| TANG CAPITAL MANAGEMENT LLC | 6,450,000 | $8,320,500 | 1.17% |
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| BVF INC/IL | 6,595,801 | $8,508,583 | 0.23% |
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| Bronte Capital Management Pty Ltd. | 925,245 | $1,193,566 | 0.12% |
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| Formidable Asset Management, LLC | 318,111 | $410,363 | 0.09% |
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| Congress Park Capital LLC | 112,450 | $145,061 | 0.08% |
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| Forefront Analytics, LLC | 49,421 | $63,754 | 0.04% |
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| Ground Swell Capital, LLC | 10,966 | $14,146 | 0.02% |
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| Clearline Capital LP | 196,583 | $253,592 | 0.02% |
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| CORNERCAP INVESTMENT COUNSEL INC | 81,352 | $104,944 | 0.02% |
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| ACADIAN ASSET MANAGEMENT LLC | 2,646,190 | $3,412 | 0.01% |
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| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 372,124 | $480,040 | 0.01% |
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| Tidal Investments LLC | 318,111 | $410,363 | 0.01% |
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| Laurion Capital Management LP | 1,188,225 | $1,532,810 | 0.01% |
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| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,052,105 | $1,357,215 | 0.01% |
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| UBS OCONNOR LLC | 259,965 | $335,355 | 0.01% |
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| Byrne Asset Management LLC | 8,000 | $10,000 | 0.01% |
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| AlphaMark Advisors, LLC | 10,548 | $14 | 0.01% |
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| WestHill Financial Advisors, Inc. | 17,082 | $22,036 | 0.01% |
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| Assenagon Asset Management S.A. | 425,921 | $549,438 | 0.00% |
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| Renaissance Technologies | 930,100 | $1,200 | 0.00% |
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