| Avoro Capital Advisors LLC | 2,555,555 | $37,106,659 | 0.58% |
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| Frazier Life Sciences Management, L.P. | 600,000 | $8,712,000 | 0.58% |
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| Parkman Healthcare Partners LLC | 212,448 | $3,084,745 | 0.56% |
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| Sofinnova Investments, Inc. | 600,000 | $8,712,000 | 0.55% |
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| Ikarian Capital, LLC | 2,500 | $3,630,000 | 0.44% |
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| Sofinnova Investments, Inc. | 450,000 | $6,534,000 | 0.41% |
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| Orbimed Advisors | 1,284,000 | $18,643,680 | 0.40% |
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| ALGERT GLOBAL LLC | 456,219 | $6,624 | 0.31% |
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| Nantahala Capital Management | 240,031 | $3,485,250 | 0.30% |
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| Caption Management, LLC | 1,295,300 | $18,807,756 | 0.29% |
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| Nantahala Capital Management | 200,000 | $2,904,000 | 0.25% |
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| Crestline Management, LP | 134,464 | $1,952,417 | 0.23% |
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| Lion Point Capital, LP | 34,500 | $500,940 | 0.22% |
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| HighVista Strategies LLC | 29,490 | $428,195 | 0.20% |
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| OCCUDO QUANTITATIVE STRATEGIES LP | 88,208 | $1,280,780 | 0.17% |
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| Soleus Capital Management, L.P. | 119,500 | $1,735,140 | 0.16% |
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| Hudson Bay Capital Management LP | 2,472,372 | $35,898,842 | 0.14% |
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| Frazier Life Sciences Management, L.P. | 600,000 | $1,566,000 | 0.10% |
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| Caption Management, LLC | 430,800 | $6,255,216 | 0.10% |
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| PEREGRINE CAPITAL MANAGEMENT LLC | 219,974 | $3,194,022 | 0.10% |
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