| UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO | 697,431 | $8,048 | 3.11% |
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| Nantahala Capital Management | 2,284,895 | $26,367,688 | 2.55% |
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| Sofinnova Investments, Inc. | 3,041,487 | $35,098,760 | 2.30% |
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| Paradigm Biocapital Advisors LP | 1,984,813 | $22,904,742 | 1.77% |
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| Affinity Asset Advisors, LLC | 300,000 | $3,462,000 | 1.21% |
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| Perceptive Advisors | 3,491,500 | $40,291,910 | 1.17% |
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| 683 Capital Management, LLC | 1,350,000 | $15,579,000 | 1.12% |
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| SPHERA FUNDS MANAGEMENT LTD. | 617,173 | $7,122,176 | 1.11% |
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| Samsara BioCapital, LLC | 396,000 | $4,569,840 | 0.80% |
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| Logos Global Management LP | 500,000 | $5,770,000 | 0.78% |
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| Rock Springs Capital Management LP | 2,536,144 | $29,267,102 | 0.70% |
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| Baker Brothers Advisors | 5,640,816 | $65,095,017 | 0.38% |
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| Tri Locum Partners LP | 82,052 | $946,880 | 0.35% |
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| Orbimed Advisors | 966,829 | $11,157,207 | 0.20% |
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| RTW INVESTMENTS, LP | 845,000 | $9,751,300 | 0.19% |
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| Woodline Partners LP | 1,213,884 | $14,008,221 | 0.17% |
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| SILVERARC CAPITAL MANAGEMENT, LLC | 30,715 | $354,451 | 0.11% |
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| PLATINUM INVESTMENT MANAGEMENT LTD | 268,211 | $3,095,155 | 0.11% |
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| Ikarian Capital, LLC | 49,031 | $565,817 | 0.09% |
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| Alyeska Investment Group, L.P. | 794,060 | $9,163,452 | 0.07% |
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