NATUS MEDICAL INC DEL	$0	–	-7,900	–	-0.18%	–
DCPH	Exit	DECIPHERA PHARMACEUTICALS IN	$0	–	-20,000	–	-0.24%	–
KDMN	Exit	KADMON HOLDINGS INC	$0	–	-125,000	–	-0.26%	–
MASI	Exit	MASIMO CORPORATION	$0	–	-5,000	–	-0.27%	–
	Exit	INOTEK PHARMACEUTICALS CORPnote 5.750% 8/0	$0	–	-600,000	–	-0.29%	–
ARQL	Exit	ARQULE INC	$0	–	-427,478	–	-0.30%	–
CASC	Exit	CASCADIAN THERAPEUTICS INC	$0	–	-117,310	–	-0.30%	–
LMNX	Exit	LUMINEX CORP DEL	$0	–	-25,000	–	-0.32%	–
BLUE	Exit	BLUEBIRD BIO INC	$0	–	-4,500	–	-0.38%	–
	Exit	IRONWOOD PHARMACEUTICALS INCdbcv 2.250% 6/1	$0	–	-573,000	–	-0.42%	–
OBSV	Exit	OBSEVA SA	$0	–	-86,000	–	-0.44%	–
CGNT	Exit	COGENTIX MEDICAL INC	$0	–	-323,482	–	-0.51%	–
ARGX	Exit	ARGENX SEsponsored adr	$0	–	-40,000	–	-0.56%	–
EXAC	Exit	EXACTECH INC	$0	–	-27,532	–	-0.56%	–
CMTA	Exit	CLEMENTIA PHARMACEUTICALS IN	$0	–	-60,000	–	-0.63%	–
ADXS	Exit	ADVAXIS INC	$0	–	-247,000	–	-0.64%	–
XENE	Exit	XENON PHARMACEUTICALS INC	$0	–	-377,695	–	-0.69%	–
STXS	Exit	STEREOTAXIS INC	$0	–	-1,372,862	–	-0.70%	–
RIGL	Exit	RIGEL PHARMACEUTICALS INC	$0	–	-443,478	–	-0.70%	–
AQXP	Exit	AQUINOX PHARMACEUTICALS INC	$0	–	-79,542	–	-0.70%	–
JNJ	Exit	JOHNSON AND JOHNSON	$0	–	-9,400	–	-0.76%	–
SCYX	Exit	SCYNEXIS INC	$0	–	-506,900	–	-0.76%	–
CARA	Exit	CARA THERAPEUTICS INC	$0	–	-93,800	–	-0.80%	–
NERV	Exit	MINERVA NEUROSCIENCES INC	$0	–	-171,094	–	-0.81%	–
FOMX	Exit	FOAMIX PHARMACEUTICALS LTD	$0	–	-258,667	–	-0.89%	–
	Exit	NEURODERM LTD	$0	–	-37,938	–	-0.92%	–
KURA	Exit	KURA ONCOLOGY INC	$0	–	-105,859	–	-0.98%	–
SNSS	Exit	SUNESIS PHARMACEUTICALS INC	$0	–	-831,332	–	-1.00%	–
	Exit	DERMIRA INCnote 3.000% 5/1	$0	–	-1,500,000	–	-1.01%	–
BEAT	Exit	BIOTELEMETRY INC	$0	–	-50,000	–	-1.02%	–
AGTC	Exit	APPLIED GENETIC TECHNOL CORP	$0	–	-421,000	–	-1.03%	–
QURE	Exit	UNIQURE N V	$0	–	-175,307	–	-1.04%	–
CDTX	Exit	CIDARA THERAPEUTICS INC	$0	–	-208,458	–	-1.05%	–
AGLE	Exit	AEGLEA BIOTHERAPEUTICS INC	$0	–	-349,592	–	-1.07%	–
ARDX	Exit	ARDELYX INC	$0	–	-325,409	–	-1.13%	–
ZGNX	Exit	ZOGENIX INC	$0	–	-52,500	–	-1.14%	–
DERM	Exit	DERMIRA INC	$0	–	-75,500	–	-1.27%	–
RDUS	Exit	RADIUS HEALTH INC	$0	–	-53,309	–	-1.28%	–
	Exit	PROTALIX BIOTHERAPEUTICS INCnote 4.500% 9/1	$0	–	-2,500,000	–	-1.32%	–
VYGR	Exit	VOYAGER THERAPEUTICS INC	$0	–	-117,259	–	-1.50%	–
ASND	Exit	ASCENDIS PHARMA A Ssponsored adr	$0	–	-72,226	–	-1.63%	–
AKBA	Exit	AKEBIA THERAPEUTICS INC	$0	–	-135,738	–	-1.66%	–
	Exit	INSULET CORPnote 2.000% 6/1	$0	–	-2,250,000	–	-1.75%	–
DXCM	Exit	DEXCOM INC	$0	–	-57,500	–	-1.75%	–
MGNX	Exit	MACROGENICS INC	$0	–	-154,200	–	-1.77%	–
IBB	Exit	ISHARES TR NASDQ BIOTECHetf	$0	–	-8,700	–	-1.80%	–
PODD	Exit	INSULET CORP	$0	–	-57,484	–	-1.97%	–
GLPG	Exit	GALAPAGOS NVspon adr	$0	–	-31,609	–	-2.00%	–
ACHN	Exit	ACHILLION PHARMACEUTICALS	$0	–	-718,272	–	-2.00%	–
NBIX	Exit	NEUROCRINE BIOSCIENCES INC	$0	–	-54,508	–	-2.07%	–
CBAY	Exit	CYMABAY THERAPEUTICS INC	$0	–	-435,000	–	-2.18%	–
	Exit	RADIUS HEALTH INCnote 3.000% 9/0	$0	–	-4,000,000	–	-2.48%	–
ALDR	Exit	ALDER BIOPHARMACEUTICALS INC	$0	–	-346,013	–	-2.63%	–
BPMC	Exit	BLUEPRINT MEDICINES CORP	$0	–	-76,000	–	-3.29%	–
AERI	Exit	AERIE PHARMACEUTICALS INC	$0	–	-116,770	–	-3.52%	–
NXTM	Exit	NXSTAGE MEDICAL INC	$0	–	-216,119	–	-3.70%	–
BCRX	Exit	BIOCRYST PHARMACEUTICALS INC	$0	–	-1,193,228	–	-3.88%	–
IMMU	Exit	IMMUNOMEDICS INC	$0	–	-460,451	–	-4.00%	–
BGNE	Exit	BEIGENE LTDsponsored adr	$0	–	-71,849	–	-4.62%	–
ATRC	Exit	ATRICURE INC	$0	–	-384,145	–	-5.34%	–
LOXO	Exit	LOXO ONCOLOGY INC	$0	–	-262,121	–	-14.99%	–

Q3 2017

			Value		Shares		↓ Weighting
LOXO	Sell	LOXO ONCOLOGY INC	$24,147,000	-0.8%	262,121	-13.7%	14.99%	-13.7%
BGNE	Sell	BEIGENE LTDsponsored adr	$7,433,000	+126.1%	71,849	-1.6%	4.62%	+96.7%
IMMU	Sell	IMMUNOMEDICS INC	$6,437,000	+14.3%	460,451	-27.8%	4.00%	-0.5%
BCRX	Buy	BIOCRYST PHARMACEUTICALS INC	$6,253,000	+90.2%	1,193,228	+101.9%	3.88%	+65.5%
AERI	Buy	AERIE PHARMACEUTICALS INC	$5,675,000	+1.1%	116,770	+9.4%	3.52%	-12.0%
BPMC	Sell	BLUEPRINT MEDICINES CORP	$5,295,000	+27.4%	76,000	-7.3%	3.29%	+10.9%
ALDR	Buy	ALDER BIOPHARMACEUTICALS INC	$4,239,000	+67.5%	346,013	+56.6%	2.63%	+45.7%
	New	RADIUS HEALTH INCnote 3.000% 9/0	$4,000,000	–	4,000,000	–	2.48%	–
CBAY	Buy	CYMABAY THERAPEUTICS INC	$3,506,000	+3087.3%	435,000	+2181.4%	2.18%	+2691.0%
ACHN	Buy	ACHILLION PHARMACEUTICALS	$3,225,000	+163.7%	718,272	+169.5%	2.00%	+129.3%
GLPG	Sell	GALAPAGOS NVspon adr	$3,216,000	+8.9%	31,609	-18.1%	2.00%	-5.3%
PODD	Sell	INSULET CORP	$3,166,000	-2.8%	57,484	-9.5%	1.97%	-15.4%
MGNX	Buy	MACROGENICS INC	$2,850,000	+36.6%	154,200	+29.4%	1.77%	+18.9%
DXCM	New	DEXCOM INC	$2,813,000	–	57,500	–	1.75%	–
ASND	Buy	ASCENDIS PHARMA A Ssponsored adr	$2,618,000	+183.9%	72,226	+117.5%	1.63%	+147.1%
VYGR	Sell	VOYAGER THERAPEUTICS INC	$2,414,000	+31.6%	117,259	-42.7%	1.50%	+14.5%
ZGNX	Sell	ZOGENIX INC	$1,840,000	+127.4%	52,500	-5.9%	1.14%	+97.9%
ARDX	Sell	ARDELYX INC	$1,822,000	-4.3%	325,409	-12.9%	1.13%	-16.8%
QURE	Sell	UNIQURE N V	$1,683,000	+33.4%	175,307	-14.0%	1.04%	+16.0%
BEAT	Sell	BIOTELEMETRY INC	$1,650,000	-34.2%	50,000	-33.3%	1.02%	-42.7%
SNSS	Sell	SUNESIS PHARMACEUTICALS INC	$1,613,000	-29.7%	831,332	-2.2%	1.00%	-38.8%
KURA	New	KURA ONCOLOGY INC	$1,583,000	–	105,859	–	0.98%	–
FOMX	Sell	FOAMIX PHARMACEUTICALS LTD	$1,436,000	-13.0%	258,667	-27.3%	0.89%	-24.2%
NERV	Sell	MINERVA NEUROSCIENCES INC	$1,300,000	-46.8%	171,094	-38.1%	0.81%	-53.8%
CARA	New	CARA THERAPEUTICS INC	$1,284,000	–	93,800	–	0.80%	–
AQXP	New	AQUINOX PHARMACEUTICALS INC	$1,129,000	–	79,542	–	0.70%	–
CMTA	New	CLEMENTIA PHARMACEUTICALS IN	$1,013,000	–	60,000	–	0.63%	–
EXAC	Buy	EXACTECH INC	$907,000	+31.6%	27,532	+19.0%	0.56%	+14.4%
CGNT	Sell	COGENTIX MEDICAL INC	$828,000	+34.6%	323,482	-8.5%	0.51%	+17.1%
OBSV	Buy	OBSEVA SA	$700,000	+227.1%	86,000	+244.0%	0.44%	+184.3%
BLUE	Sell	BLUEBIRD BIO INC	$618,000	-26.4%	4,500	-43.8%	0.38%	-35.9%
LMNX	New	LUMINEX CORP DEL	$508,000	–	25,000	–	0.32%	–
ARQL	Sell	ARQULE INC	$475,000	-51.2%	427,478	-45.5%	0.30%	-57.5%
MASI	Buy	MASIMO CORPORATION	$433,000	+11.6%	5,000	+17.6%	0.27%	-2.9%
KDMN	New	KADMON HOLDINGS INC	$419,000	–	125,000	–	0.26%	–
DCPH	New	DECIPHERA PHARMACEUTICALS IN	$380,000	–	20,000	–	0.24%	–
NEOS	Sell	NEOS THERAPEUTICS INC	$252,000	-83.6%	27,500	-86.9%	0.16%	-85.7%
ATNM	New	ACTINIUM PHARMACEUTICALS INC	$192,000	–	333,000	–	0.12%	–
OPHT	New	OPHTHOTECH CORP	$141,000	–	50,000	–	0.09%	–
	New	INTEC PHARMA LTD JERUSALEM	$126,000	–	14,100	–	0.08%	–
SBPH	Buy	SPRING BANK PHARMACEUTICALS	$110,000	-49.3%	6,507	+306.7%	0.07%	-56.1%
CTMX	New	CYTOMX THERAPEUTICS INC	$107,000	–	5,900	–	0.07%	–
SRRA	Sell	SIERRA ONCOLOGY INC	$68,000	-78.1%	44,000	-83.4%	0.04%	-81.0%
	Exit	TRILLIUM THERAPEUTICS INC	$0	–	-20,000	–	-0.06%	–
ANAB	Exit	ANAPTYSBIO INC	$0	–	-5,500	–	-0.09%	–
ARRY	Exit	ARRAY BIOPHARMA INC	$0	–	-20,000	–	-0.12%	–
AFMD	Exit	AFFIMED N V	$0	–	-92,500	–	-0.14%	–
ARNA	Exit	ARENA PHARMACEUTICALS INC	$0	–	-15,550	–	-0.19%	–
EIGR	Exit	EIGER BIOPHARMACEUTICALS INC	$0	–	-35,977	–	-0.20%	–
CNAT	Exit	CONATUS PHARMACEUTICALS INC	$0	–	-50,000	–	-0.21%	–
GEMP	Exit	GEMPHIRE THERAPEUTICS INC	$0	–	-30,797	–	-0.28%	–
ITEK	Exit	INOTEK PHARMACEUTICALS CORP	$0	–	-237,135	–	-0.32%	–
TNDM	Exit	TANDEM DIABETES CARE INC	$0	–	-724,286	–	-0.41%	–
BLRX	Exit	BIOLINERX LTDsponsored adr	$0	–	-980,352	–	-0.59%	–
ELOS	Exit	SYNERON MEDICAL LTD	$0	–	-85,947	–	-0.67%	–
CLLS	Exit	CELLECTIS S Asponsored adr	$0	–	-76,404	–	-1.41%	–
SGMO	Exit	SANGAMO THERAPEUTICS INC	$0	–	-225,000	–	-1.41%	–
SPNC	Exit	SPECTRANETICS CORP	$0	–	-55,896	–	-1.53%	–

