$2.34 Billion is the total value of Tekla Capital Management LLC's 203 reported holdings in Q4 2018. The portfolio turnover from Q3 2018 to Q4 2018 was 13.7% .
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| JNJ | Buy | Johnson & Johnson | $133,261,000 | -3.3% | 1,032,628 | +3.6% | 5.70% | +14.2% |
| AMGN | Amgen Inc. | $131,958,000 | -6.1% | 677,855 | 0.0% | 5.65% | +10.8% | |
| BIIB | Buy | Biogen Inc. | $118,834,000 | -14.1% | 394,902 | +0.9% | 5.09% | +1.4% |
| GILD | Sell | Gilead Sciences, Inc. | $118,210,000 | -21.2% | 1,889,846 | -2.7% | 5.06% | -7.0% |
| UNH | Buy | Unitedhealth Group Incorporated | $93,513,000 | +2.0% | 375,374 | +9.0% | 4.00% | +20.4% |
| CELG | Buy | Celgene Corporation | $88,573,000 | -24.6% | 1,382,006 | +5.3% | 3.79% | -11.0% |
| ILMN | Buy | Illumina, Inc. | $78,695,000 | -11.7% | 262,379 | +8.1% | 3.37% | +4.3% |
| VRTX | Buy | Vertex Pharmaceuticals Incorporated | $70,634,000 | -10.2% | 426,248 | +4.4% | 3.02% | +5.9% |
| PFE | Buy | Pfizer Inc. | $66,208,000 | +10.9% | 1,516,793 | +12.0% | 2.83% | +31.0% |
| MRK | Buy | Merck & Co., Inc. | $56,399,000 | +23.2% | 738,108 | +14.4% | 2.41% | +45.4% |
| REGN | Sell | Regeneron Pharmaceuticals, Inc. | $50,954,000 | -13.8% | 136,422 | -6.7% | 2.18% | +1.8% |
| ALXN | Buy | Alexion Pharmaceuticals, Inc. | $48,319,000 | -20.7% | 496,288 | +13.2% | 2.07% | -6.4% |
| ABBV | AbbVie Inc. | $45,365,000 | -2.5% | 492,078 | 0.0% | 1.94% | +15.0% | |
| MDT | Buy | Medtronic plcshares | $43,785,000 | +31.1% | 481,365 | +41.8% | 1.87% | +54.7% |
| TMO | Buy | Thermo Fisher Scientific Inc. | $42,944,000 | -2.5% | 191,895 | +6.4% | 1.84% | +15.1% |
| INCY | Incyte Corporation | $41,044,000 | -7.9% | 645,442 | 0.0% | 1.76% | +8.7% | |
| MYL | Sell | Mylan N.V.shares | $38,462,000 | -36.6% | 1,403,728 | -15.3% | 1.65% | -25.1% |
| ANTM | Anthem, Inc. | $37,069,000 | -4.2% | 141,147 | 0.0% | 1.59% | +13.1% | |
| BMY | Buy | Bristol-Myers Squibb Company | $33,941,000 | +49.4% | 652,966 | +78.4% | 1.45% | +76.3% |
| AGN | Sell | Allergan plcshares | $31,373,000 | -33.8% | 234,720 | -5.7% | 1.34% | -21.9% |
| CVS | Buy | CVS Health Corporation | $30,185,000 | -4.4% | 460,698 | +14.9% | 1.29% | +12.8% |
| ABT | Abbott Laboratories | $28,333,000 | -1.4% | 391,719 | 0.0% | 1.21% | +16.4% | |
| SYK | Stryker Corporation | $25,148,000 | -11.8% | 160,432 | 0.0% | 1.08% | +4.1% | |
| LLY | Eli Lilly and Company | $25,047,000 | +7.8% | 216,442 | 0.0% | 1.07% | +27.3% | |
| NVS | Sell | Novartis AGsponsored adr | $25,032,000 | -10.0% | 291,717 | -9.6% | 1.07% | +6.2% |
| DHR | Danaher Corporation | $21,590,000 | -5.1% | 209,371 | 0.0% | 0.92% | +12.0% | |
| ZTS | Buy | Zoetis Inc.class a | $21,506,000 | +3.3% | 251,415 | +10.6% | 0.92% | +22.0% |
| SRPT | Sell | Sarepta Therapeutics, Inc. | $20,935,000 | -41.9% | 191,837 | -14.0% | 0.90% | -31.4% |
| HUM | Humana Inc. | $19,620,000 | -15.4% | 68,487 | 0.0% | 0.84% | -0.1% | |
