| JANUS HENDERSON GROUP PLC | 2,601,282 | $694,526,099 | 0.38% |
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| PFM Health Sciences, LP | 29,973 | $8,003,990 | 0.38% |
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| Simplify Asset Management Inc. | 23,294 | $6,220,430 | 0.37% |
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| Cutler Group LLC / CA | 36,900 | $1,092 | 0.36% |
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| Knott David M Jr | 3,584 | $957 | 0.34% |
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| FNY Investment Advisers, LLC | 2,075 | $554 | 0.33% |
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| Sofinnova Investments, Inc. | 19,029 | $5,081,504 | 0.28% |
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| Cutler Group LLC / CA | 32,000 | $763 | 0.25% |
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| HighVista Strategies LLC | 2,534 | $676,679 | 0.24% |
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| Verity Asset Management, Inc. | 1,574 | $420,321 | 0.23% |
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| MOODY ALDRICH PARTNERS LLC | 5,124 | $1,368,313 | 0.23% |
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| JGP Global Gestao de Recursos Ltda. | 1,333 | $355,964 | 0.23% |
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| Polar Capital Holdings Plc | 125,205 | $33,434,743 | 0.18% |
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| JOURNEY STRATEGIC WEALTH LLC | 13,320 | $3,556,973 | 0.16% |
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| Artisan Partners Limited Partnership | 401,709 | $107,272,371 | 0.16% |
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| Congress Park Capital LLC | 1,200 | $320,448 | 0.14% |
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| DRIEHAUS CAPITAL MANAGEMENT LLC | 50,709 | $13,541,331 | 0.14% |
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| AMI ASSET MANAGEMENT CORP | 9,618 | $2,568,476 | 0.13% |
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| GILDER GAGNON HOWE & CO LLC | 39,083 | $10,436,724 | 0.13% |
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| China Universal Asset Management Co., Ltd. | 3,801 | $1,015,019 | 0.13% |
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