| Valor Management LLC | 11,218,033 | $367,614,941 | 98.94% |
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| Nan Fung Group Holdings Ltd | 368,665 | $12,081,152 | 9.78% |
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| venBio Partners LLC | 1,035,396 | $33,929,927 | 9.62% |
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| Vivo Capital, LLC | 2,606,247 | $85,406,714 | 9.36% |
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| INTERNATIONAL BIOTECHNOLOGY TRUST PLC | 314,500 | $10,306,165 | 3.47% |
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| AlphaCentric Advisors LLC | 122,000 | $3,997,940 | 2.27% |
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| ASHFORD CAPITAL MANAGEMENT INC | 434,148 | $14,227,030 | 2.09% |
|---|
| Altium Capital Management LP | 117,000 | $3,834,090 | 2.00% |
|---|
| NEUMEIER POMA INVESTMENT COUNSEL LLC | 595,490 | $19,514,207 | 1.90% |
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| TANG CAPITAL MANAGEMENT LLC | 271,200 | $8,887,224 | 1.25% |
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| Perceptive Advisors | 996,306 | $32,648,948 | 1.09% |
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| 683 Capital Management, LLC | 350,000 | $11,469,500 | 0.89% |
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| Paradiem, LLC | 77,184 | $2,529,320 | 0.76% |
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| Yelin Lapidot Holdings Management Ltd. | 37,905 | $1,242,147 | 0.74% |
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| Hood River Capital Management LLC | 318,544 | $10,438,687 | 0.34% |
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| Rhenman & Partners Asset Management AB | 81,474 | $2,669,903 | 0.29% |
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| Watershed Asset Management, L.L.C. | 6,929 | $227,063 | 0.27% |
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| PDT Partners, LLC | 55,937 | $1,833,055 | 0.23% |
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| RICE HALL JAMES & ASSOCIATES, LLC | 101,094 | $3,312,850 | 0.21% |
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| HUSSMAN STRATEGIC ADVISORS, INC. | 31,000 | $1,015,870 | 0.19% |
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