| MPM ASSET MANAGEMENT LLC | 6,287,101 | $5,815,569 | 2.85% |
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| Syncona Portfolio Ltd | 1,377,294 | $1,273,997 | 1.92% |
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| NEA Management Company, LLC | 17,079,778 | $15,798,795 | 1.21% |
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| MPM BioImpact LLC | 5,095,912 | $4,713,719 | 0.95% |
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| TANG CAPITAL MANAGEMENT LLC | 4,887,238 | $4,520,695 | 0.67% |
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| Endurant Capital Management LP | 821,038 | $759,460 | 0.66% |
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| Matrix Capital Management Company, LP | 38,974,185 | $36,051,121 | 0.42% |
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| Long Focus Capital Management, LLC | 7,812,528 | $7,226,588 | 0.33% |
|---|
| PFM Health Sciences, LP | 8,357,242 | $7,730,449 | 0.30% |
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| Key Client Fiduciary Advisors, LLC | 329,155 | $304,468 | 0.18% |
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| DAFNA Capital Management LLC | 351,064 | $324,734 | 0.09% |
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| Rock Springs Capital Management LP | 2,787,845 | $2,578,757 | 0.06% |
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| Baker Brothers Advisors | 10,969,282 | $10,146,586 | 0.06% |
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| Black Maple Capital Management LP | 69,839 | $64,601 | 0.04% |
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| Artal Group S.A. | 1,133,775 | $1,049 | 0.03% |
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| Diametric Capital, LP | 78,441 | $72,558 | 0.03% |
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| Redmile Group, LLC | 715,607 | $661,936 | 0.02% |
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| HARBOR CAPITAL ADVISORS, INC. | 112,516 | $104,077 | 0.02% |
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| Prosperity Wealth Management, Inc. | 30,620 | $28,324 | 0.02% |
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| Simplify Asset Management Inc. | 150,000 | $138,750 | 0.02% |
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