| NEXT CENTURY GROWTH INVESTORS LLC | 1,537,271 | $38,723,856 | 4.26% |
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| Millrace Asset Group, Inc. | 72,595 | $1,829 | 2.13% |
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| Divisadero Street Capital Management, LP | 175,000 | $4,408,250 | 1.93% |
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| Perceptive Advisors | 2,442,250 | $61,520,278 | 1.82% |
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| SECTORAL ASSET MANAGEMENT INC | 366,443 | $9,230,699 | 1.77% |
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| EMERALD MUTUAL FUND ADVISERS TRUST | 1,120,875 | $28,234,841 | 1.67% |
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| EMERALD ADVISERS, LLC | 1,363,453 | $34,345,381 | 1.65% |
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| FORMULA GROWTH LTD | 124,900 | $3,146,231 | 1.01% |
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| Novo Holdings A/S | 540,000 | $13,602,600 | 0.90% |
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| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 755,379 | $19,027,997 | 0.78% |
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| Intrinsic Edge Capital Management LLC | 293,773 | $7,400,142 | 0.74% |
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| OBERWEIS ASSET MANAGEMENT INC/ | 154,300 | $3,886,817 | 0.60% |
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| OAK RIDGE INVESTMENTS LLC | 95,733 | $2,411,514 | 0.33% |
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| KORNITZER CAPITAL MANAGEMENT INC /KS | 634,223 | $15,976,077 | 0.32% |
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| TimesSquare Capital Management, LLC | 854,500 | $21,525 | 0.32% |
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| DRIEHAUS CAPITAL MANAGEMENT LLC | 752,190 | $18,947,666 | 0.27% |
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| PEREGRINE CAPITAL MANAGEMENT LLC | 280,178 | $7,057,684 | 0.20% |
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| CASTLEARK MANAGEMENT LLC | 129,250 | $3,255,808 | 0.16% |
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| Ghisallo Capital Management LLC | 25,000 | $629,750 | 0.15% |
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| PDT Partners, LLC | 39,129 | $985,660 | 0.13% |
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