| Discovery Value Fund | 561,561 | $17,756,559 | 9.73% |
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| MPM BioImpact LLC | 544,639 | $17,221,485 | 4.60% |
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| Casdin Capital, LLC | 1,178,075 | $37,250,732 | 4.12% |
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| HIMENSION CAPITAL (SINGAPORE) PTE. LTD. | 1,145,091 | $36,207,777 | 3.72% |
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| Atlas Venture Associates IX, LLC | 10,000 | $316,200 | 2.69% |
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| Deep Track Capital, LP | 2,000,000 | $63,240,000 | 2.44% |
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| ARK Investment Management | 9,948,629 | $314,575,638 | 2.41% |
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| Merlin Capital, Inc | 18,526 | $585,792 | 2.19% |
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| Orchard Capital Management, LLC | 159,155 | $5,032,481 | 1.86% |
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| TANG CAPITAL MANAGEMENT LLC | 397,600 | $12,572,112 | 1.77% |
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| Nikko Asset Management Americas, Inc. | 3,520,295 | $111,170,916 | 1.33% |
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| Elmwood Wealth Management, Inc. | 67,899 | $2,146,967 | 1.04% |
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| SECTORAL ASSET MANAGEMENT INC | 112,332 | $3,551,938 | 0.69% |
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| Capital Impact Advisors, LLC | 11,378 | $359,772 | 0.60% |
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| AtonRa Partners | 8,370 | $264,659 | 0.56% |
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| SILVERARC CAPITAL MANAGEMENT, LLC | 53,018 | $1,676,429 | 0.51% |
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| Intellectus Partners, LLC | 50,750 | $1,604,715 | 0.51% |
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| Avidity Partners Management LP | 379,100 | $11,987,142 | 0.48% |
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| REGENTS OF THE UNIVERSITY OF CALIFORNIA | 111,440 | $3,523,733 | 0.45% |
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| KRAEMATON INVESTMENT ADVISORS, INC | 11,530 | $364,579 | 0.45% |
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