| CNC | Centene Corporation | $19,240,000 | -20.4% | 166,869 | 0.0% | 0.82% | -5.9% | |
| ISRG | Buy | Intuitive Surgical, Inc. | $18,788,000 | +32.9% | 39,229 | +59.3% | 0.80% | +56.7% |
| TEVA | Buy | Teva Pharmaceutical Industries Limitedsponsored adr | $18,687,000 | -7.0% | 1,211,868 | +29.9% | 0.80% | +9.7% |
| BMRN | Buy | BioMarin Pharmaceutical Inc. | $17,663,000 | +29.6% | 207,434 | +47.6% | 0.76% | +53.0% |
| AZN | Sell | AstraZeneca PLCsponsored adr | $16,256,000 | -42.8% | 428,024 | -40.4% | 0.70% | -32.5% |
| BSX | Boston Scientific Corporation | $15,726,000 | -8.2% | 444,991 | 0.0% | 0.67% | +8.4% | |
| BDX | Buy | Becton, Dickinson and Company | $15,722,000 | -6.1% | 69,778 | +8.7% | 0.67% | +10.9% |
| NBIX | Buy | Neurocrine Biosciences, Inc. | $15,446,000 | -40.9% | 216,294 | +1.7% | 0.66% | -30.3% |
| JAZZ | Buy | Jazz Pharmaceuticals plcshares | $14,279,000 | -23.1% | 115,187 | +4.3% | 0.61% | -9.2% |
| NVO | Novo Nordisk A/Sadr | $13,909,000 | -2.3% | 301,900 | 0.0% | 0.60% | +15.3% | |
| OHI | Sell | Omega Healthcare Investors, Inc. | $13,361,000 | -29.7% | 380,122 | -34.4% | 0.57% | -17.0% |
| SGEN | Sell | Seattle Genetics, Inc. | $12,819,000 | -40.5% | 226,239 | -19.0% | 0.55% | -29.8% |
| CI | New | Cigna Corporation | $12,172,000 | – | 64,089 | +100.0% | 0.52% | – |
| BGNE | BeiGene, Ltd.sponsored adr | $12,028,000 | -18.6% | 85,755 | 0.0% | 0.52% | -3.9% | |
| BAX | Buy | Baxter International Inc. | $10,612,000 | -5.7% | 161,233 | +10.4% | 0.45% | +11.3% |
| XBI | Buy | SPDR S&P Biotech ETFs&p biotech etf | $10,362,000 | -16.2% | 144,424 | +12.0% | 0.44% | -1.1% |
| FGEN | Buy | FibroGen, Inc. | $9,847,000 | -9.0% | 212,763 | +19.4% | 0.42% | +7.1% |
| BLUE | Buy | bluebird bio, Inc. | $9,764,000 | -23.8% | 98,429 | +12.1% | 0.42% | -10.1% |
| Aegerion Pharmaceuticals, Inc.note 2.00% 8/15/19 | $9,734,000 | -0.1% | 13,000,000 | 0.0% | 0.42% | +18.1% | ||
| IDXX | Sell | IDEXX Laboratories, Inc. | $9,594,000 | -62.5% | 51,575 | -49.6% | 0.41% | -55.7% |
| SAGE | Sell | Sage Therapeutics, Inc. | $9,430,000 | -53.5% | 98,444 | -31.5% | 0.40% | -45.1% |
| ZBH | Sell | Zimmer Biomet Holdings, Inc. | $9,252,000 | -40.8% | 89,204 | -24.9% | 0.40% | -30.2% |
| HCA | HCA Healthcare, Inc. | $9,251,000 | -10.5% | 74,335 | 0.0% | 0.40% | +5.6% | |
| ALNY | Alnylam Pharmaceuticals, Inc. | $9,199,000 | -16.7% | 126,176 | 0.0% | 0.39% | -1.5% | |
| GLPG | Galapagos NV | $9,157,000 | -18.4% | 99,815 | 0.0% | 0.39% | -3.7% | |
| SBRA | Sell | Sabra Health Care REIT, Inc. | $8,946,000 | -46.6% | 542,862 | -25.1% | 0.38% | -37.0% |
| AMRN | Sell | Amarin Corporation plcsponsored adr | $8,902,000 | -27.4% | 654,052 | -13.3% | 0.38% | -14.4% |
| EW | Sell | Edwards Lifesciences Corporation | $8,700,000 | -34.8% | 56,798 | -25.9% | 0.37% | -23.1% |
| MCK | Sell | McKesson Corporation | $8,696,000 | -21.0% | 78,720 | -5.1% | 0.37% | -6.8% |
