Artal Group S.A. Activity Q2 2012-Q3 2023

Q3 2023

			Value		Shares		↓ Weighting
MRTX	Sell	MIRATI THERAPEUTICS INC	$88,175	+18.7%	2,024,226	-1.5%	3.78%	+64.3%
BGNE	Sell	BEIGENE LTDsponsored adr	$72,656	-1.2%	403,934	-2.1%	3.12%	+36.7%
RVMD	Buy	REVOLUTION MEDICINES INC	$70,023	+9.0%	2,529,737	+5.3%	3.00%	+50.8%
APLS	Buy	APELLIS PHARMACEUTICALS INC	$63,320	-33.8%	1,664,572	+58.5%	2.72%	-8.4%
FOLD	Sell	AMICUS THERAPEUTICS INC	$49,401	-13.8%	4,062,567	-11.0%	2.12%	+19.3%
MORF	Sell	MORPHIC HLDG INC	$48,986	-60.1%	2,138,188	-0.1%	2.10%	-44.8%
CYTK	Buy	CYTOKINETICS INC	$44,745	-3.1%	1,518,831	+7.3%	1.92%	+34.0%
	New	NEUMORA THERAPEUTICS INC	$39,546	–	2,802,702	–	1.70%	–
MRTX	Buy	MIRATI THERAPEUTICS INCcall	$30,492	+237.6%	700,000	+180.0%	1.31%	+366.8%
	Buy	ACELYRIN INC	$25,113	-34.0%	2,469,279	+35.6%	1.08%	-8.7%
SLN	Buy	SILENCE THERAPEUTICS PLCads	$24,550	+162.6%	2,500,000	+47.1%	1.05%	+263.1%
IMGN	Buy	IMMUNOGEN INC	$23,997	+66.1%	1,512,113	+97.5%	1.03%	+129.7%
SE	Buy	SEA LTDsponsored ads	$17,448	-14.1%	397,000	+13.4%	0.75%	+18.7%
SDGR	Sell	SCHRODINGER INC	$14,135	-59.5%	500,000	-28.6%	0.61%	-44.0%
	Sell	VENTYX BIOSCIENCES INC	$14,074	+5.0%	405,239	-0.8%	0.60%	+45.3%
	New	RAYZEBIO INC	$12,333	–	555,556	–	0.53%	–
	Sell	ROIVANT SCIENCES LTD	$11,680	-28.7%	1,000,000	-38.5%	0.50%	-1.4%
TSHA	Buy	TAYSHA GENE THERAPIES INC	$11,575	+1115.9%	3,663,104	+154.2%	0.50%	+1553.3%
WVE	Sell	WAVE LIFE SCIENCES LTD	$11,500	+10.1%	2,000,000	-30.3%	0.49%	+52.2%
	Sell	VIGIL NEUROSCIENCE INC	$10,285	-42.7%	1,908,135	-0.2%	0.44%	-20.8%
TSM	Buy	TAIWAN SEMICONDUCTOR MFG LTDsponsored ads	$8,925	+108.1%	102,699	+141.6%	0.38%	+188.0%
	New	SAGIMET BIOSCIENCES INC	$8,138	–	924,771	–	0.35%	–
GOSS	Buy	GOSSAMER BIO INC	$5,330	+46.7%	6,399,819	+111.3%	0.23%	+102.7%
BEKE	Sell	KE HLDGS INCsponsored ads	$4,268	-17.9%	275,000	-21.4%	0.18%	+13.7%
PYPL	New	PAYPAL HLDGS INCcall	$1,871	–	32,000	–	0.08%	–
MSFT	Buy	MICROSOFT CORP	$1,737	+70.0%	5,500	+83.3%	0.07%	+131.2%
AMZN	Buy	AMAZON COM INC	$1,525	+16.9%	12,000	+20.0%	0.06%	+62.5%
DDOG	Buy	DATADOG INC	$1,048	+113.0%	11,500	+130.0%	0.04%	+200.0%
GOOGL	Buy	ALPHABET INCcap stk cl a	$720	+50.3%	5,500	+37.5%	0.03%	+106.7%
	New	CURIS INC	$692	–	105,000	–	0.03%	–
SQ	New	BLOCK INCcl a	$686	–	15,500	–	0.03%	–
NFLX	New	NETFLIX INC	$485	–	1,285	–	0.02%	–
	New	HARPOON THERAPEUTICS INC	$403	–	100,000	–	0.02%	–
PEGA	New	PEGASYSTEMS INC	$326	–	7,500	–	0.01%	–
CRWD	Sell	CROWDSTRIKE HLDGS INCcl a	$335	-34.8%	2,000	-42.9%	0.01%	-12.5%
INTA	New	INTAPP INC	$335	–	10,000	–	0.01%	–
PYPL	New	PAYPAL HLDGS INC	$292	–	5,000	–	0.01%	–
	Sell	MINK THERAPEUTICS INC	$2	-99.6%	1,916	-99.2%	0.00%	-100.0%
CFG	Exit	CITIZENS FINL GROUP INC	$0	–	-10,000	–	-0.01%	–
	Exit	STERLING CHECK CORP	$0	–	-25,000	–	-0.01%	–
KNTE	Exit	KINNATE BIOPHARMA INC	$0	–	-125,000	–	-0.01%	–
BMRN	Exit	BIOMARIN PHARMACEUTICAL INC	$0	–	-5,028	–	-0.01%	–
UTHR	Exit	UNITED THERAPEUTICS CORP DEL	$0	–	-2,971	–	-0.02%	–
HARP	Exit	HARPOON THERAPEUTICS INC	$0	–	-1,000,000	–	-0.02%	–
CRIS	Exit	CURIS INC	$0	–	-1,300,000	–	-0.03%	–
CRVS	Exit	CORVUS PHARMACEUTICALS INC	$0	–	-500,000	–	-0.04%	–
SANA	Exit	SANA BIOTECHNOLOGY INC	$0	–	-400,000	–	-0.07%	–
STOK	Exit	STOKE THERAPEUTICS INC	$0	–	-250,000	–	-0.08%	–
CGEM	Exit	CULLINAN ONCOLOGY INC	$0	–	-250,000	–	-0.08%	–
	Exit	LUCID GROUP INC	$0	–	-490,000	–	-0.10%	–
ALXO	Exit	ALX ONCOLOGY HLDGS INC	$0	–	-500,000	–	-0.12%	–
	Exit	PORTAGE FINTECH ACQUISITN CO	$0	–	-380,000	–	-0.12%	–
MORF	Exit	MORPHIC HLDG INCcall	$0	–	-100,000	–	-0.18%	–
ARAV	Exit	ARAVIVE INC	$0	–	-4,572,515	–	-0.18%	–
MRSN	Exit	MERSANA THERAPEUTICS INC	$0	–	-3,029,555	–	-0.31%	–
DHR	Exit	DANAHER CORPORATION	$0	–	-47,500	–	-0.35%	–
AMAM	Exit	AMBRX BIOPHARMA INCsponsored ads	$0	–	-702,291	–	-0.36%	–
PTGX	Exit	PROTAGONIST THERAPEUTICS INC	$0	–	-500,000	–	-0.43%	–
RLAY	Exit	RELAY THERAPEUTICS INC	$0	–	-1,213,725	–	-0.47%	–
	Exit	MOONLAKE IMMUNOTHERAPEUTICSclass a ord	$0	–	-400,000	–	-0.63%	–
SAGE	Exit	SAGE THERAPEUTICS INC	$0	–	-500,000	–	-0.73%	–
KRYS	Exit	KRYSTAL BIOTECH INC	$0	–	-349,669	–	-1.27%	–
XBI	Exit	SPDR SER TRcall	$0	–	-1,000,000	–	-2.58%	–

Q2 2023

			Value		Shares		↓ Weighting
	New	CAVA GROUP INC	$1,310,727	–	32,007,990	–	40.62%	–
LXRX	New	LEXICON PHARMACEUTICALS INC	$269,197	–	117,553,284	–	8.34%	–
MORF	New	MORPHIC HLDG INC	$122,686	–	2,139,995	–	3.80%	–
APLS	New	APELLIS PHARMACEUTICALS INC	$95,661	–	1,050,067	–	2.96%	–
XBI	New	SPDR SER TRcall	$83,200	–	1,000,000	–	2.58%	–
MRTX	New	MIRATI THERAPEUTICS INC	$74,254	–	2,055,181	–	2.30%	–
BGNE	New	BEIGENE LTDsponsored adr	$73,548	–	412,496	–	2.28%	–
SRRK	New	SCHOLAR ROCK HLDG CORP	$68,309	–	9,059,507	–	2.12%	–
RVMD	New	REVOLUTION MEDICINES INC	$64,243	–	2,401,617	–	1.99%	–
FOLD	New	AMICUS THERAPEUTICS INC	$57,306	–	4,562,567	–	1.78%	–
CERE	New	CEREVEL THERAPEUTICS HLDNG I	$52,099	–	1,638,858	–	1.62%	–
SWTX	New	SPRINGWORKS THERAPEUTICS INC	$47,632	–	1,816,620	–	1.48%	–
CYTK	New	CYTOKINETICS INC	$46,191	–	1,416,031	–	1.43%	–
KYMR	New	KYMERA THERAPEUTICS INC	$41,505	–	1,805,346	–	1.29%	–
KRYS	New	KRYSTAL BIOTECH INC	$41,051	–	349,669	–	1.27%	–
	New	ACELYRIN INC	$38,063	–	1,821,214	–	1.18%	–
SDGR	New	SCHRODINGER INC	$34,944	–	700,000	–	1.08%	–
AGEN	New	AGENUS INC	$25,010	–	15,631,235	–	0.78%	–
DNLI	New	DENALI THERAPEUTICS INC	$23,694	–	802,899	–	0.73%	–
SAGE	New	SAGE THERAPEUTICS INC	$23,510	–	500,000	–	0.73%	–
IGMS	New	IGM BIOSCIENCES INC	$23,280	–	2,522,244	–	0.72%	–
ALVR	New	ALLOVIR INC	$22,430	–	6,597,167	–	0.70%	–
KURA	New	KURA ONCOLOGY INC	$21,351	–	2,018,056	–	0.66%	–
	New	MOONLAKE IMMUNOTHERAPEUTICSclass a ord	$20,400	–	400,000	–	0.63%	–
SE	New	SEA LTDsponsored ads	$20,314	–	350,000	–	0.63%	–
SEER	New	SEER INC	$20,283	–	4,750,000	–	0.63%	–
	New	VIGIL NEUROSCIENCE INC	$17,965	–	1,911,191	–	0.56%	–
GERN	New	GERON CORP	$17,867	–	5,565,889	–	0.55%	–
	New	ROIVANT SCIENCES LTD	$16,380	–	1,625,000	–	0.51%	–
GBIO	New	GENERATION BIO CO	$15,478	–	2,814,191	–	0.48%	–
RLAY	New	RELAY THERAPEUTICS INC	$15,244	–	1,213,725	–	0.47%	–
GLYC	New	GLYCOMIMETICS INC	$14,945	–	8,589,064	–	0.46%	–
IMGN	New	IMMUNOGEN INC	$14,445	–	765,497	–	0.45%	–
	New	OMEGA THERAPEUTICS INC	$14,185	–	2,533,045	–	0.44%	–
PTGX	New	PROTAGONIST THERAPEUTICS INC	$13,810	–	500,000	–	0.43%	–
	New	VENTYX BIOSCIENCES INC	$13,399	–	408,519	–	0.42%	–
	New	ERASCA INC	$13,030	–	4,721,194	–	0.40%	–
ALPN	New	ALPINE IMMUNE SCIENCES INC	$12,264	–	1,193,030	–	0.38%	–
IKNA	New	IKENA ONCOLOGY INC	$12,133	–	1,849,513	–	0.38%	–
FHTX	New	FOGHORN THERAPEUTICS INC	$12,114	–	1,720,720	–	0.38%	–
VRDN	New	VIRIDIAN THERAPEUTICS INC	$12,013	–	504,978	–	0.37%	–
REPL	New	REPLIMUNE GROUP INC	$11,610	–	500,000	–	0.36%	–
AMAM	New	AMBRX BIOPHARMA INCsponsored ads	$11,560	–	702,291	–	0.36%	–
DHR	New	DANAHER CORPORATION	$11,400	–	47,500	–	0.35%	–
NTLA	New	INTELLIA THERAPEUTICS INC	$11,258	–	276,077	–	0.35%	–
WVE	New	WAVE LIFE SCIENCES LTD	$10,449	–	2,870,523	–	0.32%	–
BDTX	New	BLACK DIAMOND THERAPEUTICS I	$10,335	–	2,046,517	–	0.32%	–
SELB	New	SELECTA BIOSCIENCES INC	$10,233	–	9,136,635	–	0.32%	–
MRSN	New	MERSANA THERAPEUTICS INC	$9,967	–	3,029,555	–	0.31%	–
NTRA	New	NATERA INC	$9,732	–	200,000	–	0.30%	–
AUPH	New	AURINIA PHARMACEUTICALS INC	$9,680	–	1,000,000	–	0.30%	–
SLN	New	SILENCE THERAPEUTICS PLCads	$9,350	–	1,700,000	–	0.29%	–
DYN	New	DYNE THERAPEUTICS INC	$9,170	–	815,085	–	0.28%	–
MRTX	New	MIRATI THERAPEUTICS INCcall	$9,033	–	250,000	–	0.28%	–
VOR	New	VOR BIOPHARMA INC	$8,306	–	2,688,015	–	0.26%	–
OVID	New	OVID THERAPEUTICS INC	$8,200	–	2,500,000	–	0.25%	–
FUSN	New	FUSION PHARMACEUTICALS INC	$8,056	–	1,725,000	–	0.25%	–
RPTX	New	REPARE THERAPEUTICS INC	$7,406	–	700,000	–	0.23%	–
FOLD	New	AMICUS THERAPEUTICS INCcall	$6,280	–	500,000	–	0.20%	–
DAWN	New	DAY ONE BIOPHARMACEUTICALS I	$5,970	–	500,000	–	0.18%	–
ARAV	New	ARAVIVE INC	$5,761	–	4,572,515	–	0.18%	–
MORF	New	MORPHIC HLDG INCcall	$5,733	–	100,000	–	0.18%	–
VERV	New	VERVE THERAPEUTICS INC	$5,625	–	300,000	–	0.17%	–
ITOS	New	ITEOS THERAPEUTICS INC	$5,296	–	400,000	–	0.16%	–
BEKE	New	KE HLDGS INCsponsored ads	$5,198	–	350,000	–	0.16%	–
NBTX	New	NANOBIOTIXsponsored ads	$5,070	–	1,000,000	–	0.16%	–
HOOK	New	HOOKIPA PHARMA INC	$4,986	–	5,666,410	–	0.16%	–
	New	SOLID BIOSCIENCES INC	$4,764	–	909,219	–	0.15%	–
	New	SYROS PHARMACEUTICALS INC	$4,649	–	1,475,744	–	0.14%	–
TSM	New	TAIWAN SEMICONDUCTOR MFG LTDsponsored ads	$4,289	–	42,500	–	0.13%	–
	New	PORTAGE FINTECH ACQUISITN CO	$3,941	–	380,000	–	0.12%	–
ALXO	New	ALX ONCOLOGY HLDGS INC	$3,755	–	500,000	–	0.12%	–
GOSS	New	GOSSAMER BIO INC	$3,634	–	3,028,171	–	0.11%	–
	New	LUCID GROUP INC	$3,376	–	490,000	–	0.10%	–
RNA	New	AVIDITY BIOSCIENCES INC	$3,327	–	300,000	–	0.10%	–
BZ	New	KANZHUN LIMITEDsponsored ads	$3,311	–	220,000	–	0.10%	–
TALS	New	TALARIS THERAPEUTICS INC	$2,779	–	914,262	–	0.09%	–
CGEM	New	CULLINAN ONCOLOGY INC	$2,690	–	250,000	–	0.08%	–
KRON	New	KRONOS BIO INC	$2,654	–	1,542,954	–	0.08%	–
STOK	New	STOKE THERAPEUTICS INC	$2,658	–	250,000	–	0.08%	–
IMAB	New	I MABsponsored ads	$2,542	–	850,000	–	0.08%	–
SANA	New	SANA BIOTECHNOLOGY INC	$2,384	–	400,000	–	0.07%	–
ACHL	New	ACHILLES THERAPEUTICS PLCsponsored ads	$2,132	–	2,255,375	–	0.07%	–
V	New	VISA INC	$1,781	–	7,500	–	0.06%	–
ADAG	New	ADAGENE INCads	$1,480	–	1,000,000	–	0.05%	–
AMZN	New	AMAZON COM INC	$1,304	–	10,000	–	0.04%	–
	New	XILIO THERAPEUTICS INC	$1,179	–	450,000	–	0.04%	–
ME	New	23ANDME HOLDING CO	$1,157	–	661,009	–	0.04%	–
IRWD	New	IRONWOOD PHARMACEUTICALS INC	$1,176	–	110,532	–	0.04%	–
CRVS	New	CORVUS PHARMACEUTICALS INC	$1,145	–	500,000	–	0.04%	–
CRIS	New	CURIS INC	$1,079	–	1,300,000	–	0.03%	–
ADAP	New	ADAPTIMMUNE THERAPEUTICS PLCsponds adr	$1,049	–	1,133,775	–	0.03%	–
MSFT	New	MICROSOFT CORP	$1,022	–	3,000	–	0.03%	–
TSHA	New	TAYSHA GENE THERAPIES INC	$952	–	1,440,882	–	0.03%	–
HARP	New	HARPOON THERAPEUTICS INC	$710	–	1,000,000	–	0.02%	–
AMD	New	ADVANCED MICRO DEVICES INC	$683	–	6,000	–	0.02%	–
UTHR	New	UNITED THERAPEUTICS CORP DEL	$656	–	2,971	–	0.02%	–
	New	CYCLERION THERAPEUTICS INC	$570	–	138,403	–	0.02%	–
CRWD	New	CROWDSTRIKE HLDGS INCcl a	$514	–	3,500	–	0.02%	–
	New	MINK THERAPEUTICS INC	$479	–	228,216	–	0.02%	–
DDOG	New	DATADOG INC	$492	–	5,000	–	0.02%	–
GOOGL	New	ALPHABET INCcap stk cl a	$479	–	4,000	–	0.02%	–
BMRN	New	BIOMARIN PHARMACEUTICAL INC	$436	–	5,028	–	0.01%	–
	New	CARIBOU BIOSCIENCES INC	$448	–	105,347	–	0.01%	–
SQZ	New	SQZ BIOTECHNOLOGIES CO	$434	–	1,606,309	–	0.01%	–
LVTX	New	LAVA THERAPEUTICS NV	$406	–	200,000	–	0.01%	–
KNTE	New	KINNATE BIOPHARMA INC	$379	–	125,000	–	0.01%	–
	New	HIPPO HLDGS INC	$397	–	24,000	–	0.01%	–
BEAM	New	BEAM THERAPEUTICS INC	$350	–	10,975	–	0.01%	–
	New	STERLING CHECK CORP	$307	–	25,000	–	0.01%	–
PCOR	New	PROCORE TECHNOLOGIES INC	$293	–	4,500	–	0.01%	–
CFG	New	CITIZENS FINL GROUP INC	$261	–	10,000	–	0.01%	–
ALNY	New	ALNYLAM PHARMACEUTICALS INC	$178	–	936	–	0.01%	–
ARWR	New	ARROWHEAD PHARMACEUTICALS IN	$194	–	5,440	–	0.01%	–
	New	KINETA INC	$80	–	31,055	–	0.00%	–
PLRX	New	PLIANT THERAPEUTICS INC	$27	–	1,490	–	0.00%	–
	New	SENTI BIOSCIENCES INC	$35	–	55,555	–	0.00%	–
CYCN	New	CYCLERION THERAPEUTICS INC	$2	–	552	–	0.00%	–

Q4 2022

			Value		Shares		↓ Weighting
CDTX	Exit	CIDARA THERAPEUTICS INC	$0	–	-224,675	–	-0.01%	–
SGTX	Exit	SIGILON THERAPEUTICS INC	$0	–	-276,000	–	-0.01%	–
CDAK	Exit	CODIAK BIOSCIENCES INC	$0	–	-200,000	–	-0.01%	–
CFRX	Exit	CONTRAFECT CORP	$0	–	-1,500,000	–	-0.01%	–
	Exit	ASTRIA THERAPEUTICS INC	$0	–	-33,333	–	-0.01%	–
YMTX	Exit	YUMANITY THERAPEUTICS INC	$0	–	-217,391	–	-0.02%	–
ADBE	Exit	ADOBE SYSTEMS INCORPORATED	$0	–	-1,300	–	-0.02%	–
APLT	Exit	APPLIED THERAPEUTICS INC	$0	–	-400,000	–	-0.02%	–
CRVS	Exit	CORVUS PHARMACEUTICALS INC	$0	–	-500,000	–	-0.02%	–
MEIP	Exit	MEI PHARMA INC	$0	–	-1,000,000	–	-0.02%	–
	Exit	HIPPO HLDGS INC	$0	–	-24,000	–	-0.02%	–
MTCR	Exit	METACRINE INC	$0	–	-924,898	–	-0.02%	–
	Exit	MINK THERAPEUTICS INC	$0	–	-289,588	–	-0.03%	–
NEXI	Exit	NEXIMMUNE INC	$0	–	-1,200,000	–	-0.03%	–
OLMA	Exit	OLEMA PHARMACEUTICALS INC	$0	–	-260,500	–	-0.03%	–
RUBY	Exit	RUBIUS THERAPEUTICS INC	$0	–	-2,042,666	–	-0.04%	–
AVTR	Exit	AVANTOR INC	$0	–	-45,000	–	-0.04%	–
ORTX	Exit	ORCHARD THERAPEUTICS PLCspon ads	$0	–	-1,803,858	–	-0.04%	–
LVTX	Exit	LAVA THERAPEUTICS NV	$0	–	-200,000	–	-0.04%	–
CRIS	Exit	CURIS INC	$0	–	-1,300,000	–	-0.04%	–
HARP	Exit	HARPOON THERAPEUTICS INC	$0	–	-1,000,000	–	-0.04%	–
SPRO	Exit	SPERO THERAPEUTICS INC	$0	–	-500,000	–	-0.04%	–
	Exit	MARINUS PHARMACEUTICALS INC	$0	–	-157,000	–	-0.04%	–
ARAV	Exit	ARAVIVE INC	$0	–	-1,311,291	–	-0.05%	–
	Exit	CARIBOU BIOSCIENCES INC	$0	–	-105,347	–	-0.05%	–
IRWD	Exit	IRONWOOD PHARMACEUTICALS INC	$0	–	-110,532	–	-0.05%	–
IGMS	Exit	IGM BIOSCIENCES INCcall	$0	–	-50,000	–	-0.05%	–
CRDF	Exit	CARDIFF ONCOLOGY INC	$0	–	-750,000	–	-0.05%	–
AXLA	Exit	AXCELLA HEALTH INC	$0	–	-712,500	–	-0.05%	–
ORIC	Exit	ORIC PHARMACEUTICALS INC	$0	–	-400,000	–	-0.06%	–
MREO	Exit	MEREO BIOPHARMA GROUP PLCspon ads	$0	–	-1,500,000	–	-0.06%	–
ADAG	Exit	ADAGENE INCads	$0	–	-1,000,000	–	-0.06%	–
	Exit	XILIO THERAPEUTICS INC	$0	–	-450,000	–	-0.06%	–
TCRR	Exit	TCR2 THERAPEUTICS INC	$0	–	-750,000	–	-0.06%	–
SLDB	Exit	SOLID BIOSCIENCES INC	$0	–	-3,000,000	–	-0.06%	–
KNTE	Exit	KINNATE BIOPHARMA INC	$0	–	-125,000	–	-0.06%	–
IMMP	Exit	IMMUTEP LTDsponsored ads	$0	–	-1,000,000	–	-0.07%	–
YI	Exit	111 INCads	$0	–	-686,431	–	-0.08%	–
ME	Exit	23ANDME HOLDING CO	$0	–	-661,009	–	-0.08%	–
GRTS	Exit	GRITSTONE BIO INC	$0	–	-750,000	–	-0.08%	–
TSHA	Exit	TAYSHA GENE THERAPIES INC	$0	–	-1,040,882	–	-0.09%	–
TIL	Exit	INSTIL BIO INC	$0	–	-450,000	–	-0.09%	–
VOR	Exit	VOR BIOPHARMA INC	$0	–	-550,000	–	-0.09%	–
IMUX	Exit	IMMUNIC INC	$0	–	-700,000	–	-0.09%	–
GRPH	Exit	GRAPHITE BIO INC	$0	–	-700,000	–	-0.10%	–
FUSN	Exit	FUSION PHARMACEUTICALS INC	$0	–	-750,000	–	-0.10%	–
APTX	Exit	APTINYX INC	$0	–	-6,116,493	–	-0.10%	–
	Exit	SENTI BIOSCIENCES INC	$0	–	-1,055,555	–	-0.10%	–
	Exit	MINERVA NEUROSCIENCES INC	$0	–	-250,000	–	-0.10%	–
AMAM	Exit	AMBRX BIOPHARMA INCsponsored ads	$0	–	-2,152,291	–	-0.10%	–
CYCN	Exit	CYCLERION THERAPEUTICS INC	$0	–	-2,779,122	–	-0.10%	–
SANA	Exit	SANA BIOTECHNOLOGY INC	$0	–	-400,000	–	-0.10%	–
HOOK	Exit	HOOKIPA PHARMA INC	$0	–	-1,849,616	–	-0.11%	–
BBIO	Exit	BRIDGEBIO PHARMA INC	$0	–	-250,000	–	-0.11%	–
PRAX	Exit	PRAXIS PRECISION MEDICINES I	$0	–	-1,200,000	–	-0.12%	–
ZYME	Exit	ZYMEWORKS INC	$0	–	-450,000	–	-0.12%	–
BDTX	Exit	BLACK DIAMOND THERAPEUTICS I	$0	–	-1,646,517	–	-0.12%	–
ACIU	Exit	AC IMMUNE SA	$0	–	-1,000,000	–	-0.14%	–
STOK	Exit	STOKE THERAPEUTICS INC	$0	–	-250,000	–	-0.14%	–
CGEM	Exit	CULLINAN ONCOLOGY INC	$0	–	-250,000	–	-0.14%	–
IMAB	Exit	I MABsponsored ads	$0	–	-850,000	–	-0.14%	–
LPTX	Exit	LEAP THERAPEUTICS INC	$0	–	-4,000,000	–	-0.15%	–
NBTX	Exit	NANOBIOTIXsponsored ads	$0	–	-1,000,000	–	-0.15%	–
SQZ	Exit	SQZ BIOTECHNOLOGIES CO	$0	–	-1,606,309	–	-0.16%	–
	Exit	PORTAGE FINTECH ACQUISITN CO	$0	–	-380,000	–	-0.16%	–
	Exit	MIRION TECHNOLOGIES INC	$0	–	-500,000	–	-0.16%	–
	Exit	THIRD HARMONIC BIO INC	$0	–	-200,000	–	-0.16%	–
CNCE	Exit	CONCERT PHARMACEUTICALS INC	$0	–	-573,062	–	-0.16%	–
OTLY	Exit	OATLY GROUP ABsponsored ads	$0	–	-1,500,000	–	-0.17%	–
RNA	Exit	AVIDITY BIOSCIENCES INC	$0	–	-250,000	–	-0.17%	–
NTRA	Exit	NATERA INC	$0	–	-100,000	–	-0.19%	–
	Exit	EXSCIENTIA PLCads	$0	–	-550,000	–	-0.19%	–
OVID	Exit	OVID THERAPEUTICS INC	$0	–	-2,500,000	–	-0.20%	–
RXRX	Exit	RECURSION PHARMACEUTICALS INcl a	$0	–	-450,000	–	-0.20%	–
ALXO	Exit	ALX ONCOLOGY HLDGS INC	$0	–	-500,000	–	-0.20%	–
ACHL	Exit	ACHILLES THERAPEUTICS PLCsponsored ads	$0	–	-2,255,375	–	-0.22%	–
LYEL	Exit	LYELL IMMUNOPHARMA INC	$0	–	-700,000	–	-0.22%	–
KRON	Exit	KRONOS BIO INC	$0	–	-1,542,954	–	-0.22%	–
TALS	Exit	TALARIS THERAPEUTICS INC	$0	–	-2,064,262	–	-0.23%	–
IKNA	Exit	IKENA ONCOLOGY INC	$0	–	-1,549,513	–	-0.24%	–
YMAB	Exit	Y-MABS THERAPEUTICS INC	$0	–	-400,000	–	-0.25%	–
DYN	Exit	DYNE THERAPEUTICS INC	$0	–	-525,000	–	-0.28%	–
BGNE	Exit	BEIGENE LTDcall	$0	–	-50,000	–	-0.29%	–
OMEG	Exit	OMEGA ALPHA SPACcl a	$0	–	-750,000	–	-0.32%	–
AUPH	Exit	AURINIA PHARMACEUTICALS INC	$0	–	-1,000,000	–	-0.32%	–
ITOS	Exit	ITEOS THERAPEUTICS INC	$0	–	-400,000	–	-0.32%	–
SELB	Exit	SELECTA BIOSCIENCES INC	$0	–	-4,883,200	–	-0.34%	–
AGEN	Exit	AGENUS INC	$0	–	-4,000,000	–	-0.35%	–
RPTX	Exit	REPARE THERAPEUTICS INC	$0	–	-700,000	–	-0.36%	–
ALPN	Exit	ALPINE IMMUNE SCIENCES INC	$0	–	-1,193,030	–	-0.37%	–
ISEE	Exit	IVERIC BIO INCcall	$0	–	-500,000	–	-0.38%	–
	Exit	SYROS PHARMACEUTICALS INC	$0	–	-1,463,829	–	-0.40%	–
SE	Exit	SEA LTDsponsored ads	$0	–	-172,500	–	-0.41%	–
EVTCY	Exit	EVOTEC AGsponsored ads	$0	–	-1,149,425	–	-0.43%	–
WVE	Exit	WAVE LIFE SCIENCES LTD	$0	–	-3,000,000	–	-0.46%	–
	Exit	OMEGA THERAPEUTICS INC	$0	–	-2,273,530	–	-0.53%	–
ISEE	Exit	IVERIC BIO INC	$0	–	-750,000	–	-0.57%	–
SGEN	Exit	SEAGEN INCcall	$0	–	-100,000	–	-0.58%	–
VERV	Exit	VERVE THERAPEUTICS INC	$0	–	-400,000	–	-0.59%	–
FHTX	Exit	FOGHORN THERAPEUTICS INC	$0	–	-1,720,720	–	-0.63%	–
MRSN	Exit	MERSANA THERAPEUTICS INC	$0	–	-2,200,000	–	-0.64%	–
GBIO	Exit	GENERATION BIO CO	$0	–	-2,814,191	–	-0.64%	–
KURA	Exit	KURA ONCOLOGY INC	$0	–	-1,100,000	–	-0.64%	–
NTLA	Exit	INTELLIA THERAPEUTICS INC	$0	–	-275,000	–	-0.66%	–
REPL	Exit	REPLIMUNE GROUP INC	$0	–	-900,000	–	-0.66%	–
SDGR	Exit	SCHRODINGER INC	$0	–	-700,000	–	-0.75%	–
DNLI	Exit	DENALI THERAPEUTICS INC	$0	–	-600,000	–	-0.79%	–
	Exit	EQRX INC	$0	–	-4,000,000	–	-0.84%	–
	Exit	VIGIL NEUROSCIENCE INC	$0	–	-2,285,574	–	-0.89%	–
	Exit	ERASCA INC	$0	–	-3,172,221	–	-1.06%	–
KRTX	Exit	KARUNA THERAPEUTICS INC	$0	–	-125,000	–	-1.20%	–
SAGE	Exit	SAGE THERAPEUTICS INC	$0	–	-750,000	–	-1.25%	–
RLAY	Exit	RELAY THERAPEUTICS INC	$0	–	-1,454,716	–	-1.39%	–
KYMR	Exit	KYMERA THERAPEUTICS INC	$0	–	-1,500,000	–	-1.39%	–
KRYS	Exit	KRYSTAL BIOTECH INC	$0	–	-500,000	–	-1.49%	–
SEER	Exit	SEER INC	$0	–	-4,750,000	–	-1.57%	–
GOSS	Exit	GOSSAMER BIO INC	$0	–	-3,246,624	–	-1.66%	–
FOLD	Exit	AMICUS THERAPEUTICS INC	$0	–	-4,000,000	–	-1.78%	–
ALVR	Exit	ALLOVIR INC	$0	–	-5,577,167	–	-1.88%	–
SGEN	Exit	SEAGEN INC	$0	–	-350,000	–	-2.04%	–
CYTK	Exit	CYTOKINETICS INC	$0	–	-1,000,000	–	-2.07%	–
ARGX	Exit	ARGENX SEsponsored adr	$0	–	-150,000	–	-2.26%	–
IGMS	Exit	IGM BIOSCIENCES INC	$0	–	-2,450,000	–	-2.38%	–
CERE	Exit	CEREVEL THERAPEUTICS HLDNG I	$0	–	-2,000,000	–	-2.41%	–
WW	Exit	WW INTL INC	$0	–	-14,818,300	–	-2.48%	–
FATE	Exit	FATE THERAPEUTICS INC	$0	–	-2,600,000	–	-2.49%	–
SWTX	Exit	SPRINGWORKS THERAPEUTICS INC	$0	–	-2,053,403	–	-2.50%	–
SRRK	Exit	SCHOLAR ROCK HLDG CORP	$0	–	-8,750,034	–	-2.59%	–
MORF	Exit	MORPHIC HLDG INC	$0	–	-2,150,000	–	-2.60%	–
BLU	Exit	BELLUS HEALTH INC NEW	$0	–	-6,000,000	–	-2.70%	–
APLS	Exit	APELLIS PHARMACEUTICALS INC	$0	–	-1,000,000	–	-2.92%	–
BGNE	Exit	BEIGENE LTDsponsored adr	$0	–	-650,000	–	-3.74%	–
MRTX	Exit	MIRATI THERAPEUTICS INC	$0	–	-1,325,000	–	-3.95%	–
LXRX	Exit	LEXICON PHARMACEUTICALS INC	$0	–	-89,778,234	–	-9.20%	–
XBI	Exit	SPDR SER TRcall	$0	–	-5,000,000	–	-16.93%	–

Q3 2022

			Value		Shares		↓ Weighting
XBI	New	SPDR SER TRcall	$396,600,000	–	5,000,000	–	16.93%	–
LXRX	Buy	LEXICON PHARMACEUTICALS INC	$215,468,000	+62.8%	89,778,234	+26.1%	9.20%	+30.1%
MRTX	Buy	MIRATI THERAPEUTICS INC	$92,538,000	+25.3%	1,325,000	+20.5%	3.95%	+0.1%
APLS	New	APELLIS PHARMACEUTICALS INC	$68,300,000	–	1,000,000	–	2.92%	–
BLU	Sell	BELLUS HEALTH INC NEW	$63,360,000	-2.0%	6,000,000	-14.3%	2.70%	-21.7%
MORF	Buy	MORPHIC HLDG INC	$60,845,000	+69.9%	2,150,000	+30.3%	2.60%	+35.8%
SWTX	Buy	SPRINGWORKS THERAPEUTICS INC	$58,584,000	+164.4%	2,053,403	+128.2%	2.50%	+111.3%
CERE	Buy	CEREVEL THERAPEUTICS HLDNG I	$56,520,000	+42.5%	2,000,000	+33.3%	2.41%	+13.9%
IGMS	Buy	IGM BIOSCIENCES INC	$55,713,000	+54.5%	2,450,000	+22.5%	2.38%	+23.5%
ARGX	Sell	ARGENX SEsponsored adr	$52,958,000	-65.1%	150,000	-62.5%	2.26%	-72.1%
CYTK	Sell	CYTOKINETICS INC	$48,450,000	-3.3%	1,000,000	-21.6%	2.07%	-22.7%
SGEN	Sell	SEAGEN INC	$47,891,000	-48.4%	350,000	-33.3%	2.04%	-58.8%
ALVR	Buy	ALLOVIR INC	$44,004,000	+385.6%	5,577,167	+140.0%	1.88%	+288.0%
GOSS	Buy	GOSSAMER BIO INC	$38,895,000	+97.0%	3,246,624	+37.6%	1.66%	+57.3%
KYMR	Buy	KYMERA THERAPEUTICS INC	$32,655,000	+65.8%	1,500,000	+50.0%	1.39%	+32.5%
RLAY	Buy	RELAY THERAPEUTICS INC	$32,542,000	+177.5%	1,454,716	+107.8%	1.39%	+121.9%
SAGE	Buy	SAGE THERAPEUTICS INC	$29,370,000	+102.1%	750,000	+66.7%	1.25%	+61.5%
KRTX	New	KARUNA THERAPEUTICS INC	$28,116,000	–	125,000	–	1.20%	–
	Buy	VIGIL NEUROSCIENCE INC	$20,799,000	+618.9%	2,285,574	+103.9%	0.89%	+472.9%
KURA	Buy	KURA ONCOLOGY INC	$15,026,000	-21.9%	1,100,000	+4.8%	0.64%	-37.6%
SGEN	New	SEAGEN INCcall	$13,683,000	–	100,000	–	0.58%	–
ISEE	New	IVERIC BIO INC	$13,455,000	–	750,000	–	0.57%	–
SE	Buy	SEA LTDsponsored ads	$9,669,000	+151.5%	172,500	+200.0%	0.41%	+101.5%
	New	SYROS PHARMACEUTICALS INC	$9,427,000	–	1,463,829	–	0.40%	–
ISEE	New	IVERIC BIO INCcall	$8,970,000	–	500,000	–	0.38%	–
ALPN	Buy	ALPINE IMMUNE SCIENCES INC	$8,590,000	+70.2%	1,193,030	+101.2%	0.37%	+35.9%
AGEN	Buy	AGENUS INC	$8,200,000	+40.9%	4,000,000	+33.3%	0.35%	+12.5%
BGNE	New	BEIGENE LTDcall	$6,741,000	–	50,000	–	0.29%	–
NTRA	New	NATERA INC	$4,382,000	–	100,000	–	0.19%	–
CNCE	New	CONCERT PHARMACEUTICALS INC	$3,840,000	–	573,062	–	0.16%	–
	New	THIRD HARMONIC BIO INC	$3,794,000	–	200,000	–	0.16%	–
	New	MINERVA NEUROSCIENCES INC	$2,308,000	–	250,000	–	0.10%	–
YI	Sell	111 INCads	$1,840,000	-7.6%	686,431	-29.0%	0.08%	-25.5%
	Sell	MARINUS PHARMACEUTICALS INC	$1,044,000	-78.4%	157,000	-84.3%	0.04%	-82.6%
AVTR	New	AVANTOR INC	$882,000	–	45,000	–	0.04%	–
RUBY	Sell	RUBIUS THERAPEUTICS INC	$886,000	-71.9%	2,042,666	-44.8%	0.04%	-77.4%
	New	HIPPO HLDGS INC	$445,000	–	24,000	–	0.02%	–
ADBE	New	ADOBE SYSTEMS INCORPORATED	$358,000	–	1,300	–	0.02%	–
KLDO	Exit	KALEIDO BIOSCIENCES INC	$0	–	-500,500	–	-0.00%	–
	Exit	BATH & BODY WORKS INC	$0	–	-12,500	–	-0.02%	–
UNG	Exit	UNITED STS NAT GAS FD LPunit par	$0	–	-20,000	–	-0.02%	–
CLF	Exit	CLEVELAND-CLIFFS INC NEW	$0	–	-25,000	–	-0.02%	–
	Exit	HIPPO HLDGS INC	$0	–	-600,000	–	-0.03%	–
	Exit	AMYLYX PHARMACEUTICALS INC	$0	–	-75,000	–	-0.08%	–
	Exit	CINCOR PHARMA INC	$0	–	-137,010	–	-0.14%	–
	Exit	ADAGIO THERAPEUTICS INC	$0	–	-1,000,000	–	-0.18%	–
ADVM	Exit	ADVERUM BIOTECHNOLOGIES INC	$0	–	-3,000,000	–	-0.19%	–
SYRS	Exit	SYROS PHARMACEUTICALS INC	$0	–	-4,000,000	–	-0.21%	–
DSGN	Exit	DESIGN THERAPEUTICS INC	$0	–	-400,000	–	-0.30%	–
ATRA	Exit	ATARA BIOTHERAPEUTICS INC	$0	–	-1,000,000	–	-0.42%	–
LABU	Exit	DIREXION SHS ETF TRcall	$0	–	-4,000,000	–	-1.44%	–
C	Exit	CITIGROUP INCcall	$0	–	-1,000,000	–	-2.46%	–
ALNY	Exit	ALNYLAM PHARMACEUTICALS INC	$0	–	-600,000	–	-4.67%	–

