| Parkman Healthcare Partners LLC | 100,000 | $2,395,000 | 0.42% |
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| JUPITER ASSET MANAGEMENT LTD | 1,271,284 | $30,447,252 | 0.33% |
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| PDT Partners, LLC | 97,505 | $2,335,245 | 0.32% |
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| HighVista Strategies LLC | 28,791 | $689,544 | 0.32% |
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| Empire Life Investments Inc. | 177,062 | $4,240,635 | 0.29% |
|---|
| JGP Global Gestao de Recursos Ltda. | 16,368 | $392,014 | 0.27% |
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| FRED ALGER MANAGEMENT, LLC | 2,241,065 | $53,673,507 | 0.27% |
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| HUSSMAN STRATEGIC ADVISORS, INC. | 62,000 | $1,484,900 | 0.27% |
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| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,836,018 | $43,972,631 | 0.25% |
|---|
| Hillsdale Investment Management Inc. | 111,128 | $2,661,516 | 0.24% |
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| Woodline Partners LP | 830,355 | $19,887,002 | 0.24% |
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| Hennion & Walsh Asset Management, Inc. | 151,107 | $3,619 | 0.22% |
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| SEVEN EIGHT CAPITAL, LP | 53,724 | $1,286,690 | 0.21% |
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| Virtus ETF Advisers LLC | 14,235 | $340,928 | 0.20% |
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| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,553,093 | $85,096,577 | 0.18% |
|---|
| Edgestream Partners, L.P. | 84,170 | $2,015,871 | 0.18% |
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| Soleus Capital Management, L.P. | 66,000 | $1,580,700 | 0.18% |
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| GARRISON POINT ADVISORS, LLC | 10,020 | $239,979 | 0.17% |
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| Profit Investment Management, LLC | 10,829 | $259,354 | 0.17% |
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| FRONTIER CAPITAL MANAGEMENT CO LLC | 649,710 | $15,560,555 | 0.15% |
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