| Nan Fung Group Holdings Ltd | 129,647 | $45,299 | 21.48% |
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| Ensemble Capital Management | 247,326 | $86,416 | 7.50% |
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| Wellington Shields & Co., LLC | 59,362 | $20,741 | 6.82% |
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| Edgewood Management | 8,737,353 | $3,052,831 | 6.12% |
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| Geo Capital Gestora de Recursos Ltd | 32,923 | $13,285 | 5.95% |
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| Baillie Gifford | 20,907,058 | $7,304,926 | 5.12% |
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| BENDER ROBERT & ASSOCIATES | 49,937 | $17,448 | 4.97% |
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| Iron Triangle Partners LP | 110,000 | $38,434 | 4.57% |
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| RTW INVESTMENTS, LP | 509,375 | $177,976 | 3.68% |
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| DF DENT & CO INC | 789,972 | $276,016 | 3.18% |
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| TITLEIST ASSET MANAGEMENT, LTD. | 44,103 | $15,410 | 3.06% |
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| ROSENBLUM SILVERMAN SUTTON S F INC /CA | 32,592 | $11,388 | 2.92% |
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| Soleus Capital Management, L.P. | 62,300 | $21,768 | 2.81% |
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| Tekla Capital Management LLC | 226,212 | $79,038 | 2.78% |
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| MARTIN CURRIE LTD | 468,934 | $163,846 | 2.63% |
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| AMERICAN CAPITAL MANAGEMENT INC | 244,167 | $85,312 | 2.52% |
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| INTERNATIONAL BIOTECHNOLOGY TRUST PLC | 48,000 | $10,762 | 2.43% |
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| Biondo Investment Advisors, LLC | 39,176 | $13,688 | 2.41% |
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| Sustainable Growth Advisers, LP | 1,176,193 | $410,962 | 2.28% |
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| RiverPark Advisors, LLC | 32,751 | $11,443 | 2.10% |
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