| Athyrium Capital Management, LP | 1,256,411 | $4,095,900 | 12.21% |
|---|
| GREAT POINT PARTNERS LLC | 1,486,544 | $4,846,133 | 0.93% |
|---|
| Frazier Life Sciences Management, L.P. | 3,062,558 | $9,983,939 | 0.47% |
|---|
| Eversept Partners, LP | 1,328,454 | $4,330,760 | 0.30% |
|---|
| GLOBEFLEX CAPITAL L P | 452,606 | $1,475,496 | 0.15% |
|---|
| Affinity Asset Advisors, LLC | 250,000 | $815,000 | 0.09% |
|---|
| OXFORD ASSET MANAGEMENT LLP | 21,007 | $68,483 | 0.08% |
|---|
| TANG CAPITAL MANAGEMENT LLC | 200,000 | $652,000 | 0.07% |
|---|
| WINTON GROUP Ltd | 300,599 | $979,953 | 0.07% |
|---|
| GSA CAPITAL PARTNERS LLP | 189,751 | $619 | 0.04% |
|---|
| RICE HALL JAMES & ASSOCIATES, LLC | 144,792 | $472,022 | 0.03% |
|---|
| Alpine Global Management, LLC | 40,116 | $130,778 | 0.02% |
|---|
| ACADIAN ASSET MANAGEMENT LLC | 1,951,208 | $6,356 | 0.02% |
|---|
| XTX Topco Ltd | 48,611 | $158,472 | 0.01% |
|---|
| Prospera Financial Services Inc | 149,570 | $487,588 | 0.01% |
|---|
| State of Wyoming | 26,963 | $87,899 | 0.01% |
|---|
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 139,400 | $454,444 | 0.01% |
|---|
| Renaissance Technologies | 1,753,013 | $5,714,822 | 0.01% |
|---|
| Schonfeld Strategic Advisors LLC | 334,107 | $1,089,188 | 0.01% |
|---|
| Patriot Financial Group Insurance Agency, LLC | 11,000 | $35,860 | 0.01% |
|---|