Q2 2022

			Value		Shares		↓ Weighting
ARGX	New	ARGENX SEsponsored adr	$151,552,000	–	400,000	–	8.10%	–
LXRX	New	LEXICON PHARMACEUTICALS INC	$132,392,000	–	71,178,364	–	7.07%	–
BGNE	New	BEIGENE LTDsponsored adr	$105,203,000	–	650,000	–	5.62%	–
WW	New	WW INTL INC	$94,689,000	–	14,818,300	–	5.06%	–
SGEN	New	SEAGEN INC	$92,894,000	–	525,000	–	4.96%	–
ALNY	New	ALNYLAM PHARMACEUTICALS INC	$87,510,000	–	600,000	–	4.67%	–
MRTX	New	MIRATI THERAPEUTICS INC	$73,843,000	–	1,100,000	–	3.94%	–
BLU	New	BELLUS HEALTH INC NEW	$64,680,000	–	7,000,000	–	3.46%	–
FATE	New	FATE THERAPEUTICS INC	$64,428,000	–	2,600,000	–	3.44%	–
CYTK	New	CYTOKINETICS INC	$50,095,000	–	1,275,000	–	2.68%	–
SRRK	New	SCHOLAR ROCK HLDG CORP	$48,038,000	–	8,750,034	–	2.57%	–
C	New	CITIGROUP INCcall	$45,990,000	–	1,000,000	–	2.46%	–
FOLD	New	AMICUS THERAPEUTICS INC	$42,960,000	–	4,000,000	–	2.30%	–
SEER	New	SEER INC	$42,513,000	–	4,750,000	–	2.27%	–
CERE	New	CEREVEL THERAPEUTICS HLDNG I	$39,660,000	–	1,500,000	–	2.12%	–
IGMS	New	IGM BIOSCIENCES INC	$36,060,000	–	2,000,000	–	1.93%	–
MORF	New	MORPHIC HLDG INC	$35,805,000	–	1,650,000	–	1.91%	–
KRYS	New	KRYSTAL BIOTECH INC	$32,830,000	–	500,000	–	1.75%	–
LABU	New	DIREXION SHS ETF TRcall	$26,960,000	–	4,000,000	–	1.44%	–
FHTX	New	FOGHORN THERAPEUTICS INC	$23,402,000	–	1,720,720	–	1.25%	–
SWTX	New	SPRINGWORKS THERAPEUTICS INC	$22,158,000	–	900,000	–	1.18%	–
GOSS	New	GOSSAMER BIO INC	$19,745,000	–	2,358,968	–	1.06%	–
KYMR	New	KYMERA THERAPEUTICS INC	$19,690,000	–	1,000,000	–	1.05%	–
KURA	New	KURA ONCOLOGY INC	$19,247,000	–	1,050,000	–	1.03%	–
	New	EQRX INC	$18,760,000	–	4,000,000	–	1.00%	–
SDGR	New	SCHRODINGER INC	$18,487,000	–	700,000	–	0.99%	–
GBIO	New	GENERATION BIO CO	$18,461,000	–	2,814,191	–	0.99%	–
	New	ERASCA INC	$17,669,000	–	3,172,221	–	0.94%	–
DNLI	New	DENALI THERAPEUTICS INC	$17,658,000	–	600,000	–	0.94%	–
REPL	New	REPLIMUNE GROUP INC	$15,732,000	–	900,000	–	0.84%	–
SAGE	New	SAGE THERAPEUTICS INC	$14,535,000	–	450,000	–	0.78%	–
NTLA	New	INTELLIA THERAPEUTICS INC	$14,234,000	–	275,000	–	0.76%	–
EVTCY	New	EVOTEC AGsponsored ads	$13,770,000	–	1,149,425	–	0.74%	–
RLAY	New	RELAY THERAPEUTICS INC	$11,725,000	–	700,000	–	0.63%	–
MRSN	New	MERSANA THERAPEUTICS INC	$10,164,000	–	2,200,000	–	0.54%	–
AUPH	New	AURINIA PHARMACEUTICALS INC	$10,050,000	–	1,000,000	–	0.54%	–
RPTX	New	REPARE THERAPEUTICS INC	$9,793,000	–	700,000	–	0.52%	–
WVE	New	WAVE LIFE SCIENCES LTD	$9,750,000	–	3,000,000	–	0.52%	–
IMAB	New	I MABsponsored ads	$9,605,000	–	850,000	–	0.51%	–
TALS	New	TALARIS THERAPEUTICS INC	$9,310,000	–	2,064,262	–	0.50%	–
ALVR	New	ALLOVIR INC	$9,061,000	–	2,323,371	–	0.48%	–
	New	OMEGA THERAPEUTICS INC	$8,639,000	–	2,273,530	–	0.46%	–
ITOS	New	ITEOS THERAPEUTICS INC	$8,240,000	–	400,000	–	0.44%	–
ATRA	New	ATARA BIOTHERAPEUTICS INC	$7,790,000	–	1,000,000	–	0.42%	–
OMEG	New	OMEGA ALPHA SPACcl a	$7,388,000	–	750,000	–	0.40%	–
IKNA	New	IKENA ONCOLOGY INC	$6,864,000	–	1,549,513	–	0.37%	–
SELB	New	SELECTA BIOSCIENCES INC	$6,397,000	–	4,883,200	–	0.34%	–
VERV	New	VERVE THERAPEUTICS INC	$6,112,000	–	400,000	–	0.33%	–
YMAB	New	Y-MABS THERAPEUTICS INC	$6,052,000	–	400,000	–	0.32%	–
	New	EXSCIENTIA PLCads	$5,990,000	–	550,000	–	0.32%	–
AGEN	New	AGENUS INC	$5,820,000	–	3,000,000	–	0.31%	–
AMAM	New	AMBRX BIOPHARMA INCsponsored ads	$5,704,000	–	2,152,291	–	0.30%	–
ACHL	New	ACHILLES THERAPEUTICS PLCsponsored ads	$5,684,000	–	2,255,375	–	0.30%	–
KRON	New	KRONOS BIO INC	$5,616,000	–	1,542,954	–	0.30%	–
DSGN	New	DESIGN THERAPEUTICS INC	$5,600,000	–	400,000	–	0.30%	–
OVID	New	OVID THERAPEUTICS INC	$5,375,000	–	2,500,000	–	0.29%	–
OTLY	New	OATLY GROUP ABsponsored ads	$5,190,000	–	1,500,000	–	0.28%	–
SQZ	New	SQZ BIOTECHNOLOGIES CO	$5,108,000	–	1,606,309	–	0.27%	–
ALPN	New	ALPINE IMMUNE SCIENCES INC	$5,047,000	–	593,030	–	0.27%	–
	New	MARINUS PHARMACEUTICALS INC	$4,840,000	–	1,000,000	–	0.26%	–
CFRX	New	CONTRAFECT CORP	$4,605,000	–	1,500,000	–	0.25%	–
LPTX	New	LEAP THERAPEUTICS INC	$4,600,000	–	4,000,000	–	0.25%	–
LYEL	New	LYELL IMMUNOPHARMA INC	$4,564,000	–	700,000	–	0.24%	–
ALXO	New	ALX ONCOLOGY HLDGS INC	$4,045,000	–	500,000	–	0.22%	–
BDTX	New	BLACK DIAMOND THERAPEUTICS I	$4,050,000	–	1,646,517	–	0.22%	–
TSHA	New	TAYSHA GENE THERAPIES INC	$3,872,000	–	1,040,882	–	0.21%	–
SYRS	New	SYROS PHARMACEUTICALS INC	$3,851,000	–	4,000,000	–	0.21%	–
SE	New	SEA LTDsponsored ads	$3,844,000	–	57,500	–	0.20%	–
NBTX	New	NANOBIOTIXsponsored ads	$3,800,000	–	1,000,000	–	0.20%	–
	New	PORTAGE FINTECH ACQUISITN CO	$3,705,000	–	380,000	–	0.20%	–
RXRX	New	RECURSION PHARMACEUTICALS INcl a	$3,663,000	–	450,000	–	0.20%	–
RNA	New	AVIDITY BIOSCIENCES INC	$3,633,000	–	250,000	–	0.19%	–
ACIU	New	AC IMMUNE SA	$3,610,000	–	1,000,000	–	0.19%	–
DYN	New	DYNE THERAPEUTICS INC	$3,607,000	–	525,000	–	0.19%	–
ADVM	New	ADVERUM BIOTECHNOLOGIES INC	$3,600,000	–	3,000,000	–	0.19%	–
APTX	New	APTINYX INC	$3,412,000	–	6,116,493	–	0.18%	–
STOK	New	STOKE THERAPEUTICS INC	$3,303,000	–	250,000	–	0.18%	–
	New	ADAGIO THERAPEUTICS INC	$3,280,000	–	1,000,000	–	0.18%	–
CGEM	New	CULLINAN ONCOLOGY INC	$3,205,000	–	250,000	–	0.17%	–
RUBY	New	RUBIUS THERAPEUTICS INC	$3,149,000	–	3,701,580	–	0.17%	–
HOOK	New	HOOKIPA PHARMA INC	$3,015,000	–	1,849,616	–	0.16%	–
PRAX	New	PRAXIS PRECISION MEDICINES I	$2,940,000	–	1,200,000	–	0.16%	–
	New	VIGIL NEUROSCIENCE INC	$2,893,000	–	1,121,191	–	0.16%	–
	New	MIRION TECHNOLOGIES INC	$2,880,000	–	500,000	–	0.15%	–
VOR	New	VOR BIOPHARMA INC	$2,734,000	–	550,000	–	0.15%	–
	New	CINCOR PHARMA INC	$2,581,000	–	137,010	–	0.14%	–
SANA	New	SANA BIOTECHNOLOGY INC	$2,572,000	–	400,000	–	0.14%	–
IMUX	New	IMMUNIC INC	$2,429,000	–	700,000	–	0.13%	–
ZYME	New	ZYMEWORKS INC	$2,385,000	–	450,000	–	0.13%	–
BBIO	New	BRIDGEBIO PHARMA INC	$2,270,000	–	250,000	–	0.12%	–
TCRR	New	TCR2 THERAPEUTICS INC	$2,175,000	–	750,000	–	0.12%	–
	New	SENTI BIOSCIENCES INC	$2,074,000	–	1,055,555	–	0.11%	–
TIL	New	INSTIL BIO INC	$2,079,000	–	450,000	–	0.11%	–
ADAG	New	ADAGENE INCads	$2,066,000	–	1,000,000	–	0.11%	–
IMMP	New	IMMUTEP LTDsponsored ads	$2,030,000	–	1,000,000	–	0.11%	–
YI	New	111 INCads	$1,991,000	–	966,349	–	0.11%	–
NEXI	New	NEXIMMUNE INC	$1,932,000	–	1,200,000	–	0.10%	–
GRPH	New	GRAPHITE BIO INC	$1,925,000	–	700,000	–	0.10%	–
HARP	New	HARPOON THERAPEUTICS INC	$1,910,000	–	1,000,000	–	0.10%	–
FUSN	New	FUSION PHARMACEUTICALS INC	$1,868,000	–	750,000	–	0.10%	–
SLDB	New	SOLID BIOSCIENCES INC	$1,847,000	–	3,000,000	–	0.10%	–
GRTS	New	GRITSTONE BIO INC	$1,815,000	–	750,000	–	0.10%	–
ORIC	New	ORIC PHARMACEUTICALS INC	$1,792,000	–	400,000	–	0.10%	–
MREO	New	MEREO BIOPHARMA GROUP PLCads	$1,680,000	–	1,500,000	–	0.09%	–
ME	New	23ANDME HOLDING CO	$1,639,000	–	661,009	–	0.09%	–
CRDF	New	CARDIFF ONCOLOGY INC	$1,650,000	–	750,000	–	0.09%	–
KNTE	New	KINNATE BIOPHARMA INC	$1,576,000	–	125,000	–	0.08%	–
CYCN	New	CYCLERION THERAPEUTICS INC	$1,525,000	–	2,779,122	–	0.08%	–
	New	AMYLYX PHARMACEUTICALS INC	$1,445,000	–	75,000	–	0.08%	–
AXLA	New	AXCELLA HEALTH INC	$1,446,000	–	712,500	–	0.08%	–
	New	XILIO THERAPEUTICS INC	$1,314,000	–	450,000	–	0.07%	–
ARAV	New	ARAVIVE INC	$1,295,000	–	1,311,291	–	0.07%	–
IRWD	New	IRONWOOD PHARMACEUTICALS INC	$1,274,000	–	110,532	–	0.07%	–
CRIS	New	CURIS INC	$1,280,000	–	1,300,000	–	0.07%	–
OLMA	New	OLEMA PHARMACEUTICALS INC	$1,060,000	–	260,500	–	0.06%	–
ORTX	New	ORCHARD THERAPEUTICS PLCads	$1,054,000	–	1,803,858	–	0.06%	–
IGMS	New	IGM BIOSCIENCES INCcall	$902,000	–	50,000	–	0.05%	–
LVTX	New	LAVA THERAPEUTICS NV	$590,000	–	200,000	–	0.03%	–
MEIP	New	MEI PHARMA INC	$605,000	–	1,000,000	–	0.03%	–
	New	CARIBOU BIOSCIENCES INC	$572,000	–	105,347	–	0.03%	–
CDAK	New	CODIAK BIOSCIENCES INC	$576,000	–	200,000	–	0.03%	–
	New	HIPPO HLDGS INC	$527,000	–	600,000	–	0.03%	–
CRVS	New	CORVUS PHARMACEUTICALS INC	$495,000	–	500,000	–	0.03%	–
MTCR	New	METACRINE INC	$462,000	–	924,898	–	0.02%	–
	New	MINK THERAPEUTICS INC	$408,000	–	289,588	–	0.02%	–
YMTX	New	YUMANITY THERAPEUTICS INC	$396,000	–	217,391	–	0.02%	–
CLF	New	CLEVELAND-CLIFFS INC NEW	$384,000	–	25,000	–	0.02%	–
APLT	New	APPLIED THERAPEUTICS INC	$379,000	–	400,000	–	0.02%	–
UNG	New	UNITED STS NAT GAS FD LPunit par	$380,000	–	20,000	–	0.02%	–
SPRO	New	SPERO THERAPEUTICS INC	$371,000	–	500,000	–	0.02%	–
	New	BATH & BODY WORKS INC	$337,000	–	12,500	–	0.02%	–
SGTX	New	SIGILON THERAPEUTICS INC	$229,000	–	276,000	–	0.01%	–
CDTX	New	CIDARA THERAPEUTICS INC	$110,000	–	224,675	–	0.01%	–
	New	ASTRIA THERAPEUTICS INC	$100,000	–	33,333	–	0.01%	–
KLDO	New	KALEIDO BIOSCIENCES INC	$31,000	–	500,500	–	0.00%	–

Q4 2021

			Value		Shares		↓ Weighting
EQT	Exit	EQT CORP	$0	–	-9,678	–	-0.00%	–
	Exit	ASTRIA THERAPEUTICS INC	$0	–	-33,333	–	-0.01%	–
CDTX	Exit	CIDARA THERAPEUTICS INC	$0	–	-224,675	–	-0.01%	–
ATUS	Exit	ALTICE USA INCcl a	$0	–	-27,000	–	-0.01%	–
SURF	Exit	SURFACE ONCOLOGY INC	$0	–	-100,000	–	-0.02%	–
RIGL	Exit	RIGEL PHARMACEUTICALS INC	$0	–	-321,100	–	-0.03%	–
LVTX	Exit	LAVA THERAPEUTICS NV	$0	–	-200,000	–	-0.03%	–
IRWD	Exit	IRONWOOD PHARMACEUTICALS INC	$0	–	-110,532	–	-0.03%	–
SGTX	Exit	SIGILON THERAPEUTICS INC	$0	–	-276,000	–	-0.04%	–
AMYT	Exit	AMRYT PHARMA PLCsponsored ads	$0	–	-150,480	–	-0.04%	–
AVTR	Exit	AVANTOR INC	$0	–	-50,000	–	-0.05%	–
AXLA	Exit	AXCELLA HEALTH INC	$0	–	-712,500	–	-0.05%	–
CGEM	Exit	CULLINAN ONCOLOGY INC	$0	–	-100,000	–	-0.05%	–
YMTX	Exit	YUMANITY THERAPEUTICS INC	$0	–	-217,391	–	-0.05%	–
KDNY	Exit	CHINOOK THERAPEUTICS INC	$0	–	-180,500	–	-0.05%	–
CRVS	Exit	CORVUS PHARMACEUTICALS INC	$0	–	-500,000	–	-0.05%	–
KLDO	Exit	KALEIDO BIOSCIENCES INC	$0	–	-500,500	–	-0.06%	–
MEIP	Exit	MEI PHARMA INC	$0	–	-1,000,000	–	-0.06%	–
	Exit	HIPPO HLDGS INC	$0	–	-600,000	–	-0.06%	–
KNTE	Exit	KINNATE BIOPHARMA INC	$0	–	-125,000	–	-0.06%	–
MTCR	Exit	METACRINE INC	$0	–	-924,898	–	-0.07%	–
CDAK	Exit	CODIAK BIOSCIENCES INC	$0	–	-200,000	–	-0.07%	–
DCPH	Exit	DECIPHERA PHARMACEUTICALS IN	$0	–	-100,000	–	-0.08%	–
RNA	Exit	AVIDITY BIOSCIENCES INC	$0	–	-142,500	–	-0.08%	–
HOOK	Exit	HOOKIPA PHARMA INC	$0	–	-599,616	–	-0.08%	–
MREO	Exit	MEREO BIOPHARMA GROUP PLCads	$0	–	-1,500,000	–	-0.08%	–
	Exit	PORTAGE FINTECH ACQUISITN CO	$0	–	-380,000	–	-0.08%	–
IMMP	Exit	IMMUTEP LTDsponsored ads	$0	–	-1,000,000	–	-0.09%	–
ORTX	Exit	ORCHARD THERAPEUTICS PLCads	$0	–	-1,803,858	–	-0.09%	–
RXRX	Exit	RECURSION PHARMACEUTICALS INcl a	$0	–	-200,000	–	-0.10%	–
ARAV	Exit	ARAVIVE INC	$0	–	-1,311,291	–	-0.11%	–
WVE	Exit	WAVE LIFE SCIENCES LTD	$0	–	-1,000,000	–	-0.11%	–
DYNS	Exit	DYNAMICS SPECIAL PURPOSE COR	$0	–	-500,000	–	-0.11%	–
CRDF	Exit	CARDIFF ONCOLOGY INC	$0	–	-750,000	–	-0.11%	–
	Exit	OLAPLEX HLDGS INC	$0	–	-225,000	–	-0.12%	–
GDS	Exit	GDS HLDGS LTDsponsored ads	$0	–	-100,000	–	-0.13%	–
DSGN	Exit	DESIGN THERAPEUTICS INC	$0	–	-400,000	–	-0.13%	–
YI	Exit	111 INCads	$0	–	-966,349	–	-0.13%	–
FUSN	Exit	FUSION PHARMACEUTICALS INC	$0	–	-750,000	–	-0.13%	–
CFRX	Exit	CONTRAFECT CORP	$0	–	-1,500,000	–	-0.14%	–
IMUX	Exit	IMMUNIC INC	$0	–	-700,000	–	-0.14%	–
STOK	Exit	STOKE THERAPEUTICS INC	$0	–	-250,000	–	-0.14%	–
ALPN	Exit	ALPINE IMMUNE SCIENCES INC	$0	–	-593,030	–	-0.14%	–
TCRR	Exit	TCR2 THERAPEUTICS INC	$0	–	-750,000	–	-0.14%	–
ADVM	Exit	ADVERUM BIOTECHNOLOGIES INC	$0	–	-3,000,000	–	-0.15%	–
APLT	Exit	APPLIED THERAPEUTICS INC	$0	–	-400,000	–	-0.15%	–
ACIU	Exit	AC IMMUNE SA	$0	–	-1,000,000	–	-0.15%	–
EVLO	Exit	EVELO BIOSCIENCES INC	$0	–	-1,000,000	–	-0.16%	–
SLDB	Exit	SOLID BIOSCIENCES INC	$0	–	-3,000,000	–	-0.16%	–
OLMA	Exit	OLEMA PHARMACEUTICALS INC	$0	–	-260,500	–	-0.16%	–
OMEG	Exit	OMEGA ALPHA SPACcl a	$0	–	-750,000	–	-0.16%	–
IMCR	Exit	IMMUNOCORE HLDGS PLCads	$0	–	-200,000	–	-0.17%	–
HARP	Exit	HARPOON THERAPEUTICS INC	$0	–	-1,000,000	–	-0.18%	–
TIL	Exit	INSTIL BIO INC	$0	–	-450,000	–	-0.18%	–
IQ	Exit	IQIYI INCsponsored ads	$0	–	-1,000,000	–	-0.18%	–
AGLE	Exit	AEGLEA BIOTHERAPEUTICS INC	$0	–	-1,045,000	–	-0.19%	–
ORIC	Exit	ORIC PHARMACEUTICALS INC	$0	–	-400,000	–	-0.19%	–
OVID	Exit	OVID THERAPEUTICS INC	$0	–	-2,500,000	–	-0.19%	–
CYCN	Exit	CYCLERION THERAPEUTICS INC	$0	–	-2,779,122	–	-0.19%	–
DYN	Exit	DYNE THERAPEUTICS INC	$0	–	-525,000	–	-0.19%	–
VOR	Exit	VOR BIOPHARMA INC	$0	–	-550,000	–	-0.19%	–
SYRS	Exit	SYROS PHARMACEUTICALS INC	$0	–	-2,000,000	–	-0.20%	–
SANA	Exit	SANA BIOTECHNOLOGY INC	$0	–	-400,000	–	-0.20%	–
SPRO	Exit	SPERO THERAPEUTICS INC	$0	–	-500,000	–	-0.21%	–
	Exit	CARIBOU BIOSCIENCES INC	$0	–	-405,347	–	-0.22%	–
CRIS	Exit	CURIS INC	$0	–	-1,300,000	–	-0.23%	–
BPMC	Exit	BLUEPRINT MEDICINES CORP	$0	–	-100,000	–	-0.23%	–
LYEL	Exit	LYELL IMMUNOPHARMA INC	$0	–	-700,000	–	-0.23%	–
MRSN	Exit	MERSANA THERAPEUTICS INC	$0	–	-1,200,000	–	-0.25%	–
NBTX	Exit	NANOBIOTIX SAsponsored ads	$0	–	-1,000,000	–	-0.25%	–
YMAB	Exit	Y-MABS THERAPEUTICS INC	$0	–	-400,000	–	-0.26%	–
	Exit	MARINUS PHARMACEUTICALS INC	$0	–	-1,000,000	–	-0.26%	–
GRPH	Exit	GRAPHITE BIO INC	$0	–	-700,000	–	-0.26%	–
AMAM	Exit	AMBRX BIOPHARMA INCsponsored ads	$0	–	-850,000	–	-0.26%	–
BBIO	Exit	BRIDGEBIO PHARMA INC	$0	–	-250,000	–	-0.26%	–
RLAY	Exit	RELAY THERAPEUTICS INC	$0	–	-400,000	–	-0.28%	–
ZYME	Exit	ZYMEWORKS INC	$0	–	-450,000	–	-0.29%	–
BDTX	Exit	BLACK DIAMOND THERAPEUTICS I	$0	–	-1,646,517	–	-0.31%	–
DRNA	Exit	DICERNA PHARMACEUTICALS INC	$0	–	-700,000	–	-0.32%	–
APTX	Exit	APTINYX INC	$0	–	-6,116,493	–	-0.32%	–
ADAG	Exit	ADAGENE INCads	$0	–	-1,000,000	–	-0.32%	–
RPTX	Exit	REPARE THERAPEUTICS INC	$0	–	-550,000	–	-0.32%	–
BABA	Exit	ALIBABA GROUP HLDG LTDsponsored ads	$0	–	-100,000	–	-0.33%	–
INTC	Exit	INTEL CORPcall	$0	–	-300,000	–	-0.36%	–
LPTX	Exit	LEAP THERAPEUTICS INC	$0	–	-4,000,000	–	-0.36%	–
SELB	Exit	SELECTA BIOSCIENCES INC	$0	–	-4,000,000	–	-0.37%	–
ACHL	Exit	ACHILLES THERAPEUTICS PLCsponsored ads	$0	–	-2,255,375	–	-0.39%	–
NG	Exit	NOVAGOLD RES INC	$0	–	-2,600,000	–	-0.40%	–
NEXI	Exit	NEXIMMUNE INC	$0	–	-1,200,000	–	-0.41%	–
ALBO	Exit	ALBIREO PHARMA INC	$0	–	-600,000	–	-0.42%	–
VERV	Exit	VERVE THERAPEUTICS INC	$0	–	-400,000	–	-0.42%	–
TSHA	Exit	TAYSHA GENE THERAPIES INC	$0	–	-1,040,882	–	-0.43%	–
IKNA	Exit	IKENA ONCOLOGY INC	$0	–	-1,549,513	–	-0.44%	–
KURA	Exit	KURA ONCOLOGY INC	$0	–	-1,050,000	–	-0.44%	–
AUPH	Exit	AURINIA PHARMACEUTICALS INC	$0	–	-1,000,000	–	-0.50%	–
PRAX	Exit	PRAXIS PRECISION MEDICINES I	$0	–	-1,200,000	–	-0.50%	–
OTLY	Exit	OATLY GROUP ABsponsored ads	$0	–	-1,500,000	–	-0.51%	–
SQZ	Exit	SQZ BIOTECHNOLOGIES CO	$0	–	-1,606,309	–	-0.52%	–
FMTX	Exit	FORMA THERAPEUTICS HLDGS INC	$0	–	-1,000,000	–	-0.52%	–
TPTX	Exit	TURNING POINT THERAPEUTICS I	$0	–	-350,000	–	-0.52%	–
KYMR	Exit	KYMERA THERAPEUTICS INC	$0	–	-400,000	–	-0.53%	–
FHTX	Exit	FOGHORN THERAPEUTICS INC	$0	–	-1,720,720	–	-0.54%	–
DNLI	Exit	DENALI THERAPEUTICS INC	$0	–	-500,000	–	-0.56%	–
KRYS	Exit	KRYSTAL BIOTECH INC	$0	–	-500,000	–	-0.58%	–
PTGX	Exit	PROTAGONIST THERAPEUTICS INC	$0	–	-1,500,000	–	-0.60%	–
TGTX	Exit	TG THERAPEUTICS INC	$0	–	-800,000	–	-0.60%	–
REPL	Exit	REPLIMUNE GROUP INC	$0	–	-900,000	–	-0.60%	–
ITOS	Exit	ITEOS THERAPEUTICS INC	$0	–	-994,047	–	-0.60%	–
ATRA	Exit	ATARA BIOTHERAPEUTICS INC	$0	–	-1,500,000	–	-0.60%	–
KRON	Exit	KRONOS BIO INC	$0	–	-1,317,954	–	-0.62%	–
TALS	Exit	TALARIS THERAPEUTICS INC	$0	–	-2,064,262	–	-0.63%	–
AGEN	Exit	AGENUS INC	$0	–	-5,500,000	–	-0.65%	–
GOSS	Exit	GOSSAMER BIO INC	$0	–	-2,358,968	–	-0.66%	–
BLU	Exit	BELLUS HEALTH INC NEW	$0	–	-5,250,000	–	-0.72%	–
VRTX	Exit	VERTEX PHARMACEUTICALS INCcall	$0	–	-200,000	–	-0.81%	–
NTLA	Exit	INTELLIA THERAPEUTICS INC	$0	–	-275,000	–	-0.82%	–
ALXO	Exit	ALX ONCOLOGY HLDGS INC	$0	–	-500,000	–	-0.83%	–
MRK	Exit	MERCK & CO INCcall	$0	–	-500,000	–	-0.84%	–
SWTX	Exit	SPRINGWORKS THERAPEUTICS INC	$0	–	-600,000	–	-0.85%	–
SDGR	Exit	SCHRODINGER INC	$0	–	-700,000	–	-0.86%	–
	Exit	OMEGA THERAPEUTICS INC	$0	–	-2,273,530	–	-0.96%	–
SAGE	Exit	SAGE THERAPEUTICS INC	$0	–	-1,000,000	–	-0.99%	–
CYTK	Exit	CYTOKINETICS INC	$0	–	-1,300,000	–	-1.04%	–
CERE	Exit	CEREVEL THERAPEUTICS HLDNG I	$0	–	-1,800,000	–	-1.19%	–
ALVR	Exit	ALLOVIR INC	$0	–	-2,323,371	–	-1.30%	–
BMY	Exit	BRISTOL-MYERS SQUIBB COcall	$0	–	-1,000,000	–	-1.32%	–
IMAB	Exit	I MABsponsored ads	$0	–	-825,000	–	-1.34%	–
SGEN	Exit	SEAGEN INC	$0	–	-375,000	–	-1.42%	–
FOLD	Exit	AMICUS THERAPEUTICS INC	$0	–	-6,696,955	–	-1.43%	–
SRRK	Exit	SCHOLAR ROCK HLDG CORP	$0	–	-1,950,000	–	-1.44%	–
	Exit	ERASCA INC	$0	–	-3,172,221	–	-1.51%	–
GBIO	Exit	GENERATION BIO CO	$0	–	-2,814,191	–	-1.58%	–
RUBY	Exit	RUBIUS THERAPEUTICS INC	$0	–	-4,155,625	–	-1.66%	–
FATE	Exit	FATE THERAPEUTICS INC	$0	–	-1,450,000	–	-1.92%	–
IGMS	Exit	IGM BIOSCIENCES INC	$0	–	-1,350,000	–	-1.99%	–
MORF	Exit	MORPHIC HLDG INC	$0	–	-1,585,049	–	-2.01%	–
FCX	Exit	FREEPORT-MCMORAN INCcall	$0	–	-3,500,000	–	-2.55%	–
ALNY	Exit	ALNYLAM PHARMACEUTICALS INC	$0	–	-700,000	–	-2.96%	–
C	Exit	CITIGROUP INCcall	$0	–	-2,000,000	–	-3.14%	–
SEER	Exit	SEER INC	$0	–	-4,750,000	–	-3.67%	–
XLRN	Exit	ACCELERON PHARMA INC	$0	–	-1,000,000	–	-3.85%	–
ARGX	Exit	ARGENX SEsponsored adr	$0	–	-577,308	–	-3.90%	–
MRTX	Exit	MIRATI THERAPEUTICS INC	$0	–	-1,200,000	–	-4.75%	–
BGNE	Exit	BEIGENE LTDsponsored adr	$0	–	-650,000	–	-5.28%	–
WW	Exit	WW INTL INC	$0	–	-14,818,300	–	-6.05%	–
LXRX	Exit	LEXICON PHARMACEUTICALS INC	$0	–	-71,178,364	–	-7.66%	–

Q3 2021

			Value		Shares		↓ Weighting
BGNE	Sell	BEIGENE LTDsponsored adr	$235,950,000	-19.1%	650,000	-23.5%	5.28%	-10.8%
MRTX	Buy	MIRATI THERAPEUTICS INC	$212,292,000	+54.6%	1,200,000	+41.2%	4.75%	+70.4%
ARGX	Buy	ARGENX SEsponsored adr	$174,347,000	+15.8%	577,308	+15.5%	3.90%	+27.7%
XLRN	Sell	ACCELERON PHARMA INC	$172,100,000	-2.0%	1,000,000	-28.6%	3.85%	+8.0%
SEER	Sell	SEER INC	$164,018,000	-10.5%	4,750,000	-15.0%	3.67%	-1.3%
C	Sell	CITIGROUP INCcall	$140,360,000	-27.9%	2,000,000	-27.3%	3.14%	-20.5%
ALNY	Sell	ALNYLAM PHARMACEUTICALS INC	$132,167,000	+4.0%	700,000	-6.7%	2.96%	+14.6%
FCX	Buy	FREEPORT-MCMORAN INCcall	$113,855,000	+309.1%	3,500,000	+366.7%	2.55%	+350.8%
MORF	Sell	MORPHIC HLDG INC	$89,777,000	-14.0%	1,585,049	-12.9%	2.01%	-5.2%
IGMS	Buy	IGM BIOSCIENCES INC	$88,776,000	-3.0%	1,350,000	+22.7%	1.99%	+6.9%
FATE	Buy	FATE THERAPEUTICS INC	$85,942,000	-26.6%	1,450,000	+7.4%	1.92%	-19.1%
RUBY	Sell	RUBIUS THERAPEUTICS INC	$74,303,000	-34.3%	4,155,625	-10.3%	1.66%	-27.6%
	New	ERASCA INC	$67,315,000	–	3,172,221	–	1.51%	–
SRRK	Sell	SCHOLAR ROCK HLDG CORP	$64,389,000	+11.4%	1,950,000	-2.5%	1.44%	+22.8%
FOLD	Buy	AMICUS THERAPEUTICS INC	$63,956,000	+76.9%	6,696,955	+78.6%	1.43%	+95.0%
SGEN	New	SEAGEN INC	$63,675,000	–	375,000	–	1.42%	–
IMAB	Buy	I MABsponsored ads	$59,804,000	-5.0%	825,000	+10.0%	1.34%	+4.7%
CERE	Sell	CEREVEL THERAPEUTICS HLDNG I	$53,100,000	+3.6%	1,800,000	-10.0%	1.19%	+14.2%
CYTK	Buy	CYTOKINETICS INC	$46,462,000	+369.6%	1,300,000	+160.0%	1.04%	+417.4%
	New	OMEGA THERAPEUTICS INC	$42,856,000	–	2,273,530	–	0.96%	–
SDGR	Sell	SCHRODINGER INC	$38,276,000	-36.5%	700,000	-12.2%	0.86%	-30.1%
SWTX	Buy	SPRINGWORKS THERAPEUTICS INC	$38,064,000	-7.6%	600,000	+20.0%	0.85%	+1.9%
MRK	New	MERCK & CO INCcall	$37,555,000	–	500,000	–	0.84%	–
NTLA	Buy	INTELLIA THERAPEUTICS INC	$36,891,000	-8.9%	275,000	+10.0%	0.82%	+0.4%
VRTX	New	VERTEX PHARMACEUTICALS INCcall	$36,278,000	–	200,000	–	0.81%	–
BLU	Buy	BELLUS HEALTH INC NEW	$32,235,000	+118.2%	5,250,000	+10.5%	0.72%	+140.3%
AGEN	Sell	AGENUS INC	$28,875,000	-12.3%	5,500,000	-8.3%	0.65%	-3.4%
PTGX	New	PROTAGONIST THERAPEUTICS INC	$26,580,000	–	1,500,000	–	0.60%	–
KYMR	Buy	KYMERA THERAPEUTICS INC	$23,496,000	+93.8%	400,000	+60.0%	0.53%	+113.8%
KURA	Buy	KURA ONCOLOGY INC	$19,667,000	+57.2%	1,050,000	+75.0%	0.44%	+73.2%
VERV	Sell	VERVE THERAPEUTICS INC	$18,800,000	-37.6%	400,000	-20.0%	0.42%	-31.1%
LPTX	Buy	LEAP THERAPEUTICS INC	$16,040,000	+226.0%	4,000,000	+33.3%	0.36%	+259.0%
INTC	Sell	INTEL CORPcall	$15,984,000	-78.1%	300,000	-76.9%	0.36%	-75.8%
BABA	New	ALIBABA GROUP HLDG LTDsponsored ads	$14,805,000	–	100,000	–	0.33%	–
DRNA	Sell	DICERNA PHARMACEUTICALS INC	$14,112,000	-52.7%	700,000	-12.5%	0.32%	-47.9%
BBIO	Sell	BRIDGEBIO PHARMA INC	$11,718,000	-30.1%	250,000	-9.1%	0.26%	-22.9%
	New	CARIBOU BIOSCIENCES INC	$9,676,000	–	405,347	–	0.22%	–
SYRS	Buy	SYROS PHARMACEUTICALS INC	$8,940,000	-3.5%	2,000,000	+17.6%	0.20%	+6.4%
SLDB	Buy	SOLID BIOSCIENCES INC	$7,170,000	-12.9%	3,000,000	+33.3%	0.16%	-4.2%
GDS	New	GDS HLDGS LTDsponsored ads	$5,661,000	–	100,000	–	0.13%	–
	New	OLAPLEX HLDGS INC	$5,513,000	–	225,000	–	0.12%	–
WVE	New	WAVE LIFE SCIENCES LTD	$4,900,000	–	1,000,000	–	0.11%	–
	New	PORTAGE FINTECH ACQUISITN CO	$3,800,000	–	380,000	–	0.08%	–
DCPH	Sell	DECIPHERA PHARMACEUTICALS IN	$3,398,000	-53.6%	100,000	-50.0%	0.08%	-49.0%
	New	HIPPO HLDGS INC	$2,808,000	–	600,000	–	0.06%	–
CRVS	New	CORVUS PHARMACEUTICALS INC	$2,420,000	–	500,000	–	0.05%	–
AVTR	New	AVANTOR INC	$2,045,000	–	50,000	–	0.05%	–
AMYT	New	AMRYT PHARMA PLCsponsored ads	$1,813,000	–	150,480	–	0.04%	–
ATUS	New	ALTICE USA INCcl a	$559,000	–	27,000	–	0.01%	–
	New	ASTRIA THERAPEUTICS INC	$295,000	–	33,333	–	0.01%	–
EQT	New	EQT CORP	$198,000	–	9,678	–	0.00%	–
LU	Exit	LUFAX HOLDING LTD	$0	–	-50,000	–	-0.01%	–
CEREW	Exit	CEREVEL THERAPEUTICS HLDNG I*w exp 06/09/202	$0	–	-79,600	–	-0.02%	–
CHMA	Exit	CHIASMA INC	$0	–	-380,000	–	-0.04%	–
MOLN	Exit	MOLECULAR PARTNERS AGads	$0	–	-100,000	–	-0.04%	–
VIAC	Exit	VIACOMCBS INCcl b	$0	–	-75,000	–	-0.07%	–
MCRB	Exit	SERES THERAPEUTICS INC	$0	–	-200,000	–	-0.10%	–
ALDX	Exit	ALDEYRA THERAPEUTICS INC	$0	–	-431,894	–	-0.10%	–
BHG	Exit	BRIGHT HEALTH GROUP INC	$0	–	-305,555	–	-0.11%	–
AGL	Exit	AGILON HEALTH INC	$0	–	-300,000	–	-0.25%	–
TBIO	Exit	TRANSLATE BIO INC	$0	–	-500,000	–	-0.28%	–
LFST	Exit	LIFESTANCE HEALTH GROUP INC	$0	–	-500,000	–	-0.28%	–
DLO	Exit	DLOCAL LTD	$0	–	-295,000	–	-0.32%	–
CAR	Exit	AVIS BUDGET GROUP	$0	–	-300,000	–	-0.47%	–
	Exit	TRILLIUM THERAPEUTICS INC	$0	–	-2,500,000	–	-0.49%	–
BHVN	Exit	BIOHAVEN PHARMACTL HLDG CO L	$0	–	-400,000	–	-0.79%	–
F	Exit	FORD MTR CO DELcall	$0	–	-3,500,000	–	-1.06%	–
GM	Exit	GENERAL MTRS COcall	$0	–	-2,000,000	–	-2.40%	–