Q2 2017

			Value		Shares		↓ Weighting
LOXO	New	LOXO ONCOLOGY INC	$24,347,000	–	303,621	–	17.37%	–
ATRC	New	ATRICURE INC	$9,316,000	–	384,145	–	6.65%	–
IMMU	New	IMMUNOMEDICS INC	$5,631,000	–	637,700	–	4.02%	–
AERI	New	AERIE PHARMACEUTICALS INC	$5,611,000	–	106,770	–	4.00%	–
NXTM	New	NXSTAGE MEDICAL INC	$5,418,000	–	216,119	–	3.87%	–
BPMC	New	BLUEPRINT MEDICINES CORP	$4,155,000	–	82,000	–	2.96%	–
BCRX	New	BIOCRYST PHARMACEUTICALS INC	$3,287,000	–	591,128	–	2.35%	–
BGNE	New	BEIGENE LTDsponsored adr	$3,287,000	–	73,036	–	2.35%	–
PODD	New	INSULET CORP	$3,257,000	–	63,484	–	2.32%	–
GLPG	New	GALAPAGOS NVspon adr	$2,954,000	–	38,609	–	2.11%	–
	New	INSULET CORPnote 2.000% 6/1	$2,746,000	–	2,250,000	–	1.96%	–
IBB	New	ISHARES TR NASDQ BIOTECetf	$2,698,000	–	8,700	–	1.92%	–
ALDR	New	ALDER BIOPHARMACEUTICALS INC	$2,531,000	–	221,013	–	1.81%	–
BEAT	New	BIOTELEMETRY INC	$2,509,000	–	75,000	–	1.79%	–
NBIX	New	NEUROCRINE BIOSCIENCES INC	$2,507,000	–	54,508	–	1.79%	–
NERV	New	MINERVA NEUROSCIENCES INC	$2,445,000	–	276,317	–	1.74%	–
RDUS	New	RADIUS HEALTH INC	$2,411,000	–	53,309	–	1.72%	–
SNSS	New	SUNESIS PHARMACEUTICALS INC	$2,296,000	–	850,328	–	1.64%	–
DERM	New	DERMIRA INC	$2,200,000	–	75,500	–	1.57%	–
AGTC	New	APPLIED GENETIC TECHNOL CORP	$2,147,000	–	421,000	–	1.53%	–
SPNC	New	SPECTRANETICS CORP	$2,146,000	–	55,896	–	1.53%	–
MGNX	New	MACROGENICS INC	$2,087,000	–	119,200	–	1.49%	–
SGMO	New	SANGAMO THERAPEUTICS INC	$1,980,000	–	225,000	–	1.41%	–
CLLS	New	CELLECTIS S Asponsored adr	$1,973,000	–	76,404	–	1.41%	–
AKBA	New	AKEBIA THERAPEUTICS INC	$1,951,000	–	135,738	–	1.39%	–
	New	PROTALIX BIOTHERAPEUTICS INCnote 4.500% 9/1	$1,936,000	–	2,500,000	–	1.38%	–
ARDX	New	ARDELYX INC	$1,904,000	–	373,409	–	1.36%	–
VYGR	New	VOYAGER THERAPEUTICS INC	$1,835,000	–	204,808	–	1.31%	–
	New	DERMIRA INCnote 3.000% 5/1	$1,665,000	–	1,500,000	–	1.19%	–
FOMX	New	FOAMIX PHARMACEUTICALS LTD	$1,650,000	–	355,667	–	1.18%	–
ADXS	New	ADVAXIS INC	$1,603,000	–	247,000	–	1.14%	–
CDTX	New	CIDARA THERAPEUTICS INC	$1,563,000	–	208,458	–	1.12%	–
NEOS	New	NEOS THERAPEUTICS INC	$1,532,000	–	209,873	–	1.09%	–
AGLE	New	AEGLEA BIOTHERAPEUTICS INC	$1,346,000	–	349,592	–	0.96%	–
QURE	New	UNIQURE N V	$1,262,000	–	203,907	–	0.90%	–
JNJ	New	JOHNSON AND JOHNSON	$1,244,000	–	9,400	–	0.89%	–
ACHN	New	ACHILLION PHARMACEUTICALS	$1,223,000	–	266,500	–	0.87%	–
RIGL	New	RIGEL PHARMACEUTICALS INC	$1,211,000	–	443,478	–	0.86%	–
XENE	New	XENON PHARMACEUTICALS INC	$1,190,000	–	377,695	–	0.85%	–
	New	NEURODERM LTD	$1,134,000	–	37,938	–	0.81%	–
ARQL	New	ARQULE INC	$973,000	–	784,508	–	0.69%	–
ELOS	New	SYNERON MEDICAL LTD	$941,000	–	85,947	–	0.67%	–
ASND	New	ASCENDIS PHARMA A Ssponsored adr	$922,000	–	33,214	–	0.66%	–
SCYX	New	SCYNEXIS INC	$907,000	–	506,900	–	0.65%	–
ARGX	New	ARGENX SEsponsored adr	$848,000	–	40,000	–	0.60%	–
BLUE	New	BLUEBIRD BIO INC	$840,000	–	8,000	–	0.60%	–
BLRX	New	BIOLINERX LTDsponsored adr	$828,000	–	980,352	–	0.59%	–
ZGNX	New	ZOGENIX INC	$809,000	–	55,809	–	0.58%	–
STXS	New	STEREOTAXIS INC	$796,000	–	1,372,862	–	0.57%	–
	New	IRONWOOD PHARMACEUTICALS INCdbcv 2.250% 6/1	$767,000	–	573,000	–	0.55%	–
EXAC	New	EXACTECH INC	$689,000	–	23,136	–	0.49%	–
CGNT	New	COGENTIX MEDICAL INC	$615,000	–	353,482	–	0.44%	–
TNDM	New	TANDEM DIABETES CARE INC	$579,000	–	724,286	–	0.41%	–
ITEK	New	INOTEK PHARMACEUTICALS CORP	$451,000	–	237,135	–	0.32%	–
CASC	New	CASCADIAN THERAPEUTICS INC	$436,000	–	117,310	–	0.31%	–
GEMP	New	GEMPHIRE THERAPEUTICS INC	$394,000	–	30,797	–	0.28%	–
MASI	New	MASIMO CORPORATION	$388,000	–	4,250	–	0.28%	–
	New	INOTEK PHARMACEUTICALS CORPnote 5.750% 8/0	$369,000	–	600,000	–	0.26%	–
SRRA	New	SIERRA ONCOLOGY INC	$310,000	–	265,000	–	0.22%	–
NTUS	New	NATUS MDICAL INC DEL	$295,000	–	7,900	–	0.21%	–
CNAT	New	CONATUS PHARMACEUTICALS INC	$288,000	–	50,000	–	0.21%	–
EIGR	New	EIGER BIOPHARMACEUTICALS INC	$284,000	–	35,977	–	0.20%	–
ARNA	New	ARENA PHARMACEUTICALS INC	$262,000	–	15,550	–	0.19%	–
	New	DEXCOM INCdbcv 0.750% 5/1	$254,000	–	250,000	–	0.18%	–
BLCM	New	BELLICUM PHARMACEUTICALS INC	$234,000	–	20,000	–	0.17%	–
SBPH	New	SPRING BANK PHARMACEUTICALS	$217,000	–	1,600	–	0.16%	–
OBSV	New	OBSEVA SA	$214,000	–	25,000	–	0.15%	–
EDGE	New	EDGE THERAPEUTICS INC	$199,000	–	19,400	–	0.14%	–
AFMD	New	AFFIMED N V	$190,000	–	92,500	–	0.14%	–
ARRY	New	ARRAY BIOPHARMA INC	$167,000	–	20,000	–	0.12%	–
ANAB	New	ANAPTYSBIO INC	$132,000	–	5,500	–	0.09%	–
ADMP	New	ADAMIS PHARMACEUTICALS CORP	$127,000	–	24,401	–	0.09%	–
CBAY	New	CYMABAY THERAPEUTICS INC	$110,000	–	19,067	–	0.08%	–
	New	TRILLIUM THERAPEUTICS INC	$88,000	–	20,000	–	0.06%	–
GALE	New	GALENA BIOPHARMA INC	$27,000	–	46,145	–	0.02%	–

Q4 2016

			Value		Shares		↓ Weighting
ETRM	Exit	ENTEROMEDICS INC COM PAR 0.01	$0	–	-33,334	–	-0.00%	–
CHEKW	Exit	CHECK CAP LTD*w exp 02/28/202	$0	–	-51,218	–	-0.02%	–
CVM	Exit	CEL SCI CORP	$0	–	-127,482	–	-0.03%	–
GNVC	Exit	GENVEC INC	$0	–	-95,800	–	-0.03%	–
CBIO	Exit	CATALYST BIOSCIENCES INC	$0	–	-70,903	–	-0.06%	–
NVLS	Exit	NIVALIS THERAPEUTICS INC	$0	–	-15,000	–	-0.08%	–
AVGR	Exit	AVINGER INC	$0	–	-30,800	–	-0.10%	–
PTN	Exit	PALATIN TECHNOLOGIES INC	$0	–	-257,193	–	-0.11%	–
NEOS	Exit	NEOS THERAPEUTICS INC	$0	–	-38,873	–	-0.18%	–
DXTRQ	Exit	DEXTERA SURGICAL INC	$0	–	-140,275	–	-0.18%	–
AQXP	Exit	AQUINOX PHARMACEUTICALS INC	$0	–	-20,000	–	-0.19%	–
	Exit	NEURODERM LTD	$0	–	-14,421	–	-0.19%	–
CYAD	Exit	CELYADadr	$0	–	-12,528	–	-0.21%	–
IMDZ	Exit	IMMUNE DESIGN CORP	$0	–	-40,000	–	-0.21%	–
BLUE	Exit	BLUEBIRD BIO INC	$0	–	-6,000	–	-0.28%	–
PIRS	Exit	PIERIS PHARMACEUTICALS INC	$0	–	-223,325	–	-0.28%	–
NERV	Exit	MINERVA NEUROSCIENCES INC	$0	–	-33,100	–	-0.32%	–
ARRY	Exit	ARRAY BIOPHARMA INC	$0	–	-69,300	–	-0.33%	–
INNL	Exit	INNOCOLL HLDGS PLC	$0	–	-100,000	–	-0.40%	–
MASI	Exit	MASIMO CORPORATION	$0	–	-10,000	–	-0.41%	–
ELOS	Exit	SYNERON MEDICAL LTD	$0	–	-85,947	–	-0.43%	–
ASND	Exit	ASCENDIS PHARMAsponsored adr	$0	–	-30,750	–	-0.43%	–
CGNT	Exit	COGENTIX MEDICAL INC	$0	–	-353,482	–	-0.45%	–
CNCE	Exit	CONCERT PHARMACEUTICALS INC	$0	–	-66,968	–	-0.47%	–
DRNA	Exit	DICERNA PHARMACEUTICALS INC	$0	–	-119,300	–	-0.49%	–
	Exit	IRONWOOD PHARMACEUTICALS INCdbcv 2.250% 6/1	$0	–	-600,000	–	-0.50%	–
	Exit	ESSA PHARMA INC	$0	–	-195,496	–	-0.51%	–
	Exit	INOTEK PHARMACEUTICALS CORPnote 5.750% 8/0 added	$0	–	-600,000	–	-0.55%	–
SCYX	Exit	SCYNEXIS INC	$0	–	-213,250	–	-0.58%	–
EXAC	Exit	EXACTECH INC	$0	–	-31,636	–	-0.60%	–
ZGNX	Exit	ZOGENIX INC	$0	–	-79,538	–	-0.63%	–
JNJ	Exit	JOHNSON AND JOHNSON	$0	–	-9,400	–	-0.77%	–
NVDQ	Exit	NOVADAQ TECHNOLOGIES INC	$0	–	-101,841	–	-0.82%	–
STXS	Exit	STEREOTAXIS INC	$0	–	-1,372,862	–	-0.83%	–
EIGR	Exit	EIGER BIOPHARMACEUTICALS INC	$0	–	-90,000	–	-0.84%	–
WINT	Exit	WINDTREE THERAPEUTICS INC	$0	–	-480,833	–	-0.86%	–
RIGL	Exit	RIGEL PHARMACEUTICALS INC	$0	–	-340,000	–	-0.87%	–
RGLS	Exit	REGULUS THERAPEUTICS INC	$0	–	-421,500	–	-0.97%	–
BEAT	Exit	BIOTELEMETRY INC	$0	–	-80,000	–	-1.04%	–
ACHN	Exit	ACHILLION PHARMACEUTICALS	$0	–	-186,500	–	-1.05%	–
SGYPQ	Exit	SYNERGY PHARMACEUTICALS	$0	–	-274,563	–	-1.05%	–
	Exit	PROTALIX BIOTHERAPEUTICS INCnote 4.500% 9/1	$0	–	-2,500,000	–	-1.06%	–
QURE	Exit	UNIQURE B.V.	$0	–	-203,907	–	-1.09%	–
MGNX	Exit	MACROGENICS INC	$0	–	-54,200	–	-1.13%	–
SPNC	Exit	SPECTRANETICS CORP	$0	–	-65,496	–	-1.14%	–
DSCI	Exit	DERMA SCIENCES INC	$0	–	-353,718	–	-1.15%	–
CYTK	Exit	CYTOKINETICS INC	$0	–	-181,737	–	-1.16%	–
BSTC	Exit	BIOSPECIFICS TECHNOLOGIES	$0	–	-39,704	–	-1.26%	–
IMMU	Exit	IMMUNOMEDICS INC	$0	–	-566,796	–	-1.28%	–
RDUS	Exit	RADIUS HEALTH INC	$0	–	-36,854	–	-1.39%	–
OPHT	Exit	OPHTHOTECH CORP	$0	–	-46,600	–	-1.50%	–
CARA	Exit	CARA THERAPEUTICS INC	$0	–	-267,046	–	-1.55%	–
AGLE	Exit	AEGLEA BIOTHERAPEUTICS INC	$0	–	-350,392	–	-1.56%	–
ITEK	Exit	INOTEK PHARMACEUTICALS CORP	$0	–	-237,235	–	-1.57%	–
AGTC	Exit	APPLIED GENETIC TECHNOL CORP	$0	–	-240,298	–	-1.64%	–
	Exit	INSULET CORPnote 2.000% 6/1	$0	–	-2,250,000	–	-1.73%	–
FOMX	Exit	FOAMIX PHARMACEUTICALS LTD	$0	–	-278,067	–	-1.79%	–
PTGX	Exit	PROTAGONIST THERAPEUTICS INC	$0	–	-123,804	–	-1.82%	–
BGNE	Exit	BEIGENE LTDsponsored adr	$0	–	-90,142	–	-1.93%	–
ARDX	Exit	ARDELYX INC	$0	–	-219,095	–	-1.98%	–
TSRO	Exit	TESARO INC	$0	–	-29,500	–	-2.06%	–
PODD	Exit	INSULET CORP	$0	–	-73,484	–	-2.10%	–
NBIX	Exit	NEUROCRINE BIOSCIENCES INC	$0	–	-64,008	–	-2.26%	–
DERM	Exit	DERMIRA INC	$0	–	-98,800	–	-2.33%	–
LOXO	Exit	LOXO ONCOLOGY INC	$0	–	-130,222	–	-2.37%	–
AERI	Exit	AERIE PHARMACEUTICALS INC	$0	–	-91,869	–	-2.42%	–
XENE	Exit	XENON PHARMACEUTICALS INC	$0	–	-514,091	–	-2.90%	–
GLPG	Exit	GALAPAGOS NVspon adr	$0	–	-66,068	–	-2.98%	–
ALDR	Exit	ALDER BIOPHARMACEUTICALS INC	$0	–	-165,313	–	-3.77%	–
TNDM	Exit	TANDEM DIABETES CARE INC	$0	–	-724,286	–	-3.86%	–
NXTM	Exit	NXSTAGE MEDICAL INC	$0	–	-238,509	–	-4.15%	–
ATRC	Exit	ATRICURE INC	$0	–	-528,946	–	-5.83%	–
CYNA	Exit	CYNAPSUS THERAPEUTICS INC	$0	–	-230,201	–	-6.45%	–
VTAE	Exit	VITAE PHARMACEUTICALS INC	$0	–	-715,988	–	-10.43%	–