| FOLD | Amicus Therapeutics, Inc. | $8,385,000 | -20.8% | 875,304 | 0.0% | 0.36% | -6.5% | |
| GSK | GlaxoSmithKline plcshares | $8,357,000 | -4.9% | 218,700 | 0.0% | 0.36% | +12.2% | |
| ABC | AmerisourceBergen Corporation | $8,318,000 | -19.3% | 111,807 | 0.0% | 0.36% | -4.8% | |
| MDCO | Buy | The Medicines Company | $8,211,000 | +65.5% | 428,992 | +158.7% | 0.35% | +95.0% |
| SNY | Sanofisponsored adr | $7,809,000 | -2.8% | 179,900 | 0.0% | 0.33% | +14.8% | |
| LTC | Sell | LTC Properties, Inc. | $7,445,000 | -19.5% | 178,623 | -14.8% | 0.32% | -4.8% |
| XLRN | Acceleron Pharma Inc. | $7,437,000 | -23.9% | 170,766 | 0.0% | 0.32% | -10.2% | |
| SNN | Smith & Nephew plcshares | $6,933,000 | +0.8% | 185,478 | 0.0% | 0.30% | +19.3% | |
| DPLO | Buy | Diplomat Pharmacy, Inc. | $6,807,000 | -20.1% | 505,701 | +15.2% | 0.29% | -5.8% |
| BPMC | Sell | Blueprint Medicines Corporation | $6,750,000 | -40.8% | 125,207 | -14.2% | 0.29% | -30.0% |
| RMD | ResMed Inc. | $6,676,000 | -1.3% | 58,630 | 0.0% | 0.29% | +16.7% | |
| EXEL | Sell | Exelixis, Inc. | $6,677,000 | -32.0% | 339,435 | -38.7% | 0.29% | -19.7% |
| MPW | Sell | Medical Properties Trust, Inc. | $6,654,000 | -6.5% | 413,809 | -13.3% | 0.28% | +10.5% |
| ESPR | Sell | Esperion Therapeutics, Inc. | $6,545,000 | -22.1% | 142,289 | -24.8% | 0.28% | -8.2% |
| PRAH | Buy | PRA Health Sciences, Inc. | $6,480,000 | +81.2% | 70,460 | +117.1% | 0.28% | +113.1% |
| SHPG | Shire plcsponsored adr | $6,303,000 | -4.0% | 36,216 | 0.0% | 0.27% | +13.4% | |
| ALGN | Buy | Align Technology, Inc. | $6,254,000 | +42.2% | 29,860 | +165.6% | 0.27% | +67.5% |
| DOC | Physicians Realty Trust | $6,268,000 | -4.9% | 391,016 | 0.0% | 0.27% | +12.1% | |
| GWPH | Buy | GW Pharmaceuticals plcads | $6,169,000 | -18.1% | 63,345 | +45.3% | 0.26% | -3.3% |
| IMMU | Buy | Immunomedics, Inc. | $6,158,000 | +203.6% | 431,527 | +343.2% | 0.26% | +256.8% |
| VTR | Ventas, Inc. | $5,771,000 | +7.7% | 98,496 | 0.0% | 0.25% | +27.3% | |
| PIRS | Pieris Pharmaceuticals, Inc. | $5,552,000 | -52.5% | 2,087,380 | 0.0% | 0.24% | -43.9% | |
| DGX | Buy | Quest Diagnostics Incorporated | $5,537,000 | +31.6% | 66,500 | +70.5% | 0.24% | +54.9% |
| ENDP | Sell | Endo International plcshares | $5,236,000 | -69.5% | 717,274 | -29.6% | 0.22% | -64.0% |
| ARRY | Array BioPharma Inc. | $5,189,000 | -6.3% | 364,166 | 0.0% | 0.22% | +10.4% | |
| STE | Buy | STERIS plcshares | $5,129,000 | +27.4% | 48,003 | +36.4% | 0.22% | +50.7% |
| MRUS | Sell | Merus N.V. | $5,147,000 | -37.0% | 367,671 | -11.2% | 0.22% | -25.7% |
| CRSP | CRISPR Therapeutics AGnamen akt | $5,095,000 | -35.6% | 178,348 | 0.0% | 0.22% | -24.0% | |
| XRAY | Buy | DENTSPLY SIRONA Inc. | $4,675,000 | +115.0% | 125,625 | +118.1% | 0.20% | +153.2% |
| IQV | Buy | IQVIA Holdings Inc. | $4,542,000 | +108.3% | 39,100 | +132.7% | 0.19% | +145.6% |
| UTHR | United Therapeutics Corporationclass b | $4,493,000 | -14.8% | 41,261 | 0.0% | 0.19% | +0.5% | |
