| Soleus Capital Management, L.P. | 12,296,163 | $39,101,798 | 3.61% |
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| INTREPID FAMILY OFFICE LLC | 100,000 | $318,000 | 0.51% |
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| PURA VIDA INVESTMENTS, LLC | 301,697 | $959,396 | 0.18% |
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| GSA CAPITAL PARTNERS LLP | 614,568 | $1,954 | 0.17% |
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| INTREPID FAMILY OFFICE LLC | 25,000 | $79,500 | 0.13% |
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| Wealth Dimensions Group, Ltd. | 76,125 | $242,078 | 0.09% |
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| SENTINEL TRUST CO LBA | 149,037 | $474 | 0.07% |
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| State of Wyoming | 85,918 | $273,219 | 0.06% |
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| Capital Square, LLC | 16,520 | $38,822 | 0.05% |
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| Virtus Investment Advisers, Inc. | 21,500 | $68,370 | 0.05% |
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| ACADIAN ASSET MANAGEMENT LLC | 2,590,244 | $8,232 | 0.04% |
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| THOMPSON SIEGEL & WALMSLEY LLC | 457,400 | $1,455 | 0.02% |
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| STONERIDGE INVESTMENT PARTNERS LLC | 13,303 | $42 | 0.02% |
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| Moors & Cabot, Inc. | 66,350 | $210,993 | 0.01% |
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| Assenagon Asset Management S.A. | 971,674 | $3,089,923 | 0.01% |
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| AQR Capital Management | 1,542,760 | $4,905,977 | 0.01% |
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| Trivant Custom Portfolio Group, LLC | 3,750 | $11,925 | 0.01% |
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| TWO SIGMA ADVISERS, LP | 982,200 | $3,123,396 | 0.01% |
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| Estabrook Capital Management | 10,000 | $31,800 | 0.01% |
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| TWO SIGMA INVESTMENTS, LP | 534,551 | $1,699,872 | 0.01% |
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