Q3 2016

			Value		Shares		↓ Weighting
VTAE	Buy	VITAE PHARMACEUTICALS INC	$14,978,000	+110.3%	715,988	+8.5%	10.43%	+84.8%
CYNA	Buy	CYNAPSUS THERAPEUTICS INC	$9,256,000	+149.0%	230,201	+3.5%	6.45%	+118.8%
ATRC	Buy	ATRICURE INC	$8,368,000	+15.2%	528,946	+2.9%	5.83%	+1.3%
NXTM	Sell	NXSTAGE MEDICAL INC	$5,960,000	-22.9%	238,509	-33.1%	4.15%	-32.2%
TNDM	Buy	TANDEM DIABETES CARE INC	$5,548,000	+135.3%	724,286	+131.6%	3.86%	+106.7%
GLPG	Buy	GALAPAGOS NVspon adr	$4,272,000	+21.2%	66,068	+3.9%	2.98%	+6.4%
XENE	Buy	XENON PHARMACEUTICALS INC	$4,164,000	+229.7%	514,091	+140.1%	2.90%	+189.7%
AERI	Sell	AERIE PHARMACEUTICALS INC	$3,467,000	+22.5%	91,869	-42.9%	2.42%	+7.6%
LOXO	Buy	LOXO ONCOLOGY INC	$3,409,000	+44.2%	130,222	+27.7%	2.37%	+26.7%
DERM	Sell	DERMIRA INC	$3,341,000	-41.0%	98,800	-49.0%	2.33%	-48.2%
NBIX	Sell	NEUROCRINE BIOSCIENCES INC	$3,241,000	-5.6%	64,008	-15.2%	2.26%	-17.0%
PODD	Sell	INSULET CORP	$3,008,000	+7.9%	73,484	-20.3%	2.10%	-5.2%
TSRO	Sell	TESARO INC	$2,957,000	+17.2%	29,500	-1.7%	2.06%	+3.0%
ARDX	Buy	ARDELYX INC	$2,835,000	+982.1%	219,095	+630.3%	1.98%	+849.5%
BGNE	Buy	BEIGENE LTDsponsored adr	$2,777,000	+365.9%	90,142	+350.7%	1.93%	+309.7%
PTGX	New	PROTAGONIST THERAPEUTICS INC	$2,616,000	–	123,804	–	1.82%	–
FOMX	Buy	FOAMIX PHARMACEUTICALS LTD	$2,575,000	+110.5%	278,067	+44.4%	1.79%	+85.0%
	Sell	INSULET CORPnote 2.000% 6/1	$2,481,000	+8.2%	2,250,000	-6.5%	1.73%	-5.0%
AGTC	Buy	APPLIED GENETIC TECHNOL CORP	$2,350,000	-0.5%	240,298	+43.7%	1.64%	-12.6%
ITEK	New	INOTEK PHARMACEUTICALS CORP	$2,249,000	–	237,235	–	1.57%	–
OPHT	New	OPHTHOTECH CORP	$2,150,000	–	46,600	–	1.50%	–
RDUS	Sell	RADIUS HEALTH INC	$1,993,000	+44.2%	36,854	-2.0%	1.39%	+26.8%
IMMU	Sell	IMMUNOMEDICS INC	$1,842,000	-2.6%	566,796	-30.5%	1.28%	-14.4%
CYTK	Buy	CYTOKINETICS INC	$1,668,000	+17.1%	181,737	+21.2%	1.16%	+2.9%
SPNC	Sell	SPECTRANETICS CORP	$1,643,000	+10.0%	65,496	-17.9%	1.14%	-3.3%
QURE	Buy	UNIQURE B.V.	$1,560,000	+33.2%	203,907	+28.3%	1.09%	+17.1%
SGYPQ	Sell	SYNERGY PHARMACEUTICALS	$1,513,000	+24.6%	274,563	-14.1%	1.05%	+9.6%
ACHN	Sell	ACHILLION PHARMACEUTICALS	$1,511,000	-18.1%	186,500	-21.1%	1.05%	-28.0%
BEAT	Sell	BIOTELEMETRY INC	$1,486,000	-8.8%	80,000	-20.0%	1.04%	-19.9%
RIGL	Sell	RIGEL PHARMACEUTICALS INC	$1,248,000	-69.7%	340,000	-81.6%	0.87%	-73.4%
WINT	Sell	WINDTREE THERAPEUTICS INC	$1,231,000	+19.6%	480,833	-9.8%	0.86%	+5.0%
EIGR	New	EIGER BIOPHARMACEUTICALS INC	$1,205,000	–	90,000	–	0.84%	–
ZGNX	Sell	ZOGENIX INC	$909,000	-42.8%	79,538	-59.7%	0.63%	-49.8%
SCYX	Sell	SCYNEXIS INC	$825,000	+42.5%	213,250	-20.1%	0.58%	+25.3%
	New	INOTEK PHARMACEUTICALS CORPnote 5.750% 8/0 added	$794,000	–	600,000	–	0.55%	–
	Sell	ESSA PHARMA INC	$733,000	-9.5%	195,496	-3.5%	0.51%	-20.4%
CGNT	Buy	COGENTIX MEDICAL INC	$643,000	+89.7%	353,482	+0.2%	0.45%	+66.5%
ASND	Sell	ASCENDIS PHARMAsponsored adr	$618,000	-12.6%	30,750	-42.2%	0.43%	-23.2%
ARRY	New	ARRAY BIOPHARMA INC	$468,000	–	69,300	–	0.33%	–
NERV	Sell	MINERVA NEUROSCIENCES INC	$467,000	-42.9%	33,100	-58.7%	0.32%	-49.8%
BLUE	Sell	BLUEBIRD BIO INC	$407,000	-21.6%	6,000	-50.0%	0.28%	-31.1%
IMDZ	New	IMMUNE DESIGN CORP	$303,000	–	40,000	–	0.21%	–
CYAD	New	CELYADadr	$296,000	–	12,528	–	0.21%	–
AQXP	New	AQUINOX PHARMACEUTICALS INC	$267,000	–	20,000	–	0.19%	–
PTN	New	PALATIN TECHNOLOGIES INC	$162,000	–	257,193	–	0.11%	–
AVGR	New	AVINGER INC	$147,000	–	30,800	–	0.10%	–
CHEKW	Sell	CHECK CAP LTD*w exp 02/28/202	$29,000	+480.0%	51,218	-4.2%	0.02%	+400.0%
ONTX	Exit	ONCONOVA THERAPEUTICS INC	$0	–	-200	–	-0.00%	–
AKTX	Exit	AKARI THERAPEUTICS PLCsponsored adr	$0	–	-458	–	-0.01%	–
ALDX	Exit	ALDEYRA THERAPEUTICS INC	$0	–	-2,499	–	-0.01%	–
ATRS	Exit	ANTARES PHARMA INC	$0	–	-45,000	–	-0.04%	–
MRNS	Exit	MARINUS PHARMACEUTICALS INC	$0	–	-90,237	–	-0.09%	–
CHEK	Exit	CHECK CAP LTD	$0	–	-88,220	–	-0.10%	–
CASC	Exit	CASCADIAN THERAPEUTICS INC	$0	–	-175,000	–	-0.13%	–
VTGN	Exit	VISTAGEN THERAPEUTICS INC	$0	–	-46,900	–	-0.14%	–
AKBA	Exit	AKEBIA THERAPEUTICS INC	$0	–	-24,700	–	-0.15%	–
ADAP	Exit	ADAPTIMMUNE THERAPEUTICS PLCsponds adr	$0	–	-24,955	–	-0.16%	–
TENX	Exit	TENAX THERAPEUTICS INC	$0	–	-79,509	–	-0.16%	–
GLYC	Exit	GLYCOMIMETICS INC	$0	–	-27,996	–	-0.16%	–
BPMC	Exit	BLUEPRINT MEDICINES CORP	$0	–	-10,100	–	-0.16%	–
SNSS	Exit	SUNESIS PHARMACEUTICALS INC	$0	–	-423,336	–	-0.18%	–
AVEO	Exit	AVEO PHARMACEUTICALS INC	$0	–	-259,067	–	-0.20%	–
NMUS	Exit	NEMUS BIOSCIENCE INC	$0	–	-511,508	–	-0.20%	–
ABUS	Exit	ARBUTUS BIOPHARMA CORP	$0	–	-75,000	–	-0.21%	–
VTVT	Exit	VTV THERAPEUTICS INCcl a	$0	–	-73,000	–	-0.34%	–
ABEO	Exit	ABEONA THERAPEUTICS INC	$0	–	-181,818	–	-0.34%	–
ADVM	Exit	ADVERUM BIOTECHNOLOGIES INC	$0	–	-140,600	–	-0.35%	–
TTPH	Exit	TETRAPHASE PHARMACEUTICALS I	$0	–	-103,690	–	-0.35%	–
	Exit	TARGACEPT INCnote 2/1	$0	–	-530,821	–	-0.42%	–
	Exit	INTEC PHARMA LTD JERUSALEM	$0	–	-119,296	–	-0.44%	–
	Exit	CYNAPSUS THERAPEUTICS INC	$0	–	-33,995	–	-0.45%	–
GERN	Exit	GERON CORP	$0	–	-285,000	–	-0.61%	–
LDRH	Exit	LDR HLDG CORP	$0	–	-30,000	–	-0.88%	–
AKAOQ	Exit	ACHAOGEN INC COM	$0	–	-314,341	–	-0.94%	–
CRBP	Exit	CORBUS PHARMACEUTICALS HLDGS	$0	–	-400,000	–	-0.95%	–
IBB	Exit	ISHARES TR NASDQ BIOTECetf	$0	–	-6,000	–	-1.22%	–
NVAX	Exit	NOVAVAX INC	$0	–	-550,000	–	-3.17%	–
ABBV	Exit	ABBVIE INC	$0	–	-76,331	–	-3.75%	–

