| Redmile Group, LLC | 17,503,417 | $277,779,228 | 13.22% |
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| Fairmount Funds Management LLC | 5,929,592 | $94,102,625 | 11.32% |
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| CM Management, LLC | 500,000 | $7,935,000 | 8.42% |
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| SILVERARC CAPITAL MANAGEMENT, LLC | 1,307,435 | $20,748,993 | 6.29% |
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| Altium Capital Management LP | 725,000 | $11,505,750 | 6.00% |
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| RA Capital Management | 13,322,288 | $211,424,711 | 4.16% |
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| TANG CAPITAL MANAGEMENT LLC | 1,500,000 | $23,805,000 | 3.36% |
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| BRIDGER MANAGEMENT, LLC | 467,220 | $7,414,781 | 2.73% |
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| Birchview Capital, LP | 190,000 | $3,015,300 | 2.57% |
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| Boxer Capital, LLC | 2,961,000 | $46,991,070 | 2.50% |
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| Nicholas Investment Partners, LP | 2,067,561 | $32,812,193 | 2.45% |
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| Velan Capital Investment Management LP | 189,500 | $3,007,365 | 2.43% |
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| Decheng Capital Management III (Cayman), LLC | 415,880 | $6,600,016 | 2.20% |
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| Parkman Healthcare Partners LLC | 717,920 | $11,393,390 | 2.09% |
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| Sofinnova Investments, Inc. | 2,045,202 | $32,457,356 | 2.05% |
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| Tri Locum Partners LP | 369,912 | $5,870,503 | 1.88% |
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| IRONWOOD INVESTMENT MANAGEMENT LLC | 174,646 | $2,771,632 | 1.69% |
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| Hood River Capital Management LLC | 3,044,485 | $48,315,977 | 1.55% |
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| SECTORAL ASSET MANAGEMENT INC | 464,112 | $7,365,457 | 1.43% |
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| EMERALD MUTUAL FUND ADVISERS TRUST | 1,466,063 | $23,266,420 | 1.40% |
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