| Genesis Investment Management, LLP | 1,032,166 | $25,091,955 | 3.50% |
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| XY Capital Ltd | 139,743 | $3,397,152 | 1.95% |
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| Paradigm Biocapital Advisors LP | 1,142,383 | $27,771,331 | 1.88% |
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| Privium Fund Management B.V. | 240,683 | $5,851,004 | 1.74% |
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| Segantii Capital Management Ltd | 1,788,999 | $43,262,801 | 1.52% |
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| Vivo Capital, LLC | 454,606 | $11,051,472 | 1.21% |
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| BRILLIANCE ASSET MANAGEMENT LTD | 157,085 | $3,818,736 | 0.96% |
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| Capricorn Fund Managers Ltd | 100,967 | $2,454,508 | 0.85% |
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| Rock Springs Capital Management LP | 1,237,023 | $30,072,029 | 0.81% |
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| Long Corridor Asset Management Ltd | 31,000 | $753,610 | 0.66% |
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| INTERNATIONAL BIOTECHNOLOGY TRUST PLC | 78,958 | $1,917,890 | 0.65% |
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| Taikang Asset Management (Hong Kong) Co Ltd | 94,500 | $17,992 | 0.52% |
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| Triatomic Management LP | 17,000 | $413,270 | 0.29% |
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| VIKING GLOBAL INVESTORS LP | 2,491,003 | $60,556,283 | 0.25% |
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| Woodline Partners LP | 801,394 | $19,481,888 | 0.23% |
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| WealthPlan Investment Management, LLC | 39,393 | $957,644 | 0.17% |
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| Virtus ETF Advisers LLC | 10,998 | $267,361 | 0.16% |
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| BAMCO INC /NY/ | 1,579,349 | $38,393,974 | 0.11% |
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| Atika Capital Management LLC | 32,000 | $777,920 | 0.10% |
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| LANSDOWNE PARTNERS (UK) LLP | 35,142 | $854,302 | 0.08% |
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