| SUPERSTRING CAPITAL MANAGEMENT LP | 680,403 | $5,450,028 | 6.87% |
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| University of Wisconsin Foundation | 724,132 | $5,800,297 | 6.53% |
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| SUVRETTA CAPITAL MANAGEMENT, LLC | 8,031,845 | $64,335,078 | 2.36% |
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| Orchard Capital Management, LLC | 739,208 | $5,921,056 | 1.79% |
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| BVF INC/IL | 7,568,479 | $60,623,517 | 1.70% |
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| RA Capital Management | 14,175,398 | $113,544,938 | 1.50% |
|---|
| MPM BioImpact LLC | 1,121,736 | $8,985,105 | 1.40% |
|---|
| RTW INVESTMENTS, LP | 7,378,548 | $59,102,169 | 0.92% |
|---|
| Redmile Group, LLC | 1,745,656 | $13,982,705 | 0.84% |
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| SPHERA FUNDS MANAGEMENT LTD. | 526,547 | $4,217,641 | 0.58% |
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| Deep Track Capital, LP | 2,294,011 | $18,375,028 | 0.55% |
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| Frazier Life Sciences Management, L.P. | 1,000,000 | $8,010,000 | 0.38% |
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| Newtyn Management, LLC | 240,000 | $1,922,400 | 0.36% |
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| Integral Health Asset Management, LLC | 450,000 | $3,604,500 | 0.34% |
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| Laurion Capital Management LP | 2,180,931 | $17,469,257 | 0.21% |
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| SILVERARC CAPITAL MANAGEMENT, LLC | 92,298 | $739,307 | 0.17% |
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| Pennant Investors, LP | 44,500 | $356,445 | 0.09% |
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| WESTFIELD CAPITAL MANAGEMENT CO LP | 2,319,365 | $18,578,114 | 0.09% |
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| Sandia Investment Management LP | 8,786 | $70,376 | 0.09% |
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| Gilliland Jeter Wealth Management LLC | 32,376 | $259,332 | 0.09% |
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