| Vivo Capital, LLC | 10,881,144 | $31,337,695 | 3.43% |
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| Sio Capital Management, LLC | 2,081,216 | $5,993,902 | 1.86% |
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| Pivotal bioVenture Partners Investment Advisor LLC | 1,375,000 | $3,960,000 | 1.58% |
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| TCG Crossover Management, LLC | 3,038,889 | $8,752,000 | 1.29% |
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| Logos Global Management LP | 2,525,000 | $7,272,000 | 0.97% |
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| SPHERA FUNDS MANAGEMENT LTD. | 1,531,497 | $4,410,711 | 0.80% |
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| Orbimed Advisors | 9,308,726 | $26,809,131 | 0.57% |
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| GREAT POINT PARTNERS LLC | 579,667 | $1,669,441 | 0.30% |
|---|
| Temasek Holdings (Private) Ltd | 9,901,940 | $28,517,587 | 0.17% |
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| TANG CAPITAL MANAGEMENT LLC | 159,087 | $458,171 | 0.06% |
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| DeepCurrents Investment Group LLC | 275,000 | $792,000 | 0.03% |
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| Schonfeld Strategic Advisors LLC | 759,393 | $2,187,051 | 0.02% |
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| Baker Brothers Advisors | 1,000,000 | $2,880,000 | 0.02% |
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| LMR Partners LLP | 484,516 | $873,505 | 0.01% |
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| Hudson Bay Capital Management LP | 4,000,000 | $2,257,920 | 0.01% |
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| ADAGE CAPITAL PARTNERS GP, L.L.C. | 850,000 | $2,448,000 | 0.01% |
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| Verition Fund Management LLC | 86,644 | $249,535 | 0.00% |
|---|
| PRELUDE CAPITAL MANAGEMENT, LLC | 16,327 | $47,022 | 0.00% |
|---|
| Tower Research Capital LLC (TRC) | 34,434 | $99,170 | 0.00% |
|---|
| Bellevue Group AG | 38,000 | $109,440 | 0.00% |
|---|