| Nantahala Capital Management | 5,035,663 | $14,099,856 | 1.36% |
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| Telemark Asset Management, LLC | 2,544,500 | $7,124,600 | 0.97% |
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| Trellus Management Company, LLC | 251,460 | $704,088 | 0.87% |
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| JACOB ASSET MANAGEMENT OF NEW YORK LLC | 198,471 | $555,719 | 0.63% |
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| Opaleye Management Inc. | 675,000 | $1,890,000 | 0.45% |
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| WHITE PINE CAPITAL LLC | 249,477 | $698,536 | 0.26% |
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| Empire Financial Management Company, LLC | 126,000 | $352,800 | 0.14% |
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| Nebula Research & Development LLC | 39,194 | $109,743 | 0.08% |
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| ARK Investment Management | 4,124,339 | $11,548,150 | 0.08% |
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| Vivo Capital, LLC | 388,144 | $1,086,803 | 0.08% |
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| XTX Topco Ltd | 104,311 | $292,071 | 0.05% |
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| PARADIGM CAPITAL MANAGEMENT INC/NY | 300,000 | $840,000 | 0.05% |
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| Inspire Investing, LLC | 112,213 | $314,196 | 0.04% |
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| PDT Partners, LLC | 90,080 | $252,224 | 0.04% |
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| Nikko Asset Management Americas, Inc. | 1,124,015 | $3,136,002 | 0.03% |
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| Engineers Gate Manager LP | 263,636 | $738,181 | 0.03% |
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| EXCHANGE TRADED CONCEPTS, LLC | 400,128 | $1,120,358 | 0.03% |
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| State of Wyoming | 31,836 | $89,141 | 0.03% |
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| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,282,594 | $3,591,263 | 0.02% |
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| FEDERATED HERMES, INC. | 2,525,065 | $7,070,182 | 0.02% |
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