| Blue Water Life Science Advisors, LP | 510,000 | $7,920,300 | 7.70% |
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| GAGNON SECURITIES LLC | 2,174,167 | $33,764,820 | 7.60% |
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| Gagnon Advisors, LLC | 610,336 | $9,478,518 | 7.22% |
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| Bullseye Asset Management LLC | 184,820 | $2,871 | 1.41% |
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| Bellevue Group AG | 3,912,575 | $60,762,290 | 0.99% |
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| ARK Investment Management | 5,702,351 | $88,557,507 | 0.79% |
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| Virtus Investment Advisers, Inc. | 55,145 | $856,402 | 0.72% |
|---|
| Nikko Asset Management Americas, Inc. | 2,576,261 | $39,957,808 | 0.46% |
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| Jackson Creek Investment Advisors LLC | 75,584 | $1,174 | 0.43% |
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| Intrinsic Edge Capital Management LLC | 190,000 | $2,950,700 | 0.27% |
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| Corton Capital Inc. | 29,550 | $458,912 | 0.24% |
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| THOMPSON DAVIS & CO., INC. | 17,825 | $276,822 | 0.24% |
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| OBERWEIS ASSET MANAGEMENT INC/ | 250,400 | $3,888,712 | 0.24% |
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| Virtus Fund Advisers, LLC | 3,456 | $53,672 | 0.21% |
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| Bradley & Co. Private Wealth Management, LLC | 14,087 | $218,771 | 0.16% |
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| ARS Investment Partners, LLC | 81,435 | $1,264,686 | 0.12% |
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| Cetera Trust Company, N.A | 11,870 | $184,341 | 0.12% |
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| ClariVest Asset Management LLC | 64,027 | $994,339 | 0.10% |
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| FRED ALGER MANAGEMENT, LLC | 1,149,602 | $17,853,319 | 0.09% |
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| BAMCO INC /NY/ | 1,876,672 | $29,144,716 | 0.08% |
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