| IONS | Ionis Pharmaceuticals, Inc. | $4,478,000 | +4.8% | 82,838 | 0.0% | 0.19% | +23.9% | |
| ACHC | Sell | ACADIA Pharmaceuticals Inc. | $4,452,000 | -53.6% | 173,155 | -36.4% | 0.19% | -45.1% |
| ALKS | Sell | Alkermes plcshares | $4,464,000 | -38.5% | 151,283 | -11.6% | 0.19% | -27.4% |
| SNH | Sell | Senior Housing Properties Trust | $4,421,000 | -61.1% | 377,220 | -41.7% | 0.19% | -54.1% |
| ANAB | Buy | AnaptysBio, Inc. | $4,200,000 | -8.3% | 65,845 | +43.4% | 0.18% | +8.4% |
| ZGNX | Buy | Zogenix, Inc. | $4,048,000 | +23.3% | 111,025 | +67.8% | 0.17% | +45.4% |
| ABMD | Buy | ABIOMED, Inc. | $4,014,000 | +137.9% | 12,350 | +229.3% | 0.17% | +182.0% |
| CLLS | Sell | Cellectis SAsponsored adr | $3,938,000 | -50.0% | 236,530 | -15.2% | 0.17% | -40.9% |
| GBT | Sell | Global Blood Therapeutics, Inc. | $3,856,000 | -23.3% | 93,924 | -29.0% | 0.16% | -9.3% |
| LH | Buy | Laboratory Corporation of America Holdingssponsored adr | $3,677,000 | +73.5% | 29,100 | +138.5% | 0.16% | +103.9% |
| WMGI | Sell | Wright Medical Group N.V.ordinary shares | $3,631,000 | -53.1% | 133,391 | -50.0% | 0.16% | -44.8% |
| LGND | Buy | Ligand Pharmaceuticals Incorporated | $3,589,000 | +46.3% | 26,450 | +195.9% | 0.15% | +73.0% |
| BHC | Bausch Health Companies Inc. | $3,546,000 | -28.1% | 192,000 | 0.0% | 0.15% | -15.1% | |
| LOXO | Loxo Oncology, Inc. | $3,445,000 | -18.0% | 24,595 | 0.0% | 0.15% | -3.3% | |
| RARE | Ultragenyx Pharmaceutical Inc. | $3,346,000 | -43.0% | 76,958 | 0.0% | 0.14% | -32.9% | |
| WELL | Welltower Inc. | $3,162,000 | +7.9% | 45,560 | 0.0% | 0.14% | +27.4% | |
| NKTR | Sell | Nektar Therapeutics | $3,102,000 | -76.1% | 94,384 | -55.6% | 0.13% | -71.7% |
| WCG | New | WellCare Health Plans, Inc. | $3,069,000 | – | 13,000 | +100.0% | 0.13% | – |
| ALBO | Albireo Pharma, Inc. | $3,066,000 | -25.6% | 125,000 | 0.0% | 0.13% | -12.1% | |
| PHG | Buy | Koninklijke Philips N.V.ny reg sh | $2,998,000 | +99.1% | 85,400 | +158.0% | 0.13% | +132.7% |
| VAR | Varian Medical Systems, Inc. | $2,972,000 | +1.2% | 26,227 | 0.0% | 0.13% | +19.8% | |
| CHRS | Buy | Coherus Biosciences, Inc. | $2,852,000 | +15.4% | 315,162 | +110.4% | 0.12% | +35.6% |
| INVA | Innoviva, Inc. | $2,820,000 | +14.5% | 161,603 | 0.0% | 0.12% | +36.0% | |
| SGMO | Buy | Sangamo Therapeutics, Inc. | $2,773,000 | -4.8% | 241,538 | +40.5% | 0.12% | +12.3% |
| NVRO | Nevro Corp. | $2,674,000 | -31.8% | 68,760 | 0.0% | 0.11% | -19.7% | |
| ASND | Sell | Ascendis Pharma A/Ssponsored adr | $2,656,000 | -43.0% | 42,399 | -35.5% | 0.11% | -32.5% |
| CRL | Charles River Laboratories International, Inc. | $2,566,000 | -15.9% | 22,670 | 0.0% | 0.11% | -0.9% | |
| INOV | Inovalon Holdings, Inc. | $2,498,000 | +41.1% | 176,163 | 0.0% | 0.11% | +67.2% | |
| VRNA | Verona Pharma plcsponsored adr | $2,475,000 | -28.1% | 275,000 | 0.0% | 0.11% | -15.2% | |
