$14.7 Billion is the total value of Baker Brothers Advisors's 103 reported holdings in Q2 2019. The portfolio turnover from Q1 2019 to Q2 2019 was 15.6% .
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| SGEN | Sell | Seattle Genetics, Inc. | $3,464,464,000 | -7.3% | 50,057,277 | -1.9% | 23.54% | -1.6% |
| INCY | Sell | Incyte Corporation | $2,716,697,000 | -7.8% | 31,976,193 | -6.7% | 18.46% | -2.2% |
| BGNE | Sell | BeiGene, Ltd.sponsored adr | $1,459,794,000 | -7.5% | 11,777,285 | -1.5% | 9.92% | -1.8% |
| ALXN | Sell | Alexion Pharmaceuticals, Inc. | $1,081,642,000 | -6.5% | 8,258,068 | -3.5% | 7.35% | -0.7% |
| ACAD | Sell | ACADIA Pharmaceuticals Inc. | $1,050,277,000 | -1.5% | 39,292,086 | -1.1% | 7.14% | +4.6% |
| AMRN | Sell | Amarin Corporation plcsponsored adr | $805,544,000 | -10.2% | 41,544,288 | -3.9% | 5.48% | -4.6% |
| BMRN | BioMarin Pharmaceutical Inc. | $650,023,000 | -3.6% | 7,589,294 | 0.0% | 4.42% | +2.4% | |
| GHDX | Sell | Genomic Health, Inc. | $538,708,000 | -24.6% | 9,260,922 | -9.2% | 3.66% | -19.9% |
| ASND | Ascendis Pharma A/Ssponsored adr | $390,390,000 | -2.2% | 3,390,270 | 0.0% | 2.65% | +3.9% | |
| MRTX | Mirati Therapeutics, Inc. | $258,887,000 | +40.5% | 2,513,462 | 0.0% | 1.76% | +49.2% | |
| ARGX | argenx SEsponsored adr | $144,349,000 | +13.4% | 1,019,557 | 0.0% | 0.98% | +20.4% | |
| ARRY | Sell | Array BioPharma Inc. | $131,974,000 | +40.9% | 2,848,567 | -25.9% | 0.90% | +49.5% |
| MDGL | Madrigal Pharmaceuticals, Inc. | $122,552,000 | -16.3% | 1,169,278 | 0.0% | 0.83% | -11.2% | |
| NBIX | Buy | Neurocrine Biosciences, Inc. | $119,492,000 | +23.5% | 1,415,283 | +28.8% | 0.81% | +31.0% |
| HRTX | Buy | Heron Therapeutics, Inc. | $111,877,000 | -8.8% | 6,018,104 | +19.9% | 0.76% | -3.2% |
| KOD | Kodiak Sciences, Inc. | $106,998,000 | +79.2% | 9,145,115 | 0.0% | 0.73% | +90.3% | |
| NVTA | Invitae Corporation | $91,707,000 | +0.3% | 3,902,421 | 0.0% | 0.62% | +6.5% | |
| TCDA | Buy | Tricida, Inc. | $77,732,000 | +11.6% | 1,969,905 | +9.2% | 0.53% | +18.4% |
| ONCE | Spark Therapeutics, Inc. | $76,982,000 | -10.1% | 751,927 | 0.0% | 0.52% | -4.6% | |
| BCEL | New | Atreca, Inc. | $66,557,000 | – | 3,532,760 | +100.0% | 0.45% | – |
| GWPH | Sell | GW Pharmaceuticals plcads | $63,930,000 | -11.5% | 370,845 | -13.4% | 0.43% | -6.1% |
| INSM | Buy | Insmed Incorporated | $63,033,000 | +4.4% | 2,462,216 | +18.5% | 0.43% | +10.6% |
| CERS | Cerus Corporation | $60,415,000 | -9.8% | 10,749,937 | 0.0% | 0.41% | -4.2% | |
| RYTM | Rhythm Pharmaceuticals, Inc. | $59,580,000 | -19.7% | 2,708,200 | 0.0% | 0.40% | -14.7% | |
| PRNB | Principia Biopharma Inc. | $59,337,000 | -2.4% | 1,787,807 | 0.0% | 0.40% | +3.6% | |
| BOLD | Sell | Audentes Therapeutics, Inc. | $57,034,000 | -14.8% | 1,506,438 | -12.2% | 0.39% | -9.3% |
