| Sarissa Capital Management LP | 16,390,000 | $157,835,700 | 21.26% |
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| AlphaCentric Advisors LLC | 292,500 | $2,816,775 | 1.60% |
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| Quantedge Capital Pte Ltd | 179,900 | $1,732,437 | 0.94% |
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| Intrinsic Value Partners, LLC | 50,355 | $484,919 | 0.62% |
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| Brown Capital Management | 3,719,796 | $35,821,635 | 0.55% |
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| ARMISTICE CAPITAL, LLC | 3,456,000 | $33,281,280 | 0.51% |
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| SummerHaven Investment Management, LLC | 67,765 | $652,577 | 0.48% |
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| BRAIDWELL LP | 1,348,099 | $12,982,193 | 0.41% |
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| AFFINITY INVESTMENT ADVISORS, LLC | 50,733 | $488,559 | 0.32% |
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| EMC Capital Management | 43,315 | $417 | 0.31% |
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| Redwood Investment Management, LLC | 329,807 | $3,176 | 0.28% |
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| Old West Investment Management, LLC | 56,160 | $540,820 | 0.27% |
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| New Vernon Capital Holdings II LLC | 31,705 | $305,319 | 0.26% |
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| Prairiewood Capital, LLC | 41,081 | $395,610 | 0.26% |
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| JUPITER ASSET MANAGEMENT LTD | 2,210,985 | $21,291,785 | 0.24% |
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| HUSSMAN STRATEGIC ADVISORS, INC. | 124,000 | $1,194,120 | 0.23% |
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| 13D Management LLC | 34,301 | $330,319 | 0.20% |
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| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,586,765 | $15,280,547 | 0.20% |
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| Parkman Healthcare Partners LLC | 100,000 | $963,000 | 0.18% |
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| MQS Management LLC | 29,066 | $279,906 | 0.17% |
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