| RTW INVESTMENTS, LP | 673,371 | $162,895,179 | 3.44% |
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| Rock Springs Capital Management LP | 503,750 | $121,862,163 | 3.26% |
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| OAK HARBOR WEALTH PARTNERS, LLC | 34,357 | $8,311,302 | 2.94% |
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| CARRET ASSET MANAGEMENT, LLC | 79,000 | $19,110,890 | 2.66% |
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| PFM Health Sciences, LP | 192,406 | $46,544,935 | 2.19% |
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| Redmile Group, LLC | 155,076 | $37,514,435 | 1.78% |
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| F/M Investments LLC | 8,461 | $2,046,801 | 1.53% |
|---|
| NEXT CENTURY GROWTH INVESTORS LLC | 52,513 | $12,703,419 | 1.38% |
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| Atika Capital Management LLC | 37,500 | $9,071,625 | 1.19% |
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| Prosight Management, LP | 13,500 | $3,265,785 | 1.04% |
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| Bellevue Group AG | 237,252 | $57,393,631 | 0.92% |
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| Polar Asset Management Partners Inc. | 150,968 | $36,520,669 | 0.81% |
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| BRAIDWELL LP | 95,315 | $23,057,652 | 0.73% |
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| BRAUN STACEY ASSOCIATES INC | 58,840 | $14,234 | 0.69% |
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| Azimuth Capital Investment Management LLC | 54,113 | $13,090,476 | 0.64% |
|---|
| Champlain Investment Partners, LLC | 353,390 | $85,488,575 | 0.56% |
|---|
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 656,964 | $158,926,161 | 0.53% |
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| EAGLE ASSET MANAGEMENT INC | 353,450 | $85,503,089 | 0.51% |
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| Yorktown Management & Research Co Inc | 1,850 | $447,534 | 0.50% |
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| Laird Norton Wetherby Wealth Management, LLC | 27,096 | $6,554,794 | 0.37% |
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