| ADPT | New | Adaptive Biotechnologies Corporation | $56,289,000 | – | 1,165,411 | +100.0% | 0.38% | – |
| BCRX | Sell | BioCryst Pharmaceuticals, Inc. | $54,510,000 | -55.7% | 14,382,673 | -4.9% | 0.37% | -53.0% |
| RARX | Buy | Ra Pharmaceuticals, Inc. | $54,177,000 | +193.8% | 1,801,695 | +118.9% | 0.37% | +211.9% |
| MYOK | MyoKardia, Inc. | $50,958,000 | -3.6% | 1,016,306 | 0.0% | 0.35% | +2.4% | |
| DBVT | DBV Technologies S.A.sponsored adr | $45,289,000 | +6.6% | 5,509,560 | 0.0% | 0.31% | +13.2% | |
| KRYS | Buy | Krystal Biotech, Inc. | $41,666,000 | +61.4% | 1,034,674 | +31.9% | 0.28% | +71.5% |
| CBAY | CymaBay Therapeutics, Inc. | $40,865,000 | -46.1% | 5,707,411 | 0.0% | 0.28% | -42.7% | |
| Sell | Neurocrine Biosciences, Inc.note 2.25% 5/15/2024 | $40,541,000 | -43.7% | 30,770,000 | -42.2% | 0.28% | -40.1% | |
| QURE | Sell | uniQure N.V. | $40,458,000 | +12.1% | 517,700 | -14.4% | 0.28% | +19.0% |
| KNSA | Sell | Kiniksa Pharmaceuticals, Ltd. | $37,906,000 | -30.0% | 2,799,577 | -6.7% | 0.26% | -25.6% |
| ZYME | Zymeworks Inc. | $37,586,000 | +36.0% | 1,708,472 | 0.0% | 0.26% | +44.1% | |
| AQXP | Aquinox Pharmaceuticals, Inc. | $25,805,000 | -12.4% | 10,934,154 | 0.0% | 0.18% | -7.4% | |
| AXSM | Sell | Axsome Therapeutics, Inc. | $19,886,000 | +16.5% | 772,286 | -35.6% | 0.14% | +23.9% |
| XNCR | Xencor, Inc. | $17,523,000 | +31.8% | 428,120 | 0.0% | 0.12% | +40.0% | |
| MRUS | Merus N.V. | $16,994,000 | -0.8% | 1,160,014 | 0.0% | 0.12% | +4.5% | |
| BioMarin Pharmaceutical Inc.note 0.599% 8/1/2024 | $15,566,000 | +1.2% | 15,000,000 | 0.0% | 0.11% | +8.2% | ||
| ACOR | Buy | Acorda Therapeutics, Inc. | $15,426,000 | +297.4% | 2,011,189 | +588.4% | 0.10% | +320.0% |
| LJPC | Buy | La Jolla Pharmaceutical Company | $14,423,000 | +343.9% | 1,559,231 | +208.6% | 0.10% | +366.7% |
| AIMT | Aimmune Therapeutics, Inc. | $14,031,000 | -6.8% | 673,908 | 0.0% | 0.10% | -1.0% | |
| IDRA | Sell | Idera Pharmaceuticals, Inc. | $12,298,000 | -0.4% | 4,605,822 | -4.8% | 0.08% | +6.3% |
| PTGX | Buy | Protagonist Therapeutics, Inc. | $12,050,000 | +137.3% | 995,082 | +146.4% | 0.08% | +156.2% |
| MRKR | Marker Therapeutics, Inc. | $11,880,000 | +20.0% | 1,500,000 | 0.0% | 0.08% | +28.6% | |
| AGLE | Aeglea BioTherapeutics, Inc. | $11,738,000 | -14.9% | 1,713,604 | 0.0% | 0.08% | -9.1% | |
| ASMB | Buy | Assembly Biosciences, Inc. | $10,836,000 | +270.3% | 803,246 | +440.6% | 0.07% | +289.5% |
| SGMO | Sangamo Therapeutics, Inc. | $10,768,000 | +12.9% | 999,823 | 0.0% | 0.07% | +19.7% | |
| CPRX | Sell | Catalyst Pharmaceuticals, Inc. | $9,828,000 | -33.5% | 2,559,461 | -11.7% | 0.07% | -29.5% |
| SYRS | Buy | Syros Pharmaceuticals, Inc. | $9,027,000 | +71.8% | 974,835 | +69.6% | 0.06% | +79.4% |
