| Opaleye Management Inc. | 3,455,000 | $10,710,500 | 2.45% |
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| Kent Lake Capital LLC | 1,300,000 | $4,030,000 | 1.82% |
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| Telemark Asset Management, LLC | 2,696,411 | $8,358,874 | 0.73% |
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| Nantahala Capital Management | 3,629,622 | $11,251,828 | 0.66% |
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| Casdin Capital, LLC | 2,000,000 | $6,200,000 | 0.48% |
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| PERKINS CAPITAL MANAGEMENT INC | 159,600 | $495 | 0.47% |
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| Empire Financial Management Company, LLC | 212,952 | $660,151 | 0.22% |
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| WHITE PINE CAPITAL LLC | 117,944 | $365,626 | 0.14% |
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| PARADIGM CAPITAL MANAGEMENT INC/NY | 900,000 | $2,790,000 | 0.13% |
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| PRESCOTT GROUP CAPITAL MANAGEMENT, L.L.C. | 237,174 | $735,000 | 0.12% |
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| Vivo Capital, LLC | 388,144 | $1,203,246 | 0.11% |
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| PLATINUM INVESTMENT MANAGEMENT LTD | 200,063 | $620,195 | 0.02% |
|---|
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 242,000 | $750,200 | 0.02% |
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| Elmwood Wealth Management, Inc. | 10,350 | $32,085 | 0.01% |
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| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,009,889 | $3,130,656 | 0.01% |
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| GSA CAPITAL PARTNERS LLP | 54,292 | $168 | 0.01% |
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| FEDERATED HERMES, INC. | 1,254,465 | $3,888,842 | 0.01% |
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| Engineers Gate Manager LP | 107,891 | $334,462 | 0.01% |
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| Baillie Gifford | 2,708,802 | $8,397,286 | 0.01% |
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| Assenagon Asset Management S.A. | 894,235 | $2,772,129 | 0.01% |
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