| CPMG Inc | 5,328,867 | $174,840,126 | 95.60% |
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| JOHNSON & JOHNSON | 357,939 | $11,743,979 | 4.33% |
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| Frank, Rimerman Advisors LLC | 456,953 | $14,992,628 | 3.63% |
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| Eagle Health Investments LP | 337,218 | $11,064,123 | 2.44% |
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| Taylor Frigon Capital Management LLC | 124,462 | $4,083,598 | 2.27% |
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| Evolutionary Tree Capital Management, LLC | 49,060 | $1,609,659 | 2.08% |
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| Rhenman & Partners Asset Management AB | 493,000 | $16,175,330 | 1.74% |
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| AtonRa Partners | 16,462 | $540,118 | 1.13% |
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| Point72 Europe (London) LLP | 406,271 | $13,329,752 | 0.82% |
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| SANDLER CAPITAL MANAGEMENT | 211,200 | $6,929,472 | 0.71% |
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| DAFNA Capital Management LLC | 67,300 | $2,208,113 | 0.69% |
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| AlphaCentric Advisors LLC | 30,000 | $984,300 | 0.56% |
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| Bellevue Group AG | 888,296 | $29,144,992 | 0.47% |
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| NEXT CENTURY GROWTH INVESTORS LLC | 129,468 | $4,247,845 | 0.46% |
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| LYELL WEALTH MANAGEMENT, LP | 95,888 | $3,146,085 | 0.42% |
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| Monashee Investment Management LLC | 25,693 | $842,987 | 0.35% |
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| BRAIDWELL LP | 331,061 | $10,862,111 | 0.34% |
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| Polar Asset Management Partners Inc. | 463,259 | $15,199,528 | 0.34% |
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| Champlain Investment Partners, LLC | 1,568,394 | $51,459,007 | 0.33% |
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| ESSEX INVESTMENT MANAGEMENT CO LLC | 60,034 | $1,969,716 | 0.32% |
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