| FRONTIER CAPITAL MANAGEMENT CO LLC | 406,879 | $132,089,199 | 1.27% |
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| OAK RIDGE INVESTMENTS LLC | 29,922 | $9,713,878 | 1.20% |
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| WESTFIELD CAPITAL MANAGEMENT CO LP | 563,667 | $182,988,855 | 1.16% |
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| Champlain Investment Partners, LLC | 566,115 | $183,783,574 | 1.13% |
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| NEXT CENTURY GROWTH INVESTORS LLC | 32,862 | $10,668,319 | 1.03% |
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| WASATCH ADVISORS LP | 496,287 | $161,114,612 | 0.98% |
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| Miura Global Management | 8,000 | $2,597,120 | 0.93% |
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| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 836,162 | $271,451,632 | 0.87% |
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| Novo Holdings A/S | 32,500 | $10,550,800 | 0.82% |
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| Parkman Healthcare Partners LLC | 14,470 | $4,697,541 | 0.81% |
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| Aquatic Capital Management LLC | 46,300 | $15,031 | 0.81% |
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| FRED ALGER MANAGEMENT, LLC | 467,378 | $151,729,594 | 0.78% |
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| Ergoteles LLC | 43,753 | $14,203,974 | 0.68% |
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| Eventide Asset Management | 108,220 | $35,132,541 | 0.59% |
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| EFG Asset Management (North America) Corp. | 8,121 | $2,635,386 | 0.56% |
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| FARALLON CAPITAL MANAGEMENT LLC | 323,096 | $104,889,885 | 0.54% |
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| Rhenman & Partners Asset Management AB | 15,400 | $4,999,456 | 0.53% |
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| AFFINITY INVESTMENT ADVISORS, LLC | 2,776 | $901,201 | 0.52% |
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| LORD, ABBETT & CO. LLC | 450,539 | $146,263 | 0.50% |
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| KORNITZER CAPITAL MANAGEMENT INC /KS | 76,075 | $24,696,988 | 0.49% |
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