| Soleus Capital Management, L.P. | 3,785,829 | $18,929,145 | 1.75% |
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| PERKINS CAPITAL MANAGEMENT INC | 301,340 | $1,507 | 1.49% |
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| DAFNA Capital Management LLC | 935,894 | $4,679,470 | 1.46% |
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| First Light Asset Management, LLC | 1,925,132 | $9,625,660 | 0.91% |
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| Birchview Capital, LP | 173,000 | $865,000 | 0.74% |
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| ArrowMark Colorado Holdings LLC | 4,554,880 | $22,774,400 | 0.28% |
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| ESSEX INVESTMENT MANAGEMENT CO LLC | 296,440 | $1,482,200 | 0.24% |
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| Perceptive Advisors | 875,898 | $4,379,490 | 0.15% |
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| Empire Financial Management Company, LLC | 60,000 | $300,000 | 0.13% |
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| WHITE PINE CAPITAL LLC | 47,433 | $237,165 | 0.10% |
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| TOCQUEVILLE ASSET MANAGEMENT L.P. | 934,900 | $4,674,500 | 0.09% |
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| Legato Capital Management LLC | 111,183 | $555,915 | 0.08% |
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| Granite Investment Partners, LLC | 351,007 | $1,755,035 | 0.07% |
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| KENNEDY CAPITAL MANAGEMENT LLC | 304,257 | $1,521,285 | 0.04% |
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| WRAPMANAGER INC | 23,320 | $116,600 | 0.04% |
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| SILVERCREST ASSET MANAGEMENT GROUP LLC | 921,986 | $4,609,930 | 0.04% |
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| XTX Topco Ltd | 36,228 | $181,140 | 0.03% |
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| UBS OCONNOR LLC | 239,196 | $1,195,980 | 0.03% |
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| HARBOR CAPITAL ADVISORS, INC. | 24,239 | $121,195 | 0.03% |
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| SHERBROOKE PARK ADVISERS LLC | 16,513 | $82,565 | 0.03% |
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