| TANAKA CAPITAL MANAGEMENT INC | 159,791 | $1,868 | 5.34% |
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| Opaleye Management Inc. | 1,205,000 | $14,086,450 | 4.58% |
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| GABLES CAPITAL MANAGEMENT INC. | 431,955 | $5,049,554 | 3.51% |
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| JW Asset Management, LLC | 563,392 | $6,586,052 | 2.85% |
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| DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) | 8,192,000 | $95,764,480 | 2.11% |
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| Seaport Global Advisors, LLC | 45,941 | $537,050 | 1.61% |
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| Capital Impact Advisors, LLC | 67,067 | $784,013 | 1.31% |
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| Ikarian Capital, LLC | 505,862 | $5,913,527 | 0.71% |
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| MOODY ALDRICH PARTNERS LLC | 273,512 | $3,197,355 | 0.61% |
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| Paradiem, LLC | 166,905 | $1,951,119 | 0.59% |
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| Yorktown Management & Research Co Inc | 40,500 | $473,445 | 0.53% |
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| CLARK ESTATES INC/NY | 188,000 | $2,197,720 | 0.40% |
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| AFFINITY INVESTMENT ADVISORS, LLC | 48,740 | $569,771 | 0.37% |
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| OBERWEIS ASSET MANAGEMENT INC/ | 293,600 | $3,432,184 | 0.36% |
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| Westover Capital Advisors, LLC | 85,518 | $999,705 | 0.36% |
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| HUSSMAN STRATEGIC ADVISORS, INC. | 157,500 | $1,841,175 | 0.35% |
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| Jackson Creek Investment Advisors LLC | 68,210 | $797 | 0.34% |
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| GLOBEFLEX CAPITAL L P | 234,284 | $2,738,780 | 0.32% |
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| NAVELLIER & ASSOCIATES INC | 136,614 | $1,597,018 | 0.27% |
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| EMC Capital Management | 28,483 | $333 | 0.24% |
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