| PERKINS CAPITAL MANAGEMENT INC | 121,330 | $3,090 | 2.69% |
|---|
| SILVERARC CAPITAL MANAGEMENT, LLC | 229,451 | $5,844,117 | 1.81% |
|---|
| OBERWEIS ASSET MANAGEMENT INC/ | 482,310 | $12,284,436 | 1.49% |
|---|
| EFG Asset Management (North America) Corp. | 247,692 | $6,303,761 | 1.35% |
|---|
| ARK Investment Management | 7,828,292 | $199,386,601 | 1.32% |
|---|
| Parkman Healthcare Partners LLC | 211,960 | $5,398,621 | 0.94% |
|---|
| Nikko Asset Management Americas, Inc. | 3,249,013 | $82,654,891 | 0.87% |
|---|
| CLOUGH CAPITAL PARTNERS L P | 276,260 | $7,036,342 | 0.71% |
|---|
| ESSEX INVESTMENT MANAGEMENT CO LLC | 187,917 | $4,786,246 | 0.67% |
|---|
| ArrowMark Colorado Holdings LLC | 2,390,979 | $60,898,235 | 0.67% |
|---|
| Capital Impact Advisors, LLC | 21,550 | $548,879 | 0.60% |
|---|
| Granahan Investment Management | 591,682 | $15,070,141 | 0.46% |
|---|
| Atom Investors LP | 46,614 | $1,187,259 | 0.45% |
|---|
| AFFINITY INVESTMENT ADVISORS, LLC | 25,182 | $641,386 | 0.37% |
|---|
| Virtus Fund Advisers, LLC | 2,059 | $52,443 | 0.37% |
|---|
| FORMULA GROWTH LTD | 42,000 | $1,069,740 | 0.34% |
|---|
| Eventide Asset Management | 732,000 | $18,644,040 | 0.32% |
|---|
| PDT Partners, LLC | 87,711 | $2,233,999 | 0.31% |
|---|
| Champlain Investment Partners, LLC | 1,922,345 | $48,962,127 | 0.30% |
|---|
| GW&K Investment Management, LLC | 1,136,026 | $28,935 | 0.28% |
|---|