| THC | Sell | Tenet Healthcare Corporation | $2,419,000 | -48.3% | 141,136 | -14.2% | 0.10% | -38.8% |
| EPZM | Sell | Epizyme, Inc. | $2,377,000 | -53.8% | 385,872 | -20.5% | 0.10% | -45.5% |
| PTCT | Buy | PTC Therapeutics, Inc. | $2,356,000 | +3.6% | 68,652 | +41.9% | 0.10% | +23.2% |
| AGIO | Buy | Agios Pharmaceuticals, Inc. | $2,261,000 | -13.4% | 49,025 | +44.7% | 0.10% | +2.1% |
| PTLA | Portola Pharmaceuticals, Inc.sponsored adr | $2,254,000 | -26.7% | 115,448 | 0.0% | 0.10% | -13.5% | |
| MRNS | Buy | Marinus Pharmaceuticals, Inc. | $2,169,000 | -35.5% | 755,776 | +124.8% | 0.09% | -23.8% |
| FOMX | Sell | Foamix Pharmaceuticals Ltdshares | $2,158,000 | -48.2% | 601,205 | -17.3% | 0.09% | -39.1% |
| AVDL | Avadel Pharmaceuticals plcsponsored adr | $2,102,000 | -41.2% | 814,588 | 0.0% | 0.09% | -30.8% | |
| STRO | Sell | Sutro Biopharma, Inc. | $2,074,000 | -44.7% | 229,900 | -8.0% | 0.09% | -34.6% |
| NTLA | Buy | Intellia Therapeutics, Inc. | $2,051,000 | +4.4% | 150,290 | +118.9% | 0.09% | +23.9% |
| XNCR | New | Xencor, Inc. | $2,031,000 | – | 56,172 | +100.0% | 0.09% | – |
| ARNA | Sell | Arena Pharmaceuticals, Inc. | $2,036,000 | -52.8% | 52,262 | -44.3% | 0.09% | -44.2% |
| WAT | Waters Corporation | $2,037,000 | -3.1% | 10,800 | 0.0% | 0.09% | +14.5% | |
| MTD | Mettler-Toledo International Inc. | $1,980,000 | -7.1% | 3,500 | 0.0% | 0.08% | +10.4% | |
| HR | Healthcare Realty Trust Incorporated | $1,934,000 | -2.8% | 68,000 | 0.0% | 0.08% | +15.3% | |
| IOVA | Iovance Biotherapeutics, Inc. | $1,920,000 | -21.3% | 216,908 | 0.0% | 0.08% | -6.8% | |
| MYOK | MyoKardia, Inc. | $1,886,000 | -25.1% | 38,600 | 0.0% | 0.08% | -11.0% | |
| MASI | Sell | Masimo Corporation | $1,826,000 | -56.9% | 17,011 | -50.0% | 0.08% | -49.4% |
| EDIT | Editas Medicine, Inc. | $1,744,000 | -28.5% | 76,668 | 0.0% | 0.08% | -14.8% | |
| PBYI | Puma Biotechnology, Inc. | $1,696,000 | -55.6% | 83,340 | 0.0% | 0.07% | -47.5% | |
| INGN | New | Inogen, Inc. | $1,676,000 | – | 13,500 | +100.0% | 0.07% | – |
| TFX | Teleflex Incorporated | $1,649,000 | -2.8% | 6,379 | 0.0% | 0.07% | +14.5% | |
| ACIU | AC Immune SAshares | $1,624,000 | +18.1% | 171,813 | 0.0% | 0.07% | +40.0% | |
| PRGO | Perrigo Company plcshares | $1,445,000 | -45.3% | 37,300 | 0.0% | 0.06% | -35.4% | |
| NUVA | Buy | NuVasive, Inc. | $1,428,000 | +2.7% | 28,816 | +47.2% | 0.06% | +22.0% |
| AERI | Aerie Pharmaceuticals, Inc. | $1,400,000 | -41.3% | 38,770 | 0.0% | 0.06% | -31.0% | |
| RDY | New | Dr. Reddy's Laboratories Limited | $1,376,000 | – | 36,500 | +100.0% | 0.06% | – |
| ICPT | New | Intercept Pharmaceuticals, Inc. | $1,345,000 | – | 13,348 | +100.0% | 0.06% | – |
| CLVS | Clovis Oncology, Inc. | $1,354,000 | -38.8% | 75,400 | 0.0% | 0.06% | -27.5% | |
| PTGX | Sell | Protagonist Therapeutics, Inc. | $1,327,000 | -41.1% | 197,138 | -10.0% | 0.06% | -30.5% |
| ADAP | Sell | Adaptimmune Therapeutics plcsponsored adr | $1,314,000 | -72.4% | 228,496 | -35.0% | 0.06% | -67.6% |
