| Eventide Asset Management | 329,076 | $128,250,789 | 2.17% |
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| Integral Health Asset Management, LLC | 40,000 | $15,589,200 | 1.93% |
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| Artisan Partners Limited Partnership | 3,038,383 | $1,184,149,007 | 1.90% |
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| Evolutionary Tree Capital Management, LLC | 3,821 | $1,489,158 | 1.79% |
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| SAL Trading, LLC | 4,000 | $1,558,920 | 1.74% |
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| PFM Health Sciences, LP | 104,732 | $40,817,202 | 1.58% |
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| Boxer Capital, LLC | 75,000 | $29,230 | 1.36% |
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| ARMISTICE CAPITAL, LLC | 200,000 | $77,946,000 | 1.13% |
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| Sofinnova Investments, Inc. | 39,921 | $15,558,411 | 1.02% |
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| Tekla Capital Management LLC | 65,553 | $25,547,971 | 1.00% |
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| Atika Capital Management LLC | 24,695 | $9,624,383 | 0.96% |
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| EFG Asset Management (North America) Corp. | 11,504 | $4,480,175 | 0.96% |
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| Monashee Investment Management LLC | 10,000 | $3,897,300 | 0.93% |
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| Saturn V Capital Management LP | 4,081 | $1,590,488 | 0.88% |
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| Endurant Capital Management LP | 2,565 | $999,657 | 0.87% |
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| Sassicaia Capital Advisers LLC | 2,500 | $974,325 | 0.83% |
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| Susquehanna International Securities, Ltd. | 2,170 | $845,714 | 0.79% |
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| Perceptive Advisors | 69,000 | $26,891,370 | 0.78% |
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| QVT Financial LP | 32,498 | $12,665,446 | 0.69% |
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| Dorsey Wright & Associates | 5,900 | $2,298,937 | 0.69% |
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