Q2 2021

			Value		Shares		↓ Weighting
WW	New	WW INTL INC	$535,533,000	–	14,818,300	–	10.87%	–
LXRX	New	LEXICON PHARMACEUTICALS INC	$326,708,000	–	71,178,364	–	6.63%	–
BGNE	New	BEIGENE LTDsponsored adr	$291,712,000	–	850,000	–	5.92%	–
C	New	CITIGROUP INCcall	$194,563,000	–	2,750,000	–	3.95%	–
SEER	New	SEER INC	$183,187,000	–	5,588,366	–	3.72%	–
XLRN	New	ACCELERON PHARMA INC	$175,686,000	–	1,400,000	–	3.57%	–
ARGX	New	ARGENX SEsponsored adr	$150,535,000	–	500,000	–	3.06%	–
MRTX	New	MIRATI THERAPEUTICS INC	$137,301,000	–	850,000	–	2.79%	–
ALNY	New	ALNYLAM PHARMACEUTICALS INC	$127,140,000	–	750,000	–	2.58%	–
GM	New	GENERAL MTRS COcall	$118,340,000	–	2,000,000	–	2.40%	–
FATE	New	FATE THERAPEUTICS INC	$117,167,000	–	1,350,000	–	2.38%	–
RUBY	New	RUBIUS THERAPEUTICS INC	$113,111,000	–	4,633,791	–	2.30%	–
MORF	New	MORPHIC HLDG INC	$104,403,000	–	1,819,186	–	2.12%	–
IGMS	New	IGM BIOSCIENCES INC	$91,520,000	–	1,100,000	–	1.86%	–
GBIO	New	GENERATION BIO CO	$75,702,000	–	2,814,191	–	1.54%	–
INTC	New	INTEL CORPcall	$72,982,000	–	1,300,000	–	1.48%	–
BMY	New	BRISTOL-MYERS SQUIBB COcall	$66,820,000	–	1,000,000	–	1.36%	–
IMAB	New	I MABsponsored ads	$62,963,000	–	750,000	–	1.28%	–
SDGR	New	SCHRODINGER INC	$60,295,000	–	797,445	–	1.22%	–
SRRK	New	SCHOLAR ROCK HLDG CORP	$57,800,000	–	2,000,000	–	1.17%	–
SAGE	New	SAGE THERAPEUTICS INC	$56,810,000	–	1,000,000	–	1.15%	–
F	New	FORD MTR CO DELcall	$52,010,000	–	3,500,000	–	1.06%	–
CERE	New	CEREVEL THERAPEUTICS HLDNG I	$51,240,000	–	2,000,000	–	1.04%	–
ALVR	New	ALLOVIR INC	$45,863,000	–	2,323,371	–	0.93%	–
SWTX	New	SPRINGWORKS THERAPEUTICS INC	$41,205,000	–	500,000	–	0.84%	–
NTLA	New	INTELLIA THERAPEUTICS INC	$40,478,000	–	250,000	–	0.82%	–
DNLI	New	DENALI THERAPEUTICS INC	$39,220,000	–	500,000	–	0.80%	–
BHVN	New	BIOHAVEN PHARMACTL HLDG CO L	$38,832,000	–	400,000	–	0.79%	–
OTLY	New	OATLY GROUP ABsponsored ads	$36,690,000	–	1,500,000	–	0.74%	–
FOLD	New	AMICUS THERAPEUTICS INC	$36,150,000	–	3,750,000	–	0.73%	–
REPL	New	REPLIMUNE GROUP INC	$34,578,000	–	900,000	–	0.70%	–
KRYS	New	KRYSTAL BIOTECH INC	$34,000,000	–	500,000	–	0.69%	–
AGEN	New	AGENUS INC	$32,940,000	–	6,000,000	–	0.67%	–
KRON	New	KRONOS BIO INC	$31,565,000	–	1,317,954	–	0.64%	–
TGTX	New	TG THERAPEUTICS INC	$31,032,000	–	800,000	–	0.63%	–
TALS	New	TALARIS THERAPEUTICS INC	$30,324,000	–	2,064,262	–	0.62%	–
VERV	New	VERVE THERAPEUTICS INC	$30,125,000	–	500,000	–	0.61%	–
DRNA	New	DICERNA PHARMACEUTICALS INC	$29,856,000	–	800,000	–	0.61%	–
FCX	New	FREEPORT-MCMORAN INCcall	$27,833,000	–	750,000	–	0.56%	–
ALXO	New	ALX ONCOLOGY HLDGS INC	$27,340,000	–	500,000	–	0.56%	–
TPTX	New	TURNING POINT THERAPEUTICS I	$27,307,000	–	350,000	–	0.55%	–
ITOS	New	ITEOS THERAPEUTICS INC	$25,497,000	–	994,047	–	0.52%	–
FMTX	New	FORMA THERAPEUTICS HLDGS INC	$24,890,000	–	1,000,000	–	0.50%	–
	New	TRILLIUM THERAPEUTICS INC	$24,250,000	–	2,500,000	–	0.49%	–
CAR	New	AVIS BUDGET GROUP	$23,367,000	–	300,000	–	0.47%	–
ATRA	New	ATARA BIOTHERAPEUTICS INC	$23,325,000	–	1,500,000	–	0.47%	–
SQZ	New	SQZ BIOTECHNOLOGIES CO	$23,211,000	–	1,606,309	–	0.47%	–
TSHA	New	TAYSHA GENE THERAPIES INC	$22,067,000	–	1,040,882	–	0.45%	–
ACHL	New	ACHILLES THERAPEUTICS PLCsponsored ads	$22,080,000	–	2,255,375	–	0.45%	–
PRAX	New	PRAXIS PRECISION MEDICINES I	$21,936,000	–	1,200,000	–	0.44%	–
IKNA	New	IKENA ONCOLOGY INC	$21,755,000	–	1,549,513	–	0.44%	–
GRPH	New	GRAPHITE BIO INC	$21,511,000	–	700,000	–	0.44%	–
ALBO	New	ALBIREO PHARMA INC	$21,108,000	–	600,000	–	0.43%	–
NG	New	NOVAGOLD RES INC	$20,826,000	–	2,600,000	–	0.42%	–
BDTX	New	BLACK DIAMOND THERAPEUTICS I	$20,071,000	–	1,646,517	–	0.41%	–
NEXI	New	NEXIMMUNE INC	$19,584,000	–	1,200,000	–	0.40%	–
GOSS	New	GOSSAMER BIO INC	$19,155,000	–	2,358,968	–	0.39%	–
FHTX	New	FOGHORN THERAPEUTICS INC	$18,360,000	–	1,720,720	–	0.37%	–
	New	MARINUS PHARMACEUTICALS INC	$17,940,000	–	1,000,000	–	0.36%	–
APTX	New	APTINYX INC	$17,310,000	–	6,116,493	–	0.35%	–
RPTX	New	REPARE THERAPEUTICS INC	$17,149,000	–	550,000	–	0.35%	–
BBIO	New	BRIDGEBIO PHARMA INC	$16,764,000	–	275,000	–	0.34%	–
SELB	New	SELECTA BIOSCIENCES INC	$16,720,000	–	4,000,000	–	0.34%	–
AMAM	New	AMBRX BIOPHARMA INCsponsored ads	$16,660,000	–	850,000	–	0.34%	–
MRSN	New	MERSANA THERAPEUTICS INC	$16,296,000	–	1,200,000	–	0.33%	–
ZYME	New	ZYMEWORKS INC	$15,611,000	–	450,000	–	0.32%	–
IQ	New	IQIYI INCsponsored ads	$15,580,000	–	1,000,000	–	0.32%	–
DLO	New	DLOCAL LTD	$15,496,000	–	295,000	–	0.32%	–
BLU	New	BELLUS HEALTH INC NEW	$14,773,000	–	4,750,000	–	0.30%	–
RLAY	New	RELAY THERAPEUTICS INC	$14,636,000	–	400,000	–	0.30%	–
LFST	New	LIFESTANCE HEALTH GROUP INC	$13,930,000	–	500,000	–	0.28%	–
HARP	New	HARPOON THERAPEUTICS INC	$13,870,000	–	1,000,000	–	0.28%	–
NBTX	New	NANOBIOTIX SAsponsored ads	$13,780,000	–	1,000,000	–	0.28%	–
TBIO	New	TRANSLATE BIO INC	$13,770,000	–	500,000	–	0.28%	–
EVLO	New	EVELO BIOSCIENCES INC	$13,740,000	–	1,000,000	–	0.28%	–
ADAG	New	ADAGENE INCads	$13,560,000	–	1,000,000	–	0.28%	–
YMAB	New	Y-MABS THERAPEUTICS INC	$13,520,000	–	400,000	–	0.27%	–
AUPH	New	AURINIA PHARMACEUTICALS INC	$12,960,000	–	1,000,000	–	0.26%	–
KURA	New	KURA ONCOLOGY INC	$12,510,000	–	600,000	–	0.25%	–
TCRR	New	TCR2 THERAPEUTICS INC	$12,308,000	–	750,000	–	0.25%	–
AGL	New	AGILON HEALTH INC	$12,171,000	–	300,000	–	0.25%	–
KYMR	New	KYMERA THERAPEUTICS INC	$12,125,000	–	250,000	–	0.25%	–
LYEL	New	LYELL IMMUNOPHARMA INC	$11,368,000	–	700,000	–	0.23%	–
DYN	New	DYNE THERAPEUTICS INC	$11,046,000	–	525,000	–	0.22%	–
CYCN	New	CYCLERION THERAPEUTICS INC	$10,838,000	–	2,779,122	–	0.22%	–
ADVM	New	ADVERUM BIOTECHNOLOGIES INC	$10,500,000	–	3,000,000	–	0.21%	–
CRIS	New	CURIS INC	$10,491,000	–	1,300,000	–	0.21%	–
VOR	New	VOR BIOPHARMA INC	$10,258,000	–	550,000	–	0.21%	–
CYTK	New	CYTOKINETICS INC	$9,895,000	–	500,000	–	0.20%	–
OVID	New	OVID THERAPEUTICS INC	$9,775,000	–	2,500,000	–	0.20%	–
SYRS	New	SYROS PHARMACEUTICALS INC	$9,265,000	–	1,700,000	–	0.19%	–
BPMC	New	BLUEPRINT MEDICINES CORP	$8,796,000	–	100,000	–	0.18%	–
YI	New	111 INCads	$8,779,000	–	966,349	–	0.18%	–
TIL	New	INSTIL BIO INC	$8,694,000	–	450,000	–	0.18%	–
IMUX	New	IMMUNIC INC	$8,582,000	–	700,000	–	0.17%	–
STOK	New	STOKE THERAPEUTICS INC	$8,415,000	–	250,000	–	0.17%	–
APLT	New	APPLIED THERAPEUTICS INC	$8,312,000	–	400,000	–	0.17%	–
SLDB	New	SOLID BIOSCIENCES INC	$8,235,000	–	2,250,000	–	0.17%	–
DSGN	New	DESIGN THERAPEUTICS INC	$7,956,000	–	400,000	–	0.16%	–
ORTX	New	ORCHARD THERAPEUTICS PLCads	$7,919,000	–	1,803,858	–	0.16%	–
ACIU	New	AC IMMUNE SA	$7,930,000	–	1,000,000	–	0.16%	–
SANA	New	SANA BIOTECHNOLOGY INC	$7,864,000	–	400,000	–	0.16%	–
IMCR	New	IMMUNOCORE HLDGS PLCads	$7,810,000	–	200,000	–	0.16%	–
ARAV	New	ARAVIVE INC	$7,842,000	–	1,311,291	–	0.16%	–
OMEG	New	OMEGA ALPHA SPACcl a	$7,463,000	–	750,000	–	0.15%	–
DCPH	New	DECIPHERA PHARMACEUTICALS IN	$7,322,000	–	200,000	–	0.15%	–
RXRX	New	RECURSION PHARMACEUTICALS INcl a	$7,300,000	–	200,000	–	0.15%	–
OLMA	New	OLEMA PHARMACEUTICALS INC	$7,289,000	–	260,500	–	0.15%	–
AGLE	New	AEGLEA BIOTHERAPEUTICS INC	$7,273,000	–	1,045,000	–	0.15%	–
ORIC	New	ORIC PHARMACEUTICALS INC	$7,076,000	–	400,000	–	0.14%	–
SPRO	New	SPERO THERAPEUTICS INC	$6,980,000	–	500,000	–	0.14%	–
CFRX	New	CONTRAFECT CORP	$6,600,000	–	1,500,000	–	0.13%	–
FUSN	New	FUSION PHARMACEUTICALS INC	$6,060,000	–	750,000	–	0.12%	–
HOOK	New	HOOKIPA PHARMA INC	$5,492,000	–	599,616	–	0.11%	–
ALPN	New	ALPINE IMMUNE SCIENCES INC	$5,337,000	–	593,030	–	0.11%	–
BHG	New	BRIGHT HEALTH GROUP INC	$5,243,000	–	305,555	–	0.11%	–
CRDF	New	CARDIFF ONCOLOGY INC	$4,988,000	–	750,000	–	0.10%	–
DYNS	New	DYNAMICS SPECIAL PURPOSE COR	$4,970,000	–	500,000	–	0.10%	–
LPTX	New	LEAP THERAPEUTICS INC	$4,920,000	–	3,000,000	–	0.10%	–
ALDX	New	ALDEYRA THERAPEUTICS INC	$4,893,000	–	431,894	–	0.10%	–
MCRB	New	SERES THERAPEUTICS INC	$4,770,000	–	200,000	–	0.10%	–
MREO	New	MEREO BIOPHARMA GROUP PLCads	$4,755,000	–	1,500,000	–	0.10%	–
IMMP	New	IMMUTEP LTDsponsored ads	$3,870,000	–	1,000,000	–	0.08%	–
KLDO	New	KALEIDO BIOSCIENCES INC	$3,724,000	–	500,500	–	0.08%	–
CDAK	New	CODIAK BIOSCIENCES INC	$3,706,000	–	200,000	–	0.08%	–
MTCR	New	METACRINE INC	$3,515,000	–	924,898	–	0.07%	–
RNA	New	AVIDITY BIOSCIENCES INC	$3,521,000	–	142,500	–	0.07%	–
VIAC	New	VIACOMCBS INCcl b	$3,390,000	–	75,000	–	0.07%	–
SGTX	New	SIGILON THERAPEUTICS INC	$2,961,000	–	276,000	–	0.06%	–
KNTE	New	KINNATE BIOPHARMA INC	$2,910,000	–	125,000	–	0.06%	–
MEIP	New	MEI PHARMA INC	$2,850,000	–	1,000,000	–	0.06%	–
AXLA	New	AXCELLA HEALTH INC	$2,857,000	–	712,500	–	0.06%	–
CGEM	New	CULLINAN ONCOLOGY INC	$2,575,000	–	100,000	–	0.05%	–
KDNY	New	CHINOOK THERAPEUTICS INC	$2,549,000	–	180,500	–	0.05%	–
YMTX	New	YUMANITY THERAPEUTICS INC	$2,533,000	–	217,391	–	0.05%	–
LVTX	New	LAVA THERAPEUTICS NV	$2,176,000	–	200,000	–	0.04%	–
MOLN	New	MOLECULAR PARTNERS AGads	$2,049,000	–	100,000	–	0.04%	–
CHMA	New	CHIASMA INC	$1,797,000	–	380,000	–	0.04%	–
IRWD	New	IRONWOOD PHARMACEUTICALS INC	$1,423,000	–	110,532	–	0.03%	–
RIGL	New	RIGEL PHARMACEUTICALS INC	$1,394,000	–	321,100	–	0.03%	–
CEREW	New	CEREVEL THERAPEUTICS HLDNG I*w exp 06/09/202	$1,145,000	–	79,600	–	0.02%	–
SURF	New	SURFACE ONCOLOGY INC	$746,000	–	100,000	–	0.02%	–
LU	New	LUFAX HOLDING LTD	$565,000	–	50,000	–	0.01%	–
CDTX	New	CIDARA THERAPEUTICS INC	$454,000	–	224,675	–	0.01%	–

Q4 2020

			Value		Shares		↓ Weighting
IDYA	Exit	IDEAYA BIOSCIENCES INC	$0	–	-8	–	0.00%	–
PASG	Exit	PASSAGE BIO INC	$0	–	-15,648	–	-0.01%	–
CDTX	Exit	CIDARA THERAPEUTICS INC	$0	–	-224,675	–	-0.02%	–
RIGL	Exit	RIGEL PHARMACEUTICALS INC	$0	–	-321,100	–	-0.02%	–
IRWD	Exit	IRONWOOD PHARMACEUTICALS INC	$0	–	-110,532	–	-0.02%	–
BLU	Exit	BELLUS HEALTH INC NEW	$0	–	-475,000	–	-0.03%	–
CTMX	Exit	CYTOMX THERAPEUTICS INC	$0	–	-178,600	–	-0.03%	–
ORTX	Exit	ORCHARD THERAPEUTICS PLCads	$0	–	-351,500	–	-0.04%	–
XLE	Exit	SELECT SECTOR SPDR TRcall	$0	–	-50,000	–	-0.04%	–
ACET	Exit	ADICET BIO INC	$0	–	-129,335	–	-0.04%	–
CHMA	Exit	CHIASMA INC	$0	–	-380,000	–	-0.04%	–
PAND	Exit	PANDION THERAPEUTICS INC	$0	–	-145,000	–	-0.04%	–
CRIS	Exit	CURIS INC	$0	–	-1,404,729	–	-0.04%	–
ADRO	Exit	ADURO BIOTECH INC	$0	–	-902,500	–	-0.05%	–
MEIP	Exit	MEI PHARMA INC	$0	–	-760,000	–	-0.06%	–
NERV	Exit	MINERVA NEUROSCIENCES INC	$0	–	-760,000	–	-0.06%	–
EVLO	Exit	EVELO BIOSCIENCES INC	$0	–	-475,000	–	-0.06%	–
PTGX	Exit	PROTAGONIST THERAPEUTICS INC	$0	–	-133,000	–	-0.06%	–
ZNTL	Exit	ZENTALIS PHARMACEUTICALS INC	$0	–	-87,400	–	-0.07%	–
MRUS	Exit	MERUS N V	$0	–	-250,000	–	-0.07%	–
PRVL	Exit	PREVAIL THERAPEUTICS INC	$0	–	-302,750	–	-0.08%	–
ADCT	Exit	ADC THERAPEUTICS SA	$0	–	-95,000	–	-0.08%	–
AXLA	Exit	AXCELLA HEALTH INC	$0	–	-712,500	–	-0.08%	–
AUTL	Exit	AUTOLUS THERAPEUTICS PLCsponsored ads	$0	–	-285,000	–	-0.08%	–
SLDB	Exit	SOLID BIOSCIENCES INC	$0	–	-1,710,000	–	-0.08%	–
PRTA	Exit	PROTHENA CORP PLC	$0	–	-351,500	–	-0.08%	–
ORIC	Exit	ORIC PHARMACEUTICALS INC	$0	–	-142,500	–	-0.09%	–
OXY	Exit	OCCIDENTAL PETE CORP	$0	–	-375,000	–	-0.09%	–
NTLA	Exit	INTELLIA THERAPEUTICS INC	$0	–	-190,000	–	-0.09%	–
ALXO	Exit	ALX ONCOLOGY HLDGS INC	$0	–	-100,000	–	-0.09%	–
RNA	Exit	AVIDITY BIOSCIENCES INC	$0	–	-142,500	–	-0.10%	–
YI	Exit	111 INCads	$0	–	-650,000	–	-0.10%	–
SYRS	Exit	SYROS PHARMACEUTICALS INC	$0	–	-465,500	–	-0.10%	–
AXDX	Exit	ACCELERATE DIAGNOSTICS INC	$0	–	-427,500	–	-0.11%	–
ACIU	Exit	AC IMMUNE SA	$0	–	-1,000,000	–	-0.12%	–
ADPT	Exit	ADAPTIVE BIOTECHNOLOGIES COR	$0	–	-100,000	–	-0.12%	–
VXRT	Exit	VAXART INC	$0	–	-750,000	–	-0.12%	–
APTX	Exit	APTINYX INC	$0	–	-1,502,035	–	-0.12%	–
ALPN	Exit	ALPINE IMMUNE SCIENCES INC	$0	–	-593,030	–	-0.13%	–
KLDO	Exit	KALEIDO BIOSCIENCES INC	$0	–	-500,500	–	-0.14%	–
LPTX	Exit	LEAP THERAPEUTICS INC	$0	–	-2,825,300	–	-0.14%	–
HOOK	Exit	HOOKIPA PHARMA INC	$0	–	-599,616	–	-0.14%	–
PRQR	Exit	PROQR THRAPEUTICS N V	$0	–	-1,196,218	–	-0.14%	–
RGNX	Exit	REGENXBIO INC	$0	–	-222,300	–	-0.15%	–
AAL	Exit	AMERICAN AIRLS GROUP INCcall	$0	–	-500,000	–	-0.15%	–
ARAV	Exit	ARAVIVE INC	$0	–	-1,311,291	–	-0.15%	–
SPRO	Exit	SPERO THERAPEUTICS INC	$0	–	-600,000	–	-0.16%	–
BRKR	Exit	BRUKER CORP	$0	–	-175,275	–	-0.17%	–
PMVP	Exit	PMV PHARMACEUTICALS INC	$0	–	-200,000	–	-0.17%	–
AGLE	Exit	AEGLEA BIOTHERAPEUTICS INC	$0	–	-1,045,000	–	-0.18%	–
DYN	Exit	DYNE THERAPEUTICS INC	$0	–	-370,000	–	-0.18%	–
APLT	Exit	APPLIED THERAPEUTICS INC	$0	–	-380,000	–	-0.19%	–
KYMR	Exit	KYMERA THERAPEUTICS INC	$0	–	-250,000	–	-0.20%	–
MCRB	Exit	SERES THERAPEUTICS INC	$0	–	-300,000	–	-0.21%	–
STOK	Exit	STOKE THERAPEUTICS INC	$0	–	-270,750	–	-0.22%	–
ESPR	Exit	ESPERION THERAPEUTICS INC NE	$0	–	-250,000	–	-0.23%	–
TCRR	Exit	TCR2 THERAPEUTICS INC	$0	–	-500,000	–	-0.25%	–
KRYS	Exit	KRYSTAL BIOTECH INC	$0	–	-237,500	–	-0.25%	–
RPRX	Exit	ROYALTY PHARMA PLC	$0	–	-250,000	–	-0.26%	–
YMAB	Exit	Y-MABS THERAPEUTICS INC	$0	–	-285,028	–	-0.27%	–
CYCN	Exit	CYCLERION THERAPEUTICS INC	$0	–	-1,817,584	–	-0.27%	–
SELB	Exit	SELECTA BIOSCIENCES INC	$0	–	-4,500,000	–	-0.27%	–
BMRN	Exit	BIOMARIN PHARMACEUTICAL INCcall	$0	–	-150,000	–	-0.28%	–
EPZM	Exit	EPIZYME INC	$0	–	-1,000,000	–	-0.29%	–
CRDF	Exit	CARDIFF ONCOLOGY INC	$0	–	-900,000	–	-0.31%	–
IOVA	Exit	IOVANCE BIOTHERAPEUTICS INC	$0	–	-400,000	–	-0.32%	–
MTCR	Exit	METACRINE INC	$0	–	-1,309,513	–	-0.32%	–
HARP	Exit	HARPOON THERAPEUTICS INC	$0	–	-800,000	–	-0.33%	–
SWTX	Exit	SPRINGWORKS THERAPEUTICS INC	$0	–	-285,000	–	-0.33%	–
SAGE	Exit	SAGE THERAPEUTICS INC	$0	–	-222,300	–	-0.33%	–
FOLD	Exit	AMICUS THERAPEUTICS INCcall	$0	–	-1,000,000	–	-0.34%	–
OVID	Exit	OVID THERAPEUTICS INC	$0	–	-2,500,000	–	-0.35%	–
DNLI	Exit	DENALI THERAPEUTICS INC	$0	–	-400,000	–	-0.35%	–
AUPH	Exit	AURINIA PHARMACEUTICALS INC	$0	–	-1,000,000	–	-0.36%	–
GM	Exit	GENERAL MTRS COcall	$0	–	-500,000	–	-0.36%	–
TECH	Exit	BIO-TECHNE CORP	$0	–	-60,000	–	-0.36%	–
IMUX	Exit	IMMUNIC INC	$0	–	-800,000	–	-0.36%	–
BBIO	Exit	BRIDGEBIO PHARMA INC	$0	–	-400,000	–	-0.36%	–
FGEN	Exit	FIBROGEN INC	$0	–	-380,000	–	-0.38%	–
REPL	Exit	REPLIMUNE GROUP INC	$0	–	-700,000	–	-0.39%	–
DHR	Exit	DANAHER CORPORATION	$0	–	-75,000	–	-0.39%	–
KURA	Exit	KURA ONCOLOGY INC	$0	–	-549,100	–	-0.41%	–
RLAY	Exit	RELAY THERAPEUTICS INC	$0	–	-400,000	–	-0.41%	–
RPTX	Exit	REPARE THERAPEUTICS INC	$0	–	-570,000	–	-0.43%	–
TCOM	Exit	TRIP COM GROUP LTDads	$0	–	-570,000	–	-0.43%	–
ADVM	Exit	ADVERUM BIOTECHNOLOGIES INC	$0	–	-1,800,000	–	-0.45%	–
MRSN	Exit	MERSANA THERAPEUTICS INC	$0	–	-1,000,000	–	-0.45%	–
RUBY	Exit	RUBIUS THERAPEUTICS INC	$0	–	-3,778,913	–	-0.46%	–
TBIO	Exit	TRANSLATE BIO INC	$0	–	-1,400,000	–	-0.46%	–
Z	Exit	ZILLOW GROUP INCcl c cap stk	$0	–	-200,000	–	-0.49%	–
STNE	Exit	STONECO LTD	$0	–	-400,000	–	-0.51%	–
MRNA	Exit	MODERNA INC	$0	–	-300,000	–	-0.52%	–
	Exit	TRILLIUM THERAPEUTICS INC	$0	–	-1,500,000	–	-0.52%	–
C	Exit	CITIGROUP INCcall	$0	–	-500,000	–	-0.52%	–
AAPL	Exit	APPLE INCcall	$0	–	-200,000	–	-0.56%	–
MS	Exit	MORGAN STANLEYcall	$0	–	-500,000	–	-0.59%	–
TSHA	Exit	TAYSHA GENE THERAPIES INC	$0	–	-1,140,882	–	-0.62%	–
ITOS	Exit	ITEOS THERAPEUTICS INC	$0	–	-1,094,047	–	-0.66%	–
AGEN	Exit	AGENUS INC	$0	–	-6,900,000	–	-0.67%	–
QURE	Exit	UNIQURE NV	$0	–	-750,000	–	-0.67%	–
TPTX	Exit	TURNING POINT THERAPEUTICS I	$0	–	-325,000	–	-0.69%	–
ALBO	Exit	ALBIREO PHARMA INC	$0	–	-851,405	–	-0.69%	–
ATRA	Exit	ATARA BIOTHERAPEUTICS INC	$0	–	-2,250,000	–	-0.71%	–
GOSS	Exit	GOSSAMER BIO INC	$0	–	-2,358,968	–	-0.71%	–
DCPH	Exit	DECIPHERA PHARMACEUTICALS IN	$0	–	-600,000	–	-0.75%	–
NG	Exit	NOVAGOLD RES INC	$0	–	-2,600,000	–	-0.75%	–
IMAB	Exit	I MABsponsored ads	$0	–	-725,000	–	-0.83%	–
XLI	Exit	SELECT SECTOR SPDR TRcall	$0	–	-500,000	–	-0.93%	–
TGTX	Exit	TG THERAPEUTICS INC	$0	–	-1,500,000	–	-0.97%	–
FOLD	Exit	AMICUS THERAPEUTICS INC	$0	–	-3,000,000	–	-1.03%	–
SDGR	Exit	SCHRODINGER INC	$0	–	-897,445	–	-1.04%	–
ABBV	Exit	ABBVIE INCcall	$0	–	-500,000	–	-1.06%	–
SRRK	Exit	SCHOLAR ROCK HLDG CORP	$0	–	-2,495,140	–	-1.07%	–
MORF	Exit	MORPHIC HLDG INC	$0	–	-1,651,686	–	-1.10%	–
BDTX	Exit	BLACK DIAMOND THERAPEUTICS I	$0	–	-1,521,517	–	-1.12%	–
BAC	Exit	BK OF AMERICA CORPcall	$0	–	-2,000,000	–	-1.17%	–
IGMS	Exit	IGM BIOSCIENCES INC	$0	–	-688,910	–	-1.23%	–
BEKE	Exit	KE HLDGS INCsponsored ads	$0	–	-870,000	–	-1.30%	–
FATE	Exit	FATE THERAPEUTICS INC	$0	–	-1,500,000	–	-1.46%	–
ALVR	Exit	ALLOVIR INC	$0	–	-2,323,371	–	-1.55%	–
GDS	Exit	GDS HLDGS LTDsponsored ads	$0	–	-1,000,000	–	-1.99%	–
MRTX	Exit	MIRATI THERAPEUTICS INC	$0	–	-500,000	–	-2.02%	–
ARGX	Exit	ARGENX SEsponsored adr	$0	–	-324,200	–	-2.07%	–
LXRX	Exit	LEXICON PHARMACEUTICALS INC	$0	–	-60,240,864	–	-2.11%	–
GBIO	Exit	GENERATION BIO CO	$0	–	-2,814,191	–	-2.11%	–
JPM	Exit	JPMORGAN CHASE & COcall	$0	–	-1,000,000	–	-2.34%	–
ALNY	Exit	ALNYLAM PHARMACEUTICALS INC	$0	–	-800,000	–	-2.83%	–
BNTX	Exit	BIONTECH SEsponsored ads	$0	–	-1,731,214	–	-2.91%	–
BABA	Exit	ALIBABA GROUP HLDG LTDsponsored ads	$0	–	-425,000	–	-3.03%	–
XLRN	Exit	ACCELERON PHARMA INC	$0	–	-1,400,000	–	-3.82%	–
GS	Exit	GOLDMAN SACHS GROUP INCcall	$0	–	-875,000	–	-4.27%	–
BGNE	Exit	BEIGENE LTDsponsored adr	$0	–	-900,000	–	-6.26%	–
WW	Exit	WW INTL INC	$0	–	-14,818,300	–	-6.79%	–
QQQ	Exit	INVESCO QQQ TRput	$0	–	-2,058,000	–	-13.88%	–

Q3 2020

			Value		Shares		↓ Weighting
QQQ	New	INVESCO QQQ TRput	$571,795,000	–	2,058,000	–	13.88%	–
BGNE	Buy	BEIGENE LTDsponsored adr	$257,796,000	+61.0%	900,000	+5.9%	6.26%	+39.7%
GS	Buy	GOLDMAN SACHS GROUP INCcall	$175,849,000	+344.9%	875,000	+337.5%	4.27%	+286.0%
BABA	Buy	ALIBABA GROUP HLDG LTDsponsored ads	$124,942,000	+55.5%	425,000	+14.1%	3.03%	+34.9%
BNTX	Sell	BIONTECH SEsponsored ads	$119,852,000	-10.2%	1,731,214	-13.4%	2.91%	-22.1%
ALNY	Sell	ALNYLAM PHARMACEUTICALS INC	$116,480,000	-12.6%	800,000	-11.1%	2.83%	-24.2%
JPM	Sell	JPMORGAN CHASE & COcall	$96,270,000	-65.9%	1,000,000	-66.7%	2.34%	-70.4%
ARGX	Sell	ARGENX SEsponsored adr	$85,109,000	-16.0%	324,200	-28.0%	2.07%	-27.2%
MRTX	New	MIRATI THERAPEUTICS INC	$83,025,000	–	500,000	–	2.02%	–
GDS	Sell	GDS HLDGS LTDsponsored ads	$81,830,000	-6.6%	1,000,000	-9.1%	1.99%	-19.0%
ALVR	New	ALLOVIR INC	$63,893,000	–	2,323,371	–	1.55%	–
FATE	Sell	FATE THERAPEUTICS INC	$59,955,000	-2.9%	1,500,000	-16.7%	1.46%	-15.8%
BEKE	New	KE HLDGS INCsponsored ads	$53,331,000	–	870,000	–	1.30%	–
IGMS	New	IGM BIOSCIENCES INC	$50,848,000	–	688,910	–	1.23%	–
BAC	Buy	BK OF AMERICA CORPcall	$48,180,000	+102.9%	2,000,000	+100.0%	1.17%	+75.9%
BDTX	Sell	BLACK DIAMOND THERAPEUTICS I	$45,995,000	-29.5%	1,521,517	-1.6%	1.12%	-38.8%
MORF	Sell	MORPHIC HLDG INC	$45,157,000	+0.0%	1,651,686	-1.0%	1.10%	-13.2%
SRRK	Sell	SCHOLAR ROCK HLDG CORP	$44,139,000	-4.0%	2,495,140	-1.1%	1.07%	-16.6%
ABBV	Buy	ABBVIE INCcall	$43,795,000	+78.4%	500,000	+100.0%	1.06%	+54.7%
FOLD	Sell	AMICUS THERAPEUTICS INC	$42,360,000	-19.7%	3,000,000	-14.3%	1.03%	-30.4%
TGTX	Sell	TG THERAPEUTICS INC	$40,140,000	+17.7%	1,500,000	-14.3%	0.97%	+2.1%
XLI	Buy	SELECT SECTOR SPDR TRcall	$38,490,000	+24.5%	500,000	+11.1%	0.93%	+8.0%
IMAB	Buy	I MABsponsored ads	$34,097,000	+251.6%	725,000	+123.8%	0.83%	+205.5%
DCPH	Sell	DECIPHERA PHARMACEUTICALS IN	$30,780,000	-20.7%	600,000	-7.7%	0.75%	-31.2%
GOSS	Sell	GOSSAMER BIO INC	$29,275,000	-15.3%	2,358,968	-11.3%	0.71%	-26.5%
ATRA	Sell	ATARA BIOTHERAPEUTICS INC	$29,160,000	-19.9%	2,250,000	-10.0%	0.71%	-30.5%
ALBO	Buy	ALBIREO PHARMA INC	$28,411,000	+114.3%	851,405	+70.2%	0.69%	+86.0%
TPTX	Sell	TURNING POINT THERAPEUTICS I	$28,392,000	+25.6%	325,000	-7.1%	0.69%	+8.8%
QURE	Sell	UNIQURE NV	$27,623,000	-38.7%	750,000	-25.0%	0.67%	-46.8%
AGEN	Buy	AGENUS INC	$27,600,000	+146.4%	6,900,000	+142.1%	0.67%	+114.1%
ITOS	New	ITEOS THERAPEUTICS INC	$26,990,000	–	1,094,047	–	0.66%	–
TSHA	New	TAYSHA GENE THERAPIES INC	$25,556,000	–	1,140,882	–	0.62%	–
MS	New	MORGAN STANLEYcall	$24,175,000	–	500,000	–	0.59%	–
AAPL	New	APPLE INCcall	$23,162,000	–	200,000	–	0.56%	–
C	Sell	CITIGROUP INCcall	$21,555,000	-57.8%	500,000	-50.0%	0.52%	-63.4%
	Buy	TRILLIUM THERAPEUTICS INC	$21,315,000	+176.5%	1,500,000	+57.4%	0.52%	+139.4%
MRNA	Sell	MODERNA INC	$21,225,000	-33.9%	300,000	-40.0%	0.52%	-42.7%
STNE	Buy	STONECO LTD	$21,156,000	+88.2%	400,000	+37.9%	0.51%	+63.7%
Z	Sell	ZILLOW GROUP INCcl c cap stk	$20,318,000	-27.0%	200,000	-58.6%	0.49%	-36.7%
TBIO	Sell	TRANSLATE BIO INC	$19,054,000	-33.5%	1,400,000	-12.5%	0.46%	-42.3%
RUBY	Sell	RUBIUS THERAPEUTICS INC	$18,932,000	-17.8%	3,778,913	-1.9%	0.46%	-28.7%
MRSN	Buy	MERSANA THERAPEUTICS INC	$18,620,000	-0.5%	1,000,000	+25.0%	0.45%	-13.7%
ADVM	Buy	ADVERUM BIOTECHNOLOGIES INC	$18,540,000	-1.3%	1,800,000	+100.0%	0.45%	-14.4%
TCOM	Sell	TRIP COM GROUP LTDads	$17,750,000	+14.1%	570,000	-5.0%	0.43%	-0.9%
RPTX	Sell	REPARE THERAPEUTICS INC	$17,539,000	-5.8%	570,000	-5.0%	0.43%	-18.2%
RLAY	New	RELAY THERAPEUTICS INC	$17,036,000	–	400,000	–	0.41%	–
KURA	Sell	KURA ONCOLOGY INC	$16,824,000	+78.6%	549,100	-5.0%	0.41%	+54.5%
DHR	New	DANAHER CORPORATION	$16,150,000	–	75,000	–	0.39%	–
REPL	Sell	REPLIMUNE GROUP INC	$16,114,000	-13.5%	700,000	-6.7%	0.39%	-25.0%
FGEN	Sell	FIBROGEN INC	$15,626,000	-3.6%	380,000	-5.0%	0.38%	-16.5%
BBIO	Sell	BRIDGEBIO PHARMA INC	$15,008,000	-23.3%	400,000	-33.3%	0.36%	-33.5%
IMUX	Buy	IMMUNIC INC	$14,856,000	+104.3%	800,000	+33.3%	0.36%	+77.8%
TECH	Sell	BIO-TECHNE CORP	$14,864,000	-13.4%	60,000	-7.7%	0.36%	-24.8%
AUPH	Buy	AURINIA PHARMACEUTICALS INC	$14,730,000	+0.7%	1,000,000	+11.1%	0.36%	-12.5%
DNLI	Sell	DENALI THERAPEUTICS INC	$14,332,000	+31.7%	400,000	-11.1%	0.35%	+14.5%
OVID	New	OVID THERAPEUTICS INC	$14,350,000	–	2,500,000	–	0.35%	–
SAGE	Sell	SAGE THERAPEUTICS INC	$13,587,000	+39.6%	222,300	-5.0%	0.33%	+21.3%
SWTX	Sell	SPRINGWORKS THERAPEUTICS INC	$13,586,000	+7.8%	285,000	-5.0%	0.33%	-6.5%
HARP	Sell	HARPOON THERAPEUTICS INC	$13,592,000	-9.0%	800,000	-11.1%	0.33%	-21.1%
MTCR	New	METACRINE INC	$13,370,000	–	1,309,513	–	0.32%	–
IOVA	Sell	IOVANCE BIOTHERAPEUTICS INC	$13,168,000	-4.1%	400,000	-20.0%	0.32%	-16.7%
CRDF	New	CARDIFF ONCOLOGY INC	$12,771,000	–	900,000	–	0.31%	–
EPZM	Sell	EPIZYME INC	$11,930,000	-60.4%	1,000,000	-46.7%	0.29%	-65.6%
BMRN	New	BIOMARIN PHARMACEUTICAL INCcall	$11,412,000	–	150,000	–	0.28%	–
SELB	Buy	SELECTA BIOSCIENCES INC	$11,160,000	+35.5%	4,500,000	+55.2%	0.27%	+17.8%
CYCN	Sell	CYCLERION THERAPEUTICS INC	$11,051,000	+1.5%	1,817,584	-1.3%	0.27%	-11.8%
YMAB	Sell	Y-MABS THERAPEUTICS INC	$10,942,000	-15.6%	285,028	-5.0%	0.27%	-26.7%
RPRX	Sell	ROYALTY PHARMA PLC	$10,518,000	-71.1%	250,000	-66.7%	0.26%	-75.0%
KRYS	Buy	KRYSTAL BIOTECH INC	$10,224,000	+23.4%	237,500	+18.8%	0.25%	+6.9%
TCRR	Buy	TCR2 THERAPEUTICS INC	$10,160,000	+89.0%	500,000	+42.9%	0.25%	+64.7%
ESPR	New	ESPERION THERAPEUTICS INC NE	$9,293,000	–	250,000	–	0.23%	–
STOK	Sell	STOKE THERAPEUTICS INC	$9,067,000	+33.5%	270,750	-5.0%	0.22%	+15.8%
MCRB	New	SERES THERAPEUTICS INC	$8,493,000	–	300,000	–	0.21%	–
KYMR	New	KYMERA THERAPEUTICS INC	$8,078,000	–	250,000	–	0.20%	–
APLT	New	APPLIED THERAPEUTICS INC	$7,889,000	–	380,000	–	0.19%	–
DYN	New	DYNE THERAPEUTICS INC	$7,470,000	–	370,000	–	0.18%	–
AGLE	Sell	AEGLEA BIOTHERAPEUTICS INC	$7,409,000	-27.2%	1,045,000	-5.0%	0.18%	-36.8%
PMVP	New	PMV PHARMACEUTICALS INC	$7,100,000	–	200,000	–	0.17%	–
BRKR	Sell	BRUKER CORP	$6,967,000	-7.2%	175,275	-5.0%	0.17%	-19.5%
SPRO	Buy	SPERO THERAPEUTICS INC	$6,696,000	-9.2%	600,000	+10.1%	0.16%	-20.9%
ARAV	Sell	ARAVIVE INC	$6,163,000	-61.6%	1,311,291	-5.0%	0.15%	-66.7%
RGNX	Sell	REGENXBIO INC	$6,118,000	-29.0%	222,300	-5.0%	0.15%	-38.2%
PRQR	Sell	PROQR THRAPEUTICS N V	$5,730,000	-25.2%	1,196,218	-5.0%	0.14%	-35.0%
LPTX	Sell	LEAP THERAPEUTICS INC	$5,594,000	-10.0%	2,825,300	-5.0%	0.14%	-21.8%
ALPN	New	ALPINE IMMUNE SCIENCES INC	$5,213,000	–	593,030	–	0.13%	–
APTX	Sell	APTINYX INC	$5,077,000	-23.0%	1,502,035	-5.0%	0.12%	-33.2%
VXRT	Buy	VAXART INC	$4,988,000	+181.8%	750,000	+275.0%	0.12%	+142.0%
ADPT	Sell	ADAPTIVE BIOTECHNOLOGIES COR	$4,863,000	-46.5%	100,000	-46.8%	0.12%	-53.5%
ACIU	Buy	AC IMMUNE SA	$4,880,000	-26.4%	1,000,000	+1.6%	0.12%	-36.2%
AXDX	Sell	ACCELERATE DIAGNOSTICS INC	$4,557,000	-48.7%	427,500	-27.1%	0.11%	-55.4%
SYRS	Sell	SYROS PHARMACEUTICALS INC	$4,115,000	-21.2%	465,500	-5.0%	0.10%	-31.5%
RNA	Sell	AVIDITY BIOSCIENCES INC	$4,011,000	-18.9%	142,500	-18.6%	0.10%	-29.7%
ALXO	New	ALX ONCOLOGY HLDGS INC	$3,774,000	–	100,000	–	0.09%	–
NTLA	Sell	INTELLIA THERAPEUTICS INC	$3,777,000	-24.8%	190,000	-20.5%	0.09%	-34.8%
OXY	New	OCCIDENTAL PETE CORP	$3,754,000	–	375,000	–	0.09%	–
ORIC	Sell	ORIC PHARMACEUTICALS INC	$3,564,000	-29.6%	142,500	-5.0%	0.09%	-38.7%
PRTA	Sell	PROTHENA CORP PLC	$3,511,000	-9.3%	351,500	-5.0%	0.08%	-21.3%
SLDB	Sell	SOLID BIOSCIENCES INC	$3,471,000	-34.2%	1,710,000	-5.0%	0.08%	-43.2%
AUTL	Sell	AUTOLUS THERAPEUTICS PLCsponsored ads	$3,317,000	-48.3%	285,000	-28.8%	0.08%	-54.7%
AXLA	Sell	AXCELLA HEALTH INC	$3,292,000	-33.9%	712,500	-20.8%	0.08%	-42.4%
ADCT	Sell	ADC THERAPEUTICS SA	$3,134,000	-50.8%	95,000	-30.1%	0.08%	-57.3%
PRVL	Sell	PREVAIL THERAPEUTICS INC	$3,082,000	-44.1%	302,750	-18.2%	0.08%	-51.3%
MRUS	Sell	MERUS N V	$3,000,000	-51.4%	250,000	-34.9%	0.07%	-57.8%
ZNTL	Sell	ZENTALIS PHARMACEUTICALS INC	$2,857,000	-35.3%	87,400	-5.0%	0.07%	-44.4%
PTGX	Sell	PROTAGONIST THERAPEUTICS INC	$2,600,000	+5.2%	133,000	-5.0%	0.06%	-8.7%
EVLO	Sell	EVELO BIOSCIENCES INC	$2,503,000	-23.4%	475,000	-28.7%	0.06%	-33.0%
NERV	Sell	MINERVA NEUROSCIENCES INC	$2,417,000	-16.3%	760,000	-5.0%	0.06%	-27.2%
MEIP	Buy	MEI PHARMA INC	$2,371,000	-19.6%	760,000	+6.4%	0.06%	-30.1%
ADRO	Sell	ADURO BIOTECH INC	$2,193,000	-0.1%	902,500	-5.0%	0.05%	-13.1%
PAND	New	PANDION THERAPEUTICS INC	$1,662,000	–	145,000	–	0.04%	–
CRIS	Sell	CURIS INC	$1,644,000	-8.1%	1,404,729	-5.0%	0.04%	-20.0%
CHMA	New	CHIASMA INC	$1,634,000	–	380,000	–	0.04%	–
ACET	New	ADICET BIO INC	$1,538,000	–	129,335	–	0.04%	–
ORTX	Sell	ORCHARD THERAPEUTICS PLCads	$1,445,000	-34.9%	351,500	-5.0%	0.04%	-43.5%
CTMX	Sell	CYTOMX THERAPEUTICS INC	$1,188,000	-24.1%	178,600	-5.0%	0.03%	-34.1%
BLU	Buy	BELLUS HEALTH INC NEW	$1,078,000	-27.1%	475,000	+230.4%	0.03%	-36.6%
RIGL	Sell	RIGEL PHARMACEUTICALS INC	$771,000	+24.6%	321,100	-5.0%	0.02%	+11.8%
CDTX	Sell	CIDARA THERAPEUTICS INC	$640,000	-26.7%	224,675	-5.0%	0.02%	-33.3%
PASG	Sell	PASSAGE BIO INC	$205,000	-96.8%	15,648	-93.3%	0.01%	-97.2%
IDYA	Sell	IDEAYA BIOSCIENCES INC	$0	-100.0%	8	-100.0%	0.00%	-100.0%
TORC	Exit	RESTORBIO INC	$0	–	-953,000	–	-0.06%	–
CYRX	Exit	CRYOPORT INC	$0	–	-89,000	–	-0.08%	–
CLVS	Exit	CLOVIS ONCOLOGY INCcall	$0	–	-500,000	–	-0.09%	–
MGTA	Exit	MAGENTA THERAPEUTICS INC	$0	–	-450,000	–	-0.10%	–
ALEC	Exit	ALECTOR INC	$0	–	-200,000	–	-0.14%	–
NKTR	Exit	NEKTAR THERAPEUTICS	$0	–	-239,000	–	-0.16%	–
TSM	Exit	TAIWAN SEMICONDUCTOR MFG LTDcall	$0	–	-100,000	–	-0.16%	–
HTHT	Exit	HUAZHU GROUP LTDsponsored ads	$0	–	-175,000	–	-0.17%	–
MLCO	Exit	MELCO RESORTS AND ENTMNT LTDcall	$0	–	-500,000	–	-0.22%	–
AKBA	Exit	AKEBIA THERAPEUTICS INC	$0	–	-574,000	–	-0.22%	–
TCDA	Exit	TRICIDA INC	$0	–	-285,000	–	-0.22%	–
IMMU	Exit	IMMUNOMEDICS INC	$0	–	-230,838	–	-0.23%	–
ASND	Exit	ASCENDIS PHARMA A Ssponsored adr	$0	–	-65,000	–	-0.27%	–
BNTX	Exit	BIONTECH SEcall	$0	–	-150,000	–	-0.28%	–
PRNB	Exit	PRINCIPIA BIOPHARMA INC	$0	–	-200,000	–	-0.34%	–
VNET	Exit	21VIANET GROUP INCsponsored ads	$0	–	-583,000	–	-0.39%	–
ALNY	Exit	ALNYLAM PHARMACEUTICALS INCcall	$0	–	-100,000	–	-0.41%	–
EPZM	Exit	EPIZYME INCcall	$0	–	-1,000,000	–	-0.45%	–
AAL	Exit	AMERICAN AIRLS GROUP INC	$0	–	-1,500,000	–	-0.55%	–
AGIO	Exit	AGIOS PHARMACEUTICALS INC	$0	–	-376,000	–	-0.56%	–
AVTR	Exit	AVANTOR INC	$0	–	-2,000,000	–	-0.95%	–
PYPL	Exit	PAYPAL HLDGS INC	$0	–	-200,000	–	-0.98%	–
DAL	Exit	DELTA AIR LINES INC DELcall	$0	–	-1,250,000	–	-0.98%	–
BPMC	Exit	BLUEPRINT MEDICINES CORP	$0	–	-550,000	–	-1.20%	–
ALXN	Exit	ALEXION PHARMACEUTICALS INCcall	$0	–	-500,000	–	-1.57%	–

