| RA Capital Management | 3,002,087 | $544,308,000 | 8.21% |
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| DISCOVERY CAPITAL MANAGEMENT, LLC / CT | 323,517 | $58,657,000 | 7.86% |
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| Samsara BioCapital, LLC | 198,600 | $36,008,000 | 6.64% |
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| Foresite Capital Management I, LLC | 66,810 | $12,113,000 | 6.11% |
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| Foresite Capital Management II, LLC | 67,373 | $12,215,000 | 2.81% |
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| SECTORAL ASSET MANAGEMENT INC | 191,200 | $34,666,000 | 2.63% |
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| Rock Springs Capital Management LP | 461,000 | $83,584,000 | 1.82% |
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| TSP Capital Management Group, LLC | 23,525 | $4,265,000 | 1.50% |
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| Ikarian Capital, LLC | 195,700 | $35,483,000 | 1.19% |
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| SevenOneSeven Capital Management | 1,744 | $316,000 | 1.16% |
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| PFM Health Sciences, LP | 200,745 | $36,397,000 | 1.11% |
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| Carmignac Gestion | 529,169 | $95,938,000 | 1.10% |
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| Sargent Investment Group, LLC | 21,974 | $3,984,000 | 1.05% |
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| Cormorant Asset Management, LP | 250,000 | $45,328,000 | 1.01% |
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| Samsara BioCapital, LLC | 30,160 | $5,468,000 | 1.01% |
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| Vivo Capital, LLC | 157,487 | $28,554,000 | 1.00% |
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| Harvest Investment Services, LLC | 11,846 | $2,147,000 | 0.97% |
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| Sio Capital Management, LLC | 25,700 | $4,660,000 | 0.95% |
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| Strategic Wealth Management Group, LLC | 13,221 | $2,397,000 | 0.92% |
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| Faithward Advisors, LLC | 22,263 | $4,036,000 | 0.90% |
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