| Aquilo Capital Management, LLC | 448,987 | $28,375,978 | 15.72% |
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| DAFNA Capital Management LLC | 251,521 | $15,896,127 | 4.35% |
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| Casdin Capital, LLC | 620,000 | $39,184,000 | 3.42% |
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| Rock Springs Capital Management LP | 2,186,672 | $138,197,670 | 3.29% |
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| EcoR1 Capital, LLC | 1,798,300 | $113,652,560 | 2.78% |
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| Novo Holdings A/S | 448,804 | $28,364,413 | 2.19% |
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| ORACLE INVESTMENT MANAGEMENT INC | 41,377 | $2,615,026 | 1.93% |
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| SECTORAL ASSET MANAGEMENT INC | 136,837 | $8,648,098 | 1.44% |
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| EMERALD MUTUAL FUND ADVISERS TRUST | 413,327 | $26,122,266 | 1.42% |
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| EMERALD ADVISERS, LLC | 496,053 | $31,350,550 | 1.37% |
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| EFG Asset Management (North America) Corp. | 90,124 | $5,693,133 | 1.22% |
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| Avidity Partners Management LP | 415,000 | $26,228,000 | 0.92% |
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| NBW CAPITAL LLC | 52,540 | $3,320,528 | 0.78% |
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| Capital Impact Advisors, LLC | 10,676 | $674,723 | 0.74% |
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| Hood River Capital Management LLC | 273,449 | $17,282,000 | 0.51% |
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| Eventide Asset Management | 438,500 | $27,713,200 | 0.47% |
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| Granahan Investment Management | 184,503 | $11,660,590 | 0.36% |
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| HARBOR CAPITAL ADVISORS, INC. | 24,353 | $1,539,110 | 0.31% |
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| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 1,474,490 | $93,187,768 | 0.30% |
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| TORRAY INVESTMENT PARTNERS LLC | 23,740 | $1,500,368 | 0.26% |
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