Q2 2020

			Value		Shares		↓ Weighting
WW	New	WW INTL INC	$376,088,000	–	14,818,300	–	10.52%	–
JPM	New	JPMORGAN CHASE & COcall	$282,180,000	–	3,000,000	–	7.90%	–
BGNE	New	BEIGENE LTDsponsored adr	$160,140,000	–	850,000	–	4.48%	–
BNTX	New	BIONTECH SEsponsored ads	$133,480,000	–	2,000,000	–	3.74%	–
XLRN	New	ACCELERON PHARMA INC	$133,378,000	–	1,400,000	–	3.73%	–
ALNY	New	ALNYLAM PHARMACEUTICALS INC	$133,299,000	–	900,000	–	3.73%	–
LXRX	New	LEXICON PHARMACEUTICALS INC	$120,181,000	–	60,240,864	–	3.36%	–
ARGX	New	ARGENX SEsponsored adr	$101,354,000	–	450,000	–	2.84%	–
GDS	New	GDS HLDGS LTDsponsored ads	$87,626,000	–	1,100,000	–	2.45%	–
SDGR	New	SCHRODINGER INC	$82,179,000	–	897,445	–	2.30%	–
BABA	New	ALIBABA GROUP HLDG LTDsponsored ads	$80,348,000	–	372,500	–	2.25%	–
BDTX	New	BLACK DIAMOND THERAPEUTICS I	$65,201,000	–	1,546,517	–	1.82%	–
FATE	New	FATE THERAPEUTICS INC	$61,758,000	–	1,800,000	–	1.73%	–
GBIO	New	GENERATION BIO CO	$59,098,000	–	2,814,191	–	1.65%	–
ALXN	New	ALEXION PHARMACEUTICALS INCcall	$56,120,000	–	500,000	–	1.57%	–
FOLD	New	AMICUS THERAPEUTICS INC	$52,780,000	–	3,500,000	–	1.48%	–
C	New	CITIGROUP INCcall	$51,100,000	–	1,000,000	–	1.43%	–
SRRK	New	SCHOLAR ROCK HLDG CORP	$45,963,000	–	2,524,040	–	1.29%	–
MORF	New	MORPHIC HLDG INC	$45,151,000	–	1,669,186	–	1.26%	–
QURE	New	UNIQURE NV	$45,060,000	–	1,000,000	–	1.26%	–
BPMC	New	BLUEPRINT MEDICINES CORP	$42,900,000	–	550,000	–	1.20%	–
GS	New	GOLDMAN SACHS GROUP INCcall	$39,524,000	–	200,000	–	1.11%	–
DCPH	New	DECIPHERA PHARMACEUTICALS IN	$38,818,000	–	650,000	–	1.09%	–
RPRX	New	ROYALTY PHARMA PLC	$36,413,000	–	750,000	–	1.02%	–
ATRA	New	ATARA BIOTHERAPEUTICS INC	$36,425,000	–	2,500,000	–	1.02%	–
DAL	New	DELTA AIR LINES INC DELcall	$35,063,000	–	1,250,000	–	0.98%	–
PYPL	New	PAYPAL HLDGS INC	$34,846,000	–	200,000	–	0.98%	–
GOSS	New	GOSSAMER BIO INC	$34,567,000	–	2,658,968	–	0.97%	–
TGTX	New	TG THERAPEUTICS INC	$34,090,000	–	1,750,000	–	0.95%	–
AVTR	New	AVANTOR INC	$34,000,000	–	2,000,000	–	0.95%	–
MRNA	New	MODERNA INC	$32,105,000	–	500,000	–	0.90%	–
XLI	New	SELECT SECTOR SPDR TRcall	$30,915,000	–	450,000	–	0.86%	–
EPZM	New	EPIZYME INC	$30,113,000	–	1,875,000	–	0.84%	–
TBIO	New	TRANSLATE BIO INC	$28,672,000	–	1,600,000	–	0.80%	–
Z	New	ZILLOW GROUP INCcl c cap stk	$27,826,000	–	483,000	–	0.78%	–
ABBV	New	ABBVIE INCcall	$24,545,000	–	250,000	–	0.69%	–
NG	New	NOVAGOLD RES INC	$23,868,000	–	2,600,000	–	0.67%	–
BAC	New	BK OF AMERICA CORPcall	$23,750,000	–	1,000,000	–	0.66%	–
RUBY	New	RUBIUS THERAPEUTICS INC	$23,037,000	–	3,852,341	–	0.64%	–
TPTX	New	TURNING POINT THERAPEUTICS I	$22,607,000	–	350,000	–	0.63%	–
AGIO	New	AGIOS PHARMACEUTICALS INC	$20,108,000	–	376,000	–	0.56%	–
AAL	New	AMERICAN AIRLS GROUP INC	$19,605,000	–	1,500,000	–	0.55%	–
BBIO	New	BRIDGEBIO PHARMA INC	$19,566,000	–	600,000	–	0.55%	–
ADVM	New	ADVERUM BIOTECHNOLOGIES INC	$18,792,000	–	900,000	–	0.53%	–
MRSN	New	MERSANA THERAPEUTICS INC	$18,720,000	–	800,000	–	0.52%	–
REPL	New	REPLIMUNE GROUP INC	$18,638,000	–	750,000	–	0.52%	–
RPTX	New	REPARE THERAPEUTICS INC	$18,612,000	–	600,000	–	0.52%	–
TECH	New	BIO-TECHNE CORP	$17,165,000	–	65,000	–	0.48%	–
FGEN	New	FIBROGEN INC	$16,212,000	–	400,000	–	0.45%	–
ARAV	New	ARAVIVE INC	$16,067,000	–	1,380,306	–	0.45%	–
EPZM	New	EPIZYME INCcall	$16,060,000	–	1,000,000	–	0.45%	–
TCOM	New	TRIP COM GROUP LTDads	$15,552,000	–	600,000	–	0.44%	–
FOLD	New	AMICUS THERAPEUTICS INCcall	$15,080,000	–	1,000,000	–	0.42%	–
HARP	New	HARPOON THERAPEUTICS INC	$14,940,000	–	900,000	–	0.42%	–
ALNY	New	ALNYLAM PHARMACEUTICALS INCcall	$14,811,000	–	100,000	–	0.41%	–
AUPH	New	AURINIA PHARMACEUTICALS INC	$14,625,000	–	900,000	–	0.41%	–
VNET	New	21VIANET GROUP INCsponsored ads	$13,910,000	–	583,000	–	0.39%	–
IOVA	New	IOVANCE BIOTHERAPEUTICS INC	$13,725,000	–	500,000	–	0.38%	–
ALBO	New	ALBIREO PHARMA INC	$13,255,000	–	500,360	–	0.37%	–
YMAB	New	Y-MABS THERAPEUTICS INC	$12,961,000	–	300,030	–	0.36%	–
GM	New	GENERAL MTRS COcall	$12,650,000	–	500,000	–	0.35%	–
SWTX	New	SPRINGWORKS THERAPEUTICS INC	$12,600,000	–	300,000	–	0.35%	–
PRNB	New	PRINCIPIA BIOPHARMA INC	$11,958,000	–	200,000	–	0.34%	–
STNE	New	STONECO LTD	$11,240,000	–	290,000	–	0.31%	–
AGEN	New	AGENUS INC	$11,201,000	–	2,850,000	–	0.31%	–
DNLI	New	DENALI THERAPEUTICS INC	$10,881,000	–	450,000	–	0.30%	–
CYCN	New	CYCLERION THERAPEUTICS INC	$10,883,000	–	1,841,584	–	0.30%	–
AGLE	New	AEGLEA BIOTHERAPEUTICS INC	$10,175,000	–	1,100,000	–	0.28%	–
BNTX	New	BIONTECH SEcall	$10,011,000	–	150,000	–	0.28%	–
SAGE	New	SAGE THERAPEUTICS INC	$9,730,000	–	234,000	–	0.27%	–
IMAB	New	I MABsponsored ads	$9,697,000	–	324,000	–	0.27%	–
ASND	New	ASCENDIS PHARMA A Ssponsored adr	$9,614,000	–	65,000	–	0.27%	–
KURA	New	KURA ONCOLOGY INC	$9,421,000	–	578,000	–	0.26%	–
ADPT	New	ADAPTIVE BIOTECHNOLOGIES COR	$9,095,000	–	188,000	–	0.25%	–
AXDX	New	ACCELERATE DIAGNOSTICS INC	$8,891,000	–	586,500	–	0.25%	–
RGNX	New	REGENXBIO INC	$8,618,000	–	234,000	–	0.24%	–
KRYS	New	KRYSTAL BIOTECH INC	$8,284,000	–	200,000	–	0.23%	–
SELB	New	SELECTA BIOSCIENCES INC	$8,236,000	–	2,900,000	–	0.23%	–
IMMU	New	IMMUNOMEDICS INC	$8,181,000	–	230,838	–	0.23%	–
TCDA	New	TRICIDA INC	$7,832,000	–	285,000	–	0.22%	–
AKBA	New	AKEBIA THERAPEUTICS INC	$7,795,000	–	574,000	–	0.22%	–
MLCO	New	MELCO RESORTS AND ENTMNT LTDcall	$7,760,000	–	500,000	–	0.22%	–
	New	TRILLIUM THERAPEUTICS INC	$7,710,000	–	953,000	–	0.22%	–
PRQR	New	PROQR THRAPEUTICS N V	$7,656,000	–	1,259,177	–	0.21%	–
BRKR	New	BRUKER CORP	$7,505,000	–	184,500	–	0.21%	–
SPRO	New	SPERO THERAPEUTICS INC	$7,374,000	–	545,040	–	0.21%	–
IMUX	New	IMMUNIC INC	$7,272,000	–	600,000	–	0.20%	–
HOOK	New	HOOKIPA PHARMA INC	$6,968,000	–	599,616	–	0.20%	–
STOK	New	STOKE THERAPEUTICS INC	$6,792,000	–	285,000	–	0.19%	–
ACIU	New	AC IMMUNE SA	$6,626,000	–	984,550	–	0.18%	–
APTX	New	APTINYX INC	$6,593,000	–	1,581,090	–	0.18%	–
AAL	New	AMERICAN AIRLS GROUP INCcall	$6,535,000	–	500,000	–	0.18%	–
PASG	New	PASSAGE BIO INC	$6,395,000	–	234,000	–	0.18%	–
AUTL	New	AUTOLUS THERAPEUTICS PLCsponsored ads	$6,412,000	–	400,000	–	0.18%	–
ADCT	New	ADC THERAPEUTICS SA	$6,366,000	–	136,000	–	0.18%	–
LPTX	New	LEAP THERAPEUTICS INC	$6,216,000	–	2,974,000	–	0.17%	–
MRUS	New	MERUS N V	$6,179,000	–	384,000	–	0.17%	–
HTHT	New	HUAZHU GROUP LTDsponsored ads	$6,134,000	–	175,000	–	0.17%	–
TSM	New	TAIWAN SEMICONDUCTOR MFG LTDcall	$5,677,000	–	100,000	–	0.16%	–
NKTR	New	NEKTAR THERAPEUTICS	$5,535,000	–	239,000	–	0.16%	–
PRVL	New	PREVAIL THERAPEUTICS INC	$5,513,000	–	370,000	–	0.15%	–
TCRR	New	TCR2 THERAPEUTICS INC	$5,376,000	–	350,000	–	0.15%	–
SLDB	New	SOLID BIOSCIENCES INC	$5,274,000	–	1,800,000	–	0.15%	–
SYRS	New	SYROS PHARMACEUTICALS INC	$5,223,000	–	490,000	–	0.15%	–
ORIC	New	ORIC PHARMACEUTICALS INC	$5,060,000	–	150,000	–	0.14%	–
NTLA	New	INTELLIA THERAPEUTICS INC	$5,024,000	–	239,000	–	0.14%	–
AXLA	New	AXCELLA HEALTH INC	$4,977,000	–	900,000	–	0.14%	–
RNA	New	AVIDITY BIOSCIENCES INC	$4,946,000	–	175,000	–	0.14%	–
ALEC	New	ALECTOR INC	$4,888,000	–	200,000	–	0.14%	–
ZNTL	New	ZENTALIS PHARMACEUTICALS INC	$4,418,000	–	92,000	–	0.12%	–
YI	New	111 INCads	$4,128,000	–	650,000	–	0.12%	–
PRTA	New	PROTHENA CORP PLC	$3,870,000	–	370,000	–	0.11%	–
KLDO	New	KALEIDO BIOSCIENCES INC	$3,719,000	–	500,500	–	0.10%	–
IDYA	New	IDEAYA BIOSCIENCES INC	$3,401,000	–	239,304	–	0.10%	–
MGTA	New	MAGENTA THERAPEUTICS INC	$3,380,000	–	450,000	–	0.10%	–
CLVS	New	CLOVIS ONCOLOGY INCcall	$3,375,000	–	500,000	–	0.09%	–
EVLO	New	EVELO BIOSCIENCES INC	$3,267,000	–	666,666	–	0.09%	–
MEIP	New	MEI PHARMA INC	$2,949,000	–	714,000	–	0.08%	–
NERV	New	MINERVA NEUROSCIENCES INC	$2,888,000	–	800,000	–	0.08%	–
CYRX	New	CRYOPORT INC	$2,692,000	–	89,000	–	0.08%	–
PTGX	New	PROTAGONIST THERAPEUTICS INC	$2,472,000	–	140,000	–	0.07%	–
ORTX	New	ORCHARD THERAPEUTICS PLCads	$2,220,000	–	370,000	–	0.06%	–
ADRO	New	ADURO BIOTECH INC	$2,195,000	–	950,000	–	0.06%	–
TORC	New	RESTORBIO INC	$2,049,000	–	953,000	–	0.06%	–
XLE	New	SELECT SECTOR SPDR TRcall	$1,893,000	–	50,000	–	0.05%	–
VXRT	New	VAXART INC	$1,770,000	–	200,000	–	0.05%	–
CRIS	New	CURIS INC	$1,789,000	–	1,478,662	–	0.05%	–
CTMX	New	CYTOMX THERAPEUTICS INC	$1,566,000	–	188,000	–	0.04%	–
BLU	New	BELLUS HEALTH INC NEW	$1,479,000	–	143,763	–	0.04%	–
IRWD	New	IRONWOOD PHARMACEUTICALS INC	$1,141,000	–	110,532	–	0.03%	–
CDTX	New	CIDARA THERAPEUTICS INC	$873,000	–	236,500	–	0.02%	–
RIGL	New	RIGEL PHARMACEUTICALS INC	$619,000	–	338,000	–	0.02%	–

Q4 2019

			Value		Shares		↓ Weighting
AVRO	Exit	AVROBIO INC	$0	–	-23,449	–	-0.01%	–
IRWD	Exit	IRONWOOD PHARMACEUTICALS INC	$0	–	-110,532	–	-0.04%	–
ADRO	Exit	ADURO BIOTECH INC	$0	–	-1,000,000	–	-0.04%	–
AKBA	Exit	AKEBIA THERAPEUTICS INC	$0	–	-425,000	–	-0.07%	–
SQ	Exit	SQUARE INCcl a	$0	–	-30,000	–	-0.08%	–
CLVS	Exit	CLOVIS ONCOLOGY INC	$0	–	-500,000	–	-0.08%	–
GRTS	Exit	GRITSTONE ONCOLOGY INC	$0	–	-250,000	–	-0.09%	–
AGLE	Exit	AEGLEA BIOTHERAPEUTICS INC	$0	–	-300,000	–	-0.09%	–
TWST	Exit	TWIST BIOSCIENCE CORP	$0	–	-100,000	–	-0.10%	–
VKTX	Exit	VIKING THERAPEUTICS INC	$0	–	-350,000	–	-0.10%	–
AXLA	Exit	AXCELLA HEALTH INC	$0	–	-450,000	–	-0.10%	–
NIO	Exit	NIO INCcall	$0	–	-1,750,000	–	-0.11%	–
ALLO	Exit	ALLOGENE THERAPEUTICS INC	$0	–	-100,000	–	-0.11%	–
ARAV	Exit	ARAVIVE INC	$0	–	-400,000	–	-0.12%	–
NIO	Exit	NIO INCsponsored ads	$0	–	-2,000,000	–	-0.12%	–
YI	Exit	111 INCads	$0	–	-650,000	–	-0.13%	–
ALEC	Exit	ALECTOR INC	$0	–	-225,000	–	-0.13%	–
DOYU	Exit	DOUYU INTERNATIONAL HLDNGS Lsponsored ads	$0	–	-400,000	–	-0.13%	–
IGMS	Exit	IGM BIOSCIENCES INC	$0	–	-200,000	–	-0.14%	–
SELB	Exit	SELECTA BIOSCIENCES INC	$0	–	-2,100,000	–	-0.15%	–
SGMO	Exit	SANGAMO THERAPEUTICS INC	$0	–	-405,000	–	-0.15%	–
STML	Exit	STEMLINE THERAPEUTICS INC	$0	–	-360,000	–	-0.15%	–
KURA	Exit	KURA ONCOLOGY INC	$0	–	-250,000	–	-0.15%	–
FOLD	Exit	AMICUS THERAPEUTICS INCcall	$0	–	-500,000	–	-0.16%	–
ORTX	Exit	ORCHARD THERAPEUTICS PLCads	$0	–	-350,000	–	-0.17%	–
BBIO	Exit	BRIDGEBIO PHARMA INC	$0	–	-200,000	–	-0.17%	–
TORC	Exit	RESTORBIO INC	$0	–	-500,000	–	-0.18%	–
LGFA	Exit	LIONS GATE ENTMNT CORPcall	$0	–	-500,000	–	-0.18%	–
ADPT	Exit	ADAPTIVE BIOTECHNOLOGIES COR	$0	–	-150,000	–	-0.19%	–
ACIU	Exit	AC IMMUNE SA	$0	–	-1,000,000	–	-0.20%	–
TGTX	Exit	TG THERAPEUTICS INC	$0	–	-900,000	–	-0.20%	–
RGNX	Exit	REGENXBIO INC	$0	–	-145,000	–	-0.21%	–
KRYS	Exit	KRYSTAL BIOTECH INC	$0	–	-150,000	–	-0.21%	–
SPRO	Exit	SPERO THERAPEUTICS INC	$0	–	-540,000	–	-0.23%	–
ARQL	Exit	ARQULE INC	$0	–	-850,000	–	-0.24%	–
DNLI	Exit	DENALI THERAPEUTICS INC	$0	–	-400,000	–	-0.25%	–
AUTL	Exit	AUTOLUS THERAPEUTICS PLCsponsored ads	$0	–	-500,000	–	-0.25%	–
AGEN	Exit	AGENUS INC	$0	–	-2,500,000	–	-0.26%	–
FGEN	Exit	FIBROGEN INC	$0	–	-180,000	–	-0.27%	–
SWTX	Exit	SPRINGWORKS THERAPEUTICS INC	$0	–	-308,526	–	-0.27%	–
KLDO	Exit	KALEIDO BIOSCIENCES INC	$0	–	-900,500	–	-0.27%	–
TCRR	Exit	TCR2 THERAPEUTICS INC	$0	–	-471,846	–	-0.28%	–
TBIO	Exit	TRANSLATE BIO INC	$0	–	-750,000	–	-0.30%	–
PRQR	Exit	PROQR THRAPEUTICS N V	$0	–	-1,300,000	–	-0.30%	–
NERV	Exit	MINERVA NEUROSCIENCES INC	$0	–	-1,000,000	–	-0.31%	–
MRNA	Exit	MODERNA INCcall	$0	–	-500,000	–	-0.32%	–
REPL	Exit	REPLIMUNE GROUP INC	$0	–	-600,000	–	-0.33%	–
HOOK	Exit	HOOKIPA PHARMA INC	$0	–	-1,134,616	–	-0.34%	–
MRUS	Exit	MERUS N V	$0	–	-500,000	–	-0.36%	–
ALBO	Exit	ALBIREO PHARMA INC	$0	–	-450,200	–	-0.36%	–
NKTR	Exit	NEKTAR THERAPEUTICS	$0	–	-500,000	–	-0.36%	–
BLUE	Exit	BLUEBIRD BIO INC	$0	–	-100,000	–	-0.37%	–
AXDX	Exit	ACCELERATE DIAGNOSTICS INC	$0	–	-500,000	–	-0.37%	–
BOLD	Exit	AUDENTES THERAPEUTICS INC	$0	–	-350,000	–	-0.39%	–
FIS	Exit	FIDELITY NATL INFORMATION SV	$0	–	-75,000	–	-0.40%	–
DLPH	Exit	DELPHI TECHNOLOGIES PLCcall	$0	–	-750,000	–	-0.40%	–
XNCR	Exit	XENCOR INC	$0	–	-300,000	–	-0.41%	–
STNE	Exit	STONECO LTD	$0	–	-300,000	–	-0.42%	–
YMAB	Exit	Y MABS THERAPEUTICS INC	$0	–	-400,000	–	-0.42%	–
NKTR	Exit	NEKTAR THERAPEUTICScall	$0	–	-600,000	–	-0.44%	–
TCDA	Exit	TRICIDA INC	$0	–	-360,000	–	-0.45%	–
REAL	Exit	THE REALREAL INC	$0	–	-565,000	–	-0.51%	–
IOVA	Exit	IOVANCE BIOTHERAPEUTICS INC	$0	–	-700,000	–	-0.51%	–
AGIO	Exit	AGIOS PHARMACEUTICALS INC	$0	–	-400,000	–	-0.52%	–
AAL	Exit	AMERICAN AIRLS GROUP INCcall	$0	–	-500,000	–	-0.54%	–
DRNA	Exit	DICERNA PHARMACEUTICALS INC	$0	–	-1,000,000	–	-0.58%	–
ASND	Exit	ASCENDIS PHARMA A Ssponsored adr	$0	–	-150,000	–	-0.58%	–
TPTX	Exit	TURNING POINT THERAPEUTICS I	$0	–	-400,000	–	-0.60%	–
UBER	Exit	UBER TECHNOLOGIES INC	$0	–	-500,000	–	-0.61%	–
EPZM	Exit	EPIZYME INC	$0	–	-1,500,000	–	-0.62%	–
MRTX	Exit	MIRATI THERAPEUTICS INC	$0	–	-200,000	–	-0.62%	–
CYCN	Exit	CYCLERION THERAPEUTICS INC	$0	–	-1,361,584	–	-0.66%	–
BABA	Exit	ALIBABA GROUP HLDG LTDcall	$0	–	-100,000	–	-0.67%	–
DCPH	Exit	DECIPHERA PHARMACEUTICALS IN	$0	–	-500,000	–	-0.68%	–
GBT	Exit	GLOBAL BLOOD THERAPEUTICS IN	$0	–	-350,000	–	-0.68%	–
SLDB	Exit	SOLID BIOSCIENCES INC	$0	–	-1,700,000	–	-0.70%	–
INCY	Exit	INCYTE CORPcall	$0	–	-250,000	–	-0.74%	–
XBI	Exit	SPDR SERIES TRUSTcall	$0	–	-250,000	–	-0.76%	–
Z	Exit	ZILLOW GROUP INCcl c cap stk	$0	–	-650,000	–	-0.78%	–
FOLD	Exit	AMICUS THERAPEUTICS INC	$0	–	-2,500,000	–	-0.80%	–
SRRK	Exit	SCHOLAR ROCK HLDG CORP	$0	–	-2,346,040	–	-0.84%	–
SAGE	Exit	SAGE THERAPEUTICS INC	$0	–	-150,000	–	-0.84%	–
ATRA	Exit	ATARA BIOTHERAPEUTICS INC	$0	–	-1,500,000	–	-0.85%	–
RUBY	Exit	RUBIUS THERAPEUTICS INC	$0	–	-2,833,791	–	-0.89%	–
ARGX	Exit	ARGENX SEsponsored adr	$0	–	-200,000	–	-0.91%	–
GOSS	Exit	GOSSAMER BIO INC	$0	–	-1,608,968	–	-1.08%	–
FATE	Exit	FATE THERAPEUTICS INC	$0	–	-2,000,000	–	-1.24%	–
MORF	Exit	MORPHIC HLDG INC	$0	–	-1,819,186	–	-1.32%	–
NVDA	Exit	NVIDIA CORP	$0	–	-200,000	–	-1.40%	–
BPMC	Exit	BLUEPRINT MEDICINES CORP	$0	–	-600,000	–	-1.77%	–
ALNY	Exit	ALNYLAM PHARMACEUTICALS INC	$0	–	-700,000	–	-2.26%	–
XLRN	Exit	ACCELERON PHARMA INC	$0	–	-1,500,000	–	-2.38%	–
MS	Exit	MORGAN STANLEYcall	$0	–	-1,500,000	–	-2.57%	–
MDCO	Exit	MEDICINES CO	$0	–	-1,400,000	–	-2.81%	–
MRNA	Exit	MODERNA INC	$0	–	-4,606,298	–	-2.94%	–
BABA	Exit	ALIBABA GROUP HLDG LTDsponsored ads	$0	–	-450,000	–	-3.02%	–
BGNE	Exit	BEIGENE LTDsponsored adr	$0	–	-650,000	–	-3.19%	–
BAC	Exit	BANK AMER CORPcall	$0	–	-3,000,000	–	-3.51%	–
AVTR	Exit	AVANTOR INC	$0	–	-6,000,000	–	-3.54%	–
BMY	Exit	BRISTOL MYERS SQUIBB COcall	$0	–	-3,500,000	–	-7.12%	–
LXRX	Exit	LEXICON PHARMACEUTICALS INC	$0	–	-60,240,864	–	-7.27%	–
WW	Exit	WW INTL INC	$0	–	-14,818,300	–	-22.47%	–

Q3 2019

			Value		Shares		↓ Weighting
WW	New	WW INTL INC	$560,428,000	–	14,818,300	–	22.47%	–
BMY	Buy	BRISTOL MYERS SQUIBB COcall	$177,485,000	+73.9%	3,500,000	+55.6%	7.12%	+72.4%
AVTR	Sell	AVANTOR INC	$88,200,000	-34.0%	6,000,000	-14.3%	3.54%	-34.6%
BAC	New	BANK AMER CORPcall	$87,510,000	–	3,000,000	–	3.51%	–
MDCO	Buy	MEDICINES CO	$70,000,000	+91.9%	1,400,000	+40.0%	2.81%	+90.3%
MS	New	MORGAN STANLEYcall	$64,005,000	–	1,500,000	–	2.57%	–
ALNY	Buy	ALNYLAM PHARMACEUTICALS INC	$56,294,000	+94.0%	700,000	+75.0%	2.26%	+92.2%
BPMC	Sell	BLUEPRINT MEDICINES CORP	$44,082,000	-37.7%	600,000	-20.0%	1.77%	-38.2%
NVDA	Sell	NVIDIA CORP	$34,814,000	-49.5%	200,000	-52.4%	1.40%	-50.0%
MORF	Buy	MORPHIC HLDG INC	$32,945,000	+232.4%	1,819,186	+263.8%	1.32%	+229.4%
FATE	Buy	FATE THERAPEUTICS INC	$31,060,000	+2.0%	2,000,000	+33.3%	1.24%	+1.1%
ARGX	Sell	ARGENX SEsponsored adr	$22,792,000	-26.8%	200,000	-9.1%	0.91%	-27.5%
ATRA	Buy	ATARA BIOTHERAPEUTICS INC	$21,180,000	-8.4%	1,500,000	+30.4%	0.85%	-9.2%
Z	Sell	ZILLOW GROUP INCcl c cap stk	$19,383,000	-58.2%	650,000	-35.0%	0.78%	-58.6%
XBI	New	SPDR SERIES TRUSTcall	$19,063,000	–	250,000	–	0.76%	–
SLDB	Buy	SOLID BIOSCIENCES INC	$17,578,000	+154.8%	1,700,000	+41.7%	0.70%	+152.7%
GBT	New	GLOBAL BLOOD THERAPEUTICS IN	$16,982,000	–	350,000	–	0.68%	–
DCPH	New	DECIPHERA PHARMACEUTICALS IN	$16,970,000	–	500,000	–	0.68%	–
BABA	Sell	ALIBABA GROUP HLDG LTDcall	$16,723,000	-50.7%	100,000	-50.0%	0.67%	-51.1%
MRTX	Buy	MIRATI THERAPEUTICS INC	$15,582,000	+0.9%	200,000	+33.3%	0.62%	0.0%
EPZM	Sell	EPIZYME INC	$15,473,000	-25.3%	1,500,000	-9.1%	0.62%	-26.0%
TPTX	Buy	TURNING POINT THERAPEUTICS I	$15,040,000	+84.8%	400,000	+100.0%	0.60%	+83.3%
AGIO	Sell	AGIOS PHARMACEUTICALS INC	$12,960,000	-48.0%	400,000	-20.0%	0.52%	-48.5%
REAL	Buy	THE REALREAL INC	$12,633,000	+2085.6%	565,000	+2725.0%	0.51%	+2104.3%
NKTR	Buy	NEKTAR THERAPEUTICScall	$10,929,000	+207.2%	600,000	+500.0%	0.44%	+204.2%
XNCR	Buy	XENCOR INC	$10,119,000	-10.1%	300,000	+9.1%	0.41%	-10.8%
DLPH	New	DELPHI TECHNOLOGIES PLCcall	$10,050,000	–	750,000	–	0.40%	–
FIS	New	FIDELITY NATL INFORMATION SV	$9,957,000	–	75,000	–	0.40%	–
AXDX	Buy	ACCELERATE DIAGNOSTICS INC	$9,285,000	-9.8%	500,000	+11.1%	0.37%	-10.6%
NKTR	Sell	NEKTAR THERAPEUTICS	$9,108,000	-63.4%	500,000	-28.6%	0.36%	-63.8%
ALBO	Buy	ALBIREO PHARMA INC	$9,004,000	-37.9%	450,200	+0.0%	0.36%	-38.5%
MRUS	Buy	MERUS N V	$8,910,000	+73.8%	500,000	+42.9%	0.36%	+72.5%
NERV	New	MINERVA NEUROSCIENCES INC	$7,750,000	–	1,000,000	–	0.31%	–
TCRR	Sell	TCR2 THERAPEUTICS INC	$7,092,000	+1.1%	471,846	-3.7%	0.28%	0.0%
SWTX	New	SPRINGWORKS THERAPEUTICS INC	$6,689,000	–	308,526	–	0.27%	–
ARQL	Buy	ARQULE INC	$6,095,000	-20.9%	850,000	+21.4%	0.24%	-21.8%
KRYS	Sell	KRYSTAL BIOTECH INC	$5,209,000	-56.9%	150,000	-50.0%	0.21%	-57.3%
ADPT	Sell	ADAPTIVE BIOTECHNOLOGIES COR	$4,635,000	-52.0%	150,000	-25.0%	0.19%	-52.4%
LGFA	New	LIONS GATE ENTMNT CORPcall	$4,625,000	–	500,000	–	0.18%	–
TORC	Buy	RESTORBIO INC	$4,420,000	+20.4%	500,000	+38.9%	0.18%	+18.8%
FOLD	New	AMICUS THERAPEUTICS INCcall	$4,010,000	–	500,000	–	0.16%	–
KURA	New	KURA ONCOLOGY INC	$3,793,000	–	250,000	–	0.15%	–
IGMS	New	IGM BIOSCIENCES INC	$3,550,000	–	200,000	–	0.14%	–
DOYU	New	DOUYU INTERNATIONAL HLDNGS Lsponsored ads	$3,276,000	–	400,000	–	0.13%	–
YI	Buy	111 INCads	$3,166,000	+26.5%	650,000	+44.4%	0.13%	+25.7%
NIO	Sell	NIO INCsponsored ads	$3,120,000	-74.8%	2,000,000	-58.8%	0.12%	-75.0%
ARAV	Buy	ARAVIVE INC	$3,000,000	+62.6%	400,000	+30.1%	0.12%	+60.0%
ALLO	Sell	ALLOGENE THERAPEUTICS INC	$2,726,000	-49.2%	100,000	-50.0%	0.11%	-49.8%
AXLA	Buy	AXCELLA HEALTH INC	$2,547,000	-29.8%	450,000	+15.5%	0.10%	-30.6%
VKTX	Buy	VIKING THERAPEUTICS INC	$2,408,000	+190.1%	350,000	+250.0%	0.10%	+185.3%
AGLE	Buy	AEGLEA BIOTHERAPEUTICS INC	$2,307,000	+99.4%	300,000	+77.6%	0.09%	+95.7%
GRTS	Sell	GRITSTONE ONCOLOGY INC	$2,159,000	-61.2%	250,000	-50.0%	0.09%	-61.3%
CLVS	New	CLOVIS ONCOLOGY INC	$1,965,000	–	500,000	–	0.08%	–
SQ	New	SQUARE INCcl a	$1,859,000	–	30,000	–	0.08%	–
AVRO	Sell	AVROBIO INC	$331,000	-77.4%	23,449	-73.9%	0.01%	-78.0%
MGTA	Exit	MAGENTA THERAPEUTICS INC	$0	–	-23,524	–	-0.01%	–
NGM	Exit	NGM BIOPHARMACEUTICALS INC	$0	–	-100,000	–	-0.06%	–
RCUS	Exit	ARCUS BIOSCIENCES INC	$0	–	-270,000	–	-0.09%	–
MDGL	Exit	MADRIGAL PHARMACEUTICALS INC	$0	–	-35,000	–	-0.15%	–
FTDR	Exit	FRONTDOOR INC	$0	–	-100,000	–	-0.18%	–
CRSP	Exit	CRISPR THERAPEUTICS AGnamen akt	$0	–	-100,000	–	-0.19%	–
AGIO	Exit	AGIOS PHARMACEUTICALS INCcall	$0	–	-100,000	–	-0.20%	–
RCKT	Exit	ROCKET PHARMACEUTICALS INC	$0	–	-360,000	–	-0.22%	–
CRWD	Exit	CROWDSTRIKE HLDGS INCcl a	$0	–	-100,000	–	-0.28%	–
ALDR	Exit	ALDER BIOPHARMACEUTICALS INC	$0	–	-850,000	–	-0.40%	–
ALNY	Exit	ALNYLAM PHARMACEUTICALS INCcall	$0	–	-150,000	–	-0.44%	–
CHNG	Exit	CHANGE HEALTHCARE INC	$0	–	-750,000	–	-0.44%	–
HTHT	Exit	HUAZHU GROUP LTDsponsored ads	$0	–	-350,000	–	-0.51%	–
NVDA	Exit	NVIDIA CORPcall	$0	–	-100,000	–	-0.66%	–
NBIX	Exit	NEUROCRINE BIOSCIENCES INCcall	$0	–	-200,000	–	-0.68%	–
MLCO	Exit	MELCO RESORTS AND ENTMT LTDcall	$0	–	-1,000,000	–	-0.88%	–
GM	Exit	GENERAL MTRS COcall	$0	–	-1,000,000	–	-1.56%	–
WW	Exit	WEIGHT WATCHERS INTL INC NEW	$0	–	-14,818,300	–	-11.45%	–

Q2 2019

			Value		Shares		↓ Weighting
LXRX	New	LEXICON PHARMACEUTICALS INC	$378,915,000	–	60,240,864	–	15.32%	–
WW	New	WEIGHT WATCHERS INTL INC NEW	$283,030,000	–	14,818,300	–	11.45%	–
AVTR	New	AVANTOR INC	$133,630,000	–	7,000,000	–	5.40%	–
BMY	New	BRISTOL MYERS SQUIBB COcall	$102,038,000	–	2,250,000	–	4.13%	–
BGNE	New	BEIGENE LTDsponsored adr	$80,568,000	–	650,000	–	3.26%	–
BABA	New	ALIBABA GROUP HLDG LTDsponsored ads	$76,253,000	–	450,000	–	3.08%	–
BPMC	New	BLUEPRINT MEDICINES CORP	$70,748,000	–	750,000	–	2.86%	–
NVDA	New	NVIDIA CORP	$68,977,000	–	420,000	–	2.79%	–
MRNA	New	MODERNA INC	$67,436,000	–	4,606,298	–	2.73%	–
XLRN	New	ACCELERON PHARMA INC	$61,620,000	–	1,500,000	–	2.49%	–
Z	New	ZILLOW GROUP INCcl c cap stk	$46,390,000	–	1,000,000	–	1.88%	–
RUBY	New	RUBIUS THERAPEUTICS INC	$44,576,000	–	2,833,791	–	1.80%	–
GM	New	GENERAL MTRS COcall	$38,530,000	–	1,000,000	–	1.56%	–
SRRK	New	SCHOLAR ROCK HLDG CORP	$37,208,000	–	2,346,040	–	1.50%	–
MDCO	New	MEDICINES CO	$36,470,000	–	1,000,000	–	1.48%	–
GOSS	New	GOSSAMER BIO INC	$35,687,000	–	1,608,968	–	1.44%	–
BABA	New	ALIBABA GROUP HLDG LTDcall	$33,890,000	–	200,000	–	1.37%	–
FOLD	New	AMICUS THERAPEUTICS INC	$31,200,000	–	2,500,000	–	1.26%	–
ARGX	New	ARGENX SEsponsored adr	$31,148,000	–	220,000	–	1.26%	–
FATE	New	FATE THERAPEUTICS INC	$30,450,000	–	1,500,000	–	1.23%	–
ALNY	New	ALNYLAM PHARMACEUTICALS INC	$29,024,000	–	400,000	–	1.17%	–
SAGE	New	SAGE THERAPEUTICS INC	$27,464,000	–	150,000	–	1.11%	–
AGIO	New	AGIOS PHARMACEUTICALS INC	$24,940,000	–	500,000	–	1.01%	–
NKTR	New	NEKTAR THERAPEUTICS	$24,906,000	–	700,000	–	1.01%	–
UBER	New	UBER TECHNOLOGIES INC	$23,190,000	–	500,000	–	0.94%	–
ATRA	New	ATARA BIOTHERAPEUTICS INC	$23,127,000	–	1,150,000	–	0.94%	–
MLCO	New	MELCO RESORTS AND ENTMT LTDcall	$21,720,000	–	1,000,000	–	0.88%	–
INCY	New	INCYTE CORPcall	$21,240,000	–	250,000	–	0.86%	–
EPZM	New	EPIZYME INC	$20,708,000	–	1,650,000	–	0.84%	–
ASND	New	ASCENDIS PHARMA A Ssponsored adr	$17,273,000	–	150,000	–	0.70%	–
IOVA	New	IOVANCE BIOTHERAPEUTICS INC	$17,164,000	–	700,000	–	0.69%	–
NBIX	New	NEUROCRINE BIOSCIENCES INCcall	$16,886,000	–	200,000	–	0.68%	–
NVDA	New	NVIDIA CORPcall	$16,423,000	–	100,000	–	0.66%	–
AAL	New	AMERICAN AIRLS GROUP INCcall	$16,305,000	–	500,000	–	0.66%	–
DRNA	New	DICERNA PHARMACEUTICALS INC	$15,750,000	–	1,000,000	–	0.64%	–
CYCN	New	CYCLERION THERAPEUTICS INC	$15,590,000	–	1,361,584	–	0.63%	–
MRTX	New	MIRATI THERAPEUTICS INC	$15,450,000	–	150,000	–	0.62%	–
ALBO	New	ALBIREO PHARMA INC	$14,508,000	–	450,000	–	0.59%	–
TCDA	New	TRICIDA INC	$14,206,000	–	360,000	–	0.58%	–
BOLD	New	AUDENTES THERAPEUTICS INC	$13,251,000	–	350,000	–	0.54%	–
BLUE	New	BLUEBIRD BIO INC	$12,720,000	–	100,000	–	0.51%	–
HTHT	New	HUAZHU GROUP LTDsponsored ads	$12,688,000	–	350,000	–	0.51%	–
NIO	New	NIO INCsponsored ads	$12,368,000	–	4,850,000	–	0.50%	–
KRYS	New	KRYSTAL BIOTECH INC	$12,081,000	–	300,000	–	0.49%	–
PRQR	New	PROQR THRAPEUTICS N V	$11,830,000	–	1,300,000	–	0.48%	–
XNCR	New	XENCOR INC	$11,256,000	–	275,000	–	0.46%	–
CHNG	New	CHANGE HEALTHCARE INC	$10,950,000	–	750,000	–	0.44%	–
ALNY	New	ALNYLAM PHARMACEUTICALS INCcall	$10,884,000	–	150,000	–	0.44%	–
KLDO	New	KALEIDO BIOSCIENCES INC	$10,446,000	–	900,500	–	0.42%	–
AXDX	New	ACCELERATE DIAGNOSTICS INC	$10,296,000	–	450,000	–	0.42%	–
ALDR	New	ALDER BIOPHARMACEUTICALS INC	$10,005,000	–	850,000	–	0.40%	–
MORF	New	MORPHIC HLDG INC	$9,910,000	–	500,000	–	0.40%	–
ADPT	New	ADAPTIVE BIOTECHNOLOGIES COR	$9,660,000	–	200,000	–	0.39%	–
TBIO	New	TRANSLATE BIO INC	$9,473,000	–	750,000	–	0.38%	–
YMAB	New	Y MABS THERAPEUTICS INC	$9,148,000	–	400,000	–	0.37%	–
STNE	New	STONECO LTD	$8,874,000	–	300,000	–	0.36%	–
REPL	New	REPLIMUNE GROUP INC	$8,796,000	–	600,000	–	0.36%	–
DNLI	New	DENALI THERAPEUTICS INC	$8,304,000	–	400,000	–	0.34%	–
FGEN	New	FIBROGEN INC	$8,132,000	–	180,000	–	0.33%	–
TPTX	New	TURNING POINT THERAPEUTICS I	$8,140,000	–	200,000	–	0.33%	–
AUTL	New	AUTOLUS THERAPEUTICS PLCsponsored ads	$8,050,000	–	500,000	–	0.33%	–
TGTX	New	TG THERAPEUTICS INC	$7,785,000	–	900,000	–	0.32%	–
ARQL	New	ARQULE INC	$7,707,000	–	700,000	–	0.31%	–
HOOK	New	HOOKIPA PHARMA INC	$7,636,000	–	1,134,616	–	0.31%	–
AGEN	New	AGENUS INC	$7,500,000	–	2,500,000	–	0.30%	–
RGNX	New	REGENXBIO INC	$7,449,000	–	145,000	–	0.30%	–
MRNA	New	MODERNA INCcall	$7,320,000	–	500,000	–	0.30%	–
TCRR	New	TCR2 THERAPEUTICS INC	$7,012,000	–	490,000	–	0.28%	–
SLDB	New	SOLID BIOSCIENCES INC	$6,900,000	–	1,200,000	–	0.28%	–
CRWD	New	CROWDSTRIKE HLDGS INCcl a	$6,829,000	–	100,000	–	0.28%	–
SPRO	New	SPERO THERAPEUTICS INC	$6,215,000	–	540,000	–	0.25%	–
GRTS	New	GRITSTONE ONCOLOGY INC	$5,570,000	–	500,000	–	0.22%	–
ACIU	New	AC IMMUNE SA	$5,550,000	–	1,000,000	–	0.22%	–
STML	New	STEMLINE THERAPEUTICS INC	$5,515,000	–	360,000	–	0.22%	–
RCKT	New	ROCKET PHARMACEUTICALS INC	$5,400,000	–	360,000	–	0.22%	–
BBIO	New	BRIDGEBIO PHARMA INC	$5,394,000	–	200,000	–	0.22%	–
ALLO	New	ALLOGENE THERAPEUTICS INC	$5,370,000	–	200,000	–	0.22%	–
MRUS	New	MERUS N V	$5,128,000	–	350,000	–	0.21%	–
AGIO	New	AGIOS PHARMACEUTICALS INCcall	$4,988,000	–	100,000	–	0.20%	–
ORTX	New	ORCHARD THERAPEUTICS PLCads	$4,897,000	–	350,000	–	0.20%	–
CRSP	New	CRISPR THERAPEUTICS AGnamen akt	$4,710,000	–	100,000	–	0.19%	–
NIO	New	NIO INCcall	$4,463,000	–	1,750,000	–	0.18%	–
FTDR	New	FRONTDOOR INC	$4,355,000	–	100,000	–	0.18%	–
SGMO	New	SANGAMO THERAPEUTICS INC	$4,362,000	–	405,000	–	0.18%	–
ALEC	New	ALECTOR INC	$4,275,000	–	225,000	–	0.17%	–
SELB	New	SELECTA BIOSCIENCES INC	$3,759,000	–	2,100,000	–	0.15%	–
TORC	New	RESTORBIO INC	$3,672,000	–	360,000	–	0.15%	–
MDGL	New	MADRIGAL PHARMACEUTICALS INC	$3,668,000	–	35,000	–	0.15%	–
AXLA	New	AXCELLA HEALTH INC	$3,628,000	–	389,741	–	0.15%	–
NKTR	New	NEKTAR THERAPEUTICScall	$3,558,000	–	100,000	–	0.14%	–
TWST	New	TWIST BIOSCIENCE CORP	$2,901,000	–	100,000	–	0.12%	–
YI	New	111 INCads	$2,502,000	–	450,000	–	0.10%	–
RCUS	New	ARCUS BIOSCIENCES INC	$2,147,000	–	270,000	–	0.09%	–
AKBA	New	AKEBIA THERAPEUTICS INC	$2,057,000	–	425,000	–	0.08%	–
ARAV	New	ARAVIVE INC	$1,845,000	–	307,466	–	0.08%	–
ADRO	New	ADURO BIOTECH INC	$1,540,000	–	1,000,000	–	0.06%	–
AVRO	New	AVROBIO INC	$1,463,000	–	90,000	–	0.06%	–
NGM	New	NGM BIOPHARMACEUTICALS INC	$1,464,000	–	100,000	–	0.06%	–
IRWD	New	IRONWOOD PHARMACEUTICALS INC	$1,209,000	–	110,532	–	0.05%	–
AGLE	New	AEGLEA BIOTHERAPEUTICS INC	$1,157,000	–	168,954	–	0.05%	–
VKTX	New	VIKING THERAPEUTICS INC	$830,000	–	100,000	–	0.03%	–
REAL	New	THE REALREAL INC	$578,000	–	20,000	–	0.02%	–
MGTA	New	MAGENTA THERAPEUTICS INC	$347,000	–	23,524	–	0.01%	–

