| SC 13G/A | 2017-02-14 | BB BIOTECH AG | IONIS PHARMACEUTICALS INC | 6,913,172 | 5.7% | EDGAR |
| SC 13G/A | 2017-02-13 | VANGUARD GROUP INC | IONIS PHARMACEUTICALS INC | 9,052,966 | 7.5% | EDGAR |
| SC 13G | 2017-01-30 | BlackRock Inc. | IONIS PHARMACEUTICALS INC | 6,457,810 | 5.3% | EDGAR |
| SC 13G/A | 2017-01-27 | BAILLIE GIFFORD & CO | IONIS PHARMACEUTICALS INC | 8,415,156 | 6.9% | EDGAR |
| SC 13G/A | 2016-12-12 | Clearbridge Investments, LLC | IONIS PHARMACEUTICALS INC | 12,301,825 | 10.2% | EDGAR |
| SC 13G/A | 2016-09-09 | BlackRock Inc. | IONIS PHARMACEUTICALS INC | 6,034,750 | 5.0% | EDGAR |
| SC 13G/A | 2016-02-16 | Clearbridge Investments, LLC | IONIS PHARMACEUTICALS INC | 9,474,704 | 7.9% | EDGAR |
| SC 13G/A | 2016-02-12 | FMR LLC | IONIS PHARMACEUTICALS INC | 18,071,779 | 15.0% | EDGAR |
| SC 13G/A | 2016-02-10 | BlackRock Inc. | IONIS PHARMACEUTICALS INC | 8,182,073 | 6.8% | EDGAR |
| SC 13G/A | 2016-02-10 | VANGUARD GROUP INC | IONIS PHARMACEUTICALS INC | 8,250,750 | 6.9% | EDGAR |
| SC 13G/A | 2016-02-09 | BB BIOTECH AG | IONIS PHARMACEUTICALS INC | 6,529,838 | 5.4% | EDGAR |
| SC 13G | 2016-02-05 | BAILLIE GIFFORD & CO | IONIS PHARMACEUTICALS INC | 8,078,158 | 6.7% | EDGAR |
| SC 13D/A | 2015-07-31 | ISIS PHARMACEUTICALS INC | Regulus Therapeutics Inc. | 2,843,172 | 5.6% | EDGAR |
| SC 13G/A | 2015-02-17 | Clearbridge Investments, LLC | ISIS PHARMACEUTICALS INC | 9,034,520 | 7.6% | EDGAR |
| SC 13G/A | 2015-02-13 | FMR LLC | ISIS PHARMACEUTICALS INC | 17,892,555 | 15.1% | EDGAR |
| SC 13G/A | 2015-02-12 | BB BIOTECH AG | ISIS PHARMACEUTICALS INC | 5,976,526 | 5.1% | EDGAR |
| SC 13G/A | 2015-02-10 | VANGUARD GROUP INC | ISIS PHARMACEUTICALS INC | 7,271,871 | 6.2% | EDGAR |
| SC 13G/A | 2015-01-30 | Artisan Partners Limited Partnership | ISIS PHARMACEUTICALS INC | 3,852,643 | 3.3% | EDGAR |
| SC 13G/A | 2015-01-23 | BlackRock Inc. | ISIS PHARMACEUTICALS INC | 9,541,651 | 8.1% | EDGAR |
| SC 13D/A | 2014-11-06 | ISIS PHARMACEUTICALS INC | Regulus Therapeutics Inc. | 5,541,305 | 11.4% | EDGAR |