| SNR | Sell | New Senior Investment Group Inc. | $1,297,000 | -58.4% | 314,747 | -40.5% | 0.06% | -50.4% |
| ARPO | Aerpio Pharmaceuticals, Inc. | $1,301,000 | -45.0% | 765,000 | 0.0% | 0.06% | -34.9% | |
| HCP | HCP, Inc. | $1,271,000 | +6.1% | 45,500 | 0.0% | 0.05% | +25.6% | |
| ITCI | Buy | Intra-Cellular Therapies, Inc. | $1,255,000 | +66.0% | 110,193 | +216.2% | 0.05% | +100.0% |
| AKBA | Sell | Akebia Therapeutics, Inc. | $1,183,000 | -49.7% | 213,942 | -19.8% | 0.05% | -40.0% |
| OVID | Sell | Ovid Therapeutics Inc.adr | $1,203,000 | -60.4% | 496,977 | -7.2% | 0.05% | -53.6% |
| HTA | Healthcare Trust of America, Inc. | $1,164,000 | -5.1% | 46,000 | 0.0% | 0.05% | +13.6% | |
| DERM | Sell | Dermira, Inc. | $1,162,000 | -54.5% | 161,579 | -31.0% | 0.05% | -46.2% |
| ARDX | Ardelyx, Inc. | $1,144,000 | -58.9% | 639,370 | 0.0% | 0.05% | -51.5% | |
| NITE | Sell | Nightstar Therapeutics plcadr | $1,140,000 | -62.8% | 98,929 | -34.0% | 0.05% | -55.9% |
| GHDX | Sell | Genomic Health, Inc. | $1,119,000 | -54.1% | 17,370 | -50.0% | 0.05% | -45.5% |
| BOLD | Buy | Audentes Therapeutics, Inc. | $1,121,000 | -26.9% | 52,574 | +35.7% | 0.05% | -14.3% |
| QURE | uniQure N.V.shares | $1,088,000 | -20.8% | 37,741 | 0.0% | 0.05% | -6.0% | |
| LIVN | Buy | LivaNova plcshares | $1,043,000 | +33.9% | 11,400 | +81.3% | 0.04% | +60.7% |
| NVAX | Novavax, Inc. | $1,051,000 | -2.1% | 571,000 | 0.0% | 0.04% | +15.4% | |
| SPPI | Spectrum Pharmaceuticals, Inc. | $1,003,000 | -47.9% | 114,670 | 0.0% | 0.04% | -38.6% | |
| TTPH | Tetraphase Pharmaceuticals, Inc. | $971,000 | -59.1% | 859,322 | 0.0% | 0.04% | -51.2% | |
| SNDX | Syndax Pharmaceuticals, Inc. | $890,000 | -44.9% | 200,000 | 0.0% | 0.04% | -35.6% | |
| MNKKQ | Mallinckrodt plcsponsored adr | $847,000 | -46.1% | 53,600 | 0.0% | 0.04% | -36.8% | |
| EVH | Sell | Evolent Health, Inc. | $841,000 | -64.9% | 42,150 | -50.0% | 0.04% | -58.6% |
| NVCR | New | Novocure Limitedordinary shares | $820,000 | – | 24,500 | +100.0% | 0.04% | – |
| IMGN | ImmunoGen, Inc. | $807,000 | -49.3% | 168,190 | 0.0% | 0.04% | -39.7% | |
| AFMD | Affimed N.V. | $790,000 | -28.5% | 254,000 | 0.0% | 0.03% | -15.0% | |
| HOLX | Hologic, Inc. | $803,000 | +0.2% | 19,546 | 0.0% | 0.03% | +17.2% | |
| Sell | Trillium Therapeutics Inc. | $763,000 | -71.9% | 446,099 | -4.8% | 0.03% | -66.7% | |
| MDGL | Madrigal Pharmaceuticals, Inc. | $752,000 | -47.3% | 6,670 | 0.0% | 0.03% | -38.5% | |
| Egalet Corporationnote 5.50% 4/1/20 | $700,000 | 0.0% | 7,000,000 | 0.0% | 0.03% | +20.0% | ||
| ARQL | ArQule, Inc. | $693,000 | -51.0% | 250,000 | 0.0% | 0.03% | -41.2% | |
| RYTM | Rhythm Pharmaceuticals, Inc. | $669,000 | -7.9% | 24,890 | 0.0% | 0.03% | +11.5% | |
| New | Takeda Pharmaceutical Co. Ltd.sponsored ads | $649,000 | – | 19,200 | +100.0% | 0.03% | – | |
| GMRE | Global Medical REIT Inc. | $653,000 | -5.5% | 73,400 | 0.0% | 0.03% | +12.0% | |