Q4 2018

			Value		Shares		↓ Weighting
OCX	Exit	ONCOCYTE CORPORATION	$0	–	-150,000	–	-0.01%	–
LIFE	Exit	ATYR PHARMA INC	$0	–	-500,000	–	-0.01%	–
NVLNF	Exit	NOVELION THERAPEUTICS INC	$0	–	-256,400	–	-0.02%	–
UBX	Exit	UNITY BIOTECHNOLOGY INC	$0	–	-50,000	–	-0.02%	–
	Exit	TRILLIUM THERAPEUTICS INC	$0	–	-150,000	–	-0.02%	–
NVAX	Exit	NOVAVAX INC	$0	–	-500,000	–	-0.02%	–
IRWD	Exit	IRONWOOD PHARMACEUTICALS INC	$0	–	-110,532	–	-0.05%	–
TGTX	Exit	TG THERAPEUTICS INC	$0	–	-400,000	–	-0.06%	–
FIXX	Exit	HOMOLOGY MEDICINES INC	$0	–	-100,000	–	-0.06%	–
MGTA	Exit	MAGENTA THERAPEUTICS INC	$0	–	-200,000	–	-0.06%	–
ADVM	Exit	ADVERUM BIOTECHNOLOGIES INC	$0	–	-400,000	–	-0.06%	–
NTLA	Exit	INTELLIA THERAPEUTICS INC	$0	–	-90,000	–	-0.07%	–
KRYS	Exit	KRYSTAL BIOTECH INC	$0	–	-150,000	–	-0.07%	–
MGEN	Exit	MIRAGEN THERAPEUTICS INC	$0	–	-500,000	–	-0.07%	–
GRTS	Exit	GRITSTONE ONCOLOGY INC	$0	–	-200,000	–	-0.07%	–
SYBX	Exit	SYNLOGIC INC	$0	–	-200,000	–	-0.07%	–
CNAT	Exit	CONATUS PHARMACEUTICALS INC	$0	–	-500,000	–	-0.08%	–
TCDA	Exit	TRICIDA INC	$0	–	-100,000	–	-0.08%	–
FLEX	Exit	FLEX LTDord	$0	–	-250,000	–	-0.08%	–
XENE	Exit	XENON PHARMACEUTICALS INC	$0	–	-250,000	–	-0.09%	–
ELAN	Exit	ELANCO ANIMAL HEALTH INC	$0	–	-100,000	–	-0.09%	–
CMRX	Exit	CHIMERIX INC	$0	–	-1,000,000	–	-0.10%	–
YMAB	Exit	Y MABS THERAPEUTICS INC	$0	–	-150,000	–	-0.10%	–
ADRO	Exit	ADURO BIOTECH INC	$0	–	-550,000	–	-0.10%	–
LJPC	Exit	LA JOLLA PHARMACEUTICAL CO	$0	–	-200,000	–	-0.10%	–
RCUS	Exit	ARCUS BIOSCIENCES INC	$0	–	-300,000	–	-0.11%	–
AKBA	Exit	AKEBIA THERAPEUTICS INC	$0	–	-475,000	–	-0.11%	–
CRSP	Exit	CRISPR THERAPEUTICS AGnamen akt	$0	–	-100,000	–	-0.12%	–
ARPO	Exit	AERPIO PHARMACEUTICALS INC	$0	–	-1,558,400	–	-0.12%	–
MRNS	Exit	MARINUS PHARMACEUTICALS INC	$0	–	-500,000	–	-0.13%	–
SGMO	Exit	SANGAMO THERAPEUTICS INC	$0	–	-300,000	–	-0.13%	–
AVRO	Exit	AVROBIO INC	$0	–	-100,000	–	-0.14%	–
CRNX	Exit	CRINETICS PHARMACEUTICALS IN	$0	–	-200,000	–	-0.15%	–
LOGM	Exit	LOGMEIN INC	$0	–	-65,000	–	-0.15%	–
AGEN	Exit	AGENUS INC	$0	–	-2,750,000	–	-0.15%	–
ACIU	Exit	AC IMMUNE SA	$0	–	-750,000	–	-0.16%	–
TBIO	Exit	TRANSLATE BIO INC	$0	–	-600,000	–	-0.16%	–
YI	Exit	111 INCads	$0	–	-450,000	–	-0.16%	–
SPRO	Exit	SPERO THERAPEUTICS INC	$0	–	-600,000	–	-0.16%	–
DRNA	Exit	DICERNA PHARMACEUTICALS INC	$0	–	-425,000	–	-0.17%	–
STML	Exit	STEMLINE THERAPEUTICS INC	$0	–	-400,000	–	-0.17%	–
REPL	Exit	REPLIMUNE GROUP INC	$0	–	-450,000	–	-0.19%	–
TORC	Exit	RESTORBIO INC	$0	–	-500,000	–	-0.20%	–
CMTA	Exit	CLEMENTIA PHARMACEUTICALS IN	$0	–	-692,000	–	-0.20%	–
IOVA	Exit	IOVANCE BIOTHERAPEUTICS INC	$0	–	-700,000	–	-0.20%	–
SELB	Exit	SELECTA BIOSCIENCES INC	$0	–	-561,540	–	-0.23%	–
ALNY	Exit	ALNYLAM PHARMACEUTICALS INCcall	$0	–	-100,000	–	-0.23%	–
CBAY	Exit	CYMABAY THERAPEUTICS INC	$0	–	-800,000	–	-0.23%	–
ZFGN	Exit	ZAFGEN INC	$0	–	-800,000	–	-0.24%	–
RCKT	Exit	ROCKET PHARMACEUTICALS INC	$0	–	-400,000	–	-0.26%	–
BOLD	Exit	AUDENTES THERAPEUTICS INC	$0	–	-250,000	–	-0.26%	–
NIO	Exit	NIO INCspon ads	$0	–	-1,500,000	–	-0.27%	–
SLDB	Exit	SOLID BIOSCIENCES INC	$0	–	-225,000	–	-0.28%	–
MDGL	Exit	MADRIGAL PHARMACEUTICALS INC	$0	–	-50,000	–	-0.28%	–
BABA	Exit	ALIBABA GROUP HLDG LTDsponsored ads	$0	–	-65,000	–	-0.28%	–
DNLI	Exit	DENALI THERAPEUTICS INC	$0	–	-500,000	–	-0.28%	–
RGNX	Exit	REGENXBIO INC	$0	–	-150,000	–	-0.30%	–
AXDX	Exit	ACCELERATE DIAGNOSTICS INC	$0	–	-500,000	–	-0.30%	–
AXDX	Exit	ACCELERATE DIAGNOSTICS INCcall	$0	–	-500,000	–	-0.30%	–
MDCO	Exit	MEDICINES CO	$0	–	-400,000	–	-0.31%	–
FOLD	Exit	AMICUS THERAPEUTICS INCcall	$0	–	-1,000,000	–	-0.32%	–
NKTR	Exit	NEKTAR THERAPEUTICScall	$0	–	-200,000	–	-0.32%	–
AAL	Exit	AMERICAN AIRLS GROUP INCcall	$0	–	-300,000	–	-0.32%	–
WYNN	Exit	WYNN RESORTS LTDcall	$0	–	-100,000	–	-0.33%	–
FCX	Exit	FREEPORT-MCMORAN INCcall	$0	–	-1,000,000	–	-0.36%	–
ARGX	Exit	ARGENX SEsponsored adr	$0	–	-185,000	–	-0.36%	–
SAGE	Exit	SAGE THERAPEUTICS INC	$0	–	-100,000	–	-0.37%	–
FGEN	Exit	FIBROGEN INC	$0	–	-250,000	–	-0.40%	–
AUTL	Exit	AUTOLUS THERAPEUTICS PLCspon ads	$0	–	-500,000	–	-0.40%	–
BABA	Exit	ALIBABA GROUP HLDG LTDcall	$0	–	-100,000	–	-0.43%	–
ALBO	Exit	ALBIREO PHARMA INC	$0	–	-500,000	–	-0.43%	–
IFRX	Exit	INFLARX NV	$0	–	-500,000	–	-0.45%	–
MDCO	Exit	MEDICINES COcall	$0	–	-600,000	–	-0.47%	–
C	Exit	CITIGROUP INCcall	$0	–	-250,000	–	-0.47%	–
MU	Exit	MICRON TECHNOLOGY INCcall	$0	–	-400,000	–	-0.47%	–
XBI	Exit	SPDR SERIES TRUSTcall	$0	–	-200,000	–	-0.50%	–
BMRN	Exit	BIOMARIN PHARMACEUTICAL INCcall	$0	–	-200,000	–	-0.50%	–
XNCR	Exit	XENCOR INC	$0	–	-500,000	–	-0.51%	–
TSRO	Exit	TESARO INCcall	$0	–	-500,000	–	-0.51%	–
ZGNX	Exit	ZOGENIX INC	$0	–	-400,000	–	-0.52%	–
AGIO	Exit	AGIOS PHARMACEUTICALS INC	$0	–	-300,000	–	-0.60%	–
PRQR	Exit	PROQR THRAPEUTICS N V	$0	–	-1,300,000	–	-0.65%	–
BLUE	Exit	BLUEBIRD BIO INC	$0	–	-175,000	–	-0.66%	–
ARRY	Exit	ARRAY BIOPHARMA INC	$0	–	-1,900,000	–	-0.75%	–
ANAB	Exit	ANAPTYSBIO INC	$0	–	-300,000	–	-0.78%	–
TSRO	Exit	TESARO INC	$0	–	-800,000	–	-0.81%	–
FATE	Exit	FATE THERAPEUTICS INC	$0	–	-2,190,000	–	-0.93%	–
BPMC	Exit	BLUEPRINT MEDICINES CORP	$0	–	-500,000	–	-1.02%	–
ATRA	Exit	ATARA BIOTHERAPEUTICS INC	$0	–	-1,000,000	–	-1.08%	–
BMY	Exit	BRISTOL MYERS SQUIBB COcall	$0	–	-750,000	–	-1.21%	–
FOLD	Exit	AMICUS THERAPEUTICS INC	$0	–	-4,000,000	–	-1.26%	–
NKTR	Exit	NEKTAR THERAPEUTICS	$0	–	-800,000	–	-1.27%	–
ALNY	Exit	ALNYLAM PHARMACEUTICALS INC	$0	–	-600,000	–	-1.37%	–
XLRN	Exit	ACCELERON PHARMA INC	$0	–	-1,000,000	–	-1.49%	–
SRRK	Exit	SCHOLAR ROCK HLDG CORP	$0	–	-2,396,040	–	-1.60%	–
CELG	Exit	CELGENE CORPcall	$0	–	-750,000	–	-1.75%	–
RUBY	Exit	RUBIUS THERAPEUTICS, INC.	$0	–	-2,908,791	–	-1.82%	–
WFC	Exit	WELLS FARGO CO NEWcall	$0	–	-1,500,000	–	-2.05%	–
MS	Exit	MORGAN STANLEYcall	$0	–	-2,000,000	–	-2.42%	–
GM	Exit	GENERAL MTRS COcall	$0	–	-3,000,000	–	-2.63%	–
BGNE	Exit	BEIGENE LTDsponsored adr	$0	–	-600,000	–	-2.69%	–
BAC	Exit	BANK AMER CORPcall	$0	–	-4,500,000	–	-3.45%	–
GS	Exit	GOLDMAN SACHS GROUP INCcall	$0	–	-1,050,000	–	-6.12%	–
LXRX	Exit	LEXICON PHARMACEUTICALS INC	$0	–	-60,240,864	–	-16.72%	–
WW	Exit	WEIGHT WATCHERS INTL INC NEW	$0	–	-14,818,300	–	-27.75%	–

Q3 2018

			Value		Shares		↓ Weighting
WW	Sell	WEIGHT WATCHERS INTL INC NEW	$1,066,769,000	-49.3%	14,818,300	-28.8%	27.75%	-38.0%
GS	Buy	GOLDMAN SACHS GROUP INCcall	$235,452,000	+255.8%	1,050,000	+250.0%	6.12%	+335.6%
BAC	Sell	BANK AMER CORPcall	$132,570,000	-25.9%	4,500,000	-29.1%	3.45%	-9.4%
BGNE	Sell	BEIGENE LTDsponsored adr	$103,332,000	-0.4%	600,000	-11.1%	2.69%	+21.9%
GM	Buy	GENERAL MTRS COcall	$101,010,000	+70.9%	3,000,000	+100.0%	2.63%	+109.2%
MS	Buy	MORGAN STANLEYcall	$93,140,000	+31.0%	2,000,000	+33.3%	2.42%	+60.4%
WFC	Buy	WELLS FARGO CO NEWcall	$78,840,000	+42.2%	1,500,000	+50.0%	2.05%	+74.1%
RUBY	New	RUBIUS THERAPEUTICS, INC.	$69,811,000	–	2,908,791	–	1.82%	–
CELG	Sell	CELGENE CORPcall	$67,118,000	-57.7%	750,000	-62.5%	1.75%	-48.3%
ALNY	Sell	ALNYLAM PHARMACEUTICALS INC	$52,512,000	-18.0%	600,000	-7.7%	1.37%	+0.4%
NKTR	Sell	NEKTAR THERAPEUTICS	$48,768,000	+11.0%	800,000	-11.1%	1.27%	+35.9%
FOLD	Buy	AMICUS THERAPEUTICS INC	$48,360,000	+6.8%	4,000,000	+37.9%	1.26%	+30.6%
BMY	Sell	BRISTOL MYERS SQUIBB COcall	$46,560,000	-32.7%	750,000	-40.0%	1.21%	-17.6%
BPMC	Sell	BLUEPRINT MEDICINES CORP	$39,030,000	-12.2%	500,000	-28.6%	1.02%	+7.5%
FATE	Buy	FATE THERAPEUTICS INC	$35,675,000	+85.1%	2,190,000	+28.8%	0.93%	+126.3%
ANAB	Buy	ANAPTYSBIO INC	$29,931,000	+110.7%	300,000	+50.0%	0.78%	+157.9%
ARRY	Sell	ARRAY BIOPHARMA INC	$28,880,000	-13.9%	1,900,000	-5.0%	0.75%	+5.3%
BLUE	Buy	BLUEBIRD BIO INC	$25,550,000	-4.2%	175,000	+2.9%	0.66%	+17.3%
PRQR	Sell	PROQR THRAPEUTICS N V	$25,155,000	+129.7%	1,300,000	-13.3%	0.65%	+180.7%
AGIO	Sell	AGIOS PHARMACEUTICALS INC	$23,136,000	-21.5%	300,000	-14.3%	0.60%	-4.0%
ZGNX	Sell	ZOGENIX INC	$19,840,000	-10.2%	400,000	-20.0%	0.52%	+9.8%
TSRO	Buy	TESARO INCcall	$19,505,000	+25.3%	500,000	+42.9%	0.51%	+53.2%
XNCR	Buy	XENCOR INC	$19,485,000	+31.6%	500,000	+25.0%	0.51%	+61.0%
XBI	New	SPDR SERIES TRUSTcall	$19,174,000	–	200,000	–	0.50%	–
MU	New	MICRON TECHNOLOGY INCcall	$18,092,000	–	400,000	–	0.47%	–
C	New	CITIGROUP INCcall	$17,935,000	–	250,000	–	0.47%	–
MDCO	Sell	MEDICINES COcall	$17,946,000	-30.1%	600,000	-14.3%	0.47%	-14.5%
BABA	New	ALIBABA GROUP HLDG LTDcall	$16,476,000	–	100,000	–	0.43%	–
AUTL	Sell	AUTOLUS THERAPEUTICS PLCspon ads	$15,335,000	+9.0%	500,000	-4.8%	0.40%	+33.4%
ARGX	Buy	ARGENX SEsponsored adr	$14,030,000	+12.9%	185,000	+23.3%	0.36%	+38.3%
WYNN	New	WYNN RESORTS LTDcall	$12,706,000	–	100,000	–	0.33%	–
AAL	New	AMERICAN AIRLS GROUP INCcall	$12,399,000	–	300,000	–	0.32%	–
NKTR	Sell	NEKTAR THERAPEUTICScall	$12,192,000	-16.8%	200,000	-33.3%	0.32%	+1.9%
FOLD	Buy	AMICUS THERAPEUTICS INCcall	$12,090,000	+54.8%	1,000,000	+100.0%	0.32%	+89.8%
BABA	New	ALIBABA GROUP HLDG LTDsponsored ads	$10,709,000	–	65,000	–	0.28%	–
SLDB	Sell	SOLID BIOSCIENCES INC	$10,616,000	+19.2%	225,000	-10.0%	0.28%	+46.0%
NIO	New	NIO INCspon ads	$10,470,000	–	1,500,000	–	0.27%	–
BOLD	Buy	AUDENTES THERAPEUTICS INC	$9,898,000	+9.8%	250,000	+5.9%	0.26%	+34.4%
ZFGN	Sell	ZAFGEN INC	$9,352,000	-23.8%	800,000	-33.3%	0.24%	-6.9%
SELB	Buy	SELECTA BIOSCIENCES INC	$8,732,000	+31.8%	561,540	+12.3%	0.23%	+61.0%
CMTA	Buy	CLEMENTIA PHARMACEUTICALS IN	$7,716,000	+193.2%	692,000	+246.0%	0.20%	+258.9%
TORC	Sell	RESTORBIO INC	$7,570,000	+50.4%	500,000	-9.1%	0.20%	+84.1%
REPL	New	REPLIMUNE GROUP INC	$7,245,000	–	450,000	–	0.19%	–
SPRO	Buy	SPERO THERAPEUTICS INC	$6,306,000	+22.8%	600,000	+71.4%	0.16%	+50.5%
YI	New	111 INCads	$6,084,000	–	450,000	–	0.16%	–
TBIO	Buy	TRANSLATE BIO INC	$6,000,000	-5.1%	600,000	+20.0%	0.16%	+16.4%
ACIU	Buy	AC IMMUNE SA	$6,000,000	+7.3%	750,000	+25.0%	0.16%	+31.1%
LOGM	New	LOGMEIN INC	$5,792,000	–	65,000	–	0.15%	–
CRNX	New	CRINETICS PHARMACEUTICALS IN	$5,730,000	–	200,000	–	0.15%	–
AVRO	Sell	AVROBIO INC	$5,187,000	+45.3%	100,000	-20.0%	0.14%	+77.6%
SGMO	Buy	SANGAMO THERAPEUTICS INC	$5,085,000	+79.0%	300,000	+50.0%	0.13%	+120.0%
CRSP	Buy	CRISPR THERAPEUTICS AGnamen akt	$4,435,000	+51.0%	100,000	+100.0%	0.12%	+85.5%
LJPC	Sell	LA JOLLA PHARMACEUTICAL CO	$4,026,000	-44.8%	200,000	-20.0%	0.10%	-32.3%
YMAB	New	Y MABS THERAPEUTICS INC	$3,984,000	–	150,000	–	0.10%	–
CMRX	Buy	CHIMERIX INC	$3,890,000	+63.4%	1,000,000	+100.0%	0.10%	+98.0%
ELAN	New	ELANCO ANIMAL HEALTH INC	$3,489,000	–	100,000	–	0.09%	–
XENE	Buy	XENON PHARMACEUTICALS INC	$3,300,000	+139.1%	250,000	+66.7%	0.09%	+196.6%
FLEX	New	FLEX LTDord	$3,280,000	–	250,000	–	0.08%	–
CNAT	New	CONATUS PHARMACEUTICALS INC	$2,900,000	–	500,000	–	0.08%	–
GRTS	New	GRITSTONE ONCOLOGY INC	$2,848,000	–	200,000	–	0.07%	–
SYBX	Sell	SYNLOGIC INC	$2,842,000	-27.7%	200,000	-50.0%	0.07%	-11.9%
IRWD	Sell	IRONWOOD PHARMACEUTICALS INC	$2,040,000	-50.8%	110,532	-49.0%	0.05%	-39.8%
UBX	Sell	UNITY BIOTECHNOLOGY INC	$815,000	-72.9%	50,000	-75.0%	0.02%	-67.2%
SNDX	Exit	SYNDAX PHARMACEUTICALS INC	$0	–	-60,697	–	-0.01%	–
TOCA	Exit	TOCAGEN INC	$0	–	-100,000	–	-0.02%	–
SNNAQ	Exit	SIENNA BIOPHARMACEUTICALS IN	$0	–	-99,000	–	-0.03%	–
KNSA	Exit	KINIKSA PHARMACEUTICALS LTD	$0	–	-100,000	–	-0.04%	–
IDRA	Exit	IDERA PHARMACEUTICALS INC	$0	–	-2,750,000	–	-0.08%	–
DVAX	Exit	DYNAVAX TECHNOLOGIES CORPcall	$0	–	-250,000	–	-0.08%	–
WVE	Exit	WAVE LIFE SCIENCES LTD	$0	–	-100,000	–	-0.08%	–
GLYC	Exit	GLYCOMIMETICS INC	$0	–	-250,000	–	-0.09%	–
AGIO	Exit	AGIOS PHARMACEUTICALS INCcall	$0	–	-50,000	–	-0.09%	–
CLVS	Exit	CLOVIS ONCOLOGY INCcall	$0	–	-100,000	–	-0.10%	–
XLRN	Exit	ACCELERON PHARMA INCcall	$0	–	-100,000	–	-0.10%	–
VTL	Exit	VITAL THERAPIES INC	$0	–	-1,000,000	–	-0.15%	–
BLUE	Exit	BLUEBIRD BIO INCcall	$0	–	-50,000	–	-0.17%	–
GBT	Exit	GLOBAL BLOOD THERAPEUTICS IN	$0	–	-200,000	–	-0.19%	–
EXEL	Exit	EXELIXIS INCcall	$0	–	-500,000	–	-0.23%	–
BPMC	Exit	BLUEPRINT MEDICINES CORPcall	$0	–	-200,000	–	-0.27%	–
IBB	Exit	ISHARES TRcall	$0	–	-450,000	–	-1.05%	–

Q2 2018

			Value		Shares		↓ Weighting
WW	New	WEIGHT WATCHERS INTL INC NEW	$2,104,730,000	–	20,818,300	–	44.73%	–
LXRX	New	LEXICON PHARMACEUTICALS INC	$722,891,000	–	60,240,864	–	15.36%	–
BAC	New	BANK AMER CORPcall	$179,007,000	–	6,350,000	–	3.80%	–
CELG	New	CELGENE CORPcall	$158,840,000	–	2,000,000	–	3.38%	–
BGNE	New	BEIGENE LTDsponsored adr	$103,768,000	–	675,000	–	2.20%	–
MS	New	MORGAN STANLEYcall	$71,100,000	–	1,500,000	–	1.51%	–
BMY	New	BRISTOL MYERS SQUIBB COcall	$69,175,000	–	1,250,000	–	1.47%	–
GS	New	GOLDMAN SACHS GROUP INCcall	$66,171,000	–	300,000	–	1.41%	–
ALNY	New	ALNYLAM PHARMACEUTICALS INC	$64,019,000	–	650,000	–	1.36%	–
GM	New	GENERAL MTRS COcall	$59,100,000	–	1,500,000	–	1.26%	–
WFC	New	WELLS FARGO CO NEWcall	$55,440,000	–	1,000,000	–	1.18%	–
IBB	New	ISHARES TRcall	$49,419,000	–	450,000	–	1.05%	–
XLRN	New	ACCELERON PHARMA INC	$48,520,000	–	1,000,000	–	1.03%	–
FOLD	New	AMICUS THERAPEUTICS INC	$45,298,000	–	2,900,000	–	0.96%	–
BPMC	New	BLUEPRINT MEDICINES CORP	$44,436,000	–	700,000	–	0.94%	–
NKTR	New	NEKTAR THERAPEUTICS	$43,947,000	–	900,000	–	0.93%	–
SRRK	New	SCHOLAR ROCK HLDG CORP	$37,378,000	–	2,396,040	–	0.79%	–
ATRA	New	ATARA BIOTHERAPEUTICS INC	$36,750,000	–	1,000,000	–	0.78%	–
TSRO	New	TESARO INC	$35,576,000	–	800,000	–	0.76%	–
ARRY	New	ARRAY BIOPHARMA INC	$33,560,000	–	2,000,000	–	0.71%	–
AGIO	New	AGIOS PHARMACEUTICALS INC	$29,481,000	–	350,000	–	0.63%	–
BLUE	New	BLUEBIRD BIO INC	$26,682,000	–	170,000	–	0.57%	–
MDCO	New	MEDICINES COcall	$25,690,000	–	700,000	–	0.55%	–
ZGNX	New	ZOGENIX INC	$22,100,000	–	500,000	–	0.47%	–
FATE	New	FATE THERAPEUTICS INC	$19,278,000	–	1,700,000	–	0.41%	–
BMRN	New	BIOMARIN PHARMACEUTICAL INCcall	$18,840,000	–	200,000	–	0.40%	–
ALBO	New	ALBIREO PHARMA INC	$17,750,000	–	500,000	–	0.38%	–
FCX	New	FREEPORT-MCMORAN INCcall	$17,260,000	–	1,000,000	–	0.37%	–
IFRX	New	INFLARX NV	$16,125,000	–	500,000	–	0.34%	–
FGEN	New	FIBROGEN INC	$15,650,000	–	250,000	–	0.33%	–
SAGE	New	SAGE THERAPEUTICS INC	$15,653,000	–	100,000	–	0.33%	–
TSRO	New	TESARO INCcall	$15,565,000	–	350,000	–	0.33%	–
XNCR	New	XENCOR INC	$14,804,000	–	400,000	–	0.32%	–
MDCO	New	MEDICINES CO	$14,680,000	–	400,000	–	0.31%	–
NKTR	New	NEKTAR THERAPEUTICScall	$14,649,000	–	300,000	–	0.31%	–
ANAB	New	ANAPTYSBIO INC	$14,208,000	–	200,000	–	0.30%	–
AUTL	New	AUTOLUS THERAPEUTICS PLCspon ads	$14,065,000	–	525,000	–	0.30%	–
MDGL	New	MADRIGAL PHARMACEUTICALS INC	$13,985,000	–	50,000	–	0.30%	–
BPMC	New	BLUEPRINT MEDICINES CORPcall	$12,696,000	–	200,000	–	0.27%	–
ARGX	New	ARGENX SEsponsored adr	$12,429,000	–	150,000	–	0.26%	–
ZFGN	New	ZAFGEN INC	$12,276,000	–	1,200,000	–	0.26%	–
AXDX	New	ACCELERATE DIAGNOSTICS INC	$11,150,000	–	500,000	–	0.24%	–
AXDX	New	ACCELERATE DIAGNOSTICS INCcall	$11,150,000	–	500,000	–	0.24%	–
PRQR	New	PROQR THRAPEUTICS N V	$10,950,000	–	1,500,000	–	0.23%	–
RGNX	New	REGENXBIO INC	$10,763,000	–	150,000	–	0.23%	–
EXEL	New	EXELIXIS INCcall	$10,760,000	–	500,000	–	0.23%	–
CBAY	New	CYMABAY THERAPEUTICS INC	$10,736,000	–	800,000	–	0.23%	–
ALNY	New	ALNYLAM PHARMACEUTICALS INCcall	$9,849,000	–	100,000	–	0.21%	–
GBT	New	GLOBAL BLOOD THERAPEUTICS IN	$9,040,000	–	200,000	–	0.19%	–
BOLD	New	AUDENTES THERAPEUTICS INC	$9,018,000	–	236,000	–	0.19%	–
IOVA	New	IOVANCE BIOTHERAPEUTICS INC	$8,960,000	–	700,000	–	0.19%	–
SLDB	New	SOLID BIOSCIENCES INC	$8,908,000	–	250,000	–	0.19%	–
BLUE	New	BLUEBIRD BIO INCcall	$7,848,000	–	50,000	–	0.17%	–
RCKT	New	ROCKET PHARMACEUTICALS INC	$7,852,000	–	400,000	–	0.17%	–
FOLD	New	AMICUS THERAPEUTICS INCcall	$7,810,000	–	500,000	–	0.17%	–
DNLI	New	DENALI THERAPEUTICS INC	$7,625,000	–	500,000	–	0.16%	–
LJPC	New	LA JOLLA PHARMACEUTICAL CO	$7,293,000	–	250,000	–	0.16%	–
VTL	New	VITAL THERAPIES INC	$6,850,000	–	1,000,000	–	0.15%	–
SELB	New	SELECTA BIOSCIENCES INC	$6,625,000	–	500,000	–	0.14%	–
ARPO	New	AERPIO PHARMACEUTICALS INC	$6,467,000	–	1,558,400	–	0.14%	–
STML	New	STEMLINE THERAPEUTICS INC	$6,420,000	–	400,000	–	0.14%	–
TBIO	New	TRANSLATE BIO INC	$6,325,000	–	500,000	–	0.13%	–
AGEN	New	AGENUS INC	$6,243,000	–	2,750,000	–	0.13%	–
ACIU	New	AC IMMUNE SA	$5,592,000	–	600,000	–	0.12%	–
TGTX	New	TG THERAPEUTICS INC	$5,260,000	–	400,000	–	0.11%	–
DRNA	New	DICERNA PHARMACEUTICALS INC	$5,206,000	–	425,000	–	0.11%	–
SPRO	New	SPERO THERAPEUTICS INC	$5,135,000	–	350,000	–	0.11%	–
TORC	New	RESTORBIO INC	$5,033,000	–	550,000	–	0.11%	–
XLRN	New	ACCELERON PHARMA INCcall	$4,852,000	–	100,000	–	0.10%	–
AKBA	New	AKEBIA THERAPEUTICS INC	$4,741,000	–	475,000	–	0.10%	–
CLVS	New	CLOVIS ONCOLOGY INCcall	$4,547,000	–	100,000	–	0.10%	–
AGIO	New	AGIOS PHARMACEUTICALS INCcall	$4,212,000	–	50,000	–	0.09%	–
IRWD	New	IRONWOOD PHARMACEUTICALS INC	$4,147,000	–	216,879	–	0.09%	–
GLYC	New	GLYCOMIMETICS INC	$4,033,000	–	250,000	–	0.09%	–
SYBX	New	SYNLOGIC INC	$3,932,000	–	400,000	–	0.08%	–
ADRO	New	ADURO BIOTECH INC	$3,850,000	–	550,000	–	0.08%	–
WVE	New	WAVE LIFE SCIENCES LTD	$3,825,000	–	100,000	–	0.08%	–
DVAX	New	DYNAVAX TECHNOLOGIES CORPcall	$3,813,000	–	250,000	–	0.08%	–
RCUS	New	ARCUS BIOSCIENCES INC	$3,672,000	–	300,000	–	0.08%	–
IDRA	New	IDERA PHARMACEUTICALS INC	$3,630,000	–	2,750,000	–	0.08%	–
AVRO	New	AVROBIO INC	$3,570,000	–	125,000	–	0.08%	–
MRNS	New	MARINUS PHARMACEUTICALS INC	$3,535,000	–	500,000	–	0.08%	–
MGEN	New	MIRAGEN THERAPEUTICS INC	$3,205,000	–	500,000	–	0.07%	–
UBX	New	UNITY BIOTECHNOLOGY INC	$3,012,000	–	200,000	–	0.06%	–
TCDA	New	TRICIDA INC	$2,990,000	–	100,000	–	0.06%	–
CRSP	New	CRISPR THERAPEUTICS AGnamen akt	$2,938,000	–	50,000	–	0.06%	–
SGMO	New	SANGAMO THERAPEUTICS INC	$2,840,000	–	200,000	–	0.06%	–
MGTA	New	MAGENTA THERAPEUTICS INC	$2,700,000	–	200,000	–	0.06%	–
CMTA	New	CLEMENTIA PHARMACEUTICALS IN	$2,632,000	–	200,000	–	0.06%	–
NTLA	New	INTELLIA THERAPEUTICS INC	$2,462,000	–	90,000	–	0.05%	–
CMRX	New	CHIMERIX INC	$2,380,000	–	500,000	–	0.05%	–
KRYS	New	KRYSTAL BIOTECH INC	$2,231,000	–	150,000	–	0.05%	–
ADVM	New	ADVERUM BIOTECHNOLOGIES INC	$2,120,000	–	400,000	–	0.04%	–
FIXX	New	HOMOLOGY MEDICINES INC	$2,040,000	–	100,000	–	0.04%	–
KNSA	New	KINIKSA PHARMACEUTICALS LTD	$1,735,000	–	100,000	–	0.04%	–
SNNAQ	New	SIENNA BIOPHARMACEUTICALS IN	$1,504,000	–	99,000	–	0.03%	–
XENE	New	XENON PHARMACEUTICALS INC	$1,380,000	–	150,000	–	0.03%	–
NVLNF	New	NOVELION THERAPEUTICS INC	$944,000	–	256,400	–	0.02%	–
TOCA	New	TOCAGEN INC	$934,000	–	100,000	–	0.02%	–
	New	TRILLIUM THERAPEUTICS INC	$900,000	–	150,000	–	0.02%	–
NVAX	New	NOVAVAX INC	$670,000	–	500,000	–	0.01%	–
LIFE	New	ATYR PHARMA INC	$455,000	–	500,000	–	0.01%	–
SNDX	New	SYNDAX PHARMACEUTICALS INC	$426,000	–	60,697	–	0.01%	–
OCX	New	ONCOCYTE CORPORATION	$383,000	–	150,000	–	0.01%	–

Q4 2017

			Value		Shares		↓ Weighting
XENE	Exit	XENON PHARMACEUTICALS INC	$0	–	-150,000	–	-0.01%	–
NVAX	Exit	NOVAVAX INC	$0	–	-500,000	–	-0.01%	–
MGEN	Exit	MIRAGEN THERAPEUTICS INC	$0	–	-100,000	–	-0.02%	–
VSAR	Exit	VERSARTIS INC	$0	–	-400,000	–	-0.02%	–
KRYS	Exit	KRYSTAL BIOTECH INC	$0	–	-100,000	–	-0.02%	–
CRBP	Exit	CORBUS PHARMACEUTICALS HLDGS	$0	–	-150,000	–	-0.02%	–
OCX	Exit	ONCOCYTE CORPORATION	$0	–	-150,000	–	-0.02%	–
NK	Exit	NANTKWEST INC	$0	–	-225,000	–	-0.02%	–
ARGX	Exit	ARGENX SEsponsored adr	$0	–	-54,337	–	-0.02%	–
LIFE	Exit	ATYR PHARMA INC	$0	–	-250,000	–	-0.02%	–
DMTX	Exit	DIMENSION THERAPEUTICS INC	$0	–	-234,493	–	-0.02%	–
NLNK	Exit	NEWLINK GENETICS CORP	$0	–	-150,000	–	-0.03%	–
KURA	Exit	KURA ONCOLOGY INC	$0	–	-100,000	–	-0.03%	–
SNDX	Exit	SYNDAX PHARMACEUTICALS INC	$0	–	-152,920	–	-0.03%	–
NVLNF	Exit	NOVELION THERAPEUTICS INC	$0	–	-256,400	–	-0.03%	–
BHVN	Exit	BIOHAVEN PHARMACTL HLDG CO L	$0	–	-50,000	–	-0.03%	–
NERV	Exit	MINERVA NEUROSCIENCES INC	$0	–	-251,300	–	-0.03%	–
CLDX	Exit	CELLDEX THERAPEUTICS INC NEW	$0	–	-675,000	–	-0.03%	–
FPRX	Exit	FIVE PRIME THERAPEUTICS INC	$0	–	-50,000	–	-0.04%	–
NLNK	Exit	NEWLINK GENETICS CORPcall	$0	–	-200,000	–	-0.04%	–
ADRO	Exit	ADURO BIOTECH INC	$0	–	-200,000	–	-0.04%	–
XNCR	Exit	XENCOR INC	$0	–	-100,000	–	-0.04%	–
BLCM	Exit	BELLICUM PHARMACEUTICALS INCcall	$0	–	-200,000	–	-0.04%	–
CMRX	Exit	CHIMERIX INC	$0	–	-500,000	–	-0.04%	–
FGEN	Exit	FIBROGEN INC	$0	–	-50,000	–	-0.05%	–
RARE	Exit	ULTRAGENYX PHARMACEUTICAL IN	$0	–	-50,000	–	-0.05%	–
CALA	Exit	CALITHERA BIOSCIENCES INC	$0	–	-175,000	–	-0.05%	–
STML	Exit	STEMLINE THERAPEUTICS INC	$0	–	-250,000	–	-0.05%	–
GLYC	Exit	GLYCOMIMETICS INC	$0	–	-202,500	–	-0.05%	–
CLLS	Exit	CELLECTIS S Asponsored ads	$0	–	-100,000	–	-0.05%	–
JNCE	Exit	JOUNCE THERAPEUTICS INC	$0	–	-200,000	–	-0.05%	–
DVAX	Exit	DYNAVAX TECHNOLOGIES CORP	$0	–	-150,000	–	-0.06%	–
TSRO	Exit	TESARO INCcall	$0	–	-25,000	–	-0.06%	–
BCRX	Exit	BIOCRYST PHARMACEUTICALS	$0	–	-650,000	–	-0.06%	–
AXGT	Exit	AXOVANT SCIENCES LTD	$0	–	-500,000	–	-0.06%	–
ZFGN	Exit	ZAFGEN INC	$0	–	-1,000,000	–	-0.06%	–
VSTM	Exit	VERASTEM INC	$0	–	-750,000	–	-0.06%	–
BTX	Exit	BIOTIME INC	$0	–	-1,282,050	–	-0.06%	–
MGNX	Exit	MACROGENICS INC	$0	–	-200,000	–	-0.06%	–
CCXI	Exit	CHEMOCENTRYX INC	$0	–	-500,000	–	-0.06%	–
AKAOQ	Exit	ACHAOGEN INC	$0	–	-250,000	–	-0.07%	–
ADAP	Exit	ADAPTIMMUNE THERAPEUTICS PLCsponsored adr	$0	–	-500,000	–	-0.07%	–
NTLA	Exit	INTELLIA THERAPEUTICS INC	$0	–	-175,000	–	-0.08%	–
VTL	Exit	VITAL THERAPIES INC	$0	–	-875,000	–	-0.08%	–
ACHN	Exit	ACHILLION PHARMACEUTICALS IN	$0	–	-1,000,000	–	-0.08%	–
AXDX	Exit	ACCELERATE DIAGNOSTICS INC	$0	–	-200,000	–	-0.08%	–
ELF	Exit	E L F BEAUTY INC	$0	–	-200,000	–	-0.08%	–
TGTX	Exit	TG THERAPEUTICS INC	$0	–	-400,000	–	-0.08%	–
ANAB	Exit	ANAPTYSBIO INC	$0	–	-150,000	–	-0.09%	–
RGNX	Exit	REGENXBIO INC	$0	–	-160,000	–	-0.09%	–
SGEN	Exit	SEATTLE GENETICS INCcall	$0	–	-100,000	–	-0.09%	–
ACIU	Exit	AC IMMUNE SA	$0	–	-500,000	–	-0.10%	–
BOLD	Exit	AUDENTES THERAPEUTICS INC	$0	–	-200,000	–	-0.10%	–
ALDR	Exit	ALDER BIOPHARMACEUTICALS INC	$0	–	-500,000	–	-0.11%	–
HZNP	Exit	HORIZON PHARMA PLCcall	$0	–	-500,000	–	-0.11%	–
HZNP	Exit	HORIZON PHARMA PLC	$0	–	-500,000	–	-0.11%	–
JUNO	Exit	JUNO THERAPEUTICS INC	$0	–	-150,000	–	-0.12%	–
BLUE	Exit	BLUEBIRD BIO INCcall	$0	–	-50,000	–	-0.12%	–
PRQR	Exit	PROQR THRAPEUTICS N V	$0	–	-1,500,000	–	-0.12%	–
MDCO	Exit	MEDICINES COcall	$0	–	-200,000	–	-0.13%	–
GBT	Exit	GLOBAL BLOOD THERAPEUTICS INcall	$0	–	-250,000	–	-0.13%	–
MCRB	Exit	SERES THERAPEUTICS INC	$0	–	-550,000	–	-0.15%	–
JUNO	Exit	JUNO THERAPEUTICS INCcall	$0	–	-200,000	–	-0.16%	–
SRPT	Exit	SAREPTA THERAPEUTICS INC	$0	–	-200,000	–	-0.16%	–
GBT	Exit	GLOBAL BLOOD THERAPEUTICS IN	$0	–	-300,000	–	-0.16%	–
BMRN	Exit	BIOMARIN PHARMACEUTICAL INCcall	$0	–	-100,000	–	-0.16%	–
SAGE	Exit	SAGE THERAPEUTICS INC	$0	–	-150,000	–	-0.16%	–
CLVS	Exit	CLOVIS ONCOLOGY INC	$0	–	-115,000	–	-0.16%	–
RDUS	Exit	RADIUS HEALTH INC	$0	–	-250,000	–	-0.17%	–
TSRO	Exit	TESARO INC	$0	–	-75,000	–	-0.17%	–
ATRA	Exit	ATARA BIOTHERAPEUTICS INC	$0	–	-600,000	–	-0.17%	–
FOLD	Exit	AMICUS THERAPEUTICS INC	$0	–	-700,000	–	-0.18%	–
AGEN	Exit	AGENUS INC	$0	–	-2,500,000	–	-0.19%	–
RXDX	Exit	IGNYTA INC	$0	–	-900,000	–	-0.19%	–
MDCO	Exit	MEDICINES CO	$0	–	-300,000	–	-0.19%	–
AVXS	Exit	AVEXIS INC	$0	–	-120,000	–	-0.20%	–
ARRY	Exit	ARRAY BIOPHARMA INCcall	$0	–	-1,000,000	–	-0.21%	–
WUBA	Exit	58 COM INCcall	$0	–	-200,000	–	-0.22%	–
IRWD	Exit	IRONWOOD PHARMACEUTICALS INC	$0	–	-816,879	–	-0.22%	–
TER	Exit	TERADYNE INCcall	$0	–	-350,000	–	-0.22%	–
RDUS	Exit	RADIUS HEALTH INCcall	$0	–	-350,000	–	-0.23%	–
NKTR	Exit	NEKTAR THERAPEUTICScall	$0	–	-600,000	–	-0.25%	–
MS	Exit	MORGAN STANLEYcall	$0	–	-300,000	–	-0.25%	–
FOLD	Exit	AMICUS THERAPEUTICS INCcall	$0	–	-1,000,000	–	-0.26%	–
INCY	Exit	INCYTE CORPcall	$0	–	-150,000	–	-0.30%	–
ARRY	Exit	ARRAY BIOPHARMA INC	$0	–	-1,500,000	–	-0.32%	–
BLUE	Exit	BLUEBIRD BIO INC	$0	–	-135,000	–	-0.32%	–
BMRN	Exit	BIOMARIN PHARMACEUTICAL INC	$0	–	-200,000	–	-0.32%	–
AMGN	Exit	AMGEN INCcall	$0	–	-100,000	–	-0.32%	–
INTC	Exit	INTEL CORPcall	$0	–	-500,000	–	-0.33%	–
GILD	Exit	GILEAD SCIENCES INCcall	$0	–	-250,000	–	-0.35%	–
MET	Exit	METLIFE INCcall	$0	–	-400,000	–	-0.36%	–
C	Exit	CITIGROUP INCcall	$0	–	-300,000	–	-0.38%	–
BLK	Exit	BLACKROCK INCcall	$0	–	-50,000	–	-0.38%	–
BGNE	Exit	BEIGENE LTDsponsored adr	$0	–	-225,000	–	-0.40%	–
AAL	Exit	AMERICAN AIRLS GROUP INCcall	$0	–	-500,000	–	-0.41%	–
NBIX	Exit	NEUROCRINE BIOSCIENCES INC	$0	–	-400,000	–	-0.42%	–
XLRN	Exit	ACCELERON PHARMA INC	$0	–	-700,000	–	-0.45%	–
IBM	Exit	INTERNATIONAL BUSINESS MACHScall	$0	–	-200,000	–	-0.50%	–
ALNY	Exit	ALNYLAM PHARMACEUTICALS INC	$0	–	-250,000	–	-0.51%	–
AGIO	Exit	AGIOS PHARMACEUTICALS INC	$0	–	-450,000	–	-0.52%	–
NKTR	Exit	NEKTAR THERAPEUTICS	$0	–	-1,250,000	–	-0.52%	–
WFC	Exit	WELLS FARGO CO NEWcall	$0	–	-650,000	–	-0.62%	–
AGN	Exit	ALLERGAN PLCcall	$0	–	-200,000	–	-0.71%	–
BMY	Exit	BRISTOL MYERS SQUIBB COcall	$0	–	-650,000	–	-0.71%	–
INCY	Exit	INCYTE CORP	$0	–	-400,000	–	-0.80%	–
GS	Exit	GOLDMAN SACHS GROUP INCcall	$0	–	-200,000	–	-0.82%	–
BAC	Exit	BANK AMER CORPcall	$0	–	-9,850,000	–	-4.30%	–
LXRX	Exit	LEXICON PHARMACEUTICALS INC	$0	–	-57,517,977	–	-12.18%	–
WW	Exit	WEIGHT WATCHERS INTL INC NEW	$0	–	-29,443,300	–	-22.09%	–
BUFF	Exit	BLUE BUFFALO PET PRODS INC	$0	–	-87,460,875	–	-42.71%	–