Q2 2016

			Value		Shares		↓ Weighting
NXTM	New	NXSTAGE MEDICAL INC	$7,729,000	–	356,509	–	6.13%	–
ATRC	New	ATRICURE INC	$7,262,000	–	513,946	–	5.76%	–
VTAE	New	VITAE PHARMACEUTICALS INC	$7,123,000	–	660,188	–	5.64%	–
DERM	New	DERMIRA INC	$5,664,000	–	193,642	–	4.49%	–
ABBV	New	ABBVIE INC	$4,726,000	–	76,331	–	3.75%	–
ALDR	New	ALDER BIOPHARMACEUTICALS INC	$4,128,000	–	165,313	–	3.27%	–
RIGL	New	RIGEL PHARMACEUTICALS INC	$4,119,000	–	1,847,087	–	3.26%	–
NVAX	New	NOVAVAX INC	$3,999,000	–	550,000	–	3.17%	–
CYNA	New	CYNAPSUS THERAPEUTICS INC	$3,718,000	–	222,359	–	2.95%	–
GLPG	New	GALAPAGOS NVspon adr	$3,526,000	–	63,568	–	2.80%	–
NBIX	New	NEUROCRINE BIOSCIENCES INC	$3,432,000	–	75,503	–	2.72%	–
AERI	New	AERIE PHARMACEUTICALS INC	$2,831,000	–	160,869	–	2.24%	–
PODD	New	INSULET CORP	$2,787,000	–	92,164	–	2.21%	–
TSRO	New	TESARO INC	$2,522,000	–	30,000	–	2.00%	–
LOXO	New	LOXO ONCOLOGY INC	$2,364,000	–	101,966	–	1.87%	–
AGTC	New	APPLIED GENETIC TECHNOL CORP	$2,362,000	–	167,192	–	1.87%	–
TNDM	New	TANDEM DIABETES CARE INC	$2,358,000	–	312,756	–	1.87%	–
	New	INSULET CORPnote 2.000% 6/1	$2,294,000	–	2,407,000	–	1.82%	–
IMMU	New	IMMUNOMEDICS INC	$1,891,000	–	815,000	–	1.50%	–
ACHN	New	ACHILLION PHARMACEUTICALS	$1,845,000	–	236,500	–	1.46%	–
AGLE	New	AEGLEA BIOTHERAPEUTICS INC	$1,703,000	–	350,392	–	1.35%	–
	New	PROTALIX BIOTHERAPEUTICS INCnote 4.500% 9/1	$1,644,000	–	2,500,000	–	1.30%	–
BEAT	New	BIOTELEMETRY INC	$1,630,000	–	100,000	–	1.29%	–
ZGNX	New	ZOGENIX INC	$1,590,000	–	197,538	–	1.26%	–
BSTC	New	BIOSPECIFICS TECHNOLOGIES	$1,586,000	–	39,704	–	1.26%	–
IBB	New	ISHARES TR NASDQ BIOTECetf	$1,544,000	–	6,000	–	1.22%	–
SPNC	New	SPECTRANETICS CORP	$1,493,000	–	79,812	–	1.18%	–
MGNX	New	MACROGENICS INC	$1,463,000	–	54,200	–	1.16%	–
CYTK	New	CYTOKINETICS INC	$1,424,000	–	150,000	–	1.13%	–
DSCI	New	DERMA SCIENCES INC	$1,394,000	–	353,718	–	1.10%	–
RDUS	New	RADIUS HEALTH INC	$1,382,000	–	37,600	–	1.10%	–
STXS	New	STEREOTAXIS INC	$1,345,000	–	1,372,862	–	1.07%	–
CARA	New	CARA THERAPEUTICS INC	$1,284,000	–	267,046	–	1.02%	–
XENE	New	XENON PHARMACEUTICALS INC	$1,263,000	–	214,091	–	1.00%	–
FOMX	New	FOAMIX PHARMACEUTICALS LTD	$1,223,000	–	192,567	–	0.97%	–
RGLS	New	REGULUS THERAPEUTICS INC	$1,218,000	–	421,500	–	0.96%	–
SGYPQ	New	SYNERGY PHARMACEUTICALS	$1,214,000	–	319,563	–	0.96%	–
CRBP	New	CORBUS PHARMACEUTICALS HLDGS	$1,196,000	–	400,000	–	0.95%	–
AKAOQ	New	ACHAOGEN INC COM	$1,191,000	–	314,341	–	0.94%	–
QURE	New	UNIQURE B.V.	$1,171,000	–	158,907	–	0.93%	–
JNJ	New	JOHNSON AND JOHNSON	$1,140,000	–	9,400	–	0.90%	–
LDRH	New	LDR HLDG CORP	$1,109,000	–	30,000	–	0.88%	–
WINT	New	WINDTREE THERAPEUTICS INC	$1,029,000	–	533,358	–	0.82%	–
NVDQ	New	NOVADAQ TECHNOLOGIES INC	$1,002,000	–	101,841	–	0.79%	–
EXAC	New	EXACTECH INC	$846,000	–	31,636	–	0.67%	–
NERV	New	MINERVA NEUROSCIENCES INC	$818,000	–	80,100	–	0.65%	–
	New	ESSA PHARMA INC	$810,000	–	202,496	–	0.64%	–
GERN	New	GERON CORP	$764,000	–	285,000	–	0.61%	–
CNCE	New	CONCERT PHARMACEUTICALS INC	$752,000	–	66,968	–	0.60%	–
ASND	New	ASCENDIS PHARMAsponsored adr	$707,000	–	53,241	–	0.56%	–
ELOS	New	SYNERON MEDICAL LTD	$661,000	–	85,947	–	0.52%	–
	New	IRONWOOD PHARMACEUTICALS INCdbcv 2.250% 6/1 added	$620,000	–	600,000	–	0.49%	–
BGNE	New	BEIGENE LTDsponsored adr added	$596,000	–	20,000	–	0.47%	–
SCYX	New	SCYNEXIS INC	$579,000	–	266,904	–	0.46%	–
	New	CYNAPSUS THERAPEUTICS INC	$564,000	–	33,995	–	0.45%	–
INNL	New	INNOCOLL HLDGS PLC	$551,000	–	100,000	–	0.44%	–
	New	INTEC PHARMA LTD JERUSALEM	$549,000	–	119,296	–	0.44%	–
	New	TARGACEPT INCnote 2/1	$531,000	–	530,821	–	0.42%	–
MASI	New	MASIMO CORPORATION	$525,000	–	10,000	–	0.42%	–
BLUE	New	BLUEBIRD BIO INC	$519,000	–	12,000	–	0.41%	–
TTPH	New	TETRAPHASE PHARMACEUTICALS I	$446,000	–	103,690	–	0.35%	–
ADVM	New	ADVERUM BIOTECHNOLOGIES INC	$444,000	–	140,600	–	0.35%	–
ABEO	New	ABEONA THERAPEUTICS INC	$429,000	–	181,818	–	0.34%	–
VTVT	New	VTV THERAPEUTICS INCcl a	$423,000	–	73,000	–	0.34%	–
NEOS	New	NEOS THERAPEUTICS INC	$361,000	–	38,873	–	0.29%	–
PIRS	New	PIERIS PHARMACEUTICALS INC	$360,000	–	223,325	–	0.28%	–
DRNA	New	DICERNA PHARMACEUTICALS INC	$358,000	–	119,300	–	0.28%	–
CGNT	New	COGENTIX MEDICAL INC	$339,000	–	352,882	–	0.27%	–
ARDX	New	ARDELYX INC	$262,000	–	30,000	–	0.21%	–
ABUS	New	ARBUTUS BIOPHARMA CORP	$261,000	–	75,000	–	0.21%	–
DXTRQ	New	DEXTERA SURGICAL INC	$252,000	–	140,275	–	0.20%	–
NMUS	New	NEMUS BIOSCIENCE INC	$252,000	–	511,508	–	0.20%	–
AVEO	New	AVEO PHARMACEUTICALS INC	$249,000	–	259,067	–	0.20%	–
	New	NEURODERM LTD	$234,000	–	14,421	–	0.18%	–
SNSS	New	SUNESIS PHARMACEUTICALS INC	$232,000	–	423,336	–	0.18%	–
TENX	New	TENAX THERAPEUTICS INC	$204,000	–	79,509	–	0.16%	–
GLYC	New	GLYCOMIMETICS INC	$204,000	–	27,996	–	0.16%	–
BPMC	New	BLUEPRINT MEDICINES CORP	$205,000	–	10,100	–	0.16%	–
ADAP	New	ADAPTIMMUNE THERAPEUTICS PLCsponds adr	$203,000	–	24,955	–	0.16%	–
AKBA	New	AKEBIA THERAPEUTICS INC	$185,000	–	24,700	–	0.15%	–
VTGN	New	VISTAGEN THERAPEUTICS INC	$183,000	–	46,900	–	0.14%	–
CASC	New	CASCADIAN THERAPEUTICS INC	$165,000	–	175,000	–	0.13%	–
CHEK	New	CHECK CAP LTD	$123,000	–	88,220	–	0.10%	–
MRNS	New	MARINUS PHARMACEUTICALS INC	$115,000	–	90,237	–	0.09%	–
CBIO	New	CATALYST BIOSCIENCES INC	$108,000	–	70,903	–	0.09%	–
NVLS	New	NIVALIS THERAPEUTICS INC	$69,000	–	15,000	–	0.06%	–
CVM	New	CEL SCI CORP	$59,000	–	127,482	–	0.05%	–
GNVC	New	GENVEC INC	$55,000	–	95,800	–	0.04%	–
ATRS	New	ANTARES PHARMA INC	$47,000	–	45,000	–	0.04%	–
ALDX	New	ALDEYRA THERAPEUTICS INC	$14,000	–	2,499	–	0.01%	–
ETRM	New	ENTEROMEDICS INC COM PAR 0.01	$10,000	–	33,334	–	0.01%	–
AKTX	New	AKARI THERAPEUTICS PLCsponsored adr	$6,000	–	458	–	0.01%	–
CHEKW	New	CHECK CAP LTD*w exp 02/28/202	$5,000	–	53,488	–	0.00%	–
ONTX	New	ONCONOVA THERAPEUTICS INC	$1,000	–	200	–	0.00%	–