| LMAT | LeMaitre Vascular, Inc. | $642,000 | -39.0% | 27,150 | 0.0% | 0.03% | -28.9% | |
| MTEM | Molecular Templates, Inc. | $582,000 | -25.1% | 144,110 | 0.0% | 0.02% | -10.7% | |
| ATNX | Athenex, Inc. | $578,000 | -18.4% | 45,530 | 0.0% | 0.02% | -3.8% | |
| CYH | Community Health Systems, Inc. | $575,000 | -18.6% | 203,935 | 0.0% | 0.02% | -3.8% | |
| MRTX | Mirati Therapeutics, Inc. | $576,000 | -10.0% | 13,590 | 0.0% | 0.02% | +8.7% | |
| A | Sell | Agilent Technologies, Inc. | $553,000 | -86.2% | 8,200 | -85.6% | 0.02% | -83.4% |
| CNCE | Sell | Concert Pharmaceuticals, Inc. | $569,000 | -57.7% | 45,362 | -50.0% | 0.02% | -51.0% |
| ACHN | Sell | Achillion Pharmaceuticals, Inc. | $507,000 | -70.4% | 318,833 | -31.4% | 0.02% | -64.5% |
| LXRX | Lexicon Pharmaceuticals, Inc.sponsored adr | $465,000 | -37.8% | 70,000 | 0.0% | 0.02% | -25.9% | |
| VKTX | New | Viking Therapeutics, Inc. | $436,000 | – | 57,008 | +100.0% | 0.02% | – |
| ONCE | Sell | Spark Therapeutics, Inc. | $422,000 | -64.9% | 10,772 | -51.1% | 0.02% | -59.1% |
| EIDX | Eidos Therapeutics, Inc. | $384,000 | +38.1% | 27,900 | 0.0% | 0.02% | +60.0% | |
| CDTX | Cidara Therapeutics, Inc. | $373,000 | -46.6% | 158,784 | 0.0% | 0.02% | -36.0% | |
| ARWR | New | Arrowhead Pharmaceuticals, Inc. | $381,000 | – | 30,700 | +100.0% | 0.02% | – |
| CAH | Cardinal Health, Inc. | $281,000 | -17.4% | 6,300 | 0.0% | 0.01% | 0.0% | |
| ABIO | ARCA biopharma, Inc. | $271,000 | -40.3% | 811,227 | 0.0% | 0.01% | -25.0% | |
| ALQA | Sell | Alliqua BioMedical, Inc. | $278,000 | -25.9% | 148,500 | -10.0% | 0.01% | -14.3% |
| CLSD | Buy | Clearside Biomedical, Inc. | $177,000 | -65.2% | 165,330 | +100.0% | 0.01% | -55.6% |
| BLCM | Bellicum Pharmaceuticals, Inc. | $175,000 | -52.7% | 60,000 | 0.0% | 0.01% | -46.2% | |
| NCNA | NuCana plcsponsored adr | $142,000 | -42.0% | 9,823 | 0.0% | 0.01% | -33.3% | |
| QHCCQ | Quorum Health Corporation | $69,000 | -50.4% | 23,725 | 0.0% | 0.00% | -40.0% | |
| CLDX | Celldex Therapeutics, Inc. | $21,000 | -56.2% | 105,800 | 0.0% | 0.00% | -50.0% | |
| JNCE | Jounce Therapeutics, Inc. | $34,000 | -48.5% | 10,127 | 0.0% | 0.00% | -50.0% | |
| ASRT | Exit | Assertio Therapeutics, Inc. | $0 | – | -1,000 | -100.0% | 0.00% | – |
| MNLO | Exit | Menlo Therapeutics Inc. | $0 | – | -24,784 | -100.0% | -0.01% | – |
| XENT | Exit | Intersect ENT, Inc. | $0 | – | -8,356 | -100.0% | -0.01% | – |
| TBPH | Exit | Theravance Biopharma, Inc. | $0 | – | -8,083 | -100.0% | -0.01% | – |
| TLGT | Exit | Teligent, Inc. | $0 | – | -101,458 | -100.0% | -0.02% | – |
| RMR | Exit | The RMR Group Inc.class a | $0 | – | -5,323 | -100.0% | -0.02% | – |
| NLNK | Exit | NewLink Genetics Corporation | $0 | – | -205,026 | -100.0% | -0.02% | – |
| ECYT | Exit | Endocyte, Inc. | $0 | – | -41,980 | -100.0% | -0.03% | – |
| ARGX | Exit | argenx SEsponsored adr | $0 | – | -15,188 | -100.0% | -0.04% | – |