Q3 2017

			Value		Shares		↓ Weighting
BAC	Buy	BANK AMER CORPcall	$249,599,000	+21.8%	9,850,000	+16.6%	4.30%	+20.1%
GS	Sell	GOLDMAN SACHS GROUP INCcall	$47,438,000	-85.3%	200,000	-86.2%	0.82%	-85.5%
BMY	Sell	BRISTOL MYERS SQUIBB COcall	$41,431,000	-25.6%	650,000	-35.0%	0.71%	-26.6%
AGN	New	ALLERGAN PLCcall	$40,990,000	–	200,000	–	0.71%	–
NKTR	Sell	NEKTAR THERAPEUTICS	$30,000,000	+9.6%	1,250,000	-10.7%	0.52%	+8.2%
AGIO	Sell	AGIOS PHARMACEUTICALS INC	$30,038,000	-16.6%	450,000	-35.7%	0.52%	-17.8%
ALNY	Sell	ALNYLAM PHARMACEUTICALS INC	$29,373,000	+33.9%	250,000	-9.1%	0.51%	+32.1%
NBIX	Sell	NEUROCRINE BIOSCIENCES INC	$24,512,000	-3.1%	400,000	-27.3%	0.42%	-4.5%
AAL	New	AMERICAN AIRLS GROUP INCcall	$23,745,000	–	500,000	–	0.41%	–
BGNE	Sell	BEIGENE LTDsponsored adr	$23,279,000	+29.3%	225,000	-43.8%	0.40%	+27.7%
BLK	New	BLACKROCK INCcall	$22,355,000	–	50,000	–	0.38%	–
C	Sell	CITIGROUP INCcall	$21,822,000	-34.7%	300,000	-40.0%	0.38%	-35.6%
MET	Sell	METLIFE INCcall	$20,780,000	-84.9%	400,000	-84.0%	0.36%	-85.1%
GILD	Sell	GILEAD SCIENCES INCcall	$20,255,000	-77.1%	250,000	-80.0%	0.35%	-77.4%
INTC	New	INTEL CORPcall	$19,040,000	–	500,000	–	0.33%	–
AMGN	New	AMGEN INCcall	$18,645,000	–	100,000	–	0.32%	–
BMRN	Sell	BIOMARIN PHARMACEUTICAL INC	$18,614,000	-18.0%	200,000	-20.0%	0.32%	-19.1%
BLUE	Sell	BLUEBIRD BIO INC	$18,542,000	-29.4%	135,000	-46.0%	0.32%	-30.5%
ARRY	Buy	ARRAY BIOPHARMA INC	$18,450,000	+132.0%	1,500,000	+57.9%	0.32%	+128.8%
INCY	Sell	INCYTE CORPcall	$17,511,000	-30.5%	150,000	-25.0%	0.30%	-31.4%
FOLD	Buy	AMICUS THERAPEUTICS INCcall	$15,080,000	+199.5%	1,000,000	+100.0%	0.26%	+195.5%
MS	Sell	MORGAN STANLEYcall	$14,451,000	-35.1%	300,000	-40.0%	0.25%	-36.0%
NKTR	Sell	NEKTAR THERAPEUTICScall	$14,400,000	-26.3%	600,000	-40.0%	0.25%	-27.5%
RDUS	Buy	RADIUS HEALTH INCcall	$13,493,000	+49.2%	350,000	+75.0%	0.23%	+46.8%
TER	Sell	TERADYNE INCcall	$13,052,000	-13.1%	350,000	-30.0%	0.22%	-14.1%
IRWD	Buy	IRONWOOD PHARMACEUTICALS INC	$12,882,000	+10.6%	816,879	+32.4%	0.22%	+9.4%
WUBA	New	58 COM INCcall	$12,628,000	–	200,000	–	0.22%	–
ARRY	Buy	ARRAY BIOPHARMA INCcall	$12,300,000	+193.9%	1,000,000	+100.0%	0.21%	+190.4%
AVXS	Sell	AVEXIS INC	$11,608,000	+0.9%	120,000	-14.3%	0.20%	-0.5%
MDCO	Sell	MEDICINES CO	$11,112,000	-16.5%	300,000	-14.3%	0.19%	-17.7%
AGEN	Buy	AGENUS INC	$11,025,000	+41.0%	2,500,000	+25.0%	0.19%	+38.7%
FOLD	Sell	AMICUS THERAPEUTICS INC	$10,556,000	-25.1%	700,000	-50.0%	0.18%	-26.0%
ATRA	Buy	ATARA BIOTHERAPEUTICS INC	$9,930,000	+41.9%	600,000	+20.0%	0.17%	+40.2%
TSRO	Buy	TESARO INC	$9,683,000	+38.5%	75,000	+50.0%	0.17%	+36.9%
RDUS	Buy	RADIUS HEALTH INC	$9,638,000	+42.0%	250,000	+66.7%	0.17%	+39.5%
CLVS	Buy	CLOVIS ONCOLOGY INC	$9,476,000	+304.8%	115,000	+360.0%	0.16%	+297.6%
SAGE	Buy	SAGE THERAPEUTICS INC	$9,345,000	+30.4%	150,000	+66.7%	0.16%	+28.8%
GBT	Buy	GLOBAL BLOOD THERAPEUTICS IN	$9,315,000	+240.6%	300,000	+200.0%	0.16%	+233.3%
BMRN	Sell	BIOMARIN PHARMACEUTICAL INCcall	$9,307,000	-31.7%	100,000	-33.3%	0.16%	-32.8%
SRPT	Buy	SAREPTA THERAPEUTICS INC	$9,072,000	+79.4%	200,000	+33.3%	0.16%	+77.3%
JUNO	Buy	JUNO THERAPEUTICS INCcall	$8,972,000	+500.1%	200,000	+300.0%	0.16%	+496.2%
MCRB	Sell	SERES THERAPEUTICS INC	$8,822,000	+30.1%	550,000	-8.3%	0.15%	+28.8%
PRQR	Buy	PROQR THRAPEUTICS N V	$7,275,000	+179.8%	1,500,000	+200.0%	0.12%	+177.8%
JUNO	Sell	JUNO THERAPEUTICS INC	$6,729,000	+12.6%	150,000	-25.0%	0.12%	+11.5%
HZNP	Sell	HORIZON PHARMA PLC	$6,340,000	-29.7%	500,000	-34.2%	0.11%	-31.0%
ALDR	Buy	ALDER BIOPHARMACEUTICALS INC	$6,125,000	+78.3%	500,000	+66.7%	0.11%	+76.7%
BOLD	New	AUDENTES THERAPEUTICS INC	$5,602,000	–	200,000	–	0.10%	–
ANAB	Sell	ANAPTYSBIO INC	$5,243,000	-12.4%	150,000	-40.0%	0.09%	-14.3%
TGTX	Sell	TG THERAPEUTICS INC	$4,740,000	-5.7%	400,000	-20.0%	0.08%	-6.8%
ELF	Sell	E L F BEAUTY INC	$4,510,000	-33.7%	200,000	-20.0%	0.08%	-34.5%
ACHN	New	ACHILLION PHARMACEUTICALS IN	$4,490,000	–	1,000,000	–	0.08%	–
NTLA	Sell	INTELLIA THERAPEUTICS INC	$4,349,000	+8.7%	175,000	-30.0%	0.08%	+7.1%
ADAP	Buy	ADAPTIMMUNE THERAPEUTICS PLCsponsored adr	$4,095,000	+204.0%	500,000	+66.7%	0.07%	+195.8%
AKAOQ	Buy	ACHAOGEN INC	$3,988,000	-8.2%	250,000	+25.0%	0.07%	-9.2%
MGNX	Sell	MACROGENICS INC	$3,696,000	-29.6%	200,000	-33.3%	0.06%	-30.4%
VSTM	Buy	VERASTEM INC	$3,525,000	+223.4%	750,000	+50.0%	0.06%	+221.1%
BCRX	Sell	BIOCRYST PHARMACEUTICALS	$3,406,000	-27.9%	650,000	-23.5%	0.06%	-28.9%
AXGT	Buy	AXOVANT SCIENCES LTD	$3,440,000	-15.2%	500,000	+185.7%	0.06%	-16.9%
DVAX	New	DYNAVAX TECHNOLOGIES CORP	$3,225,000	–	150,000	–	0.06%	–
TSRO	Sell	TESARO INCcall	$3,228,000	-90.2%	25,000	-89.4%	0.06%	-90.2%
JNCE	Sell	JOUNCE THERAPEUTICS INC	$3,116,000	-11.2%	200,000	-20.0%	0.05%	-11.5%
CALA	Sell	CALITHERA BIOSCIENCES INC	$2,756,000	-7.2%	175,000	-12.5%	0.05%	-9.6%
FGEN	New	FIBROGEN INC	$2,690,000	–	50,000	–	0.05%	–
BLCM	New	BELLICUM PHARMACEUTICALS INCcall	$2,310,000	–	200,000	–	0.04%	–
XNCR	New	XENCOR INC	$2,292,000	–	100,000	–	0.04%	–
ADRO	Buy	ADURO BIOTECH INC	$2,130,000	+86.8%	200,000	+100.0%	0.04%	+85.0%
NLNK	New	NEWLINK GENETICS CORPcall	$2,036,000	–	200,000	–	0.04%	–
FPRX	Sell	FIVE PRIME THERAPEUTICS INC	$2,046,000	-54.7%	50,000	-66.7%	0.04%	-55.7%
BHVN	New	BIOHAVEN PHARMACTL HLDG CO L	$1,869,000	–	50,000	–	0.03%	–
SNDX	Sell	SYNDAX PHARMACEUTICALS INC	$1,789,000	-57.3%	152,920	-49.0%	0.03%	-57.5%
KURA	New	KURA ONCOLOGY INC	$1,495,000	–	100,000	–	0.03%	–
NLNK	New	NEWLINK GENETICS CORP	$1,527,000	–	150,000	–	0.03%	–
LIFE	New	ATYR PHARMA INC	$1,263,000	–	250,000	–	0.02%	–
ARGX	New	ARGENX SEsponsored adr	$1,229,000	–	54,337	–	0.02%	–
CRBP	Sell	CORBUS PHARMACEUTICALS HLDGS	$1,073,000	-31.9%	150,000	-40.0%	0.02%	-35.7%
VSAR	Buy	VERSARTIS INC	$980,000	-84.0%	400,000	+14.3%	0.02%	-84.1%
KRYS	New	KRYSTAL BIOTECH INC	$997,000	–	100,000	–	0.02%	–
MGEN	New	MIRAGEN THERAPEUTICS INC	$915,000	–	100,000	–	0.02%	–
	Exit	NEURODERM LTD	$0	–	-25,000	–	-0.01%	–
AIMT	Exit	AIMMUNE THERAPEUTICS INC	$0	–	-100,000	–	-0.04%	–
ALXN	Exit	ALEXION PHARMACEUTICALS INCcall	$0	–	-20,900	–	-0.04%	–
FCX	Exit	FREEPORT-MCMORAN INCcl b	$0	–	-250,000	–	-0.05%	–
ONCE	Exit	SPARK THERAPEUTICS INC	$0	–	-50,000	–	-0.05%	–
SRPT	Exit	SAREPTA THERAPEUTICS INCcall	$0	–	-100,000	–	-0.06%	–
SGEN	Exit	SEATTLE GENETICS INC.	$0	–	-75,000	–	-0.07%	–
AGIO	Exit	AGIOS PHARMACEUTICALS INCcall	$0	–	-100,000	–	-0.09%	–
MET	Exit	METLIFE INC	$0	–	-100,000	–	-0.10%	–
IONS	Exit	IONIS PHARMACEUTICALS INC	$0	–	-135,000	–	-0.12%	–
ZTO	Exit	ZTO EXPRESS CAYMAN INCsponsored adr	$0	–	-500,000	–	-0.12%	–
ATH	Exit	ATHENE HLDG LTDcl a	$0	–	-200,000	–	-0.17%	–
KITE	Exit	KITE PHARMA INC	$0	–	-100,000	–	-0.18%	–
ALXN	Exit	ALEXION PHARMACEUTICALS INC	$0	–	-100,000	–	-0.21%	–
GS	Exit	GOLDMAN SACHS GROUP INC	$0	–	-100,000	–	-0.39%	–
ABBV	Exit	ABBVIE INCcall	$0	–	-500,000	–	-0.63%	–
MSFT	Exit	MICROSOFT CORPcall	$0	–	-1,000,000	–	-1.20%	–

Q2 2017

			Value		Shares		↓ Weighting
BUFF	New	BLUE BUFFALO PET PRODS INC	$1,994,983,000	–	87,460,875	–	34.85%	–
WW	New	WEIGHT WATCHERS INTL INC NEW	$983,995,000	–	29,443,300	–	17.19%	–
LXRX	New	LEXICON PHARMACEUTICALS INC	$946,170,000	–	57,517,977	–	16.53%	–
GS	New	GOLDMAN SACHS GROUP INCcall	$321,755,000	–	1,450,000	–	5.62%	–
BAC	New	BANK AMER CORPcall	$204,997,000	–	8,450,000	–	3.58%	–
MET	New	METLIFE INCcall	$137,350,000	–	2,500,000	–	2.40%	–
GILD	New	GILEAD SCIENCES INCcall	$88,475,000	–	1,250,000	–	1.55%	–
MSFT	New	MICROSOFT CORPcall	$68,930,000	–	1,000,000	–	1.20%	–
BMY	New	BRISTOL MYERS SQUIBB COcall	$55,720,000	–	1,000,000	–	0.97%	–
INCY	New	INCYTE CORP	$50,364,000	–	400,000	–	0.88%	–
ABBV	New	ABBVIE INCcall	$36,255,000	–	500,000	–	0.63%	–
WFC	New	WELLS FARGO & CO NEWcall	$36,017,000	–	650,000	–	0.63%	–
AGIO	New	AGIOS PHARMACEUTICALS INC	$36,015,000	–	700,000	–	0.63%	–
C	New	CITIGROUP INCcall	$33,440,000	–	500,000	–	0.58%	–
TSRO	New	TESARO INCcall	$32,867,000	–	235,000	–	0.57%	–
IBM	New	INTERNATIONAL BUSINESS MACHScall	$30,766,000	–	200,000	–	0.54%	–
NKTR	New	NEKTAR THERAPEUTICS	$27,370,000	–	1,400,000	–	0.48%	–
BLUE	New	BLUEBIRD BIO INC	$26,263,000	–	250,000	–	0.46%	–
NBIX	New	NEUROCRINE BIOSCIENCES INC	$25,300,000	–	550,000	–	0.44%	–
INCY	New	INCYTE CORPcall	$25,182,000	–	200,000	–	0.44%	–
BMRN	New	BIOMARIN PHARMACEUTICAL INC	$22,705,000	–	250,000	–	0.40%	–
MS	New	MORGAN STANLEYcall	$22,280,000	–	500,000	–	0.39%	–
GS	New	GOLDMAN SACHS GROUP INC	$22,190,000	–	100,000	–	0.39%	–
ALNY	New	ALNYLAM PHARMACEUTICALS INC	$21,934,000	–	275,000	–	0.38%	–
XLRN	New	ACCELERON PHARMA INC	$21,273,000	–	700,000	–	0.37%	–
NKTR	New	NEKTAR THERAPEUTICScall	$19,550,000	–	1,000,000	–	0.34%	–
BGNE	New	BEIGENE LTDsponsored adr	$18,000,000	–	400,000	–	0.31%	–
TER	New	TERADYNE INCcall	$15,015,000	–	500,000	–	0.26%	–
FOLD	New	AMICUS THERAPEUTICS INC	$14,098,000	–	1,400,000	–	0.25%	–
BMRN	New	BIOMARIN PHARMACEUTICAL INCcall	$13,623,000	–	150,000	–	0.24%	–
MDCO	New	MEDICINES CO	$13,304,000	–	350,000	–	0.23%	–
ALXN	New	ALEXION PHARMACEUTICALS INC	$12,167,000	–	100,000	–	0.21%	–
IRWD	New	IRONWOOD PHARMACEUTICALS INC	$11,647,000	–	616,879	–	0.20%	–
AVXS	New	AVEXIS INC	$11,502,000	–	140,000	–	0.20%	–
KITE	New	KITE PHARMA INC	$10,367,000	–	100,000	–	0.18%	–
ATH	New	ATHENE HLDG LTDcl a	$9,922,000	–	200,000	–	0.17%	–
RXDX	New	IGNYTA INC	$9,315,000	–	900,000	–	0.16%	–
HZNP	New	HORIZON PHARMA PLC	$9,021,000	–	760,000	–	0.16%	–
RDUS	New	RADIUS HEALTH INCcall	$9,046,000	–	200,000	–	0.16%	–
ARRY	New	ARRAY BIOPHARMA INC	$7,952,000	–	950,000	–	0.14%	–
AGEN	New	AGENUS INC	$7,820,000	–	2,000,000	–	0.14%	–
MDCO	New	MEDICINES COcall	$7,602,000	–	200,000	–	0.13%	–
SAGE	New	SAGE THERAPEUTICS INC	$7,168,000	–	90,000	–	0.12%	–
ZTO	New	ZTO EXPRESS CAYMAN INCsponsored adr	$6,980,000	–	500,000	–	0.12%	–
TSRO	New	TESARO INC	$6,993,000	–	50,000	–	0.12%	–
ATRA	New	ATARA BIOTHERAPEUTICS INC	$7,000,000	–	500,000	–	0.12%	–
IONS	New	IONIS PHARMACEUTICALS INC	$6,867,000	–	135,000	–	0.12%	–
GBT	New	GLOBAL BLOOD THERAPEUTICS INcall	$6,838,000	–	250,000	–	0.12%	–
ELF	New	E L F BEAUTY INC	$6,803,000	–	250,000	–	0.12%	–
RDUS	New	RADIUS HEALTH INC	$6,785,000	–	150,000	–	0.12%	–
MCRB	New	SERES THERAPEUTICS INC	$6,780,000	–	600,000	–	0.12%	–
VSAR	New	VERSARTIS INC	$6,108,000	–	350,000	–	0.11%	–
ANAB	New	ANAPTYSBIO INC	$5,983,000	–	250,000	–	0.10%	–
HZNP	New	HORIZON PHARMA PLCcall	$5,935,000	–	500,000	–	0.10%	–
JUNO	New	JUNO THERAPEUTICS INC	$5,978,000	–	200,000	–	0.10%	–
AXDX	New	ACCELERATE DIAGNOSTICS INC	$5,470,000	–	200,000	–	0.10%	–
MET	New	METLIFE INC	$5,494,000	–	100,000	–	0.10%	–
MGNX	New	MACROGENICS INC	$5,253,000	–	300,000	–	0.09%	–
BLUE	New	BLUEBIRD BIO INCcall	$5,253,000	–	50,000	–	0.09%	–
SGEN	New	SEATTLE GENETICS INC.call	$5,174,000	–	100,000	–	0.09%	–
AGIO	New	AGIOS PHARMACEUTICALS INCcall	$5,145,000	–	100,000	–	0.09%	–
FOLD	New	AMICUS THERAPEUTICS INCcall	$5,035,000	–	500,000	–	0.09%	–
TGTX	New	TG THERAPEUTICS INC	$5,025,000	–	500,000	–	0.09%	–
SRPT	New	SAREPTA THERAPEUTICS INC	$5,057,000	–	150,000	–	0.09%	–
BCRX	New	BIOCRYST PHARMACEUTICALS	$4,726,000	–	850,000	–	0.08%	–
CCXI	New	CHEMOCENTRYX INC	$4,680,000	–	500,000	–	0.08%	–
FPRX	New	FIVE PRIME THERAPEUTICS INC	$4,517,000	–	150,000	–	0.08%	–
ACIU	New	AC IMMUNE SA	$4,400,000	–	500,000	–	0.08%	–
AKAOQ	New	ACHAOGEN INC	$4,346,000	–	200,000	–	0.08%	–
ARRY	New	ARRAY BIOPHARMA INCcall	$4,185,000	–	500,000	–	0.07%	–
SNDX	New	SYNDAX PHARMACEUTICALS INC	$4,191,000	–	300,000	–	0.07%	–
AXGT	New	AXOVANT SCIENCES LTD	$4,058,000	–	175,000	–	0.07%	–
BTX	New	BIOTIME INC	$4,038,000	–	1,282,050	–	0.07%	–
NTLA	New	INTELLIA THERAPEUTICS INC	$4,000,000	–	250,000	–	0.07%	–
SGEN	New	SEATTLE GENETICS INC.	$3,881,000	–	75,000	–	0.07%	–
ZFGN	New	ZAFGEN INC	$3,510,000	–	1,000,000	–	0.06%	–
JNCE	New	JOUNCE THERAPEUTICS INC	$3,508,000	–	250,000	–	0.06%	–
ALDR	New	ALDER BIOPHARMACEUTICALS INC	$3,435,000	–	300,000	–	0.06%	–
SRPT	New	SAREPTA THERAPEUTICS INCcall	$3,371,000	–	100,000	–	0.06%	–
RGNX	New	REGENXBIO INC	$3,160,000	–	160,000	–	0.06%	–
RARE	New	ULTRAGENYX PHARMACEUTICAL IN	$3,106,000	–	50,000	–	0.05%	–
ONCE	New	SPARK THERAPEUTICS INC	$2,987,000	–	50,000	–	0.05%	–
FCX	New	FREEPORT-MCMORAN INCcl b	$3,003,000	–	250,000	–	0.05%	–
CALA	New	CALITHERA BIOSCIENCES INC	$2,970,000	–	200,000	–	0.05%	–
CMRX	New	CHIMERIX INC	$2,725,000	–	500,000	–	0.05%	–
GBT	New	GLOBAL BLOOD THERAPEUTICS IN	$2,735,000	–	100,000	–	0.05%	–
PRQR	New	PROQR THRAPEUTICS N V	$2,600,000	–	500,000	–	0.04%	–
CLLS	New	CELLECTIS S Asponsored ads	$2,582,000	–	100,000	–	0.04%	–
ALXN	New	ALEXION PHARMACEUTICALS INCcall	$2,543,000	–	20,900	–	0.04%	–
VTL	New	VITAL THERAPIES INC	$2,538,000	–	875,000	–	0.04%	–
NVLNF	New	NOVELION THERAPEUTICS INC	$2,367,000	–	256,400	–	0.04%	–
CLVS	New	CLOVIS ONCOLOGY INC	$2,341,000	–	25,000	–	0.04%	–
STML	New	STEMLINE THERAPEUTICS INC	$2,300,000	–	250,000	–	0.04%	–
GLYC	New	GLYCOMIMETICS INC	$2,260,000	–	202,500	–	0.04%	–
NERV	New	MINERVA NEUROSCIENCES INC	$2,224,000	–	251,300	–	0.04%	–
AIMT	New	AIMMUNE THERAPEUTICS INC	$2,056,000	–	100,000	–	0.04%	–
NK	New	NANTKWEST INC	$1,708,000	–	225,000	–	0.03%	–
CLDX	New	CELLDEX THERAPEUTICS INC NEW	$1,667,000	–	675,000	–	0.03%	–
CRBP	New	CORBUS PHARMACEUTICALS HLDGS	$1,575,000	–	250,000	–	0.03%	–
JUNO	New	JUNO THERAPEUTICS INCcall	$1,495,000	–	50,000	–	0.03%	–
ADAP	New	ADAPTIMMUNE THERAPEUTICS PLCsponsored adr	$1,347,000	–	300,000	–	0.02%	–
ADRO	New	ADURO BIOTECH INC	$1,140,000	–	100,000	–	0.02%	–
VSTM	New	VERASTEM INC	$1,090,000	–	500,000	–	0.02%	–
OCX	New	ONCOCYTE CORPORATION	$780,000	–	150,000	–	0.01%	–
	New	NEURODERM LTD	$748,000	–	25,000	–	0.01%	–
NVAX	New	NOVAVAX INC	$575,000	–	500,000	–	0.01%	–
XENE	New	XENON PHARMACEUTICALS INC	$473,000	–	150,000	–	0.01%	–
DMTX	New	DIMENSION THERAPEUTICS INC	$340,000	–	234,493	–	0.01%	–

Q4 2016

			Value		Shares		↓ Weighting
OCX	Exit	ONCOCYTE CORPORATION	$0	–	-64,102	–	-0.01%	–
NVAX	Exit	NOVAVAX INC	$0	–	-500,000	–	-0.02%	–
ADRO	Exit	ADURO BIOTECH INC	$0	–	-100,000	–	-0.02%	–
OPHT	Exit	OPHTHOTECH CORP	$0	–	-30,000	–	-0.03%	–
ADAP	Exit	ADAPTIMMUNE THERAPEUTICS PLCsponds adr	$0	–	-200,000	–	-0.03%	–
NK	Exit	NANTKWEST INC	$0	–	-225,000	–	-0.04%	–
DOFSQ	Exit	DIAMOND OFFSHORE DRILLING IN	$0	–	-100,000	–	-0.04%	–
DMTX	Exit	DIMENSION THERAPEUTICS INC	$0	–	-234,493	–	-0.04%	–
LOXO	Exit	LOXO ONCOLOGY INC	$0	–	-75,000	–	-0.04%	–
CLCD	Exit	COLUCID PHARMACEUTICALS INC	$0	–	-55,575	–	-0.04%	–
GBT	Exit	GLOBAL BLOOD THERAPEUTICS IN	$0	–	-100,000	–	-0.05%	–
ACIU	Exit	AC IMMUNE SA	$0	–	-150,000	–	-0.05%	–
RDUS	Exit	RADIUS HEALTH INC	$0	–	-50,000	–	-0.05%	–
CLDX	Exit	CELLDEX THERAPEUTICS INC NEW	$0	–	-675,000	–	-0.05%	–
CMRX	Exit	CHIMERIX INC	$0	–	-500,000	–	-0.06%	–
NERV	Exit	MINERVA NEUROSCIENCES INC	$0	–	-200,000	–	-0.06%	–
ONCE	Exit	SPARK THERAPEUTICS INC	$0	–	-50,000	–	-0.06%	–
AEGR	Exit	AEGERION PHARMACEUTICALS INC	$0	–	-1,000,000	–	-0.06%	–
JUNO	Exit	JUNO THERAPEUTICS INCcall	$0	–	-100,000	–	-0.06%	–
BLUE	Exit	BLUEBIRD BIO INCcall	$0	–	-50,000	–	-0.07%	–
IRWD	Exit	IRONWOOD PHARMACEUTICALS INC	$0	–	-216,879	–	-0.07%	–
NTLA	Exit	INTELLIA THERAPEUTICS INC	$0	–	-205,000	–	-0.07%	–
AXGT	Exit	AXOVANT SCIENCES LTD	$0	–	-250,000	–	-0.07%	–
VVV	Exit	VALVOLINE INC	$0	–	-150,000	–	-0.07%	–
RARE	Exit	ULTRAGENYX PHARMACEUTICAL INcall	$0	–	-50,000	–	-0.07%	–
RARE	Exit	ULTRAGENYX PHARMACEUTICAL IN	$0	–	-50,000	–	-0.07%	–
AGEN	Exit	AGENUS INCcall	$0	–	-500,000	–	-0.07%	–
CLLS	Exit	CELLECTIS S Asponsored ads	$0	–	-150,000	–	-0.07%	–
RGNX	Exit	REGENXBIO INC	$0	–	-300,000	–	-0.08%	–
ELF	Exit	E L F BEAUTY INC	$0	–	-150,000	–	-0.08%	–
MGNX	Exit	MACROGENICS INC	$0	–	-150,000	–	-0.09%	–
CTRP	Exit	CTRIP COM INTL LTD	$0	–	-100,000	–	-0.09%	–
ATRA	Exit	ATARA BIOTHERAPEUTICS INC	$0	–	-225,000	–	-0.10%	–
FOLD	Exit	AMICUS THERAPEUTICS INCcall	$0	–	-650,000	–	-0.10%	–
CEMP	Exit	CEMPRA INC	$0	–	-200,000	–	-0.10%	–
NTB	Exit	BANK OF NT BUTTERFIELD&SON L	$0	–	-200,000	–	-0.10%	–
SPNC	Exit	SPECTRANETICS CORP	$0	–	-200,000	–	-0.10%	–
BTX	Exit	BIOTIME INC	$0	–	-1,282,050	–	-0.10%	–
NBIX	Exit	NEUROCRINE BIOSCIENCES INC	$0	–	-100,000	–	-0.10%	–
USFD	Exit	US FOODS HLDG CORP	$0	–	-225,000	–	-0.10%	–
RXDX	Exit	IGNYTA INC	$0	–	-850,000	–	-0.11%	–
JUNO	Exit	JUNO THERAPEUTICS INC	$0	–	-200,000	–	-0.12%	–
SRPT	Exit	SAREPTA THERAPEUTICS INCcall	$0	–	-100,000	–	-0.12%	–
MCRB	Exit	SERES THERAPEUTICS INC	$0	–	-500,000	–	-0.12%	–
XLRN	Exit	ACCELERON PHARMA INC	$0	–	-175,000	–	-0.12%	–
HZNP	Exit	HORIZON PHARMA PLC	$0	–	-350,000	–	-0.13%	–
JD	Exit	JD COM INCcall	$0	–	-250,000	–	-0.13%	–
ALNY	Exit	ALNYLAM PHARMACEUTICALS INCcall	$0	–	-100,000	–	-0.13%	–
AGEN	Exit	AGENUS INC	$0	–	-1,000,000	–	-0.14%	–
CCXI	Exit	CHEMOCENTRYX INC	$0	–	-1,200,000	–	-0.14%	–
IONS	Exit	IONIS PHARMACEUTICALS INCcall	$0	–	-200,000	–	-0.14%	–
AMAG	Exit	AMAG PHARMACEUTICALS INC	$0	–	-300,000	–	-0.15%	–
MET	Exit	METLIFE INC	$0	–	-175,000	–	-0.15%	–
AVXS	Exit	AVEXIS INC	$0	–	-200,000	–	-0.16%	–
SAGE	Exit	SAGE THERAPEUTICS INC	$0	–	-200,000	–	-0.18%	–
INCY	Exit	INCYTE CORPcall	$0	–	-100,000	–	-0.19%	–
TSLA	Exit	TESLA MTRS INC	$0	–	-50,000	–	-0.20%	–
3106PS	Exit	DELPHI AUTOMOTIVE PLC	$0	–	-150,000	–	-0.21%	–
MS	Exit	MORGAN STANLEY	$0	–	-350,000	–	-0.22%	–
SRPT	Exit	SAREPTA THERAPEUTICS INC	$0	–	-200,000	–	-0.24%	–
FOLD	Exit	AMICUS THERAPEUTICS INC	$0	–	-1,900,000	–	-0.28%	–
WFC	Exit	WELLS FARGO & CO NEWcall	$0	–	-350,000	–	-0.31%	–
BAC	Exit	BANK AMER CORP	$0	–	-1,000,000	–	-0.31%	–
IBM	Exit	INTERNATIONAL BUSINESS MACHScall	$0	–	-100,000	–	-0.32%	–
JPM	Exit	JPMORGAN CHASE & COcall	$0	–	-250,000	–	-0.33%	–
PFE	Exit	PFIZER INCcall	$0	–	-500,000	–	-0.34%	–
NKTR	Exit	NEKTAR THERAPEUTICS	$0	–	-1,000,000	–	-0.34%	–
KITE	Exit	KITE PHARMA INC	$0	–	-315,000	–	-0.35%	–
AGIO	Exit	AGIOS PHARMACEUTICALS INC	$0	–	-400,000	–	-0.42%	–
ARRY	Exit	ARRAY BIOPHARMA INC	$0	–	-3,500,000	–	-0.47%	–
BLUE	Exit	BLUEBIRD BIO INC	$0	–	-385,000	–	-0.52%	–
AGIO	Exit	AGIOS PHARMACEUTICALS INCcall	$0	–	-500,000	–	-0.52%	–
BMRN	Exit	BIOMARIN PHARMACEUTICAL INC	$0	–	-300,000	–	-0.55%	–
ALXN	Exit	ALEXION PHARMACEUTICALS INCcall	$0	–	-250,000	–	-0.61%	–
BABA	Exit	ALIBABA GROUP HLDG LTDsponsored ads	$0	–	-300,000	–	-0.63%	–
CMG	Exit	CHIPOTLE MEXICAN GRILL INCcall	$0	–	-75,000	–	-0.63%	–
GOOGL	Exit	ALPHABET INCcall	$0	–	-40,000	–	-0.64%	–
GS	Exit	GOLDMAN SACHS GROUP INC	$0	–	-200,000	–	-0.64%	–
MET	Exit	METLIFE INCcall	$0	–	-750,000	–	-0.66%	–
WMT	Exit	WAL-MART STORES INCcall	$0	–	-500,000	–	-0.71%	–
FXI	Exit	ISHARES TRcall	$0	–	-1,000,000	–	-0.75%	–
REGN	Exit	REGENERON PHARMACEUTICALScall	$0	–	-100,000	–	-0.80%	–
ALNY	Exit	ALNYLAM PHARMACEUTICALS INC	$0	–	-600,000	–	-0.80%	–
BMY	Exit	BRISTOL MYERS SQUIBB COcall	$0	–	-800,000	–	-0.85%	–
BIIB	Exit	BIOGEN INCcall	$0	–	-150,000	–	-0.93%	–
INCY	Exit	INCYTE CORP	$0	–	-600,000	–	-1.12%	–
CELG	Exit	CELGENE CORPcall	$0	–	-700,000	–	-1.45%	–
BAC	Exit	BANK AMER CORPcall	$0	–	-5,000,000	–	-1.55%	–
WW	Exit	WEIGHT WATCHERS INTL INC NEW	$0	–	-29,443,300	–	-6.02%	–
GS	Exit	GOLDMAN SACHS GROUP INCcall	$0	–	-2,750,000	–	-8.78%	–
LXRX	Exit	LEXICON PHARMACEUTICALS INC	$0	–	-57,517,977	–	-20.58%	–
BUFF	Exit	BLUE BUFFALO PET PRODS INC	$0	–	-87,460,875	–	-41.14%	–

Q3 2016

			Value		Shares		↓ Weighting
BUFF	Sell	BLUE BUFFALO PET PRODS INC	$2,078,070,000	-22.6%	87,460,875	-23.9%	41.14%	-25.7%
GS	Buy	GOLDMAN SACHS GROUP INCcall	$443,493,000	+138.8%	2,750,000	+120.0%	8.78%	+129.0%
CELG	Buy	CELGENE CORPcall	$73,171,000	+270.9%	700,000	+250.0%	1.45%	+256.0%
INCY	Sell	INCYTE CORP	$56,574,000	+13.2%	600,000	-4.0%	1.12%	+8.5%
BMY	New	BRISTOL MYERS SQUIBB COcall	$43,136,000	–	800,000	–	0.85%	–
ALNY	Sell	ALNYLAM PHARMACEUTICALS INC	$40,668,000	+3.2%	600,000	-15.5%	0.80%	-1.0%
REGN	Sell	REGENERON PHARMACEUTICALScall	$40,202,000	-4.1%	100,000	-16.7%	0.80%	-8.0%
FXI	New	ISHARES TRcall	$38,010,000	–	1,000,000	–	0.75%	–
MET	Buy	METLIFE INCcall	$33,323,000	+67.3%	750,000	+50.0%	0.66%	+60.6%
CMG	New	CHIPOTLE MEXICAN GRILL INCcall	$31,763,000	–	75,000	–	0.63%	–
BABA	Sell	ALIBABA GROUP HLDG LTDsponsored ads	$31,737,000	-0.2%	300,000	-25.0%	0.63%	-4.4%
ALXN	New	ALEXION PHARMACEUTICALS INCcall	$30,635,000	–	250,000	–	0.61%	–
BMRN	Sell	BIOMARIN PHARMACEUTICAL INC	$27,756,000	+1.9%	300,000	-14.3%	0.55%	-2.1%
AGIO	New	AGIOS PHARMACEUTICALS INCcall	$26,410,000	–	500,000	–	0.52%	–
BLUE	Sell	BLUEBIRD BIO INC	$26,095,000	+34.0%	385,000	-14.4%	0.52%	+28.6%
ARRY	Sell	ARRAY BIOPHARMA INC	$23,625,000	+71.5%	3,500,000	-9.6%	0.47%	+64.8%
AGIO	Buy	AGIOS PHARMACEUTICALS INC	$21,128,000	+34.5%	400,000	+6.7%	0.42%	+29.0%
KITE	Sell	KITE PHARMA INC	$17,596,000	+8.3%	315,000	-3.1%	0.35%	+3.9%
NKTR	Sell	NEKTAR THERAPEUTICS	$17,180,000	-13.8%	1,000,000	-28.6%	0.34%	-17.3%
PFE	New	PFIZER INCcall	$16,935,000	–	500,000	–	0.34%	–
BAC	Sell	BANK AMER CORP	$15,650,000	+7.2%	1,000,000	-9.1%	0.31%	+3.0%
WFC	New	WELLS FARGO & CO NEWcall	$15,498,000	–	350,000	–	0.31%	–
FOLD	Buy	AMICUS THERAPEUTICS INC	$14,060,000	+106.0%	1,900,000	+52.0%	0.28%	+97.2%
SRPT	New	SAREPTA THERAPEUTICS INC	$12,282,000	–	200,000	–	0.24%	–
MS	Sell	MORGAN STANLEY	$11,221,000	+8.0%	350,000	-12.5%	0.22%	+3.3%
3106PS	Sell	DELPHI AUTOMOTIVE PLC	$10,698,000	-37.9%	150,000	-45.5%	0.21%	-40.3%
TSLA	Sell	TESLA MTRS INC	$10,202,000	-35.9%	50,000	-33.3%	0.20%	-38.6%
INCY	New	INCYTE CORPcall	$9,429,000	–	100,000	–	0.19%	–
SAGE	New	SAGE THERAPEUTICS INC	$9,210,000	–	200,000	–	0.18%	–
AVXS	Buy	AVEXIS INC	$8,242,000	+33.9%	200,000	+23.5%	0.16%	+28.3%
MET	Sell	METLIFE INC	$7,775,000	-21.9%	175,000	-30.0%	0.15%	-25.2%
AMAG	New	AMAG PHARMACEUTICALS INC	$7,353,000	–	300,000	–	0.15%	–
IONS	New	IONIS PHARMACEUTICALS INCcall	$7,328,000	–	200,000	–	0.14%	–
CCXI	Buy	CHEMOCENTRYX INC	$7,248,000	+79.4%	1,200,000	+33.3%	0.14%	+73.5%
ALNY	Sell	ALNYLAM PHARMACEUTICALS INCcall	$6,778,000	-59.3%	100,000	-66.7%	0.13%	-61.0%
XLRN	Buy	ACCELERON PHARMA INC	$6,333,000	+86.4%	175,000	+75.0%	0.12%	+78.6%
MCRB	Buy	SERES THERAPEUTICS INC	$6,145,000	-31.8%	500,000	+61.3%	0.12%	-34.4%
RXDX	Buy	IGNYTA INC	$5,347,000	+31.5%	850,000	+13.3%	0.11%	+26.2%
USFD	Sell	US FOODS HLDG CORP	$5,312,000	-56.2%	225,000	-55.0%	0.10%	-58.0%
NBIX	Buy	NEUROCRINE BIOSCIENCES INC	$5,064,000	+17.3%	100,000	+5.3%	0.10%	+12.4%
SPNC	Sell	SPECTRANETICS CORP	$5,018,000	-23.4%	200,000	-42.9%	0.10%	-26.7%
NTB	New	BANK OF NT BUTTERFIELD&SON L	$4,952,000	–	200,000	–	0.10%	–
CEMP	Buy	CEMPRA INC	$4,840,000	+193.5%	200,000	+100.0%	0.10%	+182.4%
FOLD	New	AMICUS THERAPEUTICS INCcall	$4,810,000	–	650,000	–	0.10%	–
ATRA	New	ATARA BIOTHERAPEUTICS INC	$4,813,000	–	225,000	–	0.10%	–
CTRP	New	CTRIP COM INTL LTD	$4,657,000	–	100,000	–	0.09%	–
MGNX	New	MACROGENICS INC	$4,487,000	–	150,000	–	0.09%	–
ELF	New	E L F BEAUTY INC	$4,218,000	–	150,000	–	0.08%	–
RGNX	Buy	REGENXBIO INC	$4,203,000	+162.7%	300,000	+50.0%	0.08%	+151.5%
CLLS	Sell	CELLECTIS S Asponsored ads	$3,612,000	-35.3%	150,000	-28.6%	0.07%	-37.4%
RARE	New	ULTRAGENYX PHARMACEUTICAL INcall	$3,547,000	–	50,000	–	0.07%	–
VVV	New	VALVOLINE INC	$3,524,000	–	150,000	–	0.07%	–
RARE	Sell	ULTRAGENYX PHARMACEUTICAL IN	$3,547,000	-3.3%	50,000	-33.3%	0.07%	-7.9%
AXGT	New	AXOVANT SCIENCES LTD	$3,500,000	–	250,000	–	0.07%	–
NTLA	Sell	INTELLIA THERAPEUTICS INC	$3,489,000	-27.4%	205,000	-8.9%	0.07%	-30.3%
BLUE	Sell	BLUEBIRD BIO INCcall	$3,389,000	-21.7%	50,000	-50.0%	0.07%	-24.7%
JUNO	Buy	JUNO THERAPEUTICS INCcall	$3,001,000	+56.1%	100,000	+100.0%	0.06%	+47.5%
NERV	New	MINERVA NEUROSCIENCES INC	$2,823,000	–	200,000	–	0.06%	–
CMRX	New	CHIMERIX INC	$2,770,000	–	500,000	–	0.06%	–
RDUS	Sell	RADIUS HEALTH INC	$2,705,000	-26.4%	50,000	-50.0%	0.05%	-28.9%
ACIU	New	AC IMMUNE SA	$2,471,000	–	150,000	–	0.05%	–
GBT	Sell	GLOBAL BLOOD THERAPEUTICS IN	$2,305,000	+11.1%	100,000	-20.0%	0.05%	+7.0%
CLCD	Buy	COLUCID PHARMACEUTICALS INC	$2,121,000	+4510.9%	55,575	+896.9%	0.04%	+4100.0%
LOXO	New	LOXO ONCOLOGY INC	$1,964,000	–	75,000	–	0.04%	–
DMTX	Sell	DIMENSION THERAPEUTICS INC	$1,874,000	+13.6%	234,493	-14.7%	0.04%	+8.8%
DOFSQ	New	DIAMOND OFFSHORE DRILLING IN	$1,761,000	–	100,000	–	0.04%	–
ADAP	New	ADAPTIMMUNE THERAPEUTICS PLCsponds adr	$1,410,000	–	200,000	–	0.03%	–
OPHT	Sell	OPHTHOTECH CORP	$1,384,000	-45.8%	30,000	-40.0%	0.03%	-49.1%
ADRO	New	ADURO BIOTECH INC	$1,243,000	–	100,000	–	0.02%	–
NVAX	New	NOVAVAX INC	$1,040,000	–	500,000	–	0.02%	–
CERE	Exit	CERES INC	$0	–	-1,024,020	–	-0.01%	–
SAGE	Exit	SAGE THERAPEUTICS INCcall	$0	–	-100,000	–	-0.06%	–
RDUS	Exit	RADIUS HEALTH INCcall	$0	–	-100,000	–	-0.08%	–
C	Exit	CITIGROUP INC	$0	–	-250,000	–	-0.22%	–
VRTX	Exit	VERTEX PHARMACEUTICALS INCcall	$0	–	-150,000	–	-0.27%	–
REGN	Exit	REGENERON PHARMACEUTICALS	$0	–	-50,000	–	-0.36%	–