Q4 2015

			Value		Shares		↓ Weighting
CHEKW	Exit	CHECK CAP LTD*w exp 02/28/202	$0	–	-55,000	–	-0.03%	–
GLMD	Exit	GALMED PHARMACEUTICALS LTD	$0	–	-5,871	–	-0.04%	–
ADXS	Exit	ADVAXIS INC	$0	–	-5,000	–	-0.05%	–
GLPG	Exit	GALAPAGOS NV-SPON ADRadr	$0	–	-1,709	–	-0.07%	–
ATRS	Exit	ANTARES PHARMA INC	$0	–	-45,000	–	-0.08%	–
CRBP	Exit	CORBUS PHARMACEUTICALS HLDGS	$0	–	-50,000	–	-0.08%	–
	Exit	APTOSE BIOSCIENCES INC	$0	–	-19,239	–	-0.08%	–
CVM	Exit	CEL SCI CORP	$0	–	-139,500	–	-0.08%	–
CEMI	Exit	CHEMBIO DIAGNOSTICS INC	$0	–	-21,722	–	-0.09%	–
ONTY	Exit	ONCOTHYREON INC	$0	–	-36,180	–	-0.10%	–
CASM	Exit	CAS MEDICAL SYSTEMS INC	$0	–	-86,768	–	-0.11%	–
ETRM	Exit	ENTEROMEDICS INC	$0	–	-500,000	–	-0.13%	–
TRVN	Exit	TREVENA INC	$0	–	-14,800	–	-0.15%	–
ATNM	Exit	ACTINIUM PHARMACEUTICALS INC	$0	–	-90,000	–	-0.16%	–
DNAI	Exit	PRONAI THERAPEUTICS INC	$0	–	-8,500	–	-0.17%	–
MRNS	Exit	MARINUS PHARMACEUTICALS INC	$0	–	-22,319	–	-0.18%	–
NVLS	Exit	NIVALIS THERAPEUTICS INC	$0	–	-15,000	–	-0.19%	–
APPY	Exit	VENAXIS INC	$0	–	-650,400	–	-0.20%	–
LOXO	Exit	LOXO ONCOLOGY INC	$0	–	-11,745	–	-0.20%	–
XENE	Exit	XENON PHARMACEUTICALS INC	$0	–	-25,000	–	-0.20%	–
GNVC	Exit	GENVEC INC	$0	–	-95,800	–	-0.22%	–
TENX	Exit	TENAX THERAPEUTICS INC	$0	–	-81,509	–	-0.24%	–
CHEK	Exit	CHECK CAP LTD	$0	–	-109,900	–	-0.30%	–
TNDM	Exit	TANDEM DIABETES CARE INC	$0	–	-36,551	–	-0.32%	–
CBIO	Exit	CATALYST BIOSCIENCES INC	$0	–	-70,903	–	-0.33%	–
CRDC	Exit	CARDICA INC	$0	–	-1,402,762	–	-0.38%	–
ICPT	Exit	INTERCEPT PHARMACEUTICALS IN	$0	–	-2,430	–	-0.40%	–
LMNS	Exit	LUMENIS LTD	$0	–	-31,072	–	-0.43%	–
CGNT	Exit	COGENTIX MEDICAL INC	$0	–	-351,781	–	-0.43%	–
TBRA	Exit	TOBIRA THERAPEUTICS INC	$0	–	-45,092	–	-0.43%	–
VTVT	Exit	VTV THERAPEUTICS INC- CL Acl a added	$0	–	-75,000	–	-0.48%	–
AMGN	Exit	AMGEN INC	$0	–	-3,700	–	-0.51%	–
BLUE	Exit	BLUEBIRD BIO INC	$0	–	-6,000	–	-0.51%	–
MGNX	Exit	MACROGENICS INC	$0	–	-24,000	–	-0.51%	–
DERM	Exit	DERMIRA INC	$0	–	-22,500	–	-0.52%	–
	Exit	TARGACEPT INCnote 0.0% 19-feb-2018 unsecured conv	$0	–	-530,821	–	-0.53%	–
LPCN	Exit	LIPOCINE INC	$0	–	-45,000	–	-0.53%	–
	Exit	CYNAPSUS THERAPEUTICS INC	$0	–	-33,995	–	-0.53%	–
	Exit	IRONWOOD PHARMAnote 2.25% 15-jun-2022 144a sr unsecured conv	$0	–	-600,000	–	-0.53%	–
EXAC	Exit	EXACTECH INC	$0	–	-31,636	–	-0.55%	–
GILD	Exit	GILEAD SCIENCES INC	$0	–	-5,700	–	-0.56%	–
CELG	Exit	CELGENE CORP	$0	–	-5,200	–	-0.56%	–
CDNA	Exit	CAREDX INC	$0	–	-135,927	–	-0.56%	–
RGLS	Exit	REGULUS THERAPEUTICS INC	$0	–	-90,000	–	-0.58%	–
ALDR	Exit	ALDER BIOPHARMACEUTICALS INC	$0	–	-18,000	–	-0.58%	–
ELOS	Exit	SYNERON MEDICAL LTD	$0	–	-85,947	–	-0.61%	–
AKTX	Exit	AKARI THERAPEUTICS PLCadr added	$0	–	-26,390	–	-0.63%	–
CYNA	Exit	CYNAPSUS THERAPEUTICS INC	$0	–	-44,824	–	-0.70%	–
QURE	Exit	UNIQURE B.V.	$0	–	-35,000	–	-0.71%	–
ARNA	Exit	ARENA PHARMACEUTICALS INC	$0	–	-381,600	–	-0.72%	–
ABEO	Exit	ABEONA THERAPEUTICS INC	$0	–	-181,818	–	-0.73%	–
	Exit	INTEC PHARMA LTD	$0	–	-135,000	–	-0.75%	–
VTAE	Exit	VITAE PHARMACEUTICALS INC	$0	–	-70,885	–	-0.77%	–
JNJ	Exit	JOHNSON AND JOHNSON	$0	–	-9,400	–	-0.87%	–
ZGNX	Exit	ZOGENIX INC	$0	–	-68,900	–	-0.92%	–
SPNC	Exit	SPECTRANETICS CORP	$0	–	-79,812	–	-0.93%	–
ASND	Exit	ASCENDIS PHARMAadr	$0	–	-53,241	–	-0.94%	–
	Exit	NUVASIVE INCnote 2.750% 7/0	$0	–	-760,000	–	-0.95%	–
DRNA	Exit	DICERNA PHARMACEUTICALS INC	$0	–	-123,500	–	-1.01%	–
NVDQ	Exit	NOVADAQ TECHNOLOGIES INC	$0	–	-101,841	–	-1.05%	–
SCYX	Exit	SCYNEXIS INC	$0	–	-156,904	–	-1.13%	–
AAVL	Exit	AVALANCHE BIOTECHNOLOGIES IN	$0	–	-140,600	–	-1.15%	–
CYAD	Exit	CELYADadr	$0	–	-30,000	–	-1.25%	–
STXS	Exit	STEREOTAXIS INC	$0	–	-1,372,862	–	-1.26%	–
NEOS	Exit	NEOS THERAPEUTICS INC	$0	–	-63,400	–	-1.32%	–
CARA	Exit	CARA THERAPEUTICS INC	$0	–	-93,574	–	-1.33%	–
CYTR	Exit	CYTRX CORP	$0	–	-583,013	–	-1.37%	–
PLX	Exit	PROTALIX BIOTHERAPEUTICS INC	$0	–	-1,193,189	–	-1.40%	–
	Exit	ESSA PHARMA INC	$0	–	-228,500	–	-1.41%	–
SGYPQ	Exit	SYNERGY PHARMACEUTICALS	$0	–	-296,563	–	-1.56%	–
XNPT	Exit	XENOPORT INC	$0	–	-470,612	–	-1.62%	–
DSCI	Exit	DERMA SCIENCES INC	$0	–	-356,918	–	-1.67%	–
MASI	Exit	MASIMO CORPORATION	$0	–	-46,010	–	-1.76%	–
OTIC	Exit	OTONOMY INC	$0	–	-111,466	–	-1.97%	–
AGTC	Exit	APPLIED GENETIC TECHNOL CORP	$0	–	-157,192	–	-2.05%	–
	Exit	INSULET CORPnote 2.000% 6/1	$0	–	-2,407,000	–	-2.21%	–
DSCO	Exit	DISCOVERY LABORATORIES INC	$0	–	-7,508,544	–	-2.24%	–
	Exit	PROTALIX BIOTHERAPEUTICS INCnote 4.500% 9/1	$0	–	-4,000,000	–	-2.68%	–
RIGL	Exit	RIGEL PHARMACEUTICALS INC	$0	–	-1,109,740	–	-2.72%	–
PODD	Exit	INSULET CORP	$0	–	-106,018	–	-2.73%	–
BEAT	Exit	BIOTELEMETRY INC	$0	–	-235,645	–	-2.86%	–
AERI	Exit	AERIE PHARMACEUTICALS INC	$0	–	-165,669	–	-2.92%	–
BCRX	Exit	BIOCRYST PHARMACEUTICALS INC	$0	–	-258,642	–	-2.93%	–
ACHN	Exit	ACHILLION PHARMACEUTICALS	$0	–	-480,300	–	-3.29%	–
ZSPH	Exit	ZS PHARMA INC	$0	–	-66,194	–	-4.31%	–
NXTM	Exit	NXSTAGE MEDICAL INC	$0	–	-366,554	–	-5.74%	–
ABBV	Exit	ABBVIE INC	$0	–	-116,581	–	-6.29%	–
ATRC	Exit	ATRICURE INC	$0	–	-487,946	–	-10.61%	–

Q3 2015

			Value		Shares		↓ Weighting
ATRC	Sell	ATRICURE INC	$10,691,000	-20.9%	487,946	-11.1%	10.61%	-7.2%
ZSPH	Sell	ZS PHARMA INC	$4,346,000	+23.6%	66,194	-1.4%	4.31%	+45.0%
BCRX	Buy	BIOCRYST PHARMACEUTICALS INC	$2,949,000	-10.9%	258,642	+16.7%	2.93%	+4.5%
AERI	Buy	AERIE PHARMACEUTICALS INC	$2,939,000	+6.2%	165,669	+5.6%	2.92%	+24.6%
DSCO	Buy	DISCOVERY LABORATORIES INC	$2,253,000	-30.9%	7,508,544	+56.6%	2.24%	-18.9%
DSCI	Sell	DERMA SCIENCES INC	$1,681,000	-37.2%	356,918	-4.5%	1.67%	-26.3%
XNPT	Sell	XENOPORT INC	$1,633,000	-49.8%	470,612	-11.4%	1.62%	-41.2%
SGYPQ	Sell	SYNERGY PHARMACEUTICALS	$1,572,000	-40.4%	296,563	-6.6%	1.56%	-30.0%
	Sell	ESSA PHARMA INC	$1,424,000	-45.8%	228,500	-1.2%	1.41%	-36.4%
PLX	Sell	PROTALIX BIOTHERAPEUTICS INC	$1,408,000	-41.3%	1,193,189	-3.1%	1.40%	-31.2%
CYTR	Buy	CYTRX CORP	$1,382,000	+23.5%	583,013	+93.8%	1.37%	+44.9%
CARA	Sell	CARA THERAPEUTICS INC	$1,337,000	-13.4%	93,574	-26.3%	1.33%	+1.7%
NEOS	New	NEOS THERAPEUTICS INC	$1,332,000	–	63,400	–	1.32%	–
AAVL	New	AVALANCHE BIOTECHNOLOGIES IN	$1,159,000	–	140,600	–	1.15%	–
SCYX	Sell	SCYNEXIS INC	$1,142,000	-19.5%	156,904	-2.8%	1.13%	-5.6%
DRNA	Buy	DICERNA PHARMACEUTICALS INC	$1,014,000	-16.3%	123,500	+42.3%	1.01%	-1.8%
ASND	Sell	ASCENDIS PHARMAadr	$942,000	-43.0%	53,241	-43.1%	0.94%	-33.2%
SPNC	Buy	SPECTRANETICS CORP	$941,000	+2.7%	79,812	+100.5%	0.93%	+20.5%
ZGNX	Sell	ZOGENIX INC	$930,000	-35.1%	68,900	-91.9%	0.92%	-23.9%
VTAE	New	VITAE PHARMACEUTICALS INC	$780,000	–	70,885	–	0.77%	–
	New	INTEC PHARMA LTD	$756,000	–	135,000	–	0.75%	–
ABEO	New	ABEONA THERAPEUTICS INC	$736,000	–	181,818	–	0.73%	–
ARNA	Buy	ARENA PHARMACEUTICALS INC	$729,000	-16.9%	381,600	+101.9%	0.72%	-2.6%
QURE	Sell	UNIQURE B.V.	$716,000	-33.7%	35,000	-12.5%	0.71%	-22.2%
CYNA	Sell	CYNAPSUS THERAPEUTICS INC	$707,000	-59.1%	44,824	-52.7%	0.70%	-52.0%
AKTX	New	AKARI THERAPEUTICS PLCadr added	$633,000	–	26,390	–	0.63%	–
ELOS	Sell	SYNERON MEDICAL LTD	$615,000	-36.3%	85,947	-5.5%	0.61%	-25.3%
ALDR	New	ALDER BIOPHARMACEUTICALS INC	$590,000	–	18,000	–	0.58%	–
RGLS	New	REGULUS THERAPEUTICS INC	$589,000	–	90,000	–	0.58%	–
CDNA	Sell	CAREDX INC	$567,000	-40.1%	135,927	-6.7%	0.56%	-29.7%
CELG	New	CELGENE CORP	$562,000	–	5,200	–	0.56%	–
GILD	New	GILEAD SCIENCES INC	$560,000	–	5,700	–	0.56%	–
	Buy	IRONWOOD PHARMAnote 2.25% 15-jun-2022 144a sr unsecured conv	$537,000	+35.6%	600,000	+50.0%	0.53%	+59.1%
LPCN	Sell	LIPOCINE INC	$532,000	-27.0%	45,000	-47.1%	0.53%	-14.4%
	New	TARGACEPT INCnote 0.0% 19-feb-2018 unsecured conv	$531,000	–	530,821	–	0.53%	–
DERM	Sell	DERMIRA INC	$525,000	-47.3%	22,500	-60.3%	0.52%	-38.1%
MGNX	New	MACROGENICS INC	$514,000	–	24,000	–	0.51%	–
AMGN	New	AMGEN INC	$512,000	–	3,700	–	0.51%	–
VTVT	New	VTV THERAPEUTICS INC- CL Acl a added	$489,000	–	75,000	–	0.48%	–
CGNT	Sell	COGENTIX MEDICAL INC	$436,000	-23.8%	351,781	-0.4%	0.43%	-10.5%
TBRA	New	TOBIRA THERAPEUTICS INC	$436,000	–	45,092	–	0.43%	–
ICPT	Buy	INTERCEPT PHARMACEUTICALS IN	$403,000	-16.6%	2,430	+21.5%	0.40%	-2.2%
CRDC	Sell	CARDICA INC	$379,000	-48.9%	1,402,762	-5.6%	0.38%	-40.1%
CBIO	New	CATALYST BIOSCIENCES INC	$330,000	–	70,903	–	0.33%	–
TNDM	Buy	TANDEM DIABETES CARE INC	$322,000	-17.4%	36,551	+1.6%	0.32%	-3.0%
CHEK	Sell	CHECK CAP LTD	$307,000	-20.3%	109,900	-0.1%	0.30%	-6.4%
TENX	New	TENAX THERAPEUTICS INC	$245,000	–	81,509	–	0.24%	–
GNVC	Sell	GENVEC INC	$221,000	+8.3%	95,800	-4.2%	0.22%	+26.6%
XENE	New	XENON PHARMACEUTICALS INC	$207,000	–	25,000	–	0.20%	–
LOXO	Sell	LOXO ONCOLOGY INC	$205,000	-7.2%	11,745	-4.1%	0.20%	+8.6%
APPY	Sell	VENAXIS INC	$200,000	-32.2%	650,400	-1.2%	0.20%	-20.8%
DNAI	New	PRONAI THERAPEUTICS INC	$174,000	–	8,500	–	0.17%	–
TRVN	New	TREVENA INC	$153,000	–	14,800	–	0.15%	–
ETRM	New	ENTEROMEDICS INC	$130,000	–	500,000	–	0.13%	–
CASM	Sell	CAS MEDICAL SYSTEMS INC	$108,000	-4.4%	86,768	-2.0%	0.11%	+11.5%
CEMI	Sell	CHEMBIO DIAGNOSTICS INC	$88,000	-31.8%	21,722	-17.4%	0.09%	-20.2%
CVM	Sell	CEL SCI CORP	$84,000	-59.8%	139,500	-55.9%	0.08%	-53.1%
	Sell	APTOSE BIOSCIENCES INC	$83,000	-76.9%	19,239	-72.7%	0.08%	-73.0%
CRBP	Buy	CORBUS PHARMACEUTICALS HLDGS	$79,000	-30.1%	50,000	+36.6%	0.08%	-18.8%
GLPG	New	GALAPAGOS NV-SPON ADRadr	$70,000	–	1,709	–	0.07%	–
ADXS	New	ADVAXIS INC	$51,000	–	5,000	–	0.05%	–
GLMD	New	GALMED PHARMACEUTICALS LTD	$44,000	–	5,871	–	0.04%	–
TTHI	Exit	TRANSITION THERAPEUTICS INC	$0	–	-59,222	–	-0.10%	–
CLBS	Exit	CALADRIUS BIOSCIENCES INC	$0	–	-88,900	–	-0.14%	–
BITI	Exit	BIOTIE THERAPIESadr	$0	–	-10,000	–	-0.17%	–
PIRS	Exit	PIERIS PHARMACEUTICALS INC	$0	–	-125,000	–	-0.29%	–
AFMD	Exit	AFFIMED THERAPEUTICS BV	$0	–	-28,950	–	-0.33%	–
RTIX	Exit	RTI SURGICAL INC	$0	–	-85,918	–	-0.47%	–
ECIA	Exit	ENCISION INC	$0	–	-1,062,500	–	-0.49%	–
ABIO	Exit	ARCA BIOPHARMA INC	$0	–	-567,859	–	-0.55%	–
TRGT	Exit	TARGACEPT INC	$0	–	-463,914	–	-1.09%	–
NEOT	Exit	NEOTHETICS INC	$0	–	-184,187	–	-1.40%	–
CLVS	Exit	CLOVIS ONCOLOGY INC	$0	–	-23,090	–	-1.72%	–

