| SILVERARC CAPITAL MANAGEMENT, LLC | 1,465,744 | $2,579,709 | 0.61% |
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| Senvest Management, LLC | 7,277,502 | $12,808,404 | 0.49% |
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| Baker Brothers Advisors | 19,477,339 | $34,280,117 | 0.44% |
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| ARK Investment Management | 19,900,184 | $35,024,324 | 0.31% |
|---|
| Sepio Capital, LP | 1,347,500 | $2,372,000 | 0.22% |
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| Bouvel Investment Partners, LLC | 269,938 | $475,091 | 0.18% |
|---|
| GSA CAPITAL PARTNERS LLP | 1,465,022 | $2,578 | 0.18% |
|---|
| Nikko Asset Management Americas, Inc. | 7,498,240 | $13,121,920 | 0.15% |
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| WASATCH ADVISORS LP | 7,385,293 | $12,998,116 | 0.07% |
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| Hood River Capital Management LLC | 1,469,754 | $2,586,767 | 0.05% |
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| IEQ CAPITAL, LLC | 2,142,739 | $3,771,221 | 0.05% |
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| State of Wyoming | 122,262 | $215,181 | 0.04% |
|---|
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 2,732,471 | $4,809,149 | 0.03% |
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| JGP Global Gestao de Recursos Ltda. | 14,539 | $25,589 | 0.03% |
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| XTX Topco Ltd | 150,368 | $264,648 | 0.02% |
|---|
| Whitegate Investment Counselors, Inc. | 29,049 | $51,126 | 0.02% |
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| PRIMECAP MANAGEMENT CO/CA/ | 8,584,000 | $15,107,840 | 0.01% |
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| Sumitomo Mitsui Trust Holdings, Inc. | 7,498,240 | $13,196,902 | 0.01% |
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| Beirne Wealth Consulting Services, LLC | 11,000 | $19,360 | 0.01% |
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| Engineers Gate Manager LP | 186,558 | $328,342 | 0.01% |
|---|