Q2 2016

			Value		Shares		↓ Weighting
BUFF	New	BLUE BUFFALO PET PRODS INC	$2,683,809,000	–	114,987,547	–	55.40%	–
LXRX	New	LEXICON PHARMACEUTICALS INC	$825,383,000	–	57,517,977	–	17.04%	–
WW	New	WEIGHT WATCHERS INTL INC NEW	$342,426,000	–	29,443,300	–	7.07%	–
GS	New	GOLDMAN SACHS GROUP INCcall	$185,725,000	–	1,250,000	–	3.83%	–
BAC	New	BANK AMER CORPcall	$66,350,000	–	5,000,000	–	1.37%	–
INCY	New	INCYTE CORP	$49,988,000	–	625,000	–	1.03%	–
REGN	New	REGENERON PHARMACEUTICALScall	$41,908,000	–	120,000	–	0.86%	–
ALNY	New	ALNYLAM PHARMACEUTICALS INC	$39,398,000	–	710,000	–	0.81%	–
WMT	New	WAL-MART STORES INCcall	$36,510,000	–	500,000	–	0.75%	–
BIIB	New	BIOGEN INCcall	$36,273,000	–	150,000	–	0.75%	–
BABA	New	ALIBABA GROUP HLDG LTDsponsored ads	$31,812,000	–	400,000	–	0.66%	–
GS	New	GOLDMAN SACHS GROUP INC	$29,716,000	–	200,000	–	0.61%	–
GOOGL	New	ALPHABET INCcall	$28,141,000	–	40,000	–	0.58%	–
BMRN	New	BIOMARIN PHARMACEUTICAL INC	$27,230,000	–	350,000	–	0.56%	–
MET	New	METLIFE INCcall	$19,915,000	–	500,000	–	0.41%	–
NKTR	New	NEKTAR THERAPEUTICS	$19,922,000	–	1,400,000	–	0.41%	–
CELG	New	CELGENE CORPcall	$19,726,000	–	200,000	–	0.41%	–
BLUE	New	BLUEBIRD BIO INC	$19,481,000	–	450,000	–	0.40%	–
REGN	New	REGENERON PHARMACEUTICALS	$17,462,000	–	50,000	–	0.36%	–
3106PS	New	DELPHI AUTOMOTIVE PLC	$17,215,000	–	275,000	–	0.36%	–
ALNY	New	ALNYLAM PHARMACEUTICALS INCcall	$16,647,000	–	300,000	–	0.34%	–
KITE	New	KITE PHARMA INC	$16,250,000	–	325,000	–	0.34%	–
TSLA	New	TESLA MTRS INC	$15,921,000	–	75,000	–	0.33%	–
AGIO	New	AGIOS PHARMACEUTICALS INC	$15,711,000	–	375,000	–	0.32%	–
JPM	New	JPMORGAN CHASE & COcall	$15,535,000	–	250,000	–	0.32%	–
IBM	New	INTERNATIONAL BUSINESS MACHScall	$15,178,000	–	100,000	–	0.31%	–
BAC	New	BANK AMER CORP	$14,597,000	–	1,100,000	–	0.30%	–
ARRY	New	ARRAY BIOPHARMA INC	$13,777,000	–	3,870,000	–	0.28%	–
VRTX	New	VERTEX PHARMACEUTICALS INCcall	$12,903,000	–	150,000	–	0.27%	–
USFD	New	US FOODS HLDG CORP	$12,120,000	–	500,000	–	0.25%	–
C	New	CITIGROUP INC	$10,598,000	–	250,000	–	0.22%	–
MS	New	MORGAN STANLEY	$10,392,000	–	400,000	–	0.22%	–
MET	New	METLIFE INC	$9,958,000	–	250,000	–	0.21%	–
MCRB	New	SERES THERAPEUTICS INC	$9,006,000	–	310,000	–	0.19%	–
JUNO	New	JUNO THERAPEUTICS INC	$7,688,000	–	200,000	–	0.16%	–
FOLD	New	AMICUS THERAPEUTICS INC	$6,825,000	–	1,250,000	–	0.14%	–
SPNC	New	SPECTRANETICS CORP	$6,549,000	–	350,000	–	0.14%	–
AVXS	New	AVEXIS INC	$6,155,000	–	161,900	–	0.13%	–
HZNP	New	HORIZON PHARMA PLC	$5,765,000	–	350,000	–	0.12%	–
CLLS	New	CELLECTIS S Asponsored ads	$5,584,000	–	210,000	–	0.12%	–
JD	New	JD COM INCcall	$5,308,000	–	250,000	–	0.11%	–
NTLA	New	INTELLIA THERAPEUTICS INC	$4,804,000	–	225,000	–	0.10%	–
BLUE	New	BLUEBIRD BIO INCcall	$4,329,000	–	100,000	–	0.09%	–
NBIX	New	NEUROCRINE BIOSCIENCES INC	$4,318,000	–	95,000	–	0.09%	–
RXDX	New	IGNYTA INC	$4,065,000	–	750,000	–	0.08%	–
AGEN	New	AGENUS INC	$4,050,000	–	1,000,000	–	0.08%	–
CCXI	New	CHEMOCENTRYX INC	$4,041,000	–	900,000	–	0.08%	–
RDUS	New	RADIUS HEALTH INCcall	$3,675,000	–	100,000	–	0.08%	–
RARE	New	ULTRAGENYX PHARMACEUTICAL IN	$3,668,000	–	75,000	–	0.08%	–
RDUS	New	RADIUS HEALTH INC	$3,675,000	–	100,000	–	0.08%	–
XLRN	New	ACCELERON PHARMA INC	$3,398,000	–	100,000	–	0.07%	–
BTX	New	BIOTIME INC	$3,346,000	–	1,282,050	–	0.07%	–
SAGE	New	SAGE THERAPEUTICS INCcall	$3,013,000	–	100,000	–	0.06%	–
CLDX	New	CELLDEX THERAPEUTICS INC NEW	$2,963,000	–	675,000	–	0.06%	–
IRWD	New	IRONWOOD PHARMACEUTICALS INC	$2,836,000	–	216,879	–	0.06%	–
OPHT	New	OPHTHOTECH CORP	$2,552,000	–	50,000	–	0.05%	–
ONCE	New	SPARK THERAPEUTICS INC	$2,557,000	–	50,000	–	0.05%	–
GBT	New	GLOBAL BLOOD THERAPEUTICS IN	$2,074,000	–	125,000	–	0.04%	–
AGEN	New	AGENUS INCcall	$2,025,000	–	500,000	–	0.04%	–
JUNO	New	JUNO THERAPEUTICS INCcall	$1,922,000	–	50,000	–	0.04%	–
SRPT	New	SAREPTA THERAPEUTICS INCcall	$1,907,000	–	100,000	–	0.04%	–
CEMP	New	CEMPRA INC	$1,649,000	–	100,000	–	0.03%	–
DMTX	New	DIMENSION THERAPEUTICS INC	$1,650,000	–	275,000	–	0.03%	–
RGNX	New	REGENXBIO INC	$1,600,000	–	200,000	–	0.03%	–
AEGR	New	AEGERION PHARMACEUTICALS INC	$1,490,000	–	1,000,000	–	0.03%	–
NK	New	NANTKWEST INC	$1,400,000	–	225,000	–	0.03%	–
CERE	New	CERES INC	$400,000	–	1,024,020	–	0.01%	–
OCX	New	ONCOCYTE CORPORATION	$228,000	–	64,102	–	0.01%	–
CLCD	New	COLUCID PHARMACEUTICALS INC	$46,000	–	5,575	–	0.00%	–

Q4 2015

			Value		Shares		↓ Weighting
CLCD	Exit	COLUCID PHARMACEUTICALS INC	$0	–	-5,575	–	0.00%	–
XOMA	Exit	XOMA CORP DELcall	$0	–	-400,000	–	-0.01%	–
CERE	Exit	CERES INC	$0	–	-1,024,020	–	-0.02%	–
SPNC	Exit	SPECTRANETICS CORP	$0	–	-100,000	–	-0.03%	–
ARRY	Exit	ARRAY BIOPHARMA INCcall	$0	–	-300,000	–	-0.03%	–
JMEI	Exit	JUMEI INTL HLDG LTDcall	$0	–	-150,000	–	-0.03%	–
HLI	Exit	HOULIHAN LOKEY INCcl a	$0	–	-75,000	–	-0.04%	–
PARNF	Exit	PARNELL PHARMACEUT HLDGS LTD	$0	–	-500,000	–	-0.04%	–
NK	Exit	NANTKWEST INC	$0	–	-175,000	–	-0.04%	–
IRWD	Exit	IRONWOOD PHARMACEUTICALS INC	$0	–	-216,879	–	-0.05%	–
A104PS	Exit	HILTON WORLDWIDE HLDGS INC	$0	–	-100,000	–	-0.05%	–
AGEN	Exit	AGENUS INC	$0	–	-550,000	–	-0.06%	–
RGNX	Exit	REGENXBIO INC	$0	–	-117,400	–	-0.06%	–
CLLS	Exit	CELLECTIS S Asponsored ads	$0	–	-125,000	–	-0.07%	–
BTX	Exit	BIOTIME INC	$0	–	-1,282,050	–	-0.09%	–
CLDX	Exit	CELLDEX THERAPEUTICS INC NEW	$0	–	-375,000	–	-0.09%	–
ALNY	Exit	ALNYLAM PHARMACEUTICALS INCcall	$0	–	-50,000	–	-0.09%	–
ISIS	Exit	ISIS PHARMACEUTICALS INCcall	$0	–	-100,000	–	-0.09%	–
RXDX	Exit	IGNYTA INC	$0	–	-475,000	–	-0.09%	–
LC	Exit	LENDINGCLUB CORPcall	$0	–	-325,000	–	-0.10%	–
BLUE	Exit	BLUEBIRD BIO INCcall	$0	–	-50,000	–	-0.10%	–
JMEI	Exit	JUMEI INTL HLDG LTDsponsored adr	$0	–	-500,000	–	-0.11%	–
CCXI	Exit	CHEMOCENTRYX INC	$0	–	-900,000	–	-0.12%	–
MCRB	Exit	SERES THERAPEUTICS INC	$0	–	-200,000	–	-0.13%	–
MS	Exit	MORGAN STANLEY	$0	–	-250,000	–	-0.18%	–
EEM	Exit	ISHARES TRcall	$0	–	-250,000	–	-0.18%	–
KITE	Exit	KITE PHARMA INCcall	$0	–	-150,000	–	-0.19%	–
JUNO	Exit	JUNO THERAPEUTICS INC	$0	–	-235,000	–	-0.21%	–
TWX	Exit	TIME WARNER INCcall	$0	–	-150,000	–	-0.23%	–
BMRN	Exit	BIOMARIN PHARMACEUTICAL INCcall	$0	–	-100,000	–	-0.24%	–
YUM	Exit	YUM BRANDS INC	$0	–	-150,000	–	-0.27%	–
AMZN	Exit	AMAZON COM INCcall	$0	–	-25,000	–	-0.29%	–
GM	Exit	GENERAL MTRS CO	$0	–	-450,000	–	-0.30%	–
MU	Exit	MICRON TECHNOLOGY INCcall	$0	–	-1,000,000	–	-0.34%	–
LC	Exit	LENDINGCLUB CORP	$0	–	-1,175,000	–	-0.35%	–
BAC	Exit	BANK AMER CORP	$0	–	-1,000,000	–	-0.35%	–
CCI	Exit	CROWN CASTLE INTL CORP NEWcall	$0	–	-200,000	–	-0.35%	–
AGIO	Exit	AGIOS PHARMACEUTICALS INC	$0	–	-225,000	–	-0.36%	–
ISIS	Exit	ISIS PHARMACEUTICALS INC	$0	–	-400,000	–	-0.36%	–
ARRY	Exit	ARRAY BIOPHARMA INC	$0	–	-3,710,000	–	-0.38%	–
BABA	Exit	ALIBABA GROUP HLDG LTDsponsored ads	$0	–	-300,000	–	-0.40%	–
MCD	Exit	MCDONALDS CORPcall	$0	–	-200,000	–	-0.44%	–
NKTR	Exit	NEKTAR THERAPEUTICS	$0	–	-1,800,000	–	-0.44%	–
YUM	Exit	YUM BRANDS INCcall	$0	–	-250,000	–	-0.45%	–
KITE	Exit	KITE PHARMA INC	$0	–	-390,000	–	-0.48%	–
AAPL	Exit	APPLE INCcall	$0	–	-200,000	–	-0.49%	–
LNKD	Exit	LINKEDIN CORP	$0	–	-125,000	–	-0.53%	–
MRK	Exit	MERCK & CO INC NEWcall	$0	–	-500,000	–	-0.55%	–
TEVA	Exit	TEVA PHARMACEUTICAL INDS LTDcall	$0	–	-450,000	–	-0.57%	–
QCOM	Exit	QUALCOMM INCcall	$0	–	-500,000	–	-0.60%	–
BLUE	Exit	BLUEBIRD BIO INC	$0	–	-315,000	–	-0.60%	–
MA	Exit	MASTERCARD INCcl a	$0	–	-300,000	–	-0.60%	–
C	Exit	CITIGROUP INCcall	$0	–	-550,000	–	-0.61%	–
XBI	Exit	SPDR SERIES TRUSTcall	$0	–	-450,000	–	-0.63%	–
GILD	Exit	GILEAD SCIENCES INCcall	$0	–	-300,000	–	-0.66%	–
BABA	Exit	ALIBABA GROUP HLDG LTDcall	$0	–	-500,000	–	-0.66%	–
BMY	Exit	BRISTOL MYERS SQUIBB COcall	$0	–	-500,000	–	-0.66%	–
GM	Exit	GENERAL MTRS COcall	$0	–	-1,000,000	–	-0.67%	–
MS	Exit	MORGAN STANLEYcall	$0	–	-1,000,000	–	-0.70%	–
AXP	Exit	AMERICAN EXPRESS COcall	$0	–	-450,000	–	-0.74%	–
ENDP	Exit	ENDO INTL PLCcall	$0	–	-500,000	–	-0.77%	–
ALNY	Exit	ALNYLAM PHARMACEUTICALS INC	$0	–	-435,000	–	-0.78%	–
GOOG	Exit	GOOGLE INCcall	$0	–	-60,000	–	-0.82%	–
BMRN	Exit	BIOMARIN PHARMACEUTICAL INC	$0	–	-440,000	–	-1.04%	–
BAC	Exit	BANK AMER CORPcall	$0	–	-3,000,000	–	-1.04%	–
GE	Exit	GENERAL ELECTRIC COcall	$0	–	-2,000,000	–	-1.13%	–
INCY	Exit	INCYTE CORP	$0	–	-490,000	–	-1.21%	–
MET	Exit	METLIFE INCcall	$0	–	-1,250,000	–	-1.32%	–
CELG	Exit	CELGENE CORPcall	$0	–	-650,000	–	-1.57%	–
JPM	Exit	JPMORGAN CHASE & COcall	$0	–	-1,300,000	–	-1.77%	–
GS	Exit	GOLDMAN SACHS GROUP INCcall	$0	–	-500,000	–	-1.94%	–
WMT	Exit	WAL-MART STORES INCcall	$0	–	-1,665,000	–	-2.41%	–
BIIB	Exit	BIOGEN INCcall	$0	–	-400,000	–	-2.61%	–
WW	Exit	WEIGHT WATCHERS INTL INC NEW	$0	–	-29,443,300	–	-4.20%	–
LXRX	Exit	LEXICON PHARMACEUTICALS INC	$0	–	-57,517,978	–	-13.80%	–
BUFF	Exit	BLUE BUFFALO PET PRODS INC	$0	–	-114,987,547	–	-46.01%	–

Q3 2015

			Value		Shares		↓ Weighting
BUFF	New	BLUE BUFFALO PET PRODS INC	$2,059,427,000	–	114,987,547	–	46.01%	–
BIIB	Buy	BIOGEN INCcall	$116,724,000	-17.4%	400,000	+14.3%	2.61%	-57.1%
GS	Buy	GOLDMAN SACHS GROUP INCcall	$86,880,000	+38.7%	500,000	+66.7%	1.94%	-28.0%
JPM	Buy	JPMORGAN CHASE & COcall	$79,261,000	+95.0%	1,300,000	+116.7%	1.77%	+1.2%
CELG	Buy	CELGENE CORPcall	$70,311,000	+1.3%	650,000	+8.3%	1.57%	-47.4%
MET	Buy	METLIFE INCcall	$58,938,000	+75.4%	1,250,000	+108.3%	1.32%	-8.9%
INCY	Buy	INCYTE CORP	$54,062,000	+8.1%	490,000	+2.1%	1.21%	-43.9%
BAC	Buy	BANK AMER CORPcall	$46,740,000	+9.8%	3,000,000	+20.0%	1.04%	-43.0%
BMRN	Buy	BIOMARIN PHARMACEUTICAL INC	$46,341,000	-22.1%	440,000	+1.1%	1.04%	-59.6%
GOOG	Sell	GOOGLE INCcall	$36,505,000	-68.8%	60,000	-73.3%	0.82%	-83.8%
ALNY	Sell	ALNYLAM PHARMACEUTICALS INC	$34,957,000	-35.9%	435,000	-4.4%	0.78%	-66.7%
ENDP	New	ENDO INTL PLCcall	$34,640,000	–	500,000	–	0.77%	–
MS	Buy	MORGAN STANLEYcall	$31,500,000	+8.3%	1,000,000	+33.3%	0.70%	-43.8%
BMY	New	BRISTOL MYERS SQUIBB COcall	$29,600,000	–	500,000	–	0.66%	–
BABA	Buy	ALIBABA GROUP HLDG LTDcall	$29,485,000	+258.4%	500,000	+400.0%	0.66%	+86.2%
GILD	Buy	GILEAD SCIENCES INCcall	$29,457,000	+151.6%	300,000	+200.0%	0.66%	+30.6%
XBI	New	SPDR SERIES TRUSTcall	$28,013,000	–	450,000	–	0.63%	–
C	Buy	CITIGROUP INCcall	$27,286,000	+23.5%	550,000	+37.5%	0.61%	-35.9%
MA	Sell	MASTERCARD INCcl a	$27,036,000	-27.7%	300,000	-25.0%	0.60%	-62.5%
BLUE	Buy	BLUEBIRD BIO INC	$26,948,000	-20.0%	315,000	+57.5%	0.60%	-58.5%
LNKD	Sell	LINKEDIN CORP	$23,766,000	-12.5%	125,000	-4.9%	0.53%	-54.6%
AAPL	New	APPLE INCcall	$22,060,000	–	200,000	–	0.49%	–
KITE	Sell	KITE PHARMA INC	$21,715,000	-16.2%	390,000	-8.2%	0.48%	-56.5%
YUM	Sell	YUM BRANDS INCcall	$19,988,000	-55.6%	250,000	-50.0%	0.45%	-76.9%
NKTR	Buy	NEKTAR THERAPEUTICS	$19,728,000	-7.2%	1,800,000	+5.9%	0.44%	-51.8%
BABA	Sell	ALIBABA GROUP HLDG LTDsponsored ads	$17,691,000	-57.0%	300,000	-40.0%	0.40%	-77.7%
AGIO	Buy	AGIOS PHARMACEUTICALS INC	$15,883,000	-10.7%	225,000	+40.6%	0.36%	-53.6%
LC	Buy	LENDINGCLUB CORP	$15,545,000	-2.0%	1,175,000	+9.3%	0.35%	-49.2%
AMZN	New	AMAZON COM INCcall	$12,797,000	–	25,000	–	0.29%	–
YUM	New	YUM BRANDS INC	$11,993,000	–	150,000	–	0.27%	–
BMRN	Sell	BIOMARIN PHARMACEUTICAL INCcall	$10,532,000	-61.5%	100,000	-50.0%	0.24%	-80.1%
TWX	New	TIME WARNER INCcall	$10,313,000	–	150,000	–	0.23%	–
JUNO	Buy	JUNO THERAPEUTICS INC	$9,562,000	-5.6%	235,000	+23.7%	0.21%	-50.9%
KITE	New	KITE PHARMA INCcall	$8,352,000	–	150,000	–	0.19%	–
EEM	New	ISHARES TRcall	$8,195,000	–	250,000	–	0.18%	–
MS	New	MORGAN STANLEY	$7,875,000	–	250,000	–	0.18%	–
MCRB	Buy	SERES THERAPEUTICS INC	$5,928,000	-10.7%	200,000	+25.0%	0.13%	-53.8%
BLUE	New	BLUEBIRD BIO INCcall	$4,278,000	–	50,000	–	0.10%	–
LC	Buy	LENDINGCLUB CORPcall	$4,300,000	+16.6%	325,000	+30.0%	0.10%	-39.6%
RXDX	Buy	IGNYTA INC	$4,171,000	-38.6%	475,000	+5.6%	0.09%	-68.2%
ALNY	New	ALNYLAM PHARMACEUTICALS INCcall	$4,018,000	–	50,000	–	0.09%	–
ISIS	New	ISIS PHARMACEUTICALS INCcall	$4,042,000	–	100,000	–	0.09%	–
CLDX	Buy	CELLDEX THERAPEUTICS INC NEW	$3,953,000	-37.3%	375,000	+50.0%	0.09%	-67.5%
RGNX	New	REGENXBIO INC	$2,586,000	–	117,400	–	0.06%	–
AGEN	Buy	AGENUS INC	$2,530,000	-44.7%	550,000	+3.8%	0.06%	-71.1%
A104PS	Sell	HILTON WORLDWIDE HLDGS INC	$2,294,000	-84.9%	100,000	-81.8%	0.05%	-92.2%
NK	New	NANTKWEST INC	$2,006,000	–	175,000	–	0.04%	–
HLI	New	HOULIHAN LOKEY INCcl a	$1,635,000	–	75,000	–	0.04%	–
JMEI	New	JUMEI INTL HLDG LTDcall	$1,481,000	–	150,000	–	0.03%	–
SPNC	New	SPECTRANETICS CORP	$1,179,000	–	100,000	–	0.03%	–
MRTX	Exit	MIRATI THERAPEUTICS INC	$0	–	-61,276	–	-0.08%	–
CSLT	Exit	CASTLIGHT HEALTH INCcl b	$0	–	-250,000	–	-0.09%	–
BTX	Exit	BIOTIME INCcall	$0	–	-600,000	–	-0.09%	–
JD	Exit	JD COM INCspon adr cl a	$0	–	-100,000	–	-0.15%	–
YY	Exit	YY INC	$0	–	-50,000	–	-0.15%	–
XOMA	Exit	XOMA CORP DEL	$0	–	-1,200,000	–	-0.20%	–
RLGY	Exit	REALOGY HLDGS CORP	$0	–	-100,000	–	-0.20%	–
DAL	Exit	DELTA AIR LINES INC DEL	$0	–	-200,000	–	-0.35%	–
AAL	Exit	AMERICAN AIRLS GROUP INCcall	$0	–	-250,000	–	-0.43%	–
AAL	Exit	AMERICAN AIRLS GROUP INC	$0	–	-400,000	–	-0.69%	–
AER	Exit	AERCAP HOLDINGS NV	$0	–	-375,000	–	-0.74%	–
MBBYF	Exit	MOBILEYE N V AMSTELVEEN	$0	–	-500,000	–	-1.14%	–
AMZN	Exit	AMAZON COM INC	$0	–	-65,000	–	-1.22%	–

Q2 2015

			Value		Shares		↓ Weighting
LXRX	New	LEXICON PHARMACEUTICALS INC	$463,019,000	–	57,517,978	–	19.93%	–
WW	New	WEIGHT WATCHERS INTL INC NEW	$142,800,000	–	29,443,300	–	6.15%	–
BIIB	New	BIOGEN INCcall	$141,379,000	–	350,000	–	6.08%	–
WMT	New	WAL-MART STORES INCcall	$118,098,000	–	1,665,000	–	5.08%	–
GOOG	New	GOOGLE INCcall	$117,115,000	–	225,000	–	5.04%	–
CELG	New	CELGENE CORPcall	$69,441,000	–	600,000	–	2.99%	–
GS	New	GOLDMAN SACHS GROUP INCcall	$62,637,000	–	300,000	–	2.70%	–
BMRN	New	BIOMARIN PHARMACEUTICAL INC	$59,499,000	–	435,000	–	2.56%	–
ALNY	New	ALNYLAM PHARMACEUTICALS INC	$54,541,000	–	455,000	–	2.35%	–
GE	New	GENERAL ELECTRIC COcall	$53,140,000	–	2,000,000	–	2.29%	–
INCY	New	INCYTE CORP	$50,021,000	–	480,000	–	2.15%	–
YUM	New	YUM BRANDS INCcall	$45,040,000	–	500,000	–	1.94%	–
BAC	New	BANK AMER CORPcall	$42,550,000	–	2,500,000	–	1.83%	–
BABA	New	ALIBABA GROUP HLDG LTDsponsored ads	$41,135,000	–	500,000	–	1.77%	–
JPM	New	JPMORGAN CHASE & COcall	$40,656,000	–	600,000	–	1.75%	–
MA	New	MASTERCARD INCcl a	$37,392,000	–	400,000	–	1.61%	–
AXP	New	AMERICAN EXPRESS COcall	$34,974,000	–	450,000	–	1.50%	–
BLUE	New	BLUEBIRD BIO INC	$33,674,000	–	200,000	–	1.45%	–
MET	New	METLIFE INCcall	$33,594,000	–	600,000	–	1.45%	–
GM	New	GENERAL MTRS COcall	$33,330,000	–	1,000,000	–	1.44%	–
QCOM	New	QUALCOMM INCcall	$31,315,000	–	500,000	–	1.35%	–
MS	New	MORGAN STANLEYcall	$29,093,000	–	750,000	–	1.25%	–
MRK	New	MERCK & CO INC NEWcall	$28,465,000	–	500,000	–	1.22%	–
AMZN	New	AMAZON COM INC	$28,216,000	–	65,000	–	1.22%	–
BMRN	New	BIOMARIN PHARMACEUTICAL INCcall	$27,356,000	–	200,000	–	1.18%	–
LNKD	New	LINKEDIN CORP	$27,172,000	–	131,500	–	1.17%	–
ARRY	New	ARRAY BIOPHARMA INC	$26,749,000	–	3,710,000	–	1.15%	–
TEVA	New	TEVA PHARMACEUTICAL INDS LTDcall	$26,595,000	–	450,000	–	1.14%	–
MBBYF	New	MOBILEYE N V AMSTELVEEN	$26,585,000	–	500,000	–	1.14%	–
KITE	New	KITE PHARMA INC	$25,912,000	–	425,000	–	1.12%	–
ISIS	New	ISIS PHARMACEUTICALS INC	$23,020,000	–	400,000	–	0.99%	–
C	New	CITIGROUP INCcall	$22,096,000	–	400,000	–	0.95%	–
NKTR	New	NEKTAR THERAPEUTICS	$21,267,000	–	1,700,000	–	0.92%	–
MCD	New	MCDONALDS CORPcall	$19,014,000	–	200,000	–	0.82%	–
MU	New	MICRON TECHNOLOGY INCcall	$18,840,000	–	1,000,000	–	0.81%	–
AGIO	New	AGIOS PHARMACEUTICALS INC	$17,782,000	–	160,000	–	0.76%	–
AER	New	AERCAP HOLDINGS NV	$17,171,000	–	375,000	–	0.74%	–
BAC	New	BANK AMER CORP	$17,020,000	–	1,000,000	–	0.73%	–
CCI	New	CROWN CASTLE INTL CORP NEWcall	$16,060,000	–	200,000	–	0.69%	–
AAL	New	AMERICAN AIRLS GROUP INC	$15,974,000	–	400,000	–	0.69%	–
LC	New	LENDINGCLUB CORP	$15,856,000	–	1,075,000	–	0.68%	–
A104PS	New	HILTON WORLDWIDE HLDGS INC	$15,153,000	–	550,000	–	0.65%	–
GM	New	GENERAL MTRS CO	$14,999,000	–	450,000	–	0.65%	–
GILD	New	GILEAD SCIENCES INCcall	$11,708,000	–	100,000	–	0.50%	–
JMEI	New	JUMEI INTL HLDG LTDsponsored adr	$11,420,000	–	500,000	–	0.49%	–
JUNO	New	JUNO THERAPEUTICS INC	$10,133,000	–	190,000	–	0.44%	–
AAL	New	AMERICAN AIRLS GROUP INCcall	$9,984,000	–	250,000	–	0.43%	–
DAL	New	DELTA AIR LINES INC DEL	$8,216,000	–	200,000	–	0.35%	–
BABA	New	ALIBABA GROUP HLDG LTDcall	$8,227,000	–	100,000	–	0.35%	–
CCXI	New	CHEMOCENTRYX INC	$7,407,000	–	900,000	–	0.32%	–
RXDX	New	IGNYTA INC	$6,791,000	–	450,000	–	0.29%	–
MCRB	New	SERES THERAPEUTICS INC	$6,642,000	–	160,057	–	0.29%	–
CLDX	New	CELLDEX THERAPEUTICS INC NEW	$6,305,000	–	250,000	–	0.27%	–
RLGY	New	REALOGY HLDGS CORP	$4,672,000	–	100,000	–	0.20%	–
BTX	New	BIOTIME INC	$4,654,000	–	1,282,050	–	0.20%	–
XOMA	New	XOMA CORP DEL	$4,656,000	–	1,200,000	–	0.20%	–
AGEN	New	AGENUS INC	$4,575,000	–	530,090	–	0.20%	–
CLLS	New	CELLECTIS S Asponsored ads	$4,510,000	–	125,000	–	0.19%	–
LC	New	LENDINGCLUB CORPcall	$3,688,000	–	250,000	–	0.16%	–
YY	New	YY INC	$3,476,000	–	50,000	–	0.15%	–
JD	New	JD COM INCspon adr cl a	$3,410,000	–	100,000	–	0.15%	–
IRWD	New	IRONWOOD PHARMACEUTICALS INC	$2,616,000	–	216,879	–	0.11%	–
PARNF	New	PARNELL PHARMACEUT HLDGS LTD	$2,475,000	–	500,000	–	0.11%	–
BTX	New	BIOTIME INCcall	$2,178,000	–	600,000	–	0.09%	–
ARRY	New	ARRAY BIOPHARMA INCcall	$2,163,000	–	300,000	–	0.09%	–
CSLT	New	CASTLIGHT HEALTH INCcl b	$2,035,000	–	250,000	–	0.09%	–
CERE	New	CERES INC	$1,997,000	–	1,024,020	–	0.09%	–
MRTX	New	MIRATI THERAPEUTICS INC	$1,928,000	–	61,276	–	0.08%	–
XOMA	New	XOMA CORP DELcall	$1,552,000	–	400,000	–	0.07%	–
CLCD	New	COLUCID PHARMACEUTICALS INC	$50,000	–	5,575	–	0.00%	–

Q4 2014

			Value		Shares		↓ Weighting
CCXI	Exit	CHEMOCENTRYX INCcall	$0	–	-100,000	–	-0.02%	–
AMRN	Exit	AMARIN CORP PLCcall	$0	–	-500,000	–	-0.02%	–
SFXEQ	Exit	SFX ENTMT INC	$0	–	-250,000	–	-0.05%	–
CCXI	Exit	CHEMOCENTRYX INC	$0	–	-275,000	–	-0.05%	–
AGEN	Exit	AGENUS INC	$0	–	-410,130	–	-0.05%	–
CSLT	Exit	CASTLIGHT HEALTH INCcall	$0	–	-100,000	–	-0.05%	–
J106OPTLDIV	Exit	CBS OUTDOOR AMERS INC	$0	–	-65,145	–	-0.07%	–
STML	Exit	STEMLINE THERAPEUTICS INC	$0	–	-170,000	–	-0.08%	–
IRWD	Exit	IRONWOOD PHARMACEUTICALS INC	$0	–	-216,879	–	-0.10%	–
PARNF	Exit	PARNELL PHARMACEUT HLDGS LTD	$0	–	-500,000	–	-0.11%	–
SPHS	Exit	SOPHIRIS BIO INC	$0	–	-1,000,000	–	-0.11%	–
RXDX	Exit	IGNYTA INC	$0	–	-375,000	–	-0.11%	–
NG	Exit	NOVAGOLD RES INCcall	$0	–	-1,000,000	–	-0.11%	–
CSLT	Exit	CASTLIGHT HEALTH INCcl b	$0	–	-250,000	–	-0.12%	–
XOMA	Exit	XOMA CORP DELcall	$0	–	-800,000	–	-0.12%	–
CERE	Exit	CERES INC	$0	–	-8,192,167	–	-0.12%	–
ACOR	Exit	ACORDA THERAPEUTICS INCcall	$0	–	-100,000	–	-0.12%	–
CFG	Exit	CITIZENS FINL GROUP INC	$0	–	-150,000	–	-0.13%	–
KORS	Exit	MICHAEL KORS HLDGS LTD	$0	–	-50,000	–	-0.13%	–
OCN	Exit	OCWEN FINL CORPcall	$0	–	-150,000	–	-0.14%	–
RL	Exit	RALPH LAUREN CORPcl a	$0	–	-25,000	–	-0.15%	–
XOMA	Exit	XOMA CORP DEL	$0	–	-1,000,000	–	-0.16%	–
IMGN	Exit	IMMUNOGEN INCcall	$0	–	-400,000	–	-0.16%	–
MRTX	Exit	MIRATI THERAPEUTICS INC	$0	–	-250,000	–	-0.16%	–
NEOG	Exit	NEOGEN CORP	$0	–	-125,000	–	-0.18%	–
MS	Exit	MORGAN STANLEYcall	$0	–	-150,000	–	-0.19%	–
MBBYF	Exit	MOBILEYE N V AMSTELVEEN	$0	–	-100,000	–	-0.20%	–
AIG	Exit	AMERICAN INTL GROUP INC	$0	–	-100,000	–	-0.20%	–
RLGY	Exit	REALOGY HLDGS CORPcall	$0	–	-150,000	–	-0.20%	–
MON	Exit	MONSANTO CO NEWcall	$0	–	-50,000	–	-0.21%	–
HOG	Exit	HARLEY DAVIDSON INC	$0	–	-100,000	–	-0.21%	–
PCYC	Exit	PHARMACYCLICS INCcall	$0	–	-50,000	–	-0.22%	–
KITE	Exit	KITE PHARMA INC	$0	–	-210,000	–	-0.22%	–
3106PS	Exit	DELPHI AUTOMOTIVE PLCcall	$0	–	-100,000	–	-0.23%	–
FCX	Exit	FREEPORT-MCMORAN INCcall	$0	–	-200,000	–	-0.24%	–
FSL	Exit	FREESCALE SEMICONDUCTOR LTD	$0	–	-350,000	–	-0.25%	–
FOXA	Exit	TWENTY FIRST CENTY FOX INCcl a	$0	–	-200,000	–	-0.25%	–
COF	Exit	CAPITAL ONE FINL CORPcall	$0	–	-100,000	–	-0.30%	–
ACOR	Exit	ACORDA THERAPEUTICS INC	$0	–	-250,000	–	-0.31%	–
BLUE	Exit	BLUEBIRD BIO INC	$0	–	-250,000	–	-0.33%	–
UAL	Exit	UNITED CONTL HLDGS INCcall	$0	–	-200,000	–	-0.34%	–
GM	Exit	GENERAL MTRS CO	$0	–	-300,000	–	-0.35%	–
SLB	Exit	SCHLUMBERGER LTDcall	$0	–	-100,000	–	-0.37%	–
ARRY	Exit	ARRAY BIOPHARMA INC	$0	–	-3,000,000	–	-0.39%	–
DAL	Exit	DELTA AIR LINES INC DEL	$0	–	-300,000	–	-0.40%	–
AGIO	Exit	AGIOS PHARMACEUTICALS INC	$0	–	-190,000	–	-0.43%	–
AVNR	Exit	AVANIR PHARMACEUTICALS INCcall	$0	–	-1,000,000	–	-0.44%	–
3106PS	Exit	DELPHI AUTOMOTIVE PLC	$0	–	-200,000	–	-0.45%	–
MA	Exit	MASTERCARD INCcl a	$0	–	-175,000	–	-0.48%	–
C	Exit	CITIGROUP INCcall	$0	–	-250,000	–	-0.48%	–
CTSH	Exit	COGNIZANT TECHNOLOGY SOLUTIOcall	$0	–	-300,000	–	-0.49%	–
HON	Exit	HONEYWELL INTL INCcall	$0	–	-150,000	–	-0.51%	–
GOOG	Exit	GOOGLE INCcall	$0	–	-25,000	–	-0.53%	–
BMRN	Exit	BIOMARIN PHARMACEUTICAL INCcall	$0	–	-200,000	–	-0.53%	–
V	Exit	VISA INCcall	$0	–	-70,000	–	-0.55%	–
QCOM	Exit	QUALCOMM INCcall	$0	–	-200,000	–	-0.55%	–
IMGN	Exit	IMMUNOGEN INC	$0	–	-1,500,000	–	-0.58%	–
ITB	Exit	ISHAREScall	$0	–	-750,000	–	-0.62%	–
ISIS	Exit	ISIS PHARMACEUTICALS INC	$0	–	-455,000	–	-0.65%	–
YUM	Exit	YUM BRANDS INCcall	$0	–	-250,000	–	-0.66%	–
NKTR	Exit	NEKTAR THERAPEUTICS	$0	–	-1,650,000	–	-0.73%	–
INCY	Exit	INCYTE CORP	$0	–	-440,000	–	-0.79%	–
ALNY	Exit	ALNYLAM PHARMACEUTICALS INC	$0	–	-300,000	–	-0.86%	–
AVNR	Exit	AVANIR PHARMACEUTICALS INCcl a new	$0	–	-2,000,000	–	-0.88%	–
VMC	Exit	VULCAN MATLS COcall	$0	–	-400,000	–	-0.89%	–
GE	Exit	GENERAL ELECTRIC COcall	$0	–	-1,000,000	–	-0.94%	–
PCYC	Exit	PHARMACYCLICS INC	$0	–	-225,000	–	-0.97%	–
XLI	Exit	SELECT SECTOR SPDR TRcall	$0	–	-500,000	–	-0.98%	–
GM	Exit	GENERAL MTRS COcall	$0	–	-850,000	–	-1.00%	–
BAC	Exit	BANK AMER CORPcall	$0	–	-1,750,000	–	-1.10%	–
AUXL	Exit	AUXILIUM PHARMACEUTICALS INC	$0	–	-1,000,000	–	-1.10%	–
TEVA	Exit	TEVA PHARMACEUTICAL INDS LTDcall	$0	–	-600,000	–	-1.19%	–
AIG	Exit	AMERICAN INTL GROUP INCcall	$0	–	-600,000	–	-1.19%	–
BMRN	Exit	BIOMARIN PHARMACEUTICAL INC	$0	–	-550,000	–	-1.46%	–
JPM	Exit	JPMORGAN CHASE & COcall	$0	–	-750,000	–	-1.66%	–
BIIB	Exit	BIOGEN IDEC INCcall	$0	–	-142,000	–	-1.73%	–
MRK	Exit	MERCK & CO INC NEWcall	$0	–	-800,000	–	-1.74%	–
MET	Exit	METLIFE INCcall	$0	–	-900,000	–	-1.78%	–
GWW	Exit	GRAINGER W W INCcall	$0	–	-200,000	–	-1.85%	–
BMY	Exit	BRISTOL MYERS SQUIBB COcall	$0	–	-1,000,000	–	-1.88%	–
BABA	Exit	ALIBABA GROUP HLDG LTDsponsored ads	$0	–	-600,000	–	-1.96%	–
AUXL	Exit	AUXILIUM PHARMACEUTICALS INCcall	$0	–	-2,275,000	–	-2.50%	–
IWM	Exit	ISHARES TRcall	$0	–	-800,000	–	-3.22%	–
SPY	Exit	SPDR S&P 500 ETF TRcall	$0	–	-1,200,000	–	-8.70%	–
LXRX	Exit	LEXICON PHARMACEUTICALS INC	$0	–	-253,372,135	–	-13.15%	–
WW	Exit	WEIGHT WATCHERS INTL INC NEW	$0	–	-29,443,300	–	-29.73%	–