Q2 2015

			Value		Shares		↓ Weighting
ATRC	New	ATRICURE INC	$13,518,000	–	548,611	–	11.43%	–
ABBV	New	ABBVIE INC	$7,833,000	–	116,581	–	6.62%	–
NXTM	New	NXSTAGE MEDICAL INC	$5,236,000	–	366,554	–	4.43%	–
ACHN	New	ACHILLION PHARMACEUTICALS	$4,255,000	–	480,300	–	3.60%	–
RIGL	New	RIGEL PHARMACEUTICALS INC	$3,562,000	–	1,109,740	–	3.01%	–
ZSPH	New	ZS PHARMA INC	$3,515,000	–	67,100	–	2.97%	–
BCRX	New	BIOCRYST PHARMACEUTICALS INC	$3,309,000	–	221,656	–	2.80%	–
PODD	New	INSULET CORP	$3,285,000	–	106,018	–	2.78%	–
DSCO	New	DISCOVERY LABORATORIES INC	$3,261,000	–	4,794,874	–	2.76%	–
XNPT	New	XENOPORT INC	$3,255,000	–	531,032	–	2.75%	–
	New	PROTALIX BIOTHERAPEUTICS INCnote 4.500% 9/1	$3,196,000	–	4,000,000	–	2.70%	–
AERI	New	AERIE PHARMACEUTICALS INC	$2,768,000	–	156,842	–	2.34%	–
DSCI	New	DERMA SCIENCES INC	$2,677,000	–	373,918	–	2.26%	–
SGYPQ	New	SYNERGY PHARMACEUTICALS	$2,636,000	–	317,563	–	2.23%	–
	New	ESSA PHARMA INC	$2,626,000	–	231,200	–	2.22%	–
OTIC	New	OTONOMY INC	$2,563,000	–	111,466	–	2.17%	–
AGTC	New	APPLIED GENETIC TECHNOL CORP	$2,411,000	–	157,192	–	2.04%	–
PLX	New	PROTALIX BIOTHERAPEUTICS INC	$2,400,000	–	1,230,789	–	2.03%	–
	New	INSULET CORPnote 2.000% 6/1	$2,338,000	–	2,407,000	–	1.98%	–
BEAT	New	BIOTELEMETRY INC	$2,222,000	–	235,645	–	1.88%	–
CLVS	New	CLOVIS ONCOLOGY INC	$2,029,000	–	23,090	–	1.72%	–
STXS	New	STEREOTAXIS INC	$1,977,000	–	1,372,862	–	1.67%	–
MASI	New	MASIMO CORPORATION	$1,782,000	–	46,010	–	1.51%	–
CYNA	New	CYNAPSUS THERAPEUTICS INC	$1,730,000	–	94,824	–	1.46%	–
NEOT	New	NEOTHETICS INC	$1,658,000	–	184,187	–	1.40%	–
ASND	New	ASCENDIS PHARMAadr added	$1,654,000	–	93,541	–	1.40%	–
CYAD	New	CELYADadr	$1,561,000	–	30,000	–	1.32%	–
CARA	New	CARA THERAPEUTICS INC	$1,543,000	–	126,956	–	1.30%	–
ZGNX	New	ZOGENIX INC	$1,434,000	–	853,700	–	1.21%	–
SCYX	New	SCYNEXIS INC	$1,419,000	–	161,382	–	1.20%	–
TRGT	New	TARGACEPT INC	$1,294,000	–	463,914	–	1.09%	–
NVDQ	New	NOVADAQ TECHNOLOGIES INC	$1,233,000	–	101,841	–	1.04%	–
DRNA	New	DICERNA PHARMACEUTICALS INC	$1,211,000	–	86,800	–	1.02%	–
CYTR	New	CYTRX CORP	$1,119,000	–	300,813	–	0.95%	–
QURE	New	UNIQURE B.V.	$1,080,000	–	40,000	–	0.91%	–
BLUE	New	BLUEBIRD BIO INC	$1,010,000	–	6,000	–	0.85%	–
DERM	New	DERMIRA INC	$996,000	–	56,736	–	0.84%	–
	New	NUVASIVE INCnote 2.750% 7/0	$968,000	–	760,000	–	0.82%	–
ELOS	New	SYNERON MEDICAL LTD	$966,000	–	90,947	–	0.82%	–
CDNA	New	CAREDX INC	$947,000	–	145,627	–	0.80%	–
SPNC	New	SPECTRANETICS CORP	$916,000	–	39,812	–	0.78%	–
JNJ	New	JOHNSON AND JOHNSON	$916,000	–	9,400	–	0.78%	–
ARNA	New	ARENA PHARMACEUTICALS INC	$877,000	–	189,000	–	0.74%	–
CRDC	New	CARDICA INC	$742,000	–	1,486,004	–	0.63%	–
LPCN	New	LIPOCINE INC	$729,000	–	85,000	–	0.62%	–
EXAC	New	EXACTECH INC	$659,000	–	31,636	–	0.56%	–
ABIO	New	ARCA BIOPHARMA INC	$653,000	–	567,859	–	0.55%	–
ECIA	New	ENCISION INC	$584,000	–	1,062,500	–	0.49%	–
CGNT	New	COGENTIX MEDICAL INC	$572,000	–	353,181	–	0.48%	–
	New	CYNAPSUS THERAPEUTICS INC	$559,000	–	33,995	–	0.47%	–
RTIX	New	RTI SURGICAL INC	$555,000	–	85,918	–	0.47%	–
ICPT	New	INTERCEPT PHARMACEUTICALS IN	$483,000	–	2,000	–	0.41%	–
LMNS	New	LUMENIS LTD	$426,000	–	31,072	–	0.36%	–
	New	IRONWOOD PHARMAnote 2.25% 15-jun-2022 144a sr unsecured conv	$396,000	–	400,000	–	0.34%	–
TNDM	New	TANDEM DIABETES CARE INC	$390,000	–	35,992	–	0.33%	–
AFMD	New	AFFIMED THERAPEUTICS BV	$390,000	–	28,950	–	0.33%	–
CHEK	New	CHECK CAP LTD	$385,000	–	110,000	–	0.33%	–
	New	APTOSE BIOSCIENCES INC	$359,000	–	70,396	–	0.30%	–
PIRS	New	PIERIS PHARMACEUTICALS INC	$344,000	–	125,000	–	0.29%	–
APPY	New	VENAXIS INC	$295,000	–	658,000	–	0.25%	–
MRNS	New	MARINUS PHARMACEUTICALS INC	$259,000	–	22,319	–	0.22%	–
ATNM	New	ACTINIUM PHARMACEUTICALS INC	$239,000	–	90,000	–	0.20%	–
NVLS	New	NIVALIS THERAPEUTICS INC	$227,000	–	15,000	–	0.19%	–
LOXO	New	LOXO ONCOLOGY INC	$221,000	–	12,245	–	0.19%	–
CVM	New	CEL SCI CORP	$209,000	–	316,500	–	0.18%	–
GNVC	New	GENVEC INC	$204,000	–	100,000	–	0.17%	–
BITI	New	BIOTIE THERAPIESadr	$200,000	–	10,000	–	0.17%	–
CLBS	New	CALADRIUS BIOSCIENCES INC	$166,000	–	88,900	–	0.14%	–
ONTY	New	ONCOTHYREON INC	$135,000	–	36,180	–	0.11%	–
CEMI	New	CHEMBIO DIAGNOSTICS INC	$129,000	–	26,287	–	0.11%	–
TTHI	New	TRANSITION THERAPEUTICS INC	$124,000	–	59,222	–	0.10%	–
CRBP	New	CORBUS PHARMACEUTICALS HLDGS	$113,000	–	36,590	–	0.10%	–
CASM	New	CAS MEDICAL SYSTEMS INC	$113,000	–	88,522	–	0.10%	–
CHEKW	New	CHECK CAP LTD*w exp 02/28/202 added	$96,000	–	55,000	–	0.08%	–
ATRS	New	ANTARES PHARMA INC	$94,000	–	45,000	–	0.08%	–

Q4 2014

			Value		Shares		↓ Weighting
RVP	Exit	RETRACTABLE TECHNOLOGIES INC	$0	–	-20,000	–	-0.06%	–
GBIM	Exit	GLOBEIMMUNE INC	$0	–	-10,745	–	-0.08%	–
NSPR	Exit	INSPIREMD INC	$0	–	-63,700	–	-0.14%	–
	Exit	CYNAPSUS THERAPEUTICS INC COM ACCD INVS	$0	–	-280,769	–	-0.15%	–
TNXP	Exit	TONIX PHARMACEUTICALS HLDG C	$0	–	-25,000	–	-0.17%	–
CEMI	Exit	CHEMBIO DIAGNOSTICS INC	$0	–	-55,202	–	-0.21%	–
GNVC	Exit	GENVEC INC	$0	–	-100,000	–	-0.21%	–
CRIS	Exit	CURIS INC	$0	–	-150,000	–	-0.21%	–
IPCI	Exit	INTELLIPHARMACEUTICS INTERNA	$0	–	-72,787	–	-0.22%	–
BLFS	Exit	BIOLIFE SOLUTIONS INC	$0	–	-116,279	–	-0.25%	–
ACHN	Exit	ACHILLION PHARMACEUTICALS	$0	–	-26,000	–	-0.26%	–
LMNS	Exit	LUMENIS LTD	$0	–	-29,018	–	-0.26%	–
CLTX	Exit	CELSUS THERAPEUTICS PLCsponsored adr ne	$0	–	-43,900	–	-0.27%	–
QURE	Exit	UNIQURE	$0	–	-32,000	–	-0.30%	–
TRGT	Exit	TARGACEPT INC	$0	–	-133,972	–	-0.34%	–
LPTN	Exit	LPATH INC	$0	–	-102,798	–	-0.36%	–
SCYX	Exit	SCYNEXIS INC	$0	–	-50,000	–	-0.37%	–
MASI	Exit	MASIMO CORPORATION	$0	–	-17,500	–	-0.38%	–
FATE	Exit	FATE THERAPEUTICS INC	$0	–	-75,930	–	-0.39%	–
RTIX	Exit	RTI SURGICAL INC	$0	–	-85,918	–	-0.42%	–
ONTY	Exit	ONCOTHYREON INC	$0	–	-214,972	–	-0.42%	–
ICPT	Exit	INTERCEPT PHARMACEUTICALS IN	$0	–	-2,000	–	-0.48%	–
CDNA	Exit	CAREDX INC	$0	–	-75,000	–	-0.53%	–
AMPE	Exit	AMPIO PHARMACEUTICALS INC	$0	–	-150,000	–	-0.54%	–
CYTR	Exit	CYTRX CORP	$0	–	-225,000	–	-0.58%	–
ASTM	Exit	AASTROM BIOSCIENCES INC	$0	–	-238,900	–	-0.69%	–
EXAC	Exit	EXACTECH INC	$0	–	-31,636	–	-0.73%	–
BCRX	Exit	BIOCRYST PHARMACEUTICALS INC	$0	–	-76,400	–	-0.75%	–
AFMD	Exit	AFFIMED THERAPEUTICS BV	$0	–	-120,000	–	-0.76%	–
CUTR	Exit	CUTERA INC	$0	–	-88,694	–	-0.90%	–
BLUE	Exit	BLUEBIRD BIO INC	$0	–	-25,000	–	-0.90%	–
ELOS	Exit	SYNERON MEDICAL LTD	$0	–	-90,947	–	-0.92%	–
ECIA	Exit	ENCISION INC	$0	–	-1,062,500	–	-0.99%	–
JNJ	Exit	JOHNSON AND JOHNSON	$0	–	-9,400	–	-1.01%	–
GLMD	Exit	GALMED PHARMACEUTICALS LTD	$0	–	-116,987	–	-1.02%	–
NBIX	Exit	NEUROCRINE BIOSCIENCES INC	$0	–	-66,141	–	-1.04%	–
APPY	Exit	VENAXIS INC	$0	–	-658,000	–	-1.10%	–
SPNC	Exit	SPECTRANETICS CORP	$0	–	-42,162	–	-1.13%	–
	Exit	NUVASIVE INCnote 2.750% 7/0	$0	–	-1,000,000	–	-1.16%	–
UPI	Exit	UROPLASTY INC	$0	–	-486,062	–	-1.22%	–
XNPT	Exit	XENOPORT INC	$0	–	-240,190	–	-1.30%	–
BEAT	Exit	BIOTELEMETRY INC	$0	–	-235,645	–	-1.60%	–
CRDC	Exit	CARDICA INC	$0	–	-1,486,004	–	-1.60%	–
CLVS	Exit	CLOVIS ONCOLOGY INC	$0	–	-36,900	–	-1.69%	–
THLD	Exit	THRESHOLD PHARMACEUTICALS	$0	–	-555,965	–	-2.02%	–
BSTC	Exit	BIOSPECIFICS TECHNOLOGIES	$0	–	-60,054	–	-2.14%	–
	Exit	INSULET CORPnote 2.000% 6/1	$0	–	-2,407,000	–	-2.70%	–
AERI	Exit	AERIE PHARMACEUTICALS INC	$0	–	-145,342	–	-3.03%	–
PLX	Exit	PROTALIX BIOTHERAPEUTICS INC	$0	–	-1,288,440	–	-3.14%	–
STXS	Exit	STEREOTAXIS INC	$0	–	-1,374,975	–	-3.22%	–
DSCI	Exit	DERMA SCIENCES INC	$0	–	-384,794	–	-3.23%	–
OCRX	Exit	OCERA THERAPEUTICS INC	$0	–	-675,650	–	-3.34%	–
NVDQ	Exit	NOVADAQ TECHNOLOGIES INC	$0	–	-263,541	–	-3.37%	–
ASPX	Exit	AUSPEX PHARMACEUTICALS INC	$0	–	-152,002	–	-3.94%	–
PODD	Exit	INSULET CORP	$0	–	-109,418	–	-4.07%	–
NXTM	Exit	NXSTAGE MEDICAL INC	$0	–	-384,154	–	-5.09%	–
ATRC	Exit	ATRICURE INC	$0	–	-598,883	–	-8.89%	–
DSCO	Exit	DISCOVERY LABORATORIES INC	$0	–	-5,698,739	–	-10.58%	–
PCYC	Exit	PHARMACYCLICS INC	$0	–	-110,928	–	-13.14%	–

