| Darwin Global Management, Ltd. | 9,278,439 | $230,476,425 | 37.68% |
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| Ghost Tree Capital, LLC | 825,000 | $20,493,000 | 6.76% |
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| M28 Capital Management LP | 142,500 | $3,539,700 | 4.68% |
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| Ikarian Capital, LLC | 826,100 | $20,520,324 | 3.27% |
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| Ikarian Capital, LLC | 826,100 | $20,520,324 | 3.27% |
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| Spotlight Asset Group, Inc. | 75,000 | $1,863,000 | 1.67% |
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| Soleus Capital Management, L.P. | 435,500 | $10,817,820 | 1.20% |
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| Parkman Healthcare Partners LLC | 220,634 | $5,480,549 | 0.95% |
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| Pier Capital, LLC | 234,318 | $5,820,459 | 0.84% |
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| Integral Health Asset Management, LLC | 250,000 | $6,210,000 | 0.77% |
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| Quantum Private Wealth, LLC | 62,228 | $1,545,744 | 0.71% |
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| Lisanti Capital Growth, LLC | 193,460 | $4,805,546 | 0.67% |
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| Harvest Investment Services, LLC | 44,471 | $1,104,660 | 0.63% |
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| Capital CS Group, LLC | 17,525 | $435,321 | 0.43% |
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| CLARK FINANCIAL SERVICES GROUP INC /BD | 12,335 | $306,401 | 0.41% |
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| EAM Investors, LLC | 84,552 | $2,100,272 | 0.39% |
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| MOODY ALDRICH PARTNERS LLC | 77,278 | $1,919,586 | 0.37% |
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| Hillsdale Investment Management Inc. | 156,730 | $3,893,173 | 0.36% |
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| AVAII WEALTH MANAGEMENT, LLC | 18,554 | $460,882 | 0.35% |
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| PREVAIL INNOVATIVE WEALTH ADVISORS, LLC | 21,500 | $534,060 | 0.29% |
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