| CAXTON CORP | 1,318,967 | $5,671,558 | 28.74% |
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| Altium Capital Management LP | 1,700,000 | $7,310,000 | 2.98% |
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| Velan Capital Investment Management LP | 800,000 | $3,440,000 | 1.97% |
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| Ghost Tree Capital, LLC | 1,421,501 | $6,112,454 | 1.91% |
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| ADAR1 Capital Management, LLC | 2,063,962 | $8,875,037 | 1.68% |
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| Vivo Capital, LLC | 2,797,704 | $12,030,127 | 1.11% |
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| Exome Asset Management LLC | 282,400 | $1,214,320 | 1.06% |
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| SPHERA FUNDS MANAGEMENT LTD. | 1,707,999 | $7,344,396 | 1.00% |
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| Affinity Asset Advisors, LLC | 1,850,000 | $7,955,000 | 0.92% |
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| Rosalind Advisors, Inc. | 250,000 | $1,075,000 | 0.83% |
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| Nantahala Capital Management | 2,989,963 | $12,856,841 | 0.76% |
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| Ikarian Capital, LLC | 903,744 | $3,886,099 | 0.68% |
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| Monashee Investment Management LLC | 250,000 | $1,075,000 | 0.14% |
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| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 457,737 | $1,968,269 | 0.12% |
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| FEDERATED HERMES, INC. | 11,279,327 | $48,501,106 | 0.12% |
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| EAM Investors, LLC | 129,858 | $558,389 | 0.09% |
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| Blackstone Inc. | 1,744,640 | $7,501,952 | 0.03% |
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| Alyeska Investment Group, L.P. | 1,089,767 | $4,685,998 | 0.03% |
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| PRELUDE CAPITAL MANAGEMENT, LLC | 87,900 | $377,970 | 0.03% |
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| BOOTHBAY FUND MANAGEMENT, LLC | 258,750 | $1,112,625 | 0.03% |
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