| ALKS | Buy | Alkermes plc | $9,016,000 | +268.8% | 400,000 | +497.0% | 0.06% | +281.2% |
| DERM | Dermira, Inc. | $8,670,000 | -29.4% | 906,943 | 0.0% | 0.06% | -25.3% | |
| ALBO | Albireo Pharma, Inc. | $8,060,000 | +0.1% | 250,000 | 0.0% | 0.06% | +5.8% | |
| APLS | Apellis Pharmaceuticals, Inc. | $7,950,000 | +29.9% | 313,725 | 0.0% | 0.05% | +38.5% | |
| MIST | New | Milestone Pharmaceuticals Inc. | $7,240,000 | – | 266,667 | +100.0% | 0.05% | – |
| ANAB | AnaptysBio, Inc. | $6,380,000 | -22.8% | 113,086 | 0.0% | 0.04% | -18.9% | |
| ABEO | Abeona Therapeutics Inc. | $6,158,000 | -35.0% | 1,288,235 | 0.0% | 0.04% | -31.1% | |
| HOOK | New | HOOKIPA Pharma Inc. | $6,009,000 | – | 892,857 | +100.0% | 0.04% | – |
| ORTX | Buy | Orchard Therapeutics plcads | $5,676,000 | +154.0% | 405,702 | +224.6% | 0.04% | +178.6% |
| HALO | Halozyme Therapeutics, Inc. | $5,153,000 | +6.7% | 299,969 | 0.0% | 0.04% | +12.9% | |
| BLUE | bluebird bio, Inc. | $5,088,000 | -19.1% | 40,000 | 0.0% | 0.04% | -12.5% | |
| BLCM | Bellicum Pharmaceuticals, Inc. | $4,552,000 | -49.6% | 2,677,818 | 0.0% | 0.03% | -46.6% | |
| MNLO | Menlo Therapeutics Inc. | $4,193,000 | -23.7% | 700,000 | 0.0% | 0.03% | -20.0% | |
| GTHX | G1 Therapeutics, Inc. | $3,901,000 | +84.7% | 127,236 | 0.0% | 0.03% | +92.9% | |
| NGM | New | NGM Biopharmaceuticals, Inc. | $3,660,000 | – | 250,000 | +100.0% | 0.02% | – |
| VKTX | Viking Therapeutics, Inc. | $3,528,000 | -16.5% | 425,000 | 0.0% | 0.02% | -11.1% | |
| CRNX | Buy | Crinetics Pharmaceuticals, Inc. | $3,325,000 | +11.3% | 132,985 | +1.3% | 0.02% | +21.1% |
| XLRN | Acceleron Pharma Inc. | $3,447,000 | -11.8% | 83,900 | 0.0% | 0.02% | -8.0% | |
| GLPG | Galapagos NVsponsored adr | $3,233,000 | +9.5% | 25,072 | 0.0% | 0.02% | +15.8% | |
| ACHN | Achillion Pharmaceuticals, Inc. | $2,936,000 | -9.4% | 1,095,359 | 0.0% | 0.02% | -4.8% | |
| XBIT | New | XBiotech Inc. | $2,884,000 | – | 380,442 | +100.0% | 0.02% | – |
| ARAV | Buy | Aravive, Inc. | $2,910,000 | -4.1% | 484,947 | +12.5% | 0.02% | +5.3% |
| HARP | Harpoon Therapeutics, Inc. | $2,786,000 | +37.3% | 214,285 | 0.0% | 0.02% | +46.2% | |
| FTSV | Forty Seven, Inc. | $2,650,000 | -34.4% | 250,000 | 0.0% | 0.02% | -30.8% | |
| AUTL | Autolus Therapeutics plcsponsored ads | $2,524,000 | -48.8% | 156,773 | 0.0% | 0.02% | -46.9% | |
| CYCN | New | Cyclerion Therapeutics, Inc. | $2,320,000 | – | 202,581 | +100.0% | 0.02% | – |
| YMAB | Y-mAbs Therapeutics, Inc. | $2,351,000 | -12.7% | 102,800 | 0.0% | 0.02% | -5.9% | |
| SBPH | Spring Bank Pharmaceuticals, Inc. | $2,263,000 | -64.8% | 613,144 | 0.0% | 0.02% | -63.4% | |
| NXTC | New | NextCure, Inc. | $2,247,000 | – | 150,000 | +100.0% | 0.02% | – |