Q3 2014

			Value		Shares		↓ Weighting
PCYC	Sell	PHARMACYCLICS INC	$13,026,000	+25.6%	110,928	-4.1%	13.14%	+33.6%
ATRC	Buy	ATRICURE INC	$8,816,000	-16.0%	598,883	+4.9%	8.89%	-10.6%
ASPX	New	AUSPEX PHARMACEUTICALS INC	$3,902,000	–	152,002	–	3.94%	–
OCRX	Buy	OCERA THERAPEUTICS INC	$3,311,000	+169.8%	675,650	+320.6%	3.34%	+187.1%
STXS	Sell	STEREOTAXIS INC	$3,190,000	-35.0%	1,374,975	-0.5%	3.22%	-30.8%
PLX	Buy	PROTALIX BIOTHERAPEUTICS INC	$3,118,000	-27.5%	1,288,440	+9.3%	3.14%	-22.8%
AERI	New	AERIE PHARMACEUTICALS INC	$3,007,000	–	145,342	–	3.03%	–
BSTC	Sell	BIOSPECIFICS TECHNOLOGIES	$2,120,000	+12.2%	60,054	-14.3%	2.14%	+19.4%
THLD	Buy	THRESHOLD PHARMACEUTICALS	$2,007,000	+29.0%	555,965	+41.5%	2.02%	+37.2%
CLVS	New	CLOVIS ONCOLOGY INC	$1,674,000	–	36,900	–	1.69%	–
UPI	Buy	UROPLASTY INC	$1,215,000	+2.6%	486,062	+10.0%	1.22%	+9.2%
NBIX	New	NEUROCRINE BIOSCIENCES INC	$1,036,000	–	66,141	–	1.04%	–
GLMD	Sell	GALMED PHARMACEUTICALS LTD	$1,006,000	-49.9%	116,987	-43.2%	1.02%	-46.6%
BLUE	New	BLUEBIRD BIO INC	$897,000	–	25,000	–	0.90%	–
AFMD	New	AFFIMED THERAPEUTICS BV	$756,000	–	120,000	–	0.76%	–
BCRX	New	BIOCRYST PHARMACEUTICALS INC	$747,000	–	76,400	–	0.75%	–
ASTM	New	AASTROM BIOSCIENCES INC	$681,000	–	238,900	–	0.69%	–
AMPE	Sell	AMPIO PHARMACEUTICALS INC	$530,000	-95.5%	150,000	-89.3%	0.54%	-95.2%
CDNA	New	CAREDX INC	$525,000	–	75,000	–	0.53%	–
ONTY	New	ONCOTHYREON INC	$413,000	–	214,972	–	0.42%	–
RTIX	Sell	RTI SURGICAL INC	$411,000	-43.5%	85,918	-48.6%	0.42%	-39.8%
LPTN	Sell	LPATH INC	$362,000	-13.2%	102,798	-2.1%	0.36%	-7.6%
TRGT	New	TARGACEPT INC	$339,000	–	133,972	–	0.34%	–
QURE	New	UNIQURE	$296,000	–	32,000	–	0.30%	–
ACHN	New	ACHILLION PHARMACEUTICALS	$259,000	–	26,000	–	0.26%	–
LMNS	Buy	LUMENIS LTD	$259,000	+181.5%	29,018	+206.2%	0.26%	+200.0%
IPCI	New	INTELLIPHARMACEUTICS INTERNA	$219,000	–	72,787	–	0.22%	–
	New	CYNAPSUS THERAPEUTICS INC COM ACCD INVS	$149,000	–	280,769	–	0.15%	–
NSPR	Sell	INSPIREMD INC	$140,000	-43.5%	63,700	-24.4%	0.14%	-40.0%
GBIM	New	GLOBEIMMUNE INC	$74,000	–	10,745	–	0.08%	–
NWBO	Exit	NORTHWEST BIOTHERAPEUTICS IN	$0	–	-12,017	–	-0.08%	–
RGDO	Exit	REGADO BIOSCIENCES INC	$0	–	-30,000	–	-0.19%	–
ARDX	Exit	ARDELYX INC	$0	–	-25,000	–	-0.38%	–
KERX	Exit	KERYX BIOPHARMACEUTICALS	$0	–	-92,400	–	-1.35%	–
ADHD	Exit	ALCOBRA LTD	$0	–	-84,996	–	-1.39%	–
BOTA	Exit	BIOTA PHARMACEUTICALS INC	$0	–	-729,781	–	-1.97%	–

Q2 2014

			Value		Shares		↓ Weighting
AMPE	New	AMPIO PHARMACEUTICALS INC	$11,700,000	–	1,401,146	–	11.09%	–
ATRC	New	ATRICURE INC	$10,495,000	–	570,987	–	9.95%	–
PCYC	New	PHARMACYCLICS INC	$10,373,000	–	115,628	–	9.83%	–
DSCO	New	DISCOVERY LABORATORIES INC	$10,144,000	–	5,698,739	–	9.61%	–
NXTM	New	NXSTAGE MEDICAL INC	$5,520,000	–	384,154	–	5.23%	–
STXS	New	STEREOTAXIS INC	$4,904,000	–	1,381,460	–	4.65%	–
DSCI	New	DERMA SCIENCES INC	$4,448,000	–	384,794	–	4.22%	–
NVDQ	New	NOVADAQ TECHNOLOGIES INC	$4,343,000	–	263,541	–	4.12%	–
PODD	New	INSULET CORP	$4,341,000	–	109,418	–	4.11%	–
PLX	New	PROTALIX BIOTHERAPEUTICS INC	$4,301,000	–	1,178,440	–	4.08%	–
	New	INSULET CORPnote 2.000% 6/1	$2,675,000	–	2,407,000	–	2.54%	–
BOTA	New	BIOTA PHARMACEUTICALS INC	$2,080,000	–	729,781	–	1.97%	–
GLMD	New	GALMED PHARMACEUTICALS LTD	$2,007,000	–	206,100	–	1.90%	–
BSTC	New	BIOSPECIFICS TECHNOLOGIES	$1,890,000	–	70,088	–	1.79%	–
CRDC	New	CARDICA INC	$1,694,000	–	1,486,004	–	1.60%	–
BEAT	New	BIOTELEMETRY INC	$1,690,000	–	235,645	–	1.60%	–
THLD	New	THRESHOLD PHARMACEUTICAL INC	$1,556,000	–	393,000	–	1.48%	–
ADHD	New	ALCOBRA LTD	$1,471,000	–	84,996	–	1.39%	–
APPY	New	VENAXIS INC	$1,467,000	–	658,000	–	1.39%	–
KERX	New	KERYX BIOPHARMACEUTICALS	$1,421,000	–	92,400	–	1.35%	–
OCRX	New	OCERA THERAPEUTICS INC	$1,227,000	–	160,622	–	1.16%	–
UPI	New	UROPLASTY INC	$1,184,000	–	441,859	–	1.12%	–
XNPT	New	XENOPORT INC	$1,160,000	–	240,190	–	1.10%	–
	New	NUVASIVE INCnote 2.750% 7/0	$1,146,000	–	1,000,000	–	1.09%	–
ECIA	New	ENCISION INC	$1,126,000	–	1,062,500	–	1.07%	–
JNJ	New	JOHNSON AND JOHNSON	$983,000	–	9,400	–	0.93%	–
SPNC	New	SPECTRANETICS CORP	$965,000	–	42,162	–	0.92%	–
CYTR	New	CYTRX CORP	$941,000	–	225,000	–	0.89%	–
ELOS	New	SYNERON MEDICAL LTD	$939,000	–	90,947	–	0.89%	–
CUTR	New	CUTERA INC	$922,000	–	88,694	–	0.87%	–
EXAC	New	EXACTECH INC	$798,000	–	31,636	–	0.76%	–
RTIX	New	RTI SURGICAL INC	$727,000	–	167,058	–	0.69%	–
FATE	New	FATE THERAPEUTICS INC	$479,000	–	75,930	–	0.45%	–
ICPT	New	INTERCEPT PHARMACEUTICALS IN	$473,000	–	2,000	–	0.45%	–
LPTN	New	LPATH INC	$417,000	–	105,000	–	0.40%	–
MASI	New	MASIMO CORPORATION	$413,000	–	17,500	–	0.39%	–
SCYX	New	SCYNEXIS INC	$401,000	–	50,000	–	0.38%	–
ARDX	New	ARDELYX INC	$399,000	–	25,000	–	0.38%	–
TNXP	New	TONIX PHARMACEUTICALS HLDG C	$359,000	–	25,000	–	0.34%	–
CRIS	New	CURIS INC	$279,000	–	150,000	–	0.26%	–
CLTX	New	CELSUS THERAPEUTICS PLCsponsored adr ne	$272,000	–	43,900	–	0.26%	–
BLFS	New	BIOLIFE SOLUTIONS INC	$265,000	–	116,279	–	0.25%	–
GNVC	New	GENVEC INC	$257,000	–	100,000	–	0.24%	–
NSPR	New	INSPIREMD INC	$248,000	–	84,226	–	0.24%	–
RGDO	New	REGADO BIOSCIENCES INC	$204,000	–	30,000	–	0.19%	–
CEMI	New	CHEMBIO DIAGNOSTICS INC	$189,000	–	55,202	–	0.18%	–
LMNS	New	LUMENIS LTD	$92,000	–	9,478	–	0.09%	–
NWBO	New	NORTHWEST BIOTHERAPEUTICS IN	$81,000	–	12,017	–	0.08%	–
RVP	New	RETRACTABLE TECHNOLOGIES INC	$50,000	–	20,000	–	0.05%	–