| CBAY | Exit | CymaBay Therapeutics, Inc. | $0 | – | -169,962 | -100.0% | -0.07% | – |
| RVNC | Exit | Revance Therapeutics, Inc. | $0 | – | -77,919 | -100.0% | -0.07% | – |
| ACAD | Exit | ACADIA Pharmaceuticals Inc. | $0 | – | -93,689 | -100.0% | -0.07% | – |
| RGEN | Exit | Repligen Corporation | $0 | – | -38,700 | -100.0% | -0.08% | – |
| HSIC | Exit | Henry Schein, Inc. | $0 | – | -31,400 | -100.0% | -0.10% | – |
| HZNP | Exit | Horizon Pharma plcshares | $0 | – | -162,900 | -100.0% | -0.12% | – |
| TSRO | Exit | TESARO, Inc. | $0 | – | -94,970 | -100.0% | -0.13% | – |
| ESRX | Exit | Express Scripts Holding Company | $0 | – | -53,250 | -100.0% | -0.18% | – |
| CI | Exit | Cigna Corporation | $0 | – | -40,461 | -100.0% | -0.31% | – |
| AET | Exit | Aetna Inc. | $0 | – | -83,637 | -100.0% | -0.62% | – |
Original filings
The following EDGAR filing(s) were analyzed to create this report:
- View 13F-HR filed 2019-02-13
Top long-term holdings
| Name | Quarters owned | Latest quarter owned | Max weighting |
|---|---|---|---|
| Gilead Sciences, Inc. | 41 | Q2 2023 | 12.4% |
| Amgen, Inc. | 41 | Q2 2023 | 5.8% |
| Biogen Inc. | 41 | Q2 2023 | 6.5% |
| Vertex Pharmaceuticals Incorporated | 41 | Q2 2023 | 5.3% |
| Regeneron Pharmaceuticals, Inc. | 41 | Q2 2023 | 9.1% |
| Illumina, Inc. | 41 | Q2 2023 | 3.4% |
| BioMarin Pharmaceutical Inc. | 41 | Q2 2023 | 2.9% |
| Teva Pharmaceutical Industries Ltd. | 41 | Q2 2023 | 3.2% |
| Neurocrine Biosciences, Inc. | 41 | Q2 2023 | 1.4% |
| McKesson Corporation | 41 | Q2 2023 | 2.2% |
View Tekla Capital Management LLC's complete holdings history.
Latest significant ownerships (13-D/G)
| Filed | Shares | Percentage | |
|---|---|---|---|
| Rallybio Corp | January 23, 2023 | 1,727,067 | 4.6% |
| Zyla Life SciencesSold out | January 29, 2021 | 0 | 0.0% |
| ARCA biopharma, Inc. | January 24, 2020 | 36,068 | 2.3% |
| Verona Pharma plc | February 12, 2019 | 5,296,845 | 4.9% |
| Alliqua BioMedical, Inc. | February 12, 2018 | 165,000 | 3.3% |
| PIERIS PHARMACEUTICALS, INC. | February 12, 2018 | 1,962,380 | 4.4% |
| Intellipharmaceutics International Inc. | February 13, 2015 | 2,184,000 | 9.0% |
| HERON THERAPEUTICS, INC. /DE/ | February 14, 2014 | 20,598,613 | 4.2% |
| MEDWAVE INC | February 14, 2012 | 1,277,372 | 9.8% |
| MZT Holdings, Inc. | February 14, 2012 | 2,553,420 | 4.0% |
View Tekla Capital Management LLC's complete significant-ownership history.
Latest filings
| Type | Filed |
|---|---|
| 13F-HR | 2023-08-10 |
| 13F-HR | 2023-05-10 |
| 13F-HR | 2023-02-10 |
| SC 13G/A | 2023-01-23 |
| 13F-HR | 2022-11-01 |
| 13F-HR | 2022-07-29 |
| 13F-HR | 2022-05-13 |
| 13F-HR | 2022-02-14 |
| SC 13G | 2022-01-21 |
| 13F-HR | 2021-11-12 |
View Tekla Capital Management LLC's complete filings history.
All filings
- Holdings (13F-HR)
- Significant ownership (13-D/G)
- Insider transactions (4, 5, 6)
- Events (8-K)
- Shareholder votes (proxy)
View complete filings history.