| CTMX | CytomX Therapeutics, Inc. | $2,181,000 | +4.4% | 194,377 | 0.0% | 0.02% | +15.4% | |
| MTEM | Molecular Templates, Inc. | $2,123,000 | +43.7% | 254,230 | 0.0% | 0.01% | +55.6% | |
| IDYA | New | IDEAYA Biosciences, Inc. | $1,992,000 | – | 200,000 | +100.0% | 0.01% | – |
| NTLA | Intellia Therapeutics, Inc. | $2,104,000 | -4.1% | 128,538 | 0.0% | 0.01% | 0.0% | |
| CCXI | ChemoCentryx, Inc. | $1,925,000 | -33.1% | 207,029 | 0.0% | 0.01% | -27.8% | |
| GLMD | Galmed Pharmaceuticals Ltd. | $1,585,000 | -10.0% | 215,594 | 0.0% | 0.01% | 0.0% | |
| CNST | Constellation Pharmaceuticals, Inc. | $1,637,000 | -9.4% | 133,333 | 0.0% | 0.01% | -8.3% | |
| DOVA | New | Dova Pharmaceuticals, Inc. | $1,402,000 | – | 99,405 | +100.0% | 0.01% | – |
| ALRN | New | Aileron Therapeutics, Inc. | $1,469,000 | – | 2,040,000 | +100.0% | 0.01% | – |
| SRRA | Sierra Oncology, Inc. | $1,120,000 | -67.3% | 2,000,000 | 0.0% | 0.01% | -63.6% | |
| FOMX | Foamix Pharmaceuticals Ltd. | $1,186,000 | -36.5% | 498,189 | 0.0% | 0.01% | -33.3% | |
| ADMS | Adamas Pharmaceuticals, Inc. | $1,070,000 | -12.8% | 172,630 | 0.0% | 0.01% | -12.5% | |
| RCUS | Arcus Biosciences, Inc. | $966,000 | -36.4% | 121,534 | 0.0% | 0.01% | -30.0% | |
| INFI | Infinity Pharmaceuticals, Inc. | $1,045,000 | -4.2% | 580,400 | 0.0% | 0.01% | 0.0% | |
| FLGT | Fulgent Genetics, Inc. | $835,000 | +12.2% | 125,000 | 0.0% | 0.01% | +20.0% | |
| AFMD | Affimed N.V. | $574,000 | -31.7% | 200,000 | 0.0% | 0.00% | -20.0% | |
| AQST | Aquestive Therapeutics, Inc. | $418,000 | -39.2% | 99,600 | 0.0% | 0.00% | -25.0% | |
| SNSS | Sunesis Pharmaceuticals, Inc. | $405,000 | -40.1% | 556,665 | 0.0% | 0.00% | -25.0% | |
| RTTR | Ritter Pharmaceuticals, Inc. | $300,000 | +23.0% | 279,999 | 0.0% | 0.00% | 0.0% | |
| DVAX | Dynavax Technologies Corporation | $299,000 | -45.4% | 75,000 | 0.0% | 0.00% | -50.0% | |
| Trillium Therapeutics Inc. | $166,000 | -50.2% | 505,262 | 0.0% | 0.00% | -50.0% | ||
| CFRX | Exit | ContraFect Corporation | $0 | – | -2,914,536 | -100.0% | -0.01% | – |
| MGNX | Exit | MacroGenics, Inc. | $0 | – | -302,600 | -100.0% | -0.04% | – |
| IFRX | Exit | InflaRx N.V. | $0 | – | -178,987 | -100.0% | -0.04% | – |
| CMTA | Exit | Clementia Pharmaceuticals Inc. | $0 | – | -3,724,445 | -100.0% | -0.62% | – |
Original filings
The following EDGAR filing(s) were analyzed to create this report:
- View 13F-HR filed 2019-08-14
About Baker Brothers Advisors
Baker Brothers Advisors is a well-known investment management firm that specializes in the healthcare sector. The firm was founded in 2000 by brothers Julian and Felix Baker, who are both highly respected in the industry. Julian Baker is the CEO of the firm, while Felix Baker serves as a managing partner.
