| Artal Group S.A. | 117,553,284 | $128,133 | 5.49% |
|---|
| BVF INC/IL | 19,995,332 | $21,794,912 | 0.59% |
|---|
| Octagon Capital Advisors LP | 1,923,076 | $2,096,153 | 0.32% |
|---|
| Parkman Healthcare Partners LLC | 1,136,413 | $1,238,690 | 0.23% |
|---|
| NEA Management Company, LLC | 2,382,286 | $2,596,692 | 0.20% |
|---|
| Virtus ETF Advisers LLC | 121,711 | $132,665 | 0.08% |
|---|
| PINNACLE ASSOCIATES LTD | 1,912,869 | $2,085,027 | 0.04% |
|---|
| Prosperity Financial Group, Inc. | 31,500 | $34,335 | 0.03% |
|---|
| UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO | 35,714 | $39 | 0.02% |
|---|
| ClariVest Asset Management LLC | 192,398 | $210 | 0.01% |
|---|
| LifeSteps Financial, Inc. | 10,000 | $10,900 | 0.01% |
|---|
| Covestor Ltd | 8,385 | $9 | 0.01% |
|---|
| Hudson Capital Management LLC | 15,038 | $16,391 | 0.01% |
|---|
| Alyeska Investment Group, L.P. | 509,484 | $555,338 | 0.00% |
|---|
| Chemistry Wealth Management LLC | 12,000 | $13,080 | 0.00% |
|---|
| Schonfeld Strategic Advisors LLC | 469,666 | $511,935 | 0.00% |
|---|
| Traynor Capital Management, Inc. | 21,909 | $23,880 | 0.00% |
|---|
| Pinnacle Wealth Management Advisory Group, LLC | 12,135 | $13,227 | 0.00% |
|---|
| TWO SIGMA INVESTMENTS, LP | 645,368 | $703,451 | 0.00% |
|---|
| Estabrook Capital Management | 10,000 | $10,900 | 0.00% |
|---|