| INTERWEST VENTURE MANAGEMENT CO | 16,347 | $1,230,112 | 5.96% |
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| Iron Triangle Partners LP | 430,000 | $32,357,500 | 4.73% |
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| PURA VIDA INVESTMENTS, LLC | 316,661 | $23,828,740 | 4.51% |
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| Brown Capital Management | 2,608,374 | $196,280,144 | 3.01% |
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| Taylor Frigon Capital Management LLC | 51,567 | $3,880,417 | 2.16% |
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| Atika Capital Management LLC | 215,200 | $16,193,800 | 2.12% |
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| BRAIDWELL LP | 695,792 | $52,358,348 | 1.66% |
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| Tri Locum Partners LP | 56,230 | $4,231,308 | 1.35% |
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| MONEY CONCEPTS CAPITAL CORP | 160,094 | $12,047,389 | 1.26% |
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| SECTORAL ASSET MANAGEMENT INC | 69,000 | $5,192,250 | 1.01% |
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| Lisanti Capital Growth, LLC | 84,605 | $6,366,526 | 1.01% |
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| EAM Global Investors LLC | 48,890 | $3,678,973 | 1.00% |
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| FRED ALGER MANAGEMENT, LLC | 1,780,690 | $133,996,922 | 0.77% |
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| RIVERBRIDGE PARTNERS LLC | 551,288 | $41,484,444 | 0.60% |
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| Rhenman & Partners Asset Management AB | 73,000 | $5,493,250 | 0.59% |
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| EFG Asset Management (North America) Corp. | 28,648 | $2,154,903 | 0.51% |
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| DRIEHAUS CAPITAL MANAGEMENT LLC | 489,565 | $36,839,766 | 0.48% |
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| Polar Asset Management Partners Inc. | 286,108 | $21,529,627 | 0.48% |
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| EAM Investors, LLC | 25,145 | $1,892,161 | 0.36% |
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| HARBOR CAPITAL ADVISORS, INC. | 20,384 | $1,533,896 | 0.33% |
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