Baker Brothers Advisors has a reputation for investing in innovative healthcare companies that have the potential to make a significant impact on the industry. The firm has a long-term investment approach and is known for taking large positions in companies that it believes in. Some of the firm's most successful investments include companies such as Pharmacyclics, which was acquired by AbbVie for $21 billion, and Ariad Pharmaceuticals, which was acquired by Takeda for $5.2 billion.
The firm's investment strategy is led by its Chief Investment Officer, Dr. Robert Duggan, who has a background in both medicine and finance. Dr. Duggan is known for his ability to identify promising healthcare companies and for his willingness to take risks on early-stage companies.
Overall, Baker Brothers Advisors is a highly respected investment management firm that has a proven track record of success in the healthcare sector. While the firm's investment approach may not be suitable for all investors, those who are interested in the healthcare sector may want to consider Baker Brothers Advisors as a potential investment opportunity.
It's important to note that this information is for educational purposes only and has not been fact-checked. As with any investment, it's important to do your own research and consult with a financial advisor before making any investment decisions.
Top long-term holdings
| Name | Quarters owned | Latest quarter owned | Max weighting |
|---|---|---|---|
| Incyte Corporation | 42 | Q3 2023 | 37.6% |
| ACADIA Pharmaceuticals Inc. | 42 | Q3 2023 | 10.9% |
| Biomarin Pharmaceuticals Inc. | 42 | Q3 2023 | 5.9% |
| BioCryst Pharmaceuticals, Inc. | 42 | Q3 2023 | 1.7% |
| Cerus Corporation | 42 | Q3 2023 | 0.9% |
| Insmed Incorporated | 42 | Q3 2023 | 0.4% |
| Mirati Therapeutics, Inc. | 41 | Q3 2023 | 1.8% |
| Bluebird Bio Inc. | 41 | Q3 2023 | 0.3% |
| Heron Therapeutics, Inc. | 39 | Q3 2023 | 1.5% |
| ChemoCentryx, Inc. | 37 | Q3 2022 | 0.6% |
View Baker Brothers Advisors's complete holdings history.
Latest significant ownerships (13-D/G)
| Filed | Shares | Percentage | |
|---|---|---|---|
| Neoleukin Therapeutics, Inc. | August 17, 2023 | 9,469,838 | 20.0% |
| Mereo Biopharma Group plc | August 10, 2023 | 14,604,391 | 2.2% |
| Verastem, Inc. | August 10, 2023 | ? | ? |
| TScan Therapeutics, Inc. | June 02, 2023 | 2,793,938 | 6.5% |
| ACADIA PHARMACEUTICALS INC | May 24, 2023 | 43,084,280 | 26.5% |
| INCYTE CORP | March 15, 2023 | 36,280,967 | 16.3% |
| Seagen Inc. | March 13, 2023 | 46,985,656 | 25.1% |
| Talis Biomedical Corp | March 10, 2023 | 37,569,140 | 66.2% |
| Aeglea BioTherapeutics, Inc. | February 14, 2023 | 6,384,013 | 9.9% |
| Merus N.V. | February 14, 2023 | ? | ? |
View Baker Brothers Advisors's complete significant-ownership history.
Latest filings
| Type | Filed |
|---|---|
| 4 | 2024-04-23 |
| SC 13D/A | 2024-04-23 |
| 4 | 2024-04-22 |
| 3 | 2024-04-18 |
| SC 13D | 2024-04-18 |
| 3 | 2024-04-01 |
| 4 | 2024-04-01 |
| 4 | 2024-04-01 |
| 4 | 2024-04-01 |
| SC 13D | 2024-04-01 |
View Baker Brothers Advisors's complete filings history.
All filings
- Holdings (13F-HR)
- Significant ownership (13-D/G)
- Insider transactions (4, 5, 6)
- Events (8-K)
- Shareholder votes (proxy)
View complete filings history.