Q3 2014

			Value		Shares		↓ Weighting
WW	Buy	WEIGHT WATCHERS INTL INC NEW	$807,924,000	+39.3%	29,443,300	+2.4%	29.73%	+26.8%
SPY	Buy	SPDR S&P 500 ETF TRcall	$236,424,000	+20.8%	1,200,000	+20.0%	8.70%	+10.0%
IWM	Buy	ISHARES TRcall	$87,480,000	+268.2%	800,000	+300.0%	3.22%	+235.0%
AUXL	Buy	AUXILIUM PHARMACEUTICALS INCcall	$67,909,000	+207.8%	2,275,000	+106.8%	2.50%	+180.2%
BABA	New	ALIBABA GROUP HLDG LTDsponsored ads	$53,310,000	–	600,000	–	1.96%	–
BMY	Buy	BRISTOL MYERS SQUIBB COcall	$51,180,000	+31.9%	1,000,000	+25.0%	1.88%	+20.1%
GWW	New	GRAINGER W W INCcall	$50,330,000	–	200,000	–	1.85%	–
MRK	Sell	MERCK & CO INC NEWcall	$47,424,000	-36.9%	800,000	-38.5%	1.74%	-42.6%
BIIB	Buy	BIOGEN IDEC INCcall	$46,975,000	+49.0%	142,000	+42.0%	1.73%	+35.6%
JPM	Buy	JPMORGAN CHASE & COcall	$45,180,000	+56.8%	750,000	+50.0%	1.66%	+42.7%
BMRN	Buy	BIOMARIN PHARMACEUTICAL INC	$39,688,000	+21.5%	550,000	+4.8%	1.46%	+10.7%
AIG	Buy	AMERICAN INTL GROUP INCcall	$32,412,000	+18.8%	600,000	+20.0%	1.19%	+8.2%
TEVA	Sell	TEVA PHARMACEUTICAL INDS LTDcall	$32,250,000	-12.1%	600,000	-14.3%	1.19%	-20.0%
AUXL	Sell	AUXILIUM PHARMACEUTICALS INC	$29,850,000	-26.2%	1,000,000	-50.4%	1.10%	-32.7%
BAC	Sell	BANK AMER CORPcall	$29,838,000	-22.3%	1,750,000	-30.0%	1.10%	-29.3%
XLI	New	SELECT SECTOR SPDR TRcall	$26,575,000	–	500,000	–	0.98%	–
PCYC	Sell	PHARMACYCLICS INC	$26,422,000	+9.1%	225,000	-16.7%	0.97%	-0.7%
GE	Sell	GENERAL ELECTRIC COcall	$25,620,000	-35.0%	1,000,000	-33.3%	0.94%	-40.8%
VMC	Buy	VULCAN MATLS COcall	$24,092,000	+89.0%	400,000	+100.0%	0.89%	+72.2%
INCY	Buy	INCYTE CORP	$21,582,000	+0.6%	440,000	+15.8%	0.79%	-8.4%
NKTR	Buy	NEKTAR THERAPEUTICS	$19,916,000	+15.1%	1,650,000	+22.2%	0.73%	+4.7%
ITB	Sell	ISHAREScall	$16,868,000	-54.7%	750,000	-50.0%	0.62%	-58.7%
V	New	VISA INCcall	$14,936,000	–	70,000	–	0.55%	–
BMRN	Sell	BIOMARIN PHARMACEUTICAL INCcall	$14,432,000	-42.0%	200,000	-50.0%	0.53%	-47.2%
GOOG	Sell	GOOGLE INCcall	$14,434,000	-49.8%	25,000	-50.0%	0.53%	-54.3%
HON	Buy	HONEYWELL INTL INCcall	$13,968,000	+50.3%	150,000	+50.0%	0.51%	+36.7%
CTSH	Buy	COGNIZANT TECHNOLOGY SOLUTIOcall	$13,431,000	+37.3%	300,000	+50.0%	0.49%	+25.1%
C	Sell	CITIGROUP INCcall	$12,955,000	-45.0%	250,000	-50.0%	0.48%	-49.9%
MA	New	MASTERCARD INCcl a	$12,936,000	–	175,000	–	0.48%	–
3106PS	Buy	DELPHI AUTOMOTIVE PLC	$12,268,000	+19.0%	200,000	+33.3%	0.45%	+8.2%
AGIO	Buy	AGIOS PHARMACEUTICALS INC	$11,657,000	+45.4%	190,000	+8.6%	0.43%	+32.4%
DAL	New	DELTA AIR LINES INC DEL	$10,845,000	–	300,000	–	0.40%	–
SLB	New	SCHLUMBERGER LTDcall	$10,169,000	–	100,000	–	0.37%	–
GM	Sell	GENERAL MTRS CO	$9,582,000	-24.6%	300,000	-14.3%	0.35%	-31.3%
ACOR	Sell	ACORDA THERAPEUTICS INC	$8,470,000	-40.9%	250,000	-41.2%	0.31%	-46.1%
FSL	New	FREESCALE SEMICONDUCTOR LTD	$6,836,000	–	350,000	–	0.25%	–
FOXA	New	TWENTY FIRST CENTY FOX INCcl a	$6,858,000	–	200,000	–	0.25%	–
3106PS	Sell	DELPHI AUTOMOTIVE PLCcall	$6,134,000	-64.3%	100,000	-60.0%	0.23%	-67.5%
KITE	New	KITE PHARMA INC	$5,985,000	–	210,000	–	0.22%	–
PCYC	Sell	PHARMACYCLICS INCcall	$5,872,000	-56.4%	50,000	-66.7%	0.22%	-60.3%
HOG	New	HARLEY DAVIDSON INC	$5,820,000	–	100,000	–	0.21%	–
MON	New	MONSANTO CO NEWcall	$5,626,000	–	50,000	–	0.21%	–
MBBYF	New	MOBILEYE N V AMSTELVEEN	$5,359,000	–	100,000	–	0.20%	–
IMGN	Sell	IMMUNOGEN INCcall	$4,236,000	-35.0%	400,000	-27.3%	0.16%	-40.9%
OCN	Sell	OCWEN FINL CORPcall	$3,927,000	-76.5%	150,000	-66.7%	0.14%	-78.5%
KORS	New	MICHAEL KORS HLDGS LTD	$3,570,000	–	50,000	–	0.13%	–
CFG	New	CITIZENS FINL GROUP INC	$3,513,000	–	150,000	–	0.13%	–
ACOR	New	ACORDA THERAPEUTICS INCcall	$3,388,000	–	100,000	–	0.12%	–
NG	Sell	NOVAGOLD RES INCcall	$3,030,000	-40.0%	1,000,000	-16.7%	0.11%	-45.1%
RXDX	Buy	IGNYTA INC	$3,023,000	+10.9%	375,000	+25.0%	0.11%	+0.9%
PARNF	New	PARNELL PHARMACEUT HLDGS LTD	$2,875,000	–	500,000	–	0.11%	–
J106OPTLDIV	New	CBS OUTDOOR AMERS INC	$1,950,000	–	65,145	–	0.07%	–
CCXI	New	CHEMOCENTRYX INCcall	$450,000	–	100,000	–	0.02%	–
BAC	Exit	BANK OF AMERICA CORPORATION	$0	–	-100,000	–	-0.06%	–
AMBI	Exit	AMBIT BIOSCIENCES CORP	$0	–	-250,000	–	-0.07%	–
RDN	Exit	RADIAN GROUP INC	$0	–	-200,000	–	-0.12%	–
OCN	Exit	OCWEN FINL CORP	$0	–	-100,000	–	-0.15%	–
ARMK	Exit	ARAMARK	$0	–	-200,000	–	-0.21%	–
CMCSK	Exit	COMCAST CORP NEWcl a spl	$0	–	-100,000	–	-0.22%	–
TEX	Exit	TEREX CORP NEW	$0	–	-200,000	–	-0.33%	–
GOOGL	Exit	GOOGLE INCcall	$0	–	-15,000	–	-0.36%	–
ZTS	Exit	ZOETIS INCcall	$0	–	-300,000	–	-0.39%	–
NKTR	Exit	NEKTAR THERAPEUTICScall	$0	–	-800,000	–	-0.42%	–
FURX	Exit	FURIEX PHARMACEUTICALS INCcall	$0	–	-100,000	–	-0.43%	–
BRFS	Exit	BRF SAcall	$0	–	-500,000	–	-0.49%	–
LLY	Exit	LILLY ELI & COcall	$0	–	-200,000	–	-0.50%	–
C	Exit	CITIGROUP INC	$0	–	-300,000	–	-0.57%	–
AMZN	Exit	AMAZON COM INC	$0	–	-50,000	–	-0.66%	–
CL	Exit	COLGATE PALMOLIVE COcall	$0	–	-250,000	–	-0.69%	–
GILD	Exit	GILEAD SCIENCES INCcall	$0	–	-250,000	–	-0.84%	–
CIT	Exit	CIT GROUP INCcall	$0	–	-750,000	–	-1.39%	–
AMGN	Exit	AMGEN INCcall	$0	–	-400,000	–	-1.91%	–

Q2 2014

			Value		Shares		↓ Weighting
WW	New	WEIGHT WATCHERS INTL INC NEW	$579,869,000	–	28,749,089	–	23.44%	–
LXRX	New	LEXICON PHARMACEUTICALS INC	$407,929,000	–	253,372,135	–	16.49%	–
SPY	New	SPDR S&P 500 ETF TRUSTcall	$195,720,000	–	1,000,000	–	7.91%	–
MRK	New	MERCK & CO INC NEWcall	$75,205,000	–	1,300,000	–	3.04%	–
MET	New	METLIFE INCcall	$50,004,000	–	900,000	–	2.02%	–
AMGN	New	AMGEN INCcall	$47,348,000	–	400,000	–	1.91%	–
AUXL	New	AUXILIUM PHARMACEUTICALS INC	$40,421,000	–	2,015,000	–	1.63%	–
GE	New	GENERAL ELECTRIC COcall	$39,420,000	–	1,500,000	–	1.59%	–
BMY	New	BRISTOL MYERS SQUIBB COcall	$38,808,000	–	800,000	–	1.57%	–
BAC	New	BANK OF AMERICA CORPORATIONcall	$38,425,000	–	2,500,000	–	1.55%	–
ITB	New	ISHAREScall	$37,200,000	–	1,500,000	–	1.50%	–
TEVA	New	TEVA PHARMACEUTICAL INDS LTDcall	$36,694,000	–	700,000	–	1.48%	–
CIT	New	CIT GROUP INCcall	$34,320,000	–	750,000	–	1.39%	–
BMRN	New	BIOMARIN PHARMACEUTICAL INC	$32,660,000	–	525,000	–	1.32%	–
BIIB	New	BIOGEN IDEC INCcall	$31,531,000	–	100,000	–	1.28%	–
GM	New	GENERAL MTRS COcall	$30,855,000	–	850,000	–	1.25%	–
JPM	New	JPMORGAN CHASE & COcall	$28,810,000	–	500,000	–	1.16%	–
GOOG	New	GOOGLE INCcall	$28,764,000	–	50,000	–	1.16%	–
AIG	New	AMERICAN INTL GROUP INCcall	$27,290,000	–	500,000	–	1.10%	–
BMRN	New	BIOMARIN PHARMACEUTICAL INCcall	$24,884,000	–	400,000	–	1.01%	–
PCYC	New	PHARMACYCLICS INC	$24,222,000	–	270,000	–	0.98%	–
IWM	New	ISHAREScall	$23,762,000	–	200,000	–	0.96%	–
C	New	CITIGROUP INCcall	$23,550,000	–	500,000	–	0.95%	–
AUXL	New	AUXILIUM PHARMACEUTICALS INCcall	$22,066,000	–	1,100,000	–	0.89%	–
INCY	New	INCYTE CORP	$21,447,000	–	380,000	–	0.87%	–
GILD	New	GILEAD SCIENCES INCcall	$20,728,000	–	250,000	–	0.84%	–
YUM	New	YUM! BRANDS INCcall	$20,300,000	–	250,000	–	0.82%	–
ALNY	New	ALNYLAM PHARMACEUTICALS INC	$18,951,000	–	300,000	–	0.77%	–
IMGN	New	IMMUNOGEN INC	$17,775,000	–	1,500,000	–	0.72%	–
NKTR	New	NEKTAR THERAPEUTICS	$17,307,000	–	1,350,000	–	0.70%	–
3106PS	New	DELPHI AUTOMOTIVE PLCcall	$17,185,000	–	250,000	–	0.70%	–
CL	New	COLGATE PALMOLIVE COcall	$17,045,000	–	250,000	–	0.69%	–
OCN	New	OCWEN FINL CORPcall	$16,695,000	–	450,000	–	0.68%	–
AMZN	New	AMAZON COM INC	$16,239,000	–	50,000	–	0.66%	–
QCOM	New	QUALCOMM INCcall	$15,840,000	–	200,000	–	0.64%	–
ISIS	New	ISIS PHARMACEUTICALS INC	$15,675,000	–	455,000	–	0.63%	–
ACOR	New	ACORDA THERAPEUTICS INC	$14,327,000	–	425,000	–	0.58%	–
C	New	CITIGROUP INC	$14,130,000	–	300,000	–	0.57%	–
ARRY	New	ARRAY BIOPHARMA INC	$13,680,000	–	3,000,000	–	0.55%	–
PCYC	New	PHARMACYCLICS INCcall	$13,457,000	–	150,000	–	0.54%	–
VMC	New	VULCAN MATLS COcall	$12,750,000	–	200,000	–	0.52%	–
GM	New	GENERAL MTRS CO	$12,705,000	–	350,000	–	0.51%	–
LLY	New	LILLY ELI & COcall	$12,434,000	–	200,000	–	0.50%	–
BRFS	New	BRF SAcall	$12,155,000	–	500,000	–	0.49%	–
AVNR	New	AVANIR PHARMACEUTICALS INCcl a new	$11,280,000	–	2,000,000	–	0.46%	–
FURX	New	FURIEX PHARMACEUTICALS INCcall	$10,618,000	–	100,000	–	0.43%	–
3106PS	New	DELPHI AUTOMOTIVE PLC	$10,311,000	–	150,000	–	0.42%	–
NKTR	New	NEKTAR THERAPEUTICScall	$10,256,000	–	800,000	–	0.42%	–
CTSH	New	COGNIZANT TECHNOLOGY SOLUTIOcall	$9,782,000	–	200,000	–	0.40%	–
ZTS	New	ZOETIS INCcall	$9,681,000	–	300,000	–	0.39%	–
BLUE	New	BLUEBIRD BIO INC	$9,643,000	–	250,000	–	0.39%	–
HON	New	HONEYWELL INTL INCcall	$9,295,000	–	100,000	–	0.38%	–
GOOGL	New	GOOGLE INCcall	$8,770,000	–	15,000	–	0.36%	–
COF	New	CAPITAL ONE FINL CORPcall	$8,260,000	–	100,000	–	0.33%	–
UAL	New	UNITED CONTL HLDGS INCcall	$8,214,000	–	200,000	–	0.33%	–
TEX	New	TEREX CORP NEW	$8,220,000	–	200,000	–	0.33%	–
AGIO	New	AGIOS PHARMACEUTICALS INC	$8,019,000	–	175,000	–	0.32%	–
FCX	New	FREEPORT-MCMORAN COPPER & GOcall	$7,300,000	–	200,000	–	0.30%	–
IMGN	New	IMMUNOGEN INCcall	$6,518,000	–	550,000	–	0.26%	–
RLGY	New	REALOGY HLDGS CORPcall	$5,657,000	–	150,000	–	0.23%	–
AVNR	New	AVANIR PHARMACEUTICALS INCcall	$5,640,000	–	1,000,000	–	0.23%	–
CERE	New	CERES INC	$5,489,000	–	8,192,167	–	0.22%	–
AIG	New	AMERICAN INTL GROUP INC	$5,458,000	–	100,000	–	0.22%	–
CMCSK	New	COMCAST CORP NEWcl a spl	$5,333,000	–	100,000	–	0.22%	–
ARMK	New	ARAMARK	$5,176,000	–	200,000	–	0.21%	–
NEOG	New	NEOGEN CORP	$5,059,000	–	125,000	–	0.20%	–
NG	New	NOVAGOLD RES INCcall	$5,052,000	–	1,200,000	–	0.20%	–
MRTX	New	MIRATI THERAPEUTICS INC	$5,000,000	–	250,000	–	0.20%	–
MS	New	MORGAN STANLEYcall	$4,850,000	–	150,000	–	0.20%	–
XOMA	New	XOMA CORP DEL	$4,590,000	–	1,000,000	–	0.19%	–
RL	New	RALPH LAUREN CORPcl a	$4,017,000	–	25,000	–	0.16%	–
CSLT	New	CASTLIGHT HEALTH INCcl b	$3,800,000	–	250,000	–	0.15%	–
OCN	New	OCWEN FINL CORP	$3,710,000	–	100,000	–	0.15%	–
XOMA	New	XOMA CORP DELcall	$3,672,000	–	800,000	–	0.15%	–
IRWD	New	IRONWOOD PHARMACEUTICALS INC	$3,325,000	–	216,879	–	0.13%	–
RDN	New	RADIAN GROUP INC	$2,962,000	–	200,000	–	0.12%	–
RXDX	New	IGNYTA INC	$2,727,000	–	300,000	–	0.11%	–
STML	New	STEMLINE THERAPEUTICS INC	$2,494,000	–	170,000	–	0.10%	–
SPHS	New	SOPHIRIS BIO INC	$2,240,000	–	1,000,000	–	0.09%	–
SFXEQ	New	SFX ENTMT INC	$2,025,000	–	250,000	–	0.08%	–
AMBI	New	AMBIT BIOSCIENCES CORP	$1,728,000	–	250,000	–	0.07%	–
CCXI	New	CHEMOCENTRYX INC	$1,609,000	–	275,000	–	0.06%	–
BAC	New	BANK OF AMERICA CORPORATION	$1,537,000	–	100,000	–	0.06%	–
CSLT	New	CASTLIGHT HEALTH INCcall	$1,520,000	–	100,000	–	0.06%	–
AGEN	New	AGENUS INC	$1,321,000	–	410,130	–	0.05%	–
AMRN	New	AMARIN CORP PLCcall	$880,000	–	500,000	–	0.04%	–

Q4 2013

			Value		Shares		↓ Weighting
BIOD	Exit	BIODEL INC	$0	–	-290,740	–	-0.03%	–
AGEN	Exit	AGENUS INC	$0	–	-410,130	–	-0.04%	–
AVNR	Exit	AVANIR PHARMACEUTICALS INCcall	$0	–	-300,000	–	-0.04%	–
SMT	Exit	SMART TECHNOLOGIES INCcl a sub vtg s	$0	–	-550,000	–	-0.05%	–
CCXI	Exit	CHEMOCENTRYX INC	$0	–	-275,000	–	-0.05%	–
LEN	Exit	LENNAR CORPcl a	$0	–	-50,000	–	-0.06%	–
AGIO	Exit	AGIOS PHARMACEUTICALS INC	$0	–	-70,000	–	-0.06%	–
MTOR	Exit	MERITOR INCcall	$0	–	-250,000	–	-0.06%	–
SUNEQ	Exit	SUNEDISON INC	$0	–	-250,000	–	-0.06%	–
NG	Exit	NOVAGOLD RES INC	$0	–	-1,000,000	–	-0.08%	–
IRWD	Exit	IRONWOOD PHARMACEUTICALS INC	$0	–	-216,879	–	-0.08%	–
MS	Exit	MORGAN STANLEY	$0	–	-100,000	–	-0.09%	–
NG	Exit	NOVAGOLD RES INCcall	$0	–	-1,200,000	–	-0.09%	–
LEG	Exit	LEGGETT & PLATT INCcall	$0	–	-100,000	–	-0.10%	–
QCOM	Exit	QUALCOMM INC	$0	–	-50,000	–	-0.11%	–
PGEM	Exit	PLY GEM HLDGS INC	$0	–	-254,226	–	-0.12%	–
FLDM	Exit	FLUIDIGM CORP DEL	$0	–	-168,706	–	-0.12%	–
BLUE	Exit	BLUEBIRD BIO INC	$0	–	-150,000	–	-0.13%	–
PHM	Exit	PULTE GROUP INCcall	$0	–	-250,000	–	-0.13%	–
CPAC	Exit	CEMENTOS PACASMAYO S A Aspon adr rep 5	$0	–	-379,609	–	-0.14%	–
SPHS	Exit	SOPHIRIS BIO INC	$0	–	-1,000,000	–	-0.15%	–
AIG	Exit	AMERICAN INTL GROUP INC	$0	–	-100,000	–	-0.16%	–
CIT	Exit	CIT GROUP INCcall	$0	–	-100,000	–	-0.16%	–
GDX	Exit	MARKET VECTORS ETF TRcall	$0	–	-200,000	–	-0.16%	–
IMGN	Exit	IMMUNOGEN INCcall	$0	–	-300,000	–	-0.17%	–
MAS	Exit	MASCO CORPcall	$0	–	-250,000	–	-0.17%	–
MTG	Exit	MGIC INVT CORP WIS	$0	–	-750,000	–	-0.18%	–
DG	Exit	DOLLAR GEN CORP NEW	$0	–	-100,000	–	-0.18%	–
MTOR	Exit	MERITOR INC	$0	–	-750,100	–	-0.19%	–
CERE	Exit	CERES INC	$0	–	-4,192,167	–	-0.20%	–
MDLZ	Exit	MONDELEZ INTL INCcall	$0	–	-200,000	–	-0.20%	–
GS	Exit	GOLDMAN SACHS GROUP INC	$0	–	-40,000	–	-0.21%	–
AMRN	Exit	AMARIN CORP PLCcall	$0	–	-1,000,000	–	-0.21%	–
FCX	Exit	FREEPORT-MCMORAN COPPER & GOcall	$0	–	-200,000	–	-0.22%	–
AFFX	Exit	AFFYMETRIX INC	$0	–	-1,200,000	–	-0.24%	–
KORS	Exit	MICHAEL KORS HLDGS LTD	$0	–	-100,000	–	-0.24%	–
UAL	Exit	UNITED CONTL HLDGS INC	$0	–	-250,000	–	-0.25%	–
RLGY	Exit	REALOGY HLDGS CORP	$0	–	-200,000	–	-0.28%	–
TEX	Exit	TEREX CORP NEW	$0	–	-275,000	–	-0.30%	–
ZTS	Exit	ZOETIS INCcall	$0	–	-300,000	–	-0.30%	–
EWW	Exit	ISHARES INCcall	$0	–	-150,000	–	-0.31%	–
F	Exit	FORD MTR CO DEL	$0	–	-600,000	–	-0.33%	–
ESV	Exit	ENSCO PLCcall	$0	–	-200,000	–	-0.35%	–
GM	Exit	GENERAL MTRS COcall	$0	–	-300,000	–	-0.35%	–
ITB	Exit	ISHARES INCcall	$0	–	-500,000	–	-0.36%	–
XOMA	Exit	XOMA CORP DEL	$0	–	-2,500,000	–	-0.36%	–
GS	Exit	GOLDMAN SACHS GROUP INCcall	$0	–	-75,000	–	-0.39%	–
ESRX	Exit	EXPRESS SCRIPTS HLDG COcall	$0	–	-200,000	–	-0.40%	–
AVNR	Exit	AVANIR PHARMACEUTICALS INCcl a new	$0	–	-3,100,000	–	-0.43%	–
BMRN	Exit	BIOMARIN PHARMACEUTICAL INCcall	$0	–	-200,000	–	-0.47%	–
RLGY	Exit	REALOGY HLDGS CORPcall	$0	–	-350,000	–	-0.49%	–
HIG	Exit	HARTFORD FINL SVCS GROUP INCcall	$0	–	-500,000	–	-0.51%	–
AMGN	Exit	AMGEN INC	$0	–	-150,000	–	-0.55%	–
BMRN	Exit	BIOMARIN PHARMACEUTICAL INC	$0	–	-250,000	–	-0.59%	–
MJN	Exit	MEAD JOHNSON NUTRITION COcall	$0	–	-250,000	–	-0.60%	–
F	Exit	FORD MTR CO DELcall	$0	–	-1,100,000	–	-0.60%	–
ARRY	Exit	ARRAY BIOPHARMA INC	$0	–	-3,000,000	–	-0.61%	–
C	Exit	CITIGROUP INCcall	$0	–	-400,000	–	-0.63%	–
AMGN	Exit	AMGEN INCcall	$0	–	-200,000	–	-0.73%	–
MRK	Exit	MERCK & CO INC NEWcall	$0	–	-500,000	–	-0.78%	–
M	Exit	MACYS INCcall	$0	–	-550,000	–	-0.78%	–
PEP	Exit	PEPSICO INCcall	$0	–	-300,000	–	-0.78%	–
NKTR	Exit	NEKTAR THERAPEUTICS	$0	–	-2,300,000	–	-0.78%	–
BAC	Exit	BANK OF AMERICA CORPORATIONcall	$0	–	-1,750,000	–	-0.79%	–
OCN	Exit	OCWEN FINL CORPcall	$0	–	-450,000	–	-0.82%	–
TEVA	Exit	TEVA PHARMACEUTICAL INDS LTDcall	$0	–	-700,000	–	-0.86%	–
IMGN	Exit	IMMUNOGEN INC	$0	–	-1,650,000	–	-0.91%	–
YUM	Exit	YUM BRANDS INCcall	$0	–	-400,000	–	-0.93%	–
LLY	Exit	LILLY ELI & COcall	$0	–	-600,000	–	-0.98%	–
JPM	Exit	JPMORGAN CHASE & COcall	$0	–	-700,000	–	-1.17%	–
ACOR	Exit	ACORDA THERAPEUTICS INC	$0	–	-1,095,170	–	-1.22%	–
WFC	Exit	WELLS FARGO & CO NEWcall	$0	–	-1,000,000	–	-1.34%	–
FURX	Exit	FURIEX PHARMACEUTICALS INC	$0	–	-971,051	–	-1.39%	–
QCOM	Exit	QUALCOMM INCcall	$0	–	-700,000	–	-1.53%	–
AUXL	Exit	AUXILIUM PHARMACEUTICALS INC	$0	–	-2,637,200	–	-1.56%	–
AAPL	Exit	APPLE INCcall	$0	–	-175,000	–	-2.72%	–
GE	Exit	GENERAL ELECTRIC COcall	$0	–	-3,800,000	–	-2.96%	–
SPY	Exit	SPDR S&P 500 ETF TRcall	$0	–	-1,500,000	–	-8.20%	–
LXRX	Exit	LEXICON PHARMACEUTICALS INC	$0	–	-253,372,135	–	-19.63%	–
WW	Exit	WEIGHT WATCHERS INTL INC NEW	$0	–	-28,749,089	–	-34.98%	–

Q3 2013

			Value		Shares		↓ Weighting
SPY	Buy	SPDR S&P 500 ETF TRcall	$252,015,000	+161.8%	1,500,000	+150.0%	8.20%	+171.0%
GE	Buy	GENERAL ELECTRIC COcall	$90,782,000	+179.6%	3,800,000	+171.4%	2.96%	+189.4%
AAPL	Buy	APPLE INCcall	$83,431,000	+50.3%	175,000	+25.0%	2.72%	+55.5%
QCOM	Sell	QUALCOMM INCcall	$47,124,000	-3.6%	700,000	-12.5%	1.53%	-0.3%
FURX	Buy	FURIEX PHARMACEUTICALS INC	$42,717,000	+37.1%	971,051	+6.2%	1.39%	+41.9%
WFC	Buy	WELLS FARGO & CO NEWcall	$41,320,000	+400.6%	1,000,000	+400.0%	1.34%	+417.3%
ACOR	Sell	ACORDA THERAPEUTICS INC	$37,455,000	-24.3%	1,095,170	-27.0%	1.22%	-21.7%
JPM	Buy	JPMORGAN CHASE & COcall	$35,917,000	+13.4%	700,000	+16.7%	1.17%	+17.3%
YUM	Buy	YUM BRANDS INCcall	$28,556,000	+105.9%	400,000	+100.0%	0.93%	+113.3%
IMGN	Sell	IMMUNOGEN INC	$28,083,000	-0.4%	1,650,000	-2.9%	0.91%	+3.0%
OCN	Buy	OCWEN FINL CORPcall	$25,097,000	+74.0%	450,000	+28.6%	0.82%	+80.0%
BAC	Buy	BANK OF AMERICA CORPORATIONcall	$24,150,000	+25.2%	1,750,000	+16.7%	0.79%	+29.5%
NKTR	Sell	NEKTAR THERAPEUTICS	$24,024,000	-16.8%	2,300,000	-8.0%	0.78%	-13.9%
PEP	New	PEPSICO INCcall	$23,850,000	–	300,000	–	0.78%	–
MRK	Sell	MERCK & CO INC NEWcall	$23,805,000	-35.9%	500,000	-37.5%	0.78%	-33.7%
M	New	MACYS INCcall	$23,799,000	–	550,000	–	0.78%	–
AMGN	Buy	AMGEN INCcall	$22,384,000	+353.8%	200,000	+300.0%	0.73%	+370.3%
C	Buy	CITIGROUP INCcall	$19,404,000	+34.8%	400,000	+33.3%	0.63%	+39.5%
F	Buy	FORD MTR CO DELcall	$18,557,000	+299.8%	1,100,000	+266.7%	0.60%	+313.7%
MJN	Buy	MEAD JOHNSON NUTRITION COcall	$18,565,000	+17.2%	250,000	+25.0%	0.60%	+21.0%
BMRN	Sell	BIOMARIN PHARMACEUTICAL INC	$18,043,000	-7.5%	250,000	-28.6%	0.59%	-4.4%
AMGN	Sell	AMGEN INC	$16,789,000	-2.8%	150,000	-14.3%	0.55%	+0.7%
RLGY	New	REALOGY HLDGS CORPcall	$15,057,000	–	350,000	–	0.49%	–
AVNR	Buy	AVANIR PHARMACEUTICALS INCcl a new	$13,113,000	+3.7%	3,100,000	+12.7%	0.43%	+7.3%
GS	Sell	GOLDMAN SACHS GROUP INCcall	$11,866,000	-47.7%	75,000	-50.0%	0.39%	-45.9%
ITB	New	ISHARES INCcall	$11,170,000	–	500,000	–	0.36%	–
GM	New	GENERAL MTRS COcall	$10,791,000	–	300,000	–	0.35%	–
ESV	New	ENSCO PLCcall	$10,750,000	–	200,000	–	0.35%	–
F	Buy	FORD MTR CO DEL	$10,122,000	+118.1%	600,000	+100.0%	0.33%	+126.0%
EWW	Sell	ISHARES INCcall	$9,584,000	-58.0%	150,000	-57.1%	0.31%	-56.6%
ZTS	Buy	ZOETIS INCcall	$9,336,000	+51.1%	300,000	+50.0%	0.30%	+56.7%
TEX	New	TEREX CORP NEW	$9,240,000	–	275,000	–	0.30%	–
RLGY	New	REALOGY HLDGS CORP	$8,604,000	–	200,000	–	0.28%	–
UAL	New	UNITED CONTL HLDGS INC	$7,678,000	–	250,000	–	0.25%	–
AFFX	Sell	AFFYMETRIX INC	$7,434,000	-42.3%	1,200,000	-58.6%	0.24%	-40.2%
GS	New	GOLDMAN SACHS GROUP INC	$6,328,000	–	40,000	–	0.21%	–
MDLZ	New	MONDELEZ INTL INCcall	$6,284,000	–	200,000	–	0.20%	–
MTOR	New	MERITOR INC	$5,896,000	–	750,100	–	0.19%	–
MTG	Sell	MGIC INVT CORP WIS	$5,460,000	+12.4%	750,000	-6.2%	0.18%	+16.3%
MAS	New	MASCO CORPcall	$5,320,000	–	250,000	–	0.17%	–
AIG	Sell	AMERICAN INTL GROUP INC	$4,863,000	-45.6%	100,000	-50.0%	0.16%	-43.8%
SPHS	New	SOPHIRIS BIO INC	$4,680,000	–	1,000,000	–	0.15%	–
CPAC	Sell	CEMENTOS PACASMAYO S A Aspon adr rep 5	$4,441,000	-12.8%	379,609	-5.1%	0.14%	-9.4%
PHM	New	PULTE GROUP INCcall	$4,125,000	–	250,000	–	0.13%	–
BLUE	New	BLUEBIRD BIO INC	$4,044,000	–	150,000	–	0.13%	–
FLDM	Sell	FLUIDIGM CORP DEL	$3,701,000	-32.3%	168,706	-46.1%	0.12%	-30.2%
PGEM	Buy	PLY GEM HLDGS INC	$3,554,000	+18.1%	254,226	+69.5%	0.12%	+22.1%
QCOM	New	QUALCOMM INC	$3,366,000	–	50,000	–	0.11%	–
LEG	New	LEGGETT & PLATT INCcall	$3,015,000	–	100,000	–	0.10%	–
MS	New	MORGAN STANLEY	$2,695,000	–	100,000	–	0.09%	–
SUNEQ	New	SUNEDISON INC	$1,993,000	–	250,000	–	0.06%	–
MTOR	Sell	MERITOR INCcall	$1,965,000	-72.1%	250,000	-75.0%	0.06%	-71.2%
AGIO	New	AGIOS PHARMACEUTICALS INC	$1,957,000	–	70,000	–	0.06%	–
LEN	New	LENNAR CORPcl a	$1,770,000	–	50,000	–	0.06%	–
SMT	Sell	SMART TECHNOLOGIES INCcl a sub vtg s	$1,546,000	+3.5%	550,000	-49.9%	0.05%	+6.4%
AVNR	Sell	AVANIR PHARMACEUTICALS INCcall	$1,269,000	-65.5%	300,000	-62.5%	0.04%	-64.7%
	Exit	MICROVISION INC DEL*w exp 07/23/201	$0	–	-360,515	–	0.00%	–
VVUS	Exit	VIVUS INCcall	$0	–	-200,000	–	-0.08%	–
FSLR	Exit	FIRST SOLAR INC	$0	–	-100,000	–	-0.14%	–
ARCO	Exit	ARCOS DORADOS HOLDINGS INCcall	$0	–	-400,000	–	-0.15%	–
FB	Exit	FACEBOOK INCcall	$0	–	-200,000	–	-0.16%	–
ITUB	Exit	ITAU UNIBANCO HLDG SAspon adr rep pfd	$0	–	-400,000	–	-0.16%	–
JPM	Exit	JPMORGAN CHASE & CO	$0	–	-100,000	–	-0.17%	–
SLB	Exit	SCHLUMBERGER LTD	$0	–	-75,000	–	-0.17%	–
KORS	Exit	MICHAEL KORS HLDGS LTDcall	$0	–	-100,000	–	-0.20%	–
FB	Exit	FACEBOOK INCcl a	$0	–	-250,000	–	-0.20%	–
ROC	Exit	ROCKWOOD HLDGS INCcall	$0	–	-100,000	–	-0.20%	–
MET	Exit	METLIFE INCcall	$0	–	-150,000	–	-0.22%	–
VLO	Exit	VALERO ENERGY CORP NEWcall	$0	–	-200,000	–	-0.22%	–
ITUB	Exit	ITAU UNIBANCO HLDG SAcall	$0	–	-550,000	–	-0.22%	–
EEM	Exit	ISHARES TRcall	$0	–	-200,000	–	-0.24%	–
ARCO	Exit	ARCOS DORADOS HOLDINGS INC	$0	–	-800,000	–	-0.29%	–
Q	Exit	QUINTILES TRANSNATIO HLDGS I	$0	–	-225,000	–	-0.30%	–
EWW	Exit	ISHARES INCmsci mexico cap	$0	–	-150,000	–	-0.31%	–
VRX	Exit	VALEANT PHARMACEUTICALS INTL	$0	–	-125,000	–	-0.34%	–
BRFS	Exit	BRF S Asponsored adr	$0	–	-500,000	–	-0.34%	–
EMR	Exit	EMERSON ELEC COcall	$0	–	-200,000	–	-0.34%	–
FRX	Exit	FOREST LABS INCcall	$0	–	-300,000	–	-0.39%	–
COF	Exit	CAPITAL ONE FINL CORPcall	$0	–	-200,000	–	-0.40%	–
OCN	Exit	OCWEN FINL CORP	$0	–	-350,000	–	-0.45%	–
MET	Exit	METLIFE INC	$0	–	-400,000	–	-0.58%	–
AAPL	Exit	APPLE INC	$0	–	-50,000	–	-0.62%	–
ONXX	Exit	ONYX PHARMACEUTICALS INCcall	$0	–	-300,000	–	-0.82%	–
ONXX	Exit	ONYX PHARMACEUTICALS INC	$0	–	-300,000	–	-0.82%	–
EWJ	Exit	ISHARES INCcall	$0	–	-2,500,000	–	-0.88%	–
EWZ	Exit	ISHARES INCcall	$0	–	-2,000,000	–	-2.76%	–

Q2 2013

			Value		Shares		↓ Weighting
WW	New	WEIGHT WATCHERS INTL INC NEW	$1,322,458,000	–	28,749,089	–	41.61%	–
LXRX	New	LEXICON PHARMACEUTICALS INC	$549,818,000	–	253,372,135	–	17.30%	–
SPY	New	SPDR S&P 500 ETF TRcall	$96,252,000	–	600,000	–	3.03%	–
EWZ	New	ISHARES INCcall	$87,720,000	–	2,000,000	–	2.76%	–
AAPL	New	APPLE INCcall	$55,514,000	–	140,000	–	1.75%	–
ACOR	New	ACORDA THERAPEUTICS INC	$49,485,000	–	1,500,000	–	1.56%	–
QCOM	New	QUALCOMM INCcall	$48,872,000	–	800,000	–	1.54%	–
AUXL	New	AUXILIUM PHARMACEUTICALS INC	$43,859,000	–	2,637,200	–	1.38%	–
MRK	New	MERCK & CO INC NEWcall	$37,160,000	–	800,000	–	1.17%	–
GE	New	GENERAL ELECTRIC COcall	$32,466,000	–	1,400,000	–	1.02%	–
JPM	New	JPMORGAN CHASE & COcall	$31,674,000	–	600,000	–	1.00%	–
FURX	New	FURIEX PHARMACEUTICALS INC	$31,155,000	–	914,442	–	0.98%	–
LLY	New	LILLY ELI & COcall	$29,472,000	–	600,000	–	0.93%	–
NKTR	New	NEKTAR THERAPEUTICS	$28,875,000	–	2,500,000	–	0.91%	–
IMGN	New	IMMUNOGEN INC	$28,203,000	–	1,700,000	–	0.89%	–
EWJ	New	ISHARES INCcall	$28,050,000	–	2,500,000	–	0.88%	–
TEVA	New	TEVA PHARMACEUTICAL INDS LTDcall	$27,440,000	–	700,000	–	0.86%	–
ONXX	New	ONYX PHARMACEUTICALS INC	$26,046,000	–	300,000	–	0.82%	–
ONXX	New	ONYX PHARMACEUTICALS INCcall	$26,046,000	–	300,000	–	0.82%	–
EWW	New	ISHARES INCcall	$22,837,000	–	350,000	–	0.72%	–
GS	New	GOLDMAN SACHS GROUP INCcall	$22,688,000	–	150,000	–	0.71%	–
AAPL	New	APPLE INC	$19,827,000	–	50,000	–	0.62%	–
BMRN	New	BIOMARIN PHARMACEUTICAL INC	$19,509,000	–	350,000	–	0.61%	–
BAC	New	BANK OF AMERICA CORPORATIONcall	$19,290,000	–	1,500,000	–	0.61%	–
MET	New	METLIFE INC	$18,304,000	–	400,000	–	0.58%	–
AMGN	New	AMGEN INC	$17,266,000	–	175,000	–	0.54%	–
MJN	New	MEAD JOHNSON NUTRITION COcall	$15,846,000	–	200,000	–	0.50%	–
HIG	New	HARTFORD FINL SVCS GROUP INCcall	$15,460,000	–	500,000	–	0.49%	–
OCN	New	OCWEN FINL CORPcall	$14,427,000	–	350,000	–	0.45%	–
OCN	New	OCWEN FINL CORP	$14,427,000	–	350,000	–	0.45%	–
C	New	CITIGROUP INCcall	$14,391,000	–	300,000	–	0.45%	–
YUM	New	YUM BRANDS INCcall	$13,868,000	–	200,000	–	0.44%	–
ARRY	New	ARRAY BIOPHARMA INC	$13,620,000	–	3,000,000	–	0.43%	–
CERE	New	CERES INC	$13,121,000	–	4,192,167	–	0.41%	–
AFFX	New	AFFYMETRIX INC	$12,876,000	–	2,900,000	–	0.40%	–
AVNR	New	AVANIR PHARMACEUTICALS INCcl a new	$12,650,000	–	2,750,000	–	0.40%	–
COF	New	CAPITAL ONE FINL CORPcall	$12,562,000	–	200,000	–	0.40%	–
ESRX	New	EXPRESS SCRIPTS HLDG COcall	$12,348,000	–	200,000	–	0.39%	–
FRX	New	FOREST LABS INCcall	$12,300,000	–	300,000	–	0.39%	–
BMRN	New	BIOMARIN PHARMACEUTICAL INCcall	$11,148,000	–	200,000	–	0.35%	–
EMR	New	EMERSON ELEC COcall	$10,908,000	–	200,000	–	0.34%	–
BRFS	New	BRF S Asponsored adr	$10,855,000	–	500,000	–	0.34%	–
VRX	New	VALEANT PHARMACEUTICALS INTL	$10,760,000	–	125,000	–	0.34%	–
EWW	New	ISHARES INCmsci mexico cap	$9,787,000	–	150,000	–	0.31%	–
Q	New	QUINTILES TRANSNATIO HLDGS I	$9,576,000	–	225,000	–	0.30%	–
ARCO	New	ARCOS DORADOS HOLDINGS INC	$9,344,000	–	800,000	–	0.29%	–
XOMA	New	XOMA CORP DEL	$9,075,000	–	2,500,000	–	0.29%	–
AIG	New	AMERICAN INTL GROUP INC	$8,940,000	–	200,000	–	0.28%	–
WFC	New	WELLS FARGO & CO NEWcall	$8,254,000	–	200,000	–	0.26%	–
EEM	New	ISHARES TRcall	$7,700,000	–	200,000	–	0.24%	–
ITUB	New	ITAU UNIBANCO HLDG SAcall	$7,106,000	–	550,000	–	0.22%	–
MTOR	New	MERITOR INCcall	$7,050,000	–	1,000,000	–	0.22%	–
VLO	New	VALERO ENERGY CORP NEWcall	$6,954,000	–	200,000	–	0.22%	–
MET	New	METLIFE INCcall	$6,864,000	–	150,000	–	0.22%	–
ROC	New	ROCKWOOD HLDGS INCcall	$6,403,000	–	100,000	–	0.20%	–
FB	New	FACEBOOK INCcl a	$6,220,000	–	250,000	–	0.20%	–
KORS	New	MICHAEL KORS HLDGS LTD	$6,202,000	–	100,000	–	0.20%	–
KORS	New	MICHAEL KORS HLDGS LTDcall	$6,202,000	–	100,000	–	0.20%	–
ZTS	New	ZOETIS INCcall	$6,178,000	–	200,000	–	0.19%	–
AMRN	New	AMARIN CORP PLCcall	$5,800,000	–	1,000,000	–	0.18%	–
FCX	New	FREEPORT-MCMORAN COPPER & GOcall	$5,522,000	–	200,000	–	0.17%	–
FLDM	New	FLUIDIGM CORP DEL	$5,463,000	–	312,899	–	0.17%	–
SLB	New	SCHLUMBERGER LTD	$5,375,000	–	75,000	–	0.17%	–
JPM	New	JPMORGAN CHASE & CO	$5,279,000	–	100,000	–	0.17%	–
ITUB	New	ITAU UNIBANCO HLDG SAspon adr rep pfd	$5,168,000	–	400,000	–	0.16%	–
CPAC	New	CEMENTOS PACASMAYO S A Aspon adr rep 5	$5,092,000	–	400,000	–	0.16%	–
DG	New	DOLLAR GEN CORP NEW	$5,043,000	–	100,000	–	0.16%	–
IMGN	New	IMMUNOGEN INCcall	$4,977,000	–	300,000	–	0.16%	–
FB	New	FACEBOOK INCcall	$4,976,000	–	200,000	–	0.16%	–
AMGN	New	AMGEN INCcall	$4,933,000	–	50,000	–	0.16%	–
GDX	New	MARKET VECTORS ETF TRcall	$4,898,000	–	200,000	–	0.15%	–
MTG	New	MGIC INVT CORP WIS	$4,856,000	–	800,000	–	0.15%	–
ARCO	New	ARCOS DORADOS HOLDINGS INCcall	$4,672,000	–	400,000	–	0.15%	–
CIT	New	CIT GROUP INCcall	$4,663,000	–	100,000	–	0.15%	–
F	New	FORD MTR CO DEL	$4,641,000	–	300,000	–	0.15%	–
F	New	FORD MTR CO DELcall	$4,641,000	–	300,000	–	0.15%	–
FSLR	New	FIRST SOLAR INC	$4,481,000	–	100,000	–	0.14%	–
CCXI	New	CHEMOCENTRYX INC	$3,889,000	–	275,000	–	0.12%	–
AVNR	New	AVANIR PHARMACEUTICALS INCcall	$3,680,000	–	800,000	–	0.12%	–
PGEM	New	PLY GEM HLDGS INC	$3,009,000	–	150,000	–	0.10%	–
NG	New	NOVAGOLD RES INCcall	$2,532,000	–	1,200,000	–	0.08%	–
VVUS	New	VIVUS INCcall	$2,516,000	–	200,000	–	0.08%	–
IRWD	New	IRONWOOD PHARMACEUTICALS INC	$2,154,000	–	216,879	–	0.07%	–
NG	New	NOVAGOLD RES INC	$2,110,000	–	1,000,000	–	0.07%	–
AGEN	New	AGENUS INC	$1,554,000	–	410,130	–	0.05%	–
SMT	New	SMART TECHNOLOGIES INCcl a sub vtg s	$1,494,000	–	1,098,369	–	0.05%	–
BIOD	New	BIODEL INC	$1,215,000	–	290,740	–	0.04%	–
	New	MICROVISION INC DEL*w exp 07/23/201	$11,000	–	360,515	–	0.00%	–

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