| RA Capital Management | 2,559,918 | $543,496,000 | 8.72% |
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| Foresite Capital Management I, LLC | 66,810 | $14,184,000 | 8.55% |
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| Samsara BioCapital, LLC | 198,600 | $42,165,000 | 5.20% |
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| DISCOVERY CAPITAL MANAGEMENT, LLC / CT | 330,541 | $70,177,000 | 4.54% |
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| Foresite Capital Management II, LLC | 67,373 | $14,304,000 | 3.85% |
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| Rock Springs Capital Management LP | 455,000 | $96,601,000 | 1.91% |
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| DELTEC ASSET MANAGEMENT LLC | 56,320 | $11,957,000 | 1.65% |
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| Parametrica Management Ltd | 10,200 | $2,166,000 | 1.60% |
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| SECTORAL ASSET MANAGEMENT INC | 88,450 | $18,779,000 | 1.52% |
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| TSP Capital Management Group, LLC | 18,525 | $3,933,000 | 1.29% |
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| Lombard Odier Asset Management (Switzerland) SA | 109,423 | $23,232,000 | 1.18% |
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| Carmignac Gestion | 457,805 | $97,194,000 | 1.13% |
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| Foresite Capital Management III, LLC | 5,000 | $1,062,000 | 1.13% |
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| ACT CAPITAL MANAGEMENT, LLC | 10,300 | $2,187,000 | 1.12% |
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| SevenOneSeven Capital Management | 1,977 | $420,000 | 1.09% |
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| CSS LLC/IL | 123,500 | $26,220,000 | 1.09% |
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| Sargent Investment Group, LLC | 20,647 | $4,384,000 | 1.04% |
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| PFM Health Sciences, LP | 149,104 | $31,656,000 | 0.99% |
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| TOBAM | 106,947 | $22,706,000 | 0.91% |
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| Avenir Corp | 49,614 | $10,534,000 | 0.84% |
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