Q4 2013

			Value		Shares		↓ Weighting
CBMXW	Exit	COMBIMATRIX CORP*w exp 05/01/201	$0	–	-2,325	–	-0.00%	–
OCRX	Exit	OCERA THERAPEUTICS INC	$0	–	-7,894	–	-0.07%	–
ADAT	Exit	AUTHENTIDATE HOLDING CORP	$0	–	-142,062	–	-0.14%	–
TNXP	Exit	TONIX PHARMACEUTICALS HOLDIN	$0	–	-45,000	–	-0.18%	–
BIOL	Exit	BIOLASE INC	$0	–	-111,604	–	-0.23%	–
PTN	Exit	PALATIN TECHNOLOGIES INC	$0	–	-374,490	–	-0.28%	–
GRMH	Exit	GRAYMARK HEALTHCARE INC	$0	–	-693,027	–	-0.31%	–
IDRA	Exit	IDERA PHARMACEUTICALS INC	$0	–	-200,000	–	-0.38%	–
TGX	Exit	THERAGENICS CORP	$0	–	-160,719	–	-0.38%	–
ACHN	Exit	ACHILLION PHARMACEUTICALS	$0	–	-121,800	–	-0.40%	–
TGTX	Exit	TG THERAPEUTICS INC	$0	–	-75,000	–	-0.41%	–
MASI	Exit	MASIMO CORPORATION	$0	–	-17,500	–	-0.51%	–
BAXSQ	Exit	BAXANO SURGICAL INC	$0	–	-336,351	–	-0.51%	–
DYAX	Exit	DYAX CORP	$0	–	-75,500	–	-0.57%	–
RTIX	Exit	RTI SURGICAL INC	$0	–	-167,058	–	-0.68%	–
NVAX	Exit	NOVAVAX INC	$0	–	-210,000	–	-0.72%	–
ICPT	Exit	INTERCEPT PHARMACEUTICALS IN	$0	–	-9,598	–	-0.72%	–
EXAC	Exit	EXACTECH INC	$0	–	-33,636	–	-0.74%	–
MACK	Exit	MERRIMACK PHARMACEUTICALS IN	$0	–	-181,153	–	-0.75%	–
DSCI	Exit	DERMA SCIENCES INC	$0	–	-57,009	–	-0.77%	–
KERX	Exit	KERYX BIOPHARMACEUTICALS	$0	–	-74,100	–	-0.82%	–
ELOS	Exit	SYNERON MEDICAL LTD	$0	–	-90,947	–	-0.86%	–
CUTR	Exit	CUTERA INC	$0	–	-88,694	–	-0.86%	–
JNJ	Exit	JOHNSON AND JOHNSON	$0	–	-9,400	–	-0.89%	–
BOTA	Exit	BIOTA PHARMACEUTICALS INC	$0	–	-202,157	–	-0.92%	–
CUR	Exit	NEURALSTEM INC	$0	–	-312,500	–	-0.92%	–
GALE	Exit	GALENA BIOPHARMA INC	$0	–	-375,000	–	-0.93%	–
SPNC	Exit	SPECTRANETICS CORP	$0	–	-52,362	–	-0.96%	–
UPI	Exit	UROPLASTY INC	$0	–	-289,332	–	-1.05%	–
	Exit	NUVASIVE INCnote 2.750% 7/0	$0	–	-1,000,000	–	-1.06%	–
BSTC	Exit	BIOSPECIFICS TECHNOLOGIES	$0	–	-51,692	–	-1.10%	–
XNPT	Exit	XENOPORT INC	$0	–	-191,262	–	-1.19%	–
KBIO	Exit	KALOBIOS PHARMACEUTICALS INC	$0	–	-250,000	–	-1.23%	–
APPY	Exit	VENAXIS INC	$0	–	-590,000	–	-1.25%	–
CNAT	Exit	CONATUS PHARMACEUTICALS INC	$0	–	-115,620	–	-1.27%	–
	Exit	WRIGHT MED GROUP INCnote 2.000% 8/1	$0	–	-1,000,000	–	-1.34%	–
CRDC	Exit	CARDICA INC	$0	–	-1,063,469	–	-1.51%	–
NSPR	Exit	INSPIREMD INC	$0	–	-715,200	–	-1.82%	–
CRIS	Exit	CURIS INC	$0	–	-529,896	–	-2.58%	–
ARIA	Exit	ARIAD PHARMACEUTICALS INC	$0	–	-148,915	–	-2.99%	–
GIVN	Exit	GIVEN IMAGING LTD	$0	–	-156,320	–	-3.28%	–
BEAT	Exit	BIOTELEMETRY INC	$0	–	-308,565	–	-3.34%	–
AMPE	Exit	AMPIO PHARMACEUTICALS INC	$0	–	-425,703	–	-3.49%	–
NXTM	Exit	NXSTAGE MEDICAL INC	$0	–	-251,654	–	-3.62%	–
DSCO	Exit	DISCOVERY LABORATORIES INC	$0	–	-2,025,646	–	-4.34%	–
	Exit	INSULET CORPnote 3.750% 6/1	$0	–	-3,000,000	–	-4.75%	–
PODD	Exit	INSULET CORP	$0	–	-124,981	–	-4.95%	–
NVDQ	Exit	NOVADAQ TECHNOLOGIES INC	$0	–	-284,041	–	-5.14%	–
ATRC	Exit	ATRICURE INC	$0	–	-477,701	–	-5.73%	–
STXS	Exit	STEREOTAXIS INC	$0	–	-1,585,332	–	-5.77%	–
PLX	Exit	PROTALIX BIOTHERAPEUTICS INC	$0	–	-1,178,440	–	-5.83%	–
PCYC	Exit	PHARMACYCLICS INC	$0	–	-102,128	–	-15.42%	–

Q3 2013

			Value		Shares		↓ Weighting
PLX	Buy	PROTALIX BIOTHERAPEUTICS INC	$5,338,000	+25.2%	1,178,440	+35.7%	5.83%	-6.5%
STXS	Buy	STEREOTAXIS INC	$5,279,000	+1439.1%	1,585,332	+615.7%	5.77%	+1048.8%
NVDQ	Sell	NOVADAQ TECHNOLOGIES INC	$4,709,000	-24.2%	284,041	-38.4%	5.14%	-43.4%
DSCO	Buy	DISCOVERY LABORATORIES INC	$3,970,000	+50.7%	2,025,646	+16.8%	4.34%	+12.4%
AMPE	New	AMPIO PHARMACEUTICALS INC	$3,193,000	–	425,703	–	3.49%	–
BEAT	New	BIOTELEMETRY INC	$3,058,000	–	308,565	–	3.34%	–
ARIA	Sell	ARIAD PHARMACEUTICALS INC	$2,740,000	-18.1%	148,915	-22.1%	2.99%	-38.8%
CRIS	Sell	CURIS INC	$2,363,000	+34.7%	529,896	-3.6%	2.58%	+0.5%
	New	WRIGHT MED GROUP INCnote 2.000% 8/1	$1,229,000	–	1,000,000	–	1.34%	–
CNAT	New	CONATUS PHARMACEUTICALS INC	$1,162,000	–	115,620	–	1.27%	–
APPY	Sell	VENAXIS INC	$1,145,000	+37.0%	590,000	-15.4%	1.25%	+2.2%
KBIO	Buy	KALOBIOS PHARMACEUTICALS INC	$1,130,000	+150.0%	250,000	+213.1%	1.23%	+86.4%
GALE	New	GALENA BIOPHARMA INC	$855,000	–	375,000	–	0.93%	–
CUR	New	NEURALSTEM INC	$847,000	–	312,500	–	0.92%	–
BOTA	New	BIOTA PHARMACEUTICALS INC	$845,000	–	202,157	–	0.92%	–
KERX	Sell	KERYX BIOPHARMACEUTICALS	$748,000	+30.1%	74,100	-3.8%	0.82%	-3.0%
MACK	New	MERRIMACK PHARMACEUTICALS IN	$687,000	–	181,153	–	0.75%	–
ICPT	Sell	INTERCEPT PHARMACEUTICALS IN	$663,000	+48.0%	9,598	-4.0%	0.72%	+10.4%
NVAX	New	NOVAVAX INC	$662,000	–	210,000	–	0.72%	–
DYAX	Sell	DYAX CORP	$518,000	-74.1%	75,500	-86.9%	0.57%	-80.7%
TGTX	New	TG THERAPEUTICS INC	$378,000	–	75,000	–	0.41%	–
IDRA	New	IDERA PHARMACEUTICALS INC	$348,000	–	200,000	–	0.38%	–
PTN	Sell	PALATIN TECHNOLOGIES INC	$258,000	-19.1%	374,490	-27.3%	0.28%	-39.6%
BIOL	New	BIOLASE INC	$213,000	–	111,604	–	0.23%	–
TNXP	New	TONIX PHARMACEUTICALS HOLDIN	$164,000	–	45,000	–	0.18%	–
OCRX	New	OCERA THERAPEUTICS INC	$67,000	–	7,894	–	0.07%	–
DRAD	Exit	DIGIRAD CORP	$0	–	-36,672	–	-0.13%	–
CYCC	Exit	CYCLACEL PHARMACEUTICALS INC	$0	–	-44,300	–	-0.19%	–
ANAC	Exit	ANACOR PHARMACEUTICALS INC	$0	–	-106,993	–	-0.88%	–
VRTX	Exit	VERTEX PHARMACEUTICALS INC	$0	–	-8,600	–	-1.01%	–
INFU	Exit	INFUSYSTEM HOLDINGS INC	$0	–	-474,484	–	-1.04%	–
BEAT	Exit	CARDIONET INC	$0	–	-401,788	–	-3.47%	–

Q2 2013

			Value		Shares		↓ Weighting
PCYC	New	PHARMACYCLICS INC	$8,116,000	–	102,128	–	11.88%	–
NVDQ	New	NOVADAQ TECHNOLOGIES INC	$6,210,000	–	461,362	–	9.09%	–
ATRC	New	ATRICURE INC	$4,538,000	–	477,701	–	6.64%	–
PLX	New	PROTALIX BIOTHERAPEUTICS INC	$4,262,000	–	868,106	–	6.24%	–
PODD	New	INSULET CORP	$3,926,000	–	124,981	–	5.75%	–
	New	INSULET CORPnote 3.750% 6/1	$3,911,000	–	3,000,000	–	5.72%	–
NXTM	New	NXSTAGE MEDICAL INC	$3,594,000	–	251,654	–	5.26%	–
ARIA	New	ARIAD PHARMACEUTICALS INC	$3,344,000	–	191,215	–	4.89%	–
DSCO	New	DISCOVERY LABORATORIES INC	$2,635,000	–	1,733,660	–	3.86%	–
BEAT	New	CARDIONET INC	$2,371,000	–	401,788	–	3.47%	–
GIVN	New	GIVEN IMAGING LTD	$2,190,000	–	156,320	–	3.20%	–
DYAX	New	DYAX CORP	$2,001,000	–	578,381	–	2.93%	–
CRIS	New	CURIS INC	$1,754,000	–	549,896	–	2.57%	–
NSPR	New	INSPIREMD INC	$1,581,000	–	715,200	–	2.31%	–
CRDC	New	CARDICA INC	$1,180,000	–	1,063,469	–	1.73%	–
ACHN	New	ACHILLION PHARMACEUTICALS	$996,000	–	121,800	–	1.46%	–
	New	NUVASIVE INCnote 2.750% 7/0	$986,000	–	1,000,000	–	1.44%	–
SPNC	New	SPECTRANETICS CORP	$978,000	–	52,362	–	1.43%	–
XNPT	New	XENOPORT INC	$947,000	–	191,262	–	1.39%	–
APPY	New	VENAXIS INC	$836,000	–	697,000	–	1.22%	–
JNJ	New	JOHNSON AND JOHNSON	$807,000	–	9,400	–	1.18%	–
BAXSQ	New	BAXANO SURGICAL INC	$807,000	–	336,351	–	1.18%	–
BSTC	New	BIOSPECIFICS TECHNOLOGIES	$806,000	–	51,692	–	1.18%	–
ELOS	New	SYNERON MEDICAL LTD	$791,000	–	90,947	–	1.16%	–
CUTR	New	CUTERA INC	$781,000	–	88,694	–	1.14%	–
DSCI	New	DERMA SCIENCES INC	$761,000	–	57,009	–	1.11%	–
INFU	New	INFUSYSTEM HOLDINGS INC	$707,000	–	474,484	–	1.04%	–
VRTX	New	VERTEX PHARMACEUTICALS INC	$689,000	–	8,600	–	1.01%	–
EXAC	New	EXACTECH INC	$664,000	–	33,636	–	0.97%	–
RTIX	New	RTI BIOLOGICS INC	$628,000	–	167,058	–	0.92%	–
UPI	New	UROPLASTY INC	$599,000	–	289,332	–	0.88%	–
ANAC	New	ANACOR PHARMACEUTICALS INC	$598,000	–	106,993	–	0.88%	–
KERX	New	KERYX BIOPHARMACEUTICALS	$575,000	–	77,000	–	0.84%	–
KBIO	New	KALOBIOS PHARMACEUTICALS INC	$452,000	–	79,834	–	0.66%	–
ICPT	New	INTERCEPT PHARMACEUTICALS IN	$448,000	–	10,000	–	0.66%	–
MASI	New	MASIMO CORPORATION	$371,000	–	17,500	–	0.54%	–
STXS	New	STEREOTAXIS INC	$343,000	–	221,508	–	0.50%	–
TGX	New	THERAGENICS CORP	$333,000	–	160,719	–	0.49%	–
PTN	New	PALATIN TECHNOLOGIES INC	$319,000	–	514,768	–	0.47%	–
GRMH	New	GRAYMARK HEALTHCARE INC	$146,000	–	693,027	–	0.21%	–
CYCC	New	CYCLACEL PHARMACEUTICALS INC	$131,000	–	44,300	–	0.19%	–
ADAT	New	AUTHENTIDATE HOLDING CORP	$124,000	–	142,062	–	0.18%	–
DRAD	New	DIGIRAD CORP	$89,000	–	36,672	–	0.13%	–
CBMXW	New	COMBIMATRIX CORP*w exp 05/01/201	$1,000	–	2,325	–	0.00%	–

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