| INTERNATIONAL BIOTECHNOLOGY TRUST PLC | 66,746 | $32,565 | 7.34% |
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| Forum Financial Management, LP | 473,072 | $114,398 | 5.52% |
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| O'Keefe Stevens Advisory, Inc. | 46,643 | $11,279 | 5.50% |
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| Smead Capital Management, Inc. | 965,991 | $233,596 | 5.42% |
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| JMAC ENTERPRISES LLC | 94,495 | $22,851 | 5.38% |
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| Tekla Capital Management LLC | 574,918 | $139,027 | 4.88% |
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| ABSHER WEALTH MANAGEMENT, LLC | 111,135 | $26,875 | 4.59% |
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| EDMP, INC. | 17,663 | $4,271 | 4.01% |
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| Birch Capital Management, LLC | 22,398 | $5,416 | 3.33% |
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| Sarasin & Partners LLP | 1,363,607 | $329,747 | 3.32% |
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| Coho Partners, Ltd. | 826,302 | $199,816 | 3.29% |
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| HUNTER ASSOCIATES INVESTMENT MANAGEMENT LLC | 42,055 | $10,170 | 3.27% |
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| Ikarian Capital, LLC | 100,000 | $24,182 | 3.18% |
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| MONTRUSCO BOLTON INVESTMENTS INC. | 566,273 | $134,884 | 3.11% |
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| VAN STRUM & TOWNE INC. | 34,112 | $8,249 | 3.09% |
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| EDGAR LOMAX CO/VA | 215,545 | $52,123 | 3.06% |
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| Cornerstone Capital, Inc. | 111,675 | $27,005 | 3.03% |
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| OLD POINT TRUST & FINANCIAL SERVICES N A | 30,235 | $7,311 | 2.99% |
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| GUARDIAN INVESTMENT MANAGEMENT | 15,587 | $3,769 | 2.93% |
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| London & Capital Asset Management Ltd | 163,695 